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Journal articles on the topic '2-c]thiazoles'

Author: Grafiati

Published: 5 June 2025

Last updated: 1 August 2025

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1

Liu, Wei, Xin Yu, and Chunxiang Kuang. "Palladium-Catalyzed C-2 Selective Olefination of Thiazoles." Organic Letters 16, no. 6 (2014): 1798–801. http://dx.doi.org/10.1021/ol500542j.

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2

Shaaban, Khaled A., Mohamed Shaaban, Hafizur Rahman, et al. "Karamomycins A–C: 2-Naphthalen-2-yl-thiazoles from Nonomuraea endophytica." Journal of Natural Products 82, no. 4 (2019): 870–77. http://dx.doi.org/10.1021/acs.jnatprod.8b00928.

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3

Gogoi, Prasanta, Bappi Paul, Sukanya Hazarika, and Pranjit Barman. "Gold nanoparticle catalyzed intramolecular C–S bond formation/C–H bond functionalization/cyclization cascades." RSC Advances 5, no. 71 (2015): 57433–36. http://dx.doi.org/10.1039/c5ra10885c.

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An efficient synthesis of 2-(N-aryl)aminobenzo[d]-1,3-thiazoles via intramolecular C–S bond formation/C–H bond functionalization utilizing an unusual cocatalytic Au-NPs/KMnO<sub>4</sub> system under an oxygen atmosphere at 80 °C is presented.

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4

Shailendra, Tiwari, and Nizamuddin. "Synthesis and fungicidal activities of some 2-substituted arylamino-5-(2' -furyl)- 1,3,4-thiadiazolo[3,2-c]thiazoles and 5-substituted aryl-2-substituted arylamino-1 ,3 ,4-thiadiazolo [3 ,2-c ]thiazoles." Journal of Indian Chemical Society Vol. 90, May 2013 (2013): 679–83. https://doi.org/10.5281/zenodo.5772308.

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Department of Chemistry, University of Allahabad, Allahabad-211 002, Uttar Pradesh, India <em>E-mail</em> : drshailendratiwariau@gmail. com Department of Chemistry, DDU Gorakhpur University, Gorakhpur-273 009, Uttar Pradesh, India <em>E-mail</em> : prnukhan@gmail.com <em>Manuscript received 13 December 2011, revised 14 May 2012, accepted 11 July 2012</em> Several 2-substituted arylamino-5-(2<em>'</em>-furyl)-1,3,4-thiadiazolo[3,2-c]thiazoles have been synthesised by cyclisation of 3-substituted aryl thiocarbanilido-2-(2<em>'</em> -furyl)thiazolidin-4-ones with conc. H<sub>2</sub>SO<sub

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5

Liu, Wei, Xin Yu, and Chunxiang Kuang. "ChemInform Abstract: Palladium-Catalyzed C-2 Selective Olefination of Thiazoles." ChemInform 45, no. 37 (2014): no. http://dx.doi.org/10.1002/chin.201437148.

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6

Yan, Kelu, Daoshan Yang, Wei Wei, Pengfei Sun, Yunxiang Lu, and Hua Wang. "A copper-catalyzed cascade reaction of o-bromoarylisothiocyanates with isocyanides leading to benzo[d]imidazo[5,1-b]thiazoles under ligand-free conditions." Organic Chemistry Frontiers 3, no. 5 (2016): 556–60. http://dx.doi.org/10.1039/c6qo00030d.

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7

Nedolya, Nina, Boris Trofimov, Olga Tarasova, and Alexander Albanov. "tert-Butoxide-Assisted Structural Transformation of 2-Aza-1,3,5-trienes: Fast Track to 5-Ethynyl-2-vinyl- and 2,5-Divinyl-1,3-thiazoles." Synthesis 50, no. 21 (2018): 4313–24. http://dx.doi.org/10.1055/s-0037-1609561.

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Treatment of 2-aza-1,3,5-trienes, methyl N-[2-alkoxy-1-(prop-2-ynylsulfanyl)buta-1,3-dienyl]- and methyl N-[1-(allylsulfanyl)-2-alkoxybuta-1,3-dienyl]iminoformates, which are easily obtained from lithiated alkoxyallenes, methoxymethyl isothiocyanate, and propargyl or allyl bromide, with t-BuOK or t-BuONa in DMSO–THF results in the formation of 5-ethynyl-2-vinyl- and 2,5-divinyl-1,3-thiazoles. The reactions are realized under mild conditions at ca. –30 °C for 30 minutes. An unprecedented structural transformation of the (prop-2-ynylsulfanyl)- and (allylsulfanyl)-substituted 2-aza-1,3,5-trienes

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8

Luo, Puying, Qiuping Ding, Yuanyuan Ping, and Jianan Hu. "Regioselective ortho-trifluoromethylthiolation of 2-arylbenzo[d]thiazole via tandem substrate-assisted C–H iodination and trifluoromethylthiolation." Organic & Biomolecular Chemistry 14, no. 10 (2016): 2924–29. http://dx.doi.org/10.1039/c6ob00005c.

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A mild and efficient tandem benzo[d]thiazole directed C–H iodination and trifluoromethylthiolation for the synthesis ofortho-trifluoromethylthiolated 2-arylbenzo[d]thiazoles have been developed using AgSCF<sub>3</sub>as a coupling partner.

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9

Zi, You, Konrad Wagner, Fritz Schömberg, and Ivan Vilotijevic. "Selective C–H chalcogenation of thiazoles via thiazol-2-yl-phosphonium salts." Organic & Biomolecular Chemistry 18, no. 27 (2020): 5183–91. http://dx.doi.org/10.1039/d0ob00684j.

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Medicinally relevant substituted benzothiazoles and thiazoles are prepared under mild conditions by a regioselective C2–H chalcogenation via preparation of the phosphonium salt and the subsequent reaction with S- and Se-centered nucleophiles.

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10

Shaik, Siddiq Pasha, Faria Sultana, A. Ravikumar, Satish Sunkari, Abdullah Alarifi, and Ahmed Kamal. "Regioselective oxidative cross-coupling of benzo[d]imidazo[2,1-b]thiazoles with styrenes: a novel route to C3-dicarbonylation." Organic & Biomolecular Chemistry 15, no. 36 (2017): 7696–704. http://dx.doi.org/10.1039/c7ob01778b.

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Iodine promoted metal-free domino protocol has been developed for the C3-dicarbonylation of benzo[d]imidazo[2,1-b]thiazoles (IBTs) with styrenes via oxidative cleavage of the C(sp<sup>2</sup>)–H bond, followed by C3-nucleophilic attack of IBT and oxidation.

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11

Li, Xiangnan, Cheng Li, Bing Yin, et al. "DDQ-Induced Dehydrogenation of Heterocycles for CC Double Bond Formation: Synthesis of 2-Thiazoles and 2-Oxazoles." Chemistry - An Asian Journal 8, no. 7 (2013): 1408–11. http://dx.doi.org/10.1002/asia.201300267.

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12

Tiwari, Shailendra, and Nizamuddin Nizamuddin. "ChemInform Abstract: Synthesis and Fungicidal Activities of Some 2-Substituted Arylamino-5-(2′-furyl)-1,3,4-thiadiazolo[3,2-c]thiazoles and 5-Substituted Aryl-2-substituted Arylamino-1,3,4-thiadiazolo[3,2-c]thiazoles." ChemInform 44, no. 47 (2013): no. http://dx.doi.org/10.1002/chin.201347124.

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13

Özbey, Süheyla, and Asiye Meriç. "3,4-Di-p-tolyl-6,7-dihydroimidazo[2,1-b][1,3]thiazole." Acta Crystallographica Section E Structure Reports Online 62, no. 7 (2006): o2717—o2719. http://dx.doi.org/10.1107/s160053680602099x.

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The title compound, C19H18N2S, is a member of a new series of 2,3-dihydroimidazo[2,1-b][1,3]thiazoles and was obtained from 4,5-di-p-tolyl-1,3-dihydroimidazole-2-thione and 1-bromo-2-chloroethane. The thiazole ring adopts an envelope conformation; the plane through N, S and two C atoms makes a dihedral angle of 2.35 (3)° with the fused imidazole ring. The tolyl groups are essentially planar.

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14

Huang, Guoli, Hongsheng Sun, Xiaojie Qiu, et al. "Ligand-Free Copper-Catalyzed Regioselective C-2 Arylation of Imidazo[2,1-b]thiazoles." Organic Letters 13, no. 19 (2011): 5224–27. http://dx.doi.org/10.1021/ol2021109.

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15

Li, Xiangnan, Cheng Li, Bing Yin, et al. "ChemInform Abstract: DDQ-Induced Dehydrogenation of Heterocycles for C-C Double Bond Formation: Synthesis of 2-Thiazoles and 2-Oxazoles." ChemInform 44, no. 46 (2013): no. http://dx.doi.org/10.1002/chin.201346125.

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16

Zhou, Xiaoli, Puying Luo, Ling Long, Meizhen Ouyang, Xiaoyan Sang, and Qiuping Ding. "Ru-catalyzed direct C–H amidation of 2-arylbenzo[d]thiazoles with sulfonyl azides." Tetrahedron 70, no. 38 (2014): 6742–48. http://dx.doi.org/10.1016/j.tet.2014.07.076.

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17

Ding, Qiuping, Huafang Ji, Ziyi Nie, Qin Yang, and Yiyuan Peng. "Palladium-catalyzed C–H bond functionalization/oxidative acyloxylation of 2-aryl-benzo[d]thiazoles." Journal of Organometallic Chemistry 739 (September 2013): 33–39. http://dx.doi.org/10.1016/j.jorganchem.2013.04.026.

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18

Satheesh, Sandhya, Akhila Radha, Krishnapriya Girija, Kallikat Rajasekharan та Priya Maheswari. "Hindered phenolic aminothiazoles - synthesis, α-glucosidase, α-amylase inhibitory and antioxidant activities". Journal of the Serbian Chemical Society 82, № 10 (2017): 1087–95. http://dx.doi.org/10.2298/jsc161005084s.

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Base-catalysed heterocyclization of either N-aryl-N'-[imino(nitroamino) methyl]thioureas or N-aryl-N'-cyanothioureas by reaction with 2-bromo- 1-(2,6-di-t-butyl-4-hydroxyphenyl)ethanone afforded 4-amino-2-(arylamino)- -5-(3,5-di-t-butyl-4-hydroxybenzoyl)thiazoles, designed as molecular hybrids of hindered phenolic and 2-aminothiazole moieties. These compounds were screened for their inhibition activity on carbohydrate hydrolyzing enzymes. Thus, [4-amino-2-(phenylamino)-5-thiazolyl](3,5-di-t-butyl-4-hydroxyphenyl)- methanone exhibited ?-glucosidase inhibition activity with an IC50 value of 117

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19

Huang, Guoli, Hongsheng Sun, Xiaojie Qiu, et al. "ChemInform Abstract: Ligand-Free Copper-Catalyzed Regioselective C-2 Arylation of Imidazo[2,1-b]thiazoles." ChemInform 43, no. 6 (2012): no. http://dx.doi.org/10.1002/chin.201206122.

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20

De, Surya K., Li-Hsing Chen, John L. Stebbins, et al. "Discovery of 2-(5-nitrothiazol-2-ylthio)benzo[d]thiazoles as novel c-Jun N-terminal kinase inhibitors." Bioorganic & Medicinal Chemistry 17, no. 7 (2009): 2712–17. http://dx.doi.org/10.1016/j.bmc.2009.02.046.

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21

HIMATKUMAR, V. PATEL, and S. FERNANDES P. "A Novel Synthesis of 2-Amino-4-5-disubstituted-thiazole and 2-Amino-5-hydro-4-arylazo-6-arylthiazolo[5,4-c ]- pyridazin-5-ones and their Biological Properties." Journal of Indian Chemical Society Vol. 66, May 1989 (1989): 327–29. https://doi.org/10.5281/zenodo.5995551.

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N. S. R. Laboratory, Department of Chemistry. St. Xavier's College, Bombay-400 001 <em>Manuscript received 22 September 1988, revised 7 December 1988. accepted 21 February 1989</em> Ethyl -\(\gamma\)-bromo-\(\propto\)-arylazoacetoacetates (1) were reacted with thiourea in DMF to give the correspondiag ethyl 2-amino-\(\propto\)-arylazo-4-thiazolylacetates (2). which when coupled with arene diazonium chloride in presence of sodium acetate, gave the corresponding ethyl 2·amino-\(\propto\)-arylazo-5-(arylazo)-4-thiazolylacetates (3-5). The thiazoles (3-5) when cyclised in pres

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22

Nguyễn, Thiên Thuý Trang, Jean-François Longevial, and Stéphanie Hesse. "Synthesis of Thiazolo[5,4-d]thiazoles in an Eco-Friendly L-Proline–Ethylene Glycol Mixture." Molecules 30, no. 4 (2025): 938. https://doi.org/10.3390/molecules30040938.

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The hazardousness of solvents used in synthetic organic chemistry is well established. In this context, it is relevant to search for safer and greener alternatives. Within the last decades, deep eutectic solvents have been considered as possible and promising alternatives. Consequently, this study aims at using deep eutectic solvents to synthesize an emerging class of heteroaromatic compounds named thiazolo[5,4-d]thiazoles, for which interest is growing in the field of organics, electronics, and biology. To address this challenge, we developed a straightforward synthetic protocol consisting of

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23

Zhou, Xiaoli, Puying Luo, Ling Long, Meizhen Ouyang, Xiaoyan Sang, and Qiuping Ding. "ChemInform Abstract: Ru-Catalyzed Direct C-H Amidation of 2-Arylbenzo[d]thiazoles with Sulfonyl Azides." ChemInform 46, no. 6 (2015): no. http://dx.doi.org/10.1002/chin.201506171.

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24

Ding, Qiuping, Huafang Ji, Ziyi Nie, Qin Yang, and Yiyuan Peng. "ChemInform Abstract: Palladium-Catalyzed C-H Bond Functionalization/Oxidative Acyloxylation of 2-Aryl-benzo[d]thiazoles." ChemInform 44, no. 46 (2013): no. http://dx.doi.org/10.1002/chin.201346127.

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25

Soares, Maria I. L., Susana M. M. Lopes, Pedro F. Cruz, Rui M. M. Brito, and Teresa M. V. D. Pinho e Melo. "Flash vacuum pyrolysis of 2,2-dioxo-1H,3H-pyrrolo[1,2-c]thiazoles and 2-vinyl-1H-pyrroles." Tetrahedron 64, no. 41 (2008): 9745–53. http://dx.doi.org/10.1016/j.tet.2008.07.079.

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26

Hoarau, Christophe, Pierrik Lassalas, and Francis Marsais. "DMAP-Catalyzed Regel-Type Direct C-2 (Hetero)Aroylation of Oxazoles and Thiazoles Derivatives with Acid Chlorides." Synlett 24, no. 17 (2013): 2233–40. http://dx.doi.org/10.1055/s-0033-1339858.

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27

Ghosh, Prasanjit, Gautam Chhetri, Anirban Mandal, Yu Chen, William H. Hersh, and Sajal Das. "C(sp²)–H selenylation of substituted benzo[4,5]imidazo[2,1-b]thiazoles using phenyliodine(iii)bis(trifluoroacetate) as a mediator." RSC Advances 14, no. 7 (2024): 4462–70. http://dx.doi.org/10.1039/d4ra00057a.

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A metal-free regioselective C–H selenylation of substituted benzo[4,5]imidazo[2,1-b]thiazoles is devised to prepare structurally diverse selenoether derivatives in good to excellent yields. The reaction is scalable and follows radical pathways.

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28

Wang, Yishou, Shichen Li, Xinfeng Wang, Yiming Yao, Lei Feng, and Chen Ma. "A multi pathway coupled domino strategy: I₂/TBHP-promoted synthesis of imidazopyridines and thiazoles via sp³, sp² and sp C–H functionalization." RSC Advances 12, no. 10 (2022): 5919–27. http://dx.doi.org/10.1039/d1ra07438e.

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One-pot, multi-pathway, and atom economic synthesis of imidazoles and thiazoles has been achieved. In the catalytic system, I2/TBHP as an initiator and oxidant is used to realize sp3, sp2 and sp C–H functionalization.

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29

Ding, Qiuping, Xiaoli Zhou, Shouzhi Pu, and Banpeng Cao. "Rhodium-catalyzed ortho-selective C–H halogenation of 2-arylbenzo[d]thiazoles using N-halosuccinimides as halogen sources." Tetrahedron 71, no. 16 (2015): 2376–81. http://dx.doi.org/10.1016/j.tet.2015.03.004.

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30

Bhanage, Bhalchandra, and Ashok Khemnar. "Direct C-2 Acylation of Thiazoles with Aldehydes via Metal- and Solvent-Free C–H Activation in the Presence of tert-Butyl Hydroperoxide." Synlett 25, no. 01 (2013): 110–14. http://dx.doi.org/10.1055/s-0033-1340068.

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31

Lassalas, Pierrik, Francis Marsais, and Christophe Hoarau. "ChemInform Abstract: DMAP-Catalyzed Regel-Type Direct C-2 (Hetero)Aroylation of Oxazoles and Thiazoles Derivatives with Acid Chlorides." ChemInform 45, no. 11 (2014): no. http://dx.doi.org/10.1002/chin.201411080.

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32

Luna, Isadora Silva, Rayssa Marques Duarte da Cruz, Ryldene Marques Duarte da Cruz, Rodrigo Santos Aquino de Araújo, and Francisco Jaime Bezerra Mendonça-Junior. "1,4-Dithiane-2,5-diol: A Versatile Synthon for the Synthesis of Sulfur-containing Heterocycles." Current Organic Synthesis 15, no. 8 (2018): 1026–42. http://dx.doi.org/10.2174/1570179415666180821154551.

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Background: 1,4-Dithiane-2,5-diol (1,4-DTD) is the stable dimer of α-mercapto acetaldehyde. This commercially available ambidentade compound is characterized as having in its chemical structure one group that acts as an electrophile and another that acts as a nucleophile, this permits its use as versatile and efficient synthon in synthetic heterocycle procedures. Objective: The aim of this review is to present synthetic applications of 1,4-DTD in heterocyclic chemistry and their applicability to the synthesis of bioactive compounds. Conclusion: Gewald reactions to obtain C-4 and C-5 unsubstitu

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33

Rajaguru, Kandasamy, Arumugam Mariappan, Ramachandran Manjusri, Shanmugam Muthusubramanian, and Nattamai Bhuvanesh. "An efficient desulfitative C–C cross coupling of fused thiazolidine-2-thione with boronic acids and boronic acid pinacol esters: formation of fused thiazoles." RSC Advances 5, no. 105 (2015): 86832–39. http://dx.doi.org/10.1039/c5ra17827d.

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An efficient Pd(0)-catalyzed Cu(i)-mediated desulfitative C–C cross-coupling of benzo-fused thiazolidine-2-thione with boronic acids under neutral conditions and boronic acid pinacol esters under basic conditions has been demonstrated.

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34

Slyvka, N. Yu, L. M. Saliyeva, V. I. Zhylko, V. M. Tkachuk, and M. V. Vovk. "Synthesis and antioxidant activity of new 2-(2-oxoindoline-3-ylydene) substituted 5,6-dihydroimidazo[2,1-b]thiazolones and 6,7-dihydro-thiazolo[3,2-a]pyrimidinones." Voprosy Khimii i Khimicheskoi Tekhnologii, no. 1 (February 2025): 71–79. https://doi.org/10.32434/0321-4095-2025-158-1-71-79.

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The paper presents the results of the study on the interaction of 5,6-dihydroimidazo[2,1-b]thiazoles and 6,7-dihydrothiazolo[3,2-a]pyrimidines with isatin derivatives. It was established that the condensation of the indicated reagents occurs selectively upon heating and without the use of a catalyst with the formation of addition products, 2-(2-oxoindolin-3-ylidene)-5,6-dihydroimidazo[2,1-b]thiazole-3(2H)-ones 6a–d and 2-(2-oxoindolin-3-ylidene)-6,7-dihydro-2H-thiazolo[3,2-a]pyrimidin-3(5H)-ones 7a–c, the structure of which was rigorously proven by 1H NMR (13C) spectroscopy and chromatography-

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35

Arcadi, Antonio, Orazio A. Attanasi, Barbara Guidi, Elisabetta Rossi, and Stefania Santeusanio. "Pyrido[3,4-c]Thiazoles through Combined Palladium-Catalysed Coupling of 2-Substituted-5-acetyl-4-thiazolyltriflates with Alkynes/Annulation Reactions." Chemistry Letters 28, no. 1 (1999): 59–60. http://dx.doi.org/10.1246/cl.1999.59.

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36

Ding, Qiuping, Xiaoli Zhou, Shouzhi Pu, and Banpeng Cao. "ChemInform Abstract: Rhodium-Catalyzed ortho-Selective C-H Halogenation of 2-Arylbenzo[d]thiazoles Using N-Halosuccinimides as Halogen Sources." ChemInform 46, no. 30 (2015): no. http://dx.doi.org/10.1002/chin.201530051.

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37

AGRAWAL, T., N. TIWARI, M. H. KHAN, and NIZAMUDDIN NIZAMUDDIN. "ChemInform Abstract: Synthesis of Some 2′-Aryl/Aryloxymethylspiro(cyclohexane-1,5′-(5H)(1,3, 4)oxadiazolo-(3,2-c)thiazoles) as Possible Fungicides." ChemInform 25, no. 40 (2010): no. http://dx.doi.org/10.1002/chin.199440150.

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38

Khemnar, Ashok B., and Bhalchandra M. Bhanage. "ChemInform Abstract: Direct C-2 Acylation of Thiazoles with Aldehydes via Metal- and Solvent-Free C-H Activation in the Presence of tert-Butyl Hydroperoxide." ChemInform 45, no. 24 (2014): no. http://dx.doi.org/10.1002/chin.201424140.

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39

Wang, Jian, Ziyi Nie, Yan Li, et al. "Pd-catalysed ortho-C-H Acylation/cross Coupling of 2-arylbenzo[d]thiazoles with Aldehydes Using tert-butyl Hydroperoxide as Oxidant." Journal of Chemical Research 37, no. 5 (2013): 263–67. http://dx.doi.org/10.3184/174751913x13639769724276.

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40

Gottumukkala, Aditya L., and Henri Doucet. "Activated Aryl Chlorides: Useful Partners for the Coupling with 2-Substituted Thiazoles in the Palladium-Catalysed C-H Activation/Functionalisation Reaction." European Journal of Inorganic Chemistry 2007, no. 23 (2007): 3629–32. http://dx.doi.org/10.1002/ejic.200700420.

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41

Rajaguru, Kandasamy, Arumugam Mariappan, Ramachandran Manjusri, Shanmugam Muthusubramanian, and Nattamai Bhuvanesh. "ChemInform Abstract: An Efficient Desulfitative C-C Cross Coupling of Fused Thiazolidine-2-thione with Boronic Acids and Boronic Acid Pinacol Esters: Formation of Fused Thiazoles." ChemInform 47, no. 10 (2016): no. http://dx.doi.org/10.1002/chin.201610149.

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42

Arcadi, Antonio, Orazio A. Attanasi, Barbara Guidi, Elisabetta Rossi, and Stefania Santeusanio. "ChemInform Abstract: Pyrido[3,4-c]thiazoles Through Combined Palladium-Catalyzed Coupling of 2-Substituted-5-acetyl-4-thiazolyltriflates with Alkynes/Annulation Reactions." ChemInform 30, no. 23 (2010): no. http://dx.doi.org/10.1002/chin.199923171.

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43

Liu, Deming, Qiuping Ding, Yang Fu, Zhibin Song, and Yiyuan Peng. "Rh-Catalyzed C–H Amidation of 2-Arylbenzo[d]thiazoles: An Approach to Single Organic Molecule White Light Emitters in the Solid State." Organic Letters 21, no. 8 (2019): 2523–27. http://dx.doi.org/10.1021/acs.orglett.9b00115.

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44

Aridoss, G., S. Amirthaganesan, M. S. Kim, J. T. Kim, and Yeon Tae Jeong. "Synthesis, spectral and biological evaluation of some new thiazolidinones and thiazoles based on t-3-alkyl-r-2,c-6-diarylpiperidin-4-ones." European Journal of Medicinal Chemistry 44, no. 10 (2009): 4199–210. http://dx.doi.org/10.1016/j.ejmech.2009.05.015.

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45

Wang, Jian, Ziyi Nie, Yan Li, et al. "ChemInform Abstract: Pd-Catalyzed ortho-C-H Acylation/Cross Coupling of 2-Arylbenzo[d]thiazoles with Aldehydes Using tert-Butyl Hydroperoxide as Oxidant." ChemInform 44, no. 42 (2013): no. http://dx.doi.org/10.1002/chin.201342123.

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46

Marc, Gabriel, Anca Stana, Ana Horiana Franchini, et al. "Phenolic Thiazoles with Antioxidant and Antiradical Activity. Synthesis, In Vitro Evaluation, Toxicity, Electrochemical Behavior, Quantum Studies and Antimicrobial Screening." Antioxidants 10, no. 11 (2021): 1707. http://dx.doi.org/10.3390/antiox10111707.

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Oxidative stress represents the underlying cause of many chronic diseases in human; therefore, the development of potent antioxidant compounds for preventing or treating such conditions is useful. Starting from the good antioxidant and antiradical properties identified for the previously reported Dihydroxy-Phenyl-Thiazol-Hydrazinium chloride (DPTH), we synthesized a congeneric series of phenolic thiazoles. The radical scavenging activity, and the antioxidant and chelation potential were assessed in vitro, a series of quantum descriptors were calculated, and the electrochemical behavior of the

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Herrera, Julian Hernández, Jimmy Morales, Kevin Steven Gómez Lara, Jhon Jairo Collazos Reina, Alvaro J. Avendaño, and Andrés Dector. "UV-vis Spectroelectrochemical In situ Study During the Electrochemical Oxidation of 2-Thiazolamine and 2-Oxazolamine." ECS Meeting Abstracts MA2022-02, no. 64 (2022): 2396. http://dx.doi.org/10.1149/ma2022-02642396mtgabs.

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Oxazoles and thiazoles are useful organic compounds in the pharmaceutical industry and agricultural chemistry. For example, the aminothiazole heterocycle system is a useful structural element in medical chemistry and has found wide applications. [1] In previous studies, our group has reported that he electroactivity of 2-aminothiazole and 2-aminooxazole derivate resides on the primary amine group in C-2 position in thiazolic and oxazolic ring respectively and the electron donor ability is mainly governed by 2-aminothiazole and 2-aminooxazole chemistry. [2] Preliminary results, however, have no

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Dondoni, Alessandro, Santiago Franco, Federico Junquera та ін. "Stereoselective Homologation–Amination of Aldehydes by Addition of Their Nitrones to C-2 Metalated Thiazoles—A General Entry to α-Amino Aldehydes and Amino Sugars". Chemistry - A European Journal 1, № 8 (1995): 505–20. http://dx.doi.org/10.1002/chem.19950010804.

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Ghorab, Mostafa M., Mansour S. Alsaid, Mohammed S. Al-Dosari, Fatma A. Ragab, Abdullah A. Al-Mishari, and Abdulaziz N. Almoqbil. "Novel quinolines carrying pyridine, thienopyridine, isoquinoline, thiazolidine, thiazole and thiophene moieties as potential anticancer agents." Acta Pharmaceutica 66, no. 2 (2016): 155–71. http://dx.doi.org/10.1515/acph-2016-0016.

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Abstract As a part of ongoing studies in developing new anticancer agents, novel 1,2-dihydropyridine 4, thienopyridine 5, isoquinolines 6–20, acrylamide 21, thiazolidine 22, thiazoles 23–29 and thiophenes 33–35 bearing a biologically active quinoline nucleus were synthesized. The structure of newly synthesized compounds was confirmed on the basis of elemental analyses and spectral data. All the newly synthesized compounds were evaluated for their cytotoxic activity against the breast cancer cell line MCF7. 2,3-Dihydrothiazole-5-carboxamides 27, 25, 4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxa

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Gomha, Sobhi M., Nahed A. Abd El-Ghany, Manal S. Ebaid, et al. "Eco-Friendly Synthesis of Thiazole Derivatives Using Recyclable Cross-Linked Chitosan Hydrogel Biocatalyst Under Ultrasonic Irradiation as Anti-Hepatocarcinogenic Agents." Catalysts 14, no. 12 (2024): 840. http://dx.doi.org/10.3390/catal14120840.

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In the current study, pyromellitimide benzoyl thiourea cross-linked chitosan (PIBTU-CS) hydrogel, was evaluated as a green biocatalyst for the efficient synthesis of novel thiazole derivatives. The PIBTU-CS hydrogel showcased key advantages, such as an expanded surface area and superior thermal stability, establishing it as a potent eco-friendly catalyst. By employing PIBTU-CS alongside ultrasonic irradiation, we successfully synthesized a series of novel thiazoles through the reaction of 2-(4-((2-carbamothioylhydrazineylidene)methyl)phenoxy)-N-(4-chlorophenyl)acetamide with a variety of hydra

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