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Journal articles on the topic '2-Aminopyridine-3-carboxylic acid'

Author: Grafiati

Published: 5 June 2025

Last updated: 2 August 2025

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1

Marandi, Ghasem. "Synthesis of 3-(Cyclohexylamino)-2-arylimidazo[1,2-a]pyridine-8- carboxylic Acids Via an Efficient Three-component Condensation Reaction between Cyclohexylisocyanide and 2-Aminopyridine-3-carboxylic Acid in the Presence of Aromatic Aldehyde." Combinatorial Chemistry & High Throughput Screening 21, no. 4 (2018): 298–301. http://dx.doi.org/10.2174/1386207321666180416153112.

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Aim and Objective: The reaction of cyclohexylisocyanide and 2-aminopyridine-3- carboxylic acid in the presence of benzaldehyde derivatives in ethanol led to 3-(cyclohexylamino)-2- arylimidazo[1,2-a]pyridine-8-carboxylic acids in high yields. In a three component condensation reaction, isocyanide reacts with 2-aminopyridine-3-carboxylic acid and aromatic aldehydes without any prior activation. Material and Methods: The synthesized products have stable structures which have been characterized by IR, 1H, 13C and Mass spectroscopy as well as CHN-O analysis. Results: In continuation of our attempts

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2

A. Jackson, Yvette, and Mark F. Williams. "Heterocycles from 2-Aminopyridine and Derivatives of 3-Methylbenzofuran-2-carboxylic Acid." HETEROCYCLES 45, no. 4 (1997): 787. http://dx.doi.org/10.3987/com-96-7660.

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3

Wang, Dan, Shu-Mu Li, Yu-Fei Li, Xiang-Jun Zheng, and Lin-Pei Jin. "Hydrogen bond-assisted aggregation-induced emission and application in the detection of the Zn(ii) ion." Dalton Transactions 45, no. 20 (2016): 8316–19. http://dx.doi.org/10.1039/c6dt00265j.

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3-Aminopyridine-2-carboxylic acid can serve as an AIE-active turn on fluorescence chemosensor for Zn<sup>2+</sup>. The AIE behaviors are attributed to the cooperative effect of J-aggregation and hydrogen bonds. And selecting proper ratio of the solvents can prove the sensitivity.

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4

JACKSON, Y. A., and M. F. WILLIAMS. "ChemInform Abstract: Heterocycles from 2-Aminopyridine and Derivatives of 3- Methylbenzofuran-2-carboxylic Acid." ChemInform 28, no. 41 (2010): no. http://dx.doi.org/10.1002/chin.199741139.

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5

Chen, QP, and LW Deady. "Synthesis of Some Benzo[b][1,6]naphthyridines and Benzo[b][1,7]naphthyridines." Australian Journal of Chemistry 46, no. 7 (1993): 987. http://dx.doi.org/10.1071/ch9930987.

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Pfitzinger (1-benzylpiperidin-4-one with 7-methylisatin) and Friedlander (3-aminopyridine-4-carbaldehyde with 2-methylcyclohexanone) syntheses, respectively, were used to prepare the title 'azaacridines' containing a methyl substituent peri to the central nitrogen. Oxidation of this group gave the corresponding aldehyde and carboxylic acid. In the [1,6] case, especially, the 10-position was also easily oxidized to give acridone analogues. Nitration occurred exclusively in the benzenoid rings.

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6

Putaya, Habila A. N., Naomi P. Ndahi, Hauwa S. Bello, Grema Mala, Adekunle A. Osunlaja, and Hussaini Garba. "Synthesis, characterization and antimicrobial analysis of Schiff bases of o-phenylenediamine and 2-aminopyridine-3-carboxylic acid with ofloxacin and their metal (II) complexes." International Journal of Biological and Chemical Sciences 14, no. 1 (2020): 263–78. http://dx.doi.org/10.4314/ijbcs.v14i1.22.

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The increasing multi-drug resistance of microbes to the existing anti-biotic drugs has been of great concern to medical scientists and challenge has directly concerned pharmacologists, inorganic chemists, molecular microbiologists etc. This work attempted modifying a second generation fluoroquinolone (ofloxacin) toward attaining more improved activity. Schiff base Ligands HL1 and HL2 were obtained from separate condensation of o-phenylenediamine and 2-aminopyridine-3-carboxylic acid with ofloxacin in 2:1 and 1:1 mole ratio respectively. These ligands were complexed with chloride salts of Ni (I

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7

de Mesquita, Maria E., Gilberto F. de Sá, and Oscar L. Malta. "Spectroscopic studies of the Eu(III) and Gd(III) tris(3-aminopyridine-2-carboxylic acid) complexes." Journal of Alloys and Compounds 250, no. 1-2 (1997): 417–21. http://dx.doi.org/10.1016/s0925-8388(96)02561-3.

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8

Habila, A. N. Putaya, P. Ndahi Naomi, Mala Grema, Z. Kyari Modu, and Garba Hussaini. "Synthesis, Characterization and Antimicrobial Assessment of Ofloxacin Derivatives and Their Complexes with Cobalt(II) and Copper(II) Metals." Chemistry Research Journal 4, no. 4 (2019): 23–34. https://doi.org/10.5281/zenodo.13312285.

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Schiff base Ligands HL<sup>1</sup> and HL<sup>2</sup> were synthesized by separate condensation of o-phenylenediamine and 2-aminopyridine-3-carboxylic acid with ofloxacin in 2:1 and 1:1 mole ratio respectively. These ligands were reacted with chloride salts of Co(II)  and Cu(II) to obtain (HL<sup>1</sup>) and (HL<sup>2</sup>)-Metal complexes respectively. The novel compounds were characterized using physicochemical properties, IR spectroscopy, UV-visible spectroscopy, Molar conductance and metal analysis. The IR and UV/vis spectra revealed that the metal ions coordinated with the ligands

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9

Prakash, Shet M., S. Naveen, N. K. Lokanath, P. A. Suchetan, and Ismail Warad. "Crystal structures of 2-aminopyridine citric acid salts: C5H7N2 +·C6H7O7 − and 3C5H7N2 +·C6H5O7 3−." Acta Crystallographica Section E Crystallographic Communications 74, no. 8 (2018): 1111–16. http://dx.doi.org/10.1107/s2056989018009787.

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2-Aminopyridine and citric acid mixed in 1:1 and 3:1 ratios in ethanol yielded crystals of two 2-aminopyridinium citrate salts, viz. C5H7N2 +·C6H7O7 − (I) (systematic name: 2-aminopyridin-1-ium 3-carboxy-2-carboxymethyl-2-hydroxypropanoate), and 3C5H7N2 +·C6H5O7 3− (II) [systematic name: tris(2-aminopyridin-1-ium) 2-hydroxypropane-1,2,3-tricarboxylate]. The supramolecular synthons present are analysed and their effect upon the crystal packing is presented in the context of crystal engineering. Salt I is formed by the protonation of the pyridine N atom and deprotonation of the central carboxyli

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10

Srivastava, Ashish Kumar, Krishna Srivastava, and Jagdish Prasad. "Synthesis, characterization, spectroscopic and electrochemical investigation of 2-aminopyridine-3-carboxylic acid copper(II) complexes with diimine." Chemical Data Collections 24 (December 2019): 100272. http://dx.doi.org/10.1016/j.cdc.2019.100272.

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11

Radha, G. K., Mahesha, S. Naveen, N. K. Lokanath, and P. A. Suchetan. "A Failed Cocrystallization Attempt Resulted in Novel First Polymorphic Structure: Crystal Structure and Hirshfeld Surface Analysis of the Polymorph of 4-Oxo-4-(pyridin-2-ylamino)butanoic Acid." Asian Journal of Chemistry 35, no. 5 (2023): 1146–52. http://dx.doi.org/10.14233/ajchem.2023.27709.

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An attempt to cocrystallize 4-oxo-4-(pyridin-2-ylamino)butanoic acid (APS) with adipic acid in the ratio 1:1 was made. Solvent assisted grinding followed by solvent evaporation technique using ethanol as solvent yielded single crystals. Single crystal X-ray diffraction (SCXRD) studies of the obtained crystals showed that an attempt to obtain cocrystals has failed and instead has yielded a novel and very first polymorphic structure of APS (1). Compound 1 crystallizes with one molecule in the asymmetric unit in monoclinic P21/n system, whereas, the earlier reported polymorph, 2, crystallizes in

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12

Suneetha, Yerukala, Bommana Naresh Kumar, Yapati Harinath, D. Harikishore Kumar Reddy, and Kalluru Seshaiah. "Functionalization of cross linked chitosan with 2-aminopyridine-3-carboxylic acid for solid phase extraction of cadmium and zinc ions and their determination by atomic absorption spectrometry." Microchimica Acta 176, no. 1-2 (2011): 169–76. http://dx.doi.org/10.1007/s00604-011-0707-z.

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13

Pawlukojć, A., W. Starosta, J. Leciejewicz, I. Natkaniec, and D. Nowak. "The molecular structure and dynamics of 2-aminopyridine-3-carboxylic acid by X-ray diffraction at 100K, inelastic neutron scattering, infrared, Raman spectroscopy and from first principles calculations." Chemical Physics Letters 437, no. 1-3 (2007): 32–37. http://dx.doi.org/10.1016/j.cplett.2007.01.083.

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14

Li, Jian, Xiaojia Wang, and Yunyin Niu. "M-Carboxylic Acid Induced Formation of New Coordination Polymers for Efficient Photocatalytic Degradation of Ciprofloxacin." Molecules 27, no. 22 (2022): 7731. http://dx.doi.org/10.3390/molecules27227731.

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Four new 2–3D materials were designed and synthesized by hydrothermal methods, namely, {[(L1·Cu·2H2O) (4,4-bipy)0.5] (β-Mo8O26)0.5·H2O} (1), {[(L1·Cu)2·(4,4-bipy)] (Mo5O16)} (2), {Co(L1)2}n (3), and {[(L1)2][β-Mo8O26]0.5·5H2O} (4). [L1=5-(4-aminopyridine) isophthalic acid]. The degradation of ciprofloxacin (CIP) in water by compounds 1–4 was studied under visible light. The experimental results show that compounds 1–4 have obvious photocatalytic degradation effect on CIP. In addition, for compound 1, the effects of temperature, pH, and adsorbent dosage on photocatalytic performance were also i

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15

Law, Woon Yi, Mohd Razip Asaruddin, Showkat Ahmad Bhawani, and Samsur Mohamad. "Pharmacophore Modelling of Vanillin Derivatives, Favipiravir, Chloroquine, Hydroxychloroquine, Monolaurin and Tetrodotoxin as MPro inhibitors of Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2)." Applied Cell Biology 9, no. 1 (2021). http://dx.doi.org/10.53043/2320-1991.acb90002.

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Ligand-based pharmacophore modelling approach using four established antiviral drugs, namely remdesivir, lopinavir, ritonavir and hydroxychloroquine were analysed for COVID-19 inhibitors as training sets. Twenty vanillin derivatives together with monolaurin were used as test sets to evaluate potential as SARS-CoV-2 inhibitors. Structure-based pharmacophore modelling approach was also performed using Protein Data Bank information: PDB-5RE6, 5REX and 5RFZ in order to analyse the binding site and ligand-protein complex interactions. The pharmacophore modelling mode of 5RE6 displayed two Hydrogen

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16

Marinus, Tycho, Adam B. Fessler, Craig A. Ogle, and Danny Incarnato. "A novel SHAPE reagent enables the analysis of RNA structure in living cells with unprecedented accuracy." Nucleic Acids Research, January 4, 2021. http://dx.doi.org/10.1093/nar/gkaa1255.

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Abstract Due to the mounting evidence that RNA structure plays a critical role in regulating almost any physiological as well as pathological process, being able to accurately define the folding of RNA molecules within living cells has become a crucial need. We introduce here 2-aminopyridine-3-carboxylic acid imidazolide (2A3), as a general probe for the interrogation of RNA structures in vivo. 2A3 shows moderate improvements with respect to the state-of-the-art selective 2′-hydroxyl acylation analyzed by primer extension (SHAPE) reagent NAI on naked RNA under in vitro conditions, but it signi

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