Academic literature on the topic '2-amino pyrimidine'

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Journal articles on the topic "2-amino pyrimidine"

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Borrell, José I., Jordi Teixidó, Blanca Martínez-Teipel, et al. "An Unequivocal Synthesis of 4-Amino-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-2,7-diones and 2-Amino-3,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-4,7-diones." Collection of Czechoslovak Chemical Communications 61, no. 6 (1996): 901–9. http://dx.doi.org/10.1135/cccc19960901.

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An unequivocal set of procedures for the synthesis of 4-amino-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-2,7-diones (7) and 2-amino-3,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-4,7-diones (8), in a maximum of four steps from an α,β-unsaturated ester 1, is reported. Thus, the acid hydrolysis of the 2,4-diaminopyrido[2,3-d]pyrimidines 3 yields the 4-amino-2-oxopyrido[2,3-d]pyrimidines 7 while the cyclization of the Michael adducts 9 (formed by reaction of 1 and methyl cyanoacetate) with guanidine affords the corresponding 2-amino-4-oxopyrido[2,3-d]pyrimidines 8. Both isomers were also obtained by hy
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Sirakanyan, Spinelli, Geronikaki, et al. "Synthesis, Antitumor Activity, and Docking Analysis of New Pyrido[3’,2’:4,5]furo(thieno)[3,2-d]pyrimidin-8-amines." Molecules 24, no. 21 (2019): 3952. http://dx.doi.org/10.3390/molecules24213952.

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Continuing our research in the field of new heterocyclic compounds, herein we report on the synthesis and antitumor activity of new amino derivatives of pyrido[3’,2’:4,5](furo)thieno[3,2-d]pyrimidines as well as of two new heterocyclic systems: furo[2–e]imidazo[1,2-c]pyrimidine and furo[2,3-e]pyrimido[1,2-c]pyrimidine. Thus, by refluxing the 8-chloro derivatives of pyrido[3’,2’:4,5]thieno(furo)[3,2-d]pyrimidines with various amines, the relevant pyrido[3’,2’:4,5]thieno(furo)[3,2-d]pyrimidin-8-amines were obtained. Further, the cyclization of some amines under the action of phosphorus oxychlori
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Tiwari, Sangeeta, Ashok K. Yadav, and A. K. Mishra. "Some New Pyrido[2,3-d]pyridimines and their Nucleoside of Biological Importance." E-Journal of Chemistry 7, s1 (2010): S85—S92. http://dx.doi.org/10.1155/2010/812567.

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Chalcones (I) reacted with malanonitrile and ammonium acetate yielded 2-amino-3-cyano-4,6-disubstituted pyridines (II) in excellent yield. 4-Amino-5,7-disubstituted pyrido [2,3-d]pyrimidine-2(1H)-thiones (III), 4-amino-5,7-disubstituted pyrido[2,3-d]pyrimidines (IV) and 4-imino-3,5,7-trisubstituted pyrido[2,3-d]pyrimidin-2(1H)-ones (V) have been synthesized by the condensation of compound (II) with thiourea, formamide and arylisocynate respectively. The ribofuranosidesviz. 4-amino-5,7-disubstituted-1- [2',3',5'-tri-o-benzoyl-β,D-ribofuranosyl]pyrido[2,3-d]pyrimidine-2-(1H)-thiones (VI) and 4-i
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Abdelhamid, Abdou O., Zeineb H. Ismail, and Anhar Abdel-Aziem. "Reactions with Hydrazonoyl Halides 601: Synthesis of Thieno[2′,3′:4,5] Pyrimidino[1,2-b][1,2,4,5]tetrazines, [1]benzothieno[2′,3′:4,5]pyrimidino [1,2-b][1,2,4,5]tetrazines, Pyrazolo[3′,4′:4,5]pyrimidino[1,2-b] [1,2,4,5]tetrazines and Pyrazolo[3,4-d]pyridazines." Journal of Chemical Research 2007, no. 10 (2007): 609–16. http://dx.doi.org/10.3184/030823407x256118.

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Thieno[2′,3′:4,5]pyrimidino[1,2- b][1,2,4,5]tetrazine, [1]benzothieno-[2′,3′:4,5]pyrimidino[1,2- b][1,2,4,5]tetrazine, pyrazolo [3′,4′:4,5]pyrimidino[1,2- b][1,2,4,5]tetrazine, triazolo[4,3- a]pyrimidin-5(1 H)-one, 1-{[2-(1-benzofuran-2-yl)-5-phenyl-4,5-dihydro-1 H-pyrazol-1-yl]-4-substituted-1,3-thiazol-5-yl}-2-phenyldiazene, 3-acyl-4-(1-benzofuran-2-ylcarbonyl) pyrazole and pyrazolo[3,4- d]pyridazine derivatives could be obtained via reactions of hydrazonoyl halides with the appropriate pyrimidine-2-thione, 3-amino-5,6-dimethyl-2-sulfanylthieno[2,3- d]pyrimidin-4(3 H)-one, 5-amino-6-mercapto
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Hossain, M. I., and M. M. H. Bhuiyan. "Synthesis and Antimicrobial Activities of Some New Thieno and Furopyrimidine Derivatives." Journal of Scientific Research 1, no. 2 (2009): 317–25. http://dx.doi.org/10.3329/jsr.v1i2.2299.

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Fused pyrimidines, 8,9-dimethyl[1,2,4]triazolo[4,3-c]thieno[3,2-e]pyrimidine 5, 3,8,9-trimethyl[1,2,4]triazolo[4,3-c]thieno[3,2-e]pyrimidine 6, 4-benzylidinehydrazono-5,6 dimethylthieno[2,3-d]pyrimidine 7, 4-[4/-hydroxybenzylidine]hydrazono-5,6-dimethylthi-eno[2,3-d]pyrimidine 8, 4-[4/-tolylidin]hydrazono-5,6-dimethylthieno[2,3-d]pyrimidine 9, 4-[4/-nitrobenzylidine]hydrazono-5-ethyl-6-methylthieno[2,3-d]pyrimidine 10 and 4-[4/-chlorobenzylidine]hydrazono-5-ethyl-6-methylthieno[2,3-d]pyrimidine 11 are prepared in good yield by an initial treatment of 2-amino-4,5-dimethylthiophene-3-carbonitril
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Mallikarjunaswamy, C., D. G. Bhadregowda, and L. Mallesha. "Synthesis and Antimicrobial Activity of Pyrimidine Salts with Chloranilic and Picric Acids." Journal of Chemistry 2013 (2013): 1–5. http://dx.doi.org/10.1155/2013/727182.

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Pyrimidine salts such as 2-methyl-5-nitro-phenyl-(4-pyridin-3-yl-pyrimidin-2-yl)-amine (1) and 4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-yl-amino)-phenyl-amine (2) with chloranilic and picric acids were synthesized, and theirin vitroantibacterial and antifungal activities were evaluated. The synthesized compounds were characterized by elemental analyses, UV-visible, FT-IR, and1H NMR spectral studies. Compound2aexhibited good inhibition towards antimicrobial activity compared to the other compounds.
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Ho, Yuh-Wen, and Maw Cherng Suen. "Thioxopyrimidine in Heterocyclic Synthesis I: Synthesis of Some Novel 6-(Heteroatom-substituted)-(thio)pyrimidine Derivatives." Journal of Chemistry 2013 (2013): 1–15. http://dx.doi.org/10.1155/2013/765243.

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A series of novel N-cycloalkanes, morpholine, piperazines, pyrazole, pyrimidine, benzimidazolo[1,2-a]pyrimidine, 1,2,3,4-tetrazolo[1,5-a]pyrimidine, azopyrazolo[1,5- a]pyrimidine, pyrimido[4', 5':3,4]pyrazolo[1,5-a]pyrimidines and pyridine derivatives incorporating a 5-cyano-4-methyl-2-phenyl-(thio)pyrimidine moiety were obtained by the intramolecular cyclization of 6-methylthio-pyrimidine, 6-(benzoylmethyl)thio- pyrimidine and 2-[(5-cyano-4-methyl-2-phenylpyrimidin-6-yl)thio]-3-dimethyl- amino-1-phenyl-prop-2-en-1-one with appropriate amines and enaminone compounds, respectively. The structur
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Harnden, MR, and DT Hurst. "The Synthesis and Chlorination of Some Pyrimidin-4-ols Having 5-Nitrogen Functionality." Australian Journal of Chemistry 43, no. 1 (1990): 47. http://dx.doi.org/10.1071/ch9900047.

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Syntheses of a number of pyrimidin-4-ols having 5-nitrogen functionality are described. Phosphorus oxychloride/diethylaniline chlorination of 6-amino-2-methylthio-5-nitropyrimidin-4-ol gave the corresponding 6-chloro derivative. However, 2-amino-6-methylthio-5-nitropyrimidin-4-ol failed to yield a 4-chloro derivative under the same conditions. Similar chlorination of 2,5-diaminopyrimidine-4,6-diol gave a poor yield of the 4,6-dichloro product but under these conditions 2-amino-5-benzoylaminopyrimidine-4,6-diol* gave 7-chloro-2-phenyloxazolo[5,4-d]pyrimidin-5-amine. 5-Acetylamino-2-methylthiopy
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Harnden, MR, and DT Hurst. "The Chemistry of Pyrimidinethiols. III. The Synthesis of Some Substituted Pyrimidinthiols and Some Thiazolo[5,4-D]pyrimidines." Australian Journal of Chemistry 43, no. 1 (1990): 55. http://dx.doi.org/10.1071/ch9900055.

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The preparation of a number of pyrimidinethiols and (substituted) thiopyrimidines has been carried out. The reaction of 5-acetylamino-2-aminopyrimidine-4,6-diol with phosphorus penta -sulfide in pyridine gave 5-amino-2-methylthiazolo[5,4-d]pyrimidine-7-thiol which was used to prepare several additional novel pyrimidine derivatives. Hydrolysis of the 4-carboxymethylthio derivative by using 5M hydrochloric acid gave 2,5-diamino-6-mercaptopyrimidin-4-ol hy -drochloride whilst hydrolysis of 2-methyl-7-methylthiothiazolo[5,4-d]pyrimidin-5-amine gave the corresponding 4-hydroxy derivative. Several 4
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Mohamed, Mosaad, Ramdan El-Domany, and Rania Abd El-Hameed. "Synthesis of certain pyrrole derivatives as antimicro-bial agents." Acta Pharmaceutica 59, no. 2 (2009): 145–58. http://dx.doi.org/10.2478/v10007-009-0016-9.

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Synthesis of certain pyrrole derivatives as antimicro-bial agentsIn an effort to establish new pyrroles and pyrrolo[2,3-d] pyrimidines with improved antimicrobial activity we report here the synthesis andin vitromicrobiological evaluation of a series of pyrrole derivatives. A series of new 2-aminopyrrole-3-carbonitriles (1a-d) were synthesized from the reaction of benzoin, primary aromatic amines and malononitrile, from which a number of pyrrole derivatives (2a-dto5a-d) and pyrrolo[2,3-d]pyrimidines (6a-dto10a, d) were synthesized. Thein vitroantimicrobial testing of the synthesized compounds
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Dissertations / Theses on the topic "2-amino pyrimidine"

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McLachlan, Janice. "Synthesis of 2-amino-4-(thiazol-5-yl) pyrimidines as potential kinase inhibitors." Thesis, University of Edinburgh, 2006. http://hdl.handle.net/1842/12637.

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Aquino, Estefania da Costa. "Aplicação de 5-bromo-1,1,1-trifluor-4-metoxipent-3-en-2-ona na síntese de pirróis, pirazóis, pirimidinas e 1,2,3-triazóis." Universidade Federal de Santa Maria, 2015. http://repositorio.ufsm.br/handle/1/4275.

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Conselho Nacional de Desenvolvimento Científico e Tecnológico<br>This thesis reports the synthesis of various series of trifluoromethyl substituted nitrogenated heterocycles, such as pyrroles, pyrazoles, pyrimidines and 1,2,3-triazoles, exploiting the synthetic versatility of 5-bromo-1,1,1-trifluoro-4-methoxypent-3-en-2-one in reactions with nitrogenated nucleophiles. In this way, synthesis of a novel series of 4-amino-3-trifluoromethyl-1H-N-substituted pyrroles was performed through two reaction steps. In the first stage is an addition reaction of primary or secondary amine in the 4-position
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Demonchaux, Patrice. "Recherche d'agents radioprotecteurs : synthèse et mécanisme d'action de composés de type intercalant-aminothiol." Grenoble 1, 1988. http://www.theses.fr/1988GRE10016.

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Les intercalants utilises sont des amino-9 chloro-6 methoxy-2 acridines des amino-4 chloro-7 quinoleines et des amino-4 chloro-7 methyl-1 quinoleiniums sur lesquels ont ete introduites des chaines analogues a celles de la cysteamine et du wr 2727; etude de l'affinite de ces composes avec l'adn
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Rostamizadeh, S., N. Shadjou, and E. Isapoor. "MCM-41-nPrNH2 as a Recoverable Nanocatalyst for the Synthesis of New Phenylpyrido[4,3-d]pyrimidin-2-amine Derivatives." Thesis, Sumy State University, 2012. http://essuir.sumdu.edu.ua/handle/123456789/35002.

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MCM-41 anchored n-propylamine (MCM-41-nPrNH2) was found to be a highly efficient and recoverable nanocatalyst for the synthesis of new class of phenylpyrido[4,3-d]pyrimidin-2-amine derivatives under solvent free conditions in high to quantitative yields. All the structures of title compounds 3a-j were elucidated by comprehensive 1H NMR, 13C NMR, IR and Mass spectra When you are citing the document, use the following link http://essuir.sumdu.edu.ua/handle/123456789/35002
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Galve, Murillo Iñaki. "Síntesis de pirido[2,3-d]pirimidin-7(8H)-onas 2-arilamino sustituidas y derivados." Doctoral thesis, Universitat Ramon Llull, 2013. http://hdl.handle.net/10803/101403.

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Les Cinases de Proteïna (PKs) estan implicades en processos fonamentals de la regulació del cicle cel•lular. L’acumulació d’anomalies als mecanismes de control i el comportament disfuncional que se’n deriva han estat detectats a cèl•lules de diferents teixits afectades per càncer, desordres immunològics, endocrins, nerviosos, neurodegenaratius, cardiovasculars, malalties infeccioses, diabetis, Alzheimer, asma, restenosi, arteriosclerosi, leucèmia, artritis, etc. Però d’entre totes les PKs, les Cinases de Tirosina (TKs) han estat destacades com a l’element central de tots aquests processos i, p
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Book chapters on the topic "2-amino pyrimidine"

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Pardasani, R. T., and P. Pardasani. "Magnetic properties of cobalt(II) chloride complex with methyl-2-amino-4-diethylaminothieno[2, 3-d] pyrimidine-6-carboxylate." In Magnetic Properties of Paramagnetic Compounds. Springer Berlin Heidelberg, 2017. http://dx.doi.org/10.1007/978-3-662-53971-2_486.

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Pardasani, R. T., and P. Pardasani. "Magnetic properties of cobalt(II) bromide complex with methyl-2-amino-4-diethylaminothieno[2, 3-d] pyrimidine-6-carboxylate." In Magnetic Properties of Paramagnetic Compounds. Springer Berlin Heidelberg, 2017. http://dx.doi.org/10.1007/978-3-662-53971-2_487.

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Pardasani, R. T., and P. Pardasani. "Magnetic properties of cobalt(II) chloride complex with methyl-2-amino-4-ethylphenylaminothieno[2, 3-d] pyrimidine-6-carboxylate." In Magnetic Properties of Paramagnetic Compounds. Springer Berlin Heidelberg, 2017. http://dx.doi.org/10.1007/978-3-662-53971-2_488.

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Pardasani, R. T., and P. Pardasani. "Magnetic properties of cobalt(II) bromide complex with methyl-2-amino-4-ethylphenylaminothieno[2, 3-d] pyrimidine-6-carboxylate." In Magnetic Properties of Paramagnetic Compounds. Springer Berlin Heidelberg, 2017. http://dx.doi.org/10.1007/978-3-662-53971-2_489.

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Pardasani, R. T., and P. Pardasani. "Magnetic properties of cobalt(II) chloride complex with methyl-2-amino-4-morpholinothieno[2, 3-d] pyrimidine-6-carboxylate." In Magnetic Properties of Paramagnetic Compounds. Springer Berlin Heidelberg, 2017. http://dx.doi.org/10.1007/978-3-662-53971-2_490.

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Pardasani, R. T., and P. Pardasani. "Magnetic properties of cobalt(II) bromide complex with methyl-2-amino-4-morpholinothieno[2, 3-d] pyrimidine-6-carboxylate." In Magnetic Properties of Paramagnetic Compounds. Springer Berlin Heidelberg, 2017. http://dx.doi.org/10.1007/978-3-662-53971-2_491.

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Pardasani, R. T., and P. Pardasani. "Magnetic properties of nickel(II) chloride complex with methyl-2-amino-4-diethylaminothieno[2, 3-d] pyrimidine-6-carboxylate." In Magnetic Properties of Paramagnetic Compounds. Springer Berlin Heidelberg, 2017. http://dx.doi.org/10.1007/978-3-662-53971-2_786.

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Pardasani, R. T., and P. Pardasani. "Magnetic properties of nickel(II) bromide complex with methyl-2-amino-4-diethylaminothieno[2, 3-d] pyrimidine-6-carboxylate." In Magnetic Properties of Paramagnetic Compounds. Springer Berlin Heidelberg, 2017. http://dx.doi.org/10.1007/978-3-662-53971-2_787.

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Pardasani, R. T., and P. Pardasani. "Magnetic properties of nickel(II) chloride complex with methyl-2-amino-4-ethylphenylaminothieno[2, 3-d] pyrimidine-6-carboxylate." In Magnetic Properties of Paramagnetic Compounds. Springer Berlin Heidelberg, 2017. http://dx.doi.org/10.1007/978-3-662-53971-2_788.

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Pardasani, R. T., and P. Pardasani. "Magnetic properties of nickel(II) bromide complex with methyl-2-amino-4-ethylphenylaminothieno[2, 3-d] pyrimidine-6-carboxylate." In Magnetic Properties of Paramagnetic Compounds. Springer Berlin Heidelberg, 2017. http://dx.doi.org/10.1007/978-3-662-53971-2_789.

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Conference papers on the topic "2-amino pyrimidine"

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Mohan, S., and Feridoun Payami. "Laser Raman Spectroscopic Studies On 2-Amino 4 -Methyl Pyrimidine." In 14th Congress of the International Commission for Optics, edited by Henri H. Arsenault. SPIE, 1987. http://dx.doi.org/10.1117/12.967189.

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Pandian, Muthu Senthil, P. Karuppasamy, T. Kamalesh, P. Ramasamy, and Sunil Verma. "Growth of 2-amino 4,6-dimethyl pyrimidine 4-nitrophenol (AMP4N) single crystals for technological applications." In DAE SOLID STATE PHYSICS SYMPOSIUM 2018. AIP Publishing, 2019. http://dx.doi.org/10.1063/1.5113235.

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Prasad, N. L., M. S. Krishnamurthy, and Noor Shahina Begum. "Crystal structure studies of methyl 3-amino-2-cyano-5-(2-fluoro-phenyl)-7-methyl-5H-thiazolo [3,2-a]pyrimidine-6-carboxylate." In WORLD MULTIDISCIPLINARY CIVIL ENGINEERING-ARCHITECTURE-URBAN PLANNING SYMPOSIUM WMCAUS 2022. AIP Publishing, 2023. http://dx.doi.org/10.1063/5.0174743.

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Nikalje, Anna Pratima, Julio Seijas Vázquez, Shailee Tiwari, and Zahid Zaheer. "Ultrasound-promoted One-Pot, Three Component Synthesis Of Novel 5-Amino-2-(4-Chlorophenyl)-7- Substituted Phenyl-8,8a-Dihydro-7H-[1,3,4]Thiadiazolo[3,2-A]Pyrimidine-6-Carbonitrile Derivatives." In The 19th International Electronic Conference on Synthetic Organic Chemistry. MDPI, 2015. http://dx.doi.org/10.3390/ecsoc-19-a048.

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Gangjee, Aleem, Sai Zhao, Lalit Kumar, et al. "Abstract 5492: Study the variation of the glutamate moiety of AG94, a targeted, potent GARFTase inhibitor, as antitumor agents with the 2-amino-6-substituted pyrrolo[2,3-d]pyrimidine scaffold." In Proceedings: AACR 104th Annual Meeting 2013; Apr 6-10, 2013; Washington, DC. American Association for Cancer Research, 2013. http://dx.doi.org/10.1158/1538-7445.am2013-5492.

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Lei, Huajun, Min Wang, Jiaqian Han, and Zhou Lan. "Synthesis of N-methylthieno [2, 3-d] Pyrimidin-4-amine Thienopyrimidine." In 2016 7th International Conference on Education, Management, Computer and Medicine (EMCM 2016). Atlantis Press, 2017. http://dx.doi.org/10.2991/emcm-16.2017.112.

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Wang, Ping, Chengyu Sun, Yueyue Xiao, Chen Chen, Zhenhua Chen, and Wufu Zhu. "Synthesis of 5-(4-Morpholino-7, 8-dihydro-5H-thiopyrano[4,3-d]pyrimidin-2-yl)pyridin-2-amine." In 2015 International Conference on Education, Management, Information and Medicine. Atlantis Press, 2015. http://dx.doi.org/10.2991/emim-15.2015.168.

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Afroz, Ziya, Mohd Faizan, and Shabbir Ahmad. "Crystal structure investigation and natural charge analysis of monohydrated salt of 2,3-pyrazinedicarboxylic acid and 2-amino-5-bromo-6-methyl-4-pyrimidinol." In DAE SOLID STATE PHYSICS SYMPOSIUM 2019. AIP Publishing, 2020. http://dx.doi.org/10.1063/5.0017544.

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Chand, Pooran, Ajit K. Ghosh, Pravin L. Kotian, et al. "Synthesis of (2S,3S,4R,5R)-2-(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-5-(hydroxymethyl)-3-methylpyrrolidine-3,4-diol, an analog of potent HCV inhibitor." In XIIIth Symposium on Chemistry of Nucleic Acid Components. Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, 2005. http://dx.doi.org/10.1135/css200507329.

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Shah, Khushbu, Aamod Dekhne, Zhanjun Hou, Larry Matherly, and Aleem Gangjee. "Abstract 1658: 5N-substituted pyrrolo[3,2-d]pyrimidines: Tumor-targeted agents with first-in-class dual inhibition of serine hydroxymethyl transferase 2 and 5-amino-4-imidazolecarboxamide ribonucleotide formyl transferase enzymes." In Proceedings: AACR Annual Meeting 2018; April 14-18, 2018; Chicago, IL. American Association for Cancer Research, 2018. http://dx.doi.org/10.1158/1538-7445.am2018-1658.

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