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Dissertations / Theses on the topic '2-aryl-2'

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Published: 4 June 2021

Last updated: 26 July 2025

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1

White, David Charles. "Synthesis of 3-Aryl-2-(2-aryl-2-oxoethyl)pyrido[2,3-d]-4(3H)pyrimidones and 3-Aryl-2-(2-arylethenyl)pyrido[2,3-d]-4(3H)pyrimidones as Potential Antiepileptic Drugs." Thesis, Virginia Tech, 1997. http://hdl.handle.net/10919/46506.

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A series of 2-alkyl-3-arylpyrido[2,3-d]pyrimidones were synthesized for testing as potential antiepileptic drugs. The goal was to achieve better neurological activity and/or lower toxicity than displayed by a series of 2-alkyl-3-aryl-4(3H)-quinazolinones prepared previously in our research group. From the pharmacological testing data of these target compounds, we have found that the additional nitrogen at the C-8 position of the quinazolinone framework increased the anticonvulsant activity. However, the neurological toxicity increased as well. The anticonvulsant and neurotoxic activi

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2

Fuglseth, Erik. "Synthesis of 1-aryl-2-fluoroethanones and their use in the preparation of enantioenriched 1-aryl-2-fluoroethanols and 1-aryl-2-fluoroethylamines." Doctoral thesis, Norges teknisk-naturvitenskapelige universitet, Institutt for kjemi, 2010. http://urn.kb.se/resolve?urn=urn:nbn:no:ntnu:diva-11631.

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3

Tembo, Norbert Olivier. "Synthèse et étude physicochimique des 4-amino-1, 2, 3, 4-tétrahydro-1-isoquinolones et 2-quinolones ; 4-aryl-2, 3-dihydropyrrolizines ; 4-aryl-1-oxo-1, 2, 3, 4-tétrahydro-pyrrolo [1, 2-a] pyrazines ; 4-aryl-2-imidazolidinones." Caen, 1990. http://www.theses.fr/1990CAEN4044.

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4

Stoddart, Barry. "The structural and spectroscopic characterisation of 2-aryl and 2-heteroaryl isatogens." Thesis, University of Sunderland, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.258718.

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This work reviews the current knowledge of the synthesis , properties , structures and biological activities of isatogens. The unequivocal 2 C NMR assignment of 2-phenylisatogen 1S reported and used to assign the spectra for a range of 2-(4-substituted-phenyl)isatogens. Molecular dynamics of 2-phenylisatogen in chloroform are reported and indicate that there is little if any inter-ring mesomeric resonance in this compound. 1~C , ~N NMR and UV-Visible spectroscopic data are reported for a range of 2-(4-substituted-phenyl)isatogens. Analysis of this data indicates a small but significant degree

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5

Cui, Xiuhua. "Asymmetric hydrogenations of aryl alkenes using imidazol-2-ylidene iridium complexes." Texas A&M University, 2005. http://hdl.handle.net/1969.1/2456.

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A library of iridium complexes featuring oxazoline and imidazol-2-ylidene ligands were synthesized by reaction of a library of imidazoles with a second library of oxazoline iodides. These complexes were active catalysts for hydrogenations of aryl substituted monoenes. Tri- and 1,1-disubstituted alkenes were hydrogenated quantitatively with ee??s up to 99% at 1 atm hydrogen pressure. Catalyst, substrate, temperature and pressure effects were studied. The iridium complexes were also used for the kinetic study of hydrogenation of 2,3- diphenylbutadiene. This hydrogenation is a stepwise reaction:

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6

Hassan, Ahmad. "Etude analytique de quelques anti-inflammatoires non stéroi͏̈diens aryl 2 propioniques." Bordeaux 2, 1990. http://www.theses.fr/1990BOR2B001.

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7

Sheridan, Jared. "Partnership between the aryl hydrocarbon receptor (AHR) and RELB regulates cigarette smoke-induced cyclooxygenase-2 (COX-2) expression." Thesis, McGill University, 2014. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=123307.

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Chronic obstructive pulmonary disease (COPD) is an inflammatory disease of the lungs caused by cigarette smoke exposure; COPD is also now the third leading cause of death worldwide. Controlling lung inflammation is a priority in COPD patients, but currently-available medications offer little relief. Thus, new therapeutic targets represent a major unmet need. Previously, the aryl hydrocarbon receptor (AHR) has been shown to suppress cigarette smoke-induced inflammation. The AHR is a ligand-activated transcription factor, and well-established for its response to xenobiotic ligands. AHR-mediated

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8

BRINE, NOURDINE. "Etude de la catalyse par des halogenures metalliques supportes sur silica gel, de l'ouverture des 3-aryl-2-cyano-2-methoxycarbonyloxiranes et de l'alkylation par les phenols des 3-aryl-3-hydroxy-2-methylenepropionates de methyle." Rennes 1, 1993. http://www.theses.fr/1993REN10065.

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Ce memoire etudie la modification de la reactivite d'un halogenure metallique (fecl#3, znbr#2, cucl#2, cubr#2, cocl#2) par depot sur le silica gel. Cette reactivite est determinee en utilisant ces halogenures metalliques comme catalyseurs de deux types de reactions: l'ouverture du cycle des 3-aryl-2-cyano-2-methoxycarbonyl oxiranes et l'alkylation des phenols par les 3-aryl-3-hydroxy-2-methylene propionates de methyle. Dans la premiere partie on decrit la transformation des epoxydes en cyanhydrines chlorees par fecl#3/sio#2 et en alpha-ceto esters beta-halogenes par cocl#2/sio#2 ou znbr#2/sio#

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9

Guan, Zong [Verfasser]. "Eigenschaften und Reaktionen von 2-Alkyl-1-aryl-1H-Indazolcarbenen / Zong Guan." Clausthal-Zellerfeld : Universitätsbibliothek Clausthal, 2015. http://d-nb.info/1078276927/34.

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10

Soraci, Alejandro L. "Métabolisation stéréosélective comparée des acides aryl-2-propioniques : inversion chirale et glucuronoconjugaison." Lyon 1, 1995. http://www.theses.fr/1995LYO1T073.

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11

Khan, Imtiaz. "Enolate-directed catalytic C-H functionalization of 2-aryl-1,3-dicarbonyl compounds." Thesis, University of Nottingham, 2015. http://eprints.nottingham.ac.uk/30261/.

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I) Synthesis of Spiroindenes by Enolate-Directed Ruthenium-Catalyzed Oxidative Annulation of Alkynes with 2-Aryl-1,3-dicarbonyl Compounds The synthesis of carbocycles by the ruthenium-catalyzed oxidative annulation of alkynes with 2-aryl cyclic 1,3-dicarbonyl substrates is described. Proceeding by the functionalization of C(sp3)–H and C(sp2)–H bonds, and the formation of all-carbon quaternary centers, the reactions provide a diverse range of spiroindenes in good yields and high levels of regioselectivity. II) Synthesis of Benzopyrans by Pd(II)- or Ru(II)-Catalyzed C–H Alkenylation of 2-Aryl-3-

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12

Fiorucci, Sandrine. "Caractérisation cellulaire et moléculaire de l'activité de dérivés de 2-aryl-3-quinolone, une famille de petites molécules antagonistes de la queue cytoplasmique des intégrines." Thesis, Grenoble, 2013. http://www.theses.fr/2013GRENV058/document.

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Les flavonoïdes sont étudiés depuis des années pour leurs propriétés préventives et leur potentiel comme agents thérapeutiques. Plusieurs mécanismes pourraient intervenir dans leur activité anti-cancéreuse dont une inhibition de l'adhérence et de l'étalement cellulaire et une inhibition des propriétés invasives des cellules cancéreuses. Les dérivés de 3-aryl-2-quinolones sont structurellement proches des flavonoïdes et ont été caractérisés comme étant des composés anti-migratoires (Joseph et Al., J.Med.Chem, 2002). Comme la migration cellulaire est hautement dépendante des structures adhésives

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13

Panasenko, N. V., and М. K. Bratenko. "Synthesis of 3-(3-aryl-1-phenyl-1H-4-pyrazolil)-chromen-2-ones." Thesis, БДМУ, 2017. http://dspace.bsmu.edu.ua:8080/xmlui/handle/123456789/16864.

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14

Hopper, Allen T. "Synthesis of optically pure 4-aryl-2-hydroxytetronic acids : stereogenically labile aci-reductones /." The Ohio State University, 1993. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487848078448695.

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15

Xiao, Kefeng. "Microwave Assisted Synthesis and GABAA Receptor Modulation of 2-Aryl-4(1H)-quinolones." Thesis, The University of Sydney, 2010. https://hdl.handle.net/2123/29218.

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y-Aminobutyric acid (GABA) is the most important inhibitory neurotransmitter in the mammalian central nervous system. GABA is involved in all functions of the central nervous system (CNS), as well as in many disease states. Allosteric modulators of GABA can modify the action of GABA at GABA receptors. Therefore the study of allosteric GABA receptor modulators is of significant interest in drug discovery. Flavonoids have been previously reported as modulators of GABA receptor function. The aim of this project is to develop a microwave-assisted synthetic route to 2-ary1-4(1H)—quinolones w

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16

Jones, Carrie Preston. "Development of a copper-catalyzed amidation-base-promoted cyclization sequence for the synthesis of 2-aryl- and 2-vinyl1-4 quinolones." Thesis, Massachusetts Institute of Technology, 2007. http://hdl.handle.net/1721.1/41771.

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Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Chemistry, 2007.<br>Vita.<br>Includes bibliographical references (p. 45-48).<br>A direct two-step method for the preparation of 2-aryl- and 2-vinyl-4-quinolones that utilizes a copper-catalyzed amidation of ortho-halophenones followed by a base-promoted Camps cyclization of the resulting N-(2-keto-aryl)amides is described. With Cul, a diamine ligand, and base as the catalyst system, the amidation reactions proceed in good yields for a range of aryl, heteroaryl, and vinyl amides. The subsequent Camps cyclization efficiently provides

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17

Toyoshima, Takeharu. "Synthesis of Oxindoles by Palladium Catalyzed Cyclization Reactions of 2-(Alkynyl)aryl Isocyanates with Nucleophiles." 京都大学 (Kyoto University), 2011. http://hdl.handle.net/2433/142568.

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18

Angulo-Escalante, Miguel Angel 1962. "Inhibition of thioredoxin signalling by alkyl and aryl 2-imidazolyl disulfide compounds as potential antitumor agents." Diss., The University of Arizona, 1998. http://hdl.handle.net/10150/282694.

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This work describes (1) the identification of alkyl and aryl 2-imidazolyl disulfides that inhibit growth in human cancer cell lines, (2) examines the antitumor activities of these disulfides in xenografted scid mice, (3) characterizes the chemopreventive activity in min mice of the disulfides IV-2, and (4) suggests the potential mechanisms by which these compounds mediate their actions. The alkyl and aryl 2-imidazolyl disulfides are inhibitors of the TR/Trx which regulates cell growth in both normal and cancer cells and is constitutively activated in a number of human primary cancers (Berggren

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19

BRODIN, ROGER. "Derives acyles de 2-amino-4-aryl thiazoles, ligands non peptidiques des recepteurs de la cholecystokinine." Strasbourg 1, 1996. http://www.theses.fr/1996STR15099.

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20

Ross, Tobias Ludwig. "Direct no-carrier-added 18F-labelling of arenes via nucleophilic substitution on aryl(2-thienyl)iodonium salts." [S.l.] : [s.n.], 2005. http://deposit.ddb.de/cgi-bin/dokserv?idn=979216419.

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21

Bolduc, Sébastien. "Effets sur la mitochondrie d'une nouvelle classe d'agents alkylants doux, les 1-aryl-3-(2-chloroéthyle)urées." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape2/PQDD_0021/MQ56392.pdf.

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22

Schmidt, Michael Joseph. "A New Late-Stage Lawesson's Cyclization Strategy Towards the Synthesis of Aryl 1,3,4-Thiadiazole-2-Carboxylate Esters." Kent State University Honors College / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=ksuhonors1373911614.

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23

Bob-Egbe, Opetoritse. "Development of axially chiral 2-aryl-4-dialkylaminopyridine-N-oxide based catalysts for the sulfonylative kinetic resolution of amines." Thesis, Imperial College London, 2012. http://hdl.handle.net/10044/1/9776.

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Lewis base catalysis has been studied extensively in recent years as a powerful tool for introducing asymmetry into a variety of reactions, avoiding the use of expensive and potentially toxic metal catalysts. There is however still ample scope for the development of procedures for the non-enzymatic catalytic kinetic resolution (KR) of amines. Unlike alcohols, the intrinsic high reactivity of amines towards acyl and sulfonyl donors makes their KR highly challenging. As a result, there are relatively few publications on non-enzymatic catalytic KR of amines via acylation1-8 and none via sulfonyla

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24

Pocinho, Alexandre. "Conception de dérivés 2-aryl-benzothiazoles pour la reconnaissance d'agrégats du peptide amyloïde-β par diverses approches physico-chimiques". Thesis, Toulouse 3, 2018. http://www.theses.fr/2018TOU30125/document.

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La maladie d'Alzheimer (MA) est une maladie neurodégénérative qui est la cause la plus fréquente de démence chez les personnes âgées. Il est proposé que celle-ci ait pour origine l'agrégation du peptide l'amyloïde-ß (Aß) qui, produit à l'état monomérique, est retrouvé sous formes de plaques séniles dans le cerveau des patients. Lors de l'agrégation, le peptide se retrouve sous plusieurs formes, dont les formes oligomériques qui présentent la plus grande toxicité envers les neurones. Bien qu'il existe une grande diversité de structures chimiques utilisées comme sondes des plaques séniles, le dé

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25

Kassis, Paméla. "Synthèse de pyridines et pyrazines disubstituées par des noyaux aromatiques et indoliques à visée cytotoxique : synthèse et réactivité du trifluoroborate indolique de potassium." Thesis, Orléans, 2010. http://www.theses.fr/2010ORLE2007.

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Le cancer constitue l’une des principales causes de mortalité, plus particulièrement dans l’ensemble des pays développés, et représente, de ce fait aujourd’hui un problème de santé publique majeur.Depuis quelques années, les alcaloïdes marins représentent une source d’inspiration importante pour les chimistes en vue d’obtenir de nouveaux médicaments anticancéreux.Dans cette optique, des recherches effectuées au sein de notre laboratoire ont fait état de la synthèse d’analogues de ces alcaloïdes possédant une structure tris aromatique.Nous avons développé une approche synthétique originale de c

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26

Perlick, Christian. "2,3-Divinyl- und 2-Aryl-3-vinylindole als Bausteine zu Carbazolen und Versuche zur photochemischen und ultraschall-induzierten 1,6-Elektrocyclisierung." [S.l. : s.n.], 2003. http://deposit.ddb.de/cgi-bin/dokserv?idn=969561350.

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27

Wieczysty, Martin David. "C-H functionalisation of 2-aryl cyclic 1,3-dicarbonyl compounds ; Enantioselective Rh(I)-catalysed cyclisation of arylboron compounds onto ketones." Thesis, University of Edinburgh, 2015. http://hdl.handle.net/1842/18741.

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1. C–H Functionalisation of 2 Aryl Cyclic 1,3-Dicarbonyl Compounds Two enolate-directed C–H functionalisation protocols have been developed using 2-aryl cyclic 1,3-dicarbonyl compounds as substrates. Reactions with activated alkenes, under ruthenium or palladium catalysis produced benzopyrans in most cases, in moderate to good yield. Alternatively, an oxidative annulation of 2-aryl cyclic 1.3-dicarbonyls with 1,3-enynes was facilitated under rhodium catalysis, forming functionalised spiroindene structures in most cases, in generally good yields and high regioselectivity. During the investigati

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28

Courvoisier, Laurent. "Polymorphisme et cristallisation préférentielle : applications aux dérivés(+-)5-méthyl-5-aryl-imidazolidine 2,4-dione et au (+-)(2-(diphénylméthyl)sulfinyl)acétamide." Rouen, 2003. http://www.theses.fr/2003ROUES020.

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Le dédoublement par cristallisation préférentielle de dérivés 5-méthyl-5-aryl-imidazolidine-2,4-dione a été réalisé selon deux procédés AS3PC (Auto-Seeded Programmed Polythermic Preferential crystallization) à une échelle de 2L et 10 L. Le suivi de l'évolution de la population de particules pendant la cristallisation permet de conclure que l'effet d'entraînement n'est pas le fait d'un mécanisme unique. L'effet du polymorphisme a été étudié sur les deux procédés. Cinq nouvelles formes polymorphiques et quatre solvates du(+ -)(2-(diphénylméthyl)sulfinyl)-N-acétamide ont été préparés et caractéri

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29

Charoensutthivarakul, Sitthivut. "From medicinal chemistry optimisation of antimalarial 2-aryl quinolones to synthesis and application of endoperoxide activity-based protein profiling probes." Thesis, University of Liverpool, 2014. http://livrepository.liverpool.ac.uk/2006416/.

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Malaria is one of the most prevalent and deadliest parasitic diseases affecting various systems of the body and leading to death. Resistance against antimalarial treatment is a major threat in controlling and eliminating malaria. New drugs are urgently needed especially when artemisinin resistance has emerged. The mitochondrial electron transport chain of Plasmodium falciparum is an attractive target for chemotherapy. Two enzymes in the pathway - Pfbc1 and PfNDH2 - are druggable target enzymes. The dual inhibition of both enzymes can be seen in 2-aryl quinolone pharmacophore giving added thera

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30

Perry, Philip J. "Synthesis and biological evaluation of novel cytotoxic heterocylic compounds : furo[2,3-b]naphthoquinones and 2-aryl-4H-3,1-benzoxazin-4-ones." Thesis, De Montfort University, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.391202.

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31

Marzouk, Hatem. "Electrochimie de complexes du nickel actifs en catalyse homogene : application a l'electrosynthese d'acides aryl-2 propioniques, d'alpha -dicetones et de cetones." Paris 6, 1987. http://www.theses.fr/1987PA066513.

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32

Li, Chien-Ming. "In Vitro and in Vivo Pharmacology of 4-Substituted Methoxybenzoyl-Aryl-Thiazoles (SMART) and 2-Arylthiazolidine-4-Carboxylic Acid Amides (ATCAA)." The Ohio State University, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=osu1281966183.

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33

Marzouk, Hatem. "Electrochimie de complexes du nickel actifs en catalyse homogène applications à l'électrosynthèse d'acides aryl-2 propioniques, d'alpha dicétones et de cétones /." Grenoble 2 : ANRT, 1987. http://catalogue.bnf.fr/ark:/12148/cb376077856.

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34

Belot, Vincent. "Accès à une bibliothèque ciblée de n-aryl-thiazoline-2-thiones pour l'établissement d'une nouvelle échelle de taille de substituants usuels." Thesis, Aix-Marseille, 2017. http://www.theses.fr/2017AIXM0408/document.

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Une échelle de taille contenant 20 substituants usuels en chimie a été construite à partir des barrières de rotations de N-aryl-thiazoline-2-thiones. L’énergie d’activation ΔG≠rot qui est mesurée reflète l’encombrement stérique du substituant en ortho du cycle benzénique. Les perturbations électroniques, et les facteurs externes tels que la température ou le solvant sont négligeables. La grande sensibilité du modèle proposé conduit au classement suivant Me > Cl et CN > OMe > OH. Ces classements divergents décrits dans la littérature seront discutés. Une limitation du modèle proposé co

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35

Belot, Vincent. "Accès à une bibliothèque ciblée de n-aryl-thiazoline-2-thiones pour l'établissement d'une nouvelle échelle de taille de substituants usuels." Electronic Thesis or Diss., Aix-Marseille, 2017. http://www.theses.fr/2017AIXM0408.

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Une échelle de taille contenant 20 substituants usuels en chimie a été construite à partir des barrières de rotations de N-aryl-thiazoline-2-thiones. L’énergie d’activation ΔG≠rot qui est mesurée reflète l’encombrement stérique du substituant en ortho du cycle benzénique. Les perturbations électroniques, et les facteurs externes tels que la température ou le solvant sont négligeables. La grande sensibilité du modèle proposé conduit au classement suivant Me > Cl et CN > OMe > OH. Ces classements divergents décrits dans la littérature seront discutés. Une limitation du modèle proposé co

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36

Whipp, Christopher J. "Part 1: The Direct Arylation of Azine N-Oxides with Aryl Triflates Part 2: The Site-Selective Direct Arylation of Substituted Indoles." Thesis, University of Ottawa (Canada), 2010. http://hdl.handle.net/10393/28792.

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Part 1: The Direct Arylation of Azine N -Oxides with Aryl Triflates. Two sets of conditions for the palladium-catalyzed direct arylation of azine N-oxides with aryl triflates have been developed. Using palladium(II) acetate, a trialkylphosphine ligand, a carbonate base and pivalic acid, both mono- and diarylated azine N-oxides could be synthesized in good to excellent yields.* The reaction regioselectivity was examined for 3-substituted pyridine N-oxides, with arylation at C2 being favoured. The methodology was applied to the efficient formal synthesis of a biologically active diaryl pyridin

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37

Cancino, Cardenas Miguel Angel. "Amélioration de l'activité et de l'énantiosélectivité de la lipase Lip2 de Yarrowia lipolityca vis-à-vis des acides 2-Bromo-Aryl-Acétique." Toulouse, INSA, 2008. http://eprint.insa-toulouse.fr/archive/00000284/.

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La lipase Lip2 de la levure Yarrowia lipolytica a été démontrée être un catalyseur efficace pour le dédoublement de mélanges racémiques d’acides 2-bromo aryl acétique, une famille importante d’intermédiaires dans l’industrie pharmaceutique. La valeur de l’énantiosélectivité de cette enzyme vis-à-vis du mélange racémique d’acide 2-bromo-p-tolyl acétique est de 28, valeur identique à la l’enzyme la plus performante, la lipase de Burkholderia cepacia. Mais surtout, c’est la seule enzyme capable de dédoubler le mélange racémique d’acide 2-bromo-o-tolyl acétique (précurseur d’un analgésique) (E = 2

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38

Spadafora, Marie. "Synthèse stéréosélective de nucléosides ratiométriques fluorescents de type 2-aryl-3-hydroxychromone : incorporation dans des séquences d'oligonucléotides et étude des propriétés biophysiques." Nice, 2008. http://www.theses.fr/2008NICE4090.

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La spectroscopie de fluorescence est un outil extrêmement sensible pour étudier les interactions acides nucléiques/ligands et leur dynamique. Cependant, les sondes fluorescentes dérivées d’analogues de nucléosides actuellement disponibles présentent des inconvénients qui limitent leur utilisation. C’est pourquoi, la recherche d’analogues nucléosidiques présentant des propriétés de fluorescence optimisées fait l’objet d’efforts soutenus. D’autres part, les 3-hydroxychromones (3-HC) sont des sondes de fluorescence sensibles qui possèdent des propriétés remarquables, exploitées entre autres, pour

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Turek, Pavel. "Příprava 6-aryl- a 6-heteroarylpurinů [2+2+2] -cyklotrimerizacemi." Doctoral thesis, 2009. http://www.nusl.cz/ntk/nusl-280371.

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SOUHRN 1) Byly zavedeny tři rostlinné expresní systém umožňující produkci biologicky aktivních proteinů. První využívá dočasné exprese z vektoru dopraveného do buňky Agrobacteriem po infiltraci listů tabáku bakteriální suspenzí. Pomocí tohoto systému jsme schopni vyprodukovat množství rekombinantního proteinu dosahujícího 5% CRP během 3 dnů. Druhý expresní systém využívá suspenzní kultury stabilně transformovaného mechu Physcomitrella patens. Za kontrolovaných podmínek pěstování v bioreaktoru je výtěžek rekombinantního proteinu srovnatelný s výtěžkem z agroinfiltrace. Expresní systém využívají

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40

Lesenyeho, Lehlogonolo Godfrey. "Palladium-catalyzed heteroannulation of 2-ARYL- 3-IODO-4-(Phenylamino)quinolines and 4-(N,N-allylphenylamino)-2-ARYL-3-iodoquinolines." Diss., 2010. http://hdl.handle.net/10500/3970.

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The previously described 2-aryl-4-chloro-3-iodoquinolines were prepared following literature procedure and in turn converted to the corresponding hitherto unknown 2-aryl-3-iodo-4-(phenylamino)quinoline derivatives using aniline in refluxing ethanol. These 2-aryl-3-iodo-4-(phenylamino)quinolines were reacted with allybromide in ethanol at room temperature to afford 4-(N,N-allylphenylamino)-2-aryl-3-iodoquinoline derivatives. The 2-aryl-3-iodo-4-(phenylamino)quinoline and 4-(N,N-allylphenylamino)-2-aryl-3-iodoquinoline derivatives were subjected to metal-catalysed carbon-carbon bond formations.

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41

Hway-Ru, Yang, and 楊惠如. "Studies in Chemical Activity of Aryl-2-halogenocyclopropane." Thesis, 1994. http://ndltd.ncl.edu.tw/handle/38589682256135211254.

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碩士<br>靜宜大學<br>應用化學系<br>82<br>1-芳香基-2,2-二氯環丙烷化合物具高度環張力及電子密度，在進行硝化反應後，可得異▌▌之開環產物﹔對含其他取代基之苯基環丙烷，如甲基、氯甲基、苯環或是以基取代苯基，進行硝化反應，來探討溫度及NO2+ 與反應物之比例對產物分佈之影響，除了1-甲基-1-苯基-2,2-二鹵環丙烷形成開環主產物 5-甲基-5-(4'-硝基苯)-3-鹵異▌▌▌外，其他六個環丙烷化合物的產物皆以苯環上硝基取代為主之原因。另外，利用電腦輔助分子模擬之理論計算—半經驗法，來探討一系列1-芳香基-2-鹵環丙烷的環丙烷上三個碳原子之13C NMR SCS值、Hammett值與三種方法(MNDO,AM1, PM3)之電荷密度的關係，並得到三種方法之電荷密度值皆可與1-芳香基環丙烷之13C NMR SCS值、Hammett值相呼應，但順-1-芳香基-2-溴環丙烷之Cβ，1-芳香基-2,2-二氯環丙烷之Cβ、Cγ及1-芳香基-2,2-二溴環丙

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42

XU, WEN-JIE, and 徐文杰. "Cycloaddition of trichloronitrosomethane with 2-aryl-1,3-butadienes." Thesis, 1987. http://ndltd.ncl.edu.tw/handle/77706068044871151993.

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43

Lai, Kuan-Yu, and 賴冠妤. "(1) Palladium-catalyzed synthesis of indenobenzofuran from 2-(2-bromobenzoyl)benzofurans(2) Pd-catalyzed the chemoselective synthesis of 4-aryl-4H-chromenes from 2H-chromenes and aryl iodide." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/13883605516297789187.

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碩士<br>高雄醫學大學<br>醫藥暨應用化學研究所<br>100<br>Chapter I The key intermediate 2-(2-bromobenzoyl)benzofurans, prepared from salicylaldehydes and 2-bromo-1-(2-bromophenyl)ethanone, were subjected to an intramolecular cyclization catalyzed by Pd(II) to undergo the Heck reaction to yield 6H-indeno[2,1-b]benzofuran-6-ones in moderate to good yields. Meanwhile their congener indenoneaphthofuran also was prepared. Chapter II A new and chemoslective preparation of 4-aryl-4H-chromenes from 3-cyano-2H-chromenes and aryl iodide catalyzed by Pd was described. The key intermidiates, 3-cyano-2H-chromenes prepared fro

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44

Lin, Yu-Hsiang, and 林育祥. "Click Reaction of Alkynyl Stannane with Aryl AzideAnd Synthesis of N-Polyaromatic Compounds via [2+2+2]-Cycloaddition Reaction." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/14064278809527023677.

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碩士<br>淡江大學<br>化學學系碩士班<br>100<br>Part I: [1,2,3]-Triazoles often exhibit biological activity which may be used as antibacterial or anti-HIV drug.Aryl halides were converted to a variety of aryl azide and which were further reacted with alkynyl stannane by “Click” reaction to produce triazole compounds. Part II: Nitrogen-containing polycyclic aromatic compounds generally exhibit biologically activities such as anti-cancer or anti-bacterial activities.The coupling reaction of 2-ethynylbenzaldehyde with various haloaromatic compounds or the coupling reaction of 2-bromobenzaldehyde with a

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45

Chen, Li-Chun, and 陳麗純. "The Study of 1-Aryl-2-bromo- 3,3-difluorocyclopropenes." Thesis, 2000. http://ndltd.ncl.edu.tw/handle/96189428568728995273.

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碩士<br>靜宜大學<br>應用化學系<br>89<br>Abstract The difluorostyrenes can be prepared in good yield by heating a diglyme solution containing cooresponding aldehyde, triphenylphosphine, and sodium chlorodifluoroacetate. A series of novel 1-aryl-2-bromo- 3,3-difluorocyclopropenes were prepared from the reaction of various difluorostyrenes and bromoform in the presence of an organic base for the study on the substituent-induced chemical shifts (SCS) of C(α,β,γ) using the 13C NMR spectral analyses. The correlation between SCS and Hammett constants (σ) shows that the substituent effect via resona

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46

Matoušová, Eliška. "Syntéza derivátů 2-aryl-4-methyl-cyklopent-2-en-1-onu s potenciální antifungální aktivitou." Master's thesis, 2007. http://www.nusl.cz/ntk/nusl-280110.

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THE SYNTHESIS OF THE DERIVATIVES OF 2-ARYL-4-METHYLCYKLOPENT-2-EN-1-ONE WITH POTENTIAL ANTIFUNGAL ACTIVITY Eliška Matoušová ABSTRACT Several series of compounds with potential antifungal activity related to a national product incrustoporine have been synthesized in last years. The aim of this thesis was to prepare the set of carbanalogues of incrustoporine (2-arylderivatives of 4-methylcyklopent-2-en-1-one) to find whether the substitution of oxygen atom in lactone group by methylen would have any influence on the activity. We found that the antifungal effect of these compounds was very low. I

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47

Wu, Chia fen, and 吳佳芬. "(1) Synthesis of 2-tetralones by titanium tetrachloride-Promoted cyclization of 4-aryl-2-hydroxybutanal dimethyl acetals.(2) Synthesis of benzocoumarins from 2-tetralones." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/77040416790529510687.

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碩士<br>國立中正大學<br>化學所<br>98<br>(1) 2-tetralone is useful in synthetic chemistry, it could be used in many kinds of applications, such as precursors of several natural products and their derivatives, starting materials for synthetic compounds with biological activities and other useful properties. So far, it is not safe and efficient Methodologies from the monocyclic aromatic precursor such as the potential carcinogenicity hazards associated with diazo compound and low boling point ethylene as reagent to preapare 2-tetralone. A general and efficient methodology to prepare 2-tetralone deriva

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48

Siuts, Antje. "Synthese von neuen 3-Aryl-2-oxazolidinonen als antibakterielle Wirkstoffe /." 1994. http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&doc_number=006651747&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA.

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49

Chen, I.-Hsiang, and 陳宜香. "Design and Synthesis of 1-(6-(2-(2-(2-Aryl)ethynyl)phenyl)hex-5-ynyl)piperidin-2-ones Derivatives to induce Apoptotic Progress with Antitumor Activity." Thesis, 2007. http://ndltd.ncl.edu.tw/handle/95636210811543295377.

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碩士<br>高雄醫學大學<br>醫藥暨應用化學研究所碩士班<br>95<br>1-(6-(2-(2-(2-Aryl)ethynyl)phenyl)hex-5-ynyl)piperidin-2-ones 46-57 were designed and synthesized to evaluate for cell cycle of human leukemia K-562 tumor cell line, and the cytotoxic responses against sixty human tumor cell line. Some of compounds presented biological activities in this evaluation course, in which compounds 47 and 48 exhibited S phase arrested activities and compounds 55 and 56 induced apoptotic progress。

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50

Paul, Somak. "Synthesis Of 2-Deoxy-1-Thioglycosides And Establishing Their Efficient Glycosyl Donor Properties To Prepare Aryl 2-Deoxy Glycosides And 2-Deoxy Oligosaccharides." Thesis, 2008. https://etd.iisc.ac.in/handle/2005/737.

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Carbohydrates are a family of polyfunctional natural products and can be chemically modified in numerous ways. The primary significance of carbohydrates rests in their importance in biological functions. A particular class of sugars, namely, 2-deoxy or C-2 modified sugars has received a special attention, due to their importance in biological functions. These sugars are defined as carbohydrates carrying a hetero-atom, other than the hydroxyl group, and their derivatives. There is an ever-leading requirement to synthesize various carbohydrates-containing natural and un-natural products, such as

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