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Journal articles on the topic '-(2-chlorophenyl)-1H-benzo[d]imidazole'

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Published: 4 June 2025

Last updated: 6 July 2025

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1

Singh, Ashok K., Snehlata Katheria, Amrendra Kumar, Asiff Zafri, and Mohd Arshad. "Design, Synthesis, Characterization and Antiproliferative Activities of Ru(II) Complexes of Substituted Benzimidazoles." Asian Journal of Chemistry 31, no. 10 (2019): 2311–18. http://dx.doi.org/10.14233/ajchem.2019.22162.

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Synthesis of [Ru(PPh3)2(BZM)2Cl2] (BZM= LS1, LS2, LS3, LS4 and LS5) where LS1=(1H-benzo[d] imidazole-2-yl)methanethiol, LS2 = 2-(4-bromobutyl)-1H-benzo[d] imidazole, LS3= 2-(4-nitrophenyl)-1H-benzo[d]imidazole, LS4 = 2-(4-chlorophenyl)-1H-benzo[d]imidazole and LS5= 4-(1H-benzo[d]imidazol-2-yl)aniline (BZM = benzimidazoles, PPh3 = triphenylphosphine) and metal complexes as MR, [ Ru (PPh3)4Cl2], MLS1, MLS2, MLS3, MLS4 and MLS5 for use as potential anticancer compounds have been investigated. The complexes have been characterized by elemental analysis, IR, multinuclear NMR, UV-visible and ESI-MS spectroscopic techniques. The geometries of all complexes have been optimized by using density functional theory (DFT). The cytotoxicity effects of MR, MLS2 and LS1 were also investigated on Human cervical carcinoma cells (HeLa) by MTT assay, ROS generation and nuclear apoptosis assay. The percent cell viability assessed by MTT assay suggested that the synthesized MR, MLS2 and LS1 significantly reduce the viability of HeLa cells, in a dose-dependent manner. The inhibitory concentration (IC50) of MR, MLS2 and LS1 against HeLa cells was found 90.8, 81.8 and 115 μM, respectively. These compounds also induced the over production of intracellular reactive oxygen species (ROS) as well as the condensed and fragmented nucleus, which supports the molecular mechanism of cell death by apoptosis. The investigations suggested that the compounds MR, MLS2 and LS1 induce the cell death in HeLa cells through apoptotic pathway.

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2

C., M. Mahalakshmi. "Synthesis, Spectral Analysis, DFT and Antimicrobial of Some Novel Benzimidazole Derivatives." International Journal of Trend in Scientific Research and Development 2, no. 4 (2018): 2256–58. https://doi.org/10.31142/ijtsrd14595.

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Two novel 2 substituted benzimidazole derivatives were synthesized from 2 chloromethyl 1H benzimidazole and 2 2 chlorophenyl 1H benzo d imidazole with 1H 1,2,4 triazol 3 amine. Their structures were characterized by Infrared spectroscopy, Nuclear magnetic resonance, 1H, 13C , Elemental analysis. Density functional theory DFT studies were performed using the B3LYP 6 31G d, p basis set to expand imminent into their structural properties. All the synthesized compounds were screened for antimicrobial activity against a panel of selected bacterial and fungal strains using ciprofloxacin and fluconazole as standards. C. M. Mahalakshmi "Synthesis, Spectral Analysis, DFT and Antimicrobial of Some Novel Benzimidazole Derivatives" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-2 | Issue-4 , June 2018, URL: https://www.ijtsrd.com/papers/ijtsrd14595.pdf

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3

Mahmood, Khalid, Zareen Akhter, Fouzia Perveen, et al. "Synthesis, DNA binding and biological evaluation of benzimidazole Schiff base ligands and their metal(ii) complexes." RSC Advances 13, no. 18 (2023): 11982–99. http://dx.doi.org/10.1039/d3ra00982c.

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Two novel benzimidazole ligands (E)-2-((4-(1H-benzo[d]imidazole-2-yl)phenylimino)methyl)-6-bromo-4-chlorophenol and (E)-1-((4-(1H-benzo[d]imidazole-2-yl)phenylimino)methyl) naphthalene-2-ol and their Cu(ii), Ni(ii), Pd(ii) and Zn(ii) complexes were designed and synthesized.

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4

B, Srinivas, and Prabhakara Rao Koya. "Design an efficient method for the synthesis of 2-(1,3-diphenyl-1H-pyrazol-4-yl)-1H-benzo[d]imidazole." Mapana Journal of Sciences 19, no. 2 (2020): 21–31. http://dx.doi.org/10.12723/mjs.53.3.

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A simple, highly efficient and environmentally friendly method has been developed for the synthesis of 2-(1,3-diphenyl-1H-pyrazol-4-yl)-1H-benzo[d]imidazole by using Gadolinium(III) trifluoromethanesulfonate catalyst and ethanol reflux reaction conditions By using this method. 12 new 2-(1,3-diphenyl-1H-pyrazol-4-yl)-1H-benzo[d]imidazole derivatives were synthesized under optimized reactions conditions. All these new products structures are confirmed by spectral analysis. By this method, we achieved imidazole derivatives with more operational simplicity, short reaction time and good yields (up to 85%).

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5

Koparde, Akshada A., Rutuja S. Patil, Shraddha D. Patil, Anup A. Patil, and Namdeo R. Jadhav. "Exploring the Binding Affinity and Molecular Interactions: A Comprehensive Study on the Molecular Docking of Benzimidazole Derivatives." INTERNATIONAL JOURNAL OF PHARMACEUTICAL QUALITY ASSURANCE 15, no. 01 (2024): 237–41. http://dx.doi.org/10.25258/ijpqa.15.1.37.

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The aim of this research work was to study the comparative binding affinities of benzimidazole derivatives (2-methyl-1H-benzo[d]imidazole and 2-phenyl benzimidazole) against COX, LOX, and estrogen receptor. Benzimidazole stands as a vital heterocyclic aromatic organic molecule, playing a pivotal role in medicinal chemistry due to its essential pharmacophore and structural significance. The three-dimensional structures of COX, LOX, and the estrogen receptor were sourced from the PDB database. Concurrently, the structures of the benzimidazole derivatives, namely 2-methyl-1H-benzo[d]imidazole and 2-phenyl benzimidazole, were obtained from the PubChem database. Docking studies were conducted using the PyRx software. A total of nine modes for each receptor were generated, and 2E77 was selected as the best dock. The docking result shows that the interaction of 2-methyl-1H-benzo[d]imidazole with E77 has the highest binding energy. A total of nine modes for each receptor were generated, and 1CX2 was selected as the best dock. The docking result shows that the interaction of 2-phenyl benzimidazole with 1CX2 has the highest binding energy. The in-silico studies show that 2-phenyl benzimidazole has more binding energy with receptors as compared to 2-methyl-1H-benzo[d]imidazole.

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6

Layla Amer Ibrahim and Radhiyah Abdul Baqi Aldujaili. "Synthesis , Characterization and study the Antimicrobial Activity For Benzo pyran -2-imine and Tetrazole Ring Derivatives." Journal of Kufa for Chemical Sciences 3, no. 3 (2024): 178–200. https://doi.org/10.36329/jkcm/2024/v3.i3.15835.

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The derivatives of [3-(1H-benzo[d]imidazol-2-yl)-2H-chromen-2-imine]L8 and [2-((1H-tetrazol-5-yl)methyl)-1H-benzo[d]imidazole] L7,L9 have been obtained using -(1H-benzo[d]imidazol-2-yl)acetonitrile as starting material .The latter compound was utilized as a key intermediate for the synthesis of new heterocyclic compounds L8,7,9 with good yields. Newly synthesized compounds have been screened for their antimicrobial activity and characterized by analytical and spectral data.

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7

Liu, Shenggui, Rongkai Pan, Wenyi Su, Guobi Li, and Chunlin Ni. "Synthesis of a Ruthenium Complex Based on 2,6-Bis[1-(Pyridin-2-yl)-1H-Benzo[d]Imidazol-2-yl]Pyridine and Catalytic Oxidation of (1H-Benzo[d]-Imidazol-2-yl)Methanol to 1H-Benzo[d]Imidazole-2-Carbaldehyde with H2O2." Journal of Chemical Research 41, no. 2 (2017): 88–92. http://dx.doi.org/10.3184/174751917x14858862342106.

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2,6-Bis[1-(pyridin-2-yl)-1H-benzo[d]-imidazol-2-yl]pyridine (bpbp), which has been synthesised by intramolecular thermocyclisation of N2,N6-bis[2-(pyridin-2-ylamino)phenyl]pyridine-2,6-dicarboxamide, reacts with sodium pyridine-2,6-dicarboxylate (pydic) and RuCl3 to give [Ru(bpbp)(pydic)] which can catalyse the oxidation of (1H-benzo[d]imidazol-2-yl)methanol to 1H-benzo[d]imidazole-2-carbaldehyde by H2O2. The optimal reaction conditions were: molar ratios of catalyst to substrate to H2O2 set at 1: 1000: 3000; reaction temperature 50 °C; reaction time 5 h. The yield of (1H-benzo[d]imidazol-2-yl) methanol was 70%.

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8

Jawaharmal, Smita Narwal, Gurvirender Singh, and Dev Rishika Saini. "Synthesis of Novel Imidazoles as Potent Antimicrobial Agents." Indo Global Journal of Pharmaceutical Sciences 02, no. 03 (2012): 305–12. http://dx.doi.org/10.35652/igjps.2012.36.

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Imidazole is a heterocyclic compound with five membered unsaturated ring structure composed of 3 carbons and 2 nitrogen atoms at non–adjacent positions. Imidazole drugs have broad applications in many areas of clinical medicine. These are currently used as tools in pharmacological studies. The important therapeutic properties of imidazole related drugs have encouraged the medicinal chemists to synthesize and test a large number of novel molecules. In this investigation, it was of interest to synthesize 1-(2-bromophenyl)-2-phenyl-1H-phenanthro[9,10-d]imidazole, by reaction of substituted imidazole with bromine in the presence of acetic acid. Various derivatives i.e. 1-(2-bromophenyl)-2-phenyl-1H-phenanthro[9,10-d]imidazole, 1-(2-bromophenyl)-2-(2- nitrophenyl)-1H-phenanthro [9,10-d]imidazole, 1-(2-bromophenyl)-2-(4-chlorophenyl)-1H-phenanthro [9,10-d]imidazole, 1-(2- bromophenyl)-2-(4-styryl-phenyl)-1H-phenanthro [9,10-d]imidazole and 1-(2-bromophenyl)-2-(4-styryl-phenyl)-1H-phenanthro [9,10-d]imidazole were formed with respective yield of 74, 64, 73, 79 and 72%. The structures of the compounds have been established on the basis of spectral analytical data. All the derivatives have been screened for their antimicrobial activities at the 100µg/ml and 200µg/ml against Candida albicans. © 2011 IGJPS. All rights reserved

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9

Mendogralo, Elena Y., Larisa Y. Nesterova, Ekaterina R. Nasibullina, et al. "Synthesis, Antimicrobial and Antibiofilm Activities, and Molecular Docking Investigations of 2-(1H-Indol-3-yl)-1H-benzo[d]imidazole Derivatives." Molecules 28, no. 20 (2023): 7095. http://dx.doi.org/10.3390/molecules28207095.

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The treatment of many bacterial and fungal infections remains a problem due to increasing antibiotic resistance and biofilm formation by pathogens. In the present article, a methodology for the chemoselective synthesis of 2-(1H-indol-3-yl)-1H-benzo[d]imidazole derivatives is presented. We report on the antimicrobial activity of synthesized 2-(1H-indol-3-yl)-1H-benzo[d]imidazoles with significant activity against Staphylococcus aureus ATCC 25923, Staphylococcus aureus ATCC 43300 (MRSA), Mycobacterium smegmatis (mc(2)155/ATCC 700084), and Candida albicans ATCC 10231. High activity against staphylococci was shown by indolylbenzo[d]imidazoles 3ao and 3aq (minimum inhibitory concentration (MIC) < 1 µg/mL) and 3aa and 3ad (MIC 3.9–7.8 µg/mL). A low MIC was demonstrated by 2-(1H-indol-3-yl)-1-methyl-1H-benzo[d]imidazole (3ag) against M. smegmatis and against C. albicans (3.9 µg/mL and 3.9 µg/mL, respectively). 2-(5-Bromo-1H-indol-3-yl)-6,7-dimethyl-1H-benzo[d]imidazole (3aq) showed a low MIC of 3.9 µg/mL against C. albicans. Compounds 3aa, 3ad, 3ao, and 3aq exhibited excellent antibiofilm activity, inhibiting biofilm formation and killing cells in mature biofilms. Molecular docking analysis identified three potential interaction models for the investigated compounds, implicating (p)ppGpp synthetases/hydrolases, FtsZ proteins, or pyruvate kinases in their antibacterial action mechanism.

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Akhtar, Mansoor, Ali Muhammad Arif, Shifa Ullah Khan, Guo-Gang Shan, Hong-liang Xu, and Zhong-Min Su. "Tuning the NLO response of bis-cyclometalated iridium(iii) complexes by modifying ligands: experimental and structural DFT analysis." New Journal of Chemistry 45, no. 12 (2021): 5491–96. http://dx.doi.org/10.1039/d1nj00114k.

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DFT calculations have been carried out to investigate two synthesized iridium(iii) complexes with substituted Phbd (1-phenyl-2-(pyridin-2-yl)-1H-benzo[d]imidazole) and Crbd (9-(4-(2-(pyridin-2-yl)-1H-benzo[d]imidazol-1-yl)phenyl)-9H-carbazole) as ancillary ligands.

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11

Ding, Ming-Wu, Yang-Gen Hu, and Ming-Guo Liu. "2-(1-Naphthylmethyl)-1H-benzo[d]imidazole." Acta Crystallographica Section E Structure Reports Online 63, no. 7 (2007): o3184. http://dx.doi.org/10.1107/s1600536807028449.

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12

Ciber, Luka, Franc Požgan, Jurij Svete, Bogdan Štefane, and Uroš Grošelj. "1-{(1S,2S,4R)-7,7-Dimethyl-1-[(pyrrolidin-1-yl)methyl]bicyclo [2.2.1]heptan-2-yl}-1H-benzo[d]imidazole." Molbank 2023, no. 1 (2023): M1538. http://dx.doi.org/10.3390/m1538.

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A three-step synthesis of 1-{(1S,2S,4R)-7,7-dimethyl-1-[(pyrrolidin-1-yl)methyl]bicyclo[2.2.1]heptan-2-yl}-1H-benzo[d]imidazole, prepared from camphor derived diamine, is disclosed. The absolute configuration at the chiral center bearing benzo[d]imidazole moiety was confirmed by NOESY. The structure of a newly synthesized compound was confirmed by 1H- and 13C-NMR, 2D NMR, IR spectroscopy, and high resolution mass-spectrometry.

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13

Nath, Anisetti Ravinder, and Malladi Srinivas Reddy. "Design, Synthesis, Antibacterial and Antifungal Activity of Novel 2-[(E)-2-aryl-1-ethenyl]-3-(2-sulfanyl-1H-benzo[d]imidazole-5-yl)-3,4- dihydro-4-quinolinones." E-Journal of Chemistry 9, no. 3 (2012): 1481–89. http://dx.doi.org/10.1155/2012/795698.

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The novel 2-[(E)-2-aryl-1-ethenyl]-3-(2-sulfanyl-1H-benzo[d]imidazole-5-yl)-3,4- dihydro-4-quinolinones (4a-j) analogs were synthesized by Knoevenagel condensation of a solution of 2-methyl-3-(2-sulfanyl-1H-benzo[d]imidazole-5-yl)-3,4-dihydro-4-quinazolinone (3) with aromatic aldehyde in presence of catalytic amount of piperidine. Compounds (4a-j) showed significant biological activity against all the standard strains. All the synthesized compounds were characterized on the basis of their IR,1H NMR, MASS spectroscopic data and elemental analyses. All the compounds have been tested for antimicrobial and antifungal activity by the cup-plate method.

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14

Grieco, Gabriele, Olivier Blacque, and Heinz Berke. "A facile synthetic route to benzimidazolium salts bearing bulky aromatic N-substituents." Beilstein Journal of Organic Chemistry 11 (September 17, 2015): 1656–66. http://dx.doi.org/10.3762/bjoc.11.182.

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An atom-economic synthetic route to benzimidazolium salts is presented. The annulated polycyclic systems: 1,3-bis(2,4,6-trimethylphenyl)-1H-benzo[d]imidazol-3-ium chloride (1-Cl), 1,3-bis(2,6-diisopropylphenyl)-1H-benzo[d]imidazol-3-ium chloride (2-Cl), 1,3-diphenyl-1H-benzo[d]imidazol-3-ium chloride (3-Cl), and 1,3-di(pyridin-2-yl)-1H-benzo[d]imidazol-3-ium chloride (4-Cl) were prepared in a two-step synthesis avoiding chromatographic work-up. In the key step triethyl orthoformate is reacted with the correspondingN1,N2-diarylbenzene-1,2-diamines and then further transformed in situ, by alkoxy abstraction using trimethylsilyl chloride (TMSCl), and concomitant imidazole ring closure.

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15

Bhaskar, J. Udaya, G. Srinivasa Rao, Pranab Chatterjee, D. K. Sahoo, S. Srinivasa Rao, and B. Pulla Rao. "Synthesis, Characterization and Antibacterial Screening of Some Novel Compounds containing Multi N-Fused Heterocycles." Asian Journal of Chemistry 36, no. 9 (2024): 2185–90. http://dx.doi.org/10.14233/ajchem.2024.32265.

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An attempt has been made to synthesize novel multi N-fused heterocyclic compounds containing four divergent heterocyclic compounds such as imidazole, pyrimidine, morpholine and indole. A series of N-(4-(1H-benzo[d]imidazol-2-yl)-6-phenylpyrimidin-2-yl)-2-(4-((E)-3-(2-morpholino-9H-pyrido[2,3-b]indol-3-yl)acryloyl)phenylamino)acetamide (6a-c) was accomplished in good yields with 1-(1H-benzo-[d]imidazol-2-yl)ethanone (1) as starting compound and through the formation of (E)-1-(1H-benzo[d]imidazol-2-yl)-3-phenylprop-2-ne-1-ones (2a-c), 4-(1H-benzo[d]imidazol-2-yl)-6-phenylpyrimidin-2-amines (3a-c) and N-(4-(1H-benzo[d]imidazol-2-yl)-6-phenylpyrimidin-2-yl)-2-chloroacetamides (4a-c) as intermediates on extension of the reaction. The structural elucidation of all the synthesized compounds were characterized by IR, 1H NMR, mass spectral data and elemental analysis. Further, the title compounds were also used to evaluate their antibacterial activity.

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Hanson, Samuel S., and Jeffrey J. Warren. "Syntheses, characterization, and electrochemical behavior of alkylated 2-(2′-quinolylbenzimidazole) complexes of rhenium (I)." Canadian Journal of Chemistry 96, no. 2 (2018): 119–23. http://dx.doi.org/10.1139/cjc-2017-0320.

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A series of ClRe(CO)3-containing complexes with 1-methyl-1H-benzo[d]imidazol-2-yl)quinoline (Me-QuBIm), 1-benzyl-1H-benzo[d]imidazol-2-yl)quinoline (Bn-QuBIm), and 2-(1-(4-methoxybenzyl)-1H-benzo[d]imidazol-2-yl)quinoline (OMeBn-QuBIm) ligands were prepared and characterized. Each complex was characterized using 1H and 13C NMR, infrared, UV–vis, and fluorescence spectroscopies, and cyclic voltammetry. The physical properties of each complex are similar to the parent ClRe(CO)3(2-(1H-benzo[d]imidazol-2-yl)quinoline) complex. However, the electrochemical behavior is distinct from the parent, showing reversible voltammograms and poor CO2 reduction activity. Addition of K+ or Mg2+ as Lewis acids modestly increases catalytic currents, but at large overpotentials. The work presented here is consistent with a mechanism that involves rhenium reduction and deprotonation of imidazole and benzimidazole prior to CO2 reduction electrocatalysis.

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Hamza Sherif, Salah, and Y. L.N. Murthy. "Design and synthesis of indole-benzimidazole hybrid molecules and evaluation of their in-vitro cytotoxic activities." Bulletin of the Chemical Society of Ethiopia 37, no. 5 (2023): 1209–20. http://dx.doi.org/10.4314/bcse.v37i5.13.

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ABSTRACT. Cancer is one of the most deadly diseases worldwide, challenging the world for effective treatment of the diseases, to tackle this problem a vast amount of therapeutic candidates are being investigated. Indole-benzimidazole structures have recently gained considerable attention, because compounds containing these structure exhibit a very good anticancer property. Two series of novel indole-benzimidazole hybrids molecules viz., 2-(5-substituted-1H-indol-3-yl)-5-substituted-1H-benzo[d]imidazole 5(a-f) and 2-(5-substituted-1-(3-methylbut-2-enyl)-1H-indol-3-yl)-5-substituted-1H-benzo[d]imidazole 6(a-f) were synthesized and characterized by spectroscopic techniques. The twelve target molecules have been investigated for their in-vitro cytotoxic activity against human ovarian carcinoma cells (SKOV-3), human prostate cancer cells (PC-3), human cervical cancer cells (HeLa) and human acute monocytic leukemia cells (THP-1) using MTT assay. Compound; 2-(5-bromo-1H-indol-3-yl)-5-methyl-1H-benzo[d]imidazole (5e) was interesting with IC50 (μM) values of 23.69 (SKOV-3), 73.05 (PC-3), 64.66 (HeLa) and 39.08 (THP-1), respectively.  KEY WORDS: Indole, Benzimidazole, Hybrid molecules, Anticancer activity  Bull. Chem. Soc. Ethiop. 2023, 37(5), 1209-1220.  DOI: https://dx.doi.org/10.4314/bcse.v37i5.13

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18

Yoon, Yeong Keng, Mohamed Ashraf Ali, Ang Chee Wei, Ching Kheng Quah, and Hoong-Kun Fun. "Ethyl 1-[3-(1H-imidazol-1-yl)propyl]-2-(4-chlorophenyl)-1H-benzo[d]imidazole-5-carboxylate dihydrate." Acta Crystallographica Section E Structure Reports Online 67, no. 9 (2011): o2405. http://dx.doi.org/10.1107/s1600536811033654.

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Parmar, Tejasvi H., Chetan B. Sangani, and Mahesh Kulkarni. "Synthesis of novel drug-like small molecules library based on 1." Australian Journal of Chemistry 75, no. 4 (2022): 276–84. http://dx.doi.org/10.1071/ch21238.

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A series of novel ‘drug-like’ small molecules based on 1H-benzo[d]imidazole derivatives bearing furan-2-yl, 4-piperidine and 5-aryl/aminoaryl substitutions were designed and synthesised. The key intermediate tert-butyl-4-(5-bromo-2-(furan-2-yl)-1H-benzo[d]imidazol-1-yl)piperidine-1-carboxylate (5) was synthesised via sequential reaction starting from 4-bromo-1-fluoro-2-nitrobenzene (1). The 5-aryl-substituted molecular library was generated via Suzuki–Miyura coupling of tert-butyl-4-(5-bromo-2-(furan-2-yl)-1H-benzo[d]imidazol-1-yl)piperidine-1-carboxylate (5) with various boronic acids while Buchwald coupling of 5 with various anilines generated the second molecular library of tert-butyl-4-(2-(furan-2-yl)-5-(arylamino)-1H-benzo[d]imidazol-1-yl)piperidine-1-carboxylates. The structures of all the newly synthesised compounds were confirmed by spectral analysis. The optimised procedure gives easy access to two new molecular libraries of 1H-benzo[d]imidazoles with operational simplicity and good yield.

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Lu, Zhongkai, Yan Gao, Hong Chen, Zhao Liu, Lifang Chen, and Licheng Sun. "Efficient molecular ruthenium catalysts containing anionic ligands for water oxidation." Dalton Transactions 45, no. 46 (2016): 18459–64. http://dx.doi.org/10.1039/c6dt02056a.

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Two new mononuclear Ru complexes Ru<sup>II</sup>(bipa)(pic)<sub>3</sub> (1; H<sub>2</sub>bipa = 6-(1H-benzo[d]imidazol-2-yl)picolinic acid, pic = 4-picoline) and Ru<sup>II</sup>(pbic)(pic)<sub>3</sub> (2; H<sub>2</sub>pbic = 2-(pyridin-2-yl)-1H-benzo[d]imidazole-7-carboxylic acid, pic = 4-picoline) based on anionic ligands were successfully synthesized, and characterized using NMR spectroscopy, mass spectrometry, and X-ray crystallography.

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Katikireddy, Ramamurthy, Ramu Kakkerla, M. P. S. Murali Krishna, Gandamalla Durgaiah, Y. N. Reddy, and Mavurapu Satyanarayana. "Synthesis and Biological Evaluation of (E)-N’-Benzylidene-7-methyl-2-propyl-1H-benzo[d] imidazole-5-carbohydrazides as Antioxidant, Anti-inflammatory and Analgesic agents." Heterocyclic Communications 25, no. 1 (2019): 27–38. http://dx.doi.org/10.1515/hc-2019-0009.

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Abstract(E)-N’-Benzylidene-7-methyl-2-propyl-1H-benzo [d]imidazole-5-carbohydrazides (5a-r) have been synthesized from 7-methyl-2-propyl-1H-benzo[d]imidazole-5-carbohydrazide (3) by condensing with different aromatic aldehydes (4a-r). Title compounds (5a-r) were evaluated for in vitro antioxidant activity and based on their potential for antioxidant property, selected compounds 5d and 5m-p were screened for in vivo anti-inflammatory and analgesic activity. The results indicate that the compound 5o and 5p are effective against anti-inflammatory and analgesic activity. The biological data was further supported by molecular docking studies, which revealed the binding pattern and the affinity of the molecules in the active site of COX-2.

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Solo, Peter, Dziesekhrietuo Khruomo, Antidong Jamir, et al. "Synthesis, Crystal Structure and DFT Analysis of 2-(2-Chlorophenyl)-1H-benzo[d]imidazole as Charge Transport and Non-Linear Optical Material." Asian Journal of Chemistry 37, no. 5 (2025): 1090–100. https://doi.org/10.14233/ajchem.2025.33563.

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A benzimidazole crystal, specifically 2-(2-chlorophenyl)-1H-benzo[d]imidazole, exhibiting distinctive unit cell parameters has been synthesized and its crystal structure (CCDC no: 2390665) has been confirmed through single-crystal X-ray diffraction. The stability of the structure is primarily attributed to N-H---N interactions, while relatively weaker Cl---H interactions also play a role in the crystal formation. Hirshfeld surface analysis has been employed to investigate the non-covalent interactions and to gain insights into the crystal packing. Additionally, DFT quantum chemical calculations have been conducted to examine reactivity indices, electronic transition band gaps and the density of states of the synthesized compound. It is postulated that this compound not only contributes to the existing crystallographic data but may also serve as a material for ambipolar charge transfer applications, as well as in optical and nonlinear optical studies.

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Odabaşoğlu, Mustafa, Orhan Büyükgüngör, B. Narayana, A. M. Vijesh, and H. S. Yathirajan. "5-Methoxy-1H-benzo[d]imidazole-2(3H)-thione." Acta Crystallographica Section E Structure Reports Online 63, no. 7 (2007): o3199—o3200. http://dx.doi.org/10.1107/s1600536807027730.

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Tardío, Carlos, Javier Álvarez Conde, Ana María Rodríguez, et al. "Donor–Acceptor–Donor 1H-Benzo[d]imidazole Derivatives as Optical Waveguides." Molecules 28, no. 12 (2023): 4631. http://dx.doi.org/10.3390/molecules28124631.

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A new series of donor–acceptor–donor (D–A–D) structures derived from arylethynyl 1H-benzo[d]imidazole was synthesized and processed into single crystals with the goal of testing such crystals’ ability to act as optical waveguides. Some crystals displayed luminescence in the 550–600 nm range and optical waveguiding behavior with optical loss coefficients around 10−2 dB/μm, which indicated a notable light transport. The crystalline structure, confirmed by X-ray diffraction, contains internal channels that are important for light propagation, as we previously reported. The combination of a 1D assembly, a single crystal structure, and notable light emission properties with low losses from self-absorption made 1H-benzo[d]imidazole derivatives appealing compounds for optical waveguide applications.

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Yadav, Smriti, Bharath Kumar Inturi, Shrinidhi B.R, Pooja H.J, Neenu Ganesh, and Gurubasavaraj V. Pujar. "Design, Synthesis and Antitubercular Evaluation of New Benzimidazole Scaffolds." Anti-Infective Agents 18, no. 4 (2021): 375–83. http://dx.doi.org/10.2174/2211352518666200108091454.

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Background: To overcome one of the resistance mechanisms of Isoniazid (INH), there is a need for an antitubercular agent that can inhibit InhA enzyme by circumventing the formation of INH-NAD+ adduct. Objective: The objective of the study is the development of novel antitubercular agents that target Mycobacterium tuberculosis InhA (Enoyl Acyl Carrier Protein Reductase). Methods: A small-molecule chemical library was used for the identification of the novel InhA inhibitors using primary screening and molecular docking studies followed by the scaffold hopping approach. The designed molecules, 2-(2-(hydroxymethyl)-1H- benzo[d] imidazole-1-yl)- N- substituted acetamides were synthesized by reacting (1H- benzo[d]imidazole -2-yl)methanol with appropriate 2-chloro-N-substituted acetamides / dialkylamino carbonyl chlorides respectively in good yields (42-65%). The antitubercular activity of synthesized compounds was determined by Microplate Alamar Blue Assay (MABA) against Mycobacterium tuberculosis H37Rv strain. The selected compounds were screened for cytotoxicity on normal cell lines. Results: The antitubercular activity data revealed that the 4-chlorophenyl substituted derivative (3b) showed good MIC value at 6.25 μg/mL and, dimethylacetamide substituted derivative (3i) showed MIC at 25 μg/mL among the tested compounds. The substitution of dimethylacetamide (3i) group on the 1st position of benzimidazole has good antitubercular activity (25μg/mL) in comparison to the diethyl acetamide group (3j, 100μg/mL). Conclusion: The antitubercular activity data indicated that the tested compounds exhibited well to moderate inhibition of the H37Rv strains. The compounds (3b) with electronegative substitution on the phenyl moiety exhibited better antitubercular activity than that of the other substitutions. The active compounds have displayed a good safety profile on normal cell lines.

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Yılmaz, Tuğçe, Elif Ergin, Hatice Oruç Demirbağ, and Semra Utku. "IN VITRO CYTOTOXIC ACTIVITIES OF PLATINUM(II) COMPLEXES CONTAINING 1H-BENZO[d]IMIDAZOLE AND 1H-1,3-DIAZOLE DERIVATIVES." Ankara Universitesi Eczacilik Fakultesi Dergisi 48, no. 3 (2024): 3. http://dx.doi.org/10.33483/jfpau.1461131.

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Objective: This study aimed to synthesize and evaluate the cytotoxic activities of four platinum(II) complexes with 2-substituted or nonsubstituted 1H-benzo[d]imidazole and 1H-1,3-diazole derivatives as carrier ligands (L1-L4), which may have potent cytotoxic activity and low side effects. Material and Method: K1-K4 complexes were synthesized by heating and mixing K2PtCl4 and the appropriate L1-L4. The chemical structures of K1-K4 were elucidated by Infrared and 1H Nuclear Magnetic Resonance spectroscopic methods. In vitro, cytotoxic effects of K1-K4 complexes against prostate (DU-145), endometrial adenocarcinoma (Ishikawa), and breast cancer (MCF-7) cell lines were tested by the MTT method. Result and Discussion: According to the IC50 values of the tested cell lines, K1 and K2 derivatives bearing unsubstituted 1H-benzo[d]imidazole (L1) and 1H-1,3-diazole (L2) were found to be the most effective compounds among these synthesized complexes.

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Keivanloo, Ali, Atena Soozani, Mohammad Bakherad, and Amir Hossein Amin. "A one-pot synthetic approach for the construction of a thiazolo[3,2-a]benzimidazole-linked quinazoline scaffoldviapalladium-catalyzed reactions." Organic Chemistry Frontiers 5, no. 7 (2018): 1135–42. http://dx.doi.org/10.1039/c7qo00751e.

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4-(2-Substituted-[1,3]thiazolo[3,2-a]benzimidazol-3-yl)quinazolin-2-amines were prepared by the reaction of 2,4-dichloroquinazoline, terminal alkynes, secondary amines, and 1H-benzo[d]imidazole-2(3H)-thione in the presence of palladium catalyst.

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Shruthi, N., Boja Poojary, Vasantha Kumar, et al. "Novel benzimidazole–oxadiazole hybrid molecules as promising antimicrobial agents." RSC Advances 6, no. 10 (2016): 8303–16. http://dx.doi.org/10.1039/c5ra23282a.

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In the present study, we describe the design and expeditious synthesis of novel 2-aryl-5-(3-aryl-[1,2,4]-oxadiazol-5-yl)-1-methyl-1H-benzo[d]imidazole hybrid molecules as promising antimicrobial agents.

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Wang, Fang, Xue Wang, Min-Xia Zhang, Yong-Hua Yang, and Hai-Liang Zhu. "Synthesis, biological evaluation and molecular modeling of 1H-benzo[d]imidazole derivatives as novel anti-tubulin polymerization agents." RSC Advances 5, no. 91 (2015): 74425–37. http://dx.doi.org/10.1039/c5ra13746b.

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A series of novel compounds (8a–21b) were designed and synthesized based on 2-phenyl-1H-benzo[d]imidazole. Compound 18b showed the most potent in vitro growth inhibitory activity and significant tubulin polymerization inhibitory activity.

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30

Zhai, Dapeng, Jing Yang, Zhengyu Guo, Qiusheng Wang, and Jie Ouyang. "A fluorescent probe for the detection of Mg(ii) and Cu(ii) and its application for imaging in living cells." RSC Adv. 4, no. 87 (2014): 46800–46805. http://dx.doi.org/10.1039/c4ra06635a.

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A novel fluorescent probe 7-[4′-hydroxy-3′-(5′′-methyl-1H-benzo[d]imidazole-2-yl)styryl]nalidixic acid (HBIN) was synthesized that contains two independent fluorophores and acts as a very sensitive and selective probe for Mg<sup>2+</sup> and Cu<sup>2+</sup> ions.

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Główka, Marek L., Sylwia Kałużyńska, Malwina Krause, et al. "The structures of benzimidazole derivatives and their potential as tuberculostatics." Acta Crystallographica Section C Structural Chemistry 74, no. 12 (2018): 1684–91. http://dx.doi.org/10.1107/s2053229618014675.

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Tuberculosis still remains a very important problem, especially its multidrug resistant varieties (MDR-TB). Among the potential tuberculostatics, there are two benzimidazole derivatives, namely 5,6-dimethyl-2-phenylethylbenzo[d]imidazole (1) and (E)-5,6-dimethyl-2-styryl-1H-benzo[d]imidazole (2) which showed significant tuberculostatic activities, better than those of Pyrazinamide and Isoniazyd. Also, the cytotoxicity of 1 appeared promising. The compounds were studied (with the use of X-ray diffraction) in the form of the hemihydrate of 1, C17H18N2·0.5H2O (1a), the methanol hemisolvate of 2, C17H16N2·0.5CH3OH (2a), and the acid oxalate salt of 2, namely (E)-5,6-dimethyl-2-styryl-1H-benzo[d]imidazolium hydrogen oxalate, C17H17N2 +·C2HO4 − (2b). All three structures reveal a similar extended conformation, despite the flexible linker between the two aromatic systems and the different types of strong intermolecular hydrogen bonds. The molecules of 2a are practically planar due to the double bond in the linker, which enables conjugation along the whole molecule, while the molecules of 1a exhibit the possibility of parallel orientations of their aromatic systems, despite the aliphatic (ethyl) linker.

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Bhaskar, Prakash, Vasantha Kumar, Suresha Kumara Tholappanavara Hanumanthappa, and Sowmya Haliwana Banakara Vijaykumar. "2-(3,4-Dimethoxyphenyl)-N-(4-methoxyphenyl)-1-propyl-1H-benzo[d]imidazole-5-carboxamide." Molbank 2019, no. 3 (2019): M1079. http://dx.doi.org/10.3390/m1079.

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2-(3,4-Dimethoxyphenyl)-N-(4-methoxyphenyl)-1-propyl-1H-benzo[d]imidazole-5-carboxamide was synthesized by the ‘one-pot’ reductive cyclization of N-(4-methoxyphenyl)-3-nitro-4-(propylamino)benzamide with 3,4-dimethoxybenzaldehyde, using sodium dithionite as a reductive cyclizing agent using DMSO as a solvent. The structure of newly synthesized compound was elucidated based on IR, 1H-NMR, 13C-NMR, and LC-MS data.

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33

Rufaida, Farheen *. Y. Rajesh Babu 1. "SYNTHESIS AND CHEMICAL CHARACTERIZATION OF BENZIMIDAZOLE FUSED BENZOPYRAN DERIVATIVES AND EVALUATION OF THEIR ANTI-BACTERIAL POTENCY." Journal of Pharma Research 8, no. 3 (2019): 88–93. https://doi.org/10.5281/zenodo.2620330.

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<strong><em>ABSTRACT</em></strong> <strong><em>B</em></strong><em>enz-imidazole fused benzopyran derivatives were prepared by the reaction of 2-(1H-Benzo[d]Imidazol-2-yl)-1phenyl-1H-Benzo[f]chromeno-3-amine with different substituted benzaldehydes. The resulting derivatives were subjected to physical and chemical characterization. The anti-bacterial potency of the synthesized compounds was tested against a set of Gram positive and negative bacteria. The compound 9-(2-methoxyphenyl)-16-phenyl-16H-benzo[4,5]imidazo[1,2-c]benzo[5,6]chromeno[3,2-e]pyrimidine exhibited most potent activity. Detailed toxicological studies and molecular modelling would be beneficial in developing new drugs.</em> <strong><em>KEYWORDS: </em></strong><em>Benzimidazole, Benzopyran, Coumarin, Anti-Bacterial, Disc-Diffusion.</em>

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34

Alshahrani, Saeed, Saied M. Soliman, Abdullah Saleh Alamary, et al. "Synthesis of Enaminones-Based Benzo[d]imidazole Scaffold: Characterization and Molecular Insight Structure." Crystals 10, no. 10 (2020): 955. http://dx.doi.org/10.3390/cryst10100955.

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(E)-1-(1H-Benzo[d]imidazol-2-yl)-3-(dimethylamino)prop-2-en-1-one 2 was synthesized by one-pot synthesis protocol of 2-acetyl benzo[d]imidazole with dimethylformamide dimethylacetal (DMF-DMA) in xylene at 140 °C for 8 h. Reaction of enaminone derivative 1 with acetylacetone in the presence of AcOH/NH4OAc under reflux afforded the cyclized pyridino-benzo[d]imidazole derivative 3. The latter compound was converted into the corresponding β-enaminone 4 with DMF-DMA. The single crystal X-ray diffraction technique eventually confirmed the assigned chemical structure of the N-alkyl-β-enaminone 2 and pyridino-benzo[d]imidazole derivative 3. N-alkyl-β-enaminone 2 crystallized in the monoclinic space group P21/n with unit cell parameters of a = 9.8953(3) Å, b = 5.7545(2) Å, c = 21.7891(7) Å, and β =100.627(2)°, and with one molecule per asymmetric unit. On the other hand, compound 3 crystallized in the orthorhombic crystal system and space group P212121 with unit cell parameters of a = 6.82950(10) Å, b = 8.00540(10) Å, c = 22.4779(2) Å, and also with one molecule per asymmetric unit. Based on Hirshfeld analysis, the H...H (51.3%), O...H (10.0%), N...H (10.3%), and C...H (27.6%) contacts in 2 and the H...H (46.8%), O...H (9.9%), N...H (13.0%), and C...H (21.6%) in addition to the C…C (6.7%) interactions in 3 are the most important towards crystal stability via molecular packing. The main difference is the presence of π–π interaction among the molecular units of 3 but not in 2. The calculated 1H and 13C NMR chemical shifts showed good agreements with experimental data. Electronic properties and reactivity parameters of both compounds are also calculated and compared.

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35

Özdemi̇r, Namik, Bi̇lge Eren, Muharrem Di̇nçer, and Yunus Bekdemi̇r. "Quantum-chemical, IR, NMR, and X-ray diffraction studies on 2-(4-chlorophenyl)-1-methyl- 1H -benzo[d ]imidazole." International Journal of Quantum Chemistry 111, no. 12 (2010): 3112–24. http://dx.doi.org/10.1002/qua.22697.

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36

Shi, Xing-Xing, Qiu-Jie Chen, Xue-Li Chen, Yuexing Zhang, Mohamedally Kurmoo та Ming-Hua Zeng. "Monitoring fragmentation and oligomerization of a di-μ-methoxo bridged copper(ii) complex: structure, mass spectrometry, magnetism and DFT studies". Dalton Transactions 48, № 34 (2019): 13094–100. http://dx.doi.org/10.1039/c9dt02890k.

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The flat binuclear [Cu<sub>2</sub>(L)<sub>2</sub>Cl<sub>2</sub>] (HL = (1-methyl-1H-benzo[d]imidazole-2-yl)methanol) was studied by mass spectrometry and DFT calculations. Particularly, it shows strong antiferromagnetism with g = 2.20, J = −465 cm<sup>−1</sup> and zj = −0.83 cm<sup>−1</sup>.

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37

Raghuramarao, Irigineni, L. Krishnakanth Reddy, and B. Kishore Babu. "Proposal, Synthesis and Antimicrobial activity of 1-((1-phenyl-1H-1,2,3-triazol-5-yl)methyl)-2-(4-phenyl-2H-chromen-3-yl)-1H-benzo[d]imidazole." Research Journal of Chemistry and Environment 28, no. 5 (2024): 52–59. http://dx.doi.org/10.25303/285rjce052059.

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A new series of 1-((1-phenyl-1H-1,2,3-triazol-5-yl) methyl)-2-(4-phenyl-2H-chromen-3-yl)-1H-benzo [d] imidazole (12a-n) and a library of novel imidazole-1,2,3-triazole hybrids were designed and synthesized based on the fusion pharmacophore approach. Therefore, copper (I) catalyzed click reaction of propargylated imidazole with numerous organo arylazides yielded imidazole-1,2,3-triazole hybrids 12a–n. The products were purified over column chromatography and structures of these compounds are recognized by IR, 1H-NMR, 13C-NMR and mass spectral data. All the final compounds were screened for their anti-microbial activity and the effects were matched with ciprofloxacin. Compound (12d, l, i) was the most effective compound of this series and with activities improved than ciprofloxacin under the experienced situations. Chroman-4-one scaffold is a stable structure in heterocyclic chemistry and drug conclusion.

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38

Dzedulionytė, Karolina, Melita Veikšaitė, Vít Morávek, et al. "Convenient Synthesis of N-Heterocycle-Fused Tetrahydro-1,4-Diazepinones." Molecules 27, no. 24 (2022): 8666. http://dx.doi.org/10.3390/molecules27248666.

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A general approach towards the synthesis of tetrahydro-4H-pyrazolo[1,5-a][1,4]diazepin-4-one, tetrahydro[1,4]diazepino[1,2-a]indol-1-one and tetrahydro-1H-benzo[4,5]imidazo[1,2-a][1,4]diazepin-1-one derivatives was introduced. A regioselective strategy was developed for synthesizing ethyl 1-(oxiran-2-ylmethyl)-1H-pyrazole-5-carboxylates from easily accessible 3(5)-aryl- or methyl-1H-pyrazole-5(3)-carboxylates. Obtained intermediates were further treated with amines resulting in oxirane ring-opening and direct cyclisation—yielding target pyrazolo[1,5-a][1,4]diazepin-4-ones. A straightforward two-step synthetic approach was applied to expand the current study and successfully functionalize ethyl 1H-indole- and ethyl 1H-benzo[d]imidazole-2-carboxylates. The structures of fused heterocyclic compounds were confirmed by 1H, 13C, and 15N-NMR spectroscopy and HRMS investigation.

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Siddig, Lamia A., Mohammad A. Khasawneh, Abdelouahid Samadi, Haythem Saadeh, Nael Abutaha, and Mohammad Ahmed Wadaan. "Synthesis of novel thiourea-/urea-benzimidazole derivatives as anticancer agents." Open Chemistry 19, no. 1 (2021): 1062–73. http://dx.doi.org/10.1515/chem-2021-0093.

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Abstract A new series of urea and thiourea derivatives containing benzimidazole group as potential anticancer agents have been designed and synthesized. The structures of the synthesized compounds were characterized and confirmed by spectroscopic techniques such as 1H NMR, 13C NMR, and mass spectrometry. In vitro anticancer assay against two breast cancer (BC) cell lines, MDA-MB-231ER(−)/PR(−) and MCF-7ER(+)/PR(+), revealed that the cytotoxicity of 1-(2-(1H-benzo[d]imidazol-2-ylamino)ethyl)-3-p-tolylthiourea (7b) and 4-(1H-benzo[d]imidazol-2-yl)-N-(3-chlorophenyl)piperazine-1-carboxamide (5d) were higher in MCF-7 with IC50 values of 25.8 and 48.3 µM, respectively, as compared with MDA-MB-231 cells. Furthermore, 7b and 5d were assessed for their apoptotic potential using 4′,6-diamidino-2-phenylindole, acridine orange/ethidium bromide staining, and Caspase-3/7. After incubation with MCF-7, the compounds 7b and 5d induced apoptosis through caspase-3/7 activation. In conclusion, the compounds 7b and 5d are potential candidates for inducing apoptosis in different genotypic BC cell lines.

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40

Sathyanarayana, Reshma, and Boja Poojary. "Ethyl 1-Butyl-2-(2-hydroxy-4-methoxyphenyl)-1H-benzo[d]imidazole-5-carboxylate." Molbank 2021, no. 1 (2021): M1192. http://dx.doi.org/10.3390/m1192.

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Ethyl 4-(butylamino)-3-nitrobenzoate upon “one-pot” nitro-reductive cyclization using sodium dithionite and substituted aldehyde in dimethyl sulphoxide affords ethyl 1-butyl-2-(2-hydroxy-4-methoxyphenyl)-1H-benzo[d]imidazole-5-carboxylate in an 87% yield. The structural characterization was determined by Fourier-transfer infrared spectroscopy (FT-IR), Proton nuclear magnetic resonance (1H-NMR), Carbon-13 nuclear magnetic resonance (13C-NMR), mass spectrometry, Ultraviolet-visible(UV-Vis), photoluminescence (PL), thin-film solid emission spectra, cyclic voltammetry (CV) and thermogravimetric (TGA) analysis. Molecular electrostatic potential (MEP) was studied to determine the reactive sites of the molecule.

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41

He, Y. X. "Solvent Evaporation Method and Crystal Structure of 2-[5-(1H-benzo[d]imidazol-2-yl)pyridin-3-yl]-1H-benzo[d]imidazole." Asian Journal of Chemistry 27, no. 2 (2015): 783–84. http://dx.doi.org/10.14233/ajchem.2015.17426.

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42

Brătulescu, George. "ALKYL-1H-BENZO[D]IMIDAZOLE SYNTHESIS FROM ALKYL BROMIDES AND 1,2-BENZENEDIAMINES BY A MILD DOMINO REACTION." Annals of the University of Craiova, Series Chemistry 27, no. 2 (2021): 5–11. http://dx.doi.org/10.52846/auc.chem.2021.2.01.

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A method was implemented for synthesis of 2-alkyl-1H-benzo[d]imidazole derivatives in dry medium. Starting reagents, 1,2-diaminobenzene derivatives and primary alkyl halides using pyridine N-oxide is converted into benzimidazoles. The protocol does not use catalyst and solvent. Simplicity and easy work-up are the important advantages of the method.

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43

Brătulescu, George. "ALKYL-1H-BENZO[D]IMIDAZOLE SYNTHESIS FROM ALKYL BROMIDES AND 1,2-BENZENEDIAMINES BY A MILD DOMINO REACTION." Annals of the University of Craiova, Series Chemistry 27, no. 2 (2021): 5–11. http://dx.doi.org/10.52846/aucchem.2021.2.01.

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A method was implemented for synthesis of 2-alkyl-1H-benzo[d]imidazole derivatives in dry medium. Starting reagents, 1,2-diaminobenzene derivatives and primary alkyl halides using pyridine N-oxide is converted into benzimidazoles. The protocol does not use catalyst and solvent. Simplicity and easy work-up are the important advantages of the method.

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44

Che, Zhijian, Shaoxiang Wang, Shenggui Liu, et al. "Synthesis, structure, photoluminescence and antitumour activity of zinc complex based on 2-(2-(1H-benzo-[d]imidazol-2-yl)benzyl)-1H-benzo-[d]imidazole." Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 135 (January 2015): 878–82. http://dx.doi.org/10.1016/j.saa.2014.07.098.

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45

Meany, Fiach B., Sarah O’Rourke, and Paul V. Murphy. "1-Tosyl-6-vinyl-4,5,6,7-tetrahydro-1H-benzo [d] imidazole-2-amine." Molbank 2021, no. 3 (2021): M1262. http://dx.doi.org/10.3390/m1262.

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The alkene functionalised 2-aminobenzimidazole ring found in terrazoanthine natural products was synthesized in 3 steps from 1,2-epoxy-4-vinylcyclohexane via epoxide ring opening with toluenesulphonamide yielding 2 regioisomeric, separable amino alcohols. One isomer was oxidized to the corresponding ketone and subsequently condensed with cyanamide to furnish the title compound, which was characterized by 1H-NMR and 13C-NMR spectroscopy.

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Chunduri, Venkata Rao. "Synthesis and Antibacterial Activity of Novel Benzimidazole Linked 1,3,4-Oxadiazole Derivatives." Medicinal Chemistry 9, no. 2 (2019): 6. https://doi.org/10.4172/2161-0444.1000529.

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With an intention to develop potent antimicrobial agents from the source of benzimidazole- 1,3,4-oxadiazole combined heterocyclic derivatives, novel 6-Chloro-2-(2-(5-(substituted phenyl)-1,3,4-oxadiazol-2-yl)ethyl)- 1H-benzo[d]imidazole derivatives were synthesized using condensation reaction of 3-(6-chloro-1H-benzo[d] imidazol-2-yl)propane hydrazide and benzoic acids as key step in presence of POCl3 . All newly synthesized target compounds (4a-4n) were characterized by 1 H NMR, Mass and IR spectral studies and were screened for their antibacterial activity with two bacterial pathogens (Gram positive: Bacillus subtilis, Gram negative: Escherichia coli) which confirmed that compounds 4a, 4b, 4d, 4g, 4h and 4n have potent activity against B. subtilis as compare with gentamicin at concentration 500 µg/mL. We hope that this study may helpful for further optimization in finding of lead antimicrobials from the origin of benzimidazole linked oxadiazole derivatives.

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ZOMORODIAN, K., S. KHABNADIDEH, L. ZAMANI, K. PAKSHIR, and M. TAJADDOD. "EVALUATION OF ANTIFUNGAL AND ANTIBACTERIAL ACTIVITY OF SOME NEW BENZIMIDAZOLE DERIVATIVES." Latin American Applied Research - An international journal 48, no. 2 (2018): 125–29. http://dx.doi.org/10.52292/j.laar.2018.270.

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The extensive use of antifungal drugs and their resistance against fungal infections have led to discover new antimicrobial compounds. We previously described synthesis of some new derivatives of 2-methylbenzimidazole (1a-5a) and 5,6dimethylbenzimidazol (1b-5b). Here we evaluated the antimicrobial activities of these compounds against different species of micro organisms including gram positive and gram negative bacteria as well as fungi. Broth micro-dilution method as recommended by clinical and laboratory standard institute (CLSI) was used for this purpose. The results show compounds 2-Methyl-1-(3-methylbenzyl)-1H-benzo [d]imidazole (5a) and 5,6-Dimethyl-1-(3-methyl benzyl)-1H-benzo[d]imidazole (5b) had the best antifungal activity against the examined fungi and gram positive bacteria. Moreover these two compounds inhibited the growth of azole resistant strains. By comparison the relationship between the structures and activities of the tested compounds revealed that the presence of methyl residue in meta position of benzyl group enhance the antifungal activity. Regarding a broad spectrum antifungal activities of some of the tested compounds, they might be a good candidate for further in vivo studies to evaluate their pharmacological activity and toxicity as a novel antifungal agents.

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Raju, D. Suryanarayana, R. L. C. Sasidhar, and S. Vidyadhara. "Synthesis, Characterization, Screening and Docking Studies of Some Novel 5-Chloro benzimidazole-2-one Derivatives as Potent Antitubercular Agents." Asian Journal of Organic & Medicinal Chemistry 5, no. 2 (2020): 85–90. http://dx.doi.org/10.14233/ajomc.2020.ajomc-p242.

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A series of 5-chloro-1-(piperidin-4-yl)-1H-benzo[d]imidazole-2(3H)-one derivatives have been synthesized and characterized by various spectroscopic techniques including FTIR, mass and 1H NMR. In current study, we have followed standard methods for the synthesis of novel molecules, docking and screening against mycobacterium species. The compounds were docked against 2Q1Y protein by using MCULE software and screened them by MABA. Out of sixteen synthesized molecules, two molecules i.e. DSR-14 and DSR-9 had shown good antitubercular activity.

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Edukondalu, Perugu, Reddymasu Sireesha, Chandra Mohan Bandaru, Mandava Venkata Basaveswara Rao, Pruthu Kala, and Rudraraju Ramesh Raju. "Design, Synthesis and anticancer evaluation of 2-(5-(Benzo[d]thiazol-2-yl)-1H-imidazol-1-yl)-5-aryl-1H-benzo[d]imidazole derivatives." Chemical Data Collections 35 (October 2021): 100753. http://dx.doi.org/10.1016/j.cdc.2021.100753.

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SELVANAYAGAM, S., B. SRIDHAR, K. RAVIKUMAR, S. KATHIRAVAN, and R. RAGHUNATHAN. "Crystal Structure of 1-(Propa-1,2-dienyl)-1H-benzo(d)imidazole-2-carbaldehyde." X-ray Structure Analysis Online 26 (2010): 59–60. http://dx.doi.org/10.2116/xraystruct.26.59.

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