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Journal articles on the topic '2-Aminonicotin acid'

Author: Grafiati

Published: 5 June 2025

Last updated: 2 August 2025

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1

Dobson, A. J., and R. E. Gerkin. "2-Aminonicotinic Acid." Acta Crystallographica Section C Crystal Structure Communications 53, no. 10 (1997): 1427–29. http://dx.doi.org/10.1107/s0108270197008226.

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2

Quevedo, Camilo E., Vassilios Bavetsias, and Edward McDonald. "Microwave-assisted synthesis of 2-aminonicotinic acids by reacting 2-chloronicotinic acid with amines." Tetrahedron Letters 50, no. 21 (2009): 2481–83. http://dx.doi.org/10.1016/j.tetlet.2009.03.034.

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3

OHBA, Yoshihito, Miyuki SAKATA, and Kiyoshi ZAITSU. "Chemiluminescence Derivatization of Methylglyoxal Using 2-Aminonicotinic Acid." CHEMICAL & PHARMACEUTICAL BULLETIN 48, no. 8 (2000): 1236–38. http://dx.doi.org/10.1248/cpb.48.1236.

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4

Khodjaniyazov, Hamid Utkirovich. "SYNTHESIS AND NMR SPECTRAL CHARACTERIZATION OF NOVEL 2,3-POLYMETHYLENEPYRIDO[2,3-D]PYRIMIDIN-4-ONES." JOURNAL OF ADVANCES IN CHEMISTRY 11, no. 8 (2015): 3873–75. http://dx.doi.org/10.24297/jac.v11i8.2193.

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We have synthesized of novel 2,3-polymethylenepyrido[2,3-d]pyrimidin-4-ones via condensation of the 2-aminonicotinic acid together with lactams in the presence of phosphorus oxychloride. The structures of the newly synthesized pyrido[2,3-d]pyrimidines were confirmed by 1H and 13c NMR spectral data.

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5

Akhundov, R. A., L. A. Zhmurenko, O. M. Glozman, T. A. Voronina, and V. A. Zagorevskii. "Synthesis and psychotropic activity of amides of 2-aminonicotinic acid." Pharmaceutical Chemistry Journal 20, no. 1 (1986): 32–35. http://dx.doi.org/10.1007/bf00766874.

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6

Ramesh Raju, R., S. Krishna Mohan, and S. Jayarama Reddy. "Electroorganic synthesis of 6-aminonicotinic acid from 2-amino-5-chloropyridine." Tetrahedron Letters 44, no. 21 (2003): 4133–35. http://dx.doi.org/10.1016/s0040-4039(03)00816-5.

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7

SONNENBURG, R., I. NEDA, A. FISCHER, P. G. JONES, and R. SCHMUTZLER. "ChemInform Abstract: Synthesis of Phosphorus-Containing Heterocycles from 2-Aminonicotinic Acid." ChemInform 26, no. 39 (2010): no. http://dx.doi.org/10.1002/chin.199539193.

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8

Nayak, Manoj K., and Sneh K. Dogra. "Excited state prototropism in 2-aminonicotinic acid: effect of solvents and acid–base concentrations." Journal of Photochemistry and Photobiology A: Chemistry 171, no. 3 (2005): 281–90. http://dx.doi.org/10.1016/j.jphotochem.2004.09.017.

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9

Nawaz, Muhammad, Muhammad Waseem Abbasi, Soleiman Hisaindee, et al. "Synthesis, spectral studies and biological evaluation of 2-aminonicotinic acid metal complexes." Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 161 (May 2016): 39–43. http://dx.doi.org/10.1016/j.saa.2016.02.022.

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10

Wright, Stephen W. "Preparation of 2-, 4-, 5-, and 6-aminonicotinic acid tert-butyl esters." Journal of Heterocyclic Chemistry 49, no. 2 (2012): 442–45. http://dx.doi.org/10.1002/jhet.799.

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11

Smrčková, Svatava, Kristina Juricová, and Viktor Prutianov. "Study of Amino-Imino Tautomerism in Derivatives of 2-, 4- and 6-Aminonicotinic Acid." Collection of Czechoslovak Chemical Communications 59, no. 9 (1994): 2057–68. http://dx.doi.org/10.1135/cccc19942057.

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13C NMR spectra of p-nitrobenzoyl 2-, 4-, and 6-aminopyridine-3-carboxylates, their hydrochlorides, trifluoroacetates and 1-benzyl derivatives were studied. As found from the chemical shifts of pyridine carbon atoms C-2, C-4 and C-6, the free bases exist in the amino form whereas hydrochlorides and 1-substituted pyridinium derivatives in the imino form. Trifluoroacetates of the 2- and 6-amino derivatives have structure similar to that of amidiniumcarboxylates (parallel hydrogen bonds and partially ionic character) whereas trifluoroacetate of the 4-amino derivative is structurally close to the

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12

Beccalli, Egle M., Francesca Clerici, and Maria Luisa Gelmi. "Isothiazoles. Part 11: 3-Azahexatrienes from 2-Arylpropenamidines: Electrocyclization to 6-Aminonicotinic Acid Derivatives." Tetrahedron 56, no. 27 (2000): 4817–21. http://dx.doi.org/10.1016/s0040-4020(00)00399-9.

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13

Wright, Stephen W. "ChemInform Abstract: Preparation of 2-, 4-, 5-, and 6-Aminonicotinic Acid tert-Butyl Esters." ChemInform 43, no. 36 (2012): no. http://dx.doi.org/10.1002/chin.201236143.

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14

SMRCKOVA, S., K. JURICOVA, and V. PRUTIANOV. "ChemInform Abstract: Amino-Imino Tautomerism in Derivatives of 2-, 4- and 6-Aminonicotinic Acid." ChemInform 26, no. 11 (2010): no. http://dx.doi.org/10.1002/chin.199511158.

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15

Pagacz-Kostrzewa, M., M. A. Kochman, W. Gul, and M. Wierzejewska. "Phototransformations of 2-aminonicotinic acid resolved with matrix isolation infrared spectroscopy and ab initio calculations." Journal of Photochemistry and Photobiology A: Chemistry 410 (April 2021): 113187. http://dx.doi.org/10.1016/j.jphotochem.2021.113187.

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16

Soares-Santos, Paula C. R., Rute A. Sá Ferreira, Tito Trindade, Luís D. Carlos, and Helena I. S. Nogueira. "Terbium(III) complexes of 2-aminonicotinic, thiosalicylic and anthranilic acids: synthesis and photoluminescence properties." Journal of Alloys and Compounds 451, no. 1-2 (2008): 575–77. http://dx.doi.org/10.1016/j.jallcom.2007.04.113.

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17

Sarıkaya, Muhsin, and Hüseyin Enginar. "Radio Labeling of 2 - Aminonicotinic Acid with 131 I and Biodistribution on the Albino Wistar Rats." Afyon Kocatepe University Journal of Sciences and Engineering 13, no. 1 (2013): 1–8. http://dx.doi.org/10.5578/fmbd.5418.

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18

Beccalli, Egle M., Francesca Clerici, and Maria Luisa Gelmi. "ChemInform Abstract: Isothiazoles. Part 11. 3-Azahexatrienes from 2-Arylpropenamidines: Electrocyclization to 6-Aminonicotinic Acid Derivatives." ChemInform 31, no. 43 (2000): no. http://dx.doi.org/10.1002/chin.200043154.

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19

Sreeram, V., M. V. Basaveswara Rao та Koya Prabhakara Rao. "Impact of 2-Aminonicotinic Acid and/or β-Cyclodextrin on the Morphology of Metal Carbonates (M = Ca2+ and Sr2+) Crystallization". Asian Journal of Chemistry 32, № 2 (2019): 435–40. http://dx.doi.org/10.14233/ajchem.2020.22447.

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We examined the crystallization impact of the surfactant, 2-aminonicotinic acid and/or β-cyclodextrin on the formation of two anhydrous metal carbonates, MCO3 (M = Ca2+ and Sr2+), from their respective calcium chloride and strontium chloride salts along with NaHCO3 at room temperature. By varying the concentrations of this hybrid surfactant to the concentrations of MCO3 during the preparations and examined their particle sizes by PXRD, FTIR, TGA and SEM. The characterization on these newly formed anhydrous metal carbonates clearly indicated that CaCO3 formed with three different shapes such as

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20

Sonawane, Ravindra S., Kiran D. Patil, and Avinash V. Patil. "Design, Synthesis and Pharmacological Evaluation of Novel Imidazopyridine Analogues as Proton Pump Antagonist." Asian Journal of Chemistry 32, no. 4 (2020): 776–82. http://dx.doi.org/10.14233/ajchem.2020.22433.

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A series of novel imidazopyridine derivatives as proton pump inhibitors was designed with compounds of CID data base and explored considering AZD0865 as standard. Many compounds were identified and docked in proton pump ATPase pocket (PDB ID: 4ux2). Molecular docking studies revealed that many compounds showed good proton pump ATPase inhibitory activity. The docking poses revealed the interaction of ligands with amino acid. The standard drug AZD0865 had docking score of -7.112302 and displayed interactions with Asn138 and Asp137. A series of novel imidazopyridine derivatives as proton pump inh

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21

Surov, Artem O., Nikita A. Vasilev, Andrei V. Churakov, et al. "Two Faces of Water in the Formation and Stabilization of Multicomponent Crystals of Zwitterionic Drug-Like Compounds." Symmetry 13, no. 3 (2021): 425. http://dx.doi.org/10.3390/sym13030425.

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Two new hydrated multicomponent crystals of zwitterionic 2-aminonicotinic acid with maleic and fumaric acids have been obtained and thoroughly characterized by a variety of experimental (X-ray analysis and terahertz Raman spectroscopy) and theoretical periodic density functional theory calculations, followed by Bader analysis of the crystalline electron density) techniques. It has been found that the Raman-active band in the region of 300 cm−1 is due to the vibrations of the intramolecular O-H...O bond in the maleate anion. The energy/enthalpy of the intermolecular hydrogen bonds was estimated

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22

Wang, Dong-Xiao, Hong-Bo Liu, Ya-Guang Chen, and Shan Wei. "Protonated 2-Aminonicotinic Acid as Charge Complement in POM-Based Inorganic–Organic Hybrids: Synthesis, Crystal Structure and Characterization." Journal of Cluster Science 26, no. 5 (2015): 1567–76. http://dx.doi.org/10.1007/s10876-015-0851-4.

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23

Sonawane, R. S., Mrunal Shirsat, S. R. Patil, J. C. Hundiwale, and A. V. P. atil. "Design and Synthesis of Novel Imidazopyridine Analogues and Evaluation as H+/K+-ATPase Antagonist." Asian Journal of Chemistry 32, no. 11 (2020): 2685–92. http://dx.doi.org/10.14233/ajchem.2020.22697.

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CID data base were explored considering AZD0865 as standard and docked in proton pump ATPase pocket (PDB ID: 4ux2) to find out novel imidazopyridine derivatives as proton pump inhibitors. A number of compounds showed good proton pump ATPase inhibitory activity as per the molecular docking study as compared to standard compound AZD0865. The compound AZD0865showed a docking score of -7.11 and revealed the interactions with amino acids Asn 138 and Asp 137. A series of novel imidazopyridine derivatives as proton pump inhibitors were docked, synthesized and characterized by IR, NMR, CHN and MS spec

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24

Vallerini, Gian Paolo, Laura Amori, Claudia Beato, et al. "2-Aminonicotinic Acid 1-Oxides Are Chemically Stable Inhibitors of Quinolinic Acid Synthesis in the Mammalian Brain: A Step toward New Antiexcitotoxic Agents." Journal of Medicinal Chemistry 56, no. 23 (2013): 9482–95. http://dx.doi.org/10.1021/jm401249c.

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25

Zografos, Alexandros L., Christos A. Mitsos, and Olga Igglessi-Markopoulou. "Chemoselective Cyclization of Aminonicotinic Acid Derivatives to 1,8-Naphthyridin-2-ones via a Potential Intramolecular Azadiene-Ketene Electrocyclization Reaction." Journal of Organic Chemistry 66, no. 12 (2001): 4413–15. http://dx.doi.org/10.1021/jo0057553.

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26

Feng, Qiuju, Kelong Huang, Suqin Liu, and Xuanyun Wang. "Electrocatalytic carboxylation of 2-amino-5-bromopyridine with CO2 in ionic liquid 1-butyl-3-methyllimidazoliumtetrafluoborate to 6-aminonicotinic acid." Electrochimica Acta 55, no. 20 (2010): 5741–45. http://dx.doi.org/10.1016/j.electacta.2010.05.010.

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27

Morsali, Ali, Akram Panjehpour, and Sang Woo Joo. "Sonochemical Synthesis of Nano-structured Lead(II) Coordination Polymer with 2-Aminonicotinic Acid: Thermal, Structural and X-ray Powder Diffraction Studies." Journal of Inorganic and Organometallic Polymers and Materials 22, no. 6 (2012): 1341–49. http://dx.doi.org/10.1007/s10904-012-9771-z.

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28

Zografos, Alexandros L., Christos A. Mitsos, and Olga Igglessi-Markopoulou. "ChemInform Abstract: Chemoselective Cyclization of Aminonicotinic Acid Derivatives to 1,8-Naphthyridin-2-ones via a Potential Intramolecular Azadiene-Ketene Electrocyclization Reaction." ChemInform 32, no. 40 (2010): no. http://dx.doi.org/10.1002/chin.200140141.

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29

Tabanlıgil Calam, Tuğba, and Gülşen Taşkın. "Optimization of voltammetric parameters for sensitive and simultaneous determination of ferulic acid and vanillin using a glassy carbon electrode based on 2-aminonicotinic acid in the presence of surfactant media." Food Chemistry 436 (March 2024): 137752. http://dx.doi.org/10.1016/j.foodchem.2023.137752.

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30

Bartzatt, Ronald. "Alkylation Activity and Molecular Properties of Two Antineoplastic Agents that Utilise Indometacin and a Conjugate of Aspirin with 2-Aminonicotinic Acid to Transport Nitrogen Mustard Groups." Drugs in R & D 8, no. 6 (2007): 363–72. http://dx.doi.org/10.2165/00126839-200708060-00004.

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31

Karabacak, Mehmet, Etem Kose, and Ahmet Atac. "Molecular structure (monomeric and dimeric structure) and HOMO–LUMO analysis of 2-aminonicotinic acid: A comparison of calculated spectroscopic properties with FT-IR and UV–vis." Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 91 (June 2012): 83–96. http://dx.doi.org/10.1016/j.saa.2012.01.072.

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32

D., E. Turgunov. "SYNTHESIS OF PHOSPHONIC ACIDS OF POLYFUNCTIONAL PYRIDOPYRIMIDINES." June 11, 2023. https://doi.org/10.5281/zenodo.8025261.

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<em>In the article synthesized 2,3-trimethylene-3,4-dihydropyrido[2,3-d] pyrimidin-4-one from 2-Aminonicotinic acid and pyrrolidone-2 in the presence different agents, such as PCl<sub>5</sub>, POCl<sub>3</sub>. Its reduction reaction with NaBH<sub>4</sub> carrying out. Obtained 2,3-trimethylene-1,2,3,4-tetrahydropyrido[2,3-d] pyrimidin-4-one – this three-component coupling of a carbonyl, an amine and a hydrophosphoryl compoud leads to </em><em>α</em><em>-aminophosphonates, phosphorous acid-formaldehyde; aldehydes in three component system; minomethylphosphonic acid synthesis based

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33

Quevedo, Camilo E., Vassilios Bavetsias, and Edward McDonald. "ChemInform Abstract: Microwave-Assisted Synthesis of 2-Aminonicotinic Acids by Reacting 2-Chloronicotinic Acid with Amines." ChemInform 40, no. 36 (2009). http://dx.doi.org/10.1002/chin.200936144.

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34

AKHUNDOV, R. A., L. A. ZHMURENKO, O. M. GLOZMAN, T. A. VORONINA, and V. A. ZAGOREVSKII. "ChemInform Abstract: Synthesis and Psychotropic Activity of 2-Aminonicotinic Acid Amides." Chemischer Informationsdienst 17, no. 28 (1986). http://dx.doi.org/10.1002/chin.198628235.

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35

Bhatt, Keval, Dhara Patel, Mrudangsinh Rathod, Ashish Patel, and Drashti Shah. "Efficient synthesis and characterization of imidazo[1,2‐a]pyridine‐8‐carboxamide derivatives: A promising scaffold for drug development." Vietnam Journal of Chemistry, April 23, 2024. http://dx.doi.org/10.1002/vjch.202300362.

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AbstractImidazo[1,2‐a]pyridine, a pivotal fused heterocycle with widespread applications in medicinal chemistry, serves as a foundational scaffold for numerous pharmaceutical compounds. This present approach introduces a highly efficient multi‐step synthetic methodology for imidazo[1,2‐a]pyridine‐8‐carboxamide derivatives through a condensation reaction between 2‐aminonicotinic acid and chloroacetaldehyde in an environmentally friendly ethanol solvent followed by acid‐amine coupling reaction with a substituted amine. This coupling reaction employs an HATU catalyst and DIPEA strong base and aff

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36

Chen, Nuo, Qing-Hua Zheng, Wang Zhao, and Wei-Wei Zhou. "The crystal structure of catena-poly[5-aminonicotinic acid-k¹ N-m₂-bromido-copper(I)], Cu(C₆N₂H₆O₂)Br." Zeitschrift für Kristallographie - New Crystal Structures, June 1, 2023. http://dx.doi.org/10.1515/ncrs-2023-0196.

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Abstract [Cu(C6N2H6O2)Br] n , monoclinic, P21/c (no. 14), a = 16.536(6) Å, b = 3.8463(14) Å, c = 14.403(6) Å, β = 115.009 ( 5 ) ∘ $115.009{(5)}^{\circ }$ , V = 830.2(6) Å3, Z = 4, Rgt (F) = 0.0441, wRref (F 2) = 0.1054, T = 296 K.

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