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Dissertations / Theses on the topic '2-(Substituted)-1'

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Published: 5 June 2025

Last updated: 1 August 2025

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1

Negi, Shailendra. "Part 1: 5-substituted hydantoins by new preparative methods ; Part 2: synthesis and chemistry of unsaturated hydantoins /." The Ohio State University, 1996. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487940308430775.

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2

Valença, Jessica. "Análise conformacional e estudo das interações eletrônicas de alguns 2-heteroacetil-furanos -5 substituídos e do 2-cloroacetil-1-metilpirrol." Universidade de São Paulo, 2018. http://www.teses.usp.br/teses/disponiveis/46/46136/tde-19072018-135708/.

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A presente tese trata do estudo conformacional e do estudo das interações eletrônicas de alguns 2-(2-haloacetil)-5-substituído: furanos e 1-metilpirrol (Série I), como também dos 2-[2\'-(4\'- substituído-fenilsulfanil)-acetil]-5-metilfuranos, 2-(2\'-substituído-selenil-acetil)-5- metilfuranos (Série II) e 2-[2\'-(4\'- substituídos-fenilsufinil)-acetil]-5-metilfuranos (Série III) contendo substituintes doadores e atraentes de elétrons, além de hidrogênio, na posição 4 do grupo fenila. Foi constatada a ocorrência de isomerismo conformacional por espectroscopia no infravermelho em solventes de co

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3

Whipp, Christopher J. "Part 1: The Direct Arylation of Azine N-Oxides with Aryl Triflates Part 2: The Site-Selective Direct Arylation of Substituted Indoles." Thesis, University of Ottawa (Canada), 2010. http://hdl.handle.net/10393/28792.

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Part 1: The Direct Arylation of Azine N -Oxides with Aryl Triflates. Two sets of conditions for the palladium-catalyzed direct arylation of azine N-oxides with aryl triflates have been developed. Using palladium(II) acetate, a trialkylphosphine ligand, a carbonate base and pivalic acid, both mono- and diarylated azine N-oxides could be synthesized in good to excellent yields.* The reaction regioselectivity was examined for 3-substituted pyridine N-oxides, with arylation at C2 being favoured. The methodology was applied to the efficient formal synthesis of a biologically active diaryl pyridin

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4

Yeung, Ka Yim. "Studies on asymmetric reactions and catalysis using axially chiral 2-substituted N, N-dialkyl-1-naphthamides and p-chiral secondary phosphine oxides /." View Abstract or Full-Text, 2003. http://library.ust.hk/cgi/db/thesis.pl?CHEM%202003%20YEUNG.

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Thesis (Ph. D.)--Hong Kong University of Science and Technology, 2003.<br>Includes bibliographical references (leaves 196-207). Also available in electronic version. Access restricted to campus users.

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5

Anhettigama, Gamaralalage Medha Jaimini Gunaratna. "Design, synthesis and bio-evaluation of piperidines and CGRP peptides; Synthesis of substituted 6-(dimethylamino)-2-phenylisoindolin-1-ones for the inhibition of luciferase." Diss., Kansas State University, 2017. http://hdl.handle.net/2097/38204.

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Doctor of Philosophy<br>Department of Chemistry<br>Duy H. Hua<br>Three research projects are described in this dissertation, and they are: (i) discovery of piperidine derivatives as T-type calcium channel inhibitors for the treatment of epilepsy and neuropathic pain and as protein disulfide isomerase inhibitors for the treatment of influenza viral infection; (ii) discovery of peptide-based calcitonin gene-related peptide receptor antagonists for the treatment of inflammatory pain; and (iii) synthesis of substituted 6-(dimethylamino)-2-phenylisoindolin-1-ones for the inhibition of luciferase.

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6

Venham, Lanny Dean. "Kinetic studies of alpha-silyl radicals : 1) relative rates of bromination of substituted benzyltrimethylsilanes : 2) laser flash photolysis study of the absolute rates of formation of alpha-silyl radicals /." The Ohio State University, 1986. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487268021746361.

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7

Wieland, Laura Caroline. "Catalytic enantioselective synthesis of O- and N-substituted quaternary carbon stereogenic centers : 1. AL-catalyzed alkylations of α-ketoesters with dialkylzinc reagents. 2. AG-catalyzed vinylogous Mannich-type reactions of α-ketoimine esters with siloxyfurans". Thesis, Boston College, 2008. http://hdl.handle.net/2345/356.

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Thesis advisor: Amir H. Hoveyda<br>Chapter 1: We disclose an Al-catalyzed enantioselective method for additions of Me2Zn and Et2Zn to α-ketoesters bearing aromatic alkenyl, and alkyl substituents. These transformations are promoted in the presence of a readily available amino acid-based ligand, and afforded the desired products in excellent yields and in up to 95% ee. In addition, we discovered a remarkable enhancement of efficiency and selectivity in the presence of an achiral phosphoramidate additive. Chapter 2: An efficient diastereo- and enantioselective Ag-catalyzed method for additions o

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8

Jiuhong, Zhang. "Part I Development of a Synthetic Approach to O-thienyl Carboxylate Esters and Their Application in the Synthesis of Liquid Crystal Exhibiting SmC PhasePart II Synthesis and Photolytic Studies of pHP-and 1-Substituted-6,2-HNM-based HNO Donors." Kent State University / OhioLINK, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=kent1574715759256733.

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9

Aquino, Estefania da Costa. "Aplicação de 5-bromo-1,1,1-trifluor-4-metoxipent-3-en-2-ona na síntese de pirróis, pirazóis, pirimidinas e 1,2,3-triazóis." Universidade Federal de Santa Maria, 2015. http://repositorio.ufsm.br/handle/1/4275.

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Conselho Nacional de Desenvolvimento Científico e Tecnológico<br>This thesis reports the synthesis of various series of trifluoromethyl substituted nitrogenated heterocycles, such as pyrroles, pyrazoles, pyrimidines and 1,2,3-triazoles, exploiting the synthetic versatility of 5-bromo-1,1,1-trifluoro-4-methoxypent-3-en-2-one in reactions with nitrogenated nucleophiles. In this way, synthesis of a novel series of 4-amino-3-trifluoromethyl-1H-N-substituted pyrroles was performed through two reaction steps. In the first stage is an addition reaction of primary or secondary amine in the 4-position

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10

Allen, Damian Arthur. "Facile synthesis of cis-2-alkyl-3-trialkylsilyloxycycloalkanones via the non-aldol aldol rearrangement of 2,3-epoxycycloalkanols ; and, Use of 4-cyanocoumarins as dienophiles in a facile synthesis of highly substituted dibenzopyranones ; and, Progress toward the total synthesis of N-methylwelwitindolinone C isothiocyanate." Diss., Restricted to subscribing institutions, 2009. http://proquest.umi.com/pqdweb?did=1997737701&sid=1&Fmt=2&clientId=1564&RQT=309&VName=PQD.

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11

Kuang, Tsai-Chi, and 匡載麒. "Synthesis of 1-substituted benzyl-5(or 6) substituted 2-(5-methyl-2-furyl)benzimidazoles as antiplatelet drugs." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/74358954381439316314.

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碩士<br>中國醫藥大學<br>藥物化學研究所碩士班<br>99<br>In continuing development of novel aniplatelet agents, we had found that 1-benzyl-2-(5-methyl-2-furyl)benzimidazole (1) showed good platelet inhibitory activity. Compound 1 showed good inhibitory effect on the platelet aggregation induced by collagen, arachidonic acid, and U46619. Encouraged by this result, the compound 1 was selected as a lead compound and a series of 1-substituted benzyl-5(or 6)substituted-2-(5-methyl-2-furyl) benzimidazoles derivatives (4-19, 21-36, 42~51) were synthesized in this work. All the synthesized compounds were evaluated for

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12

Lin, Pei-Jung, and 林佩蓉. "Synthesis and antiplatelet activities of 1-substituted benzyl-5(or/and 6) substituted -2-(5-methyl-2-furyl)benzimidazoles." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/44262398013467540705.

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碩士<br>中國醫藥大學<br>藥物化學研究所碩士班<br>98<br>In continuing study of novel antiplatelet agents, we had found that 1-benzyl-2-(5-methyl-2-furyl) benzimidazole (1) exhibited good antiplatelet activity. Compound 1 showed good inhibitory effect on the platelet aggregation induced by collagen, arachidonic acid, and U46619. Encourage by this result, compound 1 was selected as a lead compound, and a series of 1-substituted benzyl-5(or/and 6) substituted- 2-(5-methyl-2- furyl)benzimidazoles (4~18, 20~34, 36~43, 45~52) were synthesized. All the synthesized compounds were evaluated for their antiplatelet activiti

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13

Hsieh, Ying-hsueh, and 謝英雪. "Synthesis and Antiplatelet Activity of 1-Substituted 2-(5'-methyl-2'-furyl)benzimidazoles." Thesis, 2000. http://ndltd.ncl.edu.tw/handle/31104378942560870981.

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碩士<br>中國醫藥學院<br>藥物化學研究所<br>88<br>To further explore the structure-activity relationship of YC-1 analogs in this work, I selected 5-methyl furfural (2) as starting material for condensation with o-phenyldiamine (1), in the precence of cupric acetate, to afford 2-(5´-methyl-2´-furyl) benzimidazole (3). Compound 3 was subsequently reacted with substituted benzyl chlorides to yield the 1-substituted benzl-2- (5´-methyl-2´-furyl)benzimidazoles (4~6). The antiplatelet activity of target compounds 3 and 4 were examined. Both compounds exhibit significant inhibitory effect against AA and co

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14

Solomon, Robert David. "The photochemistry of two 5,5-diphenyl substituted cyclohex-2-en-1-ones." 1986. http://catalog.hathitrust.org/api/volumes/oclc/13620916.html.

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Thesis (Ph. D.)--University of Wisconsin--Madison, 1986.<br>Typescript. Vita. eContent provider-neutral record in process. Description based on print version record. Includes bibliographical references (leaves 133-136).

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15

Mei-Ling, Shih, and 石美玲. "Synthesis, Antiplatelet, Antiangiogenesis and Cytotoxicity Activity of 1(or 2)-(Substituted benzyl)-3-(4-methylphenyl)-1(or 2)H-indazoles." Thesis, 2002. http://ndltd.ncl.edu.tw/handle/00339292517678059254.

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碩士<br>中國醫藥學院<br>藥物化學研究所<br>90<br>In order to search novel compounds with potent antiplatelet and antiangiogenesis activities, 3-(4-methylphenyl)-1H-indazole (6) was used as the key intermediate and its derivatives were synthesized. In the presence of triethylamine, 1-(N-morpholino)cyclohexene was reacted with 4-methylbenzoyl chloride. Followed by hydrolysis using dil. hydrochloric acid, 2-oxocyclohexyl 4-methylphenyl ketone (4) was obtained. 3-(4-Methylphenyl)-4,5,6,7-tetrahydro-1H-indazole (5) was gained after reaction of compound 4 and hydrazine. The product, 3-(4-methyl phenyl)

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16

Chang, Li-Juan, and 張麗娟. "Methanolysis of 2-Alkylbenzonitriles:Synthesis of 3-Substituted-1(2H)-isoquinolone and 3-Alkylidene isoindol-1-one." Thesis, 1998. http://ndltd.ncl.edu.tw/handle/56080644089999964538.

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碩士<br>高雄醫學院<br>藥學研究所<br>86<br>The treatment of 2-(2-alkylethynyl) benzonitrile with sodium methoxide in methanol gave 3-alkyl-1(2H)-isoquinolinone in modest yield. Under the same reaction conditions methanolysis of 2-(2-arylethynyl)benzonitrile lead to the formation of 3-alkylidene isoindol-1-one. Partial hydrolysis of 2- (1-hexynyl) benzonitrile to the corresponding benzamide, followed by the treatment of the benzamide with sodium methoxide gave 3-pentylidene isoindol-1-one in 11% yield. T

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17

Yu, Pin-Chih, та 余品志. "(一) Pyrolytic and photolytic studies of substituted styrylarenes(二) Pyrolytic studies of 2-inden-1-ylidenemethylthiophene and 2-inden-1-ylidenemethylfuran". Thesis, 2007. http://ndltd.ncl.edu.tw/handle/t2sz45.

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博士<br>國立中山大學<br>化學系研究所<br>96<br>The first chapter describe the pyrolytic and photolytic studies of substituted styrylarenes. Flash vacuum pyrolysis (FVP) of (2-(4-methoxystyryl)-N-methylindole) (18) gave (4-vinylphenol) (81)、 (7-methyl-7H-benzo[c]carbazole) (82)、 (benzo[c]carbazole) (83)、 (1,6-dihydrocyclopenta[c]carbazole) (84) and (3,6-dihydrocyclopenta- [c]carbazole) (84''). FVP of 2'',3,5-trimethoxystilbene (31) gave 2-(3,5-dihydroxyphenyl)benzo[b]furan) (26) and 2-(3,5-dimethoxy- phenyl)benzo[b]furan (95). FVP of 2-methoxy-4-(methoxymethyl)-1- [2-(4-methoxyphenyl)-1-methylvinyl]benzene (3

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18

Chen, Wei-Cheng, and 陳偉政. "(1) The Synthesis and Chemistry of 9-Substituted Bicyclo[6.1.0]non-1(9)-enes ; (2) The Synthesis and Reactions of (E)-3-phenyl-1-[(phenylsulfonyl)imino]-2-propene." Thesis, 2000. http://ndltd.ncl.edu.tw/handle/08933636138787785869.

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碩士<br>輔仁大學<br>化學系<br>88<br>(1) 9-Chlorobicyclo[6.1.0]non-1(9)-ene (75) and 9-bromobicyclo- [6.1.0]non-1(9)-ene (37) were synthesized by dehalo- genation of 9,9-di- bromo-1-chlorobicyclo[6.1.0]nonane (74) and 1,9,9-tribromobicyclo- [6.1.0]nonane (36). Compound 37, an intermediate for the preparation of 9-substituted bicyclo[6.1.0]non-1(9)-enes, underwent bromo-lithium exchange followed by nucleophilic substitution reactions to generate bi- cyclo[6.1.0]non-1(9)-ene (39), 9-methylbicyclo[6.1.0]non- 1(9)-ene (34), and 9-trimethylsilylbicyclo[6.1.0]non-1(9)-ene (98). The bicyclic

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19

Li, Jian-Kuan, and 李建寬. "Synthesis and antiplatelet activities of 1-substituted benzyl-5(or 6 or 5,6 )halo-2-(5-methyl-2-furyl)benzimidazoles." Thesis, 2013. http://ndltd.ncl.edu.tw/handle/7n7a4b.

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碩士<br>中國醫藥大學<br>藥物化學研究所碩士班<br>101<br>In continuing development of novel aniplatelet agents, we had found that 1-benzyl-2-(5-methyl-2-furyl)benzimidazole (1) showed good platelet inhibitory activity. Compound 1 showed good inhibitory effect on the platelet aggregation induced by collagen, arachidonic acid, and U46619. Encouraged by this result, the compound 1 was selected as a lead compound and a series of 1-substituted benzyl-5(or 6 or 5,6)substituted-2-(5-methyl-2-furyl) benzimidazoles derivatives (3-18,19-43) were synthesized in this work. All the synthesized compounds were evaluated for

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Wu, Cheng-Lung, and 吳承龍. "(1) Asymmetric Synthesis of a meso-Dicarboxylic Anhydride Employing Grignard Reagent (2) Synthesis of 2-substituted-4,5-dihydro-1H-imidazole derivatives." Thesis, 2004. http://ndltd.ncl.edu.tw/handle/83630691181120414314.

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Fu, Kai-Ling, and 傅凱伶. "The Study of Microwave Accelerated Organic Reaction(1) Synthesis of N-Phenylanthranilic Acids(2) Synthesis of N-Substituted Pyrrole-2-carboxaldehyde." Thesis, 2006. http://ndltd.ncl.edu.tw/handle/45843931195172457629.

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碩士<br>中興大學<br>化學系所<br>94<br>We report herein our studies on microwave-assisted N-phenylanthranilic acids formation and the synthesis of N-substituted pyrrole-2-carboxaldehyde. I. Preparation of N-phenylanthranilic acids The reaction times of the formation of N-phenylanthranilic acids, by reacting o-chlorobenzoic acid and substituted aniline, were greatly reduced from 2~4 hours in conventional method to 10 min by using domestic microwave irradiation at 800 W, and focused microwave irradiation at 270 W, while the yields were comparable. The above reaction did not work under neat or solid sup

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22

Zhu, Zhaoning. "Solving the mystery of solid state reactivity crystalline photochemistry of substituted 4,4-diphenylcyclohex-2-en-1-ones /." 1994. http://catalog.hathitrust.org/api/volumes/oclc/32425496.html.

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23

Tang, Hsien-Yu, and 湯先佑. "Synthesis and Biological activities of 1-Substituted Benzyl-3(or5)-(5-hydroxymethyl-2-furyl)-5(or3)- phenylpyrazoles." Thesis, 2006. http://ndltd.ncl.edu.tw/handle/90515139873642364500.

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碩士<br>中國醫藥大學<br>藥物化學研究所碩士班<br>94<br>As a part of our continuing search for potential aniplatelet agent, 1-Benzyl-3-(5-hydroxymethyl -2-furyl)-5-phenylpyrazole (7b) was chosen as the lead compund. The starting material was methyl 2-furoate(1), which was introduced by hydrogen chloride and paraformadehyde to prepare methyl 5-chloromethyl-2-furoate (2). The compound 2 was successively reacted with hexamethelentetramine, then hydrolysis the formed salt, and methyl 5-formyl-2-furomate (3) was yield. Compound 4 was obtained from compound 3, which reacted with acetophenone in alkaline. And then

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Rico, Duque Jenny Lorena. "Synthesis of 1,2-methano-tetrahydrofuran derivatives and 1´,2´-methano-2´,3´-dideoxynucleosides as potential antivirals." Thèse, 2018. http://hdl.handle.net/1866/20042.

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Ho, Guo Ming, та 何國銘. "1.Chiral [3,3]-sigmatropic Rearrangement Studies of γ-Allyloxy Substituted Vinylogous Urethane 2. [2,3]-Wittig Rearrangement Studies of γ- 2∘Allyloxy Substituted Vinylogous Urethane 3.Asymmetric [2,3]-Wittig Rearrangement Studies and Synthetic A". Thesis, 2006. http://ndltd.ncl.edu.tw/handle/41734933025861545871.

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碩士<br>國立嘉義大學<br>應用化學系研究所<br>94<br>1. Chiral [3,3]-Sigmatropic Rearrangement Studies of γ-Allyloxy Substituted Vinylogous Urethane Pyrrolidine derivatives 1 and 2 were condensed with various of achiral γ-allyloxy substituted ketoesters to generate vinylogous urethanes. Thermo [3,3]-Sigmatropic rearrangement of these vinylogous urethanes were studied to investigate their reactivities and diastereoselectivities . 2. [2,3]-Wittig Rearrangement Studies of γ- 2∘Allyloxy Substituted Vinylogous Urethane Racemic and chiral γ- 2∘cyclic allyloxy substituted vinylogous urethane were used t

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Chang, Ho-Chiang, and 張豪晉. "1. Synthesis of Substituted 1-Benzoxepin-2-one from Isovanillin via Ring-Closing Metathesis (RCM)2. A New Approach for the Synthesis of Mellein Derivatives from Isovanillin via 3,4-Dihydro-2-chroman Intermediate." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/88918019211283716041.

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碩士<br>高雄醫學大學<br>醫藥暨應用化學研究所<br>98<br>Part I Isovanillin was used as starting material which underwent sequential reactions such as O-alkylation, and ring-closing metathesis (RCM) to provide substituted 1-benzoxepin-2-one derivatives. Part II Utilization of O-alkylation, Claisen rearrangement, reduction, oxymercuration-demercuration and oxidation in sequences, a series of mellein derivatives were synthesized via 3,4-dihydro-2-chroman intermediate from isovanillin.

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Hao, Bo. "Asymetric oxidation reactions catalyzed by chiral substituted polymers / nanoclusters; synthesis of 6-(dimethylamino)-2-phenylisoindolin-1-one derivative." Diss., 2018. http://hdl.handle.net/2097/38904.

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Doctor of Philosophy<br>Department of Chemistry<br>Duy H. Hua<br>The discovery of new methodologies to advance the fields of synthetic organic, nanoclusters, and polymer chemistry is critical in the asymmetric synthesis of organic compounds. Particularly, catalytic asymmetric oxidation reactions are economic. The oxidation reactions provide chiral molecules and additional functionality onto the molecules for functional group manipulation. New kinds of polymers, namely chiral-substituted poly-N-vinylpyrrolidinones (CSPVPs), stabilize the bimetallic nanoclusters such as Pd/Au or Cu/Au and induce

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HSIAO, FU-CHIN, and 蕭富今. "(1)The mechanism study of the reaction of (E)-3-Phenyl-1-[(phenylsulfonyl)imino]-2-propene with alkyl lithium (2)The Synthesis and Chemistry of 7-Substituted Bicyclo[4.1.0]hept-1(7)-enes." Thesis, 2003. http://ndltd.ncl.edu.tw/handle/59654467214080950712.

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碩士<br>輔仁大學<br>化學系<br>91<br>Abstract (1) When (E)-3-phenyl-1-[(phenylsulfonyl)imino]-2-propene(1) was treated with 2 equivalent methyl lithium(MeLi),five compounds-2, 3, 4, 5, and 6 were isolated. The formation of products 3 and 6 were studied. Compound 2 was treated with 2 equivalent MeLi to produce dianion 25.Dianion 25 underwent intramolecular reaction and reacted with water and deprotonation to generate anion 26 follwed by ring opening and proton absorption to form compound 3. The formation of 6 is via carbanion exchange from methyl carbanion to

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Tsai, Ray-Ying, and 蔡睿盈. "Synthesis，Antiplatelet，Antiangiogenesis and Cytotoxicity Activity of 1-Benzyl-3-(5-substituted-2-furyl)-5-methoxy-1H-indazole Derivatives." Thesis, 2003. http://ndltd.ncl.edu.tw/handle/68278761980375752184.

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碩士<br>中國醫藥學院<br>藥物化學研究所<br>91<br>Abstract 1-Benzyl-3-(5'-hydroxymethyl-2'-furyl)indazole (YC-1) was first synthesized in our laboratory as a novel antiplatelet agent. Encouraged by the initial results, a series of 5-methoxy derivatives of YC-1 analogues were synthesized and examined for their biological activities. The starting material methyl 5-(3-methoxybenzoyl)-2-furoate (1) was treated with benzylhydrazine to yield a mixture of E- and Z-form isomers 2. The hydrazone was then treated with lead tetraacetate in dichloromethane at low temperature, then boron trifluoride e

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Chen, Po-Yuan, and 陳伯淵. "New syntheses of benzoheterocyclic derivatives: (i) flavanones; (ii) 2-substituted 3-benzylbenzofurans and (iii) 3,4-dihydroisoquinolin-1(2H)-ones." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/87931651625025683656.

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博士<br>高雄醫學大學<br>醫藥暨應用化學研究所<br>100<br>Chapter I Mild and environmentally benign methods for the syntheses of flavanones are described. The reaction of o-hydroxyacetophenones (I-1) and benzaldehydes (I-2) in water in the presence of DABCO at room temperature gave 3-hydroxy-1-(2-hydroxylphenyl)-3-arylpropan-1-ones (I-3a-i) as intermediates. Followed by an intramolecular dehydration of the 3a-i with the modified Mitsunobu’s reaction, the target flavanones (I-4a-i) were obtained. Moreover, the reaction of I-1 and I-2 at the same conditions but at reflux gave flavanones in one pot with good yields.

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Lin, Mei-Ching, and 林美靜. "1. Pronounced Effects of Grinding on Rates of Intramolecular Electron Transfer in Tetranaphthylmethyl Substituted Mixed- Valence Biferrocenium Triiodide.2. The Application of Terpyridinyl Substituted Biferrocene Complexes in the Development of Molecular." Thesis, 2003. http://ndltd.ncl.edu.tw/handle/52192407365530512672.

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博士<br>國立中山大學<br>化學系研究所<br>91<br>Ch1 The X-ray structural determinations of the neutral 1'',2'',1''",2''"-tetranaphthylmethyl- and the 1'', 3'', 1'', 3''-tetranaphthylmethyl- biferrocenium triiodide have been determined. Our Mossbauer measurement for 1.34 and 1.35 indicate that the intramolecular electron transfer rates are quite sensitive to the environmental perturbations caused by the grinding of the sample. An interesting finding is that the Mossbauer results indicate that the unground diffusing sample of 1.34 is valence delocalized on the Mossbauer time scale above 180K. However, the groun

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Lu, Ping-Hsun, and 呂秉勳. "1. Synthesis and Anti-SARS-coV Activity of promazine analogues. 2. Synthesis and Anti-Cancer Activity of 3-Phenoxy Substituted Indole Analogues." Thesis, 2005. http://ndltd.ncl.edu.tw/handle/73603118436885853669.

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碩士<br>國立清華大學<br>化學系<br>93<br>Abstract The thesis consists of two parts: the first part is concerned with the synthesis and bioassay of promazine analogues and the second part describes the synthesis and anti-cancer activity of 3-phenoxy substituted indole analogues. The first part : The global outbreak of severe acute respiratory syndrome (SARS) caused by a novel coronavirus began in March 2003. An in-house chemical library consisting of 800 marketed drugs was evaluated for anti-SARS-CoV activities. We began our drug screening using porcine transmissible gastroenteritis virus (TGEV) as the sur

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Tsai, Bing-Chun, and 蔡秉均. "Study on the Diels-Alder reactions of Masked 4-Substituted-o-benzoquinones and (1S)-7,7-dimethyl-1-(nitrosocarbonyl)bicyclo[2.2.1]heptan-2-one." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/03433490902253408996.

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碩士<br>中原大學<br>化學研究所<br>100<br>This thesis is concerned with asymmetric nitroso-Diels-Alder (ANDA) reactions of masked-o-benzoquinones (MOBs) with nitroso dienophiles deriver from (+)-camphorsulfonic acid. The studied reactions gave 75%-89% yield and 83%-99% disastereoselsetivities and the relationship between specific rotation and absolute configuration of the ANDA products were determined by HPLC and X-ray crystallography.

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Chen, Chia Jung, and 陳家蓉. "(1)Synthesis of N,N’-disubstituted guanidine derivatives by Brønsted acid-catalyzed reaction of N-substituted cyanamides with arylamines (2)Copper-catalyzed cyclization reaction of N-(2-bromophenyl)-N’-arylguanidines." Thesis, 2016. http://ndltd.ncl.edu.tw/handle/7xfv4j.

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碩士<br>國立臺灣師範大學<br>化學系<br>104<br>2-Phenylaminobenzimidazoles and N,N'-diarylguanidines are common nitrogencontaining chemical scaffolds which displayed a wide range of pharmacological activities, such as antitumor, anti-hypertension and anti-HIV-1 virus activities. Therefore, the synthesis of these nitrogen-containing compounds has always been of great interest to organic chemists. 2-Phenylaminobenzimidazoles can be considered as a cyclic form of N,N'-diarylguanidines. Herein, we will discuss their background, importance and synthesis in two major parts. In the first part, our group has recentl

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Liou, Jia-Chie, and 劉家齊. "(1) Novel Synthetic Approaches to Alkoxy-Substituted Oligo-( para -Phenylene-(E)-Vinylene)s (2) S,S-Dimethyl Dithiocarbonate, A Novel Reagent For Polyurea Synthesis." Thesis, 1996. http://ndltd.ncl.edu.tw/handle/80341996920888660361.

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Mmonwa, Mmakwena Modlicious. "Synthesis of Polyaryl-substituted Bisquinazolinones with potential photophysical properties." Diss., 2014. http://hdl.handle.net/10500/18789.

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3,5-Dibromo-2-aminobenzamide was reacted with 1,3-cyclohexanedione derivatives in the presence of iodine as catalyst in toluene under reflux to afford novel 6,8-dibromo-2-[3-(2´-alkyl-1´,2´,3´,4´-tetrahydro-6´,8´-dibromo-4´-oxoquinazoline-2yl)propyl]quinazolin-4(3H)-ones in high yields. Suzuki-Miyaura cross-coupling of the latter with arylboronic acids in the presence of Pd(PPh3)2Cl2–Xphos catalyst complex and K2CO3 as a base in dioxane-water mixture (3:1, v/v) afforded the corresponding polyaryl-substituted bis-heterocycles in a single step operation. The resultant compounds were characterize

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Lin, Yu-Li, and 林于莉. "(1)Synthesis of Substituted 5,14-dihydro-8H-13-oxadibenzo[a,f]cyclodecene via Ring-Closing Metathesis(2)Conversion of alcohols into alkyl halides via Mitsunobu reaction." Thesis, 2004. http://ndltd.ncl.edu.tw/handle/94191663620512138344.

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碩士<br>高雄醫學大學<br>醫藥暨應用化學系碩士班<br>92<br>Part Ⅰ As part of an ongoing study of the chemistry of benzoheterocyclic compounds, a series of 10-membered macrocyclic ethers annulated with substituted benzene is described. O-allylbenzylalcohols and O-allyl- phenols, derived from isovanillin, were coupled by the Mitsunobu reaction to construct the intramolecular dienes as precursor for ring- closing metathesis (RCM). Finally, by the treatment of Grubbs’ catalyst the intramolecular dienes were cyclized to give the desired compounds, 10-membered macrocyclic ethers, respectively. Part Ⅱ Two new methods for

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Lin, Yu-Wei, and 林鈺偉. "(1) A Proposed Entry to Intermediates of Antiretroviral drugs: Facile Synthesis of Highly Substituted g-Lactams Possessing Phosphorus Ylides. (2) Property of the Open-Cage Fullerene." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/19578254164070993971.

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碩士<br>國立交通大學<br>應用化學系碩博士班<br>99<br>Antiretroviral drug have been developed in recent years and some antiretroviral drugs are commercial available. For example, Amprenavir and Indinavir are some of these commercial available drugs. Issues of some side effects and the cost for production of these antiretroviral drug have been primary concerns. Highly-efficient and low-cost synthetic procedures for drug syntheses can be conducive to human. Some gamma-lactam antiretroviral drugs have been reported, such as gamma-lactam-like Amprenavir and Indinavir. Because these drugs are gamma-lactam derivatives

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Chen, Zhong-Yi, and 陳忠毅. "1. 1. Studies in Synthesis of C-1 Substituted Fulvenes via the Oxidation-Addition of Haloacetyl Halide to fulveneketene Acetal. 2. Traceless Solid-Phase Synthesis of Cyclopenta[c]quinolines and Cyclopenta[c]chromenes via Hetero [6+3] Cycloadditions of Fu." Thesis, 2003. http://ndltd.ncl.edu.tw/handle/12983595954471742161.

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博士<br>國立中正大學<br>化學研究所<br>91<br>1.Studies in Synthesis of C-1 Substituted Fulvenes via the Oxidation-Addition of Haloacetyl Halide to fulveneketene Acetal. In contrast to the [2+2] cycloaddition of fulvenes and ketenes, fulveneketene acetal, 2-chloropentadienylidene-1,3-dioxalane, reacts with a-halo acyl halides to give various C-1 substituted fulvene. Herein we describe the first example of oxidative-addition of a-chloroacetyl chloride to fulveneketene acetal, and formal synthesis of the carbocyclic analogs of Captopril. 2.Traceless Solid-Phase Synthesis of

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Chen, Bo-Fong, and 陳伯峰. "1. A Versatile Approach to 6-Substituted-5-methoxy-d-lactam Framework and Application to the Synthesis of Natural Products and Pharmaceuticals 2. A New Approach to Isoindolone Skeleton." Thesis, 2004. http://ndltd.ncl.edu.tw/handle/54215609877262062807.

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博士<br>國立中山大學<br>化學系研究所<br>93<br>1. The key glutarimides were obtained via facile [3+3] annulation. The method featured regioselective introduction of C-6 substituents in glutarimides, and application to the synthesis of natural products and pharmaceuticals. 2. The synthesis of a novel substituted aza-ticyclic compounds through the use of the intramolecular Diels-Alder reaction is present. Further aromaticzation in the present of BF3 to afford 2,3-dihydro-isoindolone.The use of method for the rapid preparation of a substituted isoindolone framework is described.

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CHEN, JUNG-HSUAN, and 陳蓉萱. "1. An Efficient and Convenient Synthesis of Fully-Substituted 1,2,3-Triazole 2.Organocatalytic Domino Michael /Hemiacetalization of beta-Tetralone and alpha,beta-Unsaturated Aldehydes 3. Total Synthesis of (±)-Viroallosecurinine." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/89468652340197012528.

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博士<br>國立臺灣師範大學<br>化學系<br>100<br>There are three parts of research topics in this thesis. The first topic is an alternative and direct access to fully-substituted 1,2,3-triazoles. Treatment of diazo compound with 4-methoxyaniline derived aryl imines in the presence of DBU provided ethyl 1-(4-methoxyphenyl)-5-phenyl-1H-1,2,3-triazole-4-carboxylate in good to high yields. A reasonable mechanism is proposed that involves the addition of an imine nitrogen atom to the terminal nitrogen atom of the diazo compound, followed by aromatization to give the 1,2,3-triazole. The presence of the 4-carboxy gro

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C, Chaitra, and S. Sharada D. "Palladium Catalyzed Aerobic Oxidative Isocyanide Insertion Leading to 2-Amino Substituted 4(3H)-Quinazolinones." Thesis, 2014. http://raiith.iith.ac.in/100/1/CY12M1008.pdf.

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An efficient one-pot cascade aerobic oxidative palladium-catalyzed multicomponent reaction was developed through isocyanide insertion between less active amide NH and aromatic amine. This approach leads to an efficient synthesis of 2- amino-substituted 4(3H)-quinazolinones.

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Schnaubelt, Linda. "Redox-coupled Spin Transition in Co(2+/3+) Complexes with Triarylamine-substituted Polypyridyl-based Ligands." 2019. https://monarch.qucosa.de/id/qucosa%3A34787.

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The present PhD thesis describes the synthesis and characterisation of Co(2+/3+) complexes with triarylamine-substituted polypyridyl-based ligands. A light- or temperature-induced intramolecular electron transfer between the Co and the triarylamine moieties was found in the tri-cationic complexes, which was examined with electrochemical measurements, DFT calculations, optical and dynamic 1H NMR spectroscopy. This process is coupled to a high-spin <--> low-spin transition on the metal. The emphasis of this PhD thesis was the adjustment of a redox equilibrium between the paramagnetic ([Co2+(L+)(

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Sehlotho, N., T. Nyokong, J. H. Zagal, and F. Bedioui. "Electrocatalysis of oxidation of 2-mercaptoethanol, l-cysteine and reduced glutathione by adsorbed and electrodeposited cobalt tetra phenoxypyrrole and tetra ethoxythiophene substituted phthalocyanines." 2006. http://eprints.ru.ac.za/448/1/Nyokong_Electrocatalysis.pdf.

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Catalytic activity of cobalt tetra ethoxythiophene and cobalt tetra phenoxypyrrole phthalocyanine complexes towards oxidation of 2-mercaptoethanol, L-cysteine and reduced glutathione is reported. It was found that the activity of the complexes depends on the substitution of the phthalocyanine ring, pH, film thickness and method of electrode modification. The high electrocatalytic activity obtained with adsorbed complexes in alkaline medium clearly demonstrates the necessity of modifying bare carbon electrodes to endow them with the desired behaviour.

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