Relevant bibliographies by topics / 2'3'-cGAMP

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  1. Journal articles
  2. Dissertations / Theses

Academic literature on the topic '2'3'-cGAMP'

Author: Grafiati
Published: 22 February 2023
Last updated: 31 July 2025

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Journal articles on the topic "2'3'-cGAMP"

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Taylor, David, Jiajia Ji, Phillip Rzeczycki, Margaret L. Collins, Lauren Clements, and Aileen R. Ariosa. "Abstract 488: Modulation of ENPP1 activity and 2'3'-cGAMP degradation in ovarian cancer cell lines via loadable pre-formed lipid nanoparticles." Cancer Research 84, no. 6_Supplement (2024): 488. http://dx.doi.org/10.1158/1538-7445.am2024-488.

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Abstract Ovarian cancer is a complex heterogeneous disease with various subtypes and diverse molecular mechanisms of pathogenesis. Among different forms, epithelial ovarian cancer is the most common, representing up to 90% of total reported cases. Due to the lack of early diagnostic tools, the prognosis is mainly poor, as most cases are typically identified in advanced stages. Thus, a more thorough understanding of the inherent complexities of the disease, in terms of its biochemical etiology, will allow for identification of specific molecular and genetic profiles that could lead to more effe
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Liu, Pengda, and Yu Deng. "Abstract LB388: Innate immunity-independent roles of 2'3'-cGAMP in tumor metastasis control." Cancer Research 85, no. 8_Supplement_2 (2025): LB388. https://doi.org/10.1158/1538-7445.am2025-lb388.

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Abstract c-di-GAMP was first identified in bacteria to promote colonization, while mammalian 2’3’-cGAMP is synthesized by cGAS to activate STING for innate immune stimulation. However, 2’3’-cGAMP function beyond innate immunity remains elusive. Here, we report 2’3’-cGAMP promotes cell migration independent of innate immunity. 2’3’-cGAMP interactome analysis identifies the small GTPase Rab18 as a 2’3’-cGAMP binding partner and effector in cell migration control. Mechanistically, 2’3’-cGAMP binds Rab18 to facilitate GTP loading and subsequent Rab18 activation, which further promotes FosB transcr
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Gao, Daxing, Jiaxi Wu, Fenghe Du, et al. "Cytosolic sensing of HIV by cGAS (INM2P.350)." Journal of Immunology 194, no. 1_Supplement (2015): 126.3. http://dx.doi.org/10.4049/jimmunol.194.supp.126.3.

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Abstract HIV infection abrogates adaptive immunity by the depletion of CD4 T cells. However, innate immune defense mechanisms against HIV is largely unknown. Here we show that pseudotyped HIV can infect human and mouse cell lines, leading to the production of interferons and other antiviral cytokines. Activation of innate immunity by HIV requires viral cDNA synthesis but not cDNA integration. We show that retrotranscribed HIV cDNA is sensed by the cytosolic DNA sensor cGAS, which then produces the second messenger 2'3'cGAMP to activate the adaptor STING. Importantly, wild type HIV also trigger
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Ariosa, Aileen, David Taylor, Valerie Forsyth, Phil Rzeczycki, and Lauren Clements. "Abstract 2349 Modulation of ENPP1 Activity and 2'3'-cGAMP Degradation in Ovarian Cancer Cell Lines via Loadable Pre-formed Lipid Nanoparticles." Journal of Biological Chemistry 300, no. 3 (2024): 106788. http://dx.doi.org/10.1016/j.jbc.2024.106788.

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Sônego, Fabiane, Gaëlle Martin, Audrey Beringer, et al. "749 A novel translational mouse model for assessment of human STING-targeting therapies." Journal for ImmunoTherapy of Cancer 9, Suppl 2 (2021): A782. http://dx.doi.org/10.1136/jitc-2021-sitc2021.749.

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BackgroundAlthough Immune checkpoint inhibitors (ICI)-targeting therapies have revolutionized the treatment of cancer, several tumors do not respond to those therapies. Preclinical and clinical evidences suggest that STING is a promising target to improve the immunogenicity of tumors, turning them responsive to ICI, and enhancing anti-tumor response. DMXAA failed to show efficacy in clinical trials, despite its encouraging anti-tumor response in preclinical phase, highlighting the need of accurate translational preclinical models. On top of the specificity barrier reported for STING-targeting
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Markham, Matthew, Rebecca S. Maynard, George Bell, et al. "Repolarisation of M2 Macrophages Via Cgas-Sting Activation Enhances Phagocytosis of Acute Myeloid Leukaemia." Blood 144, Supplement 1 (2024): 4113. https://doi.org/10.1182/blood-2024-205265.

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The tumour microenvironment is composed of extracellular matrix and non-mutated cells supporting tumour growth and development. Tumour-associated macrophages are among the most abundant immune cells in the microenvironment. Studies of the innate immune compartment in the bone marrow of patients with acute myeloid leukaemia (AML) reveal a shift toward a tumour-supportive M2-polarised macrophage (Weinhäuser et al., 2023). Furthermore, previous work by our group has shown that AML drives activation of the stimulator of interferon genes (STING) pathway in macrophages in the AML bone marrow microen
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De Silva, Ravindu, Matthew Markham, Rebecca S. Maynard, et al. "Sting Activation in Bone Marrow Macrophages Targets AML Blasts for Phagocytosis in an ICAM-1 Dependent Mechanism." Blood 142, Supplement 1 (2023): 1597. http://dx.doi.org/10.1182/blood-2023-185880.

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The initiation and proliferation of acute myeloid leukaemia (AML) is in part regulated by the bone marrow microenvironment. Previous work by our group has shown that the stimulator of interferon genes (STING) pathway is activated in macrophages in the AML bone marrow microenvironment (Moore et al., 2022) . We found that AML-derived mitochondrial damage-associated molecular patterns were processed by bone marrow macrophages (BMMs) via LC3-associated phagocytosis (LAP). Furthermore, activation of STING resulted in a suppression of AML growth through an LAP dependent mechanism. Here we have inves
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Lea, Spencer, Chao-Hsien Chen, Genevieve Hartley, Rodney Cheng-En Hsieh, and Michael Curran. "763 Intratumoral delivery of high potency STING agonists modulates the immunosuppressive myeloid compartment and induces curative responses in checkpoint-refractory glioblastoma models." Journal for ImmunoTherapy of Cancer 9, Suppl 2 (2021): A798. http://dx.doi.org/10.1136/jitc-2021-sitc2021.763.

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BackgroundGlioblastoma is an aggressive primary brain malignancy that is characterized by a highly suppressive tumor microenvironment, including myeloid-derived suppressor cells, tumor-associated macrophages, and brain-resident microglia, but lacking significant T cell infiltration.1 2 This phenotype is reflected in the recently developed QKi-/- Pten-/- P53-/- (QPP) tumor model,3 which we show is resistant to PD1 or CTLA-4 blockade, but sensitive to agonists of the innate immune sensor Stimulator of Interferon Genes (STING). We have previously shown that agonists of the innate dsDNA-sensing cG
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Ma, Xiao-yu, Man-man Chen, and Ling-hua Meng. "Second messenger 2'3'-cyclic GMP-AMP (2'3'-cGAMP): the cell autonomous and non-autonomous roles in cancer progression." Acta Pharmacologica Sinica, January 4, 2024. http://dx.doi.org/10.1038/s41401-023-01210-7.

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Sintim, Herman O., and Simpa K. Yeboah. "PDE-stable 2'3'-cGAMP analogues, containing 5’-S-phosphorothioester linkage, as STING Agonists." RSC Medicinal Chemistry, 2024. http://dx.doi.org/10.1039/d3md00593c.

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The stimulator of interferon genes (STING) has emerged as a promising target for cancer immunotherapy. 2’3’-cGAMP, a natural agonist of STING, shows anticancer activity via stimulation of immune cells but...
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Dissertations / Theses on the topic "2'3'-cGAMP"

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Dialer, Clemens Reto [Verfasser], and Thomas [Akademischer Betreuer] Carell. "Chemische Synthese und Evaluierung von 2'3'-cGAMP-Analoga / Clemens Reto Dialer ; Betreuer: Thomas Carell." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2020. http://d-nb.info/1237221544/34.

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CUOLLO, LORENZO. "Immunostimulatory activity and regulation of extracellular 2’3’-cGAMP in human multiple myeloma." Doctoral thesis, 2022. http://hdl.handle.net/11573/1630167.

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Multiple myeloma (MM) is a multi-step malignancy arising from the clonal proliferation of antibody- secreting cancerous plasma cells in the bone marrow. The progression of the disease, from the benign condition known as monoclonal gammopathy of undetermined significance (MGUS) to frank MM, is in part due to the gradual loss of immunosurveillance caused by pathological alterations of the bone marrow microenvironment, which affect most cell populations, including mesenchymal stromal cells (BMSCs) and Natural Killer (NK) cells. A promising frontier in cancer immunotherapy is
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