Relevant bibliographies by topics / 2-azabicyclo[3.3.1]octane

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Academic literature on the topic '2-azabicyclo[3.3.1]octane'

Author: Grafiati
Published: 9 March 2023

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Journal articles on the topic "2-azabicyclo[3.3.1]octane"

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Kumaran, D., M. N. Ponnuswamy, G. Shanmugam, S. Ponnuswamy, R. Jeyaraman, K. Shivakumar, and H. K. Fun. "Molecular structures and conformations of three 3-azabicyclononanes." Acta Crystallographica Section B Structural Science 55, no. 5 (October 1, 1999): 793–98. http://dx.doi.org/10.1107/s0108768199005273.

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The structure, conformation, molecular geometry and the mode of packing of 7-tert-butyl-N-methyl-2,4-diphenyl-3-azabicyclo[3.3.1]nonane (C25H33N; MTABN), N-acetyl-2,4-diphenyl-3-azabicyclo[3.3.1]nonane (C22H25NO; AABN) and N-methyl-2,4-bis(2-methylphenyl)-3-azabicyclo[3.3.1]nonan-9-ol (C23H29NO; MHABN) are presented. The compounds MTABN and MHABN crystallize in monoclinic space groups, whereas AABN is orthorhombic. In each of the three structures, the bicyclic ring system adopts a chair–chair conformation and the phenyl rings are in equatorial orientation with respect to the piperidine ring. In AABN, apart from the van der Waals forces, weak intermolecular C—H...O type interactions are involved in the packing.
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Bonjoch, Josep, Nuria Casamitjana, Josefina Quirante, Antoni Torrens, Anna Paniello, and Joan Bosch. "Functionalized 2-azabicyclo[3.3.1] nonanes. vii." Tetrahedron 43, no. 2 (January 1987): 377–81. http://dx.doi.org/10.1016/s0040-4020(01)89966-x.

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Bonjoch, Josep, Faïza Diaba, and Ben Bradshaw. "Synthesis of 2-Azabicyclo[3.3.1]nonanes." Synthesis 2011, no. 07 (February 3, 2011): 993–1018. http://dx.doi.org/10.1055/s-0030-1258420.

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Parthiban, P., V. Ramkumar, Min Sung Kim, Se Mo Son, and Yeon Tae Jeong. "2,4-Bis(2-methoxyphenyl)-3-azabicyclo[3.3.1]nonan-9-one." Acta Crystallographica Section E Structure Reports Online 65, no. 6 (May 23, 2009): o1383. http://dx.doi.org/10.1107/s1600536809018686.

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In the title compound, C22H25NO3, the molecule has a pseudo-mirror plane. The structure is a positional isomer of 2,4-bis(4-methoxyphenyl)-3-azabicyclo[3.3.1]nonan-9-one [Cox, McCabe, Milne & Sim (1985).J. Chem. Soc. Chem. Commun.pp. 626–628]. The 3-azabicyclo[3.3.1]nonan-9-one moiety adopts a double chair conformation with equatorial orientations of both 2-methoxyphenyl substituents on either side of the secondary amino group. The benzene rings are oriented at an angle of 33.86 (4)° with respect to each other and the methoxy groups point towards the carbonyl group. The crystal structure is stabilized by intermolecular N—H...π interactions.
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Rao, T. N., Y. Prasanthi, Parvatamma Botsa, G. Kumara, and K. A. Rao. "A NEW METHOD DEVELOPMENT AND VALIDATION FOR RELATED SUBSTANCES OF GRANISETRON IN ACTIVE PHARMA INGREDIENT BY HPLC." INDIAN DRUGS 54, no. 07 (July 28, 2017): 52–59. http://dx.doi.org/10.53879/id.54.07.10746.

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A simple and inexpensive method was developed using high performance liquid chromatography with PDA detection for determination of granisetron hydrochloride and related impurities (2-methyl-N- [(1R,3r,5S)-9-methyl-9-azabicyclo[3.3.1]non-3-yl]-2H-indazole-3-carboxamide, 1-Methyl-N-[(1R,3r,5S)- 9-methyl-9-azabicyclo[3.3.1]non-3-yl]-1H-indazole-3-carboxamide hydrochloride, N-[(1R,3r,5S)-9- azabicyclo[3.3.1]non-3-yl]-1-methyl-1H-indazole-3-carboxamide and 1-methyl-1H-indazole-3-carboxylic acid. The chromatographic separations were achieved on (250×4.6 mm), 5.0 μm make: Waters, Symmetry Shield C8 column employing acetonitrile: 2% V/V H3PO4 in MilliQ water + 0.1% V/V hexylamine in water, 800:200 V/V (pH adjusted to 7.5 using triethylamine) mobile phase with isocratic programme. A flow rate of 1.5 mL/min was chosen. Four impurities were eluted within 20 minutes. The column temperature was maintained at 40°C and a detector wavelength of 300 nm was employed. The method was successfully validated by establishing system suitability, specificity, linearity, accuracy, limit of detection and limit of quantification.
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Eckermann, Ruben, Michael Breunig, and Tanja Gaich. "Formal total synthesis of (±)-strictamine – the [2,3]-Stevens rearrangement for construction of octahydro-2H-2,8-methanoquinolizines." Chemical Communications 52, no. 76 (2016): 11363–65. http://dx.doi.org/10.1039/c6cc06125g.

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Liu, Yan-Qing, He Liu, Bo-hua Zhong, Yu-Lin Deng, and Ke-liang Liu. "Synthesis and Crystal Structure of (9s)-N-methyl-3-azabicyclo[3.3.1] nonan-9-yl (cyclopentyl)(hydroxy)(2-thienyl)Acetate Hydrochloride." Journal of Chemical Research 2005, no. 7 (July 2005): 436–37. http://dx.doi.org/10.3184/030823405774309041.

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(9s)-N-methyl-3-azabicyclo[3.3.1]nonan-9-yl (cyclopentyl)(hydroxy)(2-thienyl)acetate hydrochloride, a more effective muscarinic receptor antagonist, was synthesised and its crystal structure elucidated by X-ray crystallography.
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Carman, Raymond M., and Roger P. C. Derbyshire. "Azacineole (1,3,3-Trimethyl-2-azabicyclo[2.2.2]octane)." Australian Journal of Chemistry 56, no. 4 (2003): 319. http://dx.doi.org/10.1071/ch02189.

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Grygorenko, Oleksandr, Maksym Kurkunov, Igor Levandovskiy, and Andriy Tymtsunik. "Synthesis of 2-Azabicyclo[n.2.0]alkane-Derived Building Blocks." Synthesis 50, no. 10 (March 29, 2018): 1973–78. http://dx.doi.org/10.1055/s-0037-1609434.

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An approach to 2-azabicyclo[n.2.0]alkane derivatives (n = 1, 2), which relies on a tandem Strecker reaction–intramolecular nucleophilic cyclization (STRINC) sequence of the corresponding 2-(ω-chloroalkyl)cyclobutanones (in turn prepared by [2+2] cycloaddition of keteniminium salts and ethylene) is described. The utility of the method is demonstrated by multigram syntheses of bicyclic proline analogues, monoprotected diamines, as well as parent 2-azabicyclo[4.2.0]octane.
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Bonjoch, Josep, Faiza Diaba, and Ben Bradshaw. "ChemInform Abstract: Synthesis of 2-Azabicyclo[3.3.1]nonanes." ChemInform 42, no. 35 (August 4, 2011): no. http://dx.doi.org/10.1002/chin.201135229.

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Dissertations / Theses on the topic "2-azabicyclo[3.3.1]octane"

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Masri, Fadi. "Synthèse de dérivés fonctionnalisés du 8-méthyl-8-azabicyclo[3. 2. 1]octane : vers de nouveaux marqueurs technétiés des transporteurs des monoamines." Université Joseph Fourier (Grenoble), 2003. http://www.theses.fr/2003GRE10029.

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JONAS, Hendrik. "Stereoselective Synthesis and Pharmacological Evaluation of 2,4-Bridged Piperidine Derivatives Designed to Activate the κ-Opioid Receptor." Doctoral thesis, Università degli Studi di Palermo, 2021. http://hdl.handle.net/10447/518592.

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Mehmandoust, Maryam. "Synthèse de dihydro-1, 2 pyridines et d'équivalents de sels de dihydro-2, 5 pyridinium à partir d'amines primaires chirales : application à la synthèse énantiosélective de dérivés d'isoquinuclidines et de pipéridines 2-substituées." Paris 11, 1989. http://www.theses.fr/1989PA112254.

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Une méthode générale de synthèse des sels de pyridinium N-substitués par différents auxiliaires chiraux, une application de la réaction de Zincke, à partir des amines primaires chirales correspondantes, est décrite. Par réduction au borohydrure de sodium en milieu alcalin, ces sels de pyridinium conduisent aux dihydro-1,2 pyridines correspondantes dont les réactions de cycloaddition avec l'acrylate de méthyle ont été étudiées. Des composés azabicyclo[2. 2. 2]octane (isoquinuclidines), dont la configuration absolue a été établie, sont obtenus avec des e. D. De 20 à 33% et une bonne pureté optique. La réduction des sels de pyridinium dérivés des aminoalcools tel que la (R)-phénylglycinol dans les mêmes conditions conduit aux intermédiaires de type oxazolidine équivalent stable d'un sel de dihydro-2,5 pyridinium. L'alkylation stéréosélective de ces derniers par les réactifs de Grignard, suivie de l'élimination de l’auxiliaire donne accès aux alkyl-2 tétrahydro-1,2,3,6 pyridines optiquement active. L'intérêt de cette méthode générale pour l'élaboration des squelettes pipéridiniques, est illustré par la synthèse de la (R)-(+)-anatabine ainsi que la (S)-(+)coniine
The reaction of chiral primary amines with 2,4-dinitro phenyl pyridinium chloride, according to Zincke's procedure, leads to chiral pyridinium salts which can be reduced with NaBH4 in an alkaline medium to the corresponding 1,2-dihydropyridines bearing the chiral substituent on the nitrogen. Cycloaddition reactions of these dihydropyridines with methyl acrylate give isoquinuclidines in 20-33% d. E. Absolute configuration of optically pure isoquinuclidines separated from this diastereoisomeric mixture is established. On the other hand, reduction of pyridinium salts derived from amino alcohols such as (R)-phenyl glycinol in the same conditions leads to new oxazolidine-type intermediates which can be considered as 2,5-dihydropyridinium salt equivalents. Stereoselective alkylation followed by removal of the chiral auxilliary provides a simple access to enantio­ merically pure 2-alkyl 1,2,3,6-tetrahydropyridines. The usefulness of this methodology for the construction of optically pure piperidine derivatives is illustrated by the synthesis of (R)-(+)-anatabine and (S)-(+)-coniine
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Book chapters on the topic "2-azabicyclo[3.3.1]octane"

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Morgan, Michael M., MacDonald J. Christie, Thomas Steckler, Ben J. Harrison, Christos Pantelis, Christof Baltes, Thomas Mueggler, et al. "Methyl (1R,2R,3S,5S)-3-(Benzoyloxy)-8-Methyl-8-Azabicyclo[3.2.1] Octane-2-Carboxylate." In Encyclopedia of Psychopharmacology, 758. Berlin, Heidelberg: Springer Berlin Heidelberg, 2010. http://dx.doi.org/10.1007/978-3-540-68706-1_3393.

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"Cocaine (3-benzoyloxy)-8methyl-8-azabicyclo[3.2.1]octane-2-carboxylic acid methyl ester)." In Encyclopedia of Genetics, Genomics, Proteomics and Informatics, 380. Dordrecht: Springer Netherlands, 2008. http://dx.doi.org/10.1007/978-1-4020-6754-9_3242.

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"Bicyclo[2.2.1]heptane-2,5-bis[ium] to 2-Oxa-4-azabicyclo[3.3.0]octane." In Substance Index, edited by Backes, Fröhlich, and Padeken. Stuttgart: Georg Thieme Verlag, 2000. http://dx.doi.org/10.1055/b-0035-114014.

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