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Journal articles on the topic '159.942 (043.2)'

Author: Grafiati

Published: 30 May 2022

Last updated: 31 July 2025

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1

BHANUSHALI, APARNA A., AASHISH CONTRACTOR, and BIBHU R. DAS. "Variant at 9p21 rs1333049 is associated with age of onset of coronary artery disease in a Western Indian population: a case control association study." Genetics Research 95, no. 5 (2013): 138–45. http://dx.doi.org/10.1017/s0016672313000189.

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SummaryThe 9p21 chromosomal region has been associated with coronary artery disease (CAD) in many genome wide association studies (GWAS). To date no information exists regarding the rs1333039 SNP which showed the strongest association in the WTCCC GWAS with CAD risk in the Indian population. The present study attempts to replicate the findings in the Indian population.Genotyping for rs1333049 was done in 229 cases and 151 controls by allele-specific real-time assay.A higher frequency of the risk allele rs1333049C was seen in cases (0·60) as compared with controls (0·49), which associated with

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Elliot, A. J., M. P. Chenier, and D. C. Ouellette. "Radiolysis studies on the corrosion inhibitors 1 -hexyn-3-ol, cinnamonitrile, and 1,3-diethyl-2-thiourea." Canadian Journal of Chemistry 73, no. 12 (1995): 2137–42. http://dx.doi.org/10.1139/v95-264.

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In this publication we report: (i) the rate constants for reaction of the hydrated electron with 1-hexyn-3-ol ((8.6 ± 0.3) × 108 dm3 mol−1 s−1 at 18 °C), cinnamonitrile ((2.3 ± 0.2) × 1010 dm3 mol−1 s−1 at 20 °C), and 1,3-diethyl-2-thiourea ((3.5 ± 0.3) × 108 dm3 mol−1 s−1 at 22 °C). For cinnamonitrile and diethylthiourea, the temperature dependence up to 200 °C and 150 °C, respectively, is also reported; (ii) the rate constants for the reaction of the hydroxyl radical with 1-hexyn-3-ol ((5.5 ± 0.5) × 109 dm3 mol−1 s−1 at 20 °C), cinnamonitrile ((9.2 ± 0.3) × 109 dm3 mol−1 s−1 at 21 °C), and d

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Harrowfield, Jack M., Raj Pal Sharma, Brian W. Skelton, and Allan H. White. "Structural Systematics of 2/4-Nitrophenoxide Complexes of Closed-Shell Metal Ions. III 2/4-Nitrophenoxides of Univalent Heavy Metals." Australian Journal of Chemistry 51, no. 8 (1998): 735. http://dx.doi.org/10.1071/c97100.

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Room-temperature single-crystal X-ray studies are recorded for 2- and 4-nitrophenoxide salts of silver(I) and thallium(I), M(2-np) and Tl(4-np) (anhydrous), and Ag(4-np).H2O. Ag(2-np) is monoclinic, P21/c, a 9·012(4), b 5·743(5), c 12·594(5) Å, β 104·34(4)°, Z = 4; conventional R on |F| was 0·042 for No 1378 independent ‘observed’ (I > 3σ(I)) reflections. Tl(2-np) is monoclinic, C2/c, a 27·250(3), b 3·712(1), c 15·147(3) Å, β 114·41(1)°, Z = 8, R 0·025 for No 1346. Ag(4-np).H2O is monoclinic, P21/a, a 5·613(6), b 13·191(7), c 9·844(5) Å, β 92·50(6)°, Z = 4, R 0 ·033 for No 622. Tl(4-np) is

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Semenova, Lioubov I., and Allan H. White. "Structural Systematics of Rare Earth Complexes. XIX (Hydrated) 1 : 2 Mononuclear Adducts of Lanthanoid(III) Chlorides with 2,2′-Bipyridine and 1,10-Phenanthroline." Australian Journal of Chemistry 52, no. 6 (1999): 571. http://dx.doi.org/10.1071/ch98052.

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Room-temperature single-crystal X-ray structure determinations are recorded for a number of adducts of hydrated lanthanoid(III) trichlorides with 2,2′-bipyridine (‘bpy’) and 1,10-phenanthroline (‘phen’), crystallized from water, methanol or ethanol solutions, containing mononuclear arrays with 1 : 2 Ln/bpy or phen stoichiometry. LaCl3/phen/H2O(1 : 3 : 9), [(phen)2La(OH2)5]Cl3.phen.4H2O, although of overall 1 : 3 LaCl3/phen stoichiometry, has a lattice phen; it is orthorhombic, Pnna, a 19·947(7), b 16·457(5), c 12·213(2) Å, Z = 4; conventional R on |F| was 0·030 for No 2567 ‘observed’ (I >3σ

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ใจชื้น, พิไลวรรณ. "ปัจจัยที่มีความสัมพันธ์กับพฤติกรรมเสี่ยงจากการใช้สื่อสังคมออนไลน์ของวัยรุ่นในชุมชนแห่งหนึ่งในเขตกรุงเทพมหานคร". Journal of Thailand Nursing and Midwifery Council 39, № 01 (2024): 1–15. http://dx.doi.org/10.60099/jtnmc.v39i01.266375.

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บทนำ การใช้สื่อสังคมออนไลน์มีประโยชน์ในการสืบค้นความรู้และทักษะหรือการสื่อสาร อย่างไรก็ตาม การขาดทักษะที่ดีในการใช้สื่ออาจมีความเสี่ยงจากการใช้สื่อสังคมออนไลน์ โดยเฉพาะวัยรุ่นซึ่งเป็นกลุ่มที่ใช้สื่อสังคมออนไลน์ค่อนข้างมาก วัตถุประสงค์การวิจัย 1) เพื่อศึกษาปัจจัยส่วนบุคคล ทักษะการรู้เท่าทันสื่อ และพฤติกรรมเสี่ยงจากการใช้สื่อสังคมออนไลน์ของวัยรุ่น และ 2) เพื่อศึกษาความสัมพันธ์ระหว่างปัจจัยส่วนบุคคล (เพศ อายุ ระดับ การศึกษา) และทักษะการรู้เท่าทันสื่อ กับพฤติกรรมเสี่ยงจากการใช้สื่อสังคมออนไลน์ของวัยรุ่นในชุมชนแห่งหนึ่งของกรุงเทพมหานคร การออกแบบการวิจัย การวิจัยเชิงพรรณนาหาความสัมพันธ์ วิธีดำเนินกา

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Lertwannawit, Aurathai, and Nak Gulid. "A Structural Relationship Between Domestic Tourist Satisfaction, Trust, Switching Barriers And Retention." International Business & Economics Research Journal (IBER) 13, no. 6 (2014): 1375. http://dx.doi.org/10.19030/iber.v13i6.8927.

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The objective of this study is to examine the direct effects of satisfaction, trust, and switching barriers on customer retention in Bangkok and Pattaya, Chonburi province. Four hundred and forty questionnaires were distributed as the means of data collection and analyzed using structural equation modeling (SEM). The results of testing hypotheses are as follows: The developed structural equation model of customer retention in Bangkok was congruent with empirical data as the criterion, as follows: (?2 = 141.098, df = 69, ?2/df = 2.045, GFI = .956, AGFI = .933, RMSEA = .049, RMR = .073, CFI = .9

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Lozano, Miguel, Ana Galan, Roberto Mazzara, Laurence Corash, and Gines Escolar. "Leucocyte-Reduced Buffy Coat Platelet Concentrates (BCPC) Treated with INTERCEPT™ Stored up to 7 Days: Hemostatic Function in a Whole Blood Flow System." Blood 106, no. 11 (2005): 956. http://dx.doi.org/10.1182/blood.v106.11.956.956.

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Abstract Background: The risk of bacterial growth has limited the shelf life of platelet concentrates (PC) to 5 days. Modern platelet storage containers facilitate storage for up to 7 days, if bacterial contamination is prevented. INTERCEPT (Baxter, La Chatre, France; Cerus, Concord, CA) photochemical treatment (PCT) for pathogen reduction based on amotosalen (150μM) and UVA illumination (3 J/cm2) inactivates high titers of bacteria in PC (Transfusion2004; 44: 1496–1504). Adhesion and aggregation of platelets to injured vascular surfaces are critical aspects of platelet hemostatic function. In

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Kaye, S. B., J. Paul, J. Cassidy, et al. "Mature results of a randomized trial of two doses of cisplatin for the treatment of ovarian cancer. Scottish Gynecology Cancer Trials Group." Journal of Clinical Oncology 14, no. 7 (1996): 2113–19. http://dx.doi.org/10.1200/jco.1996.14.7.2113.

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PURPOSE In 1992, we reported the first results of a randomized study in ovarian cancer, comprising two doses of cisplatin and indicated a significant difference (P = .0008) in median survival. Four years later, we now describe the results of this trial. PATIENTS AND METHODS After a median follow-up of 4 years and 9 months, 115 of 159 cases of advanced ovarian cancer, originally randomized to receive six cycles of cyclophosphamide 750 mg/m2 and either a high dose (HD) of 100 mg/m2 cisplatin or a low dose (LD) of 50 mg/m2 (LD) cisplatin, have now died. RESULTS The overall survival for HD and LD

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Marincowitz, Carl, Omar Bouamra, Tim Coates, et al. "1427 The effect of the COVID-19 pandemic on major trauma presentations and patient outcomes in English hospitals." Emergency Medicine Journal 39, no. 12 (2022): A960.2—A964. http://dx.doi.org/10.1136/emermed-2022-rcem2.2.

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Aims, Objectives and BackgroundThere is evidence that COVID-19 ‘lockdowns’ may have contributed to increased non-accidental injury, domestic violence and self-harm related to deteriorating mental health. Internationally, there is also evidence that the diversion of health care resources may led to worse outcomes for patients presenting with major trauma. There has been no previous national evaluation of ‘lockdown’ measures impact on the characteristics, treatment pathways and outcomes of trauma patients in EnglandWe aimed to assess the impact of successive lockdowns on the volume, demographics

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Perumal, Karthikeyan, and Mahadev Potharaju. "Nature of intrafractional and interfractional prostate motion during stereotactic radiation." Journal of Clinical Oncology 34, no. 2_suppl (2016): 152. http://dx.doi.org/10.1200/jco.2016.34.2_suppl.152.

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152 Background: To characterize the intra-fraction and inter-fraction prostate motion as tracked by the X-ray images of the implanted gold fiducials during stereotactic radiotherapy with CyberKnife. The published data have analysed the linear and angular prostate motion intrafraction and interfraction prostate motion among patients. We sought to quantify the same within each patient. Methods: Twenty Five patients with localized prostate cancer treated with CyberKnife radiosurgery between January 2013 and August 2015 were studied retrospectively. A data set constitutes the deviations derived fr

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Fairushina, I., D. Abdulganieva, E. Kirillova, and E. Mukhametshina. "AB1091 FREQUENCY OF ULTRASOUND ENTHESITIS AND SYNOVITIS IN DIFFERENT ANATOMICAL SITES OF UPPER AND LOWER EXTREMITIES IN PATIENTS WITH PSORIATIC ARTHRITIS: CROSS-SECTIONAL STUDY." Annals of the Rheumatic Diseases 79, Suppl 1 (2020): 1834.2–1835. http://dx.doi.org/10.1136/annrheumdis-2020-eular.5900.

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Background:Psoriatic arthritis (PsA) is characterized by asymptomatic enthesitis and synovitis1. The location of pathological lesions is not clear. Furthermore, ultrasound (US) enthesitis indices assess limited number of entheses.Objectives:To detect the most frequent sites of US enthesitis and synovitis in PsA.Methods:57 PsA patients were enrolled to the study. US examination included bilateral large 14 joints; entheses of tendons and ligaments in the projection of examined joints (total number - 54). Totally, 798 joints, 3078 entheses were examined. The study was conducted by US rheumatologi

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Penson, Richard T., Ricardo Villalobos Valencia, David Cibula, et al. "Olaparib Versus Nonplatinum Chemotherapy in Patients With Platinum-Sensitive Relapsed Ovarian Cancer and a Germline BRCA1/2 Mutation (SOLO3): A Randomized Phase III Trial." Journal of Clinical Oncology 38, no. 11 (2020): 1164–74. http://dx.doi.org/10.1200/jco.19.02745.

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PURPOSE A phase II study (ClinicalTrials.gov identifier: NCT00628251 ) showed activity of olaparib capsules versus pegylated liposomal doxorubicin in patients with germline BRCA-mutated platinum-resistant or partially platinum-sensitive relapsed ovarian cancer. We conducted a phase III trial (SOLO3) of olaparib tablets versus nonplatinum chemotherapy in patients with germline BRCA-mutated platinum-sensitive relapsed ovarian cancer who had received at least 2 prior lines of platinum-based chemotherapy. PATIENTS AND METHODS In this randomized, open-label trial, patients were randomly assigned 2:

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DiGiorgio, Anthony M., Praveen V. Mummaneni, Jonathan L. Fisher, et al. "Change in Policy Allowing Overlapping Surgery Decreases Length of Stay in an Academic, Safety-Net Hospital." Operative Neurosurgery 17, no. 6 (2019): 543–48. http://dx.doi.org/10.1093/ons/opz009.

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Abstract BACKGROUND The practice of surgeons running overlapping operating rooms has recently come under scrutiny. OBJECTIVE To examine the impact of hospital policy allowing overlapping rooms in the case of patients admitted to a tertiary care, safety-net hospital for urgent neurosurgical procedures. METHODS The neurosurgery service at the hospital being studied transitioned from routinely allowing 1 room per day (period 1) to overlapping rooms (period 2), with the second room being staffed by the same attending surgeon. Patients undergoing neurosurgical intervention in each period were retro

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Okusa, M. D., K. R. Lynch, D. L. Rosin, L. Huang, and Y. Y. Wei. "Apical membrane and intracellular distribution of endogenous alpha 2A-adrenergic receptors in MDCK cells." American Journal of Physiology-Renal Physiology 267, no. 3 (1994): F347—F353. http://dx.doi.org/10.1152/ajprenal.1994.267.3.f347.

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The purpose of the current studies was to characterize the endogenous alpha 2-adrenergic receptor (AR) subtypes present in Madin-Darby canine kidney (MDCK) cells and to determine their level of expression and pattern of distribution. By saturation binding analysis with [3H]MK-912, MDCK cells expressed high levels of alpha 2-ARs with a maximum receptor density (Bmax) of 798 +/- 55 fmol/mg protein and an equilibrium dissociation constant (Kd) of 0.98 +/- 0.32 nM. Competitive binding studies using prazosin, oxymetazoline, phentolamine, and epinephrine to displace [3H]MK-912 demonstrated inhibitio

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Firsov, Alexander A., Sergey N. Vostrov, Olga V. Kononenko, Stephen H. Zinner, and Yury A. Portnoy. "Prediction of the Effects of Inoculum Size on the Antimicrobial Action of Trovafloxacin and Ciprofloxacin againstStaphylococcus aureus and Escherichia coli in an In Vitro Dynamic Model." Antimicrobial Agents and Chemotherapy 43, no. 3 (1999): 498–502. http://dx.doi.org/10.1128/aac.43.3.498.

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ABSTRACT The effect of inoculum size (N 0) on antimicrobial action has not been extensively studied in in vitro dynamic models. To investigate this effect and its predictability, killing and regrowth kinetics of Staphylococcus aureus andEscherichia coli exposed to monoexponentially decreasing concentrations of trovafloxacin (as a single dose) and ciprofloxacin (two doses at a 12-h interval) were compared atN 0 = 106 and 109 CFU/ml (S. aureus) and at N 0 = 106, 107, and 109 CFU/ml (E. coli). A series of pharmacokinetic profiles of trovafloxacin and ciprofloxacin with respective half-lives of 9.

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Hussain, Syed Iqrar, Ammad Hassan Khan, Zia ur Rehman, et al. "Effect of Weak Zones on Resilience of Sustainable Surface Course Mixtures of Fresh-Reclaimed Asphalt Pavement." Sustainability 14, no. 16 (2022): 9966. http://dx.doi.org/10.3390/su14169966.

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The use of reclaimed asphalt pavement (RAP) is necessary for sustainable and cost-effective road infrastructure construction. This research investigates the effect of the area of weak zones (WZ) on the resilient modulus (MRT) of mixtures of fresh asphalt with 20% RAP. Experimentation on fresh asphalt–RAP mixtures comprising Superpave (SP-A, SP-B) and Asphalt Institute (MS-2) gradations with 20/30, 40/50, 60/70 and 80/100 penetration grade binders was carried out. WZ were determined based on the analysis of magnified digital images of asphalt specimens obtained using optical microscopy. This st

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Iroh Tam, Pui-Ying, Hussein H. Twabi, Mtisunge Gondwe, Thomasena O'Byrne, Norman Lufesi, and Nicola Desmond. "Child acute illness presentation and referrals at primary health clinics in Malawi: a secondary analysis of ASPIRE." BMJ Open 14, no. 4 (2024): e079589. http://dx.doi.org/10.1136/bmjopen-2023-079589.

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ObjectivesWe aimed to assess the prevalence, presentation and referral patterns of children with acute illness attending primary health centres (PHCs) in a low-resource setting.Design, setting and participantsWe conducted a secondary analysis of ASPIRE. Children presenting at eight PHCs in urban Blantyre district in southern Malawi with both recorded clinician and mHealth (non-clinician) triage data were included, and patient records from different data collection points along the patient healthcare seeking pathway were consolidated and analysed.ResultsBetween April 2017 and September 2018, a

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Moghanaki, Drew, Renjian Jiang, David Gutman, et al. "Utilization patterns of immune checkpoint inhibitors (ICI) for non-small cell lung cancer (NSCLC) within the veterans health administration (VHA)." Journal of Clinical Oncology 38, no. 15_suppl (2020): e21630-e21630. http://dx.doi.org/10.1200/jco.2020.38.15_suppl.e21630.

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e21630 Background: ICI are used routinely for treatment of lung cancer. We investigated the utilization of PD-1/PD-L1 inhibitors for NSCLC in the VHA. Methods: The VHA Corporate Data Warehouse was queried for data on ICI utilization in NSCLC [IRB #00113521]. The first date of any ICI dispensed was January 6, 2015 and therefore this investigation evaluated all patients diagnosed with NSCLC between 2015 –2019. Results: A total of 27,586 Veterans were diagnosed with NSCLC during the study period with demographics: 76.3% Caucasian, 16.3% black; 97.0% male; median age 71 years. Stage distribution w

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Baraliakos, X., E. Pournara, D. D. Gladman, P. J. Mease, S. Jahandideh, and L. Coates. "POS1110 PATIENT CLUSTERS IDENTIFIED BY MACHINE LEARNING: DATA FROM A POOLED ANALYSIS OF PHASE-3 TRIALS OF SECUKINUMAB IN PSORIATIC ARTHRITIS, ANKYLOSING SPONDYLITIS AND PSORIATIC ARTHRITIS WITH AXIAL MANIFESTATIONS." Annals of the Rheumatic Diseases 82, Suppl 1 (2023): 879.1–879. http://dx.doi.org/10.1136/annrheumdis-2023-eular.2975.

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BackgroundUniversally acceptable criteria to define axial psoriatic arthritis (PsA) are lacking. Machine learning (ML) algorithms can detect patterns from large clinical datasets and identify clusters with potential therapeutic or prognostic significance in PsA patients (pts) with axial manifestations.[1]ObjectivesTo identify pt clusters based on baseline (BL) demographics and clinical indicators to support characterisation of the axial PsA phenotype within the spondyloarthritis (SpA) spectrum.MethodsPooled BL demographics and clinical data of secukinumab (SEC)-treated pts from 10 Phase-3 stud

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Carcao, Manuel, Mariana Silva, Michele David, et al. "IVMP+IVIG raises platelet counts faster than IVIG alone: results of a randomized, blinded trial in childhood ITP." Blood Advances 4, no. 7 (2020): 1492–500. http://dx.doi.org/10.1182/bloodadvances.2019001343.

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Abstract Children with immune thrombocytopenia (ITP) rarely suffer from life-threatening bleeds (eg, intracranial hemorrhage). In such settings, the combination of IV methylprednisolone (IVMP) with IV immune globulin (IVIG) is used to rapidly increase platelet counts (PCs). However, there are no controlled data to support using combination therapy over IVIG alone. We conducted a randomized, double-blind, placebo-controlled study to evaluate the rapidity of the PC increment and associated adverse events (AEs) between 2 regimens: A (IV placebo) and B (IVMP 30 mg/kg), both given over 1 hour, foll

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Linehan, C. J., D. P. Armstrong, P. T. Doyle, and F. Johnson. "A survey of water use efficiency on irrigated dairy farms in northern Victoria." Australian Journal of Experimental Agriculture 44, no. 2 (2004): 131. http://dx.doi.org/10.1071/ea02234.

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Water use efficiency (WUE) in irrigated dairy systems has been defined, in this paper, as the amount of milk (kg milk fat plus protein) produced from pasture per megalitre of water (irrigation plus effective rainfall). A�farm survey was conducted for the 1997–98 and 1998–99 seasons in the Goulburn Irrigation System (GIS) and Murray Irrigation System (MIS) when the irrigation water allocated to irrigators in the GIS was low (100–120% of water right compared with the MIS which was 130 and 200% of water right). These data were analysed in conjunction with information collected on the same farms i

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Patel, Priti, Mayra Telesca, and De-Hui Ku. "The Comparison of Fibrin Monomer (FM) Performance to Other Activation Markers (TAT, PF1.2 and DD)." Blood 118, no. 21 (2011): 5259. http://dx.doi.org/10.1182/blood.v118.21.5259.5259.

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Abstract Abstract 5259 In this study, we attempted to determine the performance of the soluble fibrin monomer complex (SFMC) test in comparison to known activation markers, such as prothrombin fragment 1.2 (PF1.2), thrombin antithrombin complex (TAT) and d-dimer (DD). We have used the STA(R)-Liatest FM and STA(R)-Liatest D-Di kits to measure the SFMC and d-dimer levels. A total of 25 patients were included in this study. The data and demographic information are shown in the table below. ID GENDER AGE FM TAT PF1.2 D-dimer 1 M 66 0.42 2.3 1988 0.05 2 F 31 27.93 >60.0 >12000 2.39 3 F 24 3.4

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Bianchi, Paola, Elisa Fermo, Fulvio Mozzi, Maurizio Marconi, and Alberto Zanella. "Presence of JAK2 V617F Mutation in Peripheral Blood of Blood Donors with Upper-Limit Hematocrit and Platelet Values." Blood 110, no. 11 (2007): 2533. http://dx.doi.org/10.1182/blood.v110.11.2533.2533.

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Abstract The somatic mutation V617F of JAK2 gene has been identified as a pathogenic factor in typical chronic myeloproliferative diseases (MPDs), in particular polycythemia vera, essential thrombocythemia, and myelofibrosis with myeloid metaplasia. Recently, two studies showed the presence of this mutation also in 37/3935 subjects with non haematological diseases (Xu et al, 2006) and 5/52 healthy donors (Sidon et al, 2006), suggesting that V617F mutation may occur in the absence of MPD phenotype and that probably is not sufficient per se to induce MPDs. The aim of this study was to search for

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Park, John K., Tiffany Hodges, Leopold Arko, et al. "Scale to Predict Survival After Surgery for Recurrent Glioblastoma Multiforme." Journal of Clinical Oncology 28, no. 24 (2010): 3838–43. http://dx.doi.org/10.1200/jco.2010.30.0582.

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Purpose Despite initial treatment with surgical resection, radiotherapy, and chemotherapy, glioblastoma multiforme (GBM) virtually always recurs. Surgery is sometimes recommended to treat recurrence. In this study, we sought to devise a preoperative scale that predicts survival after surgery for recurrent glioblastoma multiforme. Patients and Methods The preoperative clinical and radiographic data of 34 patients who underwent re-operation of recurrent GBM tumors were analyzed using Kaplan-Meier survival analysis and Cox proportional hazards regression modeling. The factors associated with decr

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Albero, G., V. Longobardi, G. Zullo, et al. "144 INFLUENCE OF REPEATED OVUM PICKUP ON BUFFALO WELFARE." Reproduction, Fertility and Development 26, no. 1 (2014): 185. http://dx.doi.org/10.1071/rdv26n1ab144.

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The aim of this work was to evaluate the effect of repeated ovum pickup (OPU) on buffalo welfare. The OPU was carried out as previously described (Neglia et al. 2003 Theriogenology 59, 1123–1130) twice per week on 11 buffalo cows at 121 ± 15 days in milk for 2 months (end of October–end of December). Blood samples were collected before the beginning of the trial (time 0), after 1 month (time 1), and after 2 months (time 2) in animals that had undergone OPU and in control animals (n = 10) of the same herd. The following parameters of clinical immunology were evaluated on sera: haemolytic comple

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Durig, James R., Chunhua Pan, Witold Witkowski, and Gamil A. Guirgis. "Conformational stability, infrared and Raman spectra, and vibrational assignment of ethyl bromogermane." Canadian Journal of Chemistry 82, no. 6 (2004): 964–77. http://dx.doi.org/10.1139/v04-048.

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The infrared spectra (320030 cm1) of ethyl bromogermane, CH3CH2GeH2Br, in the gaseous phase and of amorphous and annealed solid samples as well as the Raman spectrum (3200100 cm1) of the liquid have been recorded. Variable-temperature (105 to 150 °C) studies of the infrared spectra of a sample dissolved in liquid krypton have been carried out. From these data, the enthalpy difference between the gauche and trans conformers has been determined to be 158 ± 16 cm1 (1.89 ± 0.20 kJ/mol), with the gauche conformer being the more stable form. This result is consistent with the prediction from

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Manoonkitiwongsa, Panya S., Cathy Jackson-Friedman, Paul J. McMillan, Robert L. Schultz, and Patrick D. Lyden. "INTRA-ARTERIAL INFUSION OF VASCULAR ENDOTHELIAL GROWTH FACTOR IN NORMAL AND ISCHEMIC BRAINS HAS NO EFFECT ON ANGIOGENESIS." Stroke 32, suppl_1 (2001): 356. http://dx.doi.org/10.1161/str.32.suppl_1.356-b.

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P95 INTRODUCTION: Stimulation of angiogenesis in ischemic brains may be of major value in stroke therapy. Administration of vascular endothelial growth factor (VEGF) is considered particularly effective as an angiogenic factor for hypoxia-related injuries. We therefore quantitatively compared the effect of VEGF on microvessels of normal and ischemic brain cortices. Vascular parameters of microvessels measured included changes in numerical (N A ), volume (V v ), surface (S v ) and length (L v ) densities along with diameter. METHODS: VEGF 165 protein at 1μg/ml was infused into the common caroti

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Hcini, Najeh, Véronique Lambert, Olivier Picone, et al. "Causes and consequences of fever in Amazonian pregnant women: A large retrospective study from French Guiana." PLOS Neglected Tropical Diseases 17, no. 10 (2023): e0011721. http://dx.doi.org/10.1371/journal.pntd.0011721.

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Objective The aim of this study was to describe different causes and consequences of fever during pregnancy in Western French Guiana and along the Maroni River. Study design A retrospective single-center study including all patients with a history of documented fever ≥ 38°C during pregnancy at the West French Guiana Hospital for 9 years. Postpartum fever and nosocomial infections were excluded. We focused on medical history and on clinical and biological findings. Causes were characterized as confirmed or uncertain and then classified as preventable or non-preventable. Results A total of 940 p

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Horenkamp-Sonntag, Dirk, Roland Linder, Susanne Engel, Udo Schneider, and Frank Verheyen. "Potential von Arbeitsunfähigkeits-Daten zur tagesgenauen Bestimmung des Krankheitsbeginns in GKV-Routinedaten." Gesundheitsökonomie & Qualitätsmanagement 23, no. 02 (2017): 88–96. http://dx.doi.org/10.1055/s-0043-110765.

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Zusammenfassung Zielsetzung In der Versorgungsforschung ist der exakte Zeitpunkt des Krankheitsbeginns relevant, z. B. zur Messung der Leitlinienadhärenz. Bei akutem nicht-spezifischen Rückenschmerz sollte in den ersten sechs Wochen keine Bildgebung erfolgen. Da ambulant nur auf Quartalsebene dokumentiert wird, wurde die Nutzbarkeit von tagesgenauen Informationen zur Arbeitsunfähigkeit (AU) untersucht. Methodik Am Beispiel Rückenschmerzen (ICD M54) wurde mit TK-Routinedaten analysiert, bei wie vielen Versicherten eine potentiell nicht-indizierte radiologische Bildgebung erfolgte. Anstelle der

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Sawattep, Jeeranut, Thad A. Howard, Noppawan P. Morales, et al. "Single Nucleotide Polymorphism (SNP) Discovery within the UGT1A Gene Complex: Allelic Frequencies and Ethnic Differences." Blood 104, no. 11 (2004): 3780. http://dx.doi.org/10.1182/blood.v104.11.3780.3780.

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Abstract The UDP-glycosyltransferase (UGT1A) gene complex plays an important role in the hepatic metabolism of many chemicals, toxins, and drugs including bilirubin and acetaminophen. In this large gene complex that spans over 200kb, there are at least 13 different coding regions that can serve as exon 1, followed by a common sequence that contains exons 2–5. These variable exon 1 sequences confer different chemical specificities for binding compounds, while exons 2–5 provide glycosyltransferase function (glucuronidation) that enhances water solubility and excretion. Mutations and polymorphism

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Pisuitthanakan, MD, Satapong. "Comparison of the Posterior and Paraspinal Approaches for the Treatment of Thoracolumbar Burst Fractures: A Randomized Controlled Trial." Journal of Southeast Asian Orthopaedics 46, no. 1 (2022): 17–23. http://dx.doi.org/10.56929/jseaortho.v46i1.12.

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Purpose: Burst fractures cause over half of all thoracolumbar fractures, for which the posterior approach has been considered the standard approach. The paraspinal approach has proven safe and effective for thoracolumbar injury. This study aimed to compare the clinical and radiographic outcomes between the two approaches. Methods: This randomized controlled trial included 24 patients with isolated thoracolumbar burst fractures between July 2016 and August 2018. Patients were categorized into two groups: paraspinal and posterior approaches. The primary outcome was postoperative pain on days 1,

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D'yakova, Nina Alekseevna. "ACCUMULATION OF MACRO- AND MICROELEMENTS IN LEAVES OF STINGING NETTLE (URTICA DIOICA L.)." Ulyanovsk Medico-biological Journal, no. 2 (June 30, 2022): 139–47. http://dx.doi.org/10.34014/2227-1848-2022-2-139-147.

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Studies of the ultimate composition of wild-growing raw materials are relevant and significant due to the high efficiency and bioavailability of organometallic forms contained in plants. However, the available information on the content of elements in the medicinal plant raw materials in the Voronezh region concerns only a few elements. The lack of information does not allow us to determine the complete chemical composition of plants and to describe how the entire complex of mineral substances is accumulated in them. The aim of the study is to examine how macro- and trace elements are ac

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Ray, Chester A., and Kathryn H. Gracey. "Augmentation of exercise-induced muscle sympathetic nerve activity during muscle heating." Journal of Applied Physiology 82, no. 6 (1997): 1719–33. http://dx.doi.org/10.1152/jappl.1997.82.6.1719.

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Ray, Chester A., and Kathryn H. Gracey. Augmentation of exercise-induced muscle sympathetic nerve activity during muscle heating. J. Appl. Physiol. 82(6): 1719–1725, 1997.—The muscle metabo- and mechanoreflexes have been shown to increase muscle sympathetic nerve activity (MSNA) during exercise. Group III and IV muscle afferents, which are believed to mediate this response, have been shown to be thermosensitive in animals. The purpose of the present study was to evaluate the effect of muscle temperature on MSNA responses during exercise. Eleven subjects performed ischemic isometric handgrip at

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Karampinos, Dimitrios C., Christian Holwein, Stefan Buchmann, et al. "Proton Density Fat-Fraction of Rotator Cuff Muscles Is Associated With Isometric Strength 10 Years After Rotator Cuff Repair: A Quantitative Magnetic Resonance Imaging Study of the Shoulder." American Journal of Sports Medicine 45, no. 9 (2017): 1990–99. http://dx.doi.org/10.1177/0363546517703086.

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Background: Quantitative muscle fat-fraction magnetic resonance (MR) imaging techniques correlate with semiquantitative Goutallier scores with failure after rotator cuff (RC) repair. Purpose: To investigate the relationship of proton density fat fraction (PDFF) of the RC muscles with semiquantitative MR scores, cartilage T2 relaxation times, and clinical isometric strength measurements in patients 10 years after unilateral RC repair. Study Design: Cross-sectional study; Level of evidence, 3. Methods: Bilateral shoulder MR imaging was performed in 13 patients (11 male, 2 female; age, 72 ± 8 yea

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Kapus, Jernej, Igor Mekjavic, Adam McDonnell, et al. "Cardiorespiratory Responses of Adults and Children during Normoxic and Hypoxic Exercise." International Journal of Sports Medicine 38, no. 08 (2017): 627–36. http://dx.doi.org/10.1055/s-0043-109376.

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AbstractWe aimed to elucidate potential differential effects of hypoxia on cardiorespiratory responses during submaximal cycling and simulated skiing exercise between adults and pre-pubertal children. Healthy, low-altitude residents (adults, N=13, Age=40±4yrs.; children, N=13, age=8±2yrs.) were tested in normoxia (Nor: PiO2=134±0.4 mmHg; 940 m) and normobaric hypoxia (Hyp: PiO2=105±0.6 mmHg; ~3 000 m) following an overnight hypoxic acclimation (≥12-hrs). On both days, the participants underwent a graded cycling test and a simulated skiing protocol. Minute ventilation (VE), oxygen uptake (VO2),

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Long, Kelvin. "Application of the HeliosX ICF Advanced Propulsion Mission Analysis Code to Perturbed Interstellar Design Models." Journal of the British Interplanetary Society 76, no. 3 (2023): 94–111. http://dx.doi.org/10.59332/jbis-076-03-0094.

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HeliosX is a system integrated programming design tool which has the purpose of calculating spacecraft mission profile and propulsion performance for inertial confinement fusion (ICF) driven designs. This code uses the vehicle configuration input and capsule assumptions and then calculates the likely mission profile for a given destination target. The key technology is the inclusion of the fusion propulsion system and an adequate modelling of its likely energy outputs. This paper discusses calculations for perturbed design concepts from a baseline model in both series and parallel thrust mode.

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Puteri, Ni Made Martini, Hamdi Muluk, Amarina Ariyanto, and Bagus Takwin. "THE MEANING OF GRATIFICATION, MORAL CREDENTIAL, AND THE VALUE OF SELFLESSNESS ACTION IN VIOLATIONS COMMITTED BY A RESPECTED PERSON." Jurnal Psikologi 19, no. 4 (2020): 373–87. http://dx.doi.org/10.14710/jp.19.4.373-387.

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This study aims to prove how kindness conducted by the group, the definition of violations and the value of doing good, can affect moral credential in the form of the leniency of punishment for corruptors. Sample 319 polices and doctors divided into two segments. This study uses a population-based survey experiment method. Participants divided into moral credential with the narrative noble duty, and non-moral credential with neutral narratives. Researchers require each participant to provide criminal punishment and social reactions to the vignette of violation cases due to receiving gratificat

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Thompson, John A., D. Gary Gilliland, Josef T. Prchal, et al. "Effect of recombinant human erythropoietin combined with granulocyte/ macrophage colony-stimulating factor in the treatment of patients with myelodysplastic syndrome." Blood 95, no. 4 (2000): 1175–79. http://dx.doi.org/10.1182/blood.v95.4.1175.004k51_1175_1179.

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This randomized, placebo-controlled trial was designed to assess the efficacy and safety of therapy with granulocyte-macrophage colony-stimulating factor (GM-CSF) and erythropoietin (epoetin alfa) in anemic, neutropenic patients with myelodysplastic syndrome. Sixty-six patients were enrolled according to the following French–American–British classification: refractory anemia (20), refractory anemia with excess blasts (35), refractory anemia with ringed sideroblasts (9), and refractory anemia with excess blasts in transformation (2). Patients were stratified by their serum erythropoietin levels

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Choueiri, Toni K., Todd Michael Bauer, Jaime R. Merchan, et al. "Updated results from the phase 2 LITESPARK-003 study of belzutifan plus cabozantinib in patients with advanced clear cell renal cell carcinoma (ccRCC)." Journal of Clinical Oncology 43, no. 5_suppl (2025): 549. https://doi.org/10.1200/jco.2025.43.5_suppl.549.

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549 Background: In the phase 2 LITESPARK-003 study (NCT03634540), belzutifan plus cabozantinib showed antitumor activity in patients with advanced ccRCC who were treatment-naive (cohort 1) or previously treated (cohort 2). We present updated results from cohorts 1 and 2 with a median follow-up of 34.4 months and 49.9 months, respectively. Methods: Eligible patients had advanced or metastatic ccRCC and ECOG performance status of 0 or 1. Cohort 1 included patients with no prior systemic therapy. Cohort 2 included patients who had received prior immunotherapy and ≤2 systemic regimens. Starting do

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Guler, Sevil, Gulcan Eyuboglu, Zehra Gocmen Baykara, et al. "The Effect of Stoma Site Marking on Stomal Complications: A Long-term Retrospective Study." Advances in Skin & Wound Care 37, no. 5 (2024): 254–59. http://dx.doi.org/10.1097/asw.0000000000000134.

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ABSTRACT OBJECTIVE To identify the effect of stoma site marking on stoma-related complications. METHODS The study sample included 639 individuals with stomas who were followed up in a stomatherapy unit in Turkey between January 1, 2017, and June 20, 2021. Researchers collected patient data from nursing records. Data were evaluated using number, percentage, χ 2, and logistic regression tests. RESULTS Of the individuals with stomas, 60.6% (n = 387) were men, and 72.6% (n = 464) had a cancer diagnosis. Their mean age was 60.16 (SD, 14.81) years. The stoma site was marked preoperatively in of 67.1

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Fleischmann, R., M. C. Genovese, K. Maslova, H. Leher, A. Praestgaard, and G. R. Burmester. "FRI0092 LONG-TERM SAFETY AND EFFICACY OF SARILUMAB OVER 5 YEARS IN PATIENTS WITH RHEUMATOID ARTHRITIS REFRACTORY TO TUMOR NECROSIS FACTOR INHIBITORS." Annals of the Rheumatic Diseases 79, Suppl 1 (2020): 624–25. http://dx.doi.org/10.1136/annrheumdis-2020-eular.1946.

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Background:Sarilumab is a human IL-6 receptor (IL-6R) inhibitor approved for the treatment of adults with moderate to severely active rheumatoid arthritis (RA). In the TARGET study (NCT01709578), sarilumab plus conventional synthetic disease-modifying antirheumatic drugs (DMARDs) significantly improved signs and symptoms of RA and physical function versus placebo in patients refractory to tumor necrosis factor (TNF) inhibitors.Objectives:Here we report the long-term safety and efficacy of subcutaneous (SC) sarilumab over 5 years in patients who continued treatment in the open-label extension s

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Loyaux, Romain, Julien Hadoux, Sandrine Oziel, et al. "Emergence of DNA Damage Repair Clonal Hematopoiesis after Peptide Receptor Radionuclide Therapy for Neuroendocrine Tumors." Blood 144, Supplement 1 (2024): 1289. https://doi.org/10.1182/blood-2024-204958.

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Background . In advanced/metastatic neuroendocrine tumors (NETs), PRRT (Peptide Receptor Radionuclide Therapy), has shown efficacy but with significant hematologic toxicity, including therapy-related myeloid neoplasms (t-MN). Here, we assessed the effect of PRRT on the development of clonal hematopoiesis (CHIP) or clonal cytopenia of undetermined significance (CCUS) known to be a risk factor for t-MN development. Methods . We performed a targeted 77 genes mutational analysis using Next Generation Sequencing (NGS) in blood samples of 153 patients with metastatic gastroenteropancreatic (GEP) NET

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McRae, Hannah L., Markus Horchler, Nadine Schwarz, et al. "Higher D-Dimer and Prothrombin Fragment 1+2 in Patients Taking Direct Oral Anticoagulants As Compared to Vitamin K Antagonists." Blood 144, Supplement 1 (2024): 1251. https://doi.org/10.1182/blood-2024-210238.

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Introduction: A central question regarding anticoagulant treatment of venous thromboembolism (VTE) is how long maintenance therapy should be continued. Current decision algorithms, which were developed during the era of vitamin K antagonists (VKA), are based on D-dimer measurements before and/or after discontinuation of anticoagulants. However, recent clinical data from the Apidulcis study questioned the validity of this approach in patients taking direct oral anticoagulants (DOACs). One reason for this may be generally higher D-dimer levels in patients on DOACs than in those on VKAs, for whic

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Cao, Meiwan, Yayoi Shikama, Michiko Anzai, and Junko Kimura. "Impaired Neutrophil Migration Resulting from Mir-34a and Mir-155 Overexpressed in Neutrophils from Myelodysplastic Syndrome Patients." Blood 126, no. 23 (2015): 999. http://dx.doi.org/10.1182/blood.v126.23.999.999.

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Abstract In myelodysplastic syndromes (MDS), functional defects of neutrophils result in high mortality due to infections. However, the molecular basis of neutrophil dysfunction remains unclear. We recently found that miR-34a and miR-155 were significantly increased in MDS neutrophils. To determine the effects of the aberrant expression of the microRNAs on neutrophil functions, HL60 cells, in which miR-34a, miR-155 or control microRNA was ectopically introduced by electroporation, were cultured in the presence of 500 μM dibutyryl cyclic AMP for 2 days to induce differentiation toward a neutrop

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Petrova, Milla, Mariyana Eneva, Jeliazko Iliev Arabadjiev, et al. "High neutrophil to lymphocyte ratio as a predictor for hyperprogressive disease in patients with metastatic non-small cell lung cancer treated with pembrolizumab as a second line." Journal of Clinical Oncology 38, no. 15_suppl (2020): e21546-e21546. http://dx.doi.org/10.1200/jco.2020.38.15_suppl.e21546.

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e21546 Background: In this study we evaluated the incidence of early non-responders (which are potential hyper-progressors (HP)) and its relation to Neutrophil-Lymphocyte Ratio (NLR), Platelet-Lymphocyte Ratio (PLR) as well as their dynamics in patients with Non-small Cell Lung Cancer (NSCLC) treated with pembrolizumab (P) as a second line. Methods: Patients with metastatic NSCLC (n=119) whose tumors expressed PD-L1≥1% were retrospectively analyzed between Apr 2017 and Oct 2019. All patients received platinum-containing chemotherapy (CT) as a first line treatment. Hematological parameters of i

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Nolan, Annette L., Christine C. Allen, Robert C. Burns, Donald C. Craig, and Geoffrey A. Lawrance. "Monomeric and Dimeric Cobalt(III) Polyoxomolybdates: Crystal Structures and Cyclic Voltammetry of Na3 [H6CoMo6O24].8H2O and K6 [H4Co2Mo10O38].7H2O." Australian Journal of Chemistry 51, no. 9 (1998): 825. http://dx.doi.org/10.1071/c97218.

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The crystal structures of Na3 [H6CoMo6O24].8H2O and K6 [H4Co2Mo10O38].7H2O have been determined by X-ray diffraction. The monomer, Na3 [H6CoMo6O24].8H2O, is triclinic, space group P-1, a 6·451(1), b 10·866(2), c 10·922(2) Å, α 109·20(1), β 106·90(1), γ 95·43(1)°, V 676·3(2) Å3, Z 1, and the structure was solved to an R1 value of 0·0243 (wR2 0·0784) for 3761 independent observed reflections. The anion exhibits the well known Anderson structure with six octahedral MoO6 edge-sharing units surrounding the central ‘CoO6’ octahedron, with all metals in a common plane. The dimer, K6 [H4Co2Mo10O38].7H

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Motoyama, Takeshi, Hiroaki Kawano, Kiyotaka Kugiyama, et al. "Endothelium-dependent vasodilation in the brachial artery is impaired in smokers: effect of vitamin C." American Journal of Physiology-Heart and Circulatory Physiology 273, no. 4 (1997): H1644—H1650. http://dx.doi.org/10.1152/ajpheart.1997.273.4.h1644.

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Cigarette smoking has been shown to cause endothelial dysfunction. To examine the effects of vitamin C and cigarette smoking on endothelium-dependent vasodilation, we measured the lumen diameter and flow velocity of the brachial arteries at rest, during reactive hyperemia following transient arterial occlusion, and after sublingual nitroglycerin (0.3 mg) in smokers ( n = 20) and nonsmokers ( n = 20) with high-resolution ultrasound after infusion of saline or saline plus vitamin C (10 mg/min for 20 min). We also performed the same study in smokers ( n = 15) before and 10 min after cigarette smo

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Sorokina, L., I. Avrusin, R. Raupov, et al. "POS1299 RISK FACTORS OF TOTAL HIP ARTHROPLASTY IN JUVENILE ARTHRITIS WITH HIP INVOLVEMENT." Annals of the Rheumatic Diseases 80, Suppl 1 (2021): 931–32. http://dx.doi.org/10.1136/annrheumdis-2021-eular.857.

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Background:Hip osteoarthritis (HOA) is a severe outcome of juvenile idiopathic arthritis (JIA) itself and also can be result of corticosteroid (CS) treatment, if it was used. Total hip arthroplasty (THA) is the last step in JIA treatment and indicates ineffectiveness of conservative treatment.Objectives:We aimed to evaluate risk factors which lead to THA in JIA patients with HOA.Methods:753 patients aged 2-17 years were included in our retrospective study during the last 10 years. Diagnosis was made according to ILAR criteria. Clinical, laboratory and radial examinations were evaluated. Diagno

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Bandini, L. G., D. A. Schoeller, J. Edwards, V. R. Young, S. H. Oh, and W. H. Dietz. "Energy expenditure during carbohydrate overfeeding in obese and nonobese adolescents." American Journal of Physiology-Endocrinology and Metabolism 256, no. 3 (1989): E357—E367. http://dx.doi.org/10.1152/ajpendo.1989.256.3.e357.

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Basal metabolic rate (BMR), thermic effect of food (TEF), and total daily energy expenditure (TDEE) were measured in six nonobese and seven obese adolescents during periods of weight maintenance and 2 wk of carbohydrate overfeeding. BMR and TEF were measured by indirect calorimetry and TDEE by the doubly labeled water method. Fasting blood levels of insulin, thyroid, and norepinephrine (NE) and urinary excretion of NE and 4-hydroxy-3-methoxymandelic acid (VMA) were measured before and after overfeeding. Energy intake was 1.61 X BMR during maintenance and 2.45 X BMR during overfeeding. BMR incr

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Roaldsnes, Christina, Anders Waage, Mette Nørgaard, and Waleed Ghanima. "Epidemiology of Myeloproliferative Neoplasms in Norway." Blood 124, no. 21 (2014): 1858. http://dx.doi.org/10.1182/blood.v124.21.1858.1858.

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Abstract Background: Polycythemia vera (PV), essential thrombocythemia (ET) and myelofibrosis (MF) are clonal hematological disorders collectively named as myeloproliferative neoplasms (MPN). Discovery of JAK2 mutation in 2005, altered WHO classification for MPN diagnosis in 2008 and availability of new treatment of MPN may have substantial effect on epidemiology of MPN. Published data on epidemiology of MPN after the discovery of JAK2 mutation and the introduction of 2008 WHO classifications for MPN, in particular on the prevalence of MPN, are scarce. We aimed to study the epidemiology of MPN

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