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Journal articles on the topic '2-propylpentanoic acid'

Author: Grafiati

Published: 5 June 2025

Last updated: 1 August 2025

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1

Malygin, A. S., N. S. Popov, M. A. Demidova, and M. N. Kudrayshova. "Chromatography-tandem MASS spectrometry (HPLC-MS/MS) for the detection of valproic acid and its metabolites in blood plasma." Epilepsia and paroxyzmal conditions 10, no. 2 (2018): 35–42. http://dx.doi.org/10.17749/2077-8333.2018.10.2.035-042.

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Aim: to adapt the HPLC-MS/MS technique to determining valproic acid and its metabolites in blood plasma for drug therapy monitoring.Materials and Methods: The chromatographic assay was run using an Agilent 1260 Infinity II chromatograph with a Phenomenex synergi Fusion analytical column 4 μm-C18 2×50 mm. The mobile phase consisted of 0.1% ammonium acetate in distilled water and 0.1% ammonium acetate in methanol (10:90 v/v, 0.5 ml/min). The multiple ions monitoring (MIM) mode was used for mass- spectrometric detection of valproic acid at m/z = 143.1, with the negative ion mode. The method was f

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2

Gopaul, V. S., W. Tang, K. Farrell, and F. S. Abbott. "Amino Acid Conjugates: Metabolites of 2-Propylpentanoic Acid (Valproic Acid) in Epileptic Patients." Drug Metabolism and Disposition 31, no. 1 (2003): 114–21. http://dx.doi.org/10.1124/dmd.31.1.114.

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3

Malygin, Alexandr S., and Victor V. Yasnetsov. "Design and evaluation of pharmacological properties of a new 1,3,4-thiadiazolylamide derivative of 2-propylpentanoic acid." Research Results in Pharmacology 7, no. 4 (2021): 89–98. http://dx.doi.org/10.3897/rrpharmacology.7.70179.

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Introduction: The use of the pharmacophoric approach is a promising direction for modifying the chemical structure of 2-propylpentanoic (valproic) acid in order to obtain new drugs. Materials and methods: In the experiments on mice, acute toxicity, neurotoxicity, antiepileptic activity and analgesic effect of N-(5-ethyl-1,3,4-thiadiazol-2-yl)-2-propylpentanamide (valprazolamide) were evaluated. LD50 was determined by probit analysis. Neurotoxicity was determined in a rotarod test and a bar test in mice. The effects of valprazolamide on the exploratory behavior of mice in open field test and in

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4

Valenta, Vladimír, Zdeněk Vejdělek, Karel Šindelář, and Miroslav Protiva. "Potential anticonvulsants: Some derivatives and analogues of 2-propylpentanoic acid." Collection of Czechoslovak Chemical Communications 55, no. 4 (1990): 1067–76. http://dx.doi.org/10.1135/cccc19901067.

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Reaction of 2-(ethoxycarbonylamino)ethanol with 2-propylpentanoyl chloride gave the ester III. N-(4-Piperidinyl)-2-propylpentanamide (V) was prepared via the 1-benzyl-4-piperidinyl derivative IV and was acylated with ethanesulfonyl chloride and 2-propylpentanoyl chloride to give the amides VI and VII. Malonic ester syntheses afforded diethyl 2-ethyl- and 2-propyl-2-(2-(methylthio)ethyl)malonate VIII and XIII which were hydrolyzed and decarboxylated to the acids X and XV which, in turn, were transformed to the amides XII and XVII. 3-Thiapentanenitrile was alkylated with propyl bromide to the ni

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5

Malygin, Alexandr S., and Victor V. Yasnetsov. "Design and evaluation of pharmacological properties of a new 1,3,4-thiadiazolylamide derivative of 2-propylpentanoic acid." Research Results in Pharmacology 7, no. (4) (2021): 89–98. https://doi.org/10.3897/rrpharmacology.7.70179.

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Introduction: The use of the pharmacophoric approach is a promising direction for modifying the chemical structure of 2-propylpentanoic (valproic) acid in order to obtain new drugs. Materials and methods: In the experiments on mice, acute toxicity, neurotoxicity, antiepileptic activity and analgesic effect of N-(5-ethyl-1,3,4-thiadiazol-2-yl)-2-propylpentanamide (valprazolamide) were evaluated. LD<sub>50</sub> was determined by probit analysis. Neurotoxicity was determined in a rotarod test and a bar test in mice. The effects of valprazolamide on the exploratory behavior of mice in open field

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6

Pucci, Vincenzo, Roberto Mandrioli, and Maria A. Raggi. "Determination of valproic acid (2-propylpentanoic acid) in human plasma by capillary electrophoresis with indirect UV detection." ELECTROPHORESIS 24, no. 1213 (2003): 2076–83. http://dx.doi.org/10.1002/elps.200305405.

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7

Giraldo, Liliana, and Juan Carlos Moreno-Piraján. "Calorimetric Study of Mesoporous SBA-15 Modified for Controlled Valproic Acid Delivery." Journal of Chemistry 2013 (2013): 1–11. http://dx.doi.org/10.1155/2013/267464.

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SBA-15 ordered mesoporous silica functionalized with (3-aminopropyl)triethoxysilane (APTES) was used as the carrier for anticonvulsant drug 2-propylpentanoic acid (valproic acid). The surface of SBA-15 containing free silanol groups was modified with 3-aminopropyltriethoxysilane via postsynthetic reaction. Functionalization of the carrier with basic aminopropyl groups resulted in an ionic interaction with acidic valproic acid. The samples of carriers and carrier-drug complexes were characterized by elemental analysis, N2adsorption, FTIR, and UV spectroscopy. The adsorption of valproic acid on

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8

Wawruszak, Anna, Marta Halasa, Estera Okon, Wirginia Kukula-Koch, and Andrzej Stepulak. "Valproic Acid and Breast Cancer: State of the Art in 2021." Cancers 13, no. 14 (2021): 3409. http://dx.doi.org/10.3390/cancers13143409.

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Valproic acid (2-propylpentanoic acid, VPA) is a short-chain fatty acid, a member of the group of histone deacetylase inhibitors (HDIs). VPA has been successfully used in the treatment of epilepsy, bipolar disorders, and schizophrenia for over 50 years. Numerous in vitro and in vivo pre-clinical studies suggest that this well-known anticonvulsant drug significantly inhibits cancer cell proliferation by modulating multiple signaling pathways. Breast cancer (BC) is the most common malignancy affecting women worldwide. Despite significant progress in the treatment of BC, serious adverse effects,

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9

Mao, L. F., D. S. Millington, and H. Schulz. "Formation of a free acyl adenylate during the activation of 2-propylpentanoic acid. Valproyl-AMP: a novel cellular metabolite of valproic acid." Journal of Biological Chemistry 267, no. 5 (1992): 3143–46. http://dx.doi.org/10.1016/s0021-9258(19)50706-2.

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10

Akshaya, Narayanan, Prakash Prasith, Balakrishnan Abinaya, Badrinath Ashwin, S. V. Chandran, and Nagarajan Selvamurugan. "Valproic acid, A Potential Inducer of Osteogenesis in Mouse Mesenchymal Stem Cells." Current Molecular Pharmacology 14, no. 1 (2020): 27–35. http://dx.doi.org/10.2174/1874467213666200713102410.

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Background: Recent reports have unveiled the potential of flavonoids to enhance bone formation and assuage bone resorption due to their involvement in cell signaling pathways. They also act as an effective alternative to circumvent the disadvantages associated with existing treatment methods, which has increased their scope in orthopedic research. Valproic acid (VA, 2-propylpentanoic acid) is one such flavonoid, obtained from an herbaceous plant, used in the treatment of epilepsy and various types of seizures. Objective: In this study, the role of VA in osteogenesis and the molecular mechanism

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11

SILVA, Margarida F. B., Jos P. N. RUITER, Henk OVERMARS та ін. "Complete β-oxidation of valproate: cleavage of 3-oxovalproyl-CoA by a mitochondrial 3-oxoacyl-CoA thiolase". Biochemical Journal 362, № 3 (2002): 755–60. http://dx.doi.org/10.1042/bj3620755.

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The β-oxidation of valproic acid (VPA; 2-n-propylpentanoic acid) was investigated in vitro in intact rat liver mitochondria incubated with 3H-labelled VPA. The metabolism of [4,5-3H2]VPA and [2-3H]VPA was studied by analysing the different acyl-CoA intermediates formed by reverse-phase HPLC with radiochemical detection. Valproyl-CoA, Δ2(E)-valproyl-CoA,3-hydroxyvalproyl-CoA and 3-oxovalproyl-CoA (labelled and non-labelled) were determined using continuous on-line radiochemical and UV detection. The formation of these intermediates was investigated using the two tritiated precursors in respirat

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12

Belrose, Gildas, Antoine Gross, Stéphane Olindo, et al. "Effects of valproate on Tax and HBZ expression in HTLV-1 and HAM/TSP T lymphocytes." Blood 118, no. 9 (2011): 2483–91. http://dx.doi.org/10.1182/blood-2010-11-321364.

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AbstractA determinant of human T-lymphotropic virus-1 (HTLV-1)–associated myelopathy/tropical spastic paraparesis (HAM/TSP) development is the HTLV-1–infected cell burden. Viral proteins Tax and HBZ, encoded by the sense and antisense strands of the pX region, respectively, play key roles in HTLV-1 persistence. Tax drives CD4+-T cell clonal expansion and is the immunodominant viral antigen recognized by the immune response. Valproate (2-n-propylpentanoic acid, VPA), a histone deacetylase inhibitor, was thought to trigger Tax expression, thereby exposing the latent HTLV-1 reservoir to immune de

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13

Sandilya, Vijay Krishna, Vikas Ghai, Kamal Sharma, Kamal Kant Singh Abbi, and Elliot E. Epner. "Combination HDACi and mTOR inhibitor therapy in poor-risk de novo and refractory elderly patients with AML." Journal of Clinical Oncology 31, no. 15_suppl (2013): e18012-e18012. http://dx.doi.org/10.1200/jco.2013.31.15_suppl.e18012.

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e18012 Background: Valproic acid (VPA, 2-propylpentanoic acid) is a histone deacetylase inhibitors (HDACi), which has in vitro activity against Acute Myeloid Leukemia (AML) blasts. HDACi produce epigenetic modifications, and may have antineoplastic effects in AML by activating transcriptional silenced genes. The mammalian target of rapamycin (mTOR) pathways constitutive activation has been involved in the pathogenesis of various cancers, including AML. We present a series of two cases of poor risk de novo and refractory elderly AML patients treated with a combination of HDACi VPA and mTOR inhi

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14

Gabano, Elisabetta, Marzia Gariboldi, Emanuela Marras, Francesca Barbato, and Mauro Ravera. "Platinum(IV) combo prodrugs containing cyclohexane-1R,2R-diamine, valproic acid, and perillic acid as a multiaction chemotherapeutic platform for colon cancer." Dalton Transactions, 2023. http://dx.doi.org/10.1039/d3dt01876h.

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The complex [PtCl2(cyclohexane-1R,2R-diamine)] has been combined in a Pt(IV) molecule with two different bioactive molecules (i.e., the histone deacetylase inhibitor 2-propylpentanoic acid or valproic acid, VPA, and the potential antimetastatic...

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15

Farsa, Oldřich. "Synthesis of valproic acid for medicinal chemistry practical classes." Chemistry Teacher International, May 28, 2025. https://doi.org/10.1515/cti-2025-0028.

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Abstract Medicinal (or also Pharmaceutical) Chemistry practical classes are intended to familiarize students who have already passed Inorganic and Organic Chemistry Courses in the first or the second year of a Faculty of Pharmacy with real syntheses of medicines that are used in the practice. The selection of practical tasks is limited by the time reserved for each practical lesson in which at least one step of a multi-step synthesis must be done. This fact pushes us to optimize individual synthesis steps to shorten them as much as possible, but with acceptable yields. Valproic acid, 2-propylp

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16

Wu, Shengde, Corie Ellison, Jorge Naciff, et al. "Structure Activity Relationship Read Across and Transcriptomics for Branched Carboxylic Acids." Toxicological Sciences, December 30, 2022. http://dx.doi.org/10.1093/toxsci/kfac139.

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Abstract The purpose of this study was to use chemical similarity evaluations, transcriptional profiling, in vitro toxicokinetic data and physiologically based pharmacokinetic (PBPK) models to support read across for a series of branched carboxylic acids using valproic acid (VPA), a known developmental toxicant, as a comparator. The chemicals included 2-propylpentanoic acid (VPA), 2-ethylbutanoic acid (EBA), 2-ethylhexanoic acid (EHA), 2-methylnonanoic acid (MNA), 2-hexyldecanoic acid (HDA), 2-propylnonanoic acid (PNA), dipentyl acetic acid (DPA) or 2-pentylheptanoic acid (PHA), octanoic acid

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17

Hamaidia, Malik, Pierre-Yves Barez, Alexandre Carpentier, et al. "From Valeriana officinalis to cancer therapy: the success of a bio-sourced compound." BASE, 2016, 314–20. http://dx.doi.org/10.25518/1780-4507.12739.

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Introduction. Over the centuries, bio-sourced compounds isolated from plants, insects and microorganisms have been a potent source of drugs for the treatment of human diseases. Literature. Bio-sourced extracts offer a wide diversity of compounds with a large number of potentially beneficial effects in humans. Serendipity has frequently played a key role in the discovery of new medicines. The canonical discovery of penicillin required both chance and a prepared mind to understand and exploit its potential for the treatment of human infections. Nowadays, most anti-cancer drugs currently in clini

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18

A. Haroun, Ahmed, Ragab A. Masoud, and Ali H. M. Osman. "Preparation and Applicationof Immobilized Valproic Acid Xerogel as Delivery System." Journal of Sustainable Materials Processing and Management 4, no. 2 (2024). http://dx.doi.org/10.30880/jsmpm.2024.04.02.002.

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The objective of this study is to conduct the preparation and characterization of a xerogel through the co-gelation process involving tetraethyl orthosilicate (TEOS) and 2-propylpentanoic acid (Valproic acid, VA). The characterization of the resulting xerogel utilized techniques such as infrared spectroscopy (FT-IR), X-ray diffraction (XRD), as well as scanning and transmitting electron microscopes (SEM and TEM). Furthermore, the in vitro release of VA and the kinetics ofits release were investigatedemploying various mathematical models (zero-order, first-order, and Higuchi) in a phosphate buf

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19

Saiz, Maria Laura, Marta L. DeDiego, Darío López-García, et al. "Epigenetic targeting of the ACE2 and NRP1 viral receptors limits SARS-CoV-2 infectivity." Clinical Epigenetics 13, no. 1 (2021). http://dx.doi.org/10.1186/s13148-021-01168-5.

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Abstract Background SARS-CoV-2 uses the angiotensin-converting enzyme 2 (ACE2) and neuropilin-1 (NRP1) receptors for entry into cells, and the serine protease TMPRSS2 for S protein priming. Inhibition of protease activity or the engagement with ACE2 and NRP1 receptors has been shown to be an effective strategy for blocking infectivity and viral spreading. Valproic acid (VPA; 2-propylpentanoic acid) is an epigenetic drug approved for clinical use. It produces potent antiviral and anti-inflammatory effects through its function as a histone deacetylase (HDAC) inhibitor. Here, we propose VPA as a

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20

Gao, Xue, Salman Zeb, Yuan-Yuan He, et al. "Valproic Acid Inhibits Glial Scar Formation after Ischemic Stroke." Pharmacology, March 22, 2022, 1–18. http://dx.doi.org/10.1159/000514951.

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<b><i>Introduction:</i></b> Cerebral ischemia induces reactive proliferation of astrocytes (astrogliosis) and glial scar formation. As a physical and biochemical barrier, the glial scar not only hinders spontaneous axonal regeneration and neuronal repair but also deteriorates the neuroinflammation in the recovery phase of ischemic stroke. <b><i>Objectives:</i></b> Previous studies have shown the neuroprotective effects of the valproic acid (2-n-propylpentanoic acid, VPA) against ischemic stroke, but its effects on the ischemia-induced formation o

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