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Journal articles on the topic '2-Aminothiazole'

Author: Grafiati

Published: 4 June 2021

Last updated: 17 February 2022

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1

Zhang, Xiao Lin, Hong Xia Ouyang, and Yong Hong Ding. "The Synthesis and Characterization of Potential Novel Active Compounds - 2-aminothiazole Derives Schiff Bases." Advanced Materials Research 396-398 (November 2011): 2489–93. http://dx.doi.org/10.4028/www.scientific.net/amr.396-398.2489.

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Some 4-substituted-2-aminothiazoles were prepared starting from aromatic ketones and thiourea in the presence of powered iodine. Then treating 4-substituted-2-aminothiazole with substituted benzaldehyde gave corresponding 2-aminothiazole derives Schiff bases in good yield.

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2

Farouk Elsadek, Mohamed, Badreldin Mohamed Ahmed, and Mohamed Fawzi Farahat. "An Overview on Synthetic 2-Aminothiazole-Based Compounds Associated with Four Biological Activities." Molecules 26, no. 5 (March 7, 2021): 1449. http://dx.doi.org/10.3390/molecules26051449.

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Amongst sulfur- and nitrogen-containing heterocyclic compounds, the 2-aminothiazole scaffold is one of the characteristic structures in drug development as this essential revelation has several biological activities abiding it to act as an anticancer, antioxidant, antimicrobial and anti-inflammatory agent, among other things. Additionally, various 2-aminothiazole-based derivatives as medical drugs have been broadly used to remedy different kinds of diseases with high therapeutic influence, which has led to their wide innovations. Owing to their wide scale of biological activities, their structural variations have produced attention amongst medicinal chemists. The present review highlights the recently synthesized 2-aminothiazole-containing compounds in the last thirteen years (2008–2020). The originality of this proposal is based on the synthetic strategies developed to access the novel 2-aminothiazole derivatives (N-substituted, 3-substituted, 4-substituted, multi-substituted, aryl/alkyl substituents or acyl/other substituents). The literature reports many synthetic pathways of these 2-aminothiazoles associated with four different biological activities (anticancer, antioxidant, antimicrobial and anti-inflammatory activities). It is wished that this review will be accommodating for new views in the expedition for rationalistic designs of 2-aminothiazole-based medical synthetic pathways.

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3

Katritzky, Alan R., Kathleen S. Laurenzo, and Douglas I. Relyea. "The preparation and fungicidal activity of a series of thiazolyl- and isothiazoiyl-diarylcarbinols." Canadian Journal of Chemistry 66, no. 7 (July 1, 1988): 1617–24. http://dx.doi.org/10.1139/v88-262.

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(Isothiazol-5-yl)diarylcarbinols were prepared from 5-lithioisothiazole. (Thiazol-5-yl)diarylcarbinols were obtained via 5-lithio-2-bromothiazole or 5-lithio-2-trimethylsilylthiazole with subsequent removal of the 2-substituent. Corresponding 2-aminothiazol-5-ylcarbinols were made by protecting 2-aminothiazole as its bis(trimethylsilyl) derivative. Biological activities were compared to the calculated electron densities at the heterocyclic N-atoms.

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4

Samadhiya, Pushkal, Ritu Sharma, Santosh Srivastava, and Savitri Srivastava. "Synthesis of 2-oxo-azetidine derivatives of 2-amino thiazole and their biological activity." Journal of the Serbian Chemical Society 77, no. 5 (2012): 599–605. http://dx.doi.org/10.2298/jsc110616002s.

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A new series of N-[2-(2-aminothiazolyl)ethyl]-4-(substitutedphenyl)- 3-chloro-2-oxo-1-iminoazetidine, compounds 4(a-m) have been synthesized from 2-aminothiazole as a starting material. The structure of all the synthesized compounds were confirmed by chemical and spectral analyses such as IR, 1H NMR, 13C NMR and FAB-Mass. All the final synthesized compounds 4(a-m) were screened for their antibacterial and antifungal activities against some selected bacteria and fungi and antitubercular activity screened against M. tuberculosis with their MIC value. Antiinflammatory activity screened against albino rats (either sex) and gave acceptable results.

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5

Toplak, Renata, Nina Lah, Julija Volmajer, Ivan Leban, and Alenka Majcen Le Maréchal. "2-Aminothiazole and 2-aminothiazolinone derivatives." Acta Crystallographica Section C Crystal Structure Communications 59, no. 9 (August 9, 2003): o502—o505. http://dx.doi.org/10.1107/s0108270103015580.

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6

Yeşilel, Okan Zafer, Kamber Akdağb, Hümeyra Paşaoğlu, and Orhan Büyükgüngör. "Synthesis And Spectral, Thermal And Structural Characterization Of A Vitamin B13 Complex Of Nickel(II) With 2-Aminothiazole, Mer-[Ni(HOr)(H2o)2(Ata)2]." Zeitschrift für Naturforschung B 62, no. 6 (June 1, 2007): 818–22. http://dx.doi.org/10.1515/znb-2007-0610.

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The mer-bis(2-aminothiazole)diaqua-orotato-nickel(II) complex, mer-[Ni(HOr)(H2O)2(ata)2] (1), was synthesized and characterized by spectral (IR and UV/vis) and thermal studies. In addition, the crystal structure of the complex was determined by single crystal X-ray diffraction. The complex crystallizes in the triclinic system, space group P1̅. The orotate ligand is coordinated to the nickel(II) atom through a nitrogen atom of the pyrimidine ring and an oxygen atom of the carboxylate group as a bidentate dianion. The coordination of the Ni(II) ion is extended to six by the two 2-aminothiazoles (ata) and two water molecules. The thermal decomposition has been studied in a static air atmosphere

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7

Zav'yalov, S. I., N. E. Kravchenko, G. I. Ezhova, L. B. Kulikova, A. G. Zavozin, and O. V. Dorofeeva. "Synthesis of 2-aminothiazole derivatives." Pharmaceutical Chemistry Journal 41, no. 2 (February 2007): 105–8. http://dx.doi.org/10.1007/s11094-007-0023-4.

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8

Çiftçi, Hakan, Hasan Nur Testereci, and Zeki Öktem. "Electrochemical polymerization of 2-aminothiazole." Polymer Bulletin 66, no. 6 (June 4, 2010): 747–60. http://dx.doi.org/10.1007/s00289-010-0307-9.

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9

Chohan, Zahid H., and Samina Kausar. "Synthesis, Characterization and Biological Properties of Tridentate NNO, NNS and NNN Donor Thiazole-Derived Furanyl, Thiophenyl and Pyrrolyl Schiff Bases and Their Co(II), Cu(II), Ni(II) and Zn(II) Metal Chelates." Metal-Based Drugs 7, no. 1 (January 1, 2000): 17–22. http://dx.doi.org/10.1155/mbd.2000.17.

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2-Aminothiazole undergoes condensation reactions with furane-, thiophene- and pyrrole-2-carboxylaldehyde to give tridentate NNO, NNS and NNN Schiff bases respectively. These tridentate Schiff bases formed complexes of the type [M (L)2]X2 where [M=Co(II), Cu(II), Ni(II) or Zn(II), L=N-(2-furanylmethylene)-2-aminothiazole (L1), N-(2-thiophenylmethylene)-2-aminothiazole (L2), N-(2-pyrrolylmethylene)-2-aminothiazole (L3) and X=Cl. The structures of these Schiff bases and of their complexes have been determined on the basis of their physical, analytical and spectral data. The screening results of these compounds indicated them to possess excellent antibacterial activity against tested pathogenic bacterial organisms e.g., Escherichia coli, Staphylococcus aureous and Pseudomonas aeruginosa. However, in comparison, their metal chelates have been shown to possess more antibacterial activity than the uncomplexed Schiff bases.

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10

Arenas, Juan F., Jesús Perez-Peña, and Melchor Gonzalez-Davila. "Vibrational spectra and thermodynamic properties of thiazole, 2-aminothiazole, 2-amino-[2H]-thiazole and 2-amino-[2H2]-thiazole." Collection of Czechoslovak Chemical Communications 54, no. 1 (1989): 28–41. http://dx.doi.org/10.1135/cccc19890028.

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Infrared and Raman spectra of thiazole have been reinvestigated with new assignments of overtone and combination bands being proposed. Infrared spectra in the solid phase and in different solutions for 2-aminothiazole and 2-amino-[2H2]-thiazole, as well as Raman spectrum of microcrystalline powder for 2-aminothiazole were also studied and a general assignment for all the observed bands have been proposed. The present assignment satisfies the isotopic product rule for i.r. fundamentals. On this basis thermodynamic functions have been computed.

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11

Kim, Chong-Hyeak, and Inn Hoe Kim. "Tetrakis(2-aminothiazole-κN3)dichloridocadmium(II)." Acta Crystallographica Section E Structure Reports Online 66, no. 1 (December 4, 2009): m13. http://dx.doi.org/10.1107/s1600536809051770.

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12

Lynch, Daniel E., and Ian McClenaghan. "Diethyl 2-aminothiazole-4,5-dicarboxylate hemihydrate." Acta Crystallographica Section E Structure Reports Online 61, no. 4 (March 4, 2005): o824—o826. http://dx.doi.org/10.1107/s1600536805006197.

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13

Abdulhadi, Shayma L., Maadh Q. Abdulkadir, and May M. Al-Mudhafar. "The Importance of 2-AminoThiazole Schiff Bases as Antimicrobial and Anticancer Agents." Al-Mustansiriyah Journal of Science 31, no. 3 (August 20, 2020): 46. http://dx.doi.org/10.23851/mjs.v31i3.865.

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The pharmacophore 2-aminothiazole has an interesting role in pharmaceutical chemistry as this led to the synthesis of many types of compounds with diverse biological activity. Schiff base derivatives at the same time contribute to drug evolution importantly. In this review, the Schiff base derivatives of 2-aminothiazole formed and some of their metal complexes are being focused on, and the antimicrobial and anticancer activity of them is being illustrated.

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14

Macíček, J., and K. Davarski. "Structure of bis(2-aminothiazole)dichlorozinc(II)." Acta Crystallographica Section C Crystal Structure Communications 49, no. 3 (March 15, 1993): 592–93. http://dx.doi.org/10.1107/s0108270192010382.

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15

Lynch, Daniel E., Laura J. Nicholls, Graham Smith, Karl A. Byriel, and Colin H. L. Kennard. "Molecular co-crystals of 2-aminothiazole derivatives." Acta Crystallographica Section B Structural Science 55, no. 5 (October 1, 1999): 758–66. http://dx.doi.org/10.1107/s0108768199003146.

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A series of molecular adducts of 2-aminothiazole derivatives – 2-aminothiazole, 2-amino-2-thiazoline and 2-aminobenzothiazole with the carboxylic-acid-substituted heterocyclics indole-2-carboxylic acid, N-methylpyrrole-2-carboxylic acid and thiophene-2-carboxylic acid – have been prepared and characterized using X-ray powder diffraction and in five cases by single-crystal X-ray diffraction methods. These five compounds are the adducts of 2-amino-2-thiazolium with indole-2-carboxylate [(C3H7N2S)+(C9H6NO2)−], and N-methylpyrrole-2-carboxylate [(C3H7N2S)+-(C6H6NO2)−], 2-aminobenzothiazolium with indole-2-carboxylate [(C7H7N2S)+(C9H6NO2)−], N-methylpyrrole-2-carboxylate [(C7H7N2S)+(C6H6NO2)−] and thiophene-2-carboxylate [(C7H7N2S)+(C5H3O2S)−]. All complexes involve proton transfer, as indicated by IR spectroscopy, while the five crystal structures display similar hydrogen-bonding patterns with the dominant interaction being an R^2_2(8) graph set dimer association between carboxylate groups and the amine/heterocyclic nitrogen sites. Futhermore, in each case a subsiduary interaction between an amino proton and a carboxylate oxygen completes a linear hydrogen-bonded chain. In addition to this, the indole-2-carboxylate molecules in the adduct structure with 2-amino-2-thiazolium form associated dimers which add to the hydrogen-bonding network.

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16

Zav'yalov, S. I., O. V. Dorofeeva, E. E. Rumyantseva, L. B. Kulikova, G. I. Ezhova, N. E. Kravchenko, and A. G. Zavozin. "ChemInform Abstract: Synthesis of 2-Aminothiazole Derivatives." ChemInform 32, no. 47 (May 23, 2010): no. http://dx.doi.org/10.1002/chin.200147105.

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17

Zhang, Lai-Jun, Xing-Can Shen, Yan Yang, and Hong Liang. "Bis(2-aminothiazole-4-acetato)aquazinc(II)." Acta Crystallographica Section E Structure Reports Online 65, no. 12 (November 4, 2009): m1517. http://dx.doi.org/10.1107/s1600536809045589.

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18

Chafi, N., J. P. Monthéard, and J. M. Vergnaud. "Release of 2-aminothiazole from polymer carriers." International Journal of Pharmaceutics 67, no. 3 (January 1991): 265–74. http://dx.doi.org/10.1016/0378-5173(91)90209-7.

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19

Zou, Hua, and Zhe Wang. "Poly(2-aminothiazole): An emerging functional polymer." Progress in Organic Coatings 158 (September 2021): 106345. http://dx.doi.org/10.1016/j.porgcoat.2021.106345.

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20

Farzaliyev, V. M., M. T. Abbasova, B. G. Babaeva, M. A. Mirzoeva, G. M. Kulieva, L. R. Safarova, and N. A. Alieva. "N-ALKOXYMETHYL DERIVATIVES OF 2-AMINOTHIAZOLE AND THEIR PROTECTIVE PROPERTIES." Chemical Problems 18, no. 4 (2020): 427–35. http://dx.doi.org/10.32737/2221-8688-2020-4-427-435.

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Conditions for alkoxymethylation of 2-aminothiazole with semiformals obtained by the interaction of aliphatic alcohols with formaldehyde were worked out. Alkoxymethylation was performed by means of preliminary preparation of the semiformal of appropriate hydroxylcontaining compounds followed by interaction of semiformal with equimolar amount of 2- aminothiazole. The structure of the obtained compounds was acknowledged by means of IR and NMR 1 H spectroscopy. It was established that the reaction of the alkoxymethylation proceeds in the amino form of the starting 2-aminothiazole to form an appropriate monosubstituted Nalkoxymethyl derivative. As a result of microbiological tests, it was established that these compounds have high bactericidal properties against microorganisms which affect petroleum products and, at a concentration of 0.5%, completely protect both M-8 lubricating oil and diesel fuel from damage by bacteria even in terms of their forced infection. It found that at a concentration of 100 mg/l the obtained compounds protect the CT-3 steel from acid corrosion, moreover N-(isopropoxymethyl)thiazol-2-amine has the greatest protection effect.

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21

Alexandru, Maria-Gabriela, Tanja Velickovic, Ioana Jitaru, Sanja Grguric-Sipka, and Constantin Draghici. "Synthesis, characterization and antitumor activity of Cu(II), Co(II), Zn(II) and Mn(II) complex compounds with aminothiazole acetate derivative." Open Chemistry 8, no. 3 (June 1, 2010): 639–45. http://dx.doi.org/10.2478/s11532-010-0022-2.

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AbstractThis paper presents the synthesis of complex compounds of type [M(L1)2], where M(II)= Cu (1), Co (2), Zn (3), L1=2-aminothiazole-4-acetate and [Mn(L1)2(H2O)] (4) using ethyl 2-(2-aminothiazole-4-yl) acetate (L), and characterization by elemental analysis, magnetic susceptibilities, IR, 1H-NMR, UV-Vis spectroscopy and for [Mn(L1)2(H2O)] also by X-ray diffraction. In vitro cytotoxicity studies were performed on human cervix adenocarcinoma, HeLa cells. The antitumor selectivity was assessed using normal human peripheral blood mononuclear cells, PBMC as control.

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22

Canestrari, Stefania, Paolo Sgarabotto, Aldo Andreani, and Lucedio Greci. "New Insights on the Reaction of 2-Aminothiazole with Ethyl Bromopyruvate for the Synthesis of 6-Ethoxycarbonylimidazothiazole. Crystal Structure of 5-Acetyl-6-ethoxycarbonylimidazo-[2,1-b]thiazole and 2-Ethoxycarbonyl-2-hydroxy-7-oxo-thiazole[2,3-b]pyrimido[2,3-d]furan." Journal of Chemical Research 23, no. 7 (July 1999): 412–13. http://dx.doi.org/10.1177/174751989902300704.

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23

Hussein, Abdel Haleem M., Ahmed A. Khames, Abu-Bakr A. El-Adasy, Ahmed A. Atalla, Mohamed Abdel-Rady, Mohamed I. A. Hassan, Mohamed T. M. Nemr, and Yaseen A. A. M. Elshaier. "Design, synthesis and biological evaluation of new 2-aminothiazole scaffolds as phosphodiesterase type 5 regulators and COX-1/COX-2 inhibitors." RSC Advances 10, no. 50 (2020): 29723–36. http://dx.doi.org/10.1039/d0ra05561a.

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24

Lv, Peng Fei, Xia Wang, and Hua Zou. "Chemical Synthesis and Characterization of Conducting Poly(2-Aminothiazole)." Materials Science Forum 867 (August 2016): 111–15. http://dx.doi.org/10.4028/www.scientific.net/msf.867.111.

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In this work, poly(2-aminothiazole) (P2AT) was synthesized by chemical oxidation method using 2-aminothiazole as the monomer. The polymerization was initiated using three different oxidants, CuCl2, FeCl3 and (NH4)2S2O8. The results suggested that the monomer was easily polymerized and higher yields were achieved when CuCl2 was used as the oxidant. The effects of reaction time and polymerization temperature on the yield of polymerization using CuCl2 were investigated. The polymerization yield of the P2ATs was 25.2 % at oxidant/monomer molar ratio of 0.1 for 24 h in the copper chloride /deionized water. The P2ATs were characterized by FT-IR, UV-vis, thermogravimetric analysis (TGA) and scanning electron microscopy (SEM).

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25

Li, Minghua, Yoo-Jin Sim, and Seung-Wook Ham. "Discovery of 2-Aminothiazole Derivatives as Antitumor Agents." Bulletin of the Korean Chemical Society 31, no. 6 (June 20, 2010): 1463–64. http://dx.doi.org/10.5012/bkcs.2010.31.6.1463.

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26

Solmaz, Ramazan, and Gülfeza Kardaş. "Electrochemical synthesis and characterization of poly-2-aminothiazole." Progress in Organic Coatings 64, no. 1 (January 2009): 81–88. http://dx.doi.org/10.1016/j.porgcoat.2008.07.010.

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27

Zhang, Ao, Wennan Xiong, James E. Hilbert, Emily K. DeVita, Jean M. Bidlack, and John L. Neumeyer. "2-Aminothiazole-Derived Opioids. Bioisosteric Replacement of Phenols." Journal of Medicinal Chemistry 47, no. 8 (April 2004): 1886–88. http://dx.doi.org/10.1021/jm049978n.

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28

Choi, Minho, Sun-Woo Won, Hyeju Jo, Mayavan Viji, Seung-Yong Seo, Yeon-Ju Lee, Hyi-Seung Lee, et al. "A novel and efficient amidation of 2-aminothiazole." Tetrahedron Letters 55, no. 48 (November 2014): 6582–84. http://dx.doi.org/10.1016/j.tetlet.2014.10.031.

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29

Kuz'mina, L. G., and Yu T. Struchkov. "Crystal and molecular structure of 2-aminothiazole trichloroacetate." Journal of Structural Chemistry 25, no. 6 (1985): 917–20. http://dx.doi.org/10.1007/bf00747835.

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30

Singh, B., and Praveen K. Singh. "Molecular structure of lanthanide complexes of 2-aminothiazole." Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 52, no. 6 (June 1996): 705–6. http://dx.doi.org/10.1016/0584-8539(95)01613-9.

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31

Wang, Xuemei, Feng Xu, Qingge Xu, Hossen Mahmud, Jonathan Houze, Liusheng Zhu, Michelle Akerman, et al. "Optimization of 2-aminothiazole derivatives as CCR4 antagonists." Bioorganic & Medicinal Chemistry Letters 16, no. 10 (May 2006): 2800–2803. http://dx.doi.org/10.1016/j.bmcl.2006.01.126.

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32

Liebscher, Jürgen, and Horst Hartmann. "Eine neue Variante zur Synthese substituierter 2-Aminothiazole." Zeitschrift für Chemie 14, no. 12 (September 1, 2010): 470–71. http://dx.doi.org/10.1002/zfch.19740141206.

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33

Özbek, Oguz, and Meliha Burcu Gürdere. "Synthesis and anticancer properties of 2-aminothiazole derivatives." Phosphorus, Sulfur, and Silicon and the Related Elements 196, no. 5 (January 17, 2021): 444–54. http://dx.doi.org/10.1080/10426507.2020.1871347.

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34

Gondi, Sudershan R., and David Y. Son. "Synthesis of (Hetaryl)alkylamines from the Reactions of 2‐Aminopyrimidine, 2‐Aminothiazole, and 2‐Aminothiazoline with Benzyl Bromide and Xylylene Dibromides." Synthetic Communications 38, no. 3 (January 1, 2008): 401–10. http://dx.doi.org/10.1080/00397910701771074.

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35

Chugunova, Elena, Gabriele Micheletti, Dario Telese, Carla Boga, Daut Islamov, Konstantin Usachev, Alexander Burilov, et al. "Novel Hybrid Compounds Containing Benzofuroxan and Aminothiazole Scaffolds: Synthesis and Evaluation of Their Anticancer Activity." International Journal of Molecular Sciences 22, no. 14 (July 13, 2021): 7497. http://dx.doi.org/10.3390/ijms22147497.

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A series of novel hybrid compounds containing benzofuroxan and 2-aminothiazole moieties are synthesized via aromatic nucleophilic substitution reaction. Possible reaction pathways have been considered quantum-chemically, which allowed us to suggest the most probable products. The quantum chemical results have been proved by X-ray data on one compound belonging to the synthesized series. It was shown that the introduction of substituents to both the thiazole and amine moieties of the compounds under study strongly influences their UV/Vis spectra. Initial substances and obtained hybrid compounds have been tested in vitro as anticancer agents. Target compounds showed selectivity towards M-HeLa tumor cell lines and were found to be more active than starting benzofuroxan and aminothiazoles. Furthermore, they are considerably less toxic to normal liver cells compared to Tamoxifen. The mechanism of action of the studied compounds can be associated with the induction of apoptosis, which proceeds along the mitochondrial pathway. Thus, new hybrids of benzofuroxan are promising candidates for further development as anticancer agents.

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36

Dương, Công-Thắng, and Xuan Thi Thi Luu. "The ultrasound accelerated solvent-free synthesis of ethyl 7-methyl-5-phenyl-5H-thiazolo[3,2-a]pyrimidine-6-carboxylate through Biginelli reaction catalyzed by Amberlyst-15." Science and Technology Development Journal - Natural Sciences 4, no. 3 (August 24, 2020): First. http://dx.doi.org/10.32508/stdjns.v4i3.868.

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Multi-component reactions (MCRs) played an important role to produce complex molecular structures in a one-step process. Among all MCRs reported, Biginelli reaction was one of the most well-known and used in organic synthesis to constitute pyrimidine scaffolds. Therefore, a solvent-free Biginelli reaction of 2-aminothiazole, benzaldehyde and ethyl acetoacetate catalyzed by Amberlyst-15 (A-15) had attracted us to pay attention and to do research in order to highly obtain a desired product, a frame of thiazolo[3,2-a]pyrimidine being present in many active biological compounds. Amberlyst-15, polystyrene resin regarded as a green acidic solid, available commercial, inexpensive and reusable catalyst had been firstly and successfully developed for solvent-free Biginelli reaction under ultrasound irradiation to form thiazolo[3,2-a]pyrimidine. Most factors which had influenced on the reaction conversion and yield such as the molar ratios between 2-aminothiazole, benzaldehyde and ethyl acetoacetate, the amounts of catalyst A-15, and reaction time had been investigated. Consequently, the yield of ethyl 7-methyl-5-phenyl-5H-thiazolo[3,2-a]pyrimidine-6-carboxylate had been also found to depend on the amount of the acidic solid catalyst and little excess amounts of the two reactants, e.g. 2-aminothiazole and ethyl acetoacetate. The maximum yield has been obtained 76% after six-hour ultrasound irradiation at 80oC with the molar ratio of 2-aminothiazole : benzaldehyde : ethyl acetoacetate (1.4:1.0:1.4) and 50 mg of catalyst A-15. The results showed that Amberlyst-15 had high capability of recovery and recycling owing to the inconsiderably changes of product yields after two recycle runs.

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37

Olaru, Alexandra M., Soumya S. Roy, Lyrelle S. Lloyd, Steven Coombes, Gary G. R. Green, and Simon B. Duckett. "Creating a hyperpolarised pseudo singlet state through polarisation transfer from parahydrogen under SABRE." Chemical Communications 52, no. 50 (2016): 7842–45. http://dx.doi.org/10.1039/c6cc02020h.

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38

Kakati, Praachi, Preeti Singh, Priyanka Yadav, and Satish Kumar Awasthi. "Aiding the versatility of simple ammonium ionic liquids by the synthesis of bioactive 1,2,3,4-tetrahydropyrimidine, 2-aminothiazole and quinazolinone derivatives." New Journal of Chemistry 45, no. 15 (2021): 6724–38. http://dx.doi.org/10.1039/d1nj00280e.

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39

Saad, Ali, Youssef Snoussi, Manef Abderrabba, and Mohamed M. Chehimi. "Ligand-modified mesoporous silica SBA-15/silver hybrids for the catalyzed reduction of methylene blue." RSC Advances 6, no. 62 (2016): 57672–82. http://dx.doi.org/10.1039/c6ra12061j.

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40

Rasheed, Tahir, Chuanlong Li, Faran Nabeel, Meiwei Qi, Yinglin Zhang, and Chunyang Yu. "Real-time probing of mercury using an efficient “turn-on” strategy with potential as in-field mapping kit and in live cell imaging." New Journal of Chemistry 42, no. 13 (2018): 10940–46. http://dx.doi.org/10.1039/c8nj01746h.

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41

Khalifa, Mohamed Ezzat. "Recent Developments and Biological Activities of 2-Aminothiazole Derivatives." Acta Chimica Slovenica 65, no. 1 (March 20, 2018): 1–22. http://dx.doi.org/10.17344/acsi.2017.3547.

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42

Manju, P. Joshi, and D. Kumar. "Metal complexes of biological active 2-aminothiazole derived ligands." Russian Journal of Coordination Chemistry 40, no. 7 (June 28, 2014): 445–59. http://dx.doi.org/10.1134/s1070328414070069.

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43

Zhao, Rulin, Stacey Gove, Joseph E. Sundeen, and Bang-Chi Chen. "A new facile synthesis of 2-aminothiazole-5-carboxylates." Tetrahedron Letters 42, no. 11 (March 2001): 2101–2. http://dx.doi.org/10.1016/s0040-4039(01)00161-7.

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44

Sargsyan, S. H., and K. S. Margaryan. "Metal-containing polymer coatings based on poly(2-aminothiazole)." Russian Journal of General Chemistry 84, no. 6 (June 2014): 1190–92. http://dx.doi.org/10.1134/s1070363214060218.

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Manju, P. Joshi, and D. Kumar. "Metal Complexes of Biological Active 2-Aminothiazole Derived Ligands." Координационная химия 40, no. 7 (2014): 387–401. http://dx.doi.org/10.7868/s0132344x14070068.

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46

Nikolova, Antonina, Darvin Ivanov, Panayot Bontchev, Rossen Buyukliev, Dimitar Mehandjiev, Georgi Gochev, Spiro Konstantinov, and Margarita Karaivanova. "Complexes of Ruthenium (III) with Some 2-Aminothiazole Derivatives." Arzneimittelforschung 54, no. 06 (December 25, 2011): 323–29. http://dx.doi.org/10.1055/s-0031-1296979.

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47

Papadopoulou, Maria V., William D. Bloomer, Howard S. Rosenzweig, Shane R. Wilkinson, Joanna Szular, and Marcel Kaiser. "Antitrypanosomal activity of 5-nitro-2-aminothiazole-based compounds." European Journal of Medicinal Chemistry 117 (July 2016): 179–86. http://dx.doi.org/10.1016/j.ejmech.2016.04.010.

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48

Pi, Zulan, James Sutton, John Lloyd, Ji Hua, Laura Price, Qimin Wu, Ming Chang, et al. "2-Aminothiazole based P2Y1 antagonists as novel antiplatelet agents." Bioorganic & Medicinal Chemistry Letters 23, no. 14 (July 2013): 4206–9. http://dx.doi.org/10.1016/j.bmcl.2013.05.025.

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49

Kadam, Shuddhodan N., Ajay N. Ambhore, Rahul D. Kamble, Mahesh G. Wakhradkar, Priya D. Gavhane, Milind V. Gaikwad, Krishna Chaitanya Gunturu, and Bhaskar S. Dawane. "Metal-free efficient thiolation of C(sp2) functionalization via in situ-generated NHTS for the synthesis of novel sulfenylated 2-aminothiazole and imidazothiazole." New Journal of Chemistry 45, no. 10 (2021): 4632–37. http://dx.doi.org/10.1039/d0nj05904h.

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Abstract:

A direct metal-free approach for the synthesis of novel sulfenylated 2-aminothiazole and imidazothiazole derivatives at room temperature is reported via an in situ-generated electrophilic thiolating agent.

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50

Merniz, Salah, Louiza Himed, Mahieddine Mokhtari, and Abdelhamid Mousser. "Marquage du 2-aminothiazole avec une unité cyclohexadiène fer tricabonyle. Étude structurale et activité antibactérienne du complexe marqué (1-4-η-5-N-2-aminothiazoliocyclohexa-1,3-diène) fer tricarbonyle." Canadian Journal of Chemistry 97, no. 10 (October 2019): 704–10. http://dx.doi.org/10.1139/cjc-2019-0016.

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Abstract:

La réaction du 2-aminothiazole (C3H4N2S) avec le complexe tétrafluoroborate de (1-4-η-5-N-pyridiniocyclohexa-1,3-diène) fer tricarbonyle [C11H12NFe(CO)3]+[BF4]− (1), précurseur du cation marqueur [(1-5-η-C6H7)Fe(CO)3]+ donne un nouveau complexe de formule C9H10N2SFe(CO)3, le (1-4-η-5-N-2-aminothiazolocyclohexa-1,3-diène) fer tricarbonyle (2). La structure de ce complexe a été caractérisée par les méthodes spectroscopiques IR et RMN 1H suivies d’une étude structurale par diffraction des rayons X, qui a montré que le complexe marqué 2 adopte stéréosélectivement une configuration exo. Dans l’édifice cristallin, les composants de la structure sont liés par des liaisons hydrogènes intermoléculaires de type N–H⋯N formant des chaînes dimériques le long de l’axe b. L’évaluation de l’activité antimicrobienne du ligand libre 2-aminothiazole a montré une activité antibactérienne importante. Après sa complexation par le marqueur organo fer tricarbonyle, cette activité a augmenté.

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