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Relevant bibliographies by topics / 2-propylpentanoic acid

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Academic literature on the topic '2-propylpentanoic acid'

Author: Grafiati

Published: 5 June 2025

Last updated: 1 August 2025

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Journal articles on the topic "2-propylpentanoic acid"

1

Malygin, A. S., N. S. Popov, M. A. Demidova, and M. N. Kudrayshova. "Chromatography-tandem MASS spectrometry (HPLC-MS/MS) for the detection of valproic acid and its metabolites in blood plasma." Epilepsia and paroxyzmal conditions 10, no. 2 (2018): 35–42. http://dx.doi.org/10.17749/2077-8333.2018.10.2.035-042.

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Aim: to adapt the HPLC-MS/MS technique to determining valproic acid and its metabolites in blood plasma for drug therapy monitoring.Materials and Methods: The chromatographic assay was run using an Agilent 1260 Infinity II chromatograph with a Phenomenex synergi Fusion analytical column 4 μm-C18 2×50 mm. The mobile phase consisted of 0.1% ammonium acetate in distilled water and 0.1% ammonium acetate in methanol (10:90 v/v, 0.5 ml/min). The multiple ions monitoring (MIM) mode was used for mass- spectrometric detection of valproic acid at m/z = 143.1, with the negative ion mode. The method was f

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2

Gopaul, V. S., W. Tang, K. Farrell, and F. S. Abbott. "Amino Acid Conjugates: Metabolites of 2-Propylpentanoic Acid (Valproic Acid) in Epileptic Patients." Drug Metabolism and Disposition 31, no. 1 (2003): 114–21. http://dx.doi.org/10.1124/dmd.31.1.114.

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3

Malygin, Alexandr S., and Victor V. Yasnetsov. "Design and evaluation of pharmacological properties of a new 1,3,4-thiadiazolylamide derivative of 2-propylpentanoic acid." Research Results in Pharmacology 7, no. 4 (2021): 89–98. http://dx.doi.org/10.3897/rrpharmacology.7.70179.

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Introduction: The use of the pharmacophoric approach is a promising direction for modifying the chemical structure of 2-propylpentanoic (valproic) acid in order to obtain new drugs. Materials and methods: In the experiments on mice, acute toxicity, neurotoxicity, antiepileptic activity and analgesic effect of N-(5-ethyl-1,3,4-thiadiazol-2-yl)-2-propylpentanamide (valprazolamide) were evaluated. LD50 was determined by probit analysis. Neurotoxicity was determined in a rotarod test and a bar test in mice. The effects of valprazolamide on the exploratory behavior of mice in open field test and in

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4

Valenta, Vladimír, Zdeněk Vejdělek, Karel Šindelář, and Miroslav Protiva. "Potential anticonvulsants: Some derivatives and analogues of 2-propylpentanoic acid." Collection of Czechoslovak Chemical Communications 55, no. 4 (1990): 1067–76. http://dx.doi.org/10.1135/cccc19901067.

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Reaction of 2-(ethoxycarbonylamino)ethanol with 2-propylpentanoyl chloride gave the ester III. N-(4-Piperidinyl)-2-propylpentanamide (V) was prepared via the 1-benzyl-4-piperidinyl derivative IV and was acylated with ethanesulfonyl chloride and 2-propylpentanoyl chloride to give the amides VI and VII. Malonic ester syntheses afforded diethyl 2-ethyl- and 2-propyl-2-(2-(methylthio)ethyl)malonate VIII and XIII which were hydrolyzed and decarboxylated to the acids X and XV which, in turn, were transformed to the amides XII and XVII. 3-Thiapentanenitrile was alkylated with propyl bromide to the ni

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5

Malygin, Alexandr S., and Victor V. Yasnetsov. "Design and evaluation of pharmacological properties of a new 1,3,4-thiadiazolylamide derivative of 2-propylpentanoic acid." Research Results in Pharmacology 7, no. (4) (2021): 89–98. https://doi.org/10.3897/rrpharmacology.7.70179.

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Introduction: The use of the pharmacophoric approach is a promising direction for modifying the chemical structure of 2-propylpentanoic (valproic) acid in order to obtain new drugs. Materials and methods: In the experiments on mice, acute toxicity, neurotoxicity, antiepileptic activity and analgesic effect of N-(5-ethyl-1,3,4-thiadiazol-2-yl)-2-propylpentanamide (valprazolamide) were evaluated. LD<sub>50</sub> was determined by probit analysis. Neurotoxicity was determined in a rotarod test and a bar test in mice. The effects of valprazolamide on the exploratory behavior of mice in open field

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6

Pucci, Vincenzo, Roberto Mandrioli, and Maria A. Raggi. "Determination of valproic acid (2-propylpentanoic acid) in human plasma by capillary electrophoresis with indirect UV detection." ELECTROPHORESIS 24, no. 1213 (2003): 2076–83. http://dx.doi.org/10.1002/elps.200305405.

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7

Giraldo, Liliana, and Juan Carlos Moreno-Piraján. "Calorimetric Study of Mesoporous SBA-15 Modified for Controlled Valproic Acid Delivery." Journal of Chemistry 2013 (2013): 1–11. http://dx.doi.org/10.1155/2013/267464.

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SBA-15 ordered mesoporous silica functionalized with (3-aminopropyl)triethoxysilane (APTES) was used as the carrier for anticonvulsant drug 2-propylpentanoic acid (valproic acid). The surface of SBA-15 containing free silanol groups was modified with 3-aminopropyltriethoxysilane via postsynthetic reaction. Functionalization of the carrier with basic aminopropyl groups resulted in an ionic interaction with acidic valproic acid. The samples of carriers and carrier-drug complexes were characterized by elemental analysis, N2adsorption, FTIR, and UV spectroscopy. The adsorption of valproic acid on

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8

Wawruszak, Anna, Marta Halasa, Estera Okon, Wirginia Kukula-Koch, and Andrzej Stepulak. "Valproic Acid and Breast Cancer: State of the Art in 2021." Cancers 13, no. 14 (2021): 3409. http://dx.doi.org/10.3390/cancers13143409.

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Valproic acid (2-propylpentanoic acid, VPA) is a short-chain fatty acid, a member of the group of histone deacetylase inhibitors (HDIs). VPA has been successfully used in the treatment of epilepsy, bipolar disorders, and schizophrenia for over 50 years. Numerous in vitro and in vivo pre-clinical studies suggest that this well-known anticonvulsant drug significantly inhibits cancer cell proliferation by modulating multiple signaling pathways. Breast cancer (BC) is the most common malignancy affecting women worldwide. Despite significant progress in the treatment of BC, serious adverse effects,

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Mao, L. F., D. S. Millington, and H. Schulz. "Formation of a free acyl adenylate during the activation of 2-propylpentanoic acid. Valproyl-AMP: a novel cellular metabolite of valproic acid." Journal of Biological Chemistry 267, no. 5 (1992): 3143–46. http://dx.doi.org/10.1016/s0021-9258(19)50706-2.

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Akshaya, Narayanan, Prakash Prasith, Balakrishnan Abinaya, Badrinath Ashwin, S. V. Chandran, and Nagarajan Selvamurugan. "Valproic acid, A Potential Inducer of Osteogenesis in Mouse Mesenchymal Stem Cells." Current Molecular Pharmacology 14, no. 1 (2020): 27–35. http://dx.doi.org/10.2174/1874467213666200713102410.

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Background: Recent reports have unveiled the potential of flavonoids to enhance bone formation and assuage bone resorption due to their involvement in cell signaling pathways. They also act as an effective alternative to circumvent the disadvantages associated with existing treatment methods, which has increased their scope in orthopedic research. Valproic acid (VA, 2-propylpentanoic acid) is one such flavonoid, obtained from an herbaceous plant, used in the treatment of epilepsy and various types of seizures. Objective: In this study, the role of VA in osteogenesis and the molecular mechanism

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Book chapters on the topic "2-propylpentanoic acid"

1

Pardasani, R. T., and P. Pardasani. "Magnetic properties of dinuclear nickel(II) with 2-propylpentanoic acid." In Magnetic Properties of Paramagnetic Compounds. Springer Berlin Heidelberg, 2017. http://dx.doi.org/10.1007/978-3-662-54234-7_390.

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2

"2-Propylpentanoic Acid." In Encyclopedia of Cancer. Springer Berlin Heidelberg, 2016. http://dx.doi.org/10.1007/978-3-662-46875-3_100039.

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"2-Propylpentanoic Acid." In Encyclopedia of Cancer. Springer Berlin Heidelberg, 2011. http://dx.doi.org/10.1007/978-3-642-16483-5_4775.

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