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Relevant bibliographies by topics / 21-Hydroxylase Immune Response

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Academic literature on the topic '21-Hydroxylase Immune Response'

Author: Grafiati

Published: 5 June 2025

Last updated: 1 August 2025

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Journal articles on the topic "21-Hydroxylase Immune Response"

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Gerritsen, W. R., A. J. van den Eertwegh, T. D. de Gruijl, et al. "Biochemical and immunologic correlates of clinical response in a combination trial of the GM-CSF-gene transduced allogeneic prostate cancer immunotherapy and ipilimumab in patients with metastatic hormone-refractory prostate cancer (mHRPC)." Journal of Clinical Oncology 25, no. 18_suppl (2007): 5120. http://dx.doi.org/10.1200/jco.2007.25.18_suppl.5120.

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5120 Background: A Phase 1 trial is underway to study the GM-CSF-secreting immunotherapy for prostate cancer (GVAX immunotherapy [GVAX IT]) and ipilimumab (ipi) in mHRPC patients (pts). Methods: Twelve pts were treated for 24 weeks (wks) with bi-weekly intradermal injections of GVAX IT and monthly Ipi. Pts were enrolled in cohorts of 3; each cohort received an escalating dose of ipi: 0.3, 1, 3 or 5 mg/kg. Results: Median follow-up is 15.0 months. All pts had GVAX IT injection site reactions. Five of six pts at the higher ipi doses (3 and 5 mg/kg) developed Grade 2 or 3 immune-related endocrino

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Lee, Hyun-ju, Hyun-Jung Park, Angela Starkweather, Kyungeh An, and Insop Shim. "Decreased Interleukin-4 Release from the Neurons of the Locus Coeruleus in Response to Immobilization Stress." Mediators of Inflammation 2016 (2016): 1–8. http://dx.doi.org/10.1155/2016/3501905.

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It has been demonstrated that immobilization (IMO) stress affects neuroimmune systems followed by alterations of physiology and behavior. Interleukin-4 (IL-4), an anti-inflammatory cytokine, is known to regulate inflammation caused by immune challenge but the effect of IMO on modulation of IL-4 expression in the brain has not been assessed yet. Here, it was demonstrated that IL-4 was produced by noradrenergic neurons in the locus coeruleus (LC) of the brain and release of IL-4 was reduced in response to IMO. It was observed that IMO groups were more anxious than nontreated groups. Acute IMO (2

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Vergne-Santiago, Norma, Ernesto Jos E. Sola Sanchez, and Michelle Marie Mangual Garcia. "Immune Check Point Inhibitors Triggering Non Autoimmune Polyendocrinopathy." Journal of the Endocrine Society 5, Supplement_1 (2021): A136—A137. http://dx.doi.org/10.1210/jendso/bvab048.275.

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Abstract The superlative therapeutic response of cancer immunotherapy is activation of the immune system against cancer cells. Currently, one of the most considered immune system enhancer are the immunomodulatory antibodies well known as checkpoint inhibitor therapy. Among this type of treatment, programed cell death-1 receptor blocker, is one of the most sought-after therapies on demand now a day. Notwithstanding the important clinical benefits of this therapeutic modality, serial autoimmune adverse effects and variety of atypical presentations of life-threatening endocrinopathies are expecte

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Ghosh, Riya, Garima Joshi, Nishith M. Shrimali та ін. "Tibetan PHD2D4E;C127S variant protects from viral diseases in hypoxia, but predispose to infections in normoxia via HIFα:IFN axis". PLOS Pathogens 21, № 6 (2025): e1013296. https://doi.org/10.1371/journal.ppat.1013296.

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We previously reported that Tibetan-specific variant of prolyl-hydroxylase-2 (PHD2)D4E;C127S protects highlanders from hypoxia-triggered pathologies by destabilizing hypoxia-inducible factor (HIF)-1α. Others have reported that stabilized HIF1α negatively regulates interferon (IFN)-regulating factor (IRF)-3 under hypoxia. We examined the role of PHD2D4E;C127S variant in IFN synthesis in immune cells during viral infections. Primary monocytes and cells engineered to express the PHD2D4E;C127S variant displayed protection against dengue virus (DENV)-2 infection by suppressing HIF1α, in turn promot

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5

Witchel, S. F. "21-Hydroxylase Heterozygotism and Immune Regulation--Authors' Responsed." Journal of Clinical Endocrinology & Metabolism 82, no. 12 (1997): 4276. http://dx.doi.org/10.1210/jc.82.12.4276.

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6

Witchel, Selma F., Peter A. Lee, Makiko Suda-Hartman, Massimo Trucco, and Eric P. Hoffman. "21-Hydroxylase Heterozygotism and Immune Regulation—Authors’ Responsed." Journal of Clinical Endocrinology & Metabolism 82, no. 12 (1997): 4276. http://dx.doi.org/10.1210/jcem.82.12.4466-4.

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7

Naha, Sowjanya, Joseph Theressa Nehu Parimi, Rajani Gundluru, John Chen Liu, Hasan Syed, and Timur Gusov. "Persistent Fatigue After Pregnancy: A Case Report." Journal of the Endocrine Society 5, Supplement_1 (2021): A147. http://dx.doi.org/10.1210/jendso/bvab048.297.

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Abstract Background: Pregnancy is characterized by physiologic immunosuppression and the postpartum period is often associated with rebound autoimmunity leading to unmasking of latent autoimmune disorders. Clinical Case: A thirty-one-year-old Caucasian female presented with generalized fatigue, myalgias and arthralgias that started three months after the birth of her first child. She was seen at a local hospital on multiple occasions and was treated symptomatically. She was noted to have orthostatic hypotension during these visits and was initiated on midodrine and fludrocortisone for presumed

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8

Guo, M., J. Lingjuan, G. Ruan, Z. Runing, G. Yiqun, and Y. Hong. "P0050 4-Octyl Itaconate Protects Against Colitis by Modulating Neutrophil Function and Enhancing Intestinal Epithelial Barrier Integrity." Journal of Crohn's and Colitis 19, Supplement_1 (2025): i403—i404. https://doi.org/10.1093/ecco-jcc/jjae190.0224.

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Abstract Background Inflammatory bowel disease (IBD) is a complex gastrointestinal condition marked by immune system dysfunction and intestinal barrier damage. The pathogenesis involves a mix of genetic, environmental, and immunological factors, with the potential for itaconic acid derivatives like 4-Octyl itaconate (4-OI) to modulate immune responses and offer therapeutic benefits. Methods The study utilized a mouse model of acute colitis induced by dextran sulfate sodium (DSS) to evaluate the effects of 4-OI. C57BL/6J mice were divided into control and treatment groups, with interventions in

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9

Suraj, Kumar Labh, GNV Gayathri Deevi, and Sindhu Thella. "Addison`s Disease: Introduction and the First Presentation of the Condition May be at the Autopsy." September 14, 2022. https://doi.org/10.26452/fjphs.v2i4.299.

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Addison’s disorder is a comparatively rare situation, and can have disastrous effects although not immediately identified but also adequately handled. Mostly the odious existence of cancer that has spread in such a slow throughout treatment through clients who aren't really acknowledged till the extremely severe cortisol disaster begins to develop. Getting better sub members of the team sensitivity of this entire affliction might very well improve matters just that clients who already have Addison’s disorder. That whole specific diagnostic anyway inflammatory conditions Addison

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Ma, Boyan, Fengshuo Zhang, Sayed Haidar Abbas Raza, et al. "Palm kernel meal regulates the expression of genes involved in the amino acid metabolism in the liver of Tibetan sheep." BMC Veterinary Research 20, no. 1 (2024). http://dx.doi.org/10.1186/s12917-024-04193-7.

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Abstract Background Palm kernel meal (PKM) is a by-product of oil palm kernel after oil extraction, which is widely used in animal feeds due to its high energy content. This study aimed to investigate the impact of supplementing Tibetan sheep with PKM on their hepatic phenotype, oxidative stress and immune response. A total of 120 Tibetan lambs (Initial weight = 12.37 ± 0.92 kg) were randomly assigned into four groups: control group (C group, 0% PKM diet), low group (L group, 15% PKM diet), middle group (M group, 18% PKM diet), and high group (H group, 21% PKM diet) on a dry matter basis. The

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Book chapters on the topic "21-Hydroxylase Immune Response"

1

Su, Ying, Ren-Shan Ge, and Hong Xie. "Steroidogenesis of Corticosteroids, Genetic Mutation, and Endocrine Disruption Leading to Adrenal Insufficiency." In Cortisol - Between Physiology and Pathology [Working Title]. IntechOpen, 2023. http://dx.doi.org/10.5772/intechopen.1003273.

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Steroidogenesis, the process by which steroids are synthesized, involves a complex cascade of enzymatic reactions that ultimately produce hormones, such as cortisol and aldosterone. Cortisol is a steroid hormone that plays a critical role in the regulation of various physiological processes, including metabolism, immune response, and stress response. Aldosterone is responsible for blood pressure and water balance. The biosynthesis of cortisol and aldosterone occurs primarily in the adrenal cortex and is processed by a series of enzymatic reactions that convert cholesterol into cortisol and ald

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