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Journal articles on the topic '278.19.25 (043.2)'

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Published: 30 May 2022

Last updated: 31 July 2025

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1

Nurbaeva, K., T. Reshetnyak, F. Cheldieva, M. Cherkasova, E. Samarkina, and A. Lila. "AB0116 NEW INFLAMMATORY MARKERS IN SYSTEMIC LUPUS ERYTHEMATOSUS AND ANTIPHOSPHOLIPID SYNDROME." Annals of the Rheumatic Diseases 81, Suppl 1 (2022): 1188.1–1189. http://dx.doi.org/10.1136/annrheumdis-2022-eular.1331.

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BackgroundThromboinflammation is a pathological process that is associated with uncontrolled inflammation, leading to hypercoagulability and thrombotic complications. Systemic lupus erythematosus (SLE) and antiphospholipid syndrome (APS) are prototypical chronic thromboinflammatory diseases. Neutrophils are important cells in the development of systemic inflammation and thrombosis. Neutrophil reactivity (NEUT-RI), neutrophil granularity (NEUT-GI), immature granulocytes (IG), and neutrophil-to-lymphocyte ratio (NLR) are considered as inflammatory markers.ObjectivesTo determine the role of param

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Gupta, Sameer, Jeetendra Paryani, Arun Chaturvedi, Vijay Kumar, and Naseem Akhtar. "Triple negative breast cancer: An Indian problem— Experience from a tertiary care oncology centre." Journal of Clinical Oncology 35, no. 15_suppl (2017): e12583-e12583. http://dx.doi.org/10.1200/jco.2017.35.15_suppl.e12583.

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e12583 Background: Breast cancer is a heterogeneous disease with distinct biological subtypes as determined by gene expression profiling studies. Breast cancer is most common cancer in Indian females and is believed to be biologically different from west, notably in terms of high prevalence of Triple negative subtype (TNBC). Reliable data on clinical and epidemiological profile of TNBC in Indian population is scarce. Aim of this study was to analyze the epidemiological and clinical profile of TNBCs Methods: Data of 355 patients of breast cancer registered in our department between 2013 and 201

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Sakamoto, Tomohiro, Taichi Matsubara, Takayuki Takahama, et al. "Biomarker Testing in Patients With Unresectable Advanced or Recurrent Non–Small Cell Lung Cancer." JAMA Network Open 6, no. 12 (2023): e2347700. http://dx.doi.org/10.1001/jamanetworkopen.2023.47700.

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ImportanceBiomarker testing for driver mutations is essential for selecting appropriate non–small cell lung cancer (NSCLC) treatment but is insufficient.ObjectiveTo investigate the status of biomarker testing and drug therapy for NSCLC in Japan for identifying problems in treatment.Design, Setting, and ParticipantsThe REVEAL cohort study included retrospective data collection and prospective follow-up from 29 institutions across Japan. Of 1500 patients diagnosed with advanced or recurrent NSCLC between January 1 and March 18, 2021, 1479 were eligible. Cases recognized at the wrong clinical sta

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Rodriguez, Karla Baez, Nicole Torres Rivera, Janevi Rebernigg, et al. "PSUN146 Diabetes, Obesity, and Diabetes-Obesity Overlap Syndrome in Hospitalized Adult COVID-19 Patients: Comorbidity Dose is The Thing!" Journal of the Endocrine Society 6, Supplement_1 (2022): A365. http://dx.doi.org/10.1210/jendso/bvac150.758.

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Abstract Excess risk for mortality in hospitalized adults with COVID-19 has been linked to extant chronic conditions, especially obesity (Obes), diabetes (DM) or combination (ObesDM). We investigated dose-response interactions between Elixhauser Comorbidity Index (ECI) and comorbidity ensembles including Obes, DM, ObesDM or Control. Presentation demographics, putative COVID-19 severity markers, and administrative data including ICD-10 codes to measure ECI (AHRQ, v2022.1, 0-38 categories) were extracted under IRB exemption from electronic medical records. Youden's J statistic identified ECI35 p

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Waddington, J. M., and P. McNeil. "Peat oxidation in an abandoned cutover peatland." Canadian Journal of Soil Science 82, no. 3 (2002): 279–86. http://dx.doi.org/10.4141/s01-043.

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Drained and cutover peatlands represent a persistent source of atmospheric CO2. Contemporary, intermediate, and long-term rates of peat oxidation were measured in an abandoned cutover peatland to estimate the mass of lost in order to determine if the oxidation rate has changed with time since abandonment. Contemporary rates were measured six times per week at 25 locations within the peatland using a portable infrared gas analyser and an enclosure system. Mean daily peat oxidation was 7.7 g CO2 m-2 d-1 or 4.8 mm yr-1. Intermediate (2-13 yr) oxidation rates were estimated using dendrochronologic

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Gupta, Divya Myadam, Vikashini Savadamuthu, FeiFei Qin, et al. "Feasibility of large scale distress screening at an academic center and associated network sites using an adapted patient-reported outcome instrument and reflexive suicide screening." Journal of Clinical Oncology 40, no. 28_suppl (2022): 278. http://dx.doi.org/10.1200/jco.2022.40.28_suppl.278.

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278 Background: Regular distress screening of patients with cancer is mandated by cancer care guidelines, with 25-50% of patients with cancer experiencing some level of distress. The COVID-19 pandemic amplified symptoms of distress and shifted oncologic care delivery towards telemedicine. In light of challenges faced with implementation of such screening, especially during this pandemic, we sought to assess the feasibility of implementing patient-focused distress screening at a large academic cancer center and its associated network sites. Methods: We designed a modified distress screening too

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R., N. Yadava, and Jain Parol. "A new flavone glycoside from the seeds of Cassia sophera Linn." Journal of Indian Chemical Society Vol. 83, Nov 2006 (2006): 1175–78. https://doi.org/10.5281/zenodo.5833009.

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Natural Products Laboratory, Department of Chemistry, Dr. H. S. Gour University, Sagar 470 003, Madhya Pradesh, India <em>E-mail </em>: rnyadava@rediffmail.com <em>Manuscript received 25 August 2005, revised 19 June 2006, accepted 25 August 2006</em> A new flavone glycoside A, m.p. 248-251 ºC, C<sub>33</sub>H<sub>40</sub>O<sub>2</sub>, [M]<sup>+</sup> 756 (FABMS) has been isolated from methanol soluble fraction of defatted seeds of Cassia sophera Linn. alongwith a known compound B, 5-hydroxy-7,4',5' trimethoxyisoflavone- 3' -<em>O-</em>β-D-glucopyranoside. Compound A was

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Calderón-Goercke, M., J. J. Gaitán-Valdizán, R. Fernández-Ramón, L. Sánchez-Bilbao, R. Demetrio-Pablo, and R. Blanco. "SAT0512 OCULAR INVOLVEMENT AND TREATMENT IN SARCOIDOSIS. STUDY OF 41 PATIENTS OF A SERIES OF 383 PATIENTS FROM A SINGLE UNIVERSITY HOSPITAL." Annals of the Rheumatic Diseases 79, Suppl 1 (2020): 1212.2–1212. http://dx.doi.org/10.1136/annrheumdis-2020-eular.3757.

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Background:The eye is a common and potential severe complication of sarcoidosis. Topical and systemic corticosteroids are the first-line treatment. Conventional and biological immunosuppressants (IS) are frequently needed(1-5).Objectives:To assess the frequency, clinical and treatment of ocular involvement of sarcoidosis.Methods:Study of a large cohort (n=383) of systemic sarcoidosis from a single university hospital. All consecutive patients diagnosed with sarcoidosis from January 1,1999 to January 1,2019 according the ATS/ERS/WASOG criteria(Eur Respir J 1999;14:735–737) were included.Results

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Bowmaker, Graham A., Effendy, Robert D. Hart, John D. Kildea, and Allan H. White. "Lewis-Base Adducts of Group 11 Metal(I) Compounds. LXXIII Synthesis, Spectroscopy and Structural Systematics of New 1 : 1 'Cubane' Tetramers of Copper(I) and Silver(I) Halides with Triphenylarsine." Australian Journal of Chemistry 50, no. 6 (1997): 653. http://dx.doi.org/10.1071/c96039.

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Syntheses and room-temperature single-crystal X-ray structural characterization of a number of 1 : 1 ‘cube tetramer’ adducts of copper(I) and silver(I) halides, MX, with triphenylarsine, AsPh3, are recorded, being [XM(AsPh3)]4. The CuBr adduct, obtained unsolvated from toluene, orthorhombic Pbcn, a 17·844(5), b 20·778(8), c 18·430(4) Å, Z = 4 tetramers, conventional R on |F| 0·058 for No 1309 independent ‘observed’ reflctions (I > 3σ(I)), is isomorphous with previously recorded [ClAg(PPh3)]4, the tetramer having crystallographically imposed 2 symmetry. The CuI adduct, previously recorded as

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Iovoli, Austin J., Lauren Turecki, Michelle L. Qiu, et al. "Severe Oral Mucositis After Intensity-Modulated Radiation Therapy for Head and Neck Cancer." JAMA Network Open 6, no. 10 (2023): e2337265. http://dx.doi.org/10.1001/jamanetworkopen.2023.37265.

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ImportanceOral mucositis (OM) is a common and debilitating adverse effect observed in patients with head and neck cancer (HNC) receiving radiation therapy (RT). Previous studies examining associations between OM and clinical outcomes were performed in the era of 3-dimensional conformal RT planning with low rates of concurrent chemotherapy, and thus may not reflect current practice.ObjectiveTo prospectively assess patient-reported OM and identify its associations with clinical outcomes and quality of life.Design, Setting, and ParticipantsThis cohort study performed at a single institution inclu

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Plesec, Thomas P., Angela Ruiz, James T. McMahon, and Richard A. Prayson. "Ultrastructural Abnormalities of Respiratory Cilia: A 25-Year Experience." Archives of Pathology & Laboratory Medicine 132, no. 11 (2008): 1786–91. http://dx.doi.org/10.5858/132.11.1786.

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Abstract Context.—Ciliary dyskinesia is a rare, but significant, cause of chronic respiratory infections, and transmission electron microscopy is a critical adjunct to making the diagnosis. Objective.—To investigate a single institution's experience with patients demonstrating abnormal ciliary ultrastructure. Design.—Retrospective clinicopathologic review of 278 bronchial or nasal turbinate brushings or biopsies from 1983 through 2007. Results.—There were 12 women and 9 men (mean age, 19.6 years; range, 1–54 years) with abnormal ciliary ultrastructure. Clinical history was unavailable in 3 pat

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Gangi, Alexandra, James Mirocha, Trista Leong, and Armando E. Giuliano. "Triple-negative breast cancer and likelihood of nodal metastates." Journal of Clinical Oncology 31, no. 26_suppl (2013): 50. http://dx.doi.org/10.1200/jco.2013.31.26_suppl.50.

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50 Background: Axillary lymph node metastases are a prognostic indicator for breast cancer. Studies suggest that breast cancer subtypes are associated with the presence of lymph node (LN) metastases. The purpose of this study was to determine if patients with triple negative breast cancer (TNBC) have a higher risk of LN metastases than those with non-TNBC. Methods: Prospective database review identified 2,967 female patients with invasive breast cancer treated with mastectomy or breast conserving surgery (BCS) between January 2000 and May 2012. Only patients who underwent sentinel node biopsy

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Minozzo, João Carlos, Rubens L. Ferreira Gusso, Edilene A. de Castro, Oscar Lago, and Vanete Thomaz Soccol. "Experimental bovine infection with Taenia saginata eggs: recovery rates and cysticerci location." Brazilian Archives of Biology and Technology 45, no. 4 (2002): 451–55. http://dx.doi.org/10.1590/s1516-89132002000600008.

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Studies were carried out on the recovery rate and cysticerci location in bovines experimentally infected with Taenia saginata eggs. Three calves of 6.5 months and one with 19 months of age were infected orally with 2 x 10(4) eggs of Taenia saginata. A fifth calf served as control. After 90 days of infection, the animals were slaughtered and organs and skeletal muscles were inspected using a slicing technique every 5 mm. From the four infected calves, 702 cysticerci were recovered, of which 570 (81.2%) were alive and 132 (18.8%) were degenerated. The recovery rate ranged from 0.01 to 1.43% with

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Nakayama, Y., R. Nakashima, T. Handa, et al. "POS1051 LUNG CLUSTERING ANALYSIS-BASED PHENOTYPES OF RHEUMATOID ARTHRITIS USING ARTIFICIAL INTELLIGENCE-BASED TECHNOLOGY FOR CHEST COMPUTED TOMOGRAPHY." Annals of the Rheumatic Diseases 82, Suppl 1 (2023): 843.1–844. http://dx.doi.org/10.1136/annrheumdis-2023-eular.2178.

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BackgroundLung involvement is a prevalent extraarticular manifestation of rheumatoid arthritis (RA) that remains a significant clinical challenge. Few studies have comprehensively quantified lung abnormalities of RA patients using artificial intelligence-based (AI) technology.ObjectivesThe aim of this study was to quantify lung lesions in RA patients and classify them based on their lung parameters.MethodsAn AI-based quantitative computed tomography (CT) image analysis software (AIQCT) was applied to high-resolution CT scans of RA patients in a cross-sectional manner. AIQCT automatically class

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Lucovnik, Miha, Mirjam Druskovic, Marijana Vidmar Simic, et al. "Perinatal outcomes in women with severe acute respiratory syndrome coronavirus 2 infection: comparison with contemporary and matched pre-COVID-19 controls." Journal of Perinatal Medicine 50, no. 3 (2021): 253–60. http://dx.doi.org/10.1515/jpm-2021-0313.

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Abstract Objectives To compare perinatal outcomes in women with vs. without severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Methods Perinatal outcomes in SARS-CoV-2 positive pregnant women who delivered at our institution between October 27th 2020 and January 31st 2021 were compared to SARS-CoV-2 negative pregnancies (contemporary controls) and historical 2019 controls matched by maternal age, pre-pregnancy body mass index and parity. Testing was performed based on symptoms or close contact at any time during pregnancy and as part of universal screening at hospital admi

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Krzywicka, Katarzyna, Anita van de Munckhof, Mayte Sánchez van Kammen, et al. "Age-Stratified Risk of Cerebral Venous Sinus Thrombosis After SARS-CoV-2 Vaccination." Neurology 98, no. 7 (2021): e759-e768. http://dx.doi.org/10.1212/wnl.0000000000013148.

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Background and ObjectivesCerebral venous sinus thrombosis (CVST) as a part of the thrombosis and thrombocytopenia syndrome is a rare adverse drug reaction of severe acute respiratory syndrome coronavirus disease 2 (SARS-CoV-2) vaccination. Estimated background rate of CVST with thrombocytopenia is 0.1 per million per month. We assessed the age-stratified risk of CVST with and without thrombocytopenia after SARS-CoV-2 vaccination.MethodsWe estimated the absolute risk of CVST with and without thrombocytopenia within 28 days of a first dose of 4 SARS-CoV-2 vaccinations using data from the Europea

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Fajar, Ibtesam-E., Hina Aslam, Nimra Ijaz, et al. "Assessment of The Immediate Side Effects of Covid-19 Vaccination Among The People of Pakistan." Pakistan Journal of Medical and Health Sciences 15, no. 10 (2021): 3076–79. http://dx.doi.org/10.53350/pjmhs2115103076.

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The Covid-19 pandemic has wreaked havoc throughout the world, with 150 million cases to date and over 3 million lives claimed worldwide Objectives: To assess the immediate side effects of Covid-19 vaccination among the people of Pakistan Study Design: Randomized, descriptive cross-sectional study Methodology: Present study was carried out using an online questionnaire by enrolling 17040 subjects. Inclusion/Exclusion criteria: All citizens of Pakistan over the age of 12, who were eligible for the COVID-19 vaccination were enrolled. Statistical analysis: Data was analyzed by SPSS software, versi

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Offer, N. W., M. Marsden, J. Dixon, B. K. Speake, and F. E. Thacker. "Effect of dietary fat supplements on levels of n-3 poly-unsaturated fatty acids,transacids and conjugated linoleic acid in bovine milk." Animal Science 69, no. 3 (1999): 613–25. http://dx.doi.org/10.1017/s135772980005147x.

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AbstractThe effects of three fat supplements on milk yield and composition were measured using 12 mid-lactation in-calf Hoistein-Friesian cows in a balanced incomplete change-over design over three periods each of 3 weeks. All cows received a basal diet consisting of 36 kg/day grass silage (dry matter (DM) 270 g/kg, metabolizable energy (ME) 11·6 MJ/kg DM) and 7 kg/day o f a concentrate mixture containing (g/kg) rolled barley (501), molassed sugar-beet pulp shreds (277), soya-bean meal (208) and a standard cow mineral supplement (14). Treatments were CON (control-no supplement); LIN and FISH (

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Ahn, Chul Woo, Namki Hong, Seunghyun Lee, Hye-Sun Park, Yumie Rhee, and Sungjae Shin. "ODP274 Shift work is associated with normal weight obesity in community-dwelling adults." Journal of the Endocrine Society 6, Supplement_1 (2022): A434—A435. http://dx.doi.org/10.1210/jendso/bvac150.903.

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Abstract Objective Shift working is known to be associated with metabolic syndrome and increased cardiovascular risk. In this study, we aimed to investigate whether shift work is associated with normal weight obesity (NWO), defined as normal weight with high body fat percentage. Method: From the national representative Korea National Health and Nutrition Examination Survey dataset (KNHANES 2008-2011), data of 3800 full-time workers with age≥ 19 years and body mass index (BMI)≤ 25 kg/m 2 were analyzed. In this study, we defined NWO was defined as BMI≤25 kg/m 2 and body fat (BF)percentage≥25% in

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Fallah, Parvaneh, Nasser Khleel Mulla, Raquel Aloyz, et al. "Can high Ki67 predict distant recurrence in early-stage breast cancer with low Oncotype Dx score?" Journal of Clinical Oncology 39, no. 15_suppl (2021): e12561-e12561. http://dx.doi.org/10.1200/jco.2021.39.15_suppl.e12561.

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e12561 Background: Ki-67 is a marker of proliferating cells. The recurrence score based on the 21-gene breast cancer assay also called Oncotype Dx provides prognostic and predictive information for recurrence in early stage breast cancer patients. We previously showed that there is a moderate correlation between Ki67 and oncotype Dx recurrence score. In this retrospective study, we aimed to examine whether high Ki67 could predict the distant recurrence in early stage breast cancer with low oncotype Dx scores ( < 25). Methods: This retrospective study included 278 consecutive cases of hormon

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Hamja, Amir, Nowsad Alam AKM, and Al Shahriar. "Marine Fish Drying in Major Drying Yards: An Explorative Study in the Bay of Bengal of Bangladesh." Sustainable Aquatic Research 4, no. 1 (2025): 23–40. https://doi.org/10.5281/zenodo.15188754.

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The study investigated detailed drying yard infrastructures, processing conditions, raw materials quality, spot quality defect point, packaging, storage, marketing, profit margin and production of commercially important marine fish species in major drying hubs of Cox's Bazar district. In Moheshkhali, Thakurtala (0.81 ha), Ghotibhanga (47.5 ha), and Sonadia yards (250 ha) identified 19±4, 71±3, and 250±11 active processors respectively. Shaporirdip (28.25±6.13 ha) and Shamlapur yards (21±5 ha) had 38±2 and 45±2 active processors respectively from

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Whittall, Ian R., Mark G. Humphrey, and David C. R. Hockless. "Structural Systematics of Metal Acetylide Complexes: X-Ray Studies of Some 'Extended-Chain' Gold σ-Acetylide Complexes." Australian Journal of Chemistry 50, no. 10 (1997): 991. http://dx.doi.org/10.1071/c97049.

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The structures of Au(4-C≡CC6H4XYC6H4-4′-NO2)(PPh3) (XY = (E )-CH=CH (1), (Z)-CH=CH (2), C≡C (3), N=CH (4)) have been determined by single-crystal X-ray diffraction analyses, refining by full-matrix least-squares analysis. For (1), crystals are triclinic, space group P-1, with a8·847(1), b 17·870(4), c 19·705(3) Å, α116·25(1), β 93·33(1), γ 92·64(2)˚, Z 4, 6747 unique reflections (703 parameters), converging at R 0·025 and Rw 0·029. For (2), crystals are monoclinic, space group P 21/a, with a 10·718(6), b 19·398(5), c14·469(3) Å, β 108·96(2)˚, Z 4, 3295 unique reflections (352 parameters), conv

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Shpagina, L. A., V. A. Kozik, I. S. Shpagin, et al. "Features of the course of acute coronary syndrome in medical workers who have undergone a new coronavirus infection." Ateroscleroz 19, no. 2 (2023): 107–14. http://dx.doi.org/10.52727/2078-256x-2023-19-2-107-114.

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Both in Russia and worldwide, morbidity and mortality from acute coronary syndrome (ACS) remain high. The emergence of a new coronavirus infection, the active participation of medical workers in its elimination, determined a new phenotype of patients, which determines the relevance of the problem and of a more detailed assessment of this cohort of patients. Aim of the study was to identify and determine the clinical and functional features, phenotype and endotype of the course of ACS in medical workers who have had a new coronavirus infection. Material and methods. An open cohort comparative s

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Sadhu, Justin S., Erik R. Dubberke, Robert Gatti, Steven M. Devine, and Victoria J. Fraser. "Clostridium Difficile-Associated Disease in Allogeneic Transplant Patients." Blood 104, no. 11 (2004): 5095. http://dx.doi.org/10.1182/blood.v104.11.5095.5095.

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Abstract Allogeneic transplant (allo) patients (pts) are at high risk for Clostridium difficile-associated disease (CDAD), yet there are few studies evaluating CDAD in allo pts. We carried out a retrospective chart review of all allo pts who had CDAD on a transplant (tx) unit between 8/01 and 7/03. 37 pts were identified who had CDAD during tx hospitalization (hosp) or after tx during the study period. 17 (46%) were admitted for initial tx, 13 (35%) for infection, and 7 (19%) for other reasons. 15 (40%) had acute leukemia, 6 (16%) lymphoma, 4 (11%) myelodisplastic syndrome, and 12 (32%) other

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Nepal, Bikash, Yogendra Singh, Prakash Sayami, and Gita Sayami. "An institutional review of tumour biology of breast cancer in young Nepalese women." Journal of Society of Surgeons of Nepal 18, no. 2 (2017): 16–19. http://dx.doi.org/10.3126/jssn.v18i2.18569.

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Introduction: Breast cancers in less than 40 years of age group usually present with aggressive biology and has poor prognosis. The aim of this study was to see clinic-pathological and hormone receptors of breast cancers in young women and compare with less than 40 year age group.Methods: Prospective analysis of 97 breast cancer in patients less than 40 years out of total 373 patients (26%) over a period of 8 years (2007 Jan to 2014 Dec) was carried out at the Department of Surgery, Tribhuvan University Teaching Hospital, Kathmandu, Nepal.Result: Among the young women diagnosed with breast can

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Bouwhuis, M., S. Suciu, W. Kruit, et al. "Prognostic value of autoantibodies (auto-AB) in melanoma patients (pts) in the EORTC 18952 trial of adjuvant interferon (IFN) compared to observation (obs)." Journal of Clinical Oncology 25, no. 18_suppl (2007): 8507. http://dx.doi.org/10.1200/jco.2007.25.18_suppl.8507.

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8507 Background: Appearance of auto-AB during IFN-adjuvant therapy is a prognostic factor in melanoma pts. We evaluated this in the EORTC 18952 trial including pts without IFN. Methods: Anti-cardiolipin (C) anti-thyreoglobulin (T) and anti- nuclear (N) AB levels of serial samples between 0 and 48 months (mt) were assessed centrally. Prognostic impact of CTN on relapse-free survival (RFS) was assessed by 3 methods: 1) usual Cox model (lead-time bias); 2) Cox Time dependent model using the latest positive CTN value; 3) Cox Time dependent model using the latest any CTN value. Results: In 278 pts

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Sarosa, Hadi, Udin Bahrudin, Ag Soemantri, Siti Fatimah Muis, Nur Arfian, and Ichiro Hisatome. "The Protective Effect of Azelnidipine for the Prevention of Heart Fibrosis Occurrence on Balb/c Mice with Iron Overload." Bangladesh Journal of Medical Science 19, no. 2 (2020): 223–28. http://dx.doi.org/10.3329/bjms.v19i2.44999.

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Background: Iron overload can cause DNA oxidation which increase TGF β1, type 1 fibrilarprotein and myocardium fibrosis. Myocardium fibrosis is the main cause of death on the state of iron overload. The iron influx towards the cell during iron overload is still unknown, some research suggested LTCC acts as iron influx. This research aims to investigate the role of azelnidipine as type L calcium channel blocker, lowering TGF β1, collagen and myocardium fibrosis. Method: The research subjects consisted of 25 male Balb-C mice(8 weeks, 30-40mg) divided into 5 groups. Group 1 (NaCl+S) 0,3 cc

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Lawal, Rialnat A., Natalie T. Deuitch, Erica Bresciani, et al. "Minority Patients in the NIH RUNX1-FPDMM Natural History Study Present Mostly with Large Deletions Affecting RUNX1." Blood 144, Supplement 1 (2024): 798. https://doi.org/10.1182/blood-2024-205563.

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Introduction Germline RUNX1 pathogenic variants lead to familial platelet disorder with associated myeloid malignancy (FPDMM). The autosomal dominant syndrome is rare and even less is known about minority patients with FPDMM. Patients present with varying degrees of bleeding symptoms that may not be clinically severe. However, a high lifetime incidence (35-45%) of developing hematologic malignancies (HM) makes early genetic diagnosis essential for patients and their families. Genetic testing can be a hindrance to diagnosis for minority patients, yet key to understanding the natural history of

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Strack, T. R., P. Poussier, E. B. Marliss, and A. M. Albisser. "Glucose turnover after a mixed meal in dogs: glucoregulation without change in arterial glycemia." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 266, no. 3 (1994): R889—R895. http://dx.doi.org/10.1152/ajpregu.1994.266.3.r889.

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Because the dog can respond to a mixed-meal challenge with little or no change in plasma glucose concentration, we used kinetic techniques to quantify the magnitude and duration of changes in glucoregulation. Glucose turnover was measured using [3-3H]glucose and [U-14C]glucose over two 19-h periods in healthy dogs, first during a fast (n = 6) and then throughout the postprandial state (n = 6) after a single mixed meal. Mean arterial glycemia remained constant in the fasted state (7.5 +/- 0.2 mM) and in the fed state (7.6 +/- 0.3 mM). Glucose appearance (Ra), however, increased slowly after the

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Mulyadi, Mulyadi. "Relationship on Education Level and Mother's Attitudes About Exclusive Association With Nutritional Status of Children." Eduvest - Journal of Universal Studies 1, no. 5 (2021): 373–82. http://dx.doi.org/10.36418/edv.v1i5.71.

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The magnitude of the problem of malnutrition in infants is a health problem for citizens in Indonesia. This research aims to analyze the relationship between knowledge and behavior of mothers about breastfeeding and exclusive breastfeeding with the nutritional status of infants aged 6- 24 months. This research used a quantitative observational analytic method with a cross sectional approach. The research population consisted of 98 mothers and toddlers aged 6- 24 months in Kayu Raja Village, Keritang Indragiri Hilir Subdistrict and 78 illustrations, using random sampling method. The questionnai

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O’Brien, Stephen G., François Guilhot, John M. Goldman, et al. "International Randomized Study of Interferon Versus STI571 (IRIS) 7-Year Follow-up: Sustained Survival, Low Rate of Transformation and Increased Rate of Major Molecular Response (MMR) in Patients (pts) with Newly Diagnosed Chronic Myeloid Leukemia in Chronic Phase (CMLCP) Treated with Imatinib (IM)." Blood 112, no. 11 (2008): 186. http://dx.doi.org/10.1182/blood.v112.11.186.186.

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Abstract Background: Based on results from the IRIS trial, IM is the standard of care for pts with newly diagnosed CML-CP. This report presents the 7 yr data update of IRIS to assess long term outcome, response rate, and safety in pts on primary IM therapy. Methods: 553 pts were randomly assigned to IM and evaluated for hematologic, cytogenetic and molecular responses, discontinuations/cross-over reasons, event-free survival (EFS), progression to accelerated-phase (AP) or blast crisis (BC) and OS. Events for EFS were defined as the first occurrence of any of the following during treatment: dea

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Li, Bing, Jinqin Liu, Shiqiang Qu, et al. "Colony-Forming Unit Cell (CFU-C) Assays in Myelodysplastic Syndrome." Blood 126, no. 23 (2015): 2874. http://dx.doi.org/10.1182/blood.v126.23.2874.2874.

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Abstract Introduction: The myelodysplastic syndromes (MDS) are a group of clonal diseases derived from hematopoietic stem cells (HSC). Colony-forming unit cell (CFU-C) assay is an effective method to study the number and the function of HSC in vitro. In this study, we focus on the characteristics and the prognostic value of CFU-C in patients with MDS. Patients and Method: CFU-C assays were performed according to the protocol of MethoCultTM H4435 Enriched (STEMCELL Technologies). A colony was defined as an aggregate of >40 cells. Clusters consisted of 4 to 40 cells. 560 consecutive newly-dia

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Yeh, Pat J.-F., and J. S. Famiglietti. "Regional Groundwater Evapotranspiration in Illinois." Journal of Hydrometeorology 10, no. 2 (2009): 464–78. http://dx.doi.org/10.1175/2008jhm1018.1.

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Abstract The role of shallow unconfined aquifers in supplying water for evapotranspiration (i.e., groundwater evaporation) is investigated in this paper. Recent results from regional land surface modeling have indicated that in shallow water table areas, a large portion of evapotranspiration comes directly from aquifers. However, little field evidence at the regional scale has been reported to support this finding. Using a comprehensive 19-yr (1984–2002) monthly hydrological dataset on soil moisture, water table depth, and streamflow in Illinois, regional recharge to and evaporation from groun

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Bektaş, M., S. Yüce, M. Ay, M. Uyar, M. Önder, and M. İ. Kiliç. "POS0555 HIGH DOSE INTRAVENOUS ANAKINRA TREATMENT IS SAFE AND EFFECTIVE IN SEVERE AND CRITICAL COVID-19 PATIENTS: A PROPENSITY SCORE MATCHED STUDY IN A SINGLE CENTER." Annals of the Rheumatic Diseases 82, Suppl 1 (2023): 544. http://dx.doi.org/10.1136/annrheumdis-2023-eular.339.

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BackgroundIn COVID-19 severe disease course such as need of intensive care unit (ICU) as well as development of mortality is mainly due to cytokine storm.ObjectivesIn this study, we aimed to evaluate the high dose intravenous anakinra treatment response and outcome in patients with severe and critical COVID-19 compared to standard of care.MethodsThis retrospective observational study was carried out at a tertiary referral center. The study population consisted of two groups as follows; the patients receiving high dose intravenous anakinra (anakinra group) between 01.09.2021 and 01.02.2022 and

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Wortelkamp, Fritz, Jingkwang Hwang, Kazuhiko Matsumoto, Rika Hagiwara, and Ingo Krossing. "Surface Modification of NaCrO₂ Positive Electrode Material for Sodium-Ion-Batteries." ECS Meeting Abstracts MA2023-02, no. 65 (2023): 3105. http://dx.doi.org/10.1149/ma2023-02653105mtgabs.

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Sodium-ion batteries are potential successors of lithium-ion batteries, due to the abundance of sodium resources, which leads to up to 30% cost reduction when the two systems are compared directly[1]. While the cost advantage is high the performance of sodium ion batteries still needs improvement if they are to replace their lithium counterparts in many areas. Stability and performance are big areas which need to be improved. The volatile (H2AlOtBu)2-precursor can be used to create a coating of HAlO on metal surfaces at 270°C from the gas phase via chemical vapor deposition. It has also been u

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O’Brien, Susan, Gary Schiller, Robert Kenneth Stuart, Diana Hudak, and Francis Giles. "Survival after Complete Response to Treatment with Laromustine (CLORETAZINE®) in Elderly Patients with De Novo Poor Risk Acute Myelogenous Leukemia (AML)." Blood 112, no. 11 (2008): 940. http://dx.doi.org/10.1182/blood.v112.11.940.940.

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Abstract Background: Treatment options for patients with AML are limited. Poor outcomes are associated with increasing age, decreasing performance status, unfavorable cytogenetics, and the presence of comorbid conditions. Elderly patients ³ 65 years with AML have a short survival (median 2.4 months) (Lang 2005), and for older patients who receive treatment, 1-year survival is 5–25% (Menzin 2002, Kantarjian 2006, Burnett 2007). CR/CRp is a desired outcome from induction treatment and a requisite for meaningful survival. Laromustine (Cloretazine) is a novel sulfonylhydrazine alkylating agent whi

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Yokoyama, Kota, Junichi Tsuchiya, and Ukihide Tateishi. "Comparison of [18F]FDG PET/CT and MRI for Treatment Response Assessment in Multiple Myeloma: A Meta-Analysis." Diagnostics 11, no. 4 (2021): 706. http://dx.doi.org/10.3390/diagnostics11040706.

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The present study was designed to assess the additional value of 2-deoxy-2[18F]fluoro-D-glucose ([18F]FDG) positron emission tomography/computed tomography (PET/CT) to magnetic resonance imaging (MRI) in the treatment response assessment of multiple myeloma (MM). We performed a meta-analysis of all available studies to compare the detectability of treatment response of [18F]FDG PET/CT and MRI in treated MM. We defined detecting a good therapeutic effect as positive, and residual disease as negative. We determined the sensitivities and specificities across studies, calculated the positive and n

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Gouda, Mohamed A., Blessie E. Nelson, Lars Buschhorn, Adam Wahida, and Vivek Subbiah. "Abstract 1173: Landscape of 4,506 pan-cancer samples harboring BRAFV600E mutations, and NTRK/RET Fusions from 137,401 adult patients with cancer: Clinical implications for tissue agnostic therapies." Cancer Research 83, no. 7_Supplement (2023): 1173. http://dx.doi.org/10.1158/1538-7445.am2023-1173.

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Abstract Background: Biomarker-driven trials have led to multiple FDA tissue-agnostic approvals. We aimed to explore the clinic-genomic landscape of alterations currently actionable by tissue-agnostic targeted therapies. Methods: We mined AACR Project GENIE to extract data about three molecular targets currently on the list of FDA tissue-agnostic approvals (RET fusions, NTRK fusions, and BRAFV600E mutations). Results: Among 137401 patients in GENIE database (153,834 samples), 4506 samples harbored BRAFV600E mutations (3%), 390 had NTRK fusions (0.3%), and 375 had RET fusions (0.2%) (Table 1).

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Begna, Kebede H., Naseema Gangat, Mithun V. Shah, et al. "Anthracycline Choices for Induction Chemotherapy Among 797 Consecutive Adult Patients with Acute Myeloid Leukemia: Daunorubicin-60 Vs Idarubicin-12 Vs Daunorubicin-90." Blood 138, Supplement 1 (2021): 1267. http://dx.doi.org/10.1182/blood-2021-147485.

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Abstract Objective : We describe the Mayo Clinic experience in 797 newly-diagnosed patients with acute myeloid leukemia (AML) serially treated with 7+3 induction chemotherapy that included 3 days of daunorubicin at a daily dose of 60 mg/m2 (dauno-60; n=239) or 90 mg/m2 (dauno-90; n=52), or idarubicin 12 mg/m2 (IDA-12; n=506). Our objective was to compare overall (OS) and relapse-free (RFS) survival outcome. Methods : Newly-diagnosed AML patients seen at our institution and received intensive induction chemotherapy were identified from the Mayo Clinic AML database. Treatment period spanned from

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Choquet, Sylvain, Adrien Grenier, Caroline Houillier, et al. "Very High Efficiency of ICE (Ifosfamide-Carboplatin-Etoposide) in Relapse/Refractory (R/R) Primary Central Nervous System (PCNSL) and Vitreo-Retinal (VRL) Non Hodgkin Lymphoma. a LOC Network Multicenter Retrospective Study on 58 Cases." Blood 126, no. 23 (2015): 1524. http://dx.doi.org/10.1182/blood.v126.23.1524.1524.

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Abstract Background: R/R PCNSL and VRL carry a very poor prognosis (i.e. 4,5 months, Jahnke, J neuro-oncol 2006)). Autologous stem-cell transplantation (ASCT) is effective in this setting but essentially if the disease is in good response (CR and PR). Since recent recommendations for first line treatment recommend high dose Mtx and AraC, new salvage chemotherapies must use other drugs. ICE regimen contain three drugs known to pass the blood-brain barrier and is validated in R/R systemic lymphoma but not in PCNSL/VRL. Methods: From June 2010 to May 2015, all relapse/refractory PCNSL and VRL alr

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Castellani, John W., Stephen R. Muza, Samuel N. Cheuvront, et al. "Effect of hypohydration and altitude exposure on aerobic exercise performance and acute mountain sickness." Journal of Applied Physiology 109, no. 6 (2010): 1792–800. http://dx.doi.org/10.1152/japplphysiol.00517.2010.

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Hypoxia often causes body water deficits (hypohydration, HYPO); however, the effects of HYPO on aerobic exercise performance and prevalence of acute mountain sickness (AMS) at high altitude (ALT) have not been reported. We hypothesized that 1) HYPO and ALT would each degrade aerobic performance relative to sea level (SL)-euhydrated (EUH) conditions, and combining HYPO and ALT would further degrade performance more than one stressor alone; and 2) HYPO would increase the prevalence and severity of AMS symptoms. Seven lowlander men (25 ± 7 yr old; 82 ± 11 kg; mean ± SD) completed four separate ex

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Sadoun, Eman, and May J. Reed. "Impaired Angiogenesis in Aging Is Associated with Alterations in Vessel Density, Matrix Composition, Inflammatory Response, and Growth Factor Expression." Journal of Histochemistry & Cytochemistry 51, no. 9 (2003): 1119–30. http://dx.doi.org/10.1177/002215540305100902.

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It is generally accepted that angiogenesis is delayed in aging. To define the effects of age on the neovascular response, polyvinyl alcohol sponges were implanted SC in young (6–8 months old, n = 11) and aged (23-25 months old, n = 13) mice and sampled at 14 and 19 days. Angiogenic invasion was significantly delayed in aged mice at 14d relative to young at 14d (% area of invasion 9.0 ± 3.7 vs 19.0 ± 5.6; p = 0.02). Although microvessel morphology and basement membrane composition were similar between the age groups, a significant decrease in capillary density was noted in aged tissues at 14d (

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Tang, Hanqi, Ruoxue Wu, Lu Yin, et al. "Escalating vs Fixed Energy Defibrillation in Out-of-Hospital Cardiac Arrest Ventricular Fibrillation." JAMA Network Open 8, no. 4 (2025): e257411. https://doi.org/10.1001/jamanetworkopen.2025.7411.

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ImportanceThere is limited evidence on whether higher-energy defibrillation is preferred in patients experiencing out-of-hospital cardiac arrest (OHCA) with shockable rhythms.ObjectiveTo investigate the optimal energy regimen for initial and subsequent defibrillation delivered by biphasic waveform automated external defibrillators (AEDs) in OHCA ventricular fibrillation (VF).Design, Setting, and ParticipantsThis cohort study was conducted in 48 cities across China, from 2017 to 2023, among 342 patients with OHCA who experienced at least 1 shock.ExposuresEscalating higher-energy (200-300-360 J)

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Cantù, M. G., A. Buda, G. Parma, et al. "Randomized Controlled Trial of Single-Agent Paclitaxel Versus Cyclophosphamide, Doxorubicin, and Cisplatin in Patients With Recurrent Ovarian Cancer Who Responded to First-Line Platinum-Based Regimens." Journal of Clinical Oncology 20, no. 5 (2002): 1232–37. http://dx.doi.org/10.1200/jco.2002.20.5.1232.

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PURPOSE: To assess the activity, efficacy, and tolerability of single-agent paclitaxel and a platinum-containing regimen in previously treated patients with recurrent ovarian cancer. PATIENTS AND METHODS: Patients who achieved complete remission with platinum-based regimens and whose disease recurred after a progression-free interval of more than 12 months were included in the study. Every 21 days, patients received paclitaxel 175 mg/m2 intravenously (IV) over 3 hours or cyclophosphamide 500 mg/m2, doxorubicin 50 mg/m2, and cisplatin 50 mg/m2 (CAP) IV. RESULTS: Between June 1992 and May 1995,

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Perlis, Roy H., Katherine Ognyanova, Ata Uslu, et al. "Trust in Physicians and Hospitals During the COVID-19 Pandemic in a 50-State Survey of US Adults." JAMA Network Open 7, no. 7 (2024): e2424984. http://dx.doi.org/10.1001/jamanetworkopen.2024.24984.

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ImportanceTrust in physicians and hospitals has been associated with achieving public health goals, but the increasing politicization of public health policies during the COVID-19 pandemic may have adversely affected such trust.ObjectiveTo characterize changes in US adults’ trust in physicians and hospitals over the course of the COVID-19 pandemic and the association between this trust and health-related behaviors.Design, Setting, and ParticipantsThis survey study uses data from 24 waves of a nonprobability internet survey conducted between April 1, 2020, and January 31, 2024, among 443 455 un

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Hunter, Natasha, Heather Anne Parsons, Leslie Cope, et al. "Circulating tumor DNA, pathologic response after neoadjuvant therapy, and survival: First results from TBCRC 040 (the PREDICT-DNA trial)." Journal of Clinical Oncology 43, no. 16_suppl (2025): 1009. https://doi.org/10.1200/jco.2025.43.16_suppl.1009.

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1009 Background: Patients with Stage II/III breast cancer that overexpresses the human epidermal growth factor-2 (HER2+) or is triple-negative (TNBC) generally receive upfront neoadjuvant therapy (NAT) before definitive surgery. Pathologic complete response (pCR) after NAT is associated with improved survival but a small proportion of patients remain at risk for recurrence. Circulating tumor DNA (ctDNA) in patients whose primary tumors have detectable mutations could improve the identification of patients who remain at risk after NAT. Methods: The Pathologic Response Evaluation and Detection I

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Patel, Priti, Mayra Telesca, and De-Hui Ku. "The Comparison of Fibrin Monomer (FM) Performance to Other Activation Markers (TAT, PF1.2 and DD)." Blood 118, no. 21 (2011): 5259. http://dx.doi.org/10.1182/blood.v118.21.5259.5259.

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Abstract Abstract 5259 In this study, we attempted to determine the performance of the soluble fibrin monomer complex (SFMC) test in comparison to known activation markers, such as prothrombin fragment 1.2 (PF1.2), thrombin antithrombin complex (TAT) and d-dimer (DD). We have used the STA(R)-Liatest FM and STA(R)-Liatest D-Di kits to measure the SFMC and d-dimer levels. A total of 25 patients were included in this study. The data and demographic information are shown in the table below. ID GENDER AGE FM TAT PF1.2 D-dimer 1 M 66 0.42 2.3 1988 0.05 2 F 31 27.93 >60.0 >12000 2.39 3 F 24 3.4

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Schenkel, Brad, Lorie Ellis, Stephanie Korrer, and Stacey DaCosta Byfield. "Real-world treatment patterns and health care resource utilization (HRU) among patients with chronic lymphocytic leukemia (CLL) by regimen." Journal of Clinical Oncology 34, no. 7_suppl (2016): 15. http://dx.doi.org/10.1200/jco.2016.34.7_suppl.15.

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15 Background: Few studies examine HRU of CLL, the most common hematologic malignancy in adults. This study describes HRU by the most common regimens among CLL patients (pts). Methods: A retrospective study using a large, national U.S. claims database from 1/2007-10/2013 was conducted. Adult CLL pts (≥2 claims for CLL) with ≥1 claim for systemic anticancer therapy (SACT) were identified; first SACT claim date was the index date. Pts had to have a CLL diagnosis ≤3 months (m) prior to the index date and be continuously enrolled (CE) in the health plan for 24m pre- and ≥6m post-index date. Pregna

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Kolodiy, A. A., and N. V. Gryazeva. "Evaluation of low doses effect of systemic isotretinoin in monotherapy and combination on qualitative and quantitative composition of microbiota in patients with acne." Medical alphabet, no. 24 (December 20, 2020): 38–41. http://dx.doi.org/10.33667/2078-5631-2020-24-38-41.

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Objective. To evaluate the effect of low doses of systemic isotretinoin in monotherapy and combination on the qualitative and quantitative composition of the microbiota in patients with acne with moderate papulo-pustular acne.Materials and methods. 78 patients were monitored on an outpatient basis. Group 1 consisted of 38 patients. This group was divided into two age subgroups: A (12–24 years; n = 18) and B (25–45 years; n = 20). All patients in group 1 received monotherapy in the form of systemic administration of isotretinoin at a dose of 0.5–0.7 mg per 1 kg of body weight per day daily for

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Patwardhan, Nitish, Aditya Kale, Biswa Ranjan Patra, et al. "Retained Biliary Plastic Stents: Clinical Presentation, Complications, and Management." Journal of Digestive Endoscopy 15, no. 01 (2024): 4–9. http://dx.doi.org/10.1055/s-0043-1778073.

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Abstract Background Biliary plastic stent (PS) mandates timely removal or replacement. The coronavirus disease 2019 (COVID-19) pandemic had affected the accessibility to medical therapy resulting in delay. We evaluated the burden of retained biliary PS, clinical profile, and impact of COVID-19 pandemic on stent retention. Material and Method Endoscopy database records between November 2019 and April 2022 were reviewed retrospectively to identify patients who had undergone stent exchange or removal > 3 months, that is, retained stents. Demography, comorbidity, indication and outcomes of inde

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