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Relevant bibliographies by topics / 25-Hydroxyvitamin D3 1-alpha-Hydroxylase – metabolism

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Academic literature on the topic '25-Hydroxyvitamin D3 1-alpha-Hydroxylase – metabolism'

Author: Grafiati

Published: 4 June 2021

Last updated: 1 February 2022

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Journal articles on the topic "25-Hydroxyvitamin D3 1-alpha-Hydroxylase – metabolism"

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Carpenter, T. O., D. L. Carnes, and C. S. Anast. "Effect of magnesium depletion on metabolism of 25-hydroxyvitamin D in rats." American Journal of Physiology-Endocrinology and Metabolism 253, no. 1 (1987): E106—E113. http://dx.doi.org/10.1152/ajpendo.1987.253.1.e106.

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Resistance to vitamin D in magnesium depletion has been observed in humans and in animal studies. Variable levels of 1,25-dihydroxyvitamin D [1,25(OH)2D] have been reported in patients with magnesium depletion, and studies of vitamin D metabolism in states of magnesium depletion have not yielded consistent results. We examined effects of magnesium deprivation on circulating 1,25(OH)2D levels before and after a loading dose of 25-hydroxyvitamin D3 [25(OH)D3], on in vivo conversion of small doses of radiolabeled 25(OH)D3 to 1,25(OH)2D3 in intact rats, and on in vitro 25-hydroxyvitamin D-1 alpha-

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Turner, R. T., J. S. Graves, and N. H. Bell. "Regulation of 25-hydroxyvitamin D3 metabolism in chick embryo." American Journal of Physiology-Endocrinology and Metabolism 252, no. 1 (1987): E38—E43. http://dx.doi.org/10.1152/ajpendo.1987.252.1.e38.

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We investigated the time course of the development of renal 25-hydroxyvitamin D-1-hydroxylase and 25-hydroxyvitamin D-24-hydroxylase in chick embryos grown in the presence and absence of the eggshell. In embryos with the eggshell, the specific activity (SA) of 25-hydroxyvitamin D-1-hydroxylase in kidney homogenates increased from 0.68 fmol X min-1 X mg protein-1 at 12 days of gestation to a peak of 2.55 +/- 0.50 fmol X min-1 X mg-1 protein-1 at 17 days. In contrast, the SA of 25-hydroxyvitamin D-24-hydroxylase decreased from 2.5 fmol X min-1 X mg protein-1 to 0.90 +/- 0.25 fmol X min-1 X mg pr

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Postlind, H., and K. Wikvall. "Purification of a cytochrome P-450 from pig kidney microsomes catalysing the 25-hydroxylation of vitamin D3." Biochemical Journal 253, no. 2 (1988): 549–52. http://dx.doi.org/10.1042/bj2530549.

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Cytochrome P-450 catalysing 25-hydroxylation of vitamin D3 was purified from pig kidney microsomes. The enzyme fraction contained 7 nmol of cytochrome P-450/mg of protein and showed only one protein band with an apparent Mr of 50,500 upon SDS/polyacrylamide-gel electrophoresis. The purified cytochrome P-450 catalysed 25-hydroxylation of vitamin D3 up to 1,000 times more efficiently, and 25-hydroxylation of 1 alpha-hydroxyvitamin D3 up to 4000 times more efficiently, than the microsomes. The cytochrome P-450 required microsomal NADPH-cytochrome P-450 reductase for catalytic activity. Mitochondr

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Yu, Wen-Xuan, Christina Chui-Wa Poon, Wayne Yuk-Wai Lee, and Man-Sau Wong. "Oleanolic Acid Modulates 25-Hydroxyvitamin D3 1-alpha-hydroxylase in Osteoblasts and Human Mesenchymal Stem Cells." Journal of the Endocrine Society 5, Supplement_1 (2021): A237. http://dx.doi.org/10.1210/jendso/bvab048.482.

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Abstract Objectives: 25-Hydroxyvitamin D3 1-alpha-hydroxylase (CYP27B1) catalyzes the hydroxylation of 25-hydroxyvitamin D3 (25(OH)D3) to 1alpha,25-dihydroxyvitamin D3 (1,25(OH)2D3), the bioactive form of vitamin D3. Our previous studies suggested that oleanolic acid (OA), a pentacyclic triterpenoid presents in many food and herbs, can improve circulating 1,25(OH)2D3 in ovariectomized (OVX) mice and increase CYP27B1 expression in human renal proximal tubular cells (HKC-8). However, the role of OA in regulating CYP27B1 in bone is far from clear. The present study is designed to study the effect

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Adams, J. S., and M. A. Gacad. "Characterization of 1 alpha-hydroxylation of vitamin D3 sterols by cultured alveolar macrophages from patients with sarcoidosis." Journal of Experimental Medicine 161, no. 4 (1985): 755–65. http://dx.doi.org/10.1084/jem.161.4.755.

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We investigated the 1 alpha-hydroxylation of vitamin D3 sterols by cultured pulmonary alveolar macrophages (PAM) from patients with sarcoidosis with or without clinically abnormal calcium homeostasis. Like the naturally occurring renal 1 alpha-hydroxylase, the PAM 1 alpha-hydroxylation reaction exhibited a high affinity for 25-hydroxyvitamin D3 (25-OH-D3) and a preference for substrates containing a 25-hydroxyl group in the side chain of the sterol. Unlike the renal enzyme, the PAM 1 alpha-hydroxylating mechanism was not accompanied by 24-hydroxylating activity, even after preincubation with 7

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Lee, Sang R., Mi-Young Park, Hyun Yang та ін. "5α-dihydrotestosterone reduces renal Cyp24a1 expression via suppression of progesterone receptor". Journal of Molecular Endocrinology 60, № 2 (2018): 159–70. http://dx.doi.org/10.1530/jme-17-0187.

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Androgens act in concert with vitamin D to influence reabsorption of calcium. However, it is unclear whether androgens directly regulate vitamin D homeostasis or control other cellular events that are related to vitamin D metabolism. To examine whether the expression of vitamin D-related genes in mouse kidney is driven by androgens or androgen-dependent effects, the androgen receptor and other sex steroid receptors were monitored in orchidectomized mice treated with 5α-dihydrotestosterone (DHT). Our results revealed that exposing orchidectomized mice to DHT inhibited the expression of progeste

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Vieth, R., K. McCarten, and K. H. Norwich. "Role of 25-hydroxyvitamin D3 dose in determining rat 1,25-dihydroxyvitamin D3 production." American Journal of Physiology-Endocrinology and Metabolism 258, no. 5 (1990): E780—E789. http://dx.doi.org/10.1152/ajpendo.1990.258.5.e780.

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To understand the relationships among 1) the dose of 25-hydroxyvitamin D [25(OH)D] in vivo, 2) the activity of 1-hydroxylase in renal mitochondria, and 3) the production of 1,25-dihydroxyvitamin D [1,25(OH)2D] in vivo, we gave rats different chronic or acute doses of 25-hydroxyvitamin D3 [25(OH)D3]. We followed the metabolism of intracardially administered [25-hydroxy-26,27-methyl-3H]cholecalciferol [25(OH)[3H]D3] for 24 h before killing by measuring extracts of serum by chromatography. Specific activity of 1-hydroxylase in kidney was measured at death. In rats given 0-2,000 pmol 25(OH)D3 chro

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Carpenter, T. O., and T. Shiratori. "Renal 25-hydroxyvitamin D-1 alpha-hydroxylase activity and mitochondrial phosphate transport in Hyp mice." American Journal of Physiology-Endocrinology and Metabolism 259, no. 6 (1990): E814—E821. http://dx.doi.org/10.1152/ajpendo.1990.259.6.e814.

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The Hyp mouse is a homologue of the X chromosome-linked human disease, familial hypophosphatemic rickets (FHR). In FHR, reduced renal tubular brush-border membrane transport of phosphate results in hypophosphatemia and rickets. Both humans with FHR and Hyp mice have abnormal regulation of 25-hydroxyvitamin D-1 alpha-hydroxylase (1 alpha-hydroxylase), a mitochondrial enzyme found in proximal renal tubular cell epithelia, the apparent site of defective brush-border membrane phosphate transport. No common pathophysiology for these defects has been demonstrated. We hypothesized that phosphate tran

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Carpenter, T. O., M. L. Pendrak, and C. S. Anast. "Metabolism of 25-hydroxyvitamin D in copper-laden rat: a model of Wilson's disease." American Journal of Physiology-Endocrinology and Metabolism 254, no. 2 (1988): E150—E154. http://dx.doi.org/10.1152/ajpendo.1988.254.2.e150.

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Wilson's disease results in excess tissue accumulation of copper and is often complicated by skeletal and mineral abnormalities. We investigated vitamin D metabolism in rats fed a copper-laden diet rendering hepatic copper content comparable with that found in Wilson's disease. Injection of 25-hydroxyvitamin D3 [25(OH)D3] resulted in reduced 1,25-dihydroxyvitamin D [1,25(OH)2D] levels in copper-intoxicated rats. In vitro 25(OH)D-1 alpha-hydroxylase activity was impaired in renal mitochondria from copper-intoxicated animals. Activity was also inhibited in mitochondria from controls when copper

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Lobaugh, B., A. Boass, G. E. Lester, and S. U. Toverud. "Regulation of serum 1,25-dihydroxyvitamin D3 in lactating rats." American Journal of Physiology-Endocrinology and Metabolism 259, no. 5 (1990): E665—E671. http://dx.doi.org/10.1152/ajpendo.1990.259.5.e665.

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To characterize further the mechanism(s) underlying the increased serum 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] concentration associated with lactation in the rat, we examined hormone biosynthesis [i.e., renal 25-hydroxyvitamin D-1 alpha-hydroxylase (1 alpha-hydroxylase) activity] and hormone disappearance in groups of lactating Holtzman rats and age- and sex-matched nonlactating controls. 1 alpha-Hydroxylase activity was significantly greater in kidneys from lactating rats (4.0 +/- 0.42 fmol.mg-1.min-1) on a basal diet than in those from nonmated females (1.4 +/- 0.08 fmol.mg-1.min-1), an incr

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Dissertations / Theses on the topic "25-Hydroxyvitamin D3 1-alpha-Hydroxylase – metabolism"

1

Naja, Roy Pascal. "The role of Vitamin D metabolic enzymes in bone development and repair /." Thesis, McGill University, 2008. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=115860.

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The CYP27B1 enzyme that synthesizes 1alpha,25-(OH) 2D, is expressed in chondrocytes, suggesting that local production of 1alpha,25-(OH)2D could play an autocrine or paracrine role in the differentiation of these cells. To test this hypothesis, we have engineered mutant mice that do not express the Cyp27b1 gene in chondrocytes. This led to increased width of the hypertrophic zone of the growth plate at E15.5, increased bone mass in neonatal long bones, and increased expression of the chondrocytic differentiation markers Indian Hedgehog and PTH/PTHrP receptor. VEGF mRNA levels were decreased, ac

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Dong, Linda M. "Genetic variations in calcium and vitamin D related genes and colon cancer risk /." Thesis, Connect to this title online; UW restricted, 2007. http://hdl.handle.net/1773/10926.

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3

"Gas chromatography-mass fragmentographic analysis of serum 1[alpha], 25-dihydroxyvitamin D3." Chinese University of Hong Kong, 1991. http://library.cuhk.edu.hk/record=b5886886.

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by Priscilla Miu-kuen Poon.<br>Thesis (M.Phil.)--Chinese University of Hong Kong, 1991.<br>Includes bibliographical references.<br>ACKNOWLEDGEMENT --- p.1<br>ABSTRACT --- p.2<br>CONTENTS<br>Chapter 1. --- INTRODUCTION --- p.4<br>Chapter 1.1 --- Discovery of vitamin D<br>Chapter 1.2 --- Bioavailability of vitamin D and its metabolites<br>Chapter 1.3 --- Metabolism of vitamin D and its metabolites<br>Chapter 1.4 --- Mode of action of vitamin D<br>Chapter 1.5 --- Vitamin D-related diseases<br>Chapter 2. --- METHODS OF MEASURING VITAMIN D AND ITS METABOLITES --- p.32<br>Chapter 2.1 --- Deprote

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