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Journal articles on the topic '159.947.24 (043.2)'

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Published: 30 May 2022

Last updated: 31 July 2025

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1

BHANUSHALI, APARNA A., AASHISH CONTRACTOR, and BIBHU R. DAS. "Variant at 9p21 rs1333049 is associated with age of onset of coronary artery disease in a Western Indian population: a case control association study." Genetics Research 95, no. 5 (2013): 138–45. http://dx.doi.org/10.1017/s0016672313000189.

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SummaryThe 9p21 chromosomal region has been associated with coronary artery disease (CAD) in many genome wide association studies (GWAS). To date no information exists regarding the rs1333039 SNP which showed the strongest association in the WTCCC GWAS with CAD risk in the Indian population. The present study attempts to replicate the findings in the Indian population.Genotyping for rs1333049 was done in 229 cases and 151 controls by allele-specific real-time assay.A higher frequency of the risk allele rs1333049C was seen in cases (0·60) as compared with controls (0·49), which associated with

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Semenova, Lioubov I., and Allan H. White. "Structural Systematics of Rare Earth Complexes. XIX (Hydrated) 1 : 2 Mononuclear Adducts of Lanthanoid(III) Chlorides with 2,2′-Bipyridine and 1,10-Phenanthroline." Australian Journal of Chemistry 52, no. 6 (1999): 571. http://dx.doi.org/10.1071/ch98052.

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Room-temperature single-crystal X-ray structure determinations are recorded for a number of adducts of hydrated lanthanoid(III) trichlorides with 2,2′-bipyridine (‘bpy’) and 1,10-phenanthroline (‘phen’), crystallized from water, methanol or ethanol solutions, containing mononuclear arrays with 1 : 2 Ln/bpy or phen stoichiometry. LaCl3/phen/H2O(1 : 3 : 9), [(phen)2La(OH2)5]Cl3.phen.4H2O, although of overall 1 : 3 LaCl3/phen stoichiometry, has a lattice phen; it is orthorhombic, Pnna, a 19·947(7), b 16·457(5), c 12·213(2) Å, Z = 4; conventional R on |F| was 0·030 for No 2567 ‘observed’ (I >3σ

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Kaye, S. B., J. Paul, J. Cassidy, et al. "Mature results of a randomized trial of two doses of cisplatin for the treatment of ovarian cancer. Scottish Gynecology Cancer Trials Group." Journal of Clinical Oncology 14, no. 7 (1996): 2113–19. http://dx.doi.org/10.1200/jco.1996.14.7.2113.

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PURPOSE In 1992, we reported the first results of a randomized study in ovarian cancer, comprising two doses of cisplatin and indicated a significant difference (P = .0008) in median survival. Four years later, we now describe the results of this trial. PATIENTS AND METHODS After a median follow-up of 4 years and 9 months, 115 of 159 cases of advanced ovarian cancer, originally randomized to receive six cycles of cyclophosphamide 750 mg/m2 and either a high dose (HD) of 100 mg/m2 cisplatin or a low dose (LD) of 50 mg/m2 (LD) cisplatin, have now died. RESULTS The overall survival for HD and LD

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Chao, Po-Kuan, Shau-Hua Ueng, Li-Chin Ou, et al. "1-(2,4-Dibromophenyl)-3,6,6-trimethyl-1,5,6,7-tetrahydro-4H-indazol-4-one." Anesthesiology 126, no. 5 (2017): 952–66. http://dx.doi.org/10.1097/aln.0000000000001568.

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Abstract Background The authors investigated the pharmacology and signaling pathways of the opioid receptors modulated by compound 1, 1-(2,4-dibromophenyl)-3,6,6-trimethyl-1,5,6,7-tetrahydro-4H-indazol-4-one. Methods In vitro studies of compound 1 were assessed by using a radioligand-binding assay (n = 3), a cyclic adenosine monophosphate assay (n = 3), a β-arrestin assay (n = 3), an internalization assay (n = 3), and an immunohistochemistry (n = 8). In vivo studies of compound 1 were characterized using a tail-flick test (n = 5 to 6), tail-clip test (n = 7), von Frey hair test (n = 5), and ch

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Patel, Priti, Mayra Telesca, and De-Hui Ku. "The Comparison of Fibrin Monomer (FM) Performance to Other Activation Markers (TAT, PF1.2 and DD)." Blood 118, no. 21 (2011): 5259. http://dx.doi.org/10.1182/blood.v118.21.5259.5259.

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Abstract Abstract 5259 In this study, we attempted to determine the performance of the soluble fibrin monomer complex (SFMC) test in comparison to known activation markers, such as prothrombin fragment 1.2 (PF1.2), thrombin antithrombin complex (TAT) and d-dimer (DD). We have used the STA(R)-Liatest FM and STA(R)-Liatest D-Di kits to measure the SFMC and d-dimer levels. A total of 25 patients were included in this study. The data and demographic information are shown in the table below. ID GENDER AGE FM TAT PF1.2 D-dimer 1 M 66 0.42 2.3 1988 0.05 2 F 31 27.93 >60.0 >12000 2.39 3 F 24 3.4

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Zhao, Wenxin, Yu Zhao, Yu Zheng, et al. "Long-term variability in black carbon emissions constrained by gap-filled absorption aerosol optical depth and associated premature mortality in China." Atmospheric Chemistry and Physics 24, no. 11 (2024): 6593–612. http://dx.doi.org/10.5194/acp-24-6593-2024.

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Abstract. Black carbon (BC) plays an important role in air quality, public health, and climate, but its long-term variations in emissions and health effects have been insufficiently understood for China. Here, we present the spatiotemporal evolution of BC emissions and the associated premature mortality in China during 2000–2020 based on an integrated framework combining satellite observations from the Ozone Monitoring Instrument (OMI), an extreme gradient boosting (XGBoost) algorithm, a “top-down” inversion approach, and an exposure–response model. We found that the “bottom-up” approach most

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De La Cerda, Jose, Laurence Belkoff, Kevin Dale Courtney, et al. "Safety and tolerability of relugolix in combination with abiraterone or apalutamide for treatment of advanced prostate cancer: Data from a 52-week clinical trial." Journal of Clinical Oncology 43, no. 5_suppl (2025): 156. https://doi.org/10.1200/jco.2025.43.5_suppl.156.

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156 Background: Relugolix (REL) is the only oral androgen deprivation therapy (ADT) indicated for advanced prostate cancer (aPC). Combining ADT with androgen receptor signaling inhibitors (ARSIs) has shown improved clinical outcomes in hormone-sensitive and castration-resistant PC. This study evaluated the safety and tolerability of REL with the ARSIs abiraterone (ABI) or apalutamide (APA). Methods: In this open-label, two-part study, patients (pts) with aPC, including ADT-experienced, were treated for 52 weeks (wks). In Part 1, pts received REL 120 mg qd + ABI 1000 mg qd + either prednisone 5

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van Velzen-Ball, Lynne Margaret, Marie Ester Bernado, Franco Locatelli, et al. "Co-Transplantation of Haploidentical Bone Marrow Derived Mesenchymal Stem Cells Overcomes Graft Dysfunction and Improves Hematological and Lymphocyte Recovery in Haploidentical Stem Cell Transplantation." Blood 108, no. 11 (2006): 3118. http://dx.doi.org/10.1182/blood.v108.11.3118.3118.

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Abstract Haploidentical peripheral blood stem cell transplantation from a parent is an accepted form of therapy in children lacking a suitable donor who require stem cell transplantation. The risk of graft failure/rejection increases with the intense T cell depletion resulting from positive CD34 selection. Mesenchymal stem cells (MSCs) isolated from bone marrow can be expanded to sufficient numbers for clinical use. MSCs can improve hematological recovery but their role in overcoming graft dysfunction post transplant is unknown. We present results of co-transplantation of MSCs in children unde

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Martynova, A., T. Popkova, A. Aleksankin, and E. Gerasimova. "AB0068 B- AND T- LYMPHOCYTE SUBSETS IN PATIENTS WITH EARLY AND PROGRESSED RHEUMATOID ARTHRITIS." Annals of the Rheumatic Diseases 80, Suppl 1 (2021): 1064.2–1065. http://dx.doi.org/10.1136/annrheumdis-2021-eular.3816.

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Background:Role of B- and T- lymphocytes is well established in pathogenesis of rheumatoid arthritis (RA). Self-containing activation of B-cells in ectopic germinative centers is followed by auto-activation of T-lymphocytes while T-cells themselves are antigen-presenting cells for B-lymphocytes [1-2]. As these processes continue with the duration of RA, different subsets of B- and T-cell might be prevalent at different stages of RA.Objectives:Evaluate differences in dynamics of B- and T- cell subsets in early and progressed RA.Methods:53 patients with diagnosed RA(ACR/EULAR 2010 criteria) were

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Camela, E. S. C., R. P. Nociti, V. J. C. Santos, et al. "151 Associations of Testicular Size and Arterial Blood Flow with Sexual Development and Semen Characteristics in Dorper Rams Raised in a Subtropical Climate." Reproduction, Fertility and Development 30, no. 1 (2018): 215. http://dx.doi.org/10.1071/rdv30n1ab151.

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Spectral Doppler (velocimetric) indices are important indicators of blood perfusion and physiological status of internal organs. Doppler ultrasound is used in andrology to assess the blood flow in the testicular arteries, aiding in the diagnosis of scrotal disorders and abnormal spermatogenesis. It was proposed that blood flow indices measured in the testicular artery, namely, blood flow resistance and pulsatility index, were significant predictors of semen quality in clinically healthy dogs. There is a paucity of studies on the associations of testicular morphology and blood flow dynamics wit

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Devarajulu, Kavitha, and Prabu Velusamy. "A study of etiology, clinical profile and outcome in children aged 1-12 years presenting with fever of 1-3 weeks duration in a tertiary hospital." International Journal of Contemporary Pediatrics 6, no. 2 (2019): 569. http://dx.doi.org/10.18203/2349-3291.ijcp20190073.

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Background: The objective of the study was to find out the etiology, associated signs and symptoms of fever of 1-3 weeks in the age group of 1-12 years and their outcome following treatment in a tertiary care hospital.Methods: This was an observational prospective study conducted at Institute of child health and hospital for children, Egmore, Chennai during the period from January 2011 to October 2012. A total of 621 children aged 1-12 years with 1-3 weeks of fever were included in the study. Demographic, clinical and diagnostic data were collected and analyzed for each patient and outcome was

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Sitdykov, R. M., E. N. Shaidullin, and A. Y. Zubkov. "Choosing the surgical treatment method for benign prostatic hyperplasia." Kazan medical journal 94, no. 3 (2013): 409–12. http://dx.doi.org/10.17816/kmj2196.

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Aim. To assess the surgical treatment outcomes for benign prostatic hyperplasia. Methods. The surgical treatment outcomes for benign prostatic hyperplasia were analyzed in 72 patients. 44 patients underwent transvesical prostatectomy ended with blind urinary bladder stitch, 28 patients with a prostate volume of less than 60 ml were offered transurethral resection of prostate. The patients’ mean age was 73.6 years. Inclusion criteria were: average urination flow rate (Qav) 10 ml/sec, total international prostate symptom score (I-PSS) 19, residual urine volume 50 ml. Prostate volume ranged from

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Cappellini, Maria Domenica, Mohsen Saleh Elalfy, Antonis Kattamis та ін. "Efficacy and Safety of Once-Daily, Oral Iron Chelator Deferasirox (Exjade®) in a Large Group of Regularly Transfused Patients with β-Thalassemia Major". Blood 112, № 11 (2008): 3878. http://dx.doi.org/10.1182/blood.v112.11.3878.3878.

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Abstract Background: The 1-year, prospective, multicenter EPIC trial, the largest ever conducted for an iron-chelating agent, evaluated the efficacy and safety of the once-daily, oral chelator deferasirox (Exjade®) in patients (pts) with transfusion-dependent anemias. 54% of 1744 pts had β-thalassemia major, providing one of the largest data sets assessing the use of deferasirox in this group. Data from this subgroup are presented. Methods: Pts (≥2 years old) with transfusional iron overload due to β-thalassemia and serum ferritin (SF) levels of ≥1000 ng/mL or <1000 ng/mL but with a history

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M, Woh Wei, and Chee Keong S. "HYPERGLYCAEMIC EMERGENCY ADMISSION, POST-DISCHARGE CARE AND 6-MONTHS OUTCOME IN HOSPITAL BENTONG." Journal of the ASEAN Federation of Endocrine Societies 34 (July 17, 2019): 20–21. https://doi.org/10.15605/jafes.034.s28.

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INTRODUCTIONDiabetic ketoacidosis (DKA) and hyperglycemic hyperosmolar state (HHS) are two acute complications of diabetes with increased morbidity and mortality if not treated appropriately. Outcome and follow-up care of patients after recovery and discharge for DKA/HHS is relatively under-reported and unknown. The aim of this study was to assess DKA and HHS admission and postdischarge care and outcome. METHODOLOGYThis is a cross-sectional study including all patients with DKA and HHS admitted to Hospital Bentong from January 2017 to December 2018. Clinical records were reviewed for demograph

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Park, Junghyun, and Marc Rodger. "Retrospective Cohort of Unprovoked Venous Thromboembolism Patients: What Proportion Have Potent Thrombophilias Necessitating Indefinite Anticoagulants?" Blood 126, no. 23 (2015): 2318. http://dx.doi.org/10.1182/blood.v126.23.2318.2318.

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Introduction Thrombophilia testing in unprovoked venous thromboembolism patients (VTE) is controversial. Common thrombophilias such as Factor V Leiden or prothrombin gene variant appear to not importantly increase the risk of VTE recurrence, and thus are not considered in anticoagulation management decisions. However, patients with potent thrombophilias such as antiphospholipid antibodies (APLA), antithrombin deficiency, protein C and S deficiency, and homozygous genetic thrombophilias or combined defects are at higher risk of recurrence and it is recommended that they receive long-term antico

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Geissler, Kimberley H., Meng-Shiou Shieh, Jerry A. Krishnan, Peter K. Lindenauer, Arlene S. Ash, and Sarah L. Goff. "Health Insurance Type and Outpatient Specialist Care Among Children With Asthma." JAMA Network Open 7, no. 6 (2024): e2417319. http://dx.doi.org/10.1001/jamanetworkopen.2024.17319.

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ImportanceAlthough children with asthma are often successfully treated by primary care clinicians, outpatient specialist care is recommended for those with poorly controlled disease. Little is known about differences in specialist use for asthma among children with Medicaid vs private insurance.ObjectiveTo examine differences among children with asthma regarding receipt of asthma specialist care by insurance type.Design, Setting, and ParticipantsIn this cross-sectional study using data from the Massachusetts All Payer Claims Database (APCD) between 2014 to 2020, children with asthma were ident

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Lin, Chih-Lung, Aaron S. Dumont, Ann-Shung Lieu, et al. "Characterization of perioperative seizures and epilepsy following aneurysmal subarachnoid hemorrhage." Journal of Neurosurgery 99, no. 6 (2003): 978–85. http://dx.doi.org/10.3171/jns.2003.99.6.0978.

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Object. The reported incidence, timing, and predictive factors of perioperative seizures and epilepsy after subarachnoid hemorrhage (SAH) have differed considerably because of a lack of uniform definitions and variable follow-up periods. In this study the authors evaluate the incidence, temporal course, and predictive factors of perioperative seizures and epilepsy during long-term follow up of patients with SAH who underwent surgical treatment. Methods. Two hundred seventeen patients who survived more than 2 years after surgery for ruptured intracranial aneurysms were enrolled and retrospectiv

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Castrejon, I., J. Molina Collada, C. Perez-Garcia, et al. "POS1439 CANCER IN PATIENTS WITH RHEUMATIC DISEASES EXPOSED TO DIFFERENT BIOLOGIC AND TARGETED SYNTHETIC DMARDS IN REAL-WORLD CLINICAL PRACTICE: DATA FROM A MULTICENTER REGISTER." Annals of the Rheumatic Diseases 81, Suppl 1 (2022): 1063. http://dx.doi.org/10.1136/annrheumdis-2022-eular.3834.

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BackgroundExtensive evidence has confirmed no increased risk of cancer associated to either conventional synthetic DMARDs or anti-TNF in patients with rheumatic diseases. The risk of cancer in biologic (bDMARDs) different to anti-TNF and targeted synthetic (tsDMARDs) is considerably less investigated. As new therapies are emerging, more data in real-world registries are needed to confirm safety in other treatment groups.ObjectivesTo compare the risk of cancer of tsDMARDs and other bDMARDs versus anti-TNF in patients with rheumatic diseases.MethodsData of patients enrolled in BIOBADASER 3.0 up

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Gill, Harinder, Lester Au, Dorothy Tsai, et al. "Bomedemstat (MK3543) in Combination with Ruxolitinib in Patients with Advanced Myelofibrosis." Blood 144, Supplement 1 (2024): 1796. https://doi.org/10.1182/blood-2024-208038.

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Background Approximately 50% of patients with myelofibrosis (MF) discontinue ruxolitinib after 3 years, mostly due to disease progression, suboptimal response or cytopenia. Outcome after ruxolitinib discontinuation is poor with a median overall survival (OS) of approximately 14 months. Lysine-specific demethylase-1 (LSD1) is a histone demethylase critical for self-renewal of malignant hematopoietic stem cells and for maturation of progenitor cells. Bomedemstat is an oral LSD1 inhibitor clinically active in patients with myeloproliferative neoplasms (MPN) and has shown clinical activity as a si

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Volkmann, E., Z. Mcmahan, S. Johnson, et al. "POS0840 RISK OF MALNUTRITION IN PATIENTS WITH SYSTEMIC SCLEROSIS-ASSOCIATED INTERSTITIAL LUNG DISEASE (SSC-ILD): FURTHER ANALYSES OF THE SENSCIS TRIAL." Annals of the Rheumatic Diseases 80, Suppl 1 (2021): 674.1–674. http://dx.doi.org/10.1136/annrheumdis-2021-eular.1083.

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Background:Gastrointestinal (GI) involvement is common in patients with SSc and may lead to weight loss and malnutrition. In the SENSCIS trial in patients with SSc-ILD, nintedanib reduced the rate of decline in forced vital capacity (FVC) (mL/year) over 52 weeks, with mainly GI adverse events. The Malnutrition Universal Screening Tool (MUST) was developed to identify adults who are at risk of malnutrition and has been used in studies of patients with SSc.Objectives:To evaluate nutritional status over 52 weeks in the SENSCIS trial based on a modified MUST score.Methods:The SENSCIS trial enrolle

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Massarelli, Erminia, Ani Sarkis Balmanoukian, Maria Vieito, et al. "INDUCE-1: Report on safety run-in cohorts combining Inducible T-cell co-stimulatory receptor (ICOS) agonist GSK3359609 (GSK609) with platinum+5-FU chemotherapy (5-FU/plat), with or without pembrolizumab (PE), for the treatment of advanced solid tumors." Journal of Clinical Oncology 38, no. 15_suppl (2020): 6544. http://dx.doi.org/10.1200/jco.2020.38.15_suppl.6544.

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6544 Background: The KEYNOTE-048 study (Burtness, at al. Lancet 2019;394:1915–28) led to approval of PE in combination with 5-FU/plat for first-line (1L) treatment of head and neck squamous cell carcinoma (HNSCC). The Phase I INDUCE-1 study (NCT02723955) has shown that GSK609±PE has a manageable safety profile in patients (pts) with advanced solid tumors (Hansen, at al. Annals of Oncology 2018;29[suppl_8]:viii404) and that GSK609 combined with PE has anti-tumor activity in pts with anti-PD-1/L1-naïve HNSCC (Rischin, et al. Annals of Oncol 2019;30[Supplement_5]:v454–5). To evaluate the safety o

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Bolotskaya, L. L., E. G. Bessmertnaya, M. V. Shestakova, et al. "A 20-year prospective follow-up study to evaluate the development of retinopathy and nephropathy after the onset of type 1 diabetes mellitus: Contribution of glycemic control and metabolic memory." Terapevticheskii arkhiv 89, no. 10 (2017): 17–21. http://dx.doi.org/10.17116/terarkh2017891017-21.

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Aim. To assess the time course of changes in the level of glycated hemoglobin (HbA1c) for 20 years after the onset of type 1 diabetes mellitus (T1DM) and to compare its correlation with the development of microvascular complications, such as diabetic retinopathy (DR) and diabetic nephropathy (DN). Subjects and methods. A total of 187 children with new-onset T1DM were registered in Moscow in 1994. During the 20-year follow-up study, these patients underwent regular check-ups at the Endocrinology Research Center, Ministry of Health of the Russian Federation, which included assessment of physical

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Rivera Teran, V., D. Vega-Morales, S. Sicsik, et al. "AB0233 ONE YEAR RESPONSE AND ASSOCIATED FACTORS FOR REMISSION AND LOW ACTIVITY DISEASE IN PATIENTS WITH RHEUMATOID ARTHRITIS: DATA FROM THE MEXICAN BIOLOGICS REGISTRY." Annals of the Rheumatic Diseases 82, Suppl 1 (2023): 1301.2–1301. http://dx.doi.org/10.1136/annrheumdis-2023-eular.6458.

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BackgroundRheumatoid arthritis (RA) is the most common autoimmune disease. Clinical remission is the main therapeutic target for patients with RA, with low disease activity (LDA) as a best possible alternative[1].ObjectivesEvaluate clinical response of patients with RA treated with biologic (bDMARDs) and the associated factors for remission and low activity disease at the first year of treatment.MethodsBIOBADAMEX is a Mexican ongoing cohort of patients using bDMARDs since 2016. In this analysis we included all patients with diagnosis of RA with at least two assessments, baseline and at one yea

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Wagner, Jonathan, Melissa Ruggiero, J. Steven Leeder, and Bruno Hagenbuch. "3012 Functional consequences of pravastatin isomerization on OATP1B1-mediated transport." Journal of Clinical and Translational Science 3, s1 (2019): 107. http://dx.doi.org/10.1017/cts.2019.243.

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OBJECTIVES/SPECIFIC AIMS: In the present study, we examined the functional consequences of 3α-PVA on OATP1B1-mediated PVA transport. To elucidate this, we determined the effect of SLCO1B1 genotype on PVA transport and the role of 3αPVA as a competitive inhibitor of OATP1B1, which could serve as another covariate that disrupts the systemic and hepatic exposure of pravastatin in children and adults. METHODS/STUDY POPULATION: Site directed mutagenesis was performed to generate SLCO1B1 genotypes of interest (*1a, *1b, *5, *15). Human embryonic kidney (HEK293) cells were grown and plated at 200 000

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Ciurea, Stefan O., Rima M. Saliba, Gabriela Rondon, et al. "Superior Outcomes with Matched Unrelated Donors Compared with One Human Leukocyte Antigen Mismatched Related Donors In Allogeneic Hematopoietic Stem Cell Transplantation." Blood 116, no. 21 (2010): 907. http://dx.doi.org/10.1182/blood.v116.21.907.907.

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Abstract Abstract 907 Most candidates for hematopoietic stem cell transplantation lack a human leukocyte antigen (HLA)-identical sibling donor; however, many patients may have a related donor with whom they are mismatched at one antigen/allele. It is not known whether such a match is preferable to a matched unrelated donor (MUD). We hypothesized that, in transplantation using related donors, adding a single HLA antigen/allele mismatch, identified through high resolution HLA typing at HLA-A, -B, -C, -DRB1 and -DQB1, would be associated with worse outcomes than transplantation using matched unre

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Wildenboer, Johan. "JOSHUA 24: SOME LITERARY AND THEOLOGICAL REMARKS." Journal for Semitics 24, no. 2 (2017): 484–502. http://dx.doi.org/10.25159/1013-8471/3465.

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Achenbach, R 2005. Pentateuch, Hexateuch und Enneateuch. Eine Verhältnisbestimmung, ZAR 11:122–154. Albertz, R 2007. Die kanonische Anpassung des Johuabuches. Ein Neubewertung seiner sog.”Priesterschriftelike Texte”, in Römer and Schmid 2007:199–217. Aurelius, E 2003. Zukunft jenseits des Gerichts: Eine redaktionsgeschichltliche Studie zumEnneateuch. BZAW 319. Berlin: de Gruyter. Barrick, W B & Spencer, J R (eds) 1984. In the shelter of Elyon: essays on ancient Palestinian life in honour of GW Ahlström. JSOTSup 31. Sheffield: JSOT Press. Becker U, 2006. Endredaktionelle Kontextvernetzungen

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Essilini, Anaïs, Thibault Comont, Johanne Germain, et al. "Interest in Initiating Corticosteroids By Intravenous Methylprednisolone at Standard Dose in Newly Diagnosed Immune Thrombocytopenia Adults: Results of the Prospective Carmen Registry." Blood 128, no. 22 (2016): 3736. http://dx.doi.org/10.1182/blood.v128.22.3736.3736.

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Abstract Introduction . In France as in many other countries, first-line treatment of adult immune thrombocytopenia (ITP) is based on conventional dose (1 mg/kg/d) oral steroids (CDOS) during 3 weeks. Intravenous polyvalent immunoglobulin (IVIg) is added in case of severe bleeding. However, conventional dose (1 mg/kg/d) intravenous methylprednisolone (CDMP) is often used as a first-line treatment during a few days before continuation with oral prednisone. Indeed, CDMP may induce earlier response in comparison with CDOS due to the absence of intestinal absorption and of hepatic metabolism to be

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Manzi, S., C. Lindholm, I. Hupka, et al. "OP0282 IMPACT OF ANIFROLUMAB ON NEUROPSYCHIATRIC MANIFESTATIONS OF DEPRESSION AND SUICIDALITY IN PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS." Annals of the Rheumatic Diseases 81, Suppl 1 (2022): 187–88. http://dx.doi.org/10.1136/annrheumdis-2022-eular.894.

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BackgroundNeuropsychiatric (NP) disease is more common in patients with systemic lupus erythematosus (SLE) than in the general population.1 Increased incidence of NP events (depression and suicidality) has been reported with biologic therapies, including SLE therapies.2 Depression and suicidality were evaluated in patients with SLE treated with anifrolumab, a type I interferon receptor antibody, in the TULIP-1 and TULIP-2 trials.3,4ObjectivesTo understand the impact of anifrolumab treatment on NP manifestations (depression and suicidality) in patients with SLE relative to standard therapy usin

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Sandhu, Irwindeep, Paul G. Richardson, Albert Oriol, et al. "Mezigdomide (MEZI) Plus Dexamethasone (DEX) and Bortezomib (BORT) or Carfilzomib (CFZ) in Patients (pts) with Relapsed/Refractory Multiple Myeloma (RRMM): Updated Results from the CC-92480-MM-002 Trial." Blood 144, Supplement 1 (2024): 1025. https://doi.org/10.1182/blood-2024-198408.

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Introduction: MEZI is a novel, potent, oral CELMoD™ agent with enhanced tumoricidal and immune-stimulatory effects compared with immunomodulatory drugs (IMiDs®). Preclinically, MEZI has shown marked synergy with DEX and other antimyeloma therapies, including proteasome inhibitors (PIs). In the phase 1/2 CC-92480-MM-002 trial (NCT03989414), MEZI combined with DEX and BORT (MeziVd) or DEX and CFZ (MeziKd) showed meaningful clinical activity and manageable tolerability in pts with RRMM. Here we report updated results with longer follow-up from the MeziVd and MeziKd dose-escalation cohorts (A and

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Gupta, Bhanu P., Juan Leoni, Parag Patel, Dong Chen, and Joseph Blackshear. "A Comparison of Von Willebrand Factor Indexes in Heartmate II Compared to Heartware Left Ventricular Assist Devices." Blood 126, no. 23 (2015): 2306. http://dx.doi.org/10.1182/blood.v126.23.2306.2306.

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Abstract Background: Von Willebrand factor (VWF) is a multimeric glycoprotein synthesized in endothelium and megakaryocytes. Elevated total VWF antigen has been associated with arterial thrombosis, while in patients with left ventricular assist devices (LVAD), loss of high molecular weight multimers is associated with spontaneous bleeding. We hypothesized that the lower rotational speed of the Heartware LVAD would be associated with less severe disruption of VWF. Methods: A total of 22 patients were included. We compared samples from a) 17 patients with Heartmate II LVAD (HM II), 76% male, med

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Navarro, Jose-Tomas, Maria Joao Baptista, Alejandra Martinez-Trillos, et al. "Lymphomas With MYC-Translocation Other Than Burkitt’s Have An Aggressive Presentation and Poor Response To Immunochemotherapy: Study Of 34 Cases." Blood 122, no. 21 (2013): 5083. http://dx.doi.org/10.1182/blood.v122.21.5083.5083.

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Abstract Introduction MYC translocations involving chromosome 8q24 can occur in a wide variety of B-cell lymphomas other than Burkitt’s lymphoma (BL), especially diffuse large B-cell lymphoma (DLBCL) and B-cell lymphoma unclassifiable with intermediate features between DLBCL and BL (BCLU). These lymphomas can harbor additional translocations of BCL2 and/or BCL6, that have been referred to as double and triple-hit lymphomas. MYC positive lymphomas other than BL are not well characterized and the standard treatment has to be established. Aim The objective was to study the clinic-biological chara

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Sesin, C., G. Gallo, A. Gellett, et al. "POS1033 SAFETY OF IXEKIZUMAB IN PATIENTS WITH PSORIATIC ARTHRITIS: AN INTEGRATED ANALYSIS OF 4 CLINICAL TRIALS." Annals of the Rheumatic Diseases 80, Suppl 1 (2021): 789.1–789. http://dx.doi.org/10.1136/annrheumdis-2021-eular.567.

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Background:Patients with psoriatic arthritis (PsA) require long-term treatment, which may lead to adverse events (AEs). Ixekizumab, an interleukin-17A antagonist, is approved for the treatment of adults with active PsA.Objectives:We report a summary of safety outcomes for patients enrolled in 4 PsA studies with up to 3 years of exposure to ixekizumab.Methods:This integrated safety analysis included all patients with PsA who received at least 1 dose of ixekizumab (80 mg every 2 or 4 weeks) in 4 clinical trials (NCT01695239, NCT02349295, NCT02584855, NCT03151551). Safety outcomes included treatm

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Pleyer, Christopher, Surbhi Sidana, Tomas Radivoyevitch, et al. "Radioactive Iodine Treatment of Thyroid Cancer and Risk of Myelodysplastic Syndromes." Blood 126, no. 23 (2015): 612. http://dx.doi.org/10.1182/blood.v126.23.612.612.

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Abstract Background: The incidence of thyroid cancers has been rising in the United States primarily due to the increased detection of well differentiated thyroid cancers (WDTC). Radioactive iodine (RAI), which is frequently used to treat WDTC, can be considered a circulating radiation emitter with the potential for mutagenic effects on hematopoietic stem cells. With a growing number of WDTC patients (pts) surviving long term following RAI therapy, establishing the risk of developing a myelodysplastic syndrome (MDS) in this cohort has important clinical implications. Methods: A novel R program

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Nazha, Aziz, Tomas Radivoyevitch, David J. Seastone, et al. "Differences in Genomic Patterns and Clinical Outcomes Between African-American and White Patients with Myelodysplastic Syndromes (MDS)." Blood 124, no. 21 (2014): 3274. http://dx.doi.org/10.1182/blood.v124.21.3274.3274.

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Abstract Background: African-American (AA) patients (pts) have a younger age at diagnosis and worse outcomes compared to whites (WTs) across many cancers, including acute myeloid and lymphoblastic leukemias. This difference may be related to disease biology rather than access to medical care or socioeconomic status. The incidence of MDS and age at diagnosis in national cancer registries in AAs is lower than in WTs. Detailed biological and clinical characteristics and outcome of AA pts with MDS compared to WTs have not been defined. Methods: We collected mutational and clinical data on MDS pts

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Bekadja, Mohamed-Amine, Mohamed Bradai, Hocine Ait Ali, et al. "Epidemiology and Management of Immune Thrombocytopenia in Adult Patients in Algeria: A Non-Interventional, Longitudinal, Nationwide Estimation Study." Blood 136, Supplement 1 (2020): 3–4. http://dx.doi.org/10.1182/blood-2020-139569.

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Background: Immune thrombocytopenia (ITP), is an acquired immune mediated disease characterized by a platelet count of &lt;50×103/mm3, accelerated destruction of platelets from peripheral circulation, and impaired platelet production. Diagnosis is based on exclusion of other causes of thrombocytopenia. Treatment goal is to ensure sufficient platelet count to prevent bleeding. ITP occurs mainly in women, either at the onset of puberty, or in their 3rd/4th decade, with higher mortality in older patients. To date, no accurate epidemiological data on ITP is available for Algeria. This study as

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Bond, David A., Jeffrey M. Switchenko, Kami J. Maddocks, et al. "Outcomes Following Early Relapse in Patients with Mantle Cell Lymphoma." Blood 134, Supplement_1 (2019): 753. http://dx.doi.org/10.1182/blood-2019-128415.

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Background: Early progression of disease (POD) in patients (pts) with mantle cell lymphoma (MCL) following intensive frontline treatment has been associated with inferior survival (Dietrich et al Ann Oncol 2014 and Visco et al Br J Haematol 2019), but the optimal time point to define early POD and the predictive significance of early POD following less intensive frontline treatment is not well established. We compare outcomes after all frontline treatments in a large MCL cohort categorized by time to progression and describe outcomes by class of second line treatment for pts with primary refra

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Dimopoulos, Meletios Athanasios, Mohamad Hussein, Arlene S. Swern, and Donna M. Weber. "Long-Term Outcomes and Safety of Continuous Lenalidomide Plus Dexamethasone (Len+Dex) Treatment in Patients (Pts) with Relapsed or Refractory Multiple Myeloma (RRMM)." Blood 118, no. 21 (2011): 2929. http://dx.doi.org/10.1182/blood.v118.21.2929.2929.

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Abstract Abstract 2929 Background: Two pivotal phase 3 trials (MM-009 and MM-010) randomized 704 pts to assess Len+Dex vs placebo plus dexamethasone (Dex) in RRMM. The results demonstrated the significant overall survival (OS) benefit of Len+Dex vs Dex (38.0 vs 31.6 mos; p =.045) despite crossover of 48% of Dex pts to the Len+Dex arm at unblinding or progression (Dimopoulos MA et al. Leukemia 2009;23 :2147-52). This is an analysis of the long-term outcomes and safety of continuous Len+Dex treatment. Methods: This retrospective analysis pooled pts treated with Len+Dex in MM-009 and MM-010, with

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Herrick, J., A. Greene, W. Schoolcraft, and R. Krisher. "95 ROLE OF POLYAMINES IN BOVINE PRE-IMPLANTATION DEVELOPMENT." Reproduction, Fertility and Development 28, no. 2 (2016): 177. http://dx.doi.org/10.1071/rdv28n2ab95.

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Polyamines are involved in trophectoderm attachment and outgrowth, but little is known about their role in earlier stages of development. The objective of this study was to evaluate the effects of an inhibitor of polyamine synthesis (difluoromethylornithine, DFMO) on development (blastocyst formation and hatching) and cell allocation to the trophectoderm (TE, CDX2-positive) and inner cell mass (ICM, SOX2-positive) in the bovine embryo. Cumulus-oocyte complexes (COCs) were recovered from slaughterhouse ovaries and matured for 24 h in a defined maturation medium (5.0 mM glucose, 0.6 mM cysteine,

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Burmester, G. R., K. Winthrop, R. Blanco, et al. "AB0522 SAFETY PROFILE OF UPADACITINIB UP TO 3 YEARS IN PATIENTS WITH PSORIATIC ARTHRITIS: AN INTEGRATED ANALYSIS FROM THE PHASE 3 PROGRAM." Annals of the Rheumatic Diseases 80, Suppl 1 (2021): 1287–88. http://dx.doi.org/10.1136/annrheumdis-2021-eular.395.

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Background:The efficacy and safety of upadacitinib (UPA), an oral Janus kinase inhibitor, in patients (pts) with active psoriatic arthritis (PsA) were demonstrated through 24 weeks in the phase 3 SELECT-PsA 1 and SELECT-PsA 2 placebo-controlled clinical trials.1,2Objectives:To describe the long-term integrated safety profile of UPA relative to adalimumab (ADA) in pts with PsA treated in the SELECT program.Methods:The SELECT-PsA program enrolled pts with prior inadequate response or intolerance to ≥1 non-biologic DMARD (SELECT-PsA 1) or ≥1 biologic DMARD (SELECT-PsA 2). Both trials include UPA

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Thrailkill, Kathryn M., Robert Clay Bunn, Philip Ray, and John Leslie Fowlkes. "Low Phosphate Diet Exacerbates Hypercalciuria in the Jimbee Mouse Model of SGLT2 Loss-of Function." Journal of the Endocrine Society 5, Supplement_1 (2021): A236. http://dx.doi.org/10.1210/jendso/bvab048.480.

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Abstract Selective sodium-dependent glucose co-transporter 2 inhibitors (SGLT2is) are a class of anti-hyperglycemic drugs that lower blood glucose in an insulin-independent manner by inhibiting renal glucose reabsorption and promoting glucosuria. In persons with chronic kidney disease, a potential therapeutic target group for such SGLT2i treatment, dietary phosphate restriction is a mainstay of treatment for metabolic bone disease. We investigated the impact of a low phosphate (LP) diet on the physiology of Jimbee mice which, via deletion in exon 10 of the sglt2 gene, provide a model of SGLT2

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Karimi, Yasmin H., Michael Roost Clausen, David John Lewis, et al. "Efficacy and Safety of Epcoritamab Monotherapy in Patients with Relapsed or Refractory LBCL Not Previously Exposed to CAR T: Subanalysis of the Epcore NHL-1 Trial." Blood 144, Supplement 1 (2024): 1737. https://doi.org/10.1182/blood-2024-199225.

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Introduction: Although chimeric antigen receptor T-cell therapies (CAR T) are approved in the relapsed or refractory (R/R) large B-cell lymphoma (LBCL) setting, their usage may be limited by patient (pt) eligibility/fitness, accessibility, and/or manufacturing timelines and consistency. Epcoritamab, a subcutaneous (SC) CD3xCD20 T-cell-engaging bispecific antibody available off the shelf, has led to deep, durable responses with manageable toxicity in pts with R/R LBCL in the pivotal phase 2 EPCORE® NHL-1 trial (NCT03625037), and is approved for the treatment of adults with different types of R/

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Ramirez, Pablo A., Michael P. Rettig, Matthew Holt, and John F. DiPersio. "M2-10B4 Mesenchymal Stromal Cells Confer an In Vitro Protective Effect of Murine mCGPR/+ Acute Promyelocytic Leukemic Cells Against Chemotherapy." Blood 110, no. 11 (2007): 2844. http://dx.doi.org/10.1182/blood.v110.11.2844.2844.

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Abstract Background: The mechanisms by which AML cells and other hematologic malignancies interact with the BM microenvironment to provide a chemoprotective effect remain largely unknown. Our hypothesis is that resistance and relapse of AML may be related to altered AML-BM niche interactions, and that interruption of these interactions might enhance chemosensitivity thus overcoming chemotherapy resistance. In the current studies we have generated an in vitro model of chemotherapy protection mediated by a bone marrow (BM) stromal cell line and attempted to determine soluble and cell associated

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Marconi, Giovanni, Roberta di Nicola, Chiara Sartor, et al. "AML-CM Score Predicts Prognosis in Hemato-Geriatric Patients with New-Onset Acute Myeloid Leukemia (AML) Who Receive Hypomethylating Agents (HMA)." Blood 134, Supplement_1 (2019): 2617. http://dx.doi.org/10.1182/blood-2019-130630.

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Background Although much efforts have been made to precisely define fitness of AML patients, in patients who are not candidate to chemotherapy, there is no prognostic model and the respective weight of AML biology and patient fitness are not well established. Here we test AML-CM score (Sorror, JAMA 2018), that is validated in fit population, in a set of old AML patients who received HMAs. Methods We retrospectively collected data of consecutive patients who received HMAs in our institution from 1st Jan 2008 with an age > 65 years at AML diagnosis. AML-CM score was applied to all the patient

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Iftikhar, Ahmad, Muhammad Ashar Ali, Anum Javaid, et al. "Efficacy and Safety Profile of Ixazomib Based Regimens in Relapsed/Refractory Multiple Myeloma: A Meta-Analysis of Clinical Trials." Blood 136, Supplement 1 (2020): 20–21. http://dx.doi.org/10.1182/blood-2020-141984.

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Background: Multiple myeloma (MM) is an incurable disease, and clinical trials with newer agents have shown improved patient outcomes. There is a need for effective and tolerable treatment for patients with relapsed/refractory MM (RRMM). Proteasome inhibitors (bortezomib, carfilzomib, ixazomib) remain an integral part of regimens used in RRMM or newly diagnosed (ND) MM. This meta-analysis aims to assess the efficacy and safety of ixazomib (Ixa) based regimens in RRMM. Methods: A comprehensive literature search was performed on PubMed, Cochrane, Embase, Web of Science, and clinicaltrials.gov. W

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Guzmán Duxtan, Aldo Javier. "EFECTOS EN LA PRODUCCIÓN CIENTÍFICA Y AVANCES EN LOS PROYECTOS DE INVESTIGACIÓN EN EL PERÚ EN ÉPOCAS DE PANDEMIA." Revista de la Sociedad Química del Perú 86, no. 4 (2021): 339–41. http://dx.doi.org/10.37761/rsqp.v86i4.306.

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según estimaciones de organismos internacionales como la CEPAL, el Banco Mundial y la OMS. La pandemia sigue generando enormes retos y dificultades, en el Perú y en el mundo, particularmente para América Latina y el Caribe (ALC) a pesar de que varios países siguen tomando medidas y restringiendo algunas actividades para evitar la propagación del virus, los casos siguen aumentando. El COVID-19 sigue generando una alta demanda en diversos suministros médicos, descontrol en los sistemas nacionales de salud pública, devela las carencias de acceder a una atención médica digna, ALC sigue enfrentando

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Wagner, Adriana, María del Luján González Tornaría, Lisiane Alvim Saraiva Junges, and Esthella Hernandéz. "Los docentes frente a las demandas de las familias: aproximando contextos (Teachers face the demands of families: approaching contexts)." Revista Eletrônica de Educação 13, no. 2 (2019): 600. http://dx.doi.org/10.14244/198271992543.

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The role of Teachers has been transformed in recent years due to the increasingly complex educational demands and responsibilities that come from the students’ families. The aim of the present study was to investigate how Elementary School Teachers in Brazil and Uruguay perceive and evaluate the demands they receive from families, and how prepared they think they are to face this reality. A qualitative, exploratory and transcultural method was used, based on the technique of Focal Groups, with one group being conducted in Brazil (10 participants) and anther one in Uruguay (9 participants). In

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Girod, Pierre-Pascal, Sara Lener, Nikolaus Kögl, et al. "Health-related quality of life 2 years after pedicle subtraction osteotomy for sagittal imbalance: a single-center experience of 65 patients." Acta Neurochirurgica, September 16, 2023. http://dx.doi.org/10.1007/s00701-023-05787-0.

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Abstract Purpose Pedicle subtraction osteotomy (PSO) as an invasive procedure with high reoperation and complication rates in an often elderly population has often been questioned. The purpose of our study was to evaluate the impact of PSO for sagittal imbalance (SI) on patient-reported outcomes including self-reported satisfaction and health-related quality of life 2 years postoperatively. Methods Consecutive patients who underwent correction of their spinal deformity by thoracolumbar PSO were assessed using self-reporting questionnaires 2 years postoperatively. Outcome was measured by visual

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Vieira, Jose Gilberto, Guilherme Okai, Cláudia Ferrer, and Karina Cardozo. "MON-LB74 The Problem of Measuring 1,25(OH)2 Vitamin D in Patients With High Levels of 25(OH) Vitamin D." Journal of the Endocrine Society 4, Supplement_1 (2020). http://dx.doi.org/10.1210/jendso/bvaa046.2050.

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Abstract Recently, the use of Vitamin D in high doses for treatment of several conditions, mainly autoimmune in nature, has been advocated with dubious results. Hypercalcemia is an important side effect of this intervention. Here we describe our findings in samples that presented 25(OH)D in excess of 150 ng/mL (375 nmol/L) and had 1,25(OH)2D also measured. Material and Methods: we used serum samples from our diagnostic routine, received for measurement of 25(OH)D and 1,25(OH)2D according to medical requisition. A first group (group A) included 213 samples collected up to November 2018, used Di

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Cuong, Vu Van, and Dinh The Hung. "Postoperative Stroke after Anterior Cervical Discectomy and Fusion: A Clinical Case Report." VNU Journal of Science: Medical and Pharmaceutical Sciences 37, no. 3 (2021). http://dx.doi.org/10.25073/2588-1132/vnumps.4309.

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Anterior cervical discectomy and fusion (ACDF) spine surgery has been performed extensively for the treatment of degenerative spine diseases with relatively low rates of complications. The reported incidence of postoperative cerebrovascular events associated with ACDF is only 0.13%, representing 1.51% of all complications. However, this complication is often highly disastrous and can lead to paralysis, and even death. In this study, a 42year-old male underwent anterior cervical discectomy and fusion (ACDF) at C34 and C45 levels through a right-sided approach. Three hours after the surgery, the

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Thomas, Craig, Ruth N. Kingshott, Kirsty M. Allott, et al. "Collagen peptide supplementation before bedtime reduces sleep fragmentation and improves cognitive function in physically active males with sleep complaints." European Journal of Nutrition, October 24, 2023. http://dx.doi.org/10.1007/s00394-023-03267-w.

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Abstract Purpose The primary aim of this study was to examine whether a glycine-rich collagen peptides (CP) supplement could enhance sleep quality in physically active men with self-reported sleep complaints. Methods In a randomized, crossover design, 13 athletic males (age: 24 ± 4 years; training volume; 7 ± 3 h·wk1) with sleep complaints (Athens Insomnia Scale, 9 ± 2) consumed CP (15 g·day1) or a placebo control (CON) 1 h before bedtime for 7 nights. Sleep quality was measured with subjective sleep diaries and actigraphy for 7 nights; polysomnographic sleep and core temperature were recorded

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