Academic literature on the topic '2 amino thiazole / 2 amino -6 methyl Pyridine'

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Journal articles on the topic "2 amino thiazole / 2 amino -6 methyl Pyridine"

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Beuchel, Andreas, Richard Goddard, Peter Imming, and Rüdiger W. Seidel. "A solid solution of ethyl and d 3-methyl 2-[(4-methylpyridin-2-yl)amino]-4-(pyridin-2-yl)thiazole-5-carboxylate." Acta Crystallographica Section E Crystallographic Communications 76, no. 8 (2020): 1255–59. http://dx.doi.org/10.1107/s2056989020008956.

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The synthesis of ethyl 2-[(4-methylpyridin-2-yl)amino)-4-(pyridin-2-yl)thiazole- 5-carboxylate via the Hantzsch reaction and partial in situ transesterification during recrystallization from methanol-d 4 to the d 3-methyl ester, resulting in the title solid solution, ethyl 2-[(4-methylpyridin-2-yl)amino)-4-(pyridin-2-yl)thiazole-5-carboxylate–d 3-methyl 2-[(4-methylpyridin-2-yl)amino)-4-(pyridin-2-yl)thiazole-5-carboxylate (0.88/0.12), 0.88C17H16N4O2S·0.12C16D3H11N4O2S, is reported. The refined ratio of ethyl to d 3-methyl ester in the crystal is 0.880 (6):0.120 (6). The pyridine ring is signi
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Dotsenko, Victor V., Nawras T. Jassim, Azamat Z. Temerdashev, Zainab R. Abdul-Hussein, Nicolai A. Aksenov, and Inna V. Aksenova. "New 6′-Amino-5′-cyano-2-oxo-1,2-dihydro-1′H-spiro[indole-3,4′-pyridine]-3′-carboxamides: Synthesis, Reactions, Molecular Docking Studies and Biological Activity." Molecules 28, no. 7 (2023): 3161. http://dx.doi.org/10.3390/molecules28073161.

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The purpose of this work was to prepare new isatin- and monothiomalondiamide-based indole derivatives, as well as to study the properties of the new compounds. The four-component reaction of 5-R-isatins (R = H, CH3), malononitrile, monothiomalonamide (3-amino-3-thioxo- propanamide) and triethylamine in hot EtOH yields a mixture of isomeric triethylammonium 6′-amino-3′-(aminocarbonyl)-5′-cyano-2-oxo-1,2-dihydro-1′H- and 6′-amino-3′-(aminocarbonyl)- 5′-cyano-2-oxo-1,2-dihydro-3′H-spiro[indole-3,4′-pyridine]-2′-thiolates. The reactivity and structure of the products was studied. We found that oxi
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Harnden, MR, and DT Hurst. "The Chemistry of Pyrimidinethiols. III. The Synthesis of Some Substituted Pyrimidinthiols and Some Thiazolo[5,4-D]pyrimidines." Australian Journal of Chemistry 43, no. 1 (1990): 55. http://dx.doi.org/10.1071/ch9900055.

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The preparation of a number of pyrimidinethiols and (substituted) thiopyrimidines has been carried out. The reaction of 5-acetylamino-2-aminopyrimidine-4,6-diol with phosphorus penta -sulfide in pyridine gave 5-amino-2-methylthiazolo[5,4-d]pyrimidine-7-thiol which was used to prepare several additional novel pyrimidine derivatives. Hydrolysis of the 4-carboxymethylthio derivative by using 5M hydrochloric acid gave 2,5-diamino-6-mercaptopyrimidin-4-ol hy -drochloride whilst hydrolysis of 2-methyl-7-methylthiothiazolo[5,4-d]pyrimidin-5-amine gave the corresponding 4-hydroxy derivative. Several 4
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Kudikala, Sadanandam, Pinnoju Prasad, S. K. Manasa, and Sarasija Madderla. "Synthesis and Anticancer Activity of New 2-methylquinoline with Pyridine, Thiazole and Pyrazole Derivatives." Research Journal of Chemistry and Environment 28, no. 12 (2024): 31–41. https://doi.org/10.25303/2812rjce031041.

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This work presents a novel class of 2-methylquinoline derivatives that combine pyridine, thiazole, pyrazole ring systems. The precursor 1-(2-methylquinolin-3-yl) ethanone (1) is combined with aldehydes, malononitrile and ethyl cyanoacetate in a one-pot synthesis to produce 2-amino-6-(2-methylquinolin-3-yl)-4-phenylpyridine hybrids 2 and 3. Synthetic approaches to the (E)-1-(1-(2-methylquinolin-3-yl) ethylidene) hybrids 5, 6, to treat 1 with thiosemicarbazide and 1-chloropropan-2-one and to get 7, 8, the compound 1 is treated with bromine and thiourea. Then by using 2-chloroacetyl chloride and
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Sabreen, A. Kamal. "In Vitro Antifunal Potential of Morganella morganii and Determination of its Chemical Composition by Gas ChromatographyMass Spectrometry." International Journal of Current Pharmaceutical Review and Research 8, no. 2 (2017): 99–113. https://doi.org/10.5281/zenodo.12677764.

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Bioactives were analyzed using gas chromatography-mass spectroscopy (GC-MS) techniques, then the in vitroantibacterial and antifungal activity of the methanolic extract was evaluated. GC-MS analysis of Morganella morganiirevealed the existence of the Tricyclo[4.3.1.1(3.8)]undecan-1-amine, 3-Methoxybenzaldehyde semicarbazone,carboxaldehyde , 1-methyl-,oxime ,(Z)-(+), 1,5,5-Trimethyl-6-methylene-cyclohexene, 4-(2,5-Dihydro-3-methoxyphenyl)butylamine, Paromomycin , 9-Borabicyclo[3.31]nonane , 9-mercapto-, Benzenemethanol , 2-(2-aminopropoxy)-3-methyl, Acetamide , N-(6-acetylaminobenzothiazol-2-yl
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Sajjad Saad Zghair, Sahar Sarhan Thajeel, and Imad Hadi Hameed. "Characterization of antimicrobial secondary metabolites produced by Klebsiella pneumoniae and screening of its bioactive natural compounds using gas chromatography-mass spectrometry (GC-MS)." International Journal of Life Science Research Archive 5, no. 1 (2023): 076–89. http://dx.doi.org/10.53771/ijlsra.2023.5.1.0071.

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Microbial secondary metabolites are low molecular mass products with unusual structures. The structurally diverse metabolites show a variety of biological activities like antimicrobial agents. Thirty nine bioactive compounds were identified in the methanolic extract of Klebsiella pneumoniae. GC-MS analysis of Klebsiella pneumoniae revealed the existence of the Tricyclo[4.3.1.1(3.8)]undecan-1-amine, 3-Methoxybenzaldehyde semicarbazone, carboxaldehyde , 1-methyl-,oxime ,(Z)-(+), 1,5,5-Trimethyl-6-methylene-cyclohexene, 4-(2,5-Dihydro-3-methoxyphenyl)butylamine, Paromomycin , 9-Borabicyclo[3.31]n
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Gayatri, Kumari. "A Study on X-ray Diffraction of some newly synthesized copper (II) complexes of Mannich bases derived from Thiazole and Pyridine Moieties." Chemistry Research Journal 9, no. 1 (2024): 147–51. https://doi.org/10.5281/zenodo.11275998.

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<strong>Abstract </strong> Three new copper (II) complexes of Mannich bases; p-hydroxybenzylidene-2-aminothiazole and p-hydroxybenzylidene-2-amino-6-methylpyridine have been synthesized and characterized by elemental analyses, magnetic measurements, IR, electronic and ESR spectral studies<sup>1</sup>. In the present paper, the X-ray diffraction analysis of these newly synthesized complexes have been investigated for their powder microcrystalline structure. The values of sin<sup>2</sup>&theta; (observed and calculated), interplanar spacings (d), relative intensities and hkl values of different
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Sun, Hao, and Volker Neugebauer. "mGluR1, but not mGluR5, activates feed-forward inhibition in the medial prefrontal cortex to impair decision making." Journal of Neurophysiology 106, no. 2 (2011): 960–73. http://dx.doi.org/10.1152/jn.00762.2010.

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Cognitive flexibility depends on the integrity of the prefrontal cortex (PFC). We showed previously that impaired decision making in pain results from amygdala-driven inhibition of medial PFC neurons, but the underlying mechanisms remain to be determined. Using whole cell patch clamp in rat brain slices and a cognitive behavioral task, we tested the hypothesis that group I metabotropic glutamate receptors (mGluRs) activate feed-forward inhibition to decrease excitability and output function of PFC pyramidal cells, thus impairing decision making. Polysynaptic inhibitory postsynaptic currents (I
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Sundaraganesan, N., C. Meganathan, and Mustafa Kurt. "Molecular structure and vibrational spectra of 2-amino-5-methyl pyridine and 2-amino-6-methyl pyridine by density functional methods." Journal of Molecular Structure 891, no. 1-3 (2008): 284–91. http://dx.doi.org/10.1016/j.molstruc.2008.03.051.

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Xue, Xiaoyan, Xia Chen та Hongbo Tong. "Dichloridobis{6-methyl-2-[(trimethylsilyl)amino]pyridine-κN1}cobalt(II)". Acta Crystallographica Section E Structure Reports Online 65, № 8 (2009): m957. http://dx.doi.org/10.1107/s1600536809027937.

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Dissertations / Theses on the topic "2 amino thiazole / 2 amino -6 methyl Pyridine"

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Creton, Stuart Kevin. "Cellular and molecular toxicology of the food-derived carcinogen 2-amino-1-methyl-6-phenylimidazo (4,5-b) pyridine (PhIP)." Thesis, Imperial College London, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.411680.

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Kelly, Elizabeth A. "Formation and inhibition of the heterocyclic amine 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in a model system." Thesis, Kansas State University, 2015. http://hdl.handle.net/2097/20520.

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Master of Science<br>Food Science - Animal Sciences and Industry<br>J. Scott Smith<br>Heterocyclic amines (HCAs) are a class of mutagenic and carcinogenic chemical compounds formed on the outside of meat and fish when cooked at high temperatures. 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) is the most abundantly formed HCA. HCAs have been found to cause cancer in mice and rats; PhIP specifically has been found to cause breast, rectal, prostate, and colon cancers. Model systems are often used to replicate the HCA chemical reactions in meat products without causing the many side react
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Nguyen, Thach-Mien Duong. "Synthesis and decomposition kinetics of ester derivative of procarcinogen and promutagen, PhIP, 1-methyl-6-phenylimidazo[4,5-b]pyridine." Oxford, Ohio : Miami University, 2007. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=miami1169670407.

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NGUYEN, DUONG THACH-MIEN. "SYNTHESIS AND DECOMPOSITION KINETICS of ESTER DERIVATIVE of PROCARCINOGEN and PROMUTAGEN, PhIP, 1-methyl-6-phenylimidazo[4,5-b]pyridine." Miami University / OhioLINK, 2007. http://rave.ohiolink.edu/etdc/view?acc_num=miami1169670407.

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Malfatti, Michael Albert. "The impact of glucuronidation on the bioactivation and genotoxicity of the cooked-food carcinogen 2-amino-1-methyl-6 phenylimidazo[4,5-b]pyridine /." For electronic version search Digital dissertations database. Restricted to UC campuses. Access is free to UC campus dissertations, 2005. http://uclibs.org/PID/11984.

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Scholtka, Bettina, Dana Kühnel, Felicitas Taugner, and Pablo Steinberg. "Inflammation does not precede or accompany the induction of perneoplastic lesions in the colon of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine-fed rats." Universität Potsdam, 2009. http://opus.kobv.de/ubp/volltexte/2010/4457/.

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Heterocyclic aromatic amines (HCAs) are formed in meat cooked at high temperatures for a long time or over an open flame. In this context 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), the most abundant HCA in cooked meat, has been suggested to be involved in colon and prostate carcinogenesis. In the latter case it has been reported that: (1) roughly 50% of Fischer F344 male rats treated with PhIP develop carcinomas in the ventral prostate lobe at 1 year of age; (2) inflammation precedes prostatic intraepithelial neoplasia in PhIP-fed rats; (3) inflammation specifically occurs in the
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Kühnel, Dana. "Histologische und molekulargenetische Analyse von Darmgeweben aus mit dem humanrelevanten Kanzerogen 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) behandelten F344-Ratten." Phd thesis, Universität Potsdam, 2005. http://opus.kobv.de/ubp/volltexte/2006/695/.

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Die Entwicklung von Dickdarmkrebs wird durch eine Reihe von Lebens- und Essgewohnheiten sowie Umweltfaktoren begünstigt. Den letzteren beiden sind Substanzen zuzurechnen, die bei der Zubereitung der Nahrung entstehen und mit ihr aufgenommen werden. Zu diesen Verbindungen gehört das 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridin (PhIP) aus der Substanzklasse der heterozyklischen aromatischen Amine. Es entsteht bei der Erhitzung zahlreicher proteinhaltiger Nahrungsmittel und die Zielorgane in Nagerstudien stimmen mit der Häufung von Krebsinzidenzen in westlichen Industrienationen überein. Dieser
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Qian, Zheng. "Analysis of DNA damage induced by 2-hydroxy amino-1-methyl-6-phenyl-imidazol [4,5-b] pyridine (N-OH-PHIP) in the mutation cluster region of the human APC gene." Available to US Hopkins community, 2002. http://wwwlib.umi.com/dissertations/dlnow/3068198.

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Smith-Roe, Stephanie L. "DNA mismatch repair-dependent responses to the food-borne carcinogen 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in the mouse." Thesis, 2006. http://hdl.handle.net/1957/29017.

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Kühnel, Dana [Verfasser]. "Histologische und molekulargenetische Analyse von Darmgeweben aus mit dem humanrelevanten Kanzerogen 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) behandelten F344-Ratten / von Dana Kühnel." 2006. http://d-nb.info/980632404/34.

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Conference papers on the topic "2 amino thiazole / 2 amino -6 methyl Pyridine"

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Yao-Borengasser, Aiwei, Lora J. Rogers, and Susan A. Kadlubar. "Abstract 5303: Uptake and Efflux of 2-amino-1-methyl-6-phenylimidazo [4, 5-b] pyridine (PhIP) in human adipocytes." In Proceedings: AACR Annual Meeting 2014; April 5-9, 2014; San Diego, CA. American Association for Cancer Research, 2014. http://dx.doi.org/10.1158/1538-7445.am2014-5303.

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Choudhary, Shambhunath, Shilpa Sood, Kusum Rathore, and Hwa-Chain Robert Wang. "Abstract 5467: Green tea catechin intervention of human breast cell carcinogenesis chronically induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine." In Proceedings: AACR 103rd Annual Meeting 2012‐‐ Mar 31‐Apr 4, 2012; Chicago, IL. American Association for Cancer Research, 2012. http://dx.doi.org/10.1158/1538-7445.am2012-5467.

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Alva, Rayford, Brian Yuen Yau Wong, John Tanner, Yanlingxue Wan, Padma Tadi Uppala, and Ryan Hayes. "Abstract 4017: Inhibition of mutagenicity of PhIP (2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine)by Chinese medicinal herbs Scutellaria barbata and Oldenlandia diffusa." In Proceedings: AACR Annual Meeting 2018; April 14-18, 2018; Chicago, IL. American Association for Cancer Research, 2018. http://dx.doi.org/10.1158/1538-7445.am2018-4017.

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Wan, Yanlingxue, Ryan Hayes, Joshua Li, Kristin Ferrer, Padma T. Uppula, and Brian Yuen Yau Wong. "Abstract 5091: Inhibition of mutagenicity of 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine ( PhIP) by aqueous extract (crude) and organic extract (pulegone) ofCalamintha nepeta." In Proceedings: AACR Annual Meeting 2019; March 29-April 3, 2019; Atlanta, GA. American Association for Cancer Research, 2019. http://dx.doi.org/10.1158/1538-7445.sabcs18-5091.

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Wan, Yanlingxue, Ryan Hayes, Joshua Li, Kristin Ferrer, Padma T. Uppula, and Brian Yuen Yau Wong. "Abstract 5091: Inhibition of mutagenicity of 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine ( PhIP) by aqueous extract (crude) and organic extract (pulegone) ofCalamintha nepeta." In Proceedings: AACR Annual Meeting 2019; March 29-April 3, 2019; Atlanta, GA. American Association for Cancer Research, 2019. http://dx.doi.org/10.1158/1538-7445.am2019-5091.

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