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Dissertations / Theses on the topic '2-pyrazoles'

Author: Grafiati

Published: 4 June 2021

Last updated: 14 February 2022

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1

Grosse, Sandrine. "Imidazo[1, 2-b]pyrazoles, imidazo[1, 2-a]imidazoles : synthèse, fonctionnalisation et évaluation biologique." Thesis, Orléans, 2013. http://www.theses.fr/2013ORLE2056.

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Les imidazo[1,2-b]pyrazoles tout comme les imidazo[1,2-a]imidazoles sont des entités présentant diverses applications intéressantes notamment dans le domaine pharmacologique. Cependant, malgré ce potentiel, ces structures hétérobicycliques ont été, jusqu’à ce jour, relativement peu étudiées tant au niveau de leur préparation que de leur fonctionnalisation. De ce fait, ces travaux de thèse ont pour objet la mise au point de nouvelles voies d’accès à ces systèmes bicycliques et ce, au départ de substrats facilement accessibles. Des stratégies de fonctionnalisation de ces charpentes moléculaires

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2

Desalegn, Nebiyou. "Kinetic Studies Of The Thermolysis Of 3-Halogenated-4,5-Dihydro-3h-Pyrazoles." Digital Archive @ GSU, 2005. http://digitalarchive.gsu.edu/chemistry_theses/1.

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3-Chloro-4,4,5-trimethyl-3,5-diphenyl-4,5-dihydro-3H-pyrazole (3b) and 3-bromo-4,4,5-trimethyl-3,5-diphenyl-4,5-dihydro-3H-pyrazole (3c) were prepared for the thermolysis project. The thermal decompositions of 3b and 3c were monitored using 1H NMR spectroscopy. Plots of ln (% starting material) vs. time (sec) were linear for at least two half lives and the first order rate constants were determined over at least a 30o temperature range. The relative reactivity was found to be 3c > 3b. The activation parameters determined for the thermal decomposition of the pyrazoline at 150oC were found to be

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3

Verma, Astha. "Small Core Heterocyclic Carbamates and Carboxamides: Resistance-breaking Acetylcholinesterase Inhibitors Targeting the Malaria Mosquito, Anopheles gambiae." Diss., Virginia Tech, 2014. http://hdl.handle.net/10919/64294.

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Malaria is one of the deadliest diseases known to mankind. In 2010, 219 million cases were reported, and 666,000 deaths were attributed to this disease. In the past, pyrethroid-treated mosquito nets have shown efficacy in reducing malaria transmission in many malaria endemic regions. However, an upsurge in the mosquito population that is resistant to pyrethroids threatens to compromise the efficacy of pyrethroid-treated bed nets. In an effort to develop another class of insecticide with a different mode of action, we have explored three classes of five membered heterocyclic carbamates (isoxazo

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4

Moreira, Dayse das Neves. "Síntese de pirazóis e desenvolvimento de novos líquidos iônicos derivados de componentes farmacologicamente ativos." Universidade Federal de Santa Maria, 2011. http://repositorio.ufsm.br/handle/1/4214.

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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior<br>The synthesis of two series of N-substituted pyrazoles from the cyclocondensation reaction of β-enaminones ([R1C(O)C(R2)=CHN(Me2)], where R1 = Me, C6H5, 3-MeOC6H4, 4-Me-C6H4, 4-MeO-C6H4, 4-F-C6H4, 4-Cl-C6H4, 4-Br-C6H4, 4-O2N-C6H4, fur-2-il, thien-2-il; R2 = H, 2-MeO-C6H4) and 2-hydroxyethylhydrazine or 1-pentafluorophenylhydrazine was demonstrated. The reactions were performed in five ionic liquids ([BMIM][BF4], [BMIM][Br], [BMIM][OH], [HMIM][HSO4] e [BPy][BF4]) with different physical and chemical properties to establish the

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5

Truong, Phong Minh. "Hexa-aryl/alkylsubstituted Cyclopropanes." Digital Archive @ GSU, 2006. http://digitalarchive.gsu.edu/chemistry_theses/2.

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A series of penta-aryl/alkyl-1-(toluene-4-sulfonyl)-4,5-dihydro-1H-pyrazole 5a-c was synthesized by addition of methyllithium or phenylllithium followed by trapping the nitrogen anion intermediate with tosyl-fluoride to cyclic azines 2a,b. Addition of methyllithium or phenyllithium to 5a-c generated a series of hexa-aryl/alkylsubstituted-4,5-dihydro-3H-pyrazoles 6a-c. Neat thermolysis of hexa-aryl/alkylsubstituted-4,5-dihydro-3H-pyrazoles 6a-c at 200◦C produced hexa-aryl/alkylsubstituted cyclopropanes 7a-c in high yield.

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6

Motson, Graham Robert. "Coordination chemistry of 3-(2'-pyridyl) pyrazole derivative ligands." Thesis, University of Bristol, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.391153.

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7

Böhnisch, Torben. "C₂-Symmetric Pyrazole-Bridged Ligands and Their Application in Asymmetric Transition-Metal Catalysis." Doctoral thesis, Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2015. http://hdl.handle.net/11858/00-1735-0000-0028-876A-6.

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8

Wong, Joanne. "Designing New Heterometallic [2 x 2] Grids using Pyrazolate-bridged Ligands." Doctoral thesis, Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2019. http://hdl.handle.net/21.11130/00-1735-0000-0005-1323-E.

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9

Sens, Llorca Cristina. "New mono- and dinuclear ruthenium complexes containing the 3,5-bis(2-pyridyl)pyrazole ligand. Synthesis, characterization and applications." Doctoral thesis, Universitat de Girona, 2005. http://hdl.handle.net/10803/8034.

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Se han sintetizado dos nuevos complejos mononucleares de Ru, con formula [RuCl2(Hbpp)(dmso)2], a partir de la reacción entre [RuCl2(dmso)4] y Hbpp (3,5-bis(2-piridil)pirazola). El hecho que sólo tres de los seis posibles estereoisómeros se obtengan a partir de esta reacción, se ha racionalizado en base a factores estructurales y electrónicos. Estos complejos se han caracterizado de forma estructural, espectroscópica y electroquímica. En acetonitrilo en medio básico, el isómero trans,cis-[RuCl2(Hbpp)(dmso)2] da lugar a procesos de isomerización de enlace de un ligando dmso cuando el Ru(II) se o

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10

Meunier, Andreas. "Cyclooxygenase-2 inhibitors and knee prosthesis surgery." Doctoral thesis, Linköping : Department of Clinical and Experimental Medicine, Linköping University, 2008. http://www.bibl.liu.se/liupubl/disp/disp2008/med1077s.pdf.

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11

Kuhn, Bruna Pereira. "Síntese de 1,1,1-trifluoro-4-metoxi-3-alquen-2-onas funcionalizadas e 1,2-azóis derivados." Universidade Federal de Santa Maria, 2014. http://repositorio.ufsm.br/handle/1/10587.

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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior<br>This work describes the application of the method of trifluoroacetic anhydride acetal acylation to four new functionalized ketones: 6-methyl-5-hepten-2-one, 4-phenyl-4- oxobutanoic acid (3-benzoylpropionic acid), 5-bromo-2-acetylthiophene and 2- propionylthiophene. The acylated products were obtained as β-trifluoromethyl ketones alkoxyvinyl and β-diketones. The product derived from 2-propionylthiophene was obtained as dihydrate, 3,3-dihydroxy-4,4,4-trifluoro-1-(2-thienyl)-2-butanone, its structure was confirmed by X-ray diffraction

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12

Machado, Pablo. "5-Hidróxi-4,5-diidro-1H-1-(2-hidroxibenzoil)pirazóis: Planejamento, Síntese e Analgesia." Universidade Federal de Santa Maria, 2007. http://repositorio.ufsm.br/handle/1/10638.

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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior<br>An efficient method to obtain six 4-alkoxy-2-oxo-but-3-enoic acid ethyl esters [EtO2CC(O)C(R2)=C(R1)OR, where R1/R2/R = Me/H/Me (2a), Ph/H/Me (2b), 4-MeC6H4/H/Me (2c), 4-BrC6H4/H/Me (2d), 4-FC6H4/H/Me (2e), H/Me/Et (2f)] from acylation of enol ethers or acetals with ethyl oxalyl chloride is reported. The cyclocondensation reaction of these substrates and their trifluormethylated analogues (5a-f) [CF3C(O)C(R2)=C(OR)R1] with salicylic hydrazide furnished a series of ethyl 5-hydroxy-1-(2-hydroxybenzoyl)-4,5-dihydro-1H-pyrazole-5-carbo

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13

Rosales, Pauline Fagundes. "Bi-heterociclos a partir do Ácido Levulínico: Síntese de 5-[(5-(trifluormetil)-5-hidroxi-(3-substituido)-4,5-diidro-1H-pirazol-1-il)-1-propan-1-ona-3-il]-2-metil-7-trifluormetil)pirazolo[1,5-a]pirimidinas." Universidade Federal de Santa Maria, 2013. http://repositorio.ufsm.br/handle/1/10535.

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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior<br>An efficient method to obtain 2-methyl-5-(methylpropanoate-3-yl)-7-trifluoromethylpyrazolo[1,5-a]pyrimidine 2 from the reaction of compound methyl 7,7,7-trifluoro-4-methoxy-6-oxo-heptenoate with 3-amino-5-methyl-1H-pyrazol. This compound 2 brought to reaction with hydrazine monohydrate to obtain 2-methyl-7-trifluoromethylpyrazolo[1,5-a]pyrimidine-5-propanehydrazine 3 and after were later brought to cyclocondensation reaction with a series of β-alkoxyvinyltrifluoromethyl ketones giving the series of news bi-heterocyclic 5-[(5-(trifl

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14

Piovesan, Luciana Almeida. "Síntese de novos heterociclos a partir do ácido levulínico." Universidade Federal de Santa Maria, 2009. http://repositorio.ufsm.br/handle/1/4233.

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Conselho Nacional de Desenvolvimento Científico e Tecnológico<br>The synthesis of new compounds alkyl 3-azolyl propanoate e alkyl 3-azolyl propanoic acid structurally analogues to gamma-aminobutiric acid (GABA) is reported. One more time using the acetal acylation method, now the acetal derivative of 4-oxopentanoic acid (levulinic acid), the methyl 4,4- dimethoxypentanoate, were obtained the precursors methyl 7,7,7-trifluoro[chloro]-4- methoxy-6-oxo-heptenoates, 1,3-dieletrophilic precursor with alcanoate substituent. Are presented efficient and regioespecific synthetic routes from reactions o

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15

Fouqué, Didier. "Préparation de phosphonates alpha-hétérocycliques à partir de phosphonates difonctionnels. Utilisation en synthèse." Rouen, 1990. http://www.theses.fr/1990ROUES037.

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Une nouvelle méthode de synthèse de phosphonates bêta, delta-dicarbonylés via les dianions des 2-oxoalkylphosphonates a été développée. Elle permet d'accéder en une seule étape, d'une façon simple et efficace aux bêta-cétophosphonates delta-esters, -cétones ou -aldéhydes diversement substitués par des groupes alkyles. Les phosphonates bêta, gamma et gamma, gamma-difonctionnels ont été synthétisés par des méthodes plus traditionnelles associant des réactions thermiques et carbanioniques. Ces phosphonates diélectrophiles ont été condensés avec des bis-nucléophiles pour obtenir des phosphonates a

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16

Kuleshova, Olena. "2-azahetaryl-3-enaminonitriles cycliques pour la synthèse d'azahétérocycles fonctionnalisés, la complexation de métaux et la conception de sondes optiques." Thesis, Toulouse 3, 2018. http://www.theses.fr/2018TOU30127/document.

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Les recherches effectuées au cours de ce travail de thèse sont centrées sur les dérivés cycliques de type 2-azahetaryl-3-énaminonitrile qui représentent une structure d'intérêt du fait de son nombre élevé de sites réactifs potentiels. La fonctionnalisation régiosélective de chaque site donne en effet accès à des une grande diversité structurelle de composés azoté et substitué par un azahétérocycle. Un atout majeur des 2-azahetaryl-2-(1-R-pyrrolidin-2-ylidene)acétonitriles est leur grande accessibilité à partir de matières premières simples et bon marché. Nous avons pu étudier leur emploi dans

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17

Hlimi, Fouzia. "Cycloaddition de diarylnitrilimines sur des dérivés de la benzodioxine 1,4 et de la benzoxazine-1,4 : regiochimie de la réaction sur un alcene portant un groupe donneur et un groupe accepteur sur la même extrêmité." Besançon, 1987. http://www.theses.fr/1987BESA2018.

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La cycloaddition dipolaire 1,3 des diarylnitrilimines sur le benzodioxinne-1,4 carboxylate-2 d'ethyle conduit a des cycloadduits qui apres ouverture donnent des derives de l'aryloxy-4 diphenyl-1,3 pyrazole qui ne sont pas accessibles par une methode classique de synthese de pyrazoles

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18

詹淑秦. "Investigation of synthesis and anti-allergic activityof 2-ethyl-3, 4-dimethylfuro [ 2, 3-c ] pyrazoles." Thesis, 1987. http://ndltd.ncl.edu.tw/handle/61087201187943624709.

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19

Liu, Po-Lin, and 劉柏麟. "One-pot Synthesis of 6-[(Formyl)methyl]-1H-pyrazolo[3,4-d]pyrimidines from 5-(2-Chloroacetylamino)pyrazoles and Bioactivity Study." Thesis, 2014. http://ndltd.ncl.edu.tw/handle/nfamc8.

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碩士<br>中國醫藥大學<br>藥物化學研究所碩士班<br>102<br>A new one-pot multicomponent reaction was successfully developed as a key strategy for the synthesis of 6-[(formyl)methyl]-1H-pyrazolo[3,4-d]- pyrimidine compounds from 5-(2-chloroacetylamino)pyrazoles with formamide in presence of PBr3. Under the reliable condition, the tandem multicomponent reactions involving Vilsmeier-Haack reaction, Morgan-Walls reaction, sequential elimination, substitution reaction, and final hydrolysis reaction efficiently afforded formylmethylpyrazolo[3,4-d]pyrimidine products in good yields (73–92%).

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20

Chen, Shiang-Chi, and 陳祥麒. "Microwave-mediated cycloaddition of 1,3-diphenylprop-2-yn-1-one to pyrazole and naphothofuran derivatives." Thesis, 2015. http://ndltd.ncl.edu.tw/handle/27362676310213208760.

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碩士<br>國立臺灣師範大學<br>化學系<br>103<br>This thesis is divided into three chapters. The first Chapter illustrates a convenient procedure for the one-pot synthesis of pyrazole derivatives. In this strategy, the initial step is the Michael addition of morpholine to 1,3-diphenylprop-2-yn-1-one to form an intermediate, and followed by the cycloaddition with phenylhydrazine under acidic condition. Here, we disclosed the reaction in traditional heating as well as microwave heating method. Chapter two, discribes the method for the synthesis of pyrazole under “on water” condition, supported by microwave heati

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21

Fang, Mei-Chi, and 方美琪. "Synthesis and anticancer activity of3-(5-hydroxymethyl-2-furyl)-1-phenyl-selenolo[3,2-c]pyrazole analogs." Thesis, 2009. http://ndltd.ncl.edu.tw/handle/81435999910390680889.

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碩士<br>中國醫藥大學<br>藥物化學研究所碩士班<br>97<br>1-Benzyl-3-(5-hydroxymethyl-2-furyl)indazole (YC-1) was has been identified as a potential antitumor agent. In order to extend the structure-activity relationships of YC-1 analogs, in this study a series of selenolo[3,2-c]pyrazoles were synthesized as target compounds. The key intermediates 7-8 were synthesized by reacting acyl chlorides 5-6 with methyl furan-2-carboxylate. The reacted intermediates 7-8 were then treated with phenylhydrazine or substituted phenylhydrazine to give the corresponding hydrazones 9-17. The above hydrazones were then treated with

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22

Yu, Jen-Kan. "The Photophysical Properties of The Complexes Containing 2-pyridyl pyrazole Family Ligands and Their Applications In OLEDs." 2004. http://www.cetd.com.tw/ec/thesisdetail.aspx?etdun=U0001-1407200417212900.

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23

Yu, Jen-Kan, and 余人侃. "The Photophysical Properties of The Complexes Containing 2-pyridyl pyrazole Family Ligands and Their Applications In OLEDs." Thesis, 2004. http://ndltd.ncl.edu.tw/handle/03083917190018572045.

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碩士<br>國立臺灣大學<br>化學研究所<br>92<br>Organic light-emitting devices have drawn a great deal of interests and are successively under intensive study due to their high electroluminescence (EL) efficiency all over the visible region. There are several advantages of the OLED displays over traditional LCD or LED displays. First, OLED based displays could be much thinner than the LCD panel, and are as responsive as the CRTs, people won’t see any smearing from slow pixel response time that usually take place in LCD panels. In addition, OLEDs are also superior to LCD panels in terms of viewing angle. Second

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24

"New mono- and dinuclear ruthenium complexes containing the 3,5-bis(2-pyridyl)pyrazole ligand. Synthesis, characterization and applications." Universitat de Girona, 2005. http://www.tesisenxarxa.net/TDX-0505105-110753/.

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25

Hsu, Cheng-Chih, and 徐丞志. "(1) High-Efficiency, Osmium(II)-Based Phosphorescent Materials: The Distinctive Photoluminescent Properties of Two Isomeric OsII Complexes Containing 2-pyridyl pyrazole Family Ligands(2)Ortho Green Fluorescence Protein Synthetic Chromophore; Excited-Sta." Thesis, 2007. http://ndltd.ncl.edu.tw/handle/25975439453857741781.

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碩士<br>國立臺灣大學<br>化學研究所<br>95<br>part 1. A general review of 2nd and 3rd – row transition-metal complexes incorporating chelating chromophores, which serves as phosphorescent dyes for organic light-emitting diodes, will be depicted in chapter 1. Group of Chi have synthesized two monometallic and isomeric complexes 3 and 4 with the coordination of two phosphine ligands located in the trans-disposition and one CO and one hydride located opposite to the pyridyl triazolate chelate. Chapter 2 focuses on subtle differences in photophysical properties examined for isomers 3 and 4 on the basis of steady

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26

JHANG, JIA-WEI, and 張家瑋. "Part 1: Design and Attempted Synthesis of Acridone Derivatives as Potential ABC Transporters Inhibitors,Part 2: Design and Synthesis of Pyrazole Derivatives as System xc- Inhibitors." Thesis, 2018. http://ndltd.ncl.edu.tw/handle/qg9258.

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碩士<br>東海大學<br>化學系<br>105<br>Part 1: ABC(ATP-binding cassette) transporter proteins are responsible for the cellular efflux of metabolites or toxic substances to protect cells. Overexpression of ABC transporter protein occur when tumor cells are stimulated continuously by chemotherapeutic drugs,that to causing lack of drug accumulation drugs which lead to development of multidrug resistance (MDR). The development of MDR is a major obstacle to successful chemotherapeutic treatment of cancer patients. Acridones are naturally occurring alkaloids and one of its derivatives, Elacridar was shown to

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27

Chou, Li-Chen, and 周立琛. "Synthesis and anticancer activity of 1,3,5-substituted selenolo[3,2-c]pyrazole analogues、Synthesis and anticancer activity of hydrophilic phosphate prodrugs of 2-phenyl-4-quinolone derivatives." Thesis, 2009. http://ndltd.ncl.edu.tw/handle/72588313584030324230.

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博士<br>中國醫藥大學<br>藥物化學研究所博士班<br>97<br>The purpose of this study is to develop compounds with potential anticancer activity as new drug candidate. This thesis consists of two parts. In the first part, four different skeletons of YC-1 derivatives [furopyrazole derivatives (11-22, 28-36), thienopyrazole derivatives (42-45, 50-53), selenopyrazole derivatives (67-72, 75-77), and indazole derivatives (99−118, 123−128)] were synthesized in order to expand the substance patent’s inclusion of YC-1 and find new candidate with better anticancer activity than YC-1, and constructed their SAR in NCI-H226 and

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28

Hsu, Cheng-Chih. "(1) High-Efficiency, Osmium(II)-Based Phosphorescent Materials: The Distinctive Photoluminescent Properties of Two Isomeric OsII Complexes Containing 2-pyridyl pyrazole Family Ligands (2)Ortho Green Fluorescence Protein Synthetic Chromophore; Excited-State Intramolecular Proton Transfer via a Seven-Membered-Ring Hydrogen-Bonding System." 2007. http://www.cetd.com.tw/ec/thesisdetail.aspx?etdun=U0001-0307200717191300.

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29

Prokofieva, Angelina. "Bioinspired oxidation reactions of phenols with dinuclear copper complexes." Doctoral thesis, 2007. http://hdl.handle.net/11858/00-1735-0000-000D-F12D-0.

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