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1

Sugimoto, Toyonari, Kazumasa Ueda, Satoshi Endo, et al. "1:2 Dimethyl-substituted tetracyanoquinodimethane." Chemical Physics Letters 288, no. 5-6 (1998): 767–75. http://dx.doi.org/10.1016/s0009-2614(98)00343-1.

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2

De Napoli, Lorenzo, Anna Messere, Daniela Montesarchio, Gennaro Piccialli, and Michela Varra. "1-Substituted 2′-deoxyinosine analogues." Journal of the Chemical Society, Perkin Transactions 1, no. 14 (1997): 2079–82. http://dx.doi.org/10.1039/a700987i.

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3

Chen, Chi-Li, and Stephen F. Martin. "Facile Synthesis of 2-Substituted 1,2-Dihydro-1-naphthols and 2-Substituted 1-Naphthols." Organic Letters 6, no. 20 (2004): 3581–84. http://dx.doi.org/10.1021/ol048517t.

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4

Zakharychev, V. V., and A. V. Kuzenkov. "Synthesis of substituted 1-(2-arylvinyl)-2-azolyl-1-pyridylethanols-1." Chemistry of Heterocyclic Compounds 43, no. 8 (2007): 989–95. http://dx.doi.org/10.1007/s10593-007-0154-2.

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5

KIM, J. C., M. D. KONG, M. Y. YOON, J. I. PARK, and S. K. CHOI. "ChemInform Abstract: Unusual Rearrangement of 2-Amino-1-substituted-phenyl-1-alkanol to 1- Substituted-phenyl-2-alkanone." ChemInform 27, no. 32 (2010): no. http://dx.doi.org/10.1002/chin.199632118.

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6

Chirkova, Zh V., M. V. Kabanova, S. I. Filimonov, A. V. Samet, G. A. Stashina, and T. N. Sudzilovskaya. "Chlorination of 2-substituted 1-hydroxyindoles." Russian Chemical Bulletin 67, no. 6 (2018): 1083–87. http://dx.doi.org/10.1007/s11172-018-2184-6.

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7

Razus, Alexandru C., Carmen Nitu, Victorita Tecuceanu, and Valentin Cimpeanu. "2-Substituted (Azulen-1-yl)ethenes." European Journal of Organic Chemistry 2003, no. 23 (2003): 4601–10. http://dx.doi.org/10.1002/ejoc.200300346.

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8

Tamazyan, Rafael, Harutyun Karapetyan, Ashot Martirosyan, Vahagn Hovhannesyan, and Sahak Gasparyan. "1-Substituted derivatives of 2-phenylpyrrolidine-2-carboxamide." Acta Crystallographica Section C Crystal Structure Communications 58, no. 7 (2002): o386—o388. http://dx.doi.org/10.1107/s0108270102008636.

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9

C., D. PATIL, S. SADANA G., and D. DEODHAR K. "Syntheses of 2-Substituted-1 ,2-dihydro-1-oxo-4-isoquinoline carboxamides and 4-Amisoximino-2-substituted-1 ,2- dihydro- I -oxoisoquinolines as Antimicrobial Agents." Journal Of Indian Chemical Society Vol. 67, Aug 1990 (1990): 654–56. https://doi.org/10.5281/zenodo.6222077.

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Department of Chemistry, G. N. Khalsa College, Bombay-400 019 Department of Chemistry, Indian Institute of Technology, Bombay-400 076 Manuscript received 15 January 1990, revised  27 March 1990, accepted 10 .April 1990 Various substituted-1-oxolsoquinolines were prepared starting with homophthalic anhydride. The intermediate aminomethylene homophthalic anhydride yields-1-oxoisoquinoline acids and amides in presence of 10% solution of sodium hydroxide and secondary amine respectively. The substituted-1-oxoisoquinoline acids were then converted to substituted amidoximino-1-oxoisoq
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10

Volynskii, N. P., and O. L. Alikhanova. "Synthesis of 3-substituted trans-2-oxadecalins and 1-substituted trans-2-oxahydrindanes." Bulletin of the Academy of Sciences of the USSR Division of Chemical Science 40, no. 8 (1991): 1652–63. http://dx.doi.org/10.1007/bf01172270.

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11

Volynskii, N. P., and O. L. Alikhanova. "Synthesis of 1-substituted trans-2-thiahydrindanes and 3-substituted trans-2-thiadecalins." Bulletin of the Academy of Sciences of the USSR Division of Chemical Science 40, no. 8 (1991): 1664–71. http://dx.doi.org/10.1007/bf01172271.

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12

C., Venkateswarlu, V. V. Satyanarayana P., V. Nageswara Rao C. та Naga Raju C. "Synthesis and spectral characterization of 2-(substituted)-1,3,2λ5-oxazaphosphinan-2-ones/-2-thiones". Journal of Indian Chemical Society Vol. 87, Oct 2010 (2010): 1273–77. https://doi.org/10.5281/zenodo.5805058.

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Department of Chemistry, K. V. R. College, Nandigama-521 185, Andhra Pradesh, India Department of Chemistry, Acharya Nagarjuna University, Nagarjunanagar-522 510, Andhra Pradesh, India P.G. Department of Chemistry, AG &amp; SG Siddhartha College of Arts &amp; Science, Vuyyuru-521 165, Andhra Pradesh, India <em>E-mail :</em> chavavnrao@gmail.com Department of Chemistry, Sri Venkateswara University, Tirupati-517 502, Andhra Pradesh, India <em>Manuscript received 11 February 2010. accepted 28 April 2010</em> 2-(Substituted)-1,3,2&lambda;<sup>5</sup>-oxazaphosphlnan-2-ones/-2-thiones (3-10) were s
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13

V., Sareen, Khatri V., Shinde D., and Sareen S. "Synthesis of some novel (1-substituted-5-phenyl-3-trifluoromethyl-1H-pyrazol-4- yl)-(substituted benzothiazol-2-yl)-diazene and their antifungal activity." Journal of India Chemical Society Vol. 87, Nov 2010 (2010): 1415–19. https://doi.org/10.5281/zenodo.5805986.

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Department of Chemistry, University of Rajasthan, Jaipur-302 004, Rajasthan, India <em>E-mail:</em> sareenparmod@yahoo.com <em>Manuscript received 24 February 2010, revised 6 April 2010. accepted 31 May 2010</em> Diazonium sult of substituted 2-aminobenzothlazole (I) bas been reacted with 1-phenyl-4,4,4-trifluorobutam- 1,3-dione (2) to give compound 3 which on&nbsp;reaction with different hydrazines gives 1-substltuted-5-pbenyl-3-trifluoromethyl- 1<em>H</em>-pyrazol-4-yl)-(subslituted-benzotblazol-2-yl)-diazene (4). These compounds have been evaluated for their antlfungal activity. The structu
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14

Kuzenkov, A. V. "Synthesis of Substituted 2-Azolyl-1-pyridylethan-1-ols." Chemistry of Heterocyclic Compounds 39, no. 11 (2003): 1492–95. http://dx.doi.org/10.1023/b:cohc.0000014414.45065.f2.

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15

Subudhi, BB, D. Bhatta, PK Panda, P. Mishra, and D. Pradhan. "Synthesis and antiulcer activity studies of 2-(1'-iminothioimido substituted)-1'-substituted phenylbenzoic acids." Indian Journal of Pharmaceutical Sciences 70, no. 3 (2008): 381. http://dx.doi.org/10.4103/0250-474x.43009.

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16

Arnoldi, Anna, and Marica Carughi. "A Simple Synthesis of 2-Substituted 1-Benzothiophenes and 3- Substituted 2H-1-Benzothiopyrans." Synthesis 1988, no. 02 (1988): 155–57. http://dx.doi.org/10.1055/s-1988-27501.

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17

Kavina, M. A., V. V. Sizov, and I. P. Yakovlev. "Synthesis of substituted 2-(2-oxopyrrolidin-1-yl)acetamides." Russian Journal of Organic Chemistry 53, no. 6 (2017): 873–78. http://dx.doi.org/10.1134/s1070428017060100.

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18

Frontana-Uribe, B. A., C. Moinet, and L. Toupet. "N-Substituted 1-Aminoindoles from ElectrogeneratedN-Substituted 2-(ortho-Nitrosophenyl)ethylamines." European Journal of Organic Chemistry 1999, no. 2 (1999): 419–30. http://dx.doi.org/10.1002/(sici)1099-0690(199902)1999:2<419::aid-ejoc419>3.0.co;2-v.

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19

Almena, Inés, Mikael Begtrup, Antonio de la Hoz, et al. "Deprotonation of 2-Substituted Pyrazole 1-Oxides." Acta Chemica Scandinavica 46 (1992): 1096–100. http://dx.doi.org/10.3891/acta.chem.scand.46-1096.

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20

Lovell, James M., and John A. Joule. "Synthesis of 1- and 2-substituted thianthrenes." Journal of the Chemical Society, Perkin Transactions 1, no. 19 (1996): 2391. http://dx.doi.org/10.1039/p19960002391.

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21

Nazarinia, M., A. Sharifian, and A. Shafiee. "Syntheses of substituted 1-(2-phenethyl)pyrazoles." Journal of Heterocyclic Chemistry 32, no. 1 (1995): 223–25. http://dx.doi.org/10.1002/jhet.5570320137.

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22

DE NAPOLI, L., A. MESSERE, D. MONTESARCHIO, G. PICCIALLI, and M. VARRA. "ChemInform Abstract: 1-Substituted 2′-Deoxyinosine Analogues." ChemInform 28, no. 51 (2010): no. http://dx.doi.org/10.1002/chin.199751244.

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23

Stoyanov, V. M., M. M. El'chaninov, A. M. Simonov, and A. F. Pozharskii. "2-Substituted imidazoles. 1. Reactions of 1-methyl-2-(2-furyl)imidazole with electrophiles." Chemistry of Heterocyclic Compounds 25, no. 10 (1989): 1168–72. http://dx.doi.org/10.1007/bf00470698.

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24

VOLYNSKII, N. P., and O. L. ALIKHANOVA. "ChemInform Abstract: Synthesis of 1-Substituted trans-2-Thiahydrindans and 3-Substituted trans-2-Thiadecalins." ChemInform 23, no. 25 (2010): no. http://dx.doi.org/10.1002/chin.199225066.

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25

Verma, Deepak, Pradeep Kumar, Balasubramanian Narasimhan, et al. "Synthesis, antimicrobial, anticancer and QSAR studies of 1-[4-(substituted phenyl)-2-(substituted phenyl azomethyl)-benzo[b]-[1,4]diazepin-1-yl]-2-substituted phenylaminoethanones." Arabian Journal of Chemistry 12, no. 8 (2019): 2882–96. http://dx.doi.org/10.1016/j.arabjc.2015.06.010.

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26

Shadrikova, V. A., E. V. Golovin, E. A. Kuznetsova, M. Yu Rostova, and Yu N. Klimochkin. "Synthesis of substituted 1-[2-(adamantan-1-yl)ethyl]piperidines." Russian Journal of Organic Chemistry 52, no. 10 (2016): 1452–62. http://dx.doi.org/10.1134/s1070428016100146.

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27

Zagidullin, A. A., A. V. Zorin, and V. V. Zorin. "Optimized synthesis of 2-substituted 1-halocyclopropane-1-carboxylic acids." Russian Journal of General Chemistry 86, no. 10 (2016): 2307–11. http://dx.doi.org/10.1134/s1070363216100108.

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28

Madre, M. A., R. A. Zhuk, and M. Yu Lidak. "Purinenucleoside analogs. 2. 9-(1-Alkoxyethyl-1)-6-substituted purines." Chemistry of Heterocyclic Compounds 22, no. 3 (1986): 331–34. http://dx.doi.org/10.1007/bf00515005.

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29

Okawara, Tadashi, Shuji Ehara, Shigenori Matsumoto, Yoshinari Okamoto, and Mitsuru Furukawa. "The 2 : 2 adducts from glutaraldehyde and 1-substituted ethylenediamines." Journal of the Chemical Society, Perkin Transactions 1, no. 7 (1990): 2160. http://dx.doi.org/10.1039/p19900002160.

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30

Štetinová, Jarmila, Rudolf Kada, Ján Leško, Lubomír Zalibera, Dušan Ilavský, and Alexander Bartovič. "Synthesis and Properties of Substituted 1-(2-Benzothiazolyl)-2-pyridones." Collection of Czechoslovak Chemical Communications 60, no. 6 (1995): 999–1008. http://dx.doi.org/10.1135/cccc19950999.

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The studied 1-(2-benzothiazolyl)-2-pyridones Va-Vf were prepared from N-(2-benzothiazolyl)cyanoacetamide (II) which on reaction with 4-substituted benzaldehydes afforded 3-aryl-N-(2-benzothiazolyl)-2-cyano-2-propenamides IVa-IVg. Compounds IVa-IVf were cyclized with malonodinitrile in the presence of piperidine to give the corresponding pyridones Va-Vf.
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31

Okonogi, Tsuneo, Seiji Shibahara, Yasushi Murai, Sigeharu Inouye, Shinichi Kondo, and Burton G. Christensen. "Novel 2-Methyl-1-oxacephalosporins 2. Synthesis of 3-Substituted 2-Methyl-1-oxacephem Nucleus." HETEROCYCLES 31, no. 5 (1990): 797. http://dx.doi.org/10.3987/com-90-5345.

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32

Abe, Noritaka, Tomoyuki Ariyoshi, Satomi Watarai, et al. "Synthesis of [Poly(2-pyridyl)-Substituted]-1-azaazulenes." HETEROCYCLES 77, no. 1 (2009): 565. http://dx.doi.org/10.3987/com-08-s(f)8.

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33

Köysal, Yavuz, Şamil Işık, Gülay Şahin, and Erhan Palaska. "TwoN-substituted 3,5-diphenyl-2-pyrazoline-1-thiocarboxamides." Acta Crystallographica Section C Crystal Structure Communications 61, no. 9 (2005): o542—o544. http://dx.doi.org/10.1107/s0108270105023255.

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34

Dunkerton, Lois V., Nancy K. Adair, Jack M. Euske, Kevin T. Brady, and Paul D. Robinson. "Regioselective synthesis of substituted 1-thiohex-2-enopyranosides." Journal of Organic Chemistry 53, no. 4 (1988): 845–50. http://dx.doi.org/10.1021/jo00239a030.

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35

Kaluz, Štefan, and Štefan Toma. "Preparation of 1’- and 2-substituted ferrocenylalanine derivatives." Collection of Czechoslovak Chemical Communications 53, no. 3 (1988): 638–42. http://dx.doi.org/10.1135/cccc19880638.

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Synthesis of N-formyl derivatives of racemic 1,1’-ferrocenedialanine, 1,2-ferrocenedialanine, and 1’-carboxyferrocenylalanine is described. The synthesis started from 1,1’-, 1,2-bis(hydroxymethyl)ferrocene, and methyl 1’-(hydroxymethyl)ferrocenecarboxylate, respectively.
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36

Miyamoto, K., K. Fujimori, J.-I. Hirano, and H. Ohta. "Microbial kinetic resolution of 2-substituted-1-propanol." Biocatalysis and Biotransformation 27, no. 1 (2009): 66–70. http://dx.doi.org/10.1080/10242420802393352.

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37

Dayam, Raveendra, Laith Q. Al-Mawsawi, and Nouri Neamati. "Substituted 2-pyrrolinone inhibitors of HIV-1 integrase." Bioorganic & Medicinal Chemistry Letters 17, no. 22 (2007): 6155–59. http://dx.doi.org/10.1016/j.bmcl.2007.09.061.

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38

Kitayama, Tatsuki, Anne Buyle Padias, and H. K. Hall. "On the polymerization of 1-substituted 2-azabutadienes." Polymer Bulletin 17, no. 5 (1987): 417–22. http://dx.doi.org/10.1007/bf00255613.

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39

Minnaard, A., B. Feringa, T. Hartog, A. Rudolph, and B. Maciá. "Enantioselective Synthesis oftrans-1-Alkyl-2-Substituted Cyclopropanes." Synfacts 2011, no. 01 (2010): 0057. http://dx.doi.org/10.1055/s-0030-1259163.

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40

Memarian, Hamid Reza, Masoud Nasr-Esfahani, Roland Boese, and Dietrich Döpp. "Photoaddition of 2-Morpholinoacrylonitrile to Substituted 1-Acetonaphthones." Liebigs Annalen 1997, no. 5 (1997): 1023–27. http://dx.doi.org/10.1002/jlac.199719970535.

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41

Wenzel, Thomas, and Frank Seela. "Synthesis of 6-Substituted 1-Deazapurine 2?-Deoxyribonucleosides." Helvetica Chimica Acta 79, no. 1 (1996): 169–78. http://dx.doi.org/10.1002/hlca.19960790117.

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42

Victory, Pedro, Angel Alvarez-Larena, Carlos Beti, Joséa I. Borrell, Xavier Batllori, and Carlos Córdoba. "Trioxypentafulvenes, 2 synthesis of 1-substituted 2,3,6-trioxypentafulvenes." Chemische Berichte 124, no. 1 (1991): 207–12. http://dx.doi.org/10.1002/cber.19911240131.

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43

Pandey, G., A. Krishna, and U. T. Bhalerao. "A one step synthesis of 2-substituted benzofurans from 2-aryl-1-substituted ethane-1-ones by photoinduced set reactions." Tetrahedron Letters 30, no. 14 (1989): 1867–70. http://dx.doi.org/10.1016/s0040-4039(00)99601-1.

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44

RAKESH, KUMAR, GIRl S., and NIZAMUDDIN. "Synthesis of some 1-[5' (Substituted-phenoxymethyl)- 1', 3',4'-thiadiazol-2'-yl]-4-substituted-2-azetidinones as Potential Fungicides." Journal of Indian Chemical Society Vol. 65, Aug 1988 (1988): 571–73. https://doi.org/10.5281/zenodo.6043518.

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Chemistry Department, University of Gorakhpur, Gorakhpur-273 009 <em>Manuscript received 22 February 1988, accepted 28 May 1988</em> Several 1-(5<em>&#39;</em>-substituted-phenyl-1<em>&#39;</em>,3<em>&#39;</em>,4<em>&#39;</em>-thiadiazol-2<em><sup>&#39;</sup></em>-yl)-3-chloro-4-substituted-2- azetidinones have been synthesised by the annulation of acid chlorides on anils using Et, N, and their antifungal activities have been reported. Based on screening data attempt has been made to throw light on structure-activity relationship
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45

Nikonov, I. L., D. S. Kopchuk, A. F. Khasanov, et al. "Two mutually complementary synthetic approaches towards 3-substituted 3,4-disubstituted and 1-(2-pyridyl)-substituted isoquinolines synthetic approaches towards 3-substituted 3,4-disubstituted and 1-(2-pyridyl)-substituted isoquinolines." Chimica Techno Acta 5, no. 3 (2018): 150–52. http://dx.doi.org/10.15826/chimtech.2018.5.3.04.

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46

Kobayashi, Kazuhiro, Shuhei Fukamachi, Seiki Fujita, Kazuya Murahashi та Hisatoshi Konishi. "Synthesis of 3-Substituted 1-Thioacyl- and 1-Thiocarbamoylindoles from α-Substituted 2-Isocyanato-β-methoxystyrenes". Synthesis 2010, № 17 (2010): 2985–89. http://dx.doi.org/10.1055/s-0030-1258177.

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47

SUSHMA, SAXENA, BHALLA M., VERMA M., K. SAXENA A., and SHANKER K. "New Quinazolone Congeners." Journal of Indian Chemical Society Vol. 68, Mar 1991 (1991): 142–43. https://doi.org/10.5281/zenodo.5955423.

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Department of Pharmacology and Therapeutics, Sing George&#39;s Medical College, Lucknow-226 003 <em>Manuscript received 5 October 1990, revised 11 February 1991,&nbsp; accepted 7 March 1991</em> 6, 8- Substituted - 2- ( 2- phenyletheny1)-3.(1-methy1-2-phenylethyl)- 4 ( 3<em>H</em>)-quina&shy;zolinones(2a - d) and 6,8-substituted-2-bromomethy1-3-(1-methyl-2-phenylethyl)-4(3<em>H</em>)- quinazolinones (5a-d) were synthesised from 6,8-substituted-7.-meth)1-3-(1-methyl&shy;h-phenylethyl)-4(3<em>H</em>)-quinazolinones (1). Compounds 2 were further brominated and treated with secondary amines to yie
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48

Ishmaeva, E. A., A. A. Gazizova, Ya A. Vereshchagina, et al. "Conformational analysis of 2-substituted 1-nitro-and 1-bromo-1-nitroethenes." Russian Journal of General Chemistry 77, no. 5 (2007): 894–98. http://dx.doi.org/10.1134/s1070363207050131.

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49

Dauben, William G., Vincent P. Rocco, and Gideon Shapiro. "Intramolecular [2 + 2] photocycloaddition of 4-substituted cyclopent-2-en-1-ones." Journal of Organic Chemistry 50, no. 17 (1985): 3155–60. http://dx.doi.org/10.1021/jo00217a027.

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50

Barlin, GB. "Heterocyclic Amplifiers of Phleomycin. VIII. Mono- Bis-(5'-substituted 1',3',4'-thiadiazol-2'-yl)pyridines and Mono(5'-substituted 1',3',4'-thiadiazol-2'-ylmethyl)pyridines." Australian Journal of Chemistry 38, no. 10 (1985): 1491. http://dx.doi.org/10.1071/ch9851491.

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A series of mono- and bis -(5′-substituted 1′,3′,4′-thiadiazol-2′- yl )pyridines with strongly basic side chains, e.g., 3,5-bis[5′(2′-N,N- dimethylaminoethylthio )-1′,3′,4′-thiadiazol-2′-yl]pyridine (1), and (5?-substituted 1′,3′,4′-thiadiazol-2′-ylmethyl)pyridines have been prepared for evaluation as amplifiers of phleomycin. Five of the six bis (5′-substituted 1′,3′,4′-thiadiazol-2′-yl)pyridines were themselves antibacterial under the test conditions, but compound (1) and the mono(5′-substituted 1′,3′,4′-thiadiazol-2′-yl)-pyridines and -methylpyridines displayed moderate two-to-three-star ac
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