Academic literature on the topic '159. 953 – 057. 876 (043.2)'

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Journal articles on the topic "159. 953 – 057. 876 (043.2)"

1

Marincowitz, Carl, Omar Bouamra, Tim Coates, et al. "1427 The effect of the COVID-19 pandemic on major trauma presentations and patient outcomes in English hospitals." Emergency Medicine Journal 39, no. 12 (2022): A960.2—A964. http://dx.doi.org/10.1136/emermed-2022-rcem2.2.

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Aims, Objectives and BackgroundThere is evidence that COVID-19 ‘lockdowns’ may have contributed to increased non-accidental injury, domestic violence and self-harm related to deteriorating mental health. Internationally, there is also evidence that the diversion of health care resources may led to worse outcomes for patients presenting with major trauma. There has been no previous national evaluation of ‘lockdown’ measures impact on the characteristics, treatment pathways and outcomes of trauma patients in EnglandWe aimed to assess the impact of successive lockdowns on the volume, demographics
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Sawattep, Jeeranut, Thad A. Howard, Noppawan P. Morales, et al. "Single Nucleotide Polymorphism (SNP) Discovery within the UGT1A Gene Complex: Allelic Frequencies and Ethnic Differences." Blood 104, no. 11 (2004): 3780. http://dx.doi.org/10.1182/blood.v104.11.3780.3780.

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Abstract The UDP-glycosyltransferase (UGT1A) gene complex plays an important role in the hepatic metabolism of many chemicals, toxins, and drugs including bilirubin and acetaminophen. In this large gene complex that spans over 200kb, there are at least 13 different coding regions that can serve as exon 1, followed by a common sequence that contains exons 2–5. These variable exon 1 sequences confer different chemical specificities for binding compounds, while exons 2–5 provide glycosyltransferase function (glucuronidation) that enhances water solubility and excretion. Mutations and polymorphism
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Dörner, T., Y. Tanaka, M. Mosca, et al. "POS0714 POOLED SAFETY ANALYSIS OF BARICITINIB IN PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS: RESULTS FROM THREE RANDOMISED, DOUBLE-BLIND, PLACEBO-CONTROLLED, CLINICAL TRIALS." Annals of the Rheumatic Diseases 81, Suppl 1 (2022): 639.1–639. http://dx.doi.org/10.1136/annrheumdis-2022-eular.2375.

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BackgroundBaricitinib (BARI), an oral selective inhibitor of Janus kinase 1 and 2 approved for the treatment of rheumatoid arthritis and atopic dermatitis, has been evaluated in clinical studies in patients with systemic lupus erythematosus (SLE).ObjectivesTo assess the safety profile of BARI in patients with SLE.MethodsPatients with SLE receiving stable background therapy were randomised 1:1:1 to BARI 2-mg, 4-mg, or placebo (PBO) once daily in one 24-week, phase 2 (NCT02708095) and two 52-week, phase 3, PBO controlled studies (NCT03616912 and NCT03616964).ResultsA total of 1,849 patients were
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Taylor, P. C., C. Charles-Schoeman, M. Alani, et al. "POS0660 CONCOMITANT USE OF STATINS IN FILGOTINIB-TREATED PATIENTS WITH RHEUMATOID ARTHRITIS." Annals of the Rheumatic Diseases 80, Suppl 1 (2021): 572–73. http://dx.doi.org/10.1136/annrheumdis-2021-eular.933.

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Background:The Janus kinase-1 preferential inhibitor filgotinib (FIL) improved rheumatoid arthritis (RA) signs and symptoms in phase (P)3 trials.1–3 RA elevates cardiovascular disease risk; statins are used to reduce risk.Objectives:To assess safety of statin and filgotinib coadministration across the clinical program.Methods:Patients (pts) meeting 2010 ACR/EULAR RA criteria in P2 DARWIN 1–2 (D1–2; NCT01888874, NCT01894516), P3 FINCH 1–3 (F1–3; NCT02889796, NCT02873936, NCT02886728), and long-term extensions DARWIN 3 and FINCH 4 (D3, F4; NCT02065700, NCT03025308) receiving FIL 100 mg (FIL100)
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Bauman, Glenn, Mohammed Rashid, Deanna L. Langer, et al. "A prospective provincial registry of PSMA PET CT for recurrent prostate cancer (PREP): Results for 4135 men." Journal of Clinical Oncology 43, no. 5_suppl (2025): 35. https://doi.org/10.1200/jco.2025.43.5_suppl.35.

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35 Background: PREP was initiated in Ontario to provide access and characterize performance of PSMA PET CT among men with recurrent prostate cancer after primary definitive treatment (RP or RT). Methods: Between 03/18 and 09/22, 4135 men were accrued. Men were enrolled and imaged with 18F-DCFPyL at 1 of 6 participating sites within 1 of 6 clinical cohorts. Standardized reports delineated sites of recurrence and post PET management changes. Linkage to provincial databases allowed estimation of overall survival and utilization of salvage radiotherapy after PET. Results: Median follow-up was 1.8
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Hanzis, Christina, Zachary Hunter, Robert Manning, et al. "Associated Malignancies Among Patients and Kin with Waldenstrom's Macroglobulinemia." Blood 116, no. 21 (2010): 4159. http://dx.doi.org/10.1182/blood.v116.21.4159.4159.

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Abstract Abstract 4159 Waldenstrom's macroglobulinemia (WM) is a B-cell malignancy characterized as an IgM secreting lymphoplasmacytic lymphoma. Familial predisposition is common in WM. Studies to date by us and others have revealed three identifiable clinical subtypes for WM predisposition: * Sporadic; proband has WM, but there is an absence of WM or other B-cell disorders in other family members; * Familial, Mixed B-cell Disorders Subtype; proband has WM, and various B-cell disorders are manifested by other family members. * Familial, WM Only Subtype; proband has WM, and only WM is present i
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7

Kolarek Karakaš, Mirjana. "Djece je sve manje ali su potrebe sve veće." Paediatria Croatica 69, Suppl 1 (2025): 41–43. https://doi.org/10.13112/pc.1007.

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Evidentno je da je demografski trend Republike Hrvatske u silaznoj putanji kao i u većini Europskih zemalja. Jedan od razloga je smanjenje broja žena u fertilnoj dobi jer žene sve kasnije rađaju zbog svojevrsnih životnih planova i osobnih prioriteta. Prosječna dob rađanja u Republici Hrvatskoj je u dobi od 31-34 godina. Jedna žena u prosjeku rodi 1,5 djece. Da bi se stanovništvo obnavljalo taj broj bi trebao biti 2,1 djeteta. Iseljavanje mladih obitelji u prosječnoj dobi od 20-40 godina dodatno doprinosi sveukupno manjem broju djece. Svake godine sve se manje djece rađa, pa je od 2013. godine
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8

Du, Mengxi, and Fang Fang Zhang. "Dietary Supplement Use Among Adult Cancer Survivors in the United States." FASEB Journal 31, S1 (2017). http://dx.doi.org/10.1096/fasebj.31.1_supplement.168.6.

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BackgroundMany cancer patients initiated supplement use after cancer diagnosis and yet the effect of supplement use on survival has not been established. The trend of and factors associated with dietary supplement use in cancer survivors warrant further investigation.MethodsWe examined the trend of dietary supplemental use in 1,902 adult cancer survivors who participated in the National Health and Nutrition Examination Survey (NHANES) from 1999 to 2012, and compared the frequency of supplement use in cancer survivors to that of 3,804 individuals with no history of cancer who were matched to th
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9

Lee, Ju-Hao, Ni-Chung Lee, and Yi-Ching Tung. "SUN-033 A Rare Case: Bone Pain and Continued Linear Growth in a Young Adult Male Due to Aromatase Deficiency." Journal of the Endocrine Society 4, Supplement_1 (2020). http://dx.doi.org/10.1210/jendso/bvaa046.212.

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Abstract Introduction: Aromatase, the product of CYP19A1, catalyzes the conversion of androgens to estrogens. 46, XX infants with aromatase deficiency, due to androgen excess, present with ambiguous genitalia at birth. In 46, XY individuals, however, the subtle phenotypic features make the diagnosis even more difficult. Less than 15 male cases were reported in the literature and we present the first case of aromatase deficiency diagnosed in Taiwan. Clinical Case: A 23-year-old man, Burman overseas student of Chinese descent, presented to an orthopedist with a two-year history of left ankle pai
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Gazi, Md. Shakhawat Hossain, Shahinur Rahman Md., and Das amir. "A Structural Equation Modeling (SEM) Approach to Explore the Association between Corporate Social Responsibility and Financial Performance: A Single Mediating Mechanism." August 27, 2019. https://doi.org/10.5281/zenodo.3378207.

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<strong><em>Abstrac</em></strong><em>t</em>: <em>The past couple of decades have seen a growing interest in Corporate Social Responsibility (CSR) research in both business and academia. It has been observed that a substantial number of studies on CSR and Financial Performance (FINP) have focused almost entirely on large firms. As pointed out earlier, the bulk number of studies on the link between CSR-firm performances is from developed countries. Thus, a limited number of studies have been conducted in developing countries and more especially in Bangladesh. We cannot generalize the findings fr
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