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Journal articles on the topic '2-aryl-4-chloro-6'

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Published: 4 June 2021

Last updated: 1 February 2022

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1

Bhat, Balkrishen, and A. P. Bhaduri. "Grignard Reaction of 2-Substituted-3-Cyanoquinolines." Zeitschrift für Naturforschung B 40, no. 7 (1985): 990–95. http://dx.doi.org/10.1515/znb-1985-0724.

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Abstract Grignard reactions of 2-morpholino and 2-methylthio-3-cyanoquinoline, 2-chloro-3-cyanoquinoline, 2-chloro-3-cyano-6-methoxyquinoline and 2-chloro-3-cyano-7-methylquinoline with alkyl or aryl magnesium halides have been studied. It was found that 2-morpholino and 2-methylthio- 3-cyanoquinolines gave 1,4-addition products followed by rapid aromatisation. 2-Chloro-3- cyanoquinoline with alkyl magnesium halides furnished 1,4-addition products but with aryl magnesium halides 1,4- and 1,2-addition products were obtained. The cyano group of 4-aryl-2-chloro- 3-cyano-1,4-dihydroquinolines was

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2

Ofitserova, E. S., L. N. Alekseeva, A. A. Shklyarenko, and I. P. Yakovlev. "Biological Activity of New 1-Benzoyl-Subctituted 6-(Methylthio)-4-Chloro-1h-Pyrazolo[3,4-D]Pyrimidines." Medicina 8, no. 3 (2020): 76–84. http://dx.doi.org/10.29234/2308-9113-2020-8-3-76-84.

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The article presents results of the study of the biological activity of newly synthesized 1-benzoyl-substituted-6- (methylthio) -4-chloro-1H-pyrazolo [3,4-d] pyrimidines. The acute toxicity of 2-aryl-6- (methylthio) -4-chloro-2H-pyrazolo [3,4-d] pyrimidines was determined experimentally on non-linear white male mice with a total weight of 16-20 g. A generation model was used to experimentally evaluate the analgesic activity acetic "writhing" in mice. It was experimentally confirmed that the synthesized new 2-aryl-6- (methylthio) -4-chloro-2H-pyrazolo [3,4-d] pyrimidines are non-toxic and have

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3

Schmitt, Martine, Jean-Jacques Bourguignon, Gordon B. Barlin, and Les P. Davies. "Imidazo[1,2-b]pyridazines. XXIII Some 5-Deaza Analogues. Syntheses of Some 2-Aryl-6-(chloro, methoxy or unsubstituted)-3- (variously substituted)imidazo[1,2-a]pyridines and Their Affinity for Central and Mitochondrial Benzodiazepine Receptor." Australian Journal of Chemistry 50, no. 7 (1997): 719. http://dx.doi.org/10.1071/c97004.

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The syntheses of ethyl {2′-aryl-6′-(chloro, methoxy and unsubstituted)imidazo[1,2-a]pyridin-3′-yl}-2- (acylamino, acetoxy and hydroxy)acetates, 3-benzamidomethyl-2-benzoyl-6-(chloro and methoxy)imidazo-[1,2-a]pyridines, 3-amino-6-chloro-2-phenylimidazo[1,2-a]pyridine and ethyl 2-(2′-phenylimidazo[1,2-a]pyridin-3′-yl)acetate are reported. The ability of these compounds to displace [3H]diazepam from central and mitochondrial (peripheral-type) benzodiazepine receptors has been examined. Ethyl 2-benzamido-2-{6′-chloro-2′-(4′′-chlorophenyl)imidazo[1,2-a]pyridin-3′-yl} acetate (21) was selective for

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4

Atbakar, Muge, Onur Topbastekin, and Nuket Ocal. "Reductive Heck reactions of N-arylamino-substituted tricyclic imides." Journal of the Serbian Chemical Society 81, no. 10 (2016): 1121–25. http://dx.doi.org/10.2298/jsc160218062a.

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The C-C coupling of N-(3-chloro-4-fluorophenyl)amino-bicyclo[2.2.1] hept-8-ene-2-endo,6-endo-dicarboximide (3) which was prepared as a new starting material and N-(2,4-dinitrophenyl)aminobicyclo[2.2.1]hept-8- -ene-2-endo,6-endo-dicarboximide (6) with aryl- and heteroaryl iodides gave the aryl(hetaryl), N-arylaminotricyclic imides 4a-d and 7a-d under reductive Heck conditions.

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5

Mishra, AD. "A Convenient route for the synthesis of antimicrobial 1, 3, 4- thiadiazole derivatives." BIBECHANA 8 (January 15, 2012): 17–22. http://dx.doi.org/10.3126/bibechana.v8i0.4766.

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Thiosemicarbazide of 6-chloro-2- aminobenzothiazole on cyclization with different aromatic carboxylic acids in Phosphorus oxychloride provided the corresponding 2-aryl-5-(6’-chloro-1’,3’-benzothiazole-2-yl-amino)-1,3,4-thiadiazoles 4a-j. The compounds are characterized by elemental analysis, IR and 1H NMR spectral data. All the compounds are evaluated in vitro for their antimicrobial activities against several fungal and bacterial strains and showed significant activities.Keywords: Aminobenzothiazole; 1, 3, 4- thiadiazole; antimicrobial; cyclizationDOI: http://dx.doi.org/10.3126/bibechana.v8i0

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6

Jalander, Lars F., and Jan-Erik Lönnqvist. "Synthesis of Alkyl- and Phenyl-2-thiouracils and 1,3-Thiazin-4-ones by Nucleophilic Substitution of Unsymmetrical Thioureas with 3-Chloropropenoates." Collection of Czechoslovak Chemical Communications 64, no. 8 (1999): 1307–15. http://dx.doi.org/10.1135/cccc19991307.

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Unsymmetrically substituted thioureas and ethyl (E)- and (Z)-3-aryl-3-chloro-2-cyano- propenoates (1a) and (1b) gave after nucleophilic vinylic substitution and cyclisation two isomers of 1,3-disubstituted 6-aryl-5-cyano-2-thiouracil derivatives, 3a-3i and 4a-4i. Substituted 1,3-thiazin-4-ones 5a-5d were formed in moderate to good yields when monosubstituted thioureas were allowed to react under similar conditions.

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7

Nauš, Petr, Martin Kuchař, and Michal Hocek. "Cytostatic and Antiviral 6-Arylpurine Ribonucleosides IX. Synthesis and Evaluation of 6-Substituted 3-Deazapurine Ribonucleosides." Collection of Czechoslovak Chemical Communications 73, no. 5 (2008): 665–78. http://dx.doi.org/10.1135/cccc20080665.

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A series of 3-deazapurine ribonucleosides 5a-5l bearing diverse C-substituents (alkyl, aryl and heteroaryl) in the position 6 were prepared by Pd-catalyzed cross-coupling reactions of either free 6-chloro-3-deazapurine ribonucleoside 4 or its acetyl protected congener 3 followed by deprotection. An improved synthesis of the starting 4-chloro-1-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)-1H-imidazo[4,5-c]pyridine (3) was developed by the application of Vorbrüggen glycosylation of silylated nucleobase with 1,2,3,5-tetra-O-acetyl-β-D-ribofuranose (2). None of compounds 5a-5l showed any considerable cy

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8

Baldaniya, B. B., and P. K. Patel. "Synthesis, Antibacterial and Antifungal Activities ofsDerivatives." E-Journal of Chemistry 6, no. 3 (2009): 673–80. http://dx.doi.org/10.1155/2009/196309.

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SeveralNʹ-{4-[(3-chloro-4-fluorophenyl) amino]-6-[(-aryl) amino] -1, 3, 5-triazin-2-yl} isonicotinohydrazides (6a-r) andN2-(Aryl)-N4,N6-dipyrimidin-2-yl-1,3,5-triazine-2,4,6-triamines (4a-o) were prepared. All newly synthesized compounds have been tested for their antibacterial activity against gram (+)ve and gram (-)ve bacteria and also on different strains of fungi. Introduction of -OH, -OCH3, -NO2, -Cl and -Br groups to the heterocyclic frame work enhanced antibacterial and antifungal activities.

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9

Kalme, Z. A., B. Roloff, Yu E. Pelcher, Yu Yu Popelis, F. Khagen, and G. Ya Dubur. "Reactions of nucleophilic substitution of 4-aryl-5-carbomethoxy-6-methyl-2-chloro-3-cyanopyridines." Chemistry of Heterocyclic Compounds 28, no. 12 (1992): 1411–15. http://dx.doi.org/10.1007/bf00531295.

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10

Schmitt, Martine, Jean-Jacques Bourguignon, Gordon B. Barlin, and Les P. Davies. "Imidazo[1,2-b]pyridazines. XXIV Syntheses of Some 3-(Variously Substituted) Imidazo[1,2-b] pyridazines, 6-Substituted 2-Benzoyl- imidazo[1,2-b]pyridazines and Pyrimido[1,2-b]pyridazin- 5-ium-3-olates and their Interaction with Central and Mitochondrial Benzodiazepine Receptors." Australian Journal of Chemistry 50, no. 8 (1997): 779. http://dx.doi.org/10.1071/c97030.

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The syntheses of some ethyl 2-{2′-aryl-6′-(chloro, iodo and methoxy)imidazo[1,2-b]pyridazin-3′-yl}-2-(acetoxy, acylamino, hydroxy and methoxy)acetates, 6-methyl-2-(p-tolyl)- and 6-chloro-2-(4′-chlorophenyl)-3-trimethylammoniomethylimidazo[1,2-b]pyridazine iodides (and reactions thereof), 2-benzoyl 6-substituted imidazo[1,2-b]pyridazines and 7-(methoxy, chloro and phenylthio)-2-phenylpyrimido-[1,2-b]pyridazin-5-ium-3-olates are reported. The ability of these compounds to displace [3H]diazepam from rat forebrain membrane [central benzodiazepine receptor (BZR)] and rat kidney membrane [mitochondr

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11

Cheng, Pi, Quan Zhang, Yun-Bao Ma, et al. "Synthesis and in vitro anti-hepatitis B virus activities of 4-aryl-6-chloro-quinolin-2-one and 5-aryl-7-chloro-1,4-benzodiazepine derivatives." Bioorganic & Medicinal Chemistry Letters 18, no. 13 (2008): 3787–89. http://dx.doi.org/10.1016/j.bmcl.2008.05.065.

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12

KALME, Z. A., B. ROLOFF, YU E. PELCHER, YU YU POPELIS, F. HAGEN, and G. YA DUBUR. "ChemInform Abstract: Nucleophilic Substitution Reactions of 4-Aryl-5-carbomethoxy-6-methyl- 2-chloro-3-cyanopyridines." ChemInform 24, no. 38 (2010): no. http://dx.doi.org/10.1002/chin.199338215.

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13

Mphahlele, Malose, Hugues Paumo, Lydia Rhyman, and Ponnadurai Ramasami. "Synthesis and Photophysical Properties of Polycarbo-Substituted Quinazolines Derived from the 2-Aryl-4-chloro-6-iodoquinazolines." Molecules 20, no. 8 (2015): 14656–83. http://dx.doi.org/10.3390/molecules200814656.

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14

Soni, Hetal I., and Navin B. Patel. "PYRIMIDINE INCORPORATED SCHIFF BASE OF ISONIAZID WITH THEIR SYNTHESIS, CHARACTERIZATION AND IN VITRO BIOLOGICAL EVALUATION." Asian Journal of Pharmaceutical and Clinical Research 10, no. 10 (2017): 209. http://dx.doi.org/10.22159/ajpcr.2017.v10i10.19302.

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Objective: Versatile biological activities of nitrogen containing heterocycles in medicinal chemistry, mainly pyrimidine and pyridine ring based heterocyclic moieties are very important. Pharmaceutical important of pyrimidine and isoniazid moiety prompted us to synthesize isoniazid clubbed pyrimidine derivatives and evaluated for antimicrobial and antituberculosis activity.Method: 2-(2-(3-bromo benzylidene)-1-isonicotinoyl hydrazinyl)-N-(4-(substituted phenyl)-6-(substituted aryl) pyrimidin-2-yl) acetamide 2(A-J) have been synthesized by condensation reaction of 2-chloro-N-[4-(substituted phen

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15

Li, Zuguang, Kexian Chen, Haiying Xie, Yan Wang, and Fengchao Dong. "Cluster Analysis and QSAR Study of Some Anti-hepatitis B Virus Agents Comprising 4-Aryl-6-chloro-quinolin-2-ones and 5-Aryl-7-chloro-1,4-benzodiazepines." Chinese Journal of Chemistry 27, no. 12 (2009): 2352–58. http://dx.doi.org/10.1002/cjoc.201090007.

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16

Rasool, Shahid, Aziz-ur-Rehman, Muhammad Athar Abbasi, et al. "Synthesis, Structural Elucidation, and Antibacterial Evaluation of Some New Molecules Derived from Coumarin, 1,3,4-Oxadiazole, and Acetamide." Organic Chemistry International 2016 (September 7, 2016): 1–10. http://dx.doi.org/10.1155/2016/8696817.

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Because of the reported biological activities of coumarin, 1,3,4-oxadiazole, and acetamides, some new compounds incorporating these moieties were synthesized and evaluated for their biological potential against Gram-positive and Gram-negative bacteria. In the present work, 4-chlororesorcinol (1) and ethyl acetoacetate (2) were mixed in a strong acidic medium to synthesize 6-chloro-7-hydroxy-4-methyl-2-oxo-2H-chromene (3) which was subjected to the intermolecular cyclization after consecutive three steps to synthesize 5-[(6-chloro-4-methyl-2-oxo-2H-chromen-7-yl)oxy]methyl-1,3,4-oxadiazol-2-thio

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17

Csuk, René, Sven Sommerwerk, Jana Wiese, et al. "Isolation, Structure, Synthesis and Cytotoxicity of an Unprecedented Flupirtine Dimer." Zeitschrift für Naturforschung B 67, no. 12 (2012): 1297–304. http://dx.doi.org/10.5560/znb.2012-0258.

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A previously unknown dimer of the well-established analgesic flupirtine has been found, and its structure was revealed by ESI-MS, NMR spectroscopy and an independent synthesis. Thus, starting from 2-amino-6-chloro-3-nitro-pyridine the target compound was obtained in a four-step synthesis. Key-step of this synthesis is a nickel-mediated aryl-aryl coupling. The dimer 4 did not show any cytotoxicity, and its IC50 values were > 30 μm for all six human cancer cell lines and mouse fibroblasts used in this study

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18

Ofitserova, E. S., L. N. Alekseyeva, A. A. Shklyarenko, and I. P. Yakovlev. "BIOLOGICAL ACTIVITY OF NEW 2-ARYL-6-(METHYLTHIO)-4-CHLORO-2H-PYRAZOLO [3,4-D] PYRIMIDINES." Вестник Смоленской государственной медицинской академии 19, no. 4 (2020): 46–49. http://dx.doi.org/10.37903/vsgma.2020.4.7.

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19

Girreser, Ulrich, Dieter Heber, Mojgan Rostaie-Gerylow, and Martin Schütt. "Reactions of 3-Chloropropeniminium Salts with Aminopyridines. Synthesis of N-Pyridylpyridinium and Pyrido[1,2-a]pyrimidinium Salts." Zeitschrift für Naturforschung B 59, no. 4 (2004): 424–30. http://dx.doi.org/10.1515/znb-2004-0410.

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AbstractN-(Pyridyl)pyridinium salts 7 and 8 as well as 4-phenylpyrido[1,2-a]pyrimidinium salts 4 and 12 have been prepared by reactions of 3-aryl-3-chloropropeniminium salts 5 with aminopyridines (6) using glacial acetic acid as solvent. 2-Phenylpyrido[1,2-a]pyrimidinium salts 2 are formed when ethanol is used as the solvent. The condensation of 2-aminopyridine (6a) with 3-chloro-2,3- dehydromorpholino-2-carbiminium salt 13 is described. The HSAB principle of Pearson is discussed to explain the different regioselective ring closure reactions.

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20

Astaneh, H. R. Haghjoo, and E. O. Moradi Rufchahi. "Use of Nanocrystalline ZnO as an Efficient and Reusable Catalyst for a One-Pot, Three-Component Synthesis of 6-Chloro- and 5,7-Dichloro-4-Hydroxy-3-[Aryl (Piperidin-1-yl)Methyl]Quinolin-2(1H)-Ones in Water." Journal of Chemical Research 42, no. 2 (2018): 116–20. http://dx.doi.org/10.3184/174751918x15192990175864.

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A one-pot, green, efficient and facile procedure was applied for the preparation of a series of 4-hydroxy-3-[aryl(piperidin-1-yl)methyl] quinolin-2(1 H)-ones via the reaction of 6-chloro-4- hydroxyquinoline-2(1 H)-one 1 and/or 5,7-dichloro-4-hydroxyquinoline-2(1 H)-one 2, piperidine and aromatic aldehydes in water in the presence of nanocrystalline ZnO under reflux conditions. The desired products were obtained in satisfactory yields. The nanocrystalline ZnO can be separated and reused at least up to three times with almost the same catalytic activity.

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21

Ruiz, Enrique, Hortensia Rodríguez, Julieta Coro, et al. "Efficient sonochemical synthesis of alkyl 4-aryl-6-chloro-5-formyl-2-methyl-1,4-dihydropyridine-3-carboxylate derivatives." Ultrasonics Sonochemistry 19, no. 2 (2012): 221–26. http://dx.doi.org/10.1016/j.ultsonch.2011.07.003.

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22

Hegab, Mohamed I., Nasser A. Hassan, and Farouk M. E. Abdel-Megeid. "Three-component Reaction of Cycloheptanone, 6-Amino-1,3-Dimethyluracil and Aromatic Aldehydes; X-Ray Structure, and Anti-inflammatory Evaluation of the Products." Zeitschrift für Naturforschung B 63, no. 9 (2008): 1117–26. http://dx.doi.org/10.1515/znb-2008-0917.

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1,3-Dimethyl-5-aryl-1,6,7,8,9,10-hexahydrocyclohepta[5,6]pyrido[2,3-d]pyrimidine-2,4-diones 4a, b (the linear regioisomers) and the Schiff bases, 6-N-benzylidenamino-1,3-dimethyluracil derivatives 5a, b, were isolated from a three-component reaction of cycloheptanone, 6-amino-1,3- dimethyluracil, and 4-chloro- or 4-bromobenzaldehyde. Surprisingly, 1,3-dimethyl-10-aryl-1,5,6,7, 8,9-hexahydrocyclohepta[4,5]pyrido-[2,3-d]pyrimidine-2,4-diones 6f, g (the angular regioisomers which are described for the first time in the literature under the given reaction conditions) and the Schiff bases, 6-N-benz

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23

Sharif, Muhammad, Khurram Shoaib, Shahzad Ahmed, et al. "Synthesis of functionalised fluorinated pyridine derivatives by site-selective Suzuki-Miyaura cross-coupling reactions of halogenated pyridines." Zeitschrift für Naturforschung B 72, no. 4 (2017): 263–79. http://dx.doi.org/10.1515/znb-2016-0213.

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AbstractThe Suzuki-Miyaura reaction of 2,6-dichloro-3-(trifluoromethyl)pyridine with 1 equiv of arylboronic acids resulted in site-selective formation of 2-aryl-6-chloro-3-(trifluoromethyl)pyridine. Due to electronic reasons, the reaction takes place at the sterically more hindered position. The selectivity was rationalised by DFT calculations. The one-pot reaction with two different arylboronic acids afforded 2,6-diaryl-3-(trifluoromethyl)pyridine containing two different aryl substituents. The reactions proceeded smoothly in the absence of phosphine ligands. In addition, Suzuki-Miyaura react

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24

Gali, Amjad. "Synthesis and Biological evaluation of some new 2-thioxoimidazolidin-4-one derivatives (part II)." Al-Mustansiriyah Journal of Science 29, no. 1 (2018): 79. http://dx.doi.org/10.23851/mjs.v29i1.111.

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In the present work adifferent of new heterocyclic compounds were synthesized by reaction of thiosemicarbazide with tow aldehydes (4-bromo benzaldehyde,2-chloro benzaldehyde). the reacting `of compounds(1,2) with ethyl chloroacetate to give 3-[(arylidene)amino]-2-sulfanyl-3,5-dihydro-4H-imidazol-4-one (3,4) which treating with defferent aldehydes togive chalcones . the compound (3) reacted with ethyl aceto acetate to give ethyl 4-aryl-1-[(4-bromo benzylidene)amino]-6-oxo-2-sulfanyl-3a,4,5,6,7,7a-hexahydro-1H-benzimidazole-5-carboxylate,and in series of reaction converted into a variety of deri

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25

Neumüller, Bernhard. "Synthese von Stickstoff- und Chlor-verbrückten Indiumorganylen. Die Kristallstrukturen von [Mes(Cl)InN(SiMe3)2]2 und {i-Pr2In[N(H)t-Bu]2In(Cl)i-Pr} / Synthesis of Nitrogen- and Chloro-Bridged Organoindium Compounds. The Crystal Structures of [Mes(Cl)InN(SiMe3)2]2 and {i-Pr2In[N(H)t-Bu]2In(Cl)i-Pr}." Zeitschrift für Naturforschung B 46, no. 6 (1991): 753–61. http://dx.doi.org/10.1515/znb-1991-0609.

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[(PhCH2)2InN(H)t-Bu]2 (3) and [PhCH2(Cl)InN(SiMe3)2]2 (4) have been prepared by the reaction of (PhCH2)2InCl with LiN(H)t-Bu and of PhCH2InCl2 with NaN(SiMe3)2, respectively. 3 could be isolated in two isomers, while 4 forms only one chloro-bridged isomer in solution and in the solid state. The possibility of a chloro-bridged alkyl(aryl)chloroindium amide is also realized in [Mes(Cl)InN(SiMe3)2]2 (2), as shown by X-ray analysis. The reaction of a 1:1-mixture of i-Pr2InCl/i-PrInCl2 with LiN(H)t-Bu leads to all three possible compounds: [i-Pr(Cl)InN(H)t-Bu]2 (1), {i-Pr2In[N(H)t-Bu]2In(Cl)i-Pr} (

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26

Thakur, Mandeep, Surinder Berar, Urmila Berar, Surinder Arora, Satish C. Gupta, and Ramesh C. Kamboj. "Photo-transformations of 6-chloro-3-propargyloxy-2-aryl-4-oxo-4H-1-benzopyran: 1,4-hydrogen abstraction in propargylethers." Tetrahedron 64, no. 22 (2008): 5168–73. http://dx.doi.org/10.1016/j.tet.2008.03.040.

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27

Das, Rina, and Dinesh Kumar Mehta. "Evaluation and Docking Study of Pyrazine Containing 1, 3, 4-Oxadiazoles Clubbed with Substituted Azetidin-2-one: A New Class of Potential Antimicrobial and Antitubercular." Drug Research 71, no. 01 (2020): 26–35. http://dx.doi.org/10.1055/a-1252-2378.

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Abstract Background Tuberculosis (TB) caused by Mycobacterium tuberculosis is one of the main killers of people all over the world. The major hurdles with existing therapy are the lengthy regimen and appearance of multi drug resistant (MDR) and extensively drug resistant (XDR) strains of M.tuberculosis. Aims The present work was aimed to synthesize and determine antitubercular and antimicrobial potential of some novel 3-chloro-4-aryl-1-[4-(5-pyrazin-2-yl[1,3,4]oxadiazole-2-ylmethoxy)-phenyl]-azetidin-2-one derivatives 7(a-h) from pyrazinoic acid as precursor, which is a well-established antitu

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28

Jun, Taehong, Kibong Kim, Kang Mun Lee, et al. "The inorganic DMSO/POCl3 reaction with BODIPY: wide product formation and implications for biological ROS sensing and neurodegenerative disease research." Journal of Porphyrins and Phthalocyanines 16, no. 11 (2012): 1201–8. http://dx.doi.org/10.1142/s1088424612501180.

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We report a refined and expanded synthetic study of 4,4-difluoro-1,3,5,7-tetramethyl-8-(aryl)-4-bora-3a,4a-diaza-s-indacene under treatment with POCl3/DMSO. The 2-chloro-6-methylsulfide derivative (Kim TI, Park S, Choi Y and Kim Y. Chem. Asian J. 2011; 6: 1358-61.) was one of five co-eluants, including 2,6-disulfido and -dichloro species, and mono-substituted counterparts. The 8-meso tail group modifies product distribution. The different sulfur-containing products undergo different "off-on" responses with NaOCl (10 equiv.). Compounds 4b and 2b exhibit low toxicity and were found to enter juxt

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29

Thompson, Dean G., and Linda M. Macdonald. "Trace-Level Quantitation of Sulfonylurea Herbicides in Natural Water." Journal of AOAC INTERNATIONAL 75, no. 6 (1992): 1084–90. http://dx.doi.org/10.1093/jaoac/75.6.1084.

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Abstract A novel gas chromatographic/electron capture detection (GC/ECD) technique is described for quantitation of trace sulfonylurea herbicide residues in natural water. In this method, the parent sulfonylurea herbicides are isolated from their aryl sulfonamide metabolites by Florisil chromatography, and the acidic aqueous hydrolysis products of the parent compounds are then quantitated. The method has been validated for both metsulfuron methyl (MET; methyl 2-{[(4-methoxy-6-methyl-1,3,5-triazin- 2-yl)aminocarbonyl] aminosulfonyl} benzoate), and chlorsulfuron [CHLOR; 2-chloro-A/-(4-methoxy-6-

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30

Chornous, V. A., A. N. Grozav, and M. V. Vovk. "ChemInform Abstract: Polyfunctional Imidazoles. Part 6. Synthesis of 2-Amino-1-aryl-4-chloro-1H-imidazole-5-carboxylic Acids Derivatives." ChemInform 43, no. 46 (2012): no. http://dx.doi.org/10.1002/chin.201246130.

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31

Samadhiya, Pushkal, Ritu Sharma, Santosh K. Srivastava, and Savitri D. Srivastava. "Synthesis ofN1-3-{(4-Substituted aryl-3-chloro-2-oxo-azetidine)-iminocarbamyl}-propyl-6-nitroindazole Derivatives and Their Biological Significance." Chinese Journal of Chemistry 29, no. 8 (2011): 1745–52. http://dx.doi.org/10.1002/cjoc.201180311.

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32

Kathiriya, P. J., H. D. Purohit, and Dipak M. Purohit. "Synthesis and Antimicrobial Activity of [2"-Aryl(Quinoxaline)-3-yl]-(Methylene Phenyl Amino)-6-[Bis-(2"'-Chloro Ethyl) Amino]-4-Methoxy-1,3,5-Triazine." International Letters of Chemistry, Physics and Astronomy 49 (April 2015): 130–36. http://dx.doi.org/10.18052/www.scipress.com/ilcpa.49.130.

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Sarveswari, S., and V. Vijayakumar. "An Efficient Microwave Assisted Eco-friendly Synthesis of 6-Chloro-3-(3-arylacryloyl)-2-methyl-4-phenylquinolines and their Conversion to 6-Chloro-3-(1-phenyl-5-aryl-4,5-dihydro-1H-pyrazol- 3-yl)-2-methyl-4-phenylquinolines." Journal of the Chinese Chemical Society 59, no. 1 (2012): 66–71. http://dx.doi.org/10.1002/jccs.201100162.

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EL-ABADELAH, M. M., M. R. KAMAL, W. M. TOKAN, and S. O. JARRAR. "ChemInform Abstract: Synthesis and Properties of 1-Aryl-6-chloro-1,4-dihydro-4-oxothieno(2, 3-c)pyridazine-3-carboxylic Acids." ChemInform 28, no. 35 (2010): no. http://dx.doi.org/10.1002/chin.199735172.

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35

Paumo, Hugues K., Malose J. Mphahlele, Lydia Rhyman, and Ponnadurai Ramasami. "Synthesis, photophysical properties and DFT study of novel polycarbo-substituted quinazolines derived from the 2-aryl-6-bromo-4-chloro-8-iodoquinazolines." Tetrahedron 72, no. 1 (2016): 123–33. http://dx.doi.org/10.1016/j.tet.2015.11.014.

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36

Gowda, B. Thimme, K. Jyothi, Helmut Paulus, and Hartmut Fuess. "35Cl NQR and Structural Studies on Substituted Amides, XyC6H5–yNHCOR (X = H or Cl; y = 0, 1 or 2 and R = C(CH3)3, CHClCH3, C6H5 or 2-ClC6H4)." Zeitschrift für Naturforschung A 58, no. 4 (2003): 225–30. http://dx.doi.org/10.1515/zna-2003-0409.

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35Cl NQR frequencies of some N-(substitutedphenyl)-amides represented by the general formula, XyC6H5−yNHCOR (where X = H or Cl; y = 0, 1 or 2 and R = H, CH3, CH2CH3, CH(CH3)2, C(CH3)3, CH2Cl, CHCl2 or CCl3) have been measured and compared with those of other compounds in the family to analyse the effect of substitution in the side chain on the frequencies. Comparison of 35Cl NQR frequencies of all the N-(2-chlorophenyl)- and N-(2,6-dichlorophenyl)-amides reveals that the presence of alkyl groups in the side chain lowers the frequency, while that of aryl or chlorosubstituted alkyl groups enhanc

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Bhat, Gulzar A., Antony Rajendran, and Ramaswamy Murugavel. "Dinuclear Manganese(II), Cobalt(II), and Nickel(II) Aryl Phosphates Incorporating 4′-Chloro-2,2′:6′,2′′-Terpyridine Coligands - Efficient Catalysts for Alcohol Oxidation." European Journal of Inorganic Chemistry 2018, no. 6 (2018): 795–804. http://dx.doi.org/10.1002/ejic.201701064.

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Samadhiya, Pushkal, Ritu Sharma, Santosh K. Srivastava, and Savitri D. Srivastava. "ChemInform Abstract: Synthesis of N1-3-{(4-Substituted aryl-3-chloro-2-oxo-azetidine)-iminocarbamyl}-propyl-6-nitroindazole Derivatives and Their Biological Significance." ChemInform 43, no. 1 (2011): no. http://dx.doi.org/10.1002/chin.201201099.

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Ashok, D., M. Sarasija, D. Shravani, B. Vijayalaxmi, and K. Sudershan. "Microwave assisted selective synthesis of (E)-1-(4-Chloro-7-hydroxy-2-aryl-2H-chromen-6-yl)-3-arylprop-2-en-1-ones and their antimicrobial activity." Russian Journal of General Chemistry 86, no. 4 (2016): 930–33. http://dx.doi.org/10.1134/s1070363216040290.

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Wu, Jie, and Xiaocong Wang. "Facile synthesis of chromeno[4,3-b]quinolin-6-ones from unexpected reactions of aryl isocyanides with 4-chloro-2-oxo-2H-chromene-3-carbaldehyde." Organic & Biomolecular Chemistry 4, no. 7 (2006): 1348. http://dx.doi.org/10.1039/b600540c.

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Chakravart, Arkalgud Satyanarayana Jeevan, та Suresh Hari Prasad. "Regiospecific substitution of the β-vinylic sp2 carbon of cyclohexenones bearing the α-chloro- and β-tosylate-groups: Single crystal XRD/Hirshfeld surface/in-silico studies of three representative compounds". European Journal of Chemistry 11, № 4 (2020): 261–75. http://dx.doi.org/10.5155/eurjchem.11.4.261-275.2020.

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2-Chloro-3-tosyl-5,5-dimethyl-2-cyclohexenone was subjected to a series of regiospecific Suzuki-Miyaura cross-coupling reactions in suspensions of nine different substituted boronic acids, Pd(OAc)2, P(Ph3)3, K3PO4 and 1,4-dioxane solvent, under sealed tube conditions. The regiospecific substitution of the tosyl-group by the aryl group in preference over the chloride- group was observed. A comparison between the bromo- and tosylate group’s reactivities is highlighted. Using the methodology, the products: 2-chloro-3-aryl-5,5-dimethyl-2-cyclohexenones were isolated in greater than 85% yields. Goo

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42

Abu-El-Halawa, Rajab, Mohanad Masad, Yaser Bathich, et al. "Concise Synthesis and Displacement Reactions of Model 3-(Alkylthio)- 6-chloro- and 2,6-Dichlorothieno[2,3-e][1,4,2]dithiazine 1,1-Dioxides." Zeitschrift für Naturforschung B 66, no. 7 (2011): 715–20. http://dx.doi.org/10.1515/znb-2011-0712.

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A series of 3-(alkylthio)-6-chlorothieno[2,3-e][1,4,2]dithiazine 1,1-dioxides (7a - e) were prepared via interaction of deprotonated 2,5-dichlorothiophene-3-sulfonamide with carbon disulfide under reflux, followed by alkylation with alkyl halides. Employment of dimethyl sulfate afforded the isomeric 2-methyl-3-thione derivative 8 together with the expected 3-(methylthio) derivative 7a in a molar ratio of 1 : 4. Treatment of 7a or 10 with ethylamine, aniline or p-chloroaniline produced the corresponding N-ethyl- (or N-phenyl)-6-chlorothieno[2,3-e][1,4,2]dithiazine-3-amine 1,1-dioxides 3a - c. L

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43

GAVINI, E., C. JULIANO, A. MULE, G. PIRISINO, and G. A. PINNA. "ChemInform Abstract: Pyridazine N-Oxides. Part 2. Synthesis and in vitro Antimicrobial Evaluation of 3-Chloro-4-carbamoyl-5-aryl-6-methyl-pyridazine N-Oxides." ChemInform 28, no. 36 (2010): no. http://dx.doi.org/10.1002/chin.199736171.

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44

Bonacorso, Helio G., Melissa B. Rodrigues, Sarah C. Feitosa, et al. "Synthesis and antimicrobial screening of 2-alkyl(aryl)-7-chloro-6-fluoro-4-(trifluoromethyl)-quinolines and their phenylacetylene derivatives, promoted by Sonogashira cross-coupling reaction." Journal of Fluorine Chemistry 205 (January 2018): 49–57. http://dx.doi.org/10.1016/j.jfluchem.2017.11.014.

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Sarveswari, S., and V. Vijayakumar. "A rapid microwave assisted synthesis of 1-(6-chloro-2-methyl-4-phenylquinolin-3-yl)-3-(aryl)prop-2-en-1-ones and their anti bacterial and anti fungal evaluation." Arabian Journal of Chemistry 9 (September 2016): S35—S40. http://dx.doi.org/10.1016/j.arabjc.2011.01.032.

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46

Dimukhametov, M. N., G. A. Ivkova, V. F. Mironov, P. P. Onys’ko, Yu V. Rassukanaya, and R. Z. Musin. "Reaction of 2-chloro-1,3,2-benzodioxaphosphinin-4-one with 2-(arylmethylideneamino)phenols. Stereoselective formation of 10-aryl-3,4 : 8,9-dibenzo-5,7-dioxa-1-aza-6-phosphabicyclo[4.3.1]decane-2,6-diones." Russian Journal of Organic Chemistry 50, no. 4 (2014): 605–7. http://dx.doi.org/10.1134/s1070428014040290.

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47

Cox, Philip J., Dimitrios Kechagias, and Orla Kelly. "Conformations of substituted benzophenones." Acta Crystallographica Section B Structural Science 64, no. 2 (2008): 206–16. http://dx.doi.org/10.1107/s0108768108000232.

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The inclination of the two aryl rings (ring twists) in a series of benzophenone molecules has been examined. For each structure the dihedral angle (between the planes of the two sets of six aromatic C atoms) relates to both the steric considerations of the single molecule and the packing forces related to the crystal structure. Six new benzophenone structures are incorporated into the study including 2,2′-dihydroxy-4,4′-dimethoxybenzophenone (I), C15H14O5, that appears to have the smallest reported twist angle, 37.85 (5)°, of any substituted benzophenone reported to date. Three further benzoph

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48

Desai, N. C., and Amit M. Dodiya. "Conventional and microwave techniques for the synthesis and antimicrobial studies of novel 1-[2-(2-chloro-6-methyl(3-quinolyl))-5-(4-nitrophenyl)-(1,3,4-oxadiazolin-3-yl)]-3-(aryl)prop-2-en-1-ones." Arabian Journal of Chemistry 9 (September 2016): S379—S387. http://dx.doi.org/10.1016/j.arabjc.2011.05.004.

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49

Sharma, Pratibha, Ashok Kumar, Shikha Sharma, and Nilesh Rane. "Studies on synthesis and evaluation of quantitative structure–activity relationship of 5-[(3′-chloro-4′,4′-disubstituted-2-oxoazetidinyl)(N-nitro)amino]-6-hydroxy-3-alkyl/aryl[1,3]azaphospholo[1,5-a]pyridin-1-yl-phosphorus dichlorides." Bioorganic & Medicinal Chemistry Letters 15, no. 4 (2005): 937–43. http://dx.doi.org/10.1016/j.bmcl.2004.12.050.

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50

Monkowius, Uwe, Manfred Zabel, Michel Fleck, and Hartmut Yersin. "Gold(I) Complexes Bearing P∩N-Ligands: An Unprecedented Twelve-membered Ring Structure Stabilized by Aurophilic Interactions." Zeitschrift für Naturforschung B 64, no. 11-12 (2009): 1513–24. http://dx.doi.org/10.1515/znb-2009-11-1235.

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The P∩N-ligands Ph2Pqn, 1, Ph2 Piqn, 2, Ph2 Ppym, 3, and the As∩N-ligands Ph2Asqn, 4, Ph2Asiqn, 5, (Ph = phenyl, qn = 8-quinoline, iqn = 1-isoquinoline, pym = 2-pyrimidine) have been synthesized, the ligands 2 and 5 for the first time. Their ligand properties were probed by the synthesis of gold(I) complexes. Reaction with (tht)AuCl (tht = tetrahydrothiophene) yielded the chlorogold complexes Ph2RP-Au-Cl (R = qn, 6; iqn, 7; pym, 8) and Ph2RAs-Au-Cl (R = qn, 9; iqn, 10) in high yields. Further treatment of 7 and 8 with one equivalent of AgBF4 provided the complexes [(Ph2Piqn)Au]BF4, 11, [(Ph2Pp

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