Log in

Relevant bibliographies by topics / 177Lu / Dissertations / Theses

To see the other types of publications on this topic, follow the link: 177Lu.

Dissertations / Theses on the topic '177Lu'

Author: Grafiati

Published: 4 June 2021

Last updated: 26 July 2025

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the top 40 dissertations / theses for your research on the topic '177Lu.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Browse dissertations / theses on a wide variety of disciplines and organise your bibliography correctly.

1

Sandström, Mattias. "Dosimetry of Radionuclide Therapy with 177Lu-octreotate." Doctoral thesis, Uppsala universitet, Avdelningen för sjukhusfysik, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-158973.

Full text

Abstract:

In radionuclide therapy it is still common to administer standard activities or to scale administered activity with blunt parameters such as body weight or surface area. This is not ideal because, due to considerable variation in kinetics, large safety margins have to be applied to avoid radiation damage to healthy organs, which causes under-treatment of many patients. To base the administered activity on individual dosimetry, as in other therapy modalities using ionizing radiation, will essentially solve this problem. However, dosimetry in radionuclide therapy is resource-demanding and debili

APA, Harvard, Vancouver, ISO, and other styles

2

Gaudin, Émilie Odette. "Imagerie TEM/TDM quantitative du 99mTc- et du 177Lu." Master's thesis, Université Laval, 2015. http://hdl.handle.net/20.500.11794/26094.

Full text

Abstract:

Grâce à l’implémentation d’algorithmes de reconstruction 3D dans les systèmes d’imagerie TEM/TDM, une étude quantitative à partir des images reconstruites est possible. La quantification d’images TEM/TDM est nécessaire afin de permettre une étude dosimétrique 3D des patients atteints de tumeurs neuroendocrines traités au 177Lu-octréotate. Cependant, afin de permettre une quantification précise des images obtenues, plusieurs paramètres du système doivent être déterminés afin d’appliquer les corrections nécessaires. Dans le cadre de cette étude, l’appareil TEM/TDM utilisé est tout d’abord calibr

APA, Harvard, Vancouver, ISO, and other styles

3

Silva, Ana Claudia Machado. "Cinética e dosimetria do [177Lu-DOTA0, Tyr3]octreotato em pacientes com tumores carcinoides." Universidade de São Paulo, 2014. http://www.teses.usp.br/teses/disponiveis/85/85131/tde-29102014-130657/.

Full text

Abstract:

Tumores carcinoides (neoplasias bem diferenciadas) são tumores neuroendócrinos que podem surgir em diferentes locais anatômicos. Na população a prevalência dos tumores carcinoides é de aproximadamente 10 casos para um milhão de habitantes e sua incidência é maior na quinta e sexta década de vida. Este trabalho propõe um modelo cinético baseado na teoria da análise compartimental em humanos com tumores carcinoides que se submeterão ao tratamento com o radiofármaco [177Lu-DOTA0,Tyr3]Octreotato. Imagens cintilográficas dinâmicas planares, obtidas imediatamente à injeção de 370 MBq (10 mCi) do rad

APA, Harvard, Vancouver, ISO, and other styles

4

Filho, José de Souza Caldeira. "Síntese, análise, purificação e biodistribuição em modelo animal do Radiofármaco 177Lu3+-dotatato para uso diagnóstico e terapêutico em tumores neuroendócrinos." Universidade de São Paulo, 2009. http://www.teses.usp.br/teses/disponiveis/85/85131/tde-02062009-160531/.

Full text

Abstract:

Este trabalho teve por objetivo propor uma racionalização da síntese, da análise e da purificação do radiofármaco 177Lu3+-DOTATATO para uso diagnóstico e terapêutico em tumores neuroendócrinos, bem como avaliar a biodistribuição deste radiofármaco em modelo animal. A reação de complexação para a síntese do radiofármaco foi realizada em tampão acetato de amônio 0,5 M, pH 7,0, à 95 oC, com tempo de reação de 30 minutos. Obteve-se pureza radioquímica > 95%, de acordo com a análise por cromatografia em ITLC-SG, utilizando-se como fase móvel, tampão citrato de sódio 0,1 M, pH 5,0. A razão molar-lim

APA, Harvard, Vancouver, ISO, and other styles

5

Garske-Román, Ulrike. "177Lu-DOTA-octreotate Radionuclide Therapy of Neuroendocrine Tumours : Dosimetry-Based Therapy Planning and Outcome." Doctoral thesis, Uppsala universitet, Institutionen för medicinska vetenskaper, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-183417.

Full text

Abstract:

Peptide receptor radionuclide therapy for the internal radiation of neuroendocrine tumours expressing somatostatin receptors has made great advances and offers promising results. 177Lu-DOTA-octreotate is one of the most widely used radiopeptides, but kidneys and bone marrow are organs at risk. Methods of measuring radiation doses to at-risk organs and tumours (dosimetry) on an individual patient basis have been regarded as impracticable and a maximum of 4 treatment cycles has widely been accepted as the treatment standard instead. The first aim of this thesis was to establish a clinically feas

APA, Harvard, Vancouver, ISO, and other styles

6

Vanezi, Maria [Verfasser]. "Fernmetastasierte neuroendokrine Tumoren des Pankreas: Ansprechen auf Radiopeptidtherapie mit 177Lu-DOTA-Octreotat / Maria Vanezi." Bonn : Universitäts- und Landesbibliothek Bonn, 2020. http://d-nb.info/1218301716/34.

Full text

APA, Harvard, Vancouver, ISO, and other styles

7

Reinhardt, Svenja [Verfasser], and Andrei [Akademischer Betreuer] Todica. "Nebenwirkungen und Ansprechen nach einer Radioligandentherapie mit 177Lu-DKFZ-PSMA-617 / Svenja Reinhardt ; Betreuer: Andrei Todica." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2020. http://d-nb.info/1222909065/34.

Full text

APA, Harvard, Vancouver, ISO, and other styles

8

Nava, Cabrera Miguel Angel. "Cálculo dosimétrico del 177Lu-iPSMA y 225Ac-iPSMA a nivel celular en un modelo de metástasis ósea." Tesis de maestría, Universidad Autónoma del Estado de México, 2020. http://hdl.handle.net/20.500.11799/109770.

Full text

Abstract:

En esta tesis se realizó un modelo de metástasis ósea derivada de células de cáncer de próstata en un modelo murino con el propósito calcular la dosis absorbida en el núcleo de las células de cáncer de próstata considerando la biocinética del 177Lu-iPSMA y el 225Ac-iPSMA en el modelo in vivo de metástasis ósea. Para apoyar este cálculo se obtuvieron las fracciones de energía depositadas para cada radiofármaco utilizando simulación Monte Carlo<br>Las metástasis óseas derivadas de cáncer de próstata, además de su gran incidencia, generan gran cantidad de sintomatología adversa. El tratamiento m

APA, Harvard, Vancouver, ISO, and other styles

9

CARRILLO, CAZARES ANDRES 732305, and CAZARES ANDRES CARRILLO. "Evaluación teórica-experimental del cambio de temperatura en tejido por efecto fototérmico plasmónico del sistema 177Lu-AuNP-RGD." Tesis de maestría, Universidad Autónoma del Estado de México, 2017. http://hdl.handle.net/20.500.11799/68705.

Full text

Abstract:

The working group of National Laboratory of Research and Development of Radiopharmaceuticals (LANIDER) from ININ has developed radiopharmaceuticals for diagnosis and therapy at last for the last 20 years. Recently it developed a radiopharmaceutical based on gold nanoparticles (AuNPs) functionalized with the peptide sequence Arg-Gly-Asp (RGD). The RGD sequence has shown a high affinity for avB3 integrins over-expressed in various cancer cells. When AuNPs are exposed to electromagnetic radiation as laser light, the surface plasmon resonance (SPR) effect is induced, in which the free electrons ab

APA, Harvard, Vancouver, ISO, and other styles

10

Sánchez, García María de Fátima, and García Blanca Eli Ocampo. "Diseño y optimización del proceso de producción del Radiofármaco 177Lu-DOTA-Nal3-Octreotido para el tratamiento de Tumores Gastroenteropancreáticos." Tesis de Licenciatura, Medicina-Quimica, 2013. http://ri.uaemex.mx/handle/20.500.11799/13886.

Full text

Abstract:

Diseño y optimización del proceso de producción del Radiofármaco 177Lu-DOTA-Nal3-Octreotido para el tratamiento de Tumores Gastroenteropancreáticos, es un trabajo realizado por el autor: Sánchez García, María de Fátima, Ocampo García, Blanca Eli; con fecha de publicación del año 2013 y con apoyo de edición de Medicina-Quimica

APA, Harvard, Vancouver, ISO, and other styles

11

SILVA, JEFFERSON de J. "Radiomarcação de inibidor de PSMA com 177Lu e avaliação biológica do potencial para aplicação no tratamento do câncer de próstata." reponame:Repositório Institucional do IPEN, 2017. http://repositorio.ipen.br:8080/xmlui/handle/123456789/28415.

Full text

Abstract:

Submitted by Pedro Silva Filho (pfsilva@ipen.br) on 2018-01-29T18:09:18Z No. of bitstreams: 0<br>Made available in DSpace on 2018-01-29T18:09:18Z (GMT). No. of bitstreams: 0<br>O câncer de próstata é considerado o segundo mais comum na população masculina em todo o mundo e ocupa a 15ª posição em mortes por câncer, em homens, representando cerca de 6% do total de mortes por câncer no mundo. O antígeno de membrana prostático específico (PSMA) é uma glicoproteína tipo II transmembrânica superexpressa no câncer de próstata, suas metástases e em neovascularizações relacionadas a tumores sólidos, qu

APA, Harvard, Vancouver, ISO, and other styles

12

Ávila, Sánchez Marcela Angélica. "Aplicación de la radiación Cerenkov de 177Lu a sistemas teranósticos dirigidos a los receptores de quimiocina-4 y SR-B1." Tesis de doctorado, UNIVERSIDAD AUTONOMA DEL ESTADO DE MÉXICO, 2021. http://hdl.handle.net/20.500.11799/111957.

Full text

Abstract:

En esta tesis de doctorado se desarrolló y/o preparó dos sistemas teranósticos capaces de detectar receptores CXCR4 o SR-B1 sobreexpresados en las células de cáncer. El sistema basado en la interacción con el receptor CXCR-4 se preparó al radiomarcar al ligando CXCR-4 con 99mTc y/o 177Lu. El segundo sistema se basó en preparar nanopartículas rHDL cargadas con rodamina. El propósito de este sistema nanométrico consiste en liberar a la rodamina en el interior de las células de cáncer, para después; fotoactivar y/o excitar a la rodamina con radiación Cerenkov y de esta manera producir especies re

APA, Harvard, Vancouver, ISO, and other styles

13

Silva, Jefferson de Jesus. "Radiomarcação de inibidor de PSMA com 177Lu e avaliação biológica do potencial para aplicação no tratamento do câncer de próstata." Universidade de São Paulo, 2017. http://www.teses.usp.br/teses/disponiveis/85/85131/tde-07122017-110519/.

Full text

Abstract:

O câncer de próstata é considerado o segundo mais comum na população masculina em todo o mundo e ocupa a 15ª posição em mortes por câncer, em homens, representando cerca de 6% do total de mortes por câncer no mundo. O antígeno de membrana prostático específico (PSMA) é uma glicoproteína tipo II transmembrânica superexpressa no câncer de próstata, suas metástases e em neovascularizações relacionadas a tumores sólidos, que tem estimulado o desenvolvimento de pequenas moléculas inibidoras do receptor de PSMA, que carreguem agentes terapêuticos. Este trabalho pretendeu estudar de forma inédita a m

APA, Harvard, Vancouver, ISO, and other styles

14

Barkhausen, Christoph [Verfasser], Andreas [Akademischer Betreuer] Türler, and Grafenstein Ulrich [Akademischer Betreuer] Boesl-von. "Production of non carrier added (n.c.a.) 177Lu for radiopharmaceutical applications / Christoph Barkhausen. Gutachter: Ulrich Boesl-von Grafenstein. Betreuer: Andreas Türler." München : Universitätsbibliothek der TU München, 2011. http://d-nb.info/1019587458/34.

Full text

APA, Harvard, Vancouver, ISO, and other styles

15

Costa, Gustavo. "IRDose : un outil web de dosimétrie individualisée basé sur la méthode Monte Carlo pour les patients en thérapie avec le 177Lu." Thesis, Toulouse 3, 2019. http://www.theses.fr/2019TOU30027.

Full text

Abstract:

La médecine nucléaire est une spécialité médicale qui utilise un radiopharmaceutique dont l'administration permet généralement de visualiser une fonction, en détectant les émissions gamma (γ) du radio-isotope vectorisé. Lorsque le but de cette pratique est la thérapie (radiothérapie moléculaire), on privilégie des isotopes qui émettent des radiation à courte portée (α, β ou électrons Auger). Les traitements utilisant 177Lu-DOTATATE ont obtenu leur autorisation de mise sur le marché (AMM) sur la base de l'administration de 7,4 GBq par cycle (activité fixe), sans tenir compte de la variabilité d

APA, Harvard, Vancouver, ISO, and other styles

16

Leenhardt, Julien. "Synthèse et études de radiomarquage au 68Ga, 99mTc, 177Lu et 161Tb de nouveaux chélatants dérivés de l'oxine en vue d'application théranostique." Electronic Thesis or Diss., Université Grenoble Alpes, 2024. http://www.theses.fr/2024GRALS009.

Full text

Abstract:

Les applications théranostiques en médecine nucléaire permettraient idéalement de diagnostiquer les cancers et d’effectuer une radiothérapie interne vectorisée avec la même molécule, simplement en permutant le radionucléide utilisé. L’agent théranostique est constitué d’une partie chélatante susceptible de complexer fortement les radionucléides et d’une partie ligand qui permet d’assurer la vectorisation sur une cible tumorale. Aujourd’hui, un des couples de radionucléides le plus prometteur est constitué du Gallium-68 ou [68Ga]Ga3+ (diagnostic, émetteur de particules β+) et du Lutétium-177 ou

APA, Harvard, Vancouver, ISO, and other styles

17

Delker, Andreas [Verfasser], and Guido [Akademischer Betreuer] Böning. "Investigation of models with temporal and spatial interference in image based dosimetry of 177Lu-labelled radioligand therapies / Andreas Delker. Betreuer: Guido Böning." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2016. http://d-nb.info/111150525X/34.

Full text

APA, Harvard, Vancouver, ISO, and other styles

18

Nagel, Johannes [Verfasser]. "Synthese, Radiomarkierung sowie in vitro- und in vivo-Evaluierung verschiedener Chelator-Biomolekül- Systeme mit den Radionukliden 68Ga, 89Zr und 177Lu / Johannes Nagel." Mainz : Universitätsbibliothek Mainz, 2017. http://d-nb.info/1140168274/34.

Full text

APA, Harvard, Vancouver, ISO, and other styles

19

Greifenstein, Lukas Nikolaus [Verfasser]. "Synthesis, radiolabeling and in vitro and in vivo evaluation of different chelator systems with 44Sc, 64Cu, 68Ga and 177Lu / Lukas Nikolaus Greifenstein." Mainz : Universitätsbibliothek Mainz, 2020. http://d-nb.info/1213305519/34.

Full text

APA, Harvard, Vancouver, ISO, and other styles

20

Brosch-Lenz, Julia [Verfasser], and Guido [Akademischer Betreuer] Böning. "Towards personalized internal radionuclide therapies with 90Y SIRT and 177Lu-PSMA: an investigation of 3D image based dosimetry / Julia Brosch-Lenz ; Betreuer: Guido Böning." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2021. http://d-nb.info/1239049323/34.

Full text

APA, Harvard, Vancouver, ISO, and other styles

21

TRUJILLO, NOLASCO ROSA MAYDELID 792262, and NOLASCO ROSA MAYDELID TRUJILLO. "Preparación y caracterización de nanopartículas de ácido poli(láctico-co-glicólico) PLGA modificadas con ácido hialurónico y radiomarcadas con 177Lu para la liberación controlada de metotrexato." Tesis de maestría, Universidad Autónoma del Estado de México, 2018. http://hdl.handle.net/20.500.11799/98756.

Full text

Abstract:

La radiosinoviortesis (RSO) es una técnica utilizada para disminuir la inflamación del tejido sinovial mediante la inyección intraarticular de un radionúclido emisor beta: β- en forma de partículas o coloides. Actualmente el 177Lu ha sido utilizado en radioterapia debido a sus características de desintegración favorables (T1/2 = 6.71 días; βmáx = 0.497 MeV, 78 %; γ = 0.208 MeV, 11 % y un alcance promedio de 2 mm en tejido blando). Las nanopartículas poliméricas a partir de polímeros biocompatibles y biodegradables como el PLGA representan una alternativa a las terapias convencionales contra la

APA, Harvard, Vancouver, ISO, and other styles

22

Sinnes, Jean-Philippe [Verfasser]. "Synthese und radiochemische Evaluierung von Chelatoren für milde Markierungen mit 68Ga, 44Sc und 177Lu sowie in vitro- und in vivo-Evaluierung von deren TOC- und PSMA-Derivaten / Jean-Philippe Sinnes." Mainz : Universitätsbibliothek Mainz, 2018. http://d-nb.info/1167738667/34.

Full text

APA, Harvard, Vancouver, ISO, and other styles

23

Heigl, Veronika Juliane [Verfasser], and Johannes [Akademischer Betreuer] Hirschberger. "iRGD-vermittelte Effizienzsteigerung des therapeutischen Einsatzes von [177Lu-DOTA0,Tyr3]Octreotid bei somatostatinrezeptorpositivem, malignem Gewebe mit neuroendokrinen Eigenschaften unter besonderer Betrachtung der Nierenfunktion in einem Mausmodell / Veronika Juliane Heigl ; Betreuer: Johannes Hirschberger." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2017. http://d-nb.info/1140735780/34.

Full text

APA, Harvard, Vancouver, ISO, and other styles

24

Rudisile, Simon [Verfasser], and Harun [Akademischer Betreuer] Ilhan. "Evaluation der Toxizität, Effektivität und des Überlebens nach einer Salvage Peptid-Rezeptor-Therapie mit 177Lu-DOTA-octreotate bei Patienten mit metastasierten NET unter Berücksichtigung der SPECT basierten Dosimetrie / Simon Rudisile ; Betreuer: Harun Ilhan." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2021. http://d-nb.info/1236543823/34.

Full text

APA, Harvard, Vancouver, ISO, and other styles

25

GONZALEZ, RUIZ ABRAHAM 690575, and RUIZ ABRAHAM GONZALEZ. "Desarrollo de un radiofármaco teranóstico basado en aptámeros anti VEGF y péptidos NLS-RGD conjugado con nanopartículas de Oro y radiomarcado con Lu-177." Tesis de doctorado, Universidad Autonoma del Estado de México, 2019. http://hdl.handle.net/20.500.11799/105316.

Full text

Abstract:

Cancer is one of the leading causes of death worldwide. According to the National Cancer Institute in Mexico every year there are 128,000 new cases of cancer. The process of angiogenesis in a tumor is a critical process during the development, growth and metastasis, without the necessary neovasculature to acquire nutrients the tumor cannot grow beyond 1-2 mm. During the complex process of angiogenesis, endothelial growth factors that promote the development of new neovasculature are released by the tumor cells. Within the main proangiogenic factors are dominant the endothelial growth factor VE

APA, Harvard, Vancouver, ISO, and other styles

26

Morino, Précillia. "L'enregistrement Eoarchéen des systèmes 146,147Sm-142,143Nd et 176Lu-176Hf : implications pour les mécanismes de différenciation et l'évolution géodynamique de la Terre Hadéenne." Thesis, Université de Lorraine, 2017. http://www.theses.fr/2017LORR0213/document.

Full text

Abstract:

La naissance de la Lune, il y a environ 4.35-4.55 Ga, fut le résultat d'une collision majeure entre la proto-Terre et un embryon planétaire de la taille de Mars. L'énergie cinétique libérée lors de cet impact "géant" a sans doute été suffisante pour engendrer la fusion totale du manteau terrestre sur une profondeur de plusieurs milliers de kilomètres. La première croûte et réservoirs mantelliques différenciés furent ainsi produits par cristallisation de cet océan magmatique, avant d'être en grande partie réhomogénéisés par le recyclage crustal et le mélange convectif. Ce projet vise à apporter

APA, Harvard, Vancouver, ISO, and other styles

27

Valenta, Stanislav. "Fotonové silové funkce v jádře 177Lu z měření dvoukrokových gamma kaskád." Master's thesis, 2010. http://www.nusl.cz/ntk/nusl-297504.

Full text

Abstract:

The subject of the study made in this work are photon strength functions. Many models, both based on theoretical as well as phenomenological approaches, were proposed for these quantities, describing the gamma decay of the nucleus, during last 50 year. However, the correctness of these models is still questionable and its verification is the subject of intensive experimental and theoretical activity at the present time. The results of the analysis of measurements of the two-step cascades following thermal neutron capture on the 176Lu nucleus are compared with the outputs of the Monte Carlo sim

APA, Harvard, Vancouver, ISO, and other styles

28

Silva, Diogo João Duarte da. "Safety and kinetic variation profile of 177Lu-DOTA-TATE uptake in Neuroendocrine Tumors." Master's thesis, 2017. http://hdl.handle.net/10316/82509.

Full text

Abstract:

Trabalho de Projeto do Mestrado Integrado em Medicina apresentado à Faculdade de Medicina<br>Introdução: Os tumores neuroendócrinos constituem um tipo raro de neoplasias caracterizadas pelo seu metabolismo endócrino, padrão histológico único e heterogeneidade biológica. Apesar da progressão insidiosa, uma grande percentagem de doentes desenvolve doença metastática irressecável principalmente a nível hepático, ósseo e ganglionar. Nestes casos, a Terapêutica Radiometabólica com 177Lu-[DOTA0,Tyr3]-octreotate(DOTA-TATE) constitui uma opção terapêutica promissora devido à eficácia limitada das atua

APA, Harvard, Vancouver, ISO, and other styles

29

Akinlolu, Olayinka. "Combination 111In and 177Lu –Dotatoc and Vaccinia Virus Oncolytic Therapy for SSTR2-positive Tumors." Thesis, 2009. http://hdl.handle.net/1807/18131.

Full text

Abstract:

Radiolabeled somatostatin analogues based on octreotide have proven useful in the management of somatostatin receptor subtype 2 (sstr2)-positive tumours in clinical trials. The aim was to compare the potency and evaluate the combination of 111In- and 177Lu-DOTATOC with a double-deleted version of vaccinia virus (ddVV), an oncolytic virus for inhibiting the growth of sstr2-expressing human embryonic kidney (HEK-293) cells or MC-38 murine colon cancer cells grown as monolayers or as spheroids. Cytotoxicity studies were carried out using ddVV, 111In-DOTATOC and 177Lu-DOTATOC, individually or in

APA, Harvard, Vancouver, ISO, and other styles

30

Costa, Adriana Sofia Pereira da. "Aquisição e otimização de imagem planar de 177Lu-DOTATATE com simulações SIMIND Monte Carlo." Master's thesis, 2017. https://repositorio-aberto.up.pt/handle/10216/110686.

Full text

APA, Harvard, Vancouver, ISO, and other styles

31

Costa, Adriana Sofia Pereira da. "Aquisição e otimização de imagem planar de 177Lu-DOTATATE com simulações SIMIND Monte Carlo." Dissertação, 2017. https://repositorio-aberto.up.pt/handle/10216/110686.

Full text

APA, Harvard, Vancouver, ISO, and other styles

32

Rodrigues, Cristiana Magalhães Correia. "Comparison of two 177Lu-DOTATATE quantification methods for patient personalized dosimetry in therapy of neuroendocrine tumors." Master's thesis, 2021. http://hdl.handle.net/10451/51816.

Full text

Abstract:

Tese de Mestrado Integrado, Engenharia Biomédica e Biofísica (Radiações em Diagnóstico e Terapia), 2021, Universidade de Lisboa, Faculdade de Ciências<br>Peptide receptor radionuclide therapy (PRRT) with 177Lu-DOTATATE is remarkably effective in the treatment of neuroendocrine tumors (NETs) over-expressing somatostatin receptors. Besides potential renal and/or hematological toxicity, the significant response inter-patient variability requires individual treatment planning. Several methods have been used to quantify tissue absorbed dose. The aim of this study was to compare the dosimetry calcul

APA, Harvard, Vancouver, ISO, and other styles

33

Dvořáková, Zuzana [Verfasser]. "Production and chemical processing of 177Lu for nuclear medicine at the Munich research reactor FRM-II / Zuzana Dvořáková." 2007. http://d-nb.info/986094722/34.

Full text

APA, Harvard, Vancouver, ISO, and other styles

34

Zöckler, Christine Anne [Verfasser]. "Bewertung der lokoregionalen Radioimmuntherapie disseminierter Tumorzellen des diffusen Magenkarzinoms mit tumorspezifischen 177Lu-d9MAk-Konjugaten im Mausmodell / Christine Anne Zöckler." 2006. http://d-nb.info/985441909/34.

Full text

APA, Harvard, Vancouver, ISO, and other styles

35

Petřík, Michal. "Studium stability monoklonální protilátky nimotuzumab modifikované chelátorem DOTA radioaktivně značené luteciem-177 ([177Lu]Lu-hR3(p-SCN-Bn)DOTA)." Master's thesis, 2010. http://www.nusl.cz/ntk/nusl-279146.

Full text

Abstract:

The higher expressivity of the gene for the receptor of epidermal growth factor (EGF) and consequently higher number of receptors (EGFR) on the surface of cells is closely linked with the tumour proliferation of these cells and with poor prognosis for patients. For such reason the EGFR became one of the main objectives in the therapy of tumours. Nimotuzumab (also known as h-R3) is humanized monoclonal antibody which blocks receptor for epidermal growth factor. The object of this thesis was to determinate radiochemical purity of this antibody conjugated with bifunctional chelator DOTA and marke

APA, Harvard, Vancouver, ISO, and other styles

36

Korec, David. "Studium stability monoklonální protilátky nimotuzumab modifikované chelátorem DTPA radioaktivně značené luteciem-177 ([177Lu]Lu-hR3(p-SCN-Bn)DTPA)." Master's thesis, 2010. http://www.nusl.cz/ntk/nusl-279509.

Full text

Abstract:

Stability studies of monoclonal antibody nimotuzumab modified with chelator DTPA radiolabelled with lutetium-177 ([177Lu]Lu-hR3(p-SCN-Bn)DTPA) Diploma thesis David Korec Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department of Biophysics and Physical Chemistry In this work was target to study the stability of monoclonal antibody Nimotuzumab, which was modified with chelator DTPA radiolabelled with radioactive Lutetium-177 ([177Lu] Lu-hR3 (p- SCN-Bn) DTPA). The radiochemical purity of the supplied antibody was 61%. For other uses had to purified. The chelator EDTA adds

APA, Harvard, Vancouver, ISO, and other styles

37

Teixeira, Ana Rita Carvalho. "Clinical dosimetry and pharmacokinetic modelling of radiolabeled Sarabesin 3 with 68Ga and 177Lu: A new approach for prostate cancer theranostics." Master's thesis, 2019. https://hdl.handle.net/10216/125110.

Full text

APA, Harvard, Vancouver, ISO, and other styles

38

Teixeira, Ana Rita Carvalho. "Clinical dosimetry and pharmacokinetic modelling of radiolabeled Sarabesin 3 with 68Ga and 177Lu: A new approach for prostate cancer theranostics." Dissertação, 2019. https://hdl.handle.net/10216/125110.

Full text

APA, Harvard, Vancouver, ISO, and other styles

39

Joshi, Jay. "Understanding the mechanism of 177Lu- PSMA617 radioligand therapy and evaluating its potential role in the treatment of metastatic castrate resistant prostate cancer (mCRPC)." Thesis, 2020. http://hdl.handle.net/1828/12479.

Full text

Abstract:

Prostate cancer is the most common cancer in men and the third leading cause of cancer-related deaths in Canadian men. Despite hormone and radiation therapies, most patients progress to late-stage metastatic castrate-resistant prostate cancer (mCRPC). 177Lu-PSMA617 radioligand therapy (rLT) is a radioactive biochemical substance that targets the human prostate-specific membrane antigen (hPSMA). This rLT has been used in compassionate trials in mCRPC patients and has been demonstrated significant clinical efficacy. However, recent findings suggest that this efficacy is short-lived, and most pat

APA, Harvard, Vancouver, ISO, and other styles

40

PISTONE, DANIELE. "Applications of Monte Carlo simulation in internal dosimetry of radiopharmaceuticals employed in nuclear medicine." Doctoral thesis, 2021. http://hdl.handle.net/11570/3214160.

Full text

Abstract:

Internal dosimetry (ID) is acquiring a fundamental role in nuclear medicine for the planning, optimization and monitoring of radiopharmaceutical therapies and diagnostics. Direct Monte Carlo (MC) simulation of radiation transport, using morphological and functional tomographic imaging as input data to model, respectively, patient’s body and radiopharmaceutical biodistribution, is the gold standard approach for ID. Despite being the most accurate and patient-specific method available, MC ID is not routinely employed in clinics, because of its relevant requirements in terms of computational reso

APA, Harvard, Vancouver, ISO, and other styles

We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!