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Journal articles on the topic '19a'

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Published: 4 June 2021

Last updated: 15 February 2022

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1

Möhrle, H., and J. Mehrens. "Cyclisierungen über Enamin-Zwischenstufen bei Amindehydrierungen/Cyclizations via Enamine Intermediates with Amine Dehydrogenations." Zeitschrift für Naturforschung B 54, no. 2 (1999): 214–24. http://dx.doi.org/10.1515/znb-1999-0210.

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The mercury-edta dehydrogenation of the 4′-aminosubstituted-acetophenones 1, 8a and 9a produced the ring cleavaged derivatives 7 ,11a and 12a, while the piperidine and its derivatives 10a - 10e gave rise to tetracyclic compounds 16a - 16e and to methylenedi-enamines 19a - 19d, the additionally C-1-fragment in 19a - 19d probably coming from mercury edta. With addition of m-nitrobenzaldehyde to the mercury-edta dehydrogenation of substituted phenylpiperidines another route only generated the di-enamines 22.

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2

Kantlehner, Willi, Erwin Haug, Rüdiger Stieglitz, Wolfgang Frey, Ralf Kress, and Jochen Mezger. "Orthoamide, LVIII . Kondensationsreaktionen von CH2-aciden Verbindungen mit Orthoamiden von Carbonsäuren und Alkincarbonsäuren / Orthoamides, LVIII . Condensation Reactions of CH2-Acidic Compounds with Orthoamides of Carboxylic Acids and Alkyne Carboxylic Acids." Zeitschrift für Naturforschung B 57, no. 4 (2002): 399–419. http://dx.doi.org/10.1515/znb-2002-0406.

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The orthoamide derivatives 1s and 2e were prepared from the guanidinium salt 7a and the appropriate carbanions. Cleavage of the orthoamide 2e with benzoyl chloride affords the amidinium salt 10a, which can be transformed into the amidinium salt 10b by an anion exchange reaction. The enamines 11a-i, 12a-c, 13a, b, 14a-c, 15a, b, 16, 17a, b, 18a, b, 19a, b, 20 were prepared by condensation of CH2-acidic compounds with the carboxylic acid orthoamides 2a-j. The orthoamide 2d reacts with 1-nitropropane to give the amidinium salt 27a which is transformed into the salt 27b. From benzyl cyanide and or

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3

Hien, Nguyen Thi, Pham Duc Khue, Kim Tien Thanh, and Nguyen Van Do. "Study of Multiple Photoneutron Reactions on 197Au Induced by 2.5 GeV Bremsstrahlung." Communications in Physics 23, no. 4 (2013): 331. http://dx.doi.org/10.15625/0868-3166/23/4/3146.

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We identified eight radionuclides \(^{196}\)Au, \(^{195}\)Au, \(^{194}\)Au, \(^{193}\)Au, \(^{192}\)Au, \(^{191}\)Au, \(^{190}\)Au, \(^{189}\)Au formed via the multiple photoneutron reactions \(^{197}\)Au\((\gamma ,kn)^{197 - k}\)Au with 2.5 GeV\break bremsstrahlung. The yields of radionuclides that decay by emitting \(\gamma \)-ray were measured using high purity germanium (HPGe) detector coupled to a PC-based multichannel analyzer. In order to improve the accuracy of the experimental results the necessary corrections were made. The obtained results are compared with reference data and the va

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4

Andersen, Heidi Gade, David Kvaskoff, and Curt Wentrup. "Bisiminopropadienes R-N=C=C=C=N-R from Pyridopyrimidines." Australian Journal of Chemistry 65, no. 6 (2012): 686. http://dx.doi.org/10.1071/ch12039.

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Chlorination of the N,N′-di(2-pyridyl)malonamide 13a affords 2-chloro-8-methyl-4-(2-(4-picolinyl)imino-4H-pyrido[1,2-a]pyrimidine 17a. Flash vacuum thermolysis of 17a causes efficient ring opening to the valence-tautomeric ketenimine 18a/19a, elimination of HCl, and formation of the bis(4-methyl-2-pyridyl)iminopropadiene, R-N=C=C=C=N-R 20a.

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5

Zhao, Li-Min, Zhen Guo, Yi-Jie Xue та ін. "Synthesis and Evaluation of 3-Substituted-4-(quinoxalin-6-yl) Pyrazoles as TGF-β Type I Receptor Kinase Inhibitors". Molecules 23, № 12 (2018): 3369. http://dx.doi.org/10.3390/molecules23123369.

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The transforming growth factor-β (TGF-β), in which overexpression has been associated with various diseases, has become an attractive molecular target for the treatment of cancers. Thirty-two quinoxaline-derivatives of 3-substituted-4-(quinoxalin-6-yl) pyrazoles 14a–d, 15a–d, 16a–d, 17a–d, 18a–d, 19a–d, 25a, 25b, 25d, 26a, 26b, 26d, 27b, and 27d were synthesized and evaluated for their activin TGF-β type I receptor kinase and p38α mitogen activated protein (MAP) kinase inhibitory activity in enzymatic assays. Among these compounds, the most active compound 19b inhibited TGF-β type I receptor k

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6

Tomaščiková, Jana, Ján Imrich, Ivan Danihel, Stanislav Böhm, and Pavol Kristian. "Heterocyclization of (Acridin-9-yl)thiosemicarbazides with Dimethyl Acetylenedicarboxylate." Collection of Czechoslovak Chemical Communications 72, no. 3 (2007): 347–62. http://dx.doi.org/10.1135/cccc20070347.

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Two types of (acridin-9-yl)thiosemicarbazides with the acridine moiety in the thiourea part (Acr-NHCS, 10a, 10b) and hydrazine part (Acr-NHNHCS, 12a-12c) were prepared to investigate their reactions with dimethyl acetylenedicarboxylate. Five-membered thiazolidinone derivatives 15a, 15b, 19a-19c were formed; some aspects of corresponding reaction mechanisms are discussed. 1D and 2D 1H and 13C NMR spectroscopy and DFT quantum chemical calculations were used to elucidate the structure of the compounds.

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7

Hassaneen, Hamdi M., Wagnat W. Wardkhan, and Yasmin Sh Mohammed. "A Novel Route to Isoquinoline[2,1-g][1,6]naphthyridine, Pyrazolo[5,1-a] isoquinoline and Pyridazino[4´,5´:3,4]pyrazolo[5,1-a]isoquinoline Derivatives With Evaluation of Antitumor Activities." Zeitschrift für Naturforschung B 68, no. 8 (2013): 895–904. http://dx.doi.org/10.5560/znb.2013-3101.

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(E)-2-Chloro-3-(2-cyanovinyl)-9,10-dimethoxy-4-oxo-6,7-dihydro-4H-pyrido[2,1-a] isoquinoline- 1-carbonitrile (5) was obtained by treatment of the 2-chloro-3-formylpyrido[2,1-a]isoquinoline derivative 3 with 2-(triphenylphosphoranylidene)acetonitrile (4). Treatment of 5 with sodium azide afforded the corresponding azido compound 6 which could be reduced by sodium dithionite to compound 7. A novel isoquinolino[2,1-g][1,6]naphthyridine derivative 11 was obtained by the reaction of phenyl isothiocyanate with the phosphorane compound 8, which was prepared by the reaction of compound 6 with tripheny

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8

Plenzig, Felicitas, Alexey Lyubimtsev, and Michael Hanack. "Synthesis of Acetylene Bridged Germanium Phthalocyanines." Natural Product Communications 7, no. 3 (2012): 1934578X1200700. http://dx.doi.org/10.1177/1934578x1200700319.

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The octaalkyl- or octaalkoxysubstituted phthalocyaninatogermanium dichlorides 10b,d,e and 10a-c were reacted with bisbromomagnesiumacetylene 16 and bisbromomagnesium- p-diethynylbenzene 18, respectively with formation of the corresponding acetylene bridged oligomers 17a-c and 19a-c, respectively.

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9

Sanad, Sherif M. H., Azza M. Abdel-Fattah, Fawzy A. Attaby, and Mohamed A. A. Elneairy. "Synthesis and characterization of novel bis(pyridine-2(1H)-thiones) and their bis(2-methylsulfanylpyridines) incorporating 2,6-dibromophenoxy moiety." Canadian Journal of Chemistry 97, no. 1 (2019): 53–60. http://dx.doi.org/10.1139/cjc-2017-0721.

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The novel 1,4-bis(2,6-dibromo-4-formylphenoxy)butane (3), prepared from 3,5-dibromobenzaldehyde (1), reacted with different hydrazines 4a–4d and active methylene containing compounds 9a–9d to give the corresponding bis(hydrazones) 5a–5d and bis(cinnamonitriles) 11a–11d, respectively. Both bis(2-cyanoacetic acid hydrazide) derivative 5d and bis(thioacrylamide) derivative 11a were taken as synthetic precursors for the synthesis of the target molecules bis(pyridine-2(1H)-thione) derivative 10 and 13a–13c and their bis(2-methylsulfanylpyridine) derivative 14 and 17a–17c. Another synthetic route wa

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10

Zurmühlen, Frank, Wolfgang Rösch, and Manfred Regitz. "Phosphorverbindungen ungewöhnlicher Koordination, 5 [3+2]- sowie [4+2]-Cycloadditionsreaktionen an ein kinetisch stabilisiertes Phosphaalken/ Phosphorus Compounds with Unusual Coordination, 5 [3+2]- as well as [4+2]-Cycloaddition Reactions to a Kinetically Stabilized Phosphaalkene." Zeitschrift für Naturforschung B 40, no. 8 (1985): 1077–86. http://dx.doi.org/10.1515/znb-1985-0816.

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AbstractAliphatic diazo compounds display different reactivity towards the phosphaalkene 9: diazomethane, diazoethane and terf-butyl diazoacetate (10a-c) formally react with Si/P-insertion to give the hitherto unknown phosphaalkenes 12a-c. In contrast, 1-diazo-2.2-dim ethylpropane (10d) and diazotrimethylsilylmethane (10e) lead to the 1.2.4-diazaphospholes 15 and 17, respectively, if the primary products (11d , 14) are treated with sodium hydroxide in tetrahydrofuran. T he reaction of the nitrile oxides 18a-c with 9 yields the 1.2.4-oxazaphospholes 20a-c; the [3+2] cycloadducts 19a-c are assum

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11

Ugwu, David, Uchechukwu Okoro, and Narendra Mishra. "Synthesis, characterization and anthelmintic activity evaluation of pyrimidine derivatives bearing carboxamide and sulphonamide moieties." Journal of the Serbian Chemical Society 83, no. 4 (2018): 401–9. http://dx.doi.org/10.2298/jsc170127109u.

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Pyrimidines, sulphonamides and carboxamides have shown a large number of pharmacological properties against different types of diseases including helminthiasis. Seventeen new pyrimidine derivatives bearing sulphonamide and carboxamide were synthesized and investigated for their in vitro anthelmintic properties. Substituted benzenesulphonyl chlorides 15a?c were treated with various amino acids (16a?h) to obtain benzenesulphonamide derivatives 17a?l. Compounds 17a?f were subsequently treated with benzoyl chloride to obtain the N-benzoylated derivatives 19a?f. Further reactions of compounds 19a?f

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12

Ismail, Mostafa. "Synthesis and cyclization reactions of 2-(6-methylquinolin-4-yl)malononitriles and ethyl 2-cyano-2-(6-methylquinolin-4-yl)acetates." Journal of the Serbian Chemical Society 71, no. 7 (2006): 721–32. http://dx.doi.org/10.2298/jsc0607721i.

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The nucleophilic substitution reactions of 2,4-dichloro-6-methylquinoline (1) and 4-chloro-6-methylquinolin-2(1H)-one (7) with malononitrile and ethyl cyanoacetate are described. The quinolinylmalononitrile 8a and cyanoacetate 8b were utilized to prepare the novel polyfunctionalized benzoquinolinones 10a,b, pyridylquinolinones 11a,b, pyrazolylquinolinones 12a-e isoxazolylquinolinone 13, pyrimidylquinolinones 14a-c, thienoquinolinones 15, 16a,b, and pyridothienoquinolinones 17a,b. The structures of the new compounds were based on analytical and spectral results.

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13

Landskroner-Eiger, Shira, Cong Qiu, Paola Perrotta, et al. "Endothelial miR-17∼92 cluster negatively regulates arteriogenesis via miRNA-19 repression of WNT signaling." Proceedings of the National Academy of Sciences 112, no. 41 (2015): 12812–17. http://dx.doi.org/10.1073/pnas.1507094112.

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The contribution of endothelial-derived miR-17∼92 to ischemia-induced arteriogenesis has not been investigated in an in vivo model. In the present study, we demonstrate a critical role for the endothelial-derived miR-17∼92 cluster in shaping physiological and ischemia-triggered arteriogenesis. Endothelial-specific deletion of miR-17∼92 results in an increase in collateral density limbs and hearts and in ischemic limbs compared with control mice, and consequently improves blood flow recovery. Individual cluster components positively or negatively regulate endothelial cell (EC) functions in vitr

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14

Vettel, Markus, Hans-Jürgen Bräuner, and Willi Kantlehner. "Orthoamide und Iminiumsalze, XCIII. Darstellung und Umsetzungen eines vinylogen Orthoamid-Derivats der Kohlensäure mit CH2-aciden Verbindungena." Zeitschrift für Naturforschung B 73, no. 7 (2018): 457–66. http://dx.doi.org/10.1515/znb-2018-0022.

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AbstractThe preparation of the vinylogue guanidinium salt 10c is described. The reaction of the vinylogue orthocarbonic acid amide derivative 12 with CH2-acidic compounds 14a–s affords the ketene aminals 15a–s. At room temperature the succinimide 19a is deprotonated by 12 to give the vinylogue salt 10e. The bis-ketene aminal 20 is formed in the reaction of 19a with 12 at elevated temperatures. Succinic acid esters 21 do not react cleanly with the orthoamide 12, but mixtures of ketene aminals 23 and bis-ketene aminals 22 are formed. From succinodinitrile (24) and 12 the bis-ketene aminal 25 cou

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15

Rep, Valentina, Martina Piškor, Helena Šimek, et al. "Purine and Purine Isostere Derivatives of Ferrocene: An Evaluation of ADME, Antitumor and Electrochemical Properties." Molecules 25, no. 7 (2020): 1570. http://dx.doi.org/10.3390/molecules25071570.

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Novel purine and purine isosteres containing a ferrocene motif and 4,1-disubstituted (11a−11c, 12a−12c, 13a−13c, 14a−14c, 15a−15c, 16a, 23a−23c, 24a−24c, 25a−25c) and 1,4-disubstituted (34a−34c and 35a−35c) 1,2,3-triazole rings were synthesized. The most potent cytotoxic effect on colorectal adenocarcinoma (SW620) was exerted by the 6-chloro-7-deazapurine 11c (IC50 = 9.07 µM), 6-chloropurine 13a (IC50 = 14.38 µM) and 15b (IC50 = 15.50 µM) ferrocenylalkyl derivatives. The N-9 isomer of 6-chloropurine 13a containing ferrocenylmethylene unit showed a favourable in vitro physicochemical and ADME p

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16

Liu, Zhenying, Irving Nachamkin, Paul H. Edelstein, Ebbing Lautenbach, and Joshua P. Metlay. "Serotype Emergence and Genotype Distribution among Macrolide-Resistant Invasive Streptococcus Pneumoniae Isolates in the Postconjugate Vaccine (PCV-7) Era." Antimicrobial Agents and Chemotherapy 56, no. 2 (2011): 743–50. http://dx.doi.org/10.1128/aac.05122-11.

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ABSTRACTWe conducted population-based surveillance for pneumococcal bacteremia within a 5-county region surrounding Philadelphia from October 2001 through September 2008, the period following introduction of the seven-valent pneumococcal conjugate vaccine. Erythromycin resistance increased from 14.7% in 2001-2002 to 20.3% in 2007-2008, while the resistance rate to penicillin (MIC, ≥2 μg/ml) decreased from 7.2% to 4.2% during the same period. The most predominant serotypes associated with erythromycin resistance in 2007-2008 included 19A (29.7%), 15A (29.2%), 6C (10.1%), 3 (5.6%), and 6A (4.5%)

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17

Domenech, Arnau, Jose M. Tirado-Vélez, Asunción Fenoll, et al. "Fluoroquinolone-Resistant Pneumococci: Dynamics of Serotypes and Clones in Spain in 2012 Compared with Those from 2002 and 2006." Antimicrobial Agents and Chemotherapy 58, no. 4 (2014): 2393–99. http://dx.doi.org/10.1128/aac.02669-13.

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ABSTRACTIn Spain, rates of ciprofloxacin resistance in pneumococci were low during the last decade (2.6% in 2002 and 2.3% in 2006). In 2012, the rate remained at 2.3%, equivalent to 83 of 3,621 isolates. Of the 83 resistant isolates, 15 showed a low level (MIC of 4 to 8 μg/ml) and 68 a high level (MIC of 16 to 128 μg/ml) of ciprofloxacin resistance. Thirteen low-level-resistant isolates had single changes in ParC, one had a single ParE change, and one did not present any mutations. High-level-resistant isolates had GyrA changes plus additional ParC and/or ParE changes: 51, 15, and 2 isolates h

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18

Fuentes-Gutiérrez, Alfredo, Everardo Curiel-Quesada, José Correa-Basurto, Alberto Martínez-Muñoz, and Alicia Reyes-Arellano. "N-Heterocycles Scaffolds as Quorum Sensing Inhibitors. Design, Synthesis, Biological and Docking Studies." International Journal of Molecular Sciences 21, no. 24 (2020): 9512. http://dx.doi.org/10.3390/ijms21249512.

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Quorum sensing is a communication system among bacteria to sense the proper time to express their virulence factors. Quorum sensing inhibition is a therapeutic strategy to block bacterial mechanisms of virulence. The aim of this study was to synthesize and evaluate new bioisosteres of N-acyl homoserine lactones as Quorum sensing inhibitors in Chromobacterium violaceum CV026 by quantifying the specific production of violacein. Five series of compounds with different heterocyclic scaffolds were synthesized in good yields: thiazoles, 16a–c, thiazolines 17a–c, benzimidazoles 18a–c, pyridines 19a–c

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19

Siegemund, Anja, Christine Hartung, Alexander Eilfeld, Joachim Sieler, and Bärbel Schulze. "Facile Synthesis of Novel N-Aryl-4,5,6,7-tetrahydro-benzosultams by Oxyfunctionalisation of Bicyclic Isothiazolium Salts*." Zeitschrift für Naturforschung B 59, no. 4 (2004): 478–85. http://dx.doi.org/10.1515/znb-2004-0416.

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Abstract3-Hydroxy- (17a - j) and 3-alkoxy-4,5,6,7-tetrahydro-benzosultams 18a-m were prepared in good yields by oxidation of the bicyclic isothiazolium salts 10 with magnesium monoperoxyphthalate (MMPP·6H2O) in acetonitrile or corresponding alcohol. A HPLC-API-MS(MS) method was used to monitor the oxidation process of 10 with MMPP. 3-Oxo-4,5,6,7-tetrahydro-benzosultams 19a - c, h, j were also obtained.

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20

Margetic, Davor, Douglas N. Butler, and Ronald N. Warrener. "Photolysis of Fused Cyclobutatriazolines: An Adventitious Route to 3,6-Di(2-pyridyl)pyridazonorbornadiene." Australian Journal of Chemistry 53, no. 12 (2000): 959. http://dx.doi.org/10.1071/ch00129.

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Ultraviolet irradiation of the triazolines (18a,b) formed by the high-pressure addition of benzyl azide to dimethyl 3,6-di(2-pyridyl)-4,5-diazatetracyclo[6.4.1.0 2,3 .0 9,12 ]trideca-3,5,7,10-tetraene-10,12-dicarboxylate (16a) and the related monoester (16b), forms 13–17% of the expected aziridine (19a,b), together with cyclobutane-cleavage products that include the hitherto unknown pyridazinonorbornadiene (2), its di-π-methane rearrangement product (21) and the corresponding triazoles (20a,b). Mechanistic pathways are discussed.

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21

Kim, Ye Kyung, Kyuyol Rhie, Yun Young Choi, Hoan J. Lee, Ki Wook Yun, and Eun Hwa Choi. "2708. Genetic Structure of Streptococcus pneumoniae Isolated from Invasive Disease in Korea, 2014–2016." Open Forum Infectious Diseases 6, Supplement_2 (2019): S952. http://dx.doi.org/10.1093/ofid/ofz360.2385.

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Abstract Background The extended-valency pneumococcal conjugate vaccines (PCVs) were implemented into Korean national immunization program in 2014. This study investigated the change in genetic structures of Streptococcus pneumoniae causing invasive pneumococcal disease (IPD) in Korean children after 10- and 13-valent conjugate vaccine (PCV10 and PCV13, respectively) use. Methods Between January 2014 and December 2016, invasive isolates were collected from 23 hospitals throughout Korea. Cases of IPD were defined by isolating pneumococci from normally sterile sites. Each pneumococcal isolate wa

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22

Taraymovich, Ekaterina S., Andrey B. Korzhenevskii, Yulia V. Mitasova, Roman S. Kumeev, Oscar I. Koifman, and Pavel A. Stuzhin. "Synthesis and spectral study of tetra(2,3-thianaphtheno)-porphyrazine, its tetra-tert-butyl derivative and their Mg(II), Al(III), Ga(III) and In(III) complexes." Journal of Porphyrins and Phthalocyanines 15, no. 01 (2011): 54–65. http://dx.doi.org/10.1142/s1088424611002969.

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Starting from easily available thiophenols (PhSH (1a), 4-tert-butyl-PhSH (1b)) and oxalylchloride we have prepared 2,3-thianaphtenequinones 2a,b which were then successively converted to thianaphthene-2,3-dicarboxylic acids 4a,b their imides 10a,b, diamides 9a,b and finally to thianaphthene-2,3-dicarbonitriles 11a,b — the key precursors for the series of novel porphyrazines bearing four 2,3-annulated thianaphthene moieties. The free-bases 12a,b were obtained by cyclotetramerization of the dinitrile 11a,b in the presence of lithium in n-pentanol, while the reaction with magnesium(II) butoxide i

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23

Morrison, D., G. G. Bennet, and M. G. Bayat. "The Don Field, Blocks 211/13a, 211/14, 211/18a, 211/19a, UK North Sea." Geological Society, London, Memoirs 14, no. 1 (1991): 89–93. http://dx.doi.org/10.1144/gsl.mem.1991.014.01.11.

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AbstractThe Don Oilfield is located towards the western margin of the Viking Graben. It lies within four UKCS Blocks, 211/13a, 211/14, 211/18a, and 211/19a, some 15 km (9 miles) north of the Thistle Field. The field is structurally complex and consists of two discrete accumulations (Don NE and Don SW) which are separated by a WNW-ESE fault. The oil is trapped in sandstones of the Middle Jurassic Brent Group at depths of between 11 000 and 11 500 ft SS. Reservoir quality is variable with the Etive and Ness formations which contain the most productive intervals.The Field is structurally complex

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Milne, A. D., and A. M. Brown. "The Don Field, Blocks 211/13a, 211/14, 211/18a, 211/19a, UK North Sea." Geological Society, London, Memoirs 20, no. 1 (2003): 257–63. http://dx.doi.org/10.1144/gsl.mem.2003.020.01.22.

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abstractCumulative oil production to the end of 2000 from the Don Field was 15.4 MMBBLS, which with an estimated STOIIP of 152 MMBBLS represents a recovery to date of 10%. Don has been producing for over ten years. The field lics 15 km N of the Thistle Field, at the western edge of the Viking Graven in the northern North Sea. The structure of the field is complex, and it comprises several segments, the two larges of which have been developed, Don NE and Don SW. The reservoir sequence is Middle Jurassic Brent Formation. But more deeply buried and of a more distal facies than is typical for othe

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25

Richter, Sandra S., Daniel J. Diekema, Kristopher P. Heilmann, Cassie L. Dohrn, Fathollah Riahi, and Gary V. Doern. "Changes in Pneumococcal Serotypes and Antimicrobial Resistance after Introduction of the 13-Valent Conjugate Vaccine in the United States." Antimicrobial Agents and Chemotherapy 58, no. 11 (2014): 6484–89. http://dx.doi.org/10.1128/aac.03344-14.

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ABSTRACTOngoing surveillance forStreptococcus pneumoniaeis needed to assess the impact of the pneumococcal conjugate vaccine introduced in 2010 (PCV13). Forty-two U.S. centers submittedS. pneumoniaeisolates between 1 October 2012 and 31 March 2013. Susceptibility testing was performed by use of a broth dilution method as recommended by the Clinical and Laboratory Standards Institute. Serotyping was performed by multiplex PCR and the Quellung reaction. Multidrug resistance (MDR) was defined as nonsusceptibility to penicillin (PNSP; MIC ≥ 0.12 μg/ml) combined with resistance to ≥2 non-β-lactam a

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Samatova, E. V., A. E. Druy, G. A. Tsaur, and L. G. Boronina. "SEROTYPING OF STREPTOCOCCUS PNEUMONIAE STRAINS, ISOLATED FROM CHILDREN IN URAL REGION WITH THE USE OF MULTIPLEX PCR." Epidemiology and Infectious Diseases 17, no. 5 (2012): 26–30. http://dx.doi.org/10.17816/eid40701.

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This article presents results of the multiplex PCR investigation of the serotypes distribution of S. pneumoniae strains circulating in Ekaterinburg and the Sverdlovsk region. This study was performed in children with invasive, noninvasive pneumococcal infections and carriers. 118 strains of pneumococci typed out of 129 ones (91.5%) referred to the 15 serotypes: 6A, 6B (20,8%); 23F (13,9%); 19F (11,5%); 8, 9V, 9A, 11F, 11A, 11B, 11C, 11D, 12F, 15A, 33F (11,5%); 3 (10%) 2, 15F, 17F, 22F, 23B (3,9%); 18B, 18C (3.9%), 19A (3,2%); 7F, 19B, 19C, 23A (3,2%); 5,10A (1.6%), 20 (1.6%), 14 (1, 6%); 9L, 9

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El-Sawy, Eslam, Adel Mandour, Khaled Mahmoud, Inas Islam, and Heba Abo-Salem. "Synthesis, antimicrobial and anti-cancer activities of some new N-ethyl, N-benzyl and N-benzoyl-3-indolyl heterocycles." Acta Pharmaceutica 62, no. 2 (2012): 157–79. http://dx.doi.org/10.2478/v10007-012-0020-3.

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Synthesis, antimicrobial and anti-cancer activities of some newN-ethyl,N-benzyl andN-benzoyl-3-indolyl heterocyclesA series of 1-(N-substituted-1H-indol-3-yl)-3-arylprop-2-ene-1-ones (2a, b-4a, b) were prepared and allowed to react with urea, thiourea or guanidine to give pyrimidine derivatives5a, b-13a, b. Reaction of2a, b-4a, bwith ethyl acetoacetate in the presence of a base gave cyclohexanone derivatives14a, b-16a, b. Reaction of the latter compounds with hydrazine hydrate afforded indazole derivatives17a, b-19a, b. On the other hand, reaction of2a, b-4a, bwith some hydrazine derivatives,

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Biagini, Raymond E., Sonela A. Schlottmann, Deborah L. Sammons, et al. "Method for Simultaneous Measurement of Antibodies to 23 Pneumococcal Capsular Polysaccharides." Clinical Diagnostic Laboratory Immunology 10, no. 5 (2003): 744–50. http://dx.doi.org/10.1128/cdli.10.5.744-750.2003.

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ABSTRACT We describe a fluorescent covalent microsphere immunoassay (FCMIA) method for the simultaneous (multiplexed) measurement of immunoglobulin G (IgG) antibodies to 23 pneumococcal capsular polysaccharide (PnPS) serotypes present in the pneumococcal polysaccharide vaccine (PPV23) licensed by the Food and Drug Administration, i.e., PnPSs 1, 2, 3, 4, 5, 6B, 7F, 8, 9N, 9V, 10A, 11A, 12F, 14, 15B, 17F, 18C, 19A, 19F, 20, 22F, 23F, and 33F. In addition, the assay incorporates an internal control that allows for contemporaneous evaluation of the effectiveness of pneumococcal cell wall polysacch

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Šála, Michal, Hubert Hřebabecký, Milena Masojídková, and Antonín Holý. "Synthesis of Novel Racemic Conformationally Locked Carbocyclic Nucleosides Derived from 7-Substituted Bicyclo[2.2.1]hept-5-ene-2,2-dimethanols." Collection of Czechoslovak Chemical Communications 71, no. 5 (2006): 635–49. http://dx.doi.org/10.1135/cccc20060635.

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(1R*,4R*,7S*)-7-Aminobicyclo[2.2.1]hept-5-ene-2,2-dimethanol (15) was prepared in four easy steps from bicyclo[2.2.1]hept-5-ene-2,2-dimethanol (10). Reaction of amine 15 with ethyl N-((E)-3-ethoxymethacryloyl)carbamate afforded thymine derivatives 17a. The amine 15 was used to construct 6-chloro-9H-purine derivative 19a, 2-amino-6-chloro-9H-purine derivative 22a. Ammonolysis of 19a led to the adenine derivative 20a. Treatment of 22a with trifluoroacetic acid afforded guanine nucleoside 23a. (1R*,4R*,7S*)-7-[6-(Cyclopropylamino)-9H-purin-9-yl]bicyclo[2.2.1]hept-5-ene-2,2-dimethanol (21a) and (1

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Del Grosso, Maria, Romina Camilli, Fabio D’Ambrosio, et al. "Increase of pneumococcal serotype 19A in Italy is due to expansion of the piliated clone ST416/CC199." Journal of Medical Microbiology 62, no. 8 (2013): 1220–25. http://dx.doi.org/10.1099/jmm.0.061242-0.

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The emergence of Streptococcus pneumoniae serotype 19A, following use of the heptavalent pneumococcal conjugate vaccine (PCV7), has been favoured by multiple antibiotic resistance of this serotype and by other unknown factors. The aim of this study was to examine 19A isolates from invasive pneumococcal diseases (IPD) obtained before and after PCV7 implementation to ascertain which characteristics, including the presence of pili, might have favoured the emergence of this serotype in Italy. All S. pneumoniae isolates from IPD collected at the Italian National Institute of Health in the years 200

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Yu, J., M. da G. S. Carvalho, B. Beall, and M. H. Nahm. "A rapid pneumococcal serotyping system based on monoclonal antibodies and PCR." Journal of Medical Microbiology 57, no. 2 (2008): 171–78. http://dx.doi.org/10.1099/jmm.0.47549-0.

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Streptococcus pneumoniae expresses at least 91 different polysaccharide (PS) capsules and the currently available serotyping methods are tedious to perform. We have been developing a rapid pneumococcal serotyping assay (named the ‘multibead assay’) based on the capacity of pneumococcal lysates to inhibit the ability of 24 different anti-capsule antibodies to bind to latex beads coated with 24 different PSs (serotypes 1, 3, 4, 5, 6A, 6B, 7F, 9N, 9V, 14, 18C, 19A, 19F, 23F, 2, 8, 10A, 11A, 12F, 15B, 17F, 20, 22F and 33F). Because the polyclonal antibodies used for 10 serotypes (2, 8, 10A, 11A, 1

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Doebele, Carmen, Angelika Bonauer, Ariane Fischer, et al. "Members of the microRNA-17-92 cluster exhibit a cell-intrinsic antiangiogenic function in endothelial cells." Blood 115, no. 23 (2010): 4944–50. http://dx.doi.org/10.1182/blood-2010-01-264812.

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Abstract MicroRNAs are endogenously expressed small noncoding RNAs that regulate gene expression on the posttranscriptional level. The miR-17-92 cluster (encoding miR-17, -18a, -19a/b, -20a, and miR-92a) is highly expressed in tumor cells and is up-regulated by ischemia. Whereas miR-92a was recently identified as negative regulator of angiogenesis, the specific functions of the other members of the cluster are less clear. Here we demonstrate that overexpression of miR-17, -18a, -19a, and -20a significantly inhibited 3-dimensional spheroid sprouting in vitro, whereas inhibition of miR-17, -18a,

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Fenoll, Asunción, Lorenzo Aguilar, María-José Giménez, et al. "Susceptibility of Recently Collected Spanish Pneumococci Nonsusceptible to Oral Penicillin from Serotypes Not Included in the 7-Valent Conjugate Vaccine." Antimicrobial Agents and Chemotherapy 54, no. 6 (2010): 2696–98. http://dx.doi.org/10.1128/aac.01594-09.

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ABSTRACT The susceptibilities of pneumococci recently collected (up to June 2009) in Spain (500 isolates nonsusceptible to oral penicillin and 150 susceptible isolates) from serotypes not included in the conjugate vaccine were determined. Most nonsusceptible isolates (53.6%) belonged to serotype 19A. Susceptibility rates in serotype 19A penicillin-intermediate (n = 201)/penicillin-resistant (n = 67) isolates were <33%/≤6.0% (erythromycin and oral cephalosporins with defined breakpoints), 85.1%/11.9% (amoxicillin), and 96.0%/52.2% (cefotaxime), respectively. Low susceptibility to common oral

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MURPHY, John J., Paul HOBBY, Juan VILARINO-VARELA, et al. "A novel immunoglobulin superfamily receptor (19A) related to CD2 is expressed on activated lymphocytes and promotes homotypic B-cell adhesion." Biochemical Journal 361, no. 3 (2002): 431–36. http://dx.doi.org/10.1042/bj3610431.

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A novel lymphocyte-specific immunoglobulin superfamily protein (19A) has been cloned. The predicted 335-amino-acid sequence of 19A represents a Type 1 membrane protein with homology with the CD2 family of receptors. A molecular model of the two predicted extracellular immunoglobulin-like domains of 19A has been generated using the crystal structure of CD2 as a template. In isolated lymphocytes, expression of 19A is induced by various activation stimuli, and enforced expression of the 19A gene promotes homotypic cell adhesion in a B-cell-line model. Collectively these data imply that the 19A pr

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Layfield, Lester J., and Neal S. Goldstein. "Abstracts. Mod Pathol 2000;13:17A,19A,22A,24A,25A,27A." Modern Pathology 13, no. 8 (2000): 920–21. http://dx.doi.org/10.1038/modpathol.3880167.

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Abo-salem, Heba M., Anhar Abdel-aziem, Inas E. Islam, Mariam M. Yossef, and Eslam R. El-sawy. "SYNTHESIS, ANTIMICROBIAL ACTIVITY AND MOLECULAR DOCKING STUDY OF SOME NEW N-BENZYL AND N-BENZOYL-3-INDOLYL HETEROCYCLES." International Journal of Pharmacy and Pharmaceutical Sciences 8, no. 9 (2016): 224. http://dx.doi.org/10.22159/ijpps.2016v8i9.13184.

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<p><strong>Objective: </strong>Chalcones are one of the major classes of the natural products, which display a wide range of pharmacological properties. Also, chalcones are well-known intermediates for synthesizing various heterocyclic compounds like pyrazoline and pyrimidine derivatives. The present work is designed to synthesize new 3-indolylheterocycles starting from <em>N</em>-benzyl and <em>N</em>-benzoyl-1<em>H</em>-indole-3-carboxaldehyds and evaluating theirs <em>in vitro</em> antimicrobial activity. In addition, the pro

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Brugger, Silvio D., Lukas J. Troxler, Susanne Rüfenacht, et al. "Polysaccharide Capsule Composition of Pneumococcal Serotype 19A Subtypes Is Unaltered among Subtypes and Independent of the Nutritional Environment." Infection and Immunity 84, no. 11 (2016): 3152–60. http://dx.doi.org/10.1128/iai.00474-16.

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Serotype 19A strains have emerged as a cause of invasive pneumococcal disease after the introduction of the 7-valent pneumococcal conjugate vaccine (PCV7), and serotype 19A has now been included in the recent 13-valent vaccine (PCV13). Genetic analysis has revealed at least three different capsular serotype 19A subtypes, and nutritional environment-dependent variation of the 19A capsule structure has been reported. Pneumococcal vaccine effectiveness and serotyping accuracy might be impaired by structural differences in serotype 19A capsules. We therefore analyzed the distribution of 19A subtyp

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Su, Ying-Feng, Yi-Feng Zang, Yu-Hong Wang, and Yin-Lu Ding. "MiR-19-3p Induces Tumor Cell Apoptosis via Targeting FAS in Rectal Cancer Cells." Technology in Cancer Research & Treatment 19 (January 1, 2020): 153303382091797. http://dx.doi.org/10.1177/1533033820917978.

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MicroRNAs are reported as a vital important factor in cancer cell initiation and progression processes. MicroRNA-19-3p has drawn the attention of many researchers in recent years because of its wide expression and its key role in serious kinds of tumor cells. However, the detailed mechanism of microRNA-19a-3p in these tumors is still poorly understood. So, in the present study, we aimed to explore the biological function and potential molecular mechanism of microRNA-19a-3p in different cancer cells. We first detect the relative level of miR-19a-3p in cancer cell lines and tumor tissues compare

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Zhao, Di, Youbin Chen, Shunliang Chen, Chuangyi Zheng, Jun Hu, and Shaowei Luo. "MiR-19a regulates the cell growth and apoptosis of osteosarcoma stem cells by targeting PTEN." Tumor Biology 39, no. 5 (2017): 101042831770534. http://dx.doi.org/10.1177/1010428317705341.

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MicroRNAs are small, endogenous, and non-coding RNAs that play important regulatory roles in multiple biological processes in cancers. Recent evidence has indicated that miR-19a participates in the cancer tumorigenic progression. However, the functional roles of miR-19a in cancer stem cells are still unclear. As the cancer stem cells are considered to be responsible for the tumor recurrence and treatment failure in osteosarcoma, the aim of this study is to investigate the molecular mechanism of miR-19a underlying osteosarcoma tumorigenesis. In this study, we observed significant upregulation o

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Prasad, Salekoppal B. B., Sachin Mysore, C. S. Ashok Raj, Kanchugarakoppalu S. Rangappa, K. Mahadevaiah, and Channapillekoppal S. A. Kumar. "Synthesis of Novel 2,3-Dihydro-5,6-dimethoxy-2-((piperidin-4-yl)methyl) inden-1-one Derivatives as Acetyl Cholinesterase Inhibitors." Current Bioactive Compounds 16, no. 3 (2020): 348–57. http://dx.doi.org/10.2174/1573407214666181113112352.

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Background: Novel carboxamides and thioureas of 2,3-dihydro-5,6-dimethoxy-2-((piperidin- 4-yl)methyl) inden-1-one were synthesized and their potential anticholinesterase activities were evaluated. The inhibition potency of the compounds 17a-j and 19a-j against AChE was measured and evaluated using Ellman’s spectrophotometric method. Among carboxamides series, compound 17f, 17i, 17j and among thiourea series, compound 19a, 19b were found to be the most active. Methods: The scaffold 2,3-dihydro-5,6-dimethoxy-2-((piperidin-4-yl)methyl) inden-1-one 16, key intermediate of drug donepezil has been s

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Liu, Xiaoliang, Xiaojun Zheng, Ying Wang, and Juan Liu. "Dysregulation Serum miR-19a-3p is a Diagnostic Biomarker for Asymptomatic Carotid Artery Stenosis and a Promising Predictor of Cerebral Ischemia Events." Clinical and Applied Thrombosis/Hemostasis 27 (January 2021): 107602962110392. http://dx.doi.org/10.1177/10760296211039287.

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This study aims to identify the diagnostic potential of microRNA-19a-3p (miR-19a-3p) for asymptomatic carotid artery stenosis (CAS) and clinical predictive potential for cerebral ischemia events (CIEs). Serum samples from 101 asymptomatic CAS patients and 98 healthy controls were collected. And it was found that serum miR-19a-3p in asymptomatic CAS patients was generally elevated ( P < .05). Increased miR-19a-3p in asymptomatic CAS was associated with severe CAS (odds ratio = 3.920, 95% confidence interval [CI] = 1.482-10.372, P < .01). The area under the receiver operating characteristi

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Yin, Qian, Pei-Pei Wang, Rui Peng, and Hang Zhou. "MiR-19a enhances cell proliferation, migration, and invasiveness through enhancing lymphangiogenesis by targeting thrombospondin-1 in colorectal cancer." Biochemistry and Cell Biology 97, no. 6 (2019): 731–39. http://dx.doi.org/10.1139/bcb-2018-0302.

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Colorectal cancer (CRC) is a devastating disease with high mortality and morbidity, and the underlying mechanisms of miR-19a in CRC are poorly understood. In our study, dual-luciferase reporter assays were used to evaluate the binding of miR-19a with thrombospondin-1 (THBS1). Cell viability, migration, and invasiveness were assessed using MTT, wound healing, and Transwell assays, respectively. Tube-formation assays with human lymphatic endothelial cells (HLECs) were used to evaluate lymphangiogenesis, and tumor xenograft assays were used to measure tumor growth. The results showed that miR-19a

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Wang, Shuo, Liu Li, Tao Liu, Wenyan Jiang, and Xitian Hu. "miR-19a/19b-loaded exosomes in combination with mesenchymal stem cell transplantation in a preclinical model of myocardial infarction." Regenerative Medicine 15, no. 6 (2020): 1749–59. http://dx.doi.org/10.2217/rme-2019-0136.

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Aim: We aimed to investigate the protection of exogenous miR-19a/19b with bone marrow-derived mesenchymal stem cell (BM-MSC) transplantation on cardiac function and inhibition of fibrosis in myocardial infarction (MI). Materials & methods: BM-MSC-derived exosomes were used to deliver miR-19a/19b (exo/miR-19a/19b) to the cultured cardiac HL-1 cells, and the apoptosis of cells were evaluated. Exo/miR-19a/19b and BM-MSCs were also transplanted to an in vivo MI mouse model. The recovery of cardiac function was assessed and the level of cardiac fibrosis was determined. Results: Exo/miR-19a/19b

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Manfaluthy, Mauludi, Muhammad Syukur, and Adi Supriyadi. "Lowering the NYM 2x1.5mm2 Cable Installation Temperature By Adjusting the Bend Angle." TEKNIK 39, no. 2 (2019): 86. http://dx.doi.org/10.14710/teknik.v39i2.15680.

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Salah satu faktor yang menyebabkan tingginya temperatur pada instalasi kabel listrik adalah posisi kabel yang ditekuk. Pemasangan instalasi listrik di rumah maupun pabrik tidak selalu lurus, dalam keadaan tertentu dan pada lokasi tertentu pemasangan kabel mengharuskan penekukan. Penekukan kabel yang tidak memperhitungkan sudut penekukan menghasilkan kenaikan temperature yang tinggi sehingga memungkinkan terjadinya isolasi terbakar dan kawat penghantar meleleh. Penelitian ini bertujuan untuk menurunkan temperature instalasi Kabel NYM 2 x 1,5mm2 dengan mengatur sudut penekukan. Instalasi kabel N

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Hulten, Kristina G., William J. Barson, P. Ling Lin, et al. "2707. Non 13-Valent Pneumococcal Conjugate Vaccine Serotypes Predominate as Causes of Pneumococcal Otitis Media in Children." Open Forum Infectious Diseases 6, Supplement_2 (2019): S952. http://dx.doi.org/10.1093/ofid/ofz360.2384.

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Abstract Background Pneumococcal acute otitis media (AOM) in children due to vaccine-related serotypes (ST) has declined after the introduction of the 13-valent pneumococcal conjugate vaccine (PCV13), although some serotypes, such has 3, 19A and 19F have persisted. Among non-vaccine serotypes, 35B has been shown to contribute substantially to both OM and invasive infections. This study describes the current epidemiology of pneumococcal OM isolates obtained from the U S Pediatric Multicenter Pneumococcal Surveillance Group (USPMPSG). Methods From the USPMPSG database, we collected data from pat

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Deng, Jingjing, Shu Yang, Qing Yuan, et al. "Acupuncture Ameliorates Postoperative Ileus via IL-6–miR-19a–KIT Axis to Protect Interstitial Cells of Cajal." American Journal of Chinese Medicine 45, no. 04 (2017): 737–55. http://dx.doi.org/10.1142/s0192415x17500392.

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Acupuncture is a therapy effective in treating postoperative ileus (POI); its underlying mechanisms remain unclear. MicroRNAs (miRNAs) participate in inflammation and injury to the interstitial cells of Cajal (ICCs), both of which are considered to be contributors to POI. C-kit, encoding KIT, a specific marker of ICCs, is predicted to be targeted by miR-19a, an inflammation-related miRNA. Therefore, we investigated a possible link between inflammation, miR-19a, and ICCs in POI, as well as the mechanism by which these factors are affected by acupuncture. The effects of acupuncture on POI were a

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Thomas, Matthew F., Carmen L. Sheppard, Malcolm Guiver, et al. "Emergence of pneumococcal 19A empyema in UK children." Archives of Disease in Childhood 97, no. 12 (2012): 1070–72. http://dx.doi.org/10.1136/archdischild-2012-301790.

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IntroductionInvasive pneumococcal disease due to serotype 19A has become a major concern, particularly in the USA and Asia. We describe the characteristics of pneumococcal serotype 19A related empyema and changes in its incidence in the UK.MethodsData from paediatric empyema patients between September 2006 and March 2011 were collected from 17 respiratory centres in the UK. Pneumococcal serotypes were identified as part of the Health Protection Agency enhanced paediatric empyema surveillance programme.ResultsFour serotypes accounted for over 80% of 136 cases (Serotype 1 : 43%, 3 : 21%, 7 : 11%

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Marioni, Gino, Marco Agostini, Rocco Cappellesso, et al. "miR-19a and SOCS-1 expression in the differential diagnosis of laryngeal (glottic) verrucous squamous cell carcinoma." Journal of Clinical Pathology 69, no. 5 (2015): 415–21. http://dx.doi.org/10.1136/jclinpath-2015-203308.

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BackgroundLaryngeal verrucous squamous cell carcinoma (VSCC) is a highly differentiated squamous cell carcinoma (SCC), the diagnosis of which can meet with many pitfalls: benign hyperplastic lesions and conventional SCC are the most important differential diagnoses. The microRNA miR-19a is overexpressed in many solid tumours and regulates the suppressor of cytokine signalling-1 (SOCS-1) expression.AimsThe main endpoints were to assess miR-19a and SOCS-1 expression in glottic VSCC, and the former's potential role in differentiating between glottic VSCC, conventional SCC and hyperplastic lesions

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Tseng, Chih-Hua, Cheng-Ruei Han, and Kai-Wei Tang. "Discovery of 3-Arylquinoxaline Derivatives as Potential Anti-Dengue Virus Agents." International Journal of Molecular Sciences 20, no. 19 (2019): 4786. http://dx.doi.org/10.3390/ijms20194786.

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We designed and synthesized a series of novel 3-arylquinoxaline derivatives and evaluated their biological activities as potential dengue virus (DENV) replication inhibitors. Among them, [3-(4-methoxyphenyl)quinoxalin-2-yl](phenyl)methanol (19a), [6,7-dichloro-3-(4-methoxyphenyl)quinoxalin-2-yl](phenyl)methanol (20a), and (4-methoxyphenyl)(3-phenylquinoxalin-2-yl)methanone (21b) were found to significantly inhibit the DENV RNA expression in Huh-7-DV-Fluc cells with a potency better than that of ribavirin. Compound 19a reduced DENV replication in both viral protein and messenger RNA (mRNA) leve

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Brown, A. M., A. D. Milne, and A. Kay. "The Thistle Field, Blocks 211/18a, 211/19a, UK North Sea." Geological Society, London, Memoirs 20, no. 1 (2003): 383–92. http://dx.doi.org/10.1144/gsl.mem.2003.020.01.32.

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AbstractCumulative production of oil from the Thistle Field had reached almost 400 MMBBL by the end of 2000. Thistle is a success story and has been producing for over 20 years. It is now in its late stage of field life and is close to achieving a 50% recovery factor of its estimated 824 MMBBL STOIIP. The millennium challenge is to continue economic production and further increase reserves recovery. It has survived the full range of oil price fluctuations with all the accompanying cost cutting initiatives in late life becoming the benchmark for end of field life performance.

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