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Journal articles on the topic '2-Plectic'

Author: Grafiati

Published: 8 June 2024

Last updated: 31 July 2025

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1

SHAFIEE, M. "2-PLECTIC MANIFOLDS AND ITS RELATION WITH COURANT ALGEBROIDS." International Journal of Geometric Methods in Modern Physics 09, no. 03 (2012): 1250015. http://dx.doi.org/10.1142/s0219887812500156.

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In this paper we study the relation between 2-plectic manifolds and Courant algebroids. We establish a relation between 2-Lagrangian submanifolds of 2-plectic manifolds and subbundles of Courant algebroids. Also we show that an action of a compact Lie group G on a 2-plectic manifold (M, ω) can be extended to an action of G on an exact Courant algebroid E over M if and only if G is a subgroup of Hamiltonian group of (M, ω).

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2

SÄMANN, CHRISTIAN, and RICHARD J. SZABO. "GROUPOIDS, LOOP SPACES AND QUANTIZATION OF 2-PLECTIC MANIFOLDS." Reviews in Mathematical Physics 25, no. 03 (2013): 1330005. http://dx.doi.org/10.1142/s0129055x13300057.

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We describe the quantization of 2-plectic manifolds as they arise in the context of the quantum geometry of M-branes and non-geometric flux compactifications of closed string theory. We review the groupoid approach to quantizing Poisson manifolds in detail, and then extend it to the loop spaces of 2-plectic manifolds, which are naturally symplectic manifolds. In particular, we discuss the groupoid quantization of the loop spaces of ℝ3, 𝕋3and S3, and derive some interesting implications which match physical expectations from string theory and M-theory.

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3

Shafiee, Mohammad. "A note on $2$-plectic homogeneous manifolds." Journal of Geometric Mechanics 7, no. 3 (2015): 389–94. http://dx.doi.org/10.3934/jgm.2015.7.389.

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4

Rogers, Christopher L. "2-Plectic geometry, Courant algebroids, and categorified prequantization." Journal of Symplectic Geometry 11, no. 1 (2013): 53–91. http://dx.doi.org/10.4310/jsg.2013.v11.n1.a4.

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5

Shafiee, Mohammad. "The 2-plectic structures induced by the Lie bialgebras." Journal of Geometric Mechanics 9, no. 1 (2017): 83–90. http://dx.doi.org/10.3934/jgm.2017003.

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6

Shafiee, Mohammad. "On compact semisimple Lie groups as 2-plectic manifolds." Journal of Geometry 105, no. 3 (2014): 615–23. http://dx.doi.org/10.1007/s00022-014-0223-5.

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7

Krepski, Derek. "Lie 2-algebras of symmetries of U(1)-bundle gerbes." Journal of Physics: Conference Series 2667, no. 1 (2023): 012035. http://dx.doi.org/10.1088/1742-6596/2667/1/012035.

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Abstract This is a brief survey of some recent results on infinitesimal symmetries of bundle gerbes and their relation to three Lie 2-algebras associated to manifolds equipped with a closed 3-form, such as 2-plectic manifolds: the Poisson Lie 2-algebra of local observables, the Lie 2-algebra of sections of an associated exact Courant algebroid, and the Atiyah Lie 2-algebra.

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8

Bunk, Severin. "Gerbes in Geometry, Field Theory, and Quantisation." Complex Manifolds 8, no. 1 (2021): 150–82. http://dx.doi.org/10.1515/coma-2020-0112.

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Abstract This is a mostly self-contained survey article about bundle gerbes and some of their recent applications in geometry, field theory, and quantisation. We cover the definition of bundle gerbes with connection and their morphisms, and explain the classification of bundle gerbes with connection in terms of differential cohomology. We then survey how the surface holonomy of bundle gerbes combines with their transgression line bundles to yield a smooth bordism-type field theory. Finally, we exhibit the use of bundle gerbes in geometric quantisation of 2-plectic as well as 1- and 2-shifted s

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Xu, Rushuang, Shan He, Di Ma, Rui Liang, Qing Luo, and Guanbin Song. "Plectin Downregulation Inhibits Migration and Suppresses Epithelial Mesenchymal Transformation of Hepatocellular Carcinoma Cells via ERK1/2 Signaling." International Journal of Molecular Sciences 24, no. 1 (2022): 73. http://dx.doi.org/10.3390/ijms24010073.

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Plectin, as a cytoskeleton-related protein, is involved in various physiological and pathological processes of many cell types. Studies have found that plectin affects cancer cell invasion and metastasis, but the exact mechanism is not fully understood. In this study, we aim to investigate the role of plectin in the migration of hepatocellular carcinoma (HCC) cells and explore its relevant molecular mechanism. Herein, we found that the expression of plectin in HCC tissue and cells was significantly increased compared with normal liver tissue and cells. After downregulation of plectin, the migr

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10

Foisner, R., B. Feldman, L. Sander, and G. Wiche. "Monoclonal antibody mapping of structural and functional plectin epitopes." Journal of Cell Biology 112, no. 3 (1991): 397–405. http://dx.doi.org/10.1083/jcb.112.3.397.

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To map structural and functional epitopes of the cytomatrix protein plectin, a set of mAbs was prepared by immunization of mice. Using immunoblot analysis of plectin fragments obtained after limited digestion with various proteases, two groups of mAbs were distinguished. The epitopes of one group (1) were located on a 130-kD terminal segment of the plectin 300-kD polypeptide chain, whereas those of the other group (2) bound within a 40kD segment confined to a central domain of the polypeptide chain. Domains containing the epitopes of group 2 mAbs were shown to include in vitro phosphorylation

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Litjens, Sandy H. M., Jan Koster, Ingrid Kuikman, Sandra van Wilpe, José M. de Pereda та Arnoud Sonnenberg. "Specificity of Binding of the Plectin Actin-binding Domain to β4 Integrin". Molecular Biology of the Cell 14, № 10 (2003): 4039–50. http://dx.doi.org/10.1091/mbc.e03-05-0268.

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Plectin is a major component of the cytoskeleton and links the intermediate filament system to hemidesmosomes by binding to the integrin β4 subunit. Previously, a binding site for β4 was mapped on the actin-binding domain (ABD) of plectin and binding of β4 and F-actin to plectin was shown to be mutually exclusive. Here we show that only the ABDs of plectin and dystonin bind to β4, whereas those of other actin-binding proteins do not. Mutations of the ABD of plectin-1C show that Q131, R138, and N149 are critical for tight binding of the ABD to β4. These residues form a small cavity, occupied by

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12

Osmanagic-Myers, Selma, Martin Gregor, Gernot Walko, Gerald Burgstaller, Siegfried Reipert, and Gerhard Wiche. "Plectin-controlled keratin cytoarchitecture affects MAP kinases involved in cellular stress response and migration." Journal of Cell Biology 174, no. 4 (2006): 557–68. http://dx.doi.org/10.1083/jcb.200605172.

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Plectin is a major intermediate filament (IF)–based cytolinker protein that stabilizes cells and tissues mechanically, regulates actin filament dynamics, and serves as a scaffolding platform for signaling molecules. In this study, we show that plectin deficiency is a cause of aberrant keratin cytoskeleton organization caused by a lack of orthogonal IF cross-linking. Keratin networks in plectin-deficient cells were more susceptible to osmotic shock–induced retraction from peripheral areas, and their okadaic acid–induced disruption (paralleled by stress-activated MAP kinase p38 activation) proce

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13

Fujiwara, S., and N. Takeo. "051 Carboxy-terminal structure of plectin-2." Journal of Dermatological Science 15, no. 2 (1997): 111. http://dx.doi.org/10.1016/s0923-1811(97)81755-0.

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14

Nievers, M. G., I. Kuikman, D. Geerts, I. M. Leigh, and A. Sonnenberg. "Formation of hemidesmosome-like structures in the absence of ligand binding by the (alpha)6(beta)4 integrin requires binding of HD1/plectin to the cytoplasmic domain of the (beta)4 integrin subunit." Journal of Cell Science 113, no. 6 (2000): 963–73. http://dx.doi.org/10.1242/jcs.113.6.963.

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Hemidesmosomes are adhesion structures that mediate anchorage of epithelial cells to the underlying basement membrane. We have previously shown that the (alpha)6(beta)4 integrin can induce the assembly of these multi-protein structures independent of binding to its ligand laminin-5 (ligand-independent formation of hemidesmosomes). Our results suggested a role for HD1/plectin, which binds to the cytoplasmic domain of the (beta)4 integrin subunit, in controlling the clustering of hemidesmosomal components at the basal side of the cell. Using keratinocytes derived from patients lacking HD1/plecti

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15

Wilhelmsen, Kevin, Sandy H. M. Litjens, Ingrid Kuikman, et al. "Nesprin-3, a novel outer nuclear membrane protein, associates with the cytoskeletal linker protein plectin." Journal of Cell Biology 171, no. 5 (2005): 799–810. http://dx.doi.org/10.1083/jcb.200506083.

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Despite their importance in cell biology, the mechanisms that maintain the nucleus in its proper position in the cell are not well understood. This is primarily the result of an incomplete knowledge of the proteins in the outer nuclear membrane (ONM) that are able to associate with the different cytoskeletal systems. Two related ONM proteins, nuclear envelope spectrin repeat (nesprin)–1 and –2, are known to make direct connections with the actin cytoskeleton through their NH2-terminal actin-binding domain (ABD). We have now isolated a third member of the nesprin family that lacks an ABD and in

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16

Wolf, Cody L., Roxanne K. Ruiz, Julien Dimastromatteo, Samantha Perez, Matthew J. Reilley, and Kimberly A. Kelly. "Abstract 6885: Plectin as a novel therapeutic target for pancreatic cancer." Cancer Research 85, no. 8_Supplement_1 (2025): 6885. https://doi.org/10.1158/1538-7445.am2025-6885.

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Abstract Pancreatic ductal adenocarcinoma (PDAC) is the 3rd deadliest cancer in the United States with only a 5-year survival rate of 13%, demonstrating a desperate need for novel therapeutic targets to significantly enhance options for patients. In 2008, Kelly et al. pioneered a phage-display-based functional-proteomic approach and identified a cytolinker protein, plectin, which was mislocalized and ubiquitously expressed on the membrane of PDAC. This unique localization of plectin, called cell surface plectin (CSP), has since been found to be expressed on the cell surface of many cancer subt

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17

Holovachov, Oleksandr. "Swedish Plectida (Nematoda). Part 2. The genus Antomicron Cobb, 1920." Zootaxa 3380 (December 31, 2012): 39–54. https://doi.org/10.5281/zenodo.281718.

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18

Gu, Huimin, Lingyun Sun, and Yong Huang. "Two new species of Leptolaimus (Nematoda: Plectida) from Chinese sea area." Zootaxa 5507, no. 2 (2024): 384–94. https://doi.org/10.11646/zootaxa.5507.2.9.

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Gu, Huimin, Sun, Lingyun, Huang, Yong (2024): Two new species of Leptolaimus (Nematoda: Plectida) from Chinese sea area. Zootaxa 5507 (2): 384-394, DOI: 10.11646/zootaxa.5507.2.9, URL: http://dx.doi.org/10.11646/zootaxa.5507.2.9

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HOLOVACHOV, OLEKSANDR. "Swedish Plectida (Nematoda). Part 2. The genus Antomicron Cobb, 1920." Zootaxa 3380, no. 1 (2012): 39. http://dx.doi.org/10.11646/zootaxa.3380.1.3.

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Two new species of Antomicron are described from bottom sediments collected in Gullmarn Fjord, west coast of Sweden.A. quindecimpapillatus sp. n. is particularly characterised by the 1390–1459 µm long body; elongate doughnut-shapedamphid; straight vagina with drop-shaped sclerotizations; female without sensilla in pharyngeal region and without sup-plements; male with two pairs of setiform sensilla in pharyngeal region, 15 tubular and no alveolar supplements, one pairof precloacal and four pairs of caudal setae, 26.0–29.5 µm long spicules. A. lorenzeni sp. n. is particularly characterisedby the

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20

Song, Jae-Geun, Julius Kostan, Friedel Drepper та ін. "Structural Insights into Ca 2+ -Calmodulin Regulation of Plectin 1a-Integrin β4 Interaction in Hemidesmosomes". Structure 23, № 3 (2015): 558–70. http://dx.doi.org/10.1016/j.str.2015.01.011.

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21

Yin, Huadong, Shunshun Han, Can Cui, Yan Wang, Diyan Li, and Qing Zhu. "Plectin regulates Wnt signaling mediated-skeletal muscle development by interacting with Dishevelled-2 and antagonizing autophagy." Gene 783 (May 2021): 145562. http://dx.doi.org/10.1016/j.gene.2021.145562.

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22

Henzler, Tanja, Abdallah Harmache, Harald Herrmann, et al. "Fully functional, naturally occurring and C-terminally truncated variant human immunodeficiency virus (HIV) Vif does not bind to HIV Gag but influences intermediate filament structure." Journal of General Virology 82, no. 3 (2001): 561–73. http://dx.doi.org/10.1099/0022-1317-82-3-561.

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A variant human immunodeficiency virus type 1 (HIV-1) vif gene, vifA45-2, which encodes a protein lacking 19 amino acids at the C terminus but which is fully functional in supporting HIV replication in non-permissive cells has been described previously. By employing newly generated anti-VifA45 serum, further properties of VifA45 and its full-length counterpart, VifA45open, in comparison to Vif from HIV strain BH10 are reported in permissive HeLa and COS-7 cells. The results obtained using confocal microscopic localization studies and in vitro binding assays do not support a requirement for the

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23

Nievers, M. G., R. Q. Schaapveld, L. C. Oomen, L. Fontao, D. Geerts, and A. Sonnenberg. "Ligand-independent role of the beta 4 integrin subunit in the formation of hemidesmosomes." Journal of Cell Science 111, no. 12 (1998): 1659–72. http://dx.doi.org/10.1242/jcs.111.12.1659.

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Recently, we have shown that a region within the beta4 cytoplasmic domain, encompassing the second fibronectin type III (FNIII) repeat and the first 27 amino acids of the connecting segment, is critical for the localization of alpha6 beta4 in hemidesmosomes. In addition, this region was shown to regulate the distribution of HD1/plectin in transfected cells. In order to investigate the function of the beta4 extracellular and cytoplasmic domains in the assembly and integrity of hemidesmosomes, we have constructed chimeric receptors consisting of the extracellular and transmembrane domains of the

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24

Dong, Wenyu, Zhi Cai, Jing Pang, et al. "Radiotherapy Enhancement for Human Pancreatic Carcinoma Using a Peptide-Gold Nanoparticle Hybrid." Journal of Biomedical Nanotechnology 16, no. 3 (2020): 352–63. http://dx.doi.org/10.1166/jbn.2020.2898.

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Pancreatic ductal adenocarcinoma (PDAC) is radioresistant. Due to their strong X-ray absorption capacity, gold nanoparticles (AuNPs) have been used as radiosensitizers for cancer therapeutics. Herein, we describe a novel conjugate complex consisting of a peptide for targeting plectin-1 (PTP) specifically expressed on the PDAC cell membrane and AuNPs, termed AuNP-PTP, to be used for PDAC radiotherapy in vitro and in vivo. Previous studies revealed that compared with unmodified AuNPs, AuNP-PTP along with relevant low-energy X-ray irradiation of 6 MV at a dose of 2 Gy (RF) increased the targeting

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25

Arshad, Jahanzaib, Kelvin K. H. Tong, Sanam Movassaghi, et al. "Impact of the Metal Center and Leaving Group on the Anticancer Activity of Organometallic Complexes of Pyridine-2-carbothioamide." Molecules 26, no. 4 (2021): 833. http://dx.doi.org/10.3390/molecules26040833.

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RuII(cym)Cl (cym = η6-p-cymene) complexes of pyridinecarbothioamides have shown potential for development as orally active anticancer metallodrugs, underlined by their high selectivity towards plectin as the molecular target. In order to investigate the impact of the metal center on the anticancer activity and their physicochemical properties, the Os(cym), Rh- and Ir(Cp*) (Cp* = pentamethylcyclopentadienyl) analogues of the most promising and orally active compound plecstatin 2 were prepared and characterized by spectroscopic techniques and X-ray diffraction analysis. Dissolution in aqueous me

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26

Koh, Timothy J., and Joel Escobedo. "Cytoskeletal disruption and small heat shock protein translocation immediately after lengthening contractions." American Journal of Physiology-Cell Physiology 286, no. 3 (2004): C713—C722. http://dx.doi.org/10.1152/ajpcell.00341.2003.

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The purposes of this study were to determine whether, immediately after lengthening contractions, 1) levels of specific force-transmitting cytoskeletal elements are reduced in skeletal muscle cells and 2) cytosolic small heat shock proteins (HSPs) translocate to structures prone to disruption. Western blot analysis demonstrated decreased concentrations of z-disk proteins α-actinin and plectin and membrane scaffolding proteins dystrophin and β-spectrin in muscle exposed to lengthening contractions compared with contralateral control muscle. Lengthening contractions also resulted in immediate tr

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Ketema, Mirjam, and Arnoud Sonnenberg. "Nesprin-3: a versatile connector between the nucleus and the cytoskeleton." Biochemical Society Transactions 39, no. 6 (2011): 1719–24. http://dx.doi.org/10.1042/bst20110669.

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The cytoskeleton is connected to the nuclear interior by LINC (linker of nucleoskeleton and cytoskeleton) complexes located in the nuclear envelope. These complexes consist of SUN proteins and nesprins present in the inner and outer nuclear membrane respectively. Whereas SUN proteins can bind the nuclear lamina, members of the nesprin protein family connect the nucleus to different components of the cytoskeleton. Nesprin-1 and -2 can establish a direct link with actin filaments, whereas nesprin-4 associates indirectly with microtubules through its interaction with kinesin-1. Nesprin-3 is the o

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28

Sommerhalder, David, Sarina A. Piha-Paul, Meredith Pelster, et al. "A phase 1/2, first-in-human trial of ZB131, a novel antibody targeting cancer-specific plectin (CSP) in advanced solid tumors." Journal of Clinical Oncology 41, no. 16_suppl (2023): 3083. http://dx.doi.org/10.1200/jco.2023.41.16_suppl.3083.

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3083 Background: Cancer-Specific Plectin (CSP) is a novel pro-tumorigenic target that is selectively expressed on the surface of tumors, while absent from benign tissue. CSP is highly expressed in many solid cancers, particularly pancreatic (PC), cholangiocarcinoma (CCA), and ovarian (OC). ZB131 (Zielbio), is a humanized anti-CSP IgG1 monoclonal antibody that binds specifically to CSP on the surface of tumor cells, rapidly internalizes and modulates key proliferative and cytoskeletal remodeling signaling pathways to decrease cancer cell growth and increase the recruitment of anti-tumor immune

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Filiou, Michaela D., Larysa Teplytska, Markus Nussbaumer, David-M. Otte, Andreas Zimmer, and Christoph W. Turck. "Multi-Omics Analysis Reveals Myelin, Presynaptic and Nicotinate Alterations in the Hippocampus of G72/G30 Transgenic Mice." Journal of Personalized Medicine 12, no. 2 (2022): 244. http://dx.doi.org/10.3390/jpm12020244.

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The primate-specific G72/G30 gene locus has been associated with major psychiatric disorders, such as schizophrenia and bipolar disorder. We have previously generated transgenic mice which carry the G72/G30 locus and express the longest G72 splice variant (LG72) protein encoded by this locus with schizophrenia-related symptoms. Here, we used a multi-omics approach, including quantitative proteomics and metabolomics to investigate molecular alterations in the hippocampus of G72/G30 transgenic (G72Tg) mice. Our proteomics analysis revealed decreased expression of myelin-related proteins and NAD-

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Preisz, Klaudia, and Sarolta Kárpáti. "Paraneoplastic pemphigus." Orvosi Hetilap 148, no. 21 (2007): 979–83. http://dx.doi.org/10.1556/oh.2007.27955.

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A paraneoplasticus pemphigus malignus vagy benignus tumorokhoz társuló autoimmun hólyagos megbetegedés diagnosztikus és immunológiai kritériumait 1990-ben fektette le Anhalt . Klinikailag súlyos, fájdalmas, mélyre terjedő bőr- és nyálkahártyatünetek jellemzik. A bőrtünetek polimorf jellegűek, általában dominál a hólyagképződés. Egyes esetekben, az ún. „graft-versus-host-disease” formákban előfordul, hogy kizárólag papulosus, lichenoid bőrtünetek észlelhetők, hólyagképződés nincs, vagy csak később jelenik meg. Elsősorban ezen alcsoport betegeiben a bőr- és nyálkahártyatünetek mellett súlyos dys

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Herrmann, H., and G. Wiche. "Plectin and IFAP-300K are homologous proteins binding to microtubule-associated proteins 1 and 2 and to the 240-kilodalton subunit of spectrin." Journal of Biological Chemistry 262, no. 3 (1987): 1320–25. http://dx.doi.org/10.1016/s0021-9258(19)75789-5.

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Zhylina, T. M., та V. L. Shevchenko. "УГРУПОВАННЯ ПІДСТИЛКОВИХ НЕМАТОД ЛІСІВ МЕЗИНСЬКОГО НАЦІОНАЛЬНОГО ПРИРОДНОГО ПАРКУ". Scientific Issue Ternopil Volodymyr Hnatiuk National Pedagogical University. Series: Biology 77, № 3 (2019): 13–17. http://dx.doi.org/10.25128/2078-2357.19.3.2.

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The taxonomic structure of the nematodes and the thickness in the forest litter of the Mezin National Nature Park were studied. Samples were collected during 2008-2010 and 2014 (June – July) in 21 forest ecosystems. Nematodes were extracted by a modified Baermann's method from the sample of 5 g. The exposition time was 48 h. Extracted nematodes were fixed in the triethanolamine–formalin (TAF, 2 % triethanolamine, 7 % formaldehyde solution, 91 % water), and mounted on the temporary hydroglyceric slides.  To describe the taxonomic structure of nematode communities we calculated the proport

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Sun, D., C. L. Leung, and R. K. Liem. "Characterization of the microtubule binding domain of microtubule actin crosslinking factor (MACF): identification of a novel group of microtubule associated proteins." Journal of Cell Science 114, no. 1 (2001): 161–72. http://dx.doi.org/10.1242/jcs.114.1.161.

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MACF (microtubule actin cross-linking factor) is a large, 608-kDa protein that can associate with both actin microfilaments and microtubules (MTs). Structurally, MACF can be divided into 3 domains: an N-terminal domain that contains both a calponin type actin-binding domain and a plakin domain; a rod domain that is composed of 23 dystrophin-like spectrin repeats; and a C-terminal domain that includes two EF-hand calcium-binding motifs, as well as a region that is homologous to two related proteins, GAR22 and Gas2. We have previously demonstrated that the C-terminal domain of MACF binds to MTs,

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Rehmani, Taha, Ana Paula Dias, Billi Dawn Applin, Maysoon Salih, and Balwant S. Tuana. "SLMAP3 is essential for neurulation through mechanisms involving cytoskeletal elements, ABP, and PCP." Life Science Alliance 7, no. 12 (2024): e202302545. http://dx.doi.org/10.26508/lsa.202302545.

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SLMAP3 is a tail-anchored membrane protein that targets subcellular organelles and is believed to regulate Hippo signaling. The global loss of SLMAP3 causes late embryonic lethality in mice, with some embryos exhibiting neural tube defects such as craniorachischisis. We show here thatSLMAP3−/−embryos display reduced length and increased width of neural plates, signifying arrested convergent extension. The expression of planar cell polarity (PCP) components Dvl2/3 and the activity of the downstream targets ROCK2, cofilin, and JNK1/2 were dysregulated inSLMAP3−/−E12.5 brains. Furthermore, the cy

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Papineni, Rao V., Amitava Adhikary, and Santanu Bhattacharya. "Abstract 219: Towards targeted-gold nanoparticle enhanced chemoradiation therapy of pancreatic cancer." Cancer Research 82, no. 12_Supplement (2022): 219. http://dx.doi.org/10.1158/1538-7445.am2022-219.

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Abstract The goal of this project is to develop a unique pancreatic cancer treatment platform where, X-ray excited Targeted-Gold nanoparticles (T-GNPs) trigger and enhance drug action (I-RaGAZ, Integrated radiation combined with T-GNP and 2-Azido-2-deoxy-D-glucose (2-AZ-2-DG)). Herein, we plan to utilize a novel three stage nanotechnology-chemoradiation combinatorial approach for enhancing catastrophic cell death in pancreatic tumors and reducing normal tissue toxicity. T-GNP has cytotoxic effect at tumor site and can specifically sensitize tumor tissue for radiation. In this work, we used our

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Nguyen, Jordan, Tze Wei Chong, Hafsa Elmi, et al. "Role of Hemidesmosomes in Oral Carcinogenesis: A Systematic Review." Cancers 15, no. 9 (2023): 2533. http://dx.doi.org/10.3390/cancers15092533.

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Background: Oral cancers have limited diagnostic tools to aid clinical management. Current evidence indicates that alterations in hemidesmosomes, the adhesion complexes primarily involved in epithelial attachment to the basement membrane, are correlated to cancer phenotype for multiple cancers. This systematic review aimed to assess the experimental evidence for hemidesmosomal alterations, specifically in relation to oral potentially malignant disorders and oral squamous cell carcinomas. Methods: We conducted a systemic review to summarise the available literature on hemidesmosomal components

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Harris, T. J., D. R. Jones, C. M. Brenin, K. A. Kelly, K. George, and C. A. Moskaluk. "Evaluation of plectin-1 immunohistochemical staining in human non-small cell lung cancer." Journal of Clinical Oncology 27, no. 15_suppl (2009): e22118-e22118. http://dx.doi.org/10.1200/jco.2009.27.15_suppl.e22118.

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e22118 Background: Plectin-1 (PLEC1), a known scaffolding protein, impacts signaling pathways and has been found to be up-regulated and redistributed to the cell membrane in tumor cells. The redistribution of PLEC1 has shown promise as a novel molecular imaging biomarker in experimental systems. The purpose of this study was to examine the variation of PLEC1 staining in human non-small cell lung cancer (NSCLC). Methods: 142 NSCLC samples from 2001–2003 were obtained from pathology archives and placed into tissue microarray (TMA) format. TMA sections were stained with anti-PLEC1 antibody. A tot

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Pajenda, Sahra, Daniela Gerges, Ludwig Wagner, et al. "Identification of Pathogenic Pathways for Recurrence of Focal Segmental Glomerulosclerosis after Kidney Transplantation." Diagnostics 14, no. 15 (2024): 1591. http://dx.doi.org/10.3390/diagnostics14151591.

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Primary focal segmental glomerulosclerosis (FSGS) is a disease of the podocytes and glomerulus, leading to nephrotic syndrome and progressive loss of renal function. One of the most serious aspects is its recurrence of disease in over 30% of patients following allogeneic kidney transplantation, leading to early graft loss. This research investigates the individual genetic predispositions and differences in the immune responses leading to recurrence of FSGS after transplantation. We performed exome sequencing on six patients with recurrent FSGS to identify variants in fifty-one genes and found

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Kannarkat, G. J., T. Harris, K. Kelly, P. Fracasso, and C. Moskaluk. "Evaluation of plectin-1 immunohistochemical expression in human colon cancer tumor progression." Journal of Clinical Oncology 27, no. 15_suppl (2009): e22132-e22132. http://dx.doi.org/10.1200/jco.2009.27.15_suppl.e22132.

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e22132 Background: Plectin-1 (PLEC1), a known scaffolding protein, was recently discovered to be upregulated and redistributed to the cell membrane in multiple cancers, thereby providing a molecular imaging biomarker for disease detection. The purpose of this study was to examine PLEC1 staining in the tumor progression of human colorectal carcinoma. Methods: A tissue microarray of colonic neoplastic progression was stained with antibody to PLEC1. A total PLEC1 immunohistochemical (IHC) staining score was obtained by multiplying the intensity of PLEC1 membrane staining, scored 1 to 3, by the pe

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Tran, Thai Thanh, Nguyen Le Que Lam, Nguyen Thi My Yen, et al. "Using free-living nematode communities as biological monitoring of environmental quality status in Ben Tre city." Science and Technology Development Journal - Natural Sciences 4, no. 4 (2020): First. http://dx.doi.org/10.32508/stdjns.v4i4.866.

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Nematode communities were used as a tool to assess the environmental quality status of sediment of the water bodies in Ben Tre city. Eight locations in the main canals and river in the city were surveyed during the rainy season (September). The study recorded 51 genera belonging to 33 families, 10 orders (Araeolaimida, Chromadorida, Desmodorida, Dorylaimida, Enoplida, Monhysterida, Mononchida, Plectida, Rhabditida, and Triplonchida), 2 classes (Chromadorea and Enoplia). The density of nematode communities at most survey locations is quite high, ranging from 29.88 +/- 38.01 to 1172.08 +/- 659.7

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Pozuelo Rubio, Mercedes, David G. Campbell, Nicholas A. Morrice, and Carol Mackintosh. "Phosphodiesterase 3A binds to 14-3-3 proteins in response to PMA-induced phosphorylation of Ser428." Biochemical Journal 392, no. 1 (2005): 163–72. http://dx.doi.org/10.1042/bj20051103.

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PDE3A (phosphodiesterase 3A) was identified as a phosphoprotein that co-immunoprecipitates with endogenous 14-3-3 proteins from HeLa cell extracts, and binds directly to 14-3-3 proteins in a phosphorylation-dependent manner. Among cellular stimuli tested, PMA promoted maximal binding of PDE3A to 14-3-3 proteins. While p42/p44 MAPK (mitogen-activated protein kinase), SAPK2 (stress-activated protein kinase 2)/p38 and PKC (protein kinase C) were all activated by PMA in HeLa cells, the PMA-induced binding of PDE3A to 14-3-3 proteins was inhibited by the non-specific PKC inhibitors Ro 318220 and H-

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Sharma, Vipra, Sabyasachi Bandyopadhyay, Kapil Sikka, Aanchal Kakkar, Gururao Hariprasad, and Sundararajan Baskar Singh. "Label-Free Proteomics of Oral Mucosa Tissue to Identify Potential Biomarkers That Can Flag Predilection of Precancerous Lesions to Oral Cell Carcinoma: A Preliminary Study." Disease Markers 2023 (February 1, 2023): 1–16. http://dx.doi.org/10.1155/2023/1329061.

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Oral squamous cell carcinomas are mostly preceded by precancerous lesions such as leukoplakia and erythroplakia. Our study is aimed at identifying potential biomarker proteins in precancerous lesions of leukoplakia and erythroplakia that can flag their transformation to oral cancer. Four biological replicate samples from clinical phenotypes of healthy control, leukoplakia, erythroplakia, and oral carcinoma were annotated based on clinical screening and histopathological evaluation of buccal mucosa tissue. Differentially expressed proteins were delineated using a label-free quantitative proteom

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Жиліна, Тетяна, та Валентина Шевченко. "ФАУНА ГРУНТОВИХ НЕМАТОД ПРИБЕРЕЖНИХ СМУГ РІЧОК ЧЕРНІГІВСЬКОГО ПОЛІССЯ". Biota. Human. Technology, № 3 (6 березня 2023): 26–35. http://dx.doi.org/10.58407/bht.3.22.3.

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Мета роботи. Одержати відомості про таксономічну структуру угруповань ґрунтових нематод прибережних смуг річок Чернігівського Полісся. Методологія. Зразки ґрунту відбирали у 5 лучних екосистемах, які розташовані у прибережних смугах річок Ревна, Снов, Свишень, Десна та Дніпро у червні та липні 2014 року. Виділення нематод проводили лійковим методом Бермана з наважки 20 г. Експозиція становила 48 год., після чого нематод фіксували ТАФом (триетаноламін+формалін+вода у співвідношенні 2:7:91). Виготовляли тимчасові водно-гліцеринові мікропрепарати. Перерахунок чисельності здійснювали на 100 г абсо

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Perez, Samantha M., Brian P. Murphy, Danielle B. Heckert, et al. "Abstract 6299: ZB131 antibody-drug conjugates induce potent antitumor activity." Cancer Research 83, no. 7_Supplement (2023): 6299. http://dx.doi.org/10.1158/1538-7445.am2023-6299.

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Abstract Antibody-drug conjugates (ADCs) have become increasingly adopted clinically, with 13 drugs FDA-approved and over 100 under clinical development. Despite this momentum and major advances in payload and linker technology, ADCs are limited by off-cancer target-mediated toxicities incurred by currently available targets. In contrast to genomic and proteomic strategies, our unique drug discovery approach accounts for a disease’s native context. This led to the identification of cancer-specific plectin (CSP) as not only overexpressed in malignant tissue compared to healthy, but exclusively

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von der Heide, Eva, Sebastian Vosberg, Martin Neumann, et al. "Molecular Alterations in Bone Marrow Mesenchymal Stroma Cells of AML Patients." Blood 124, no. 21 (2014): 699. http://dx.doi.org/10.1182/blood.v124.21.699.699.

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Abstract It is increasingly recognized that the tumor microenvironment plays a pivotal role in cancer initiation and progression. In mouse models it was shown that a genetically altered bone marrow (BM) micro milieu was sufficient to induce leukemia (Raaijmakers, Nature 2010); however, the pathogenic role and contribution of the BM stroma in leukemia initiation and during disease progression warrants further investigation. To address this, we have performed gene expression, methylation, RNAseq, whole exome sequencing (WES) in BM mesenchymal stroma cells (BM-MSC) and leukemic cells from AML pat

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Bajo, Ignacio, and Saïd Benayadi. "Quadratic Lie algebras with 2-plectic structures." Journal of Geometry and Physics, August 2023, 104958. http://dx.doi.org/10.1016/j.geomphys.2023.104958.

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Sevestre, Gabriel, and Tilmann Wurzbacher. "On the Prequantisation Map for 2-Plectic Manifolds." Mathematical Physics, Analysis and Geometry 24, no. 2 (2021). http://dx.doi.org/10.1007/s11040-021-09391-5.

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Mizuta, Kana, Takuma Matsubara, Akino Goto, et al. "Plectin promotes tumor formation by B16 mouse melanoma cells via regulation of Rous sarcoma oncogene activity." BMC Cancer 22, no. 1 (2022). http://dx.doi.org/10.1186/s12885-022-10033-4.

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Abstract Background Melanoma is a malignant tumor characterized by high proliferation and aggressive metastasis. To address the molecular mechanisms of the proto-oncogene, Rous sarcoma oncogene (Src), which is highly activated and promotes cell proliferation, migration, adhesion, and metastasis in melanoma. Plectin, a cytoskeletal protein, has recently been identified as a Src-binding protein that regulates Src activity in osteoclasts. Plectin is a candidate biomarker of certain tumors because of its high expression and the target of anti-tumor reagents such as ruthenium pyridinecarbothioamide

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Kor‐anantakul, Phawin, Huey‐Ling Chen, Ya‐Hui Chen, et al. "Novel PLEC variants associated with infantile cholestasis." Clinical Genetics, August 21, 2024. http://dx.doi.org/10.1111/cge.14611.

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AbstractPlectin is a cytoskeletal linker of intermediate filaments, encoded by the PLEC gene. Recently, plectin mutations have been identified in a pair of siblings with progressive familial intrahepatic cholestasis. Here, we reported two unrelated infants with plectinopathy causing cholestatic jaundice with novel variants in the PLEC gene. Trio exome sequencing identified compound heterozygous variants in the PLEC gene for each patient: c.71‐11768C>T and c.4331G>T (p.Arg1444Leu) in Patient 1, and c.592C>T (p.Arg198Trp) and c.4322G>A (p.Arg1441His) in Patient 2. Immunofluorescence

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Song, Byeong Geun, Wooil Kwon, Hyemin Kim, et al. "Detection of Circulating Tumor Cells in Resectable Pancreatic Ductal Adenocarcinoma: A Prospective Evaluation as a Prognostic Marker." Frontiers in Oncology 10 (February 18, 2021). http://dx.doi.org/10.3389/fonc.2020.616440.

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Circulating tumor cells (CTCs) are useful biomarkers of many solid tumors, but are infrequently detected in early stage pancreatic ductal adenocarcinomas (PDACs). The first drainage of pancreatic venous blood flow come to portal vein and pass through the liver, and they finally go out for peripheral blood. We thought that comparing CTCs from portal vein and peripheral blood could enable us to understand the clinical meaning of CTCs from each different site in PDACs. Therefore, we aimed to determine 1) whether CTCs could be reliably identified in early stages (operable) of PDACs, 2) if there ar

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