Relevant bibliographies by topics / 2-oxoindoline derivative

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Academic literature on the topic '2-oxoindoline derivative'

Author: Grafiati
Published: 4 June 2025
Last updated: 23 June 2025

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Journal articles on the topic "2-oxoindoline derivative"

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Abu-Hashem, Ameen Ali, and Sami A. Al-Hussain. "Design, Synthesis of New 1,2,4-Triazole/1,3,4-Thiadiazole with Spiroindoline, Imidazo[4,5-b]quinoxaline and Thieno[2,3-d]pyrimidine from Isatin Derivatives as Anticancer Agents." Molecules 27, no. 3 (2022): 835. http://dx.doi.org/10.3390/molecules27030835.

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The current work aims to design and synthesis a new series of isatin derivatives and greatly enhances their cytotoxic activity. The derivatives 3-((bromophenyl) imino)-1-(morpholino (pyridine) methyl) indolin-2-one, 2-((oxoindoline) amino) benzoic acid, 3-(thiazolo-imino) indolinone, ethyl-2-((oxoindolin-3-ylidene)amino)-benzothiophene-3-carboxylate, 1-(oxoindoline)-benzo[4,5] thieno [2,3-d]pyrimidin-4(1H)-one, ethyl-2-(2-oxoindoline) hydrazine-1-carboxylate, N-(mercapto-oxo-pyrimidine)-2-(oxoindoline) hydrazine-1-carboxamide, N-(oxo-thiazolo[3,2-a] pyrimidine)-2-(oxoindolin-ylidene) hydrazine-carboxamide, 3-((amino-phenyl) amino)-3-hydroxy- indolinone, 3-((amino-phenyl) imino)-indolinone, 2-(2-((oxoindoline) amino) phenyl) isoindolinone, 2-(oxoindoline) hydrazine-carbothioamide, 5′-thioxospiro[indoline-3,3′-[1,2,4]triazolidin]-one, 5′-amino-spiro[indoline-3,2′-[1,3,4]thiadiazol]-2-one and 3-((2-thioxo-imidazo[4,5-b]quinoxaline) imino) indolinone were synthesized from the starting material 1-(morpholino (pyridine) methyl) indoline-2,3-dione and evaluated for their in vitro cytotoxic activity against carcinogenic cells. The new chemical structures were evidenced using spectroscopy (IR, NMR and MS) and elemental analysis. The results show that compounds imidazo[4,5-b]quinoxaline-indolinone, thiazolopyrimidine-oxoindoline, pyrimidine-oxoindoline-hydrazine-carboxamide, spiro[indoline-3,2′-[1,3,4] thiadiazol]-one and spiro[indoline-3,3′-[1,2,4]triazolidin]-one have excellent anti-proliferative activities against different human cancer cell lines such as gastric carcinoma cells (MGC-803), breast adenocarcinoma cells (MCF-7), nasopharyngeal carcinoma cells (CNE2) and oral carcinoma cells (KB).
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Zhou, Xiao-Yu, Xia Chen, Liang-Guang Wang, Dan Yang, and Zhi Li. "Palladium-Catalyzed Oxidation-Hydroxylation and Oxidation-Methoxylation­ of N-Boc Indoles for the Synthesis of 3-Oxoindolines." Synthesis 49, no. 16 (2017): 3662–69. http://dx.doi.org/10.1055/s-0036-1589032.

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The palladium-catalyzed oxidation-hydroxylation and oxidation-methoxylation of N-Boc indoles for the synthesis of tert-butyl 2-hydroxy(methoxy)-3-oxoindoline-1-carboxylates and their derivatives is developed. The process occurs readily using PdCl2 as the catalyst and acetonitrile as the solvent to afford 3-oxoindolines in moderate to high yields. A mechanism for this Pd-catalyzed oxidation-hydroxylation and oxidation-methoxylation of N-Boc indoles is proposed.
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Anna, Markina, and Mishсhenko Oksana. "The influence of indolinoren on kidney function in conditions of water and salt load." ScienceRise: Pharmaceutical Science, no. 4(14) (August 31, 2018): 20–23. https://doi.org/10.15587/2519-4852.2018.141304.

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Diuretics are widely used to correct kidney disorders. In turn, the ionic composition of food, mostly sodium ions, which directly affect the excretory function of the kidneys, can act as modulators of the action of diuretics. The aim of the study was to investigate the effects of the new 2-oxoindoline derivative with the conventional name "Indolinoren" on the state of the excretory function of the kidneys under the conditions of water and salt load. Materials and methods. Studies were performed on white non-linear rats. The water load was modelled by introducing distilled water (5 ml per 100 g of body weight of the animal); salt load - intragastric administration of 0.45 % sodium chloride solution in an amount of 3 % of body weight. Indolinoren and comparison drug furosemide were administered intragastrically at a dose of 29.5 mg / kg and 5 mg / kg, respectively. Results and discussion. It has been established that indolinoren has a saluretic effect in conditions of water load, accompanied by an increase in sodium excretion by 132 % and potassium by 2.4 %. Against the background of the introduction of indolinoren, a significant increase in the sodium-potassium coefficient of urine was established 2.3-fold (p <0.05), which indicates a more pronounced natriuresis than kaliuresis. Under conditions of salt load, indolinoren promotes a significant increase in urine output by 381 % (p <0.05), increases sodium excretion by 127 % (p <0.05), potassium by 7 %. There were no significant differences in creatinine excretion. The expression of diuretic activity in conditions of salt load indolinoren exceeds furosemide and does not have a significant difference under conditions of water load. Conclusion: The increase in natriuresis and, to a lesser extent, the kaliuresis, as well as the absence of significant changes in the excretion of creatinine, a glomerular filtration marker, on the background of the introduction of indolinoren indicates that its diuretic effect is realized due to oppression of tubular reabsorption. In the mechanism of indolinoren action involved inhibition of mineralocorticoid control of the excretory function of the kidney, as evidenced by the increase in the sodium-potassium coefficient of urine. The obtained data justify the need for further in-depth study of indolinoren as a perspective diuretic
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4

Markina, А. Yu, and O. Ya Mishсhenko. "The study of the peculiarities of the diuretic action of 2-oxoindoline acylated derivative – N-[(2-oxoindoliniliden-3)-2-oxyacetyl]-valine propyl ester-[(2-oxoindoliniliden-3)-2-oxyacetyl]-valine propyl este." Klìnìčna farmacìâ 22, no. 3 (2018): 17–21. http://dx.doi.org/10.24959/cphj.18.1469.

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Bilovol, O. M., R. V. Lutsenko, I. I. Knyazkova, S. V. Kolisnyk, and E. G. Shakina. "THE INFLUENCE OF 2-OXOINDOLINE-3-GLYOXYLIC ACID DERIVATIVES ON THE NEUROPHYSIOLOGICAL REACTIONS OF RATS IN THE “BLACK AND WHITE CHAMBER” TEST." Medical and Ecological Problems 27, no. 5-6 (2023): 13–18. http://dx.doi.org/10.31718/mep.2023.27.5-6.02.

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The number of patients with an anxiety pathology is constantly growing, which requires the search and development of new remedies for protection. The aim of this research is to establish the presence of anxiolytic activity in derivatives of 2-oxoindolin-3-glyoxylic acid basedon testing animals in the “black-and-white chamber” test. Materials and methods. Experiments were performed on 150 adult male rats. The 2-oxoindoline derivatives were suspended ex tempore (water for injection and Tween-80) and administered to rats at a dose of 12 mg/kg intraperitoneally 1 hour before testing. The control group received a solvent with an emulsifier. Diazepam (2 mg/kg) served as a reference preparation. Behavior was studied in the “black and white chamber” test. Results. Compound 2 significantly reduced the residence time in the light compartment of the chamber. Substance 18 reduced the latent period of the first peek by 1.4 times (p<0.01), significantly increased the number and time of peeking, reduced the latent period of exit by 1.6 times (p<0.001), increased the number of exits and the time spent in the illuminated part of the device and significantly increased the percentage of rats peeking or exiting from the dark compartment and also reduced the number of boluses by 1.9-fold (p<0.001) compared to the control. Substance 2-T only increased the total time of peeking, compound K significantly reduced the number of boluses, and compound 3.85 increased the latent period of the first peek by 1.5 times (p<0.002), substance G increased the number of peeks by 1.7 times ( p<0.05), the time of stay in the light compartment of the camera by 2.5 times (p<0.001) and reduced the number of boluses by 1.3 times compared to the injection control (p<0.05). Conclusion. Administration of the IK compound significantly prolonged the latency of the first peek and exit, as well as significantly reduced the number of boluses compared to the control. 100% of animals peeked into the illuminated compartment of the chamber. Derivatives of 2-oxoindoline with the laboratory codes 18, G, and IК changed the neurophysiological reactions of animals in a similar way to the classic anxiolytic diazepam.
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Morteza, Shiri, Farajpour Behnaz, Bozorgpour-Savadjani Zahra, et al. "Transition-metal free highly selective aerobic oxidation of hindered 2-alkylindoles." Tetrahedron 71, no. 34 (2015): 5531–37. https://doi.org/10.1016/j.tet.2015.06.065.

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A novel and easy access to highly complex 3-oxoindolin-2-ylidene derivatives from the exposure of Ugiadducts bearing an indolyl moiety in Cs2CO3/DMF to air is reported. This is the first example of aerobic oxidation of 2-alkylindoles to 3-oxoindolin-2-ylidenes. Some advantages of this method are the use of air as oxygen source, transition metal-free reagents and simple conditions, a multicomponent and one-pot process and highly regioand stereoselective manner to trans-3-oxoindolin-2-ylidenes.
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Ravikumar, Krishnan, Balasubramanian Sridhar, Jagadeesh Babu Nanubolu, Tamilselvan Rajasekaran та Basi Venkata Subba Reddy. "Four oxoindole-linked α-alkoxy-β-amino acid derivatives". Acta Crystallographica Section C Structural Chemistry 71, № 4 (2015): 322–29. http://dx.doi.org/10.1107/s2053229615005604.

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Four structures of oxoindolyl α-hydroxy-β-amino acid derivatives, namely, methyl 2-{3-[(tert-butoxycarbonyl)amino]-1-methyl-2-oxoindolin-3-yl}-2-methoxy-2-phenylacetate, C24H28N2O6, (I), methyl 2-{3-[(tert-butoxycarbonyl)amino]-1-methyl-2-oxoindolin-3-yl}-2-ethoxy-2-phenylacetate, C25H30N2O6, (II), methyl 2-{3-[(tert-butoxycarbonyl)amino]-1-methyl-2-oxoindolin-3-yl}-2-[(4-methoxybenzyl)oxy]-2-phenylacetate, C31H34N2O7, (III), and methyl 2-[(anthracen-9-yl)methoxy]-2-{3-[(tert-butoxycarbonyl)amino]-1-methyl-2-oxoindolin-3-yl}-2-phenylacetate, C38H36N2O6, (IV), have been determined. The diastereoselectivity of the chemical reaction involving α-diazoesters and isatin imines in the presence of benzyl alcohol is confirmed through the relative configuration of the two stereogenic centres. In esters (I) and (III), the amide group adopts ananticonformation, whereas the conformation issynin esters (II) and (IV). Nevertheless, the amide group forms intramolecular N—H...O hydrogen bonds with the ester and ether O atoms in all four structures. The ether-linked substituents are in the extended conformation in all four structures. Ester (II) is dominated by intermolecular N—H...O hydrogen-bond interactions. In contrast, the remaining three structures are sustained by C—H...O hydrogen-bond interactions.
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Tiwari, Shailee V., Julio A. Seijas, M. Pilar Vazquez-Tato, and Anna Pratima G. Nikalje. "Ultrasound Assisted Synthesis of Diethyl (2-(1-(morpholinomethyl)-2-Oxoindolin-3-ylidene)hydrazinyl) (Substituted Phenyl/heteryl) MethylphosphonateDerivatives." Proceedings 9, no. 1 (2018): 3. http://dx.doi.org/10.3390/ecsoc-22-05790.

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This work reports ultrasound assisted synthesis diethyl (2-(1-(morpholinomethyl)-2-oxoindolin-3-ylidene)hydrazinyl) (substituted phenyl/heteryl) methylphosphonate 9(a–j) derivatives. The derivatives are synthesized using a green protocol. In the first step, 3-hydrazonoindolin-2-one is synthesized using ultrasound. In the second step, diethyl (substituted phenyl/heteryl)(2-(2-oxoindolin-3-ylidene)hydrazinyl) methylphosphonate 6(a–j) derivatives are synthesized using cerric ammonium nitrate as catalyst. In the third step, diethyl (2-(1-(morpholinomethyl)-2-oxoindolin-3-ylidene)hydrazinyl) (substituted phenyl/heteryl) methylphosphonate 9(a–j) derivatives are synthesized using ultrasound. Isatin, chemically known as H-indole-2,3-dione, and its derivatives possess a broad range of biological and pharmacological properties. Isatin is widely used as a starting material for the synthesis of a broad range of heterocyclic compounds and as substrates for drug synthesis. The α-amino phosphonate derivatives constitute an important class of organophosphorus compounds on account of their versatile biological activity. Morpholine moiety has been found to be an eminent pharmacophore in medicinal chemistry. A number of molecules possessing morpholine moiety are clinically approved drugs. The importance of this ring is well understood by medicinal chemists, since they play a major role in molecular properties such as an electronic distribution, three dimensionality, scaffold flexibility/rigidity, lipophilicity or polarity and metabolic stability. Considering the importance of the three pharmacophores, this promoted us to club these pharmacophores together in a single molecule using a green synthetic protocol.The structures of the ultrasound synthesized compounds were confirmed by spectral analysis like IR, 1H NMR, 13C NMR, 31P NMR and MS.
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Verma, Neetu, Vinay Kumar Mishra, Sundaram Singh, Manisha Malviya, and Ram Sagar. "Electro-organic green synthesis of dicyano-2-(2-oxoindolin-3-ylidene) malononitriles using molecular iodine as catalyst." RSC Advances 13, no. 22 (2023): 15024–30. http://dx.doi.org/10.1039/d3ra02152a.

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The first electrochemical molecular iodine promoted, domino reactions for the green synthesis of biologically relevant dicyano 2-(2-oxoindolin-3-ylidene) malononitriles from readily available isatin derivatives and malononitrileat room temperature has been presented.
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Slyvka, N. Yu, L. M. Saliyeva, V. I. Zhylko, V. M. Tkachuk, and M. V. Vovk. "Synthesis and antioxidant activity of new 2-(2-oxoindoline-3-ylydene) substituted 5,6-dihydroimidazo[2,1-b]thiazolones and 6,7-dihydro-thiazolo[3,2-a]pyrimidinones." Voprosy Khimii i Khimicheskoi Tekhnologii, no. 1 (February 2025): 71–79. https://doi.org/10.32434/0321-4095-2025-158-1-71-79.

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The paper presents the results of the study on the interaction of 5,6-dihydroimidazo[2,1-b]thiazoles and 6,7-dihydrothiazolo[3,2-a]pyrimidines with isatin derivatives. It was established that the condensation of the indicated reagents occurs selectively upon heating and without the use of a catalyst with the formation of addition products, 2-(2-oxoindolin-3-ylidene)-5,6-dihydroimidazo[2,1-b]thiazole-3(2H)-ones 6a–d and 2-(2-oxoindolin-3-ylidene)-6,7-dihydro-2H-thiazolo[3,2-a]pyrimidin-3(5H)-ones 7a–c, the structure of which was rigorously proven by 1H NMR (13C) spectroscopy and chromatography-mass spectrometry. All newly synthesized compounds were tested for antioxidant activity. According to the conducted bioscreening, the compounds 2-(5-nitro-2-oxoindolin-3-ylidene)-5,6-dihydroimidazo[2,1-b]thiazol-3(2H)-one 6d (I=84.5%) and 2-(5-nitro-2-oxoindolin-3-ylidene)-6,7-dihydro-2H-thiazolo[3,2-a]pyrimidin-3(5H)-one 7c (I=79.1%) exhibit the highest antioxidant action. This proves that electron-acceptor substituents in the 5-position of the 2,3-dihydro-1H-indoledione fragment contribute to a significant increase in antioxidant activity.
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Dissertations / Theses on the topic "2-oxoindoline derivative"

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Bukataru, Yu S. "Influence of the derivative of 2-benzamido-2-(2-oxoindolin-3-iliden) acetic acid on the activity of free-radical processes in traumatic brain injury." Thesis, БДМУ, 2017. http://dspace.bsmu.edu.ua:8080/xmlui/handle/123456789/17345.

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Bukataru, J. S. "The study of the derivatives of 2-benzamide-2-(2-oxoindolin-3-iliden) acetic acid on the antihypoxic activity under the conditions of hypobaric hypoxia." Thesis, Буковинський державний медичний університет, 2014. http://dspace.bsmu.edu.ua:8080/xmlui/handle/123456789/7915.

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徐偉育. "Bis-1,4-[2-(2-oxoindolin-3-ylidene)malononitrile]benzene Derivatives for N-Channel Organic Field Effect Transistors." Thesis, 2018. http://ndltd.ncl.edu.tw/handle/5j2773.

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YEN, FENG-MING, and 顏豐明. "Bis-2,6-[2-(2-oxoindolin-3-ylidene)malononitrile]naphthalene Derivatives for Air Stable N-Channel Organic Field Effect Transistors." Thesis, 2018. http://ndltd.ncl.edu.tw/handle/9g3nd4.

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碩士<br>國立暨南國際大學<br>應用化學系<br>106<br>The development of air-stable n-type organic field-effect transistor (OFET) materials have attracted much attention owing to the necessity to combine them with air-stable p-type OFETs to fabricate organic complementary circuits have high performance. We have changed the previously published derivatives of dicyanomethylene substituted indol-2-one, adding naphthalene between dimers to increase their conjugation length and coplanarity. Design N-type semiconductor materials, which can be stable under ambient conditions. We have successfully synthesized BIMN-C2C6、BAIMN-C2C6 and BAIMN-C10C14, the difference among the three are whether there is an N atom replace the C atom on the benzene ring and the length of the alkyl chain. Then we investigated their thermo-stability, optical properties, electrochemical properties. To study the influence of the nitrogen substituent and alkyl chain on the electron-transporting properties of BIMN derivatives, top-contact bottom-gate OFETs were fabricated on PTS-modified SiO2 substrates. The thin films were characterized by atomic force microscopy (AFM) and X-ray diffraction (XRD) to elucidate the relationships between molecular structure, film morphology and crystallinity. Finally, the XRD spectra of BAIMN-C10C14 based film show good crystallinity, but the AFM image shows discontinuity between grains and the element efficiency is low. It is presumed that the concentration of the solution or the drag speed should be adjusted in the liquid phase process to make the semiconductor layer has good crystallinity and film continuity.
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李侃蔚. "Bis-2, 2'-[2-(2-oxoindolin-3-ylidene)malononitrile]thieno[3,2-b]thiophene Derivatives for Air Stable N-Channel Organic Field Effect Transistors." Thesis, 2018. http://ndltd.ncl.edu.tw/handle/3pyg35.

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碩士<br>國立暨南國際大學<br>應用化學系<br>106<br>Organic Field-Effect Transistors (OFETs) have been studied for many years, because of their potential applications in large area, flexible, and low cost complementary circuits. The carrier mobility and device stability of N-type is far behind than P-type, this is because of the LUMO of organic materials is higher than H2O and oxygen. In this study we demonstrate the Bis-2,2’[2-(2-oxoindolin-3-ylidene)malononitrile]thieno[3,2-b]thiophene (BIMTT) derivatives and introduce cyano group onto isatins derivative is decrease the LUMO value, and make sure it becomes air-stable N-type OFET material. We success synthesis of BIMTT-C2C6、BAIMTT-C2C6、BAIMTT-C6C10 and BFTMTT-C6C10, the LUMO value is -4.00, -4.06, -4.02 and -4.03 eV calculate by cyclic voltammetry (CV), is lower than -3.8 eV, showed air-stable, the energy gap is 1.62, 1.44, 1.69 and 1.58 eV. In order to investigate the charge transport properties of BIMTT derivatives, we create devices by vapor deposition and solution process. The thin films were characterized by atomic force microscopy (AFM) and X-ray diffraction (XRD) to elucidate the relationships between molecular structure, film morphology, and device performance. In vapor deposition showed the XRD peak is weak, because of the molecular weight is too heavy to deposition. In solution process AFM showed the surface morphology is more rough when the bar move more quickly. Because of the film is not continuity which is showed on AFM and XRD spectroscopy. So all materials in this study not show the semiconductor property.
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YANG, TING-HSUANG, and 楊庭軒. "Design, Synthesis and Evaluation of Novel 2-Pyrrolidone-Fused (2-Oxoindolin-3-ylidene)methylpyrrole Derivatives as Potential Anti-angiogenesis Agents." Thesis, 2017. http://ndltd.ncl.edu.tw/handle/sn5639.

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博士<br>國防醫學院<br>醫學科學研究所<br>106<br>Signaling pathways of VEGFs and PDGFs are crucial in tumor angiogenesis, which is essential in solid tumor progression and metastasis. This study reports our strategy for design and synthesis of a series of novel 2-pyrrolidone-fused (2-oxoindolin-3-ylidene)methylpyrrole derivatives as potential multi-target tyrosine kinase receptor inhibitors. The target compounds were obtained by condensation of 5-substituted oxindoles with N-substituted 2-pyrrolidone aldehyde 7 in satisfactory yields. Of these, 11, 12, 23 and 24 had the highest potency and, compared to sunitinib, showed: (1) significant increase in anti-proliferation of various cancer cells with a favorable selective index (SI); (2) higher inhibitory potency against both VEGFR-2 and PDGFRβ. The molecular modeling results showed that, in terms of VEGFR-2 binding, the synthetic products had a similar binding mode to sunitinib but with tighter interaction. The experimental results suggest that 11, 12, 23 and 24 might be promising anti-angiogenesis agents.
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Conference papers on the topic "2-oxoindoline derivative"

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Nikalje, Anna Pratima, Shailee Tiwari, Rekha Gajare, Julio Seijas Vázquez, and M. Pilar Vazquez-Tato. "Kabachnik–Fields synthesis of novel 2-oxoindolin methyl phosphonate derivatives using CAN." In The 21st International Electronic Conference on Synthetic Organic Chemistry. MDPI, 2017. http://dx.doi.org/10.3390/ecsoc-21-04756.

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