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Relevant bibliographies by topics / 3-amino-6-bromo-2-methyl quinazolin-4(3H)-one

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Academic literature on the topic '3-amino-6-bromo-2-methyl quinazolin-4(3H)-one'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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Journal articles on the topic "3-amino-6-bromo-2-methyl quinazolin-4(3H)-one"

1

Patel, J. A., B. D. Mistry, and K. R. Desai. "Synthesis and Antimicrobial Activity of Newer Quinazolinones." E-Journal of Chemistry 3, no. 2 (2006): 97–102. http://dx.doi.org/10.1155/2006/586512.

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2–alkyl–6–bromo–3,1–benzoxazine–4–one (2) is synthesized by treatingp–Bromoanthranilic acid and Acetylechoride or Benzoylchloride. Reaction of 2–alkyl–6–bromo–3,1–benzoxazine–4–one (2). with hydrazinehydrate furnish the corresponding 3–Amino–2–methyl–6–bromoquinazoline–4(3H)–one (3) which on reaction with benzaldehyde affordN,N– arylidene derivative (4). Reaction of 4 with various diazonium salts yields 6–bromo–2–alkyl/aryl–3{[phenyl(phenyldiazenyl)methylene]amino}quinazolin–4(3H)–one .

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2

Osarumwense, P. O. "Synthesis and Analgesic Activity of 3-Amino-6-Bromo-2-Methyl Quinazolin-4(3H) –One and 6-Bromo-2-Methyl-4H-Benzo[D] [1,3]- Oxazin-4-One." Continental J. Applied Sciences 12, no. 3 (2017): 29–39. https://doi.org/10.5281/zenodo.995719.

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<em>The current study is aimed at the synthesis and Analgesic evaluation of quinazolinone derivatives. The condensation of Methyl-2-amino-5-bromobenzoate with acetic anhydride yielded the cyclic compound 2-methyl 6-bromo-1, 3-benzo-oxazine-4-one which further produce 3-Amino-2-Methyl 6-bromoquinazolin4(3H)-ones via the reaction with hydrazine hydrate. The compounds synthesized were unequivocally confirmed by means of Chromatography Mass Spectrophotometer and Elemental analysis. The quinazolonones were evaluated pharmacologically for their in-vivo analgesic activities by acetic acid induced wri

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3

Mikra, Chrysoula, Maria Bairaktari, Marina-Theodora Petridi, Anastasia Detsi, and Konstantina C. Fylaktakidou. "Green Process for the Synthesis of 3-Amino-2-methyl-quinazolin-4(3H)-one Synthones and Amides Thereof:DNA Photo-Disruptive and Molecular Docking Studies." Processes 10, no. 2 (2022): 384. http://dx.doi.org/10.3390/pr10020384.

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Eleven 3-amino-2-methyl-quinazolin-4(3H)-ones have been synthesized, in good to excellent yields, via their corresponding benzoxazinones using an efficient tandem microwave-assisted green process. Representative acetamides have been thermally derived from their functional free 3-amino group, whereas for the synthesis of various arylamides, a novel green microwave-assisted protocol has been developed, which involved the attack of hydrazides on benzoxazinones. Eight out of the eleven 3-amino-2-methyl-quinazolin-4(3H)-ones were found photo-active towards plasmid DNA under UVB, and four under UVA

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4

Eweas, Ahmad Farouk, Qasem Mahmoud Aref Abdallah, and Mohamed Fouad Elbadawy. "Synthesis and biological evaluation of some new 2-pyridylquinazoline derivatives." Current Chemistry Letters 10, no. 4 (2021): 459–70. http://dx.doi.org/10.5267/j.ccl.2021.4.005.

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2-pyridyl [3H]-quinazolin-4-one derivatives fused or substituted with different oxygen or nitrogen heterocycle moieties as potential anti-tumor and anti-microbial agents were prepared, characterized and biologically screened. The synthesis process started from 5-bromo-2-[pyridin-4-ylcarbonyl]amino]benzoic acid which was converted to the crucial building block 6-Bromo-2-(pyridin-4-yl)quinazolin-4(3H)-one via two alternative routes. Compound 3 underwent halogenation reaction POCl3 and PCl5 to afford compound 6-Bromo-4-chloro-2-(pyridin-4-yl)quinazoline 4. The novel cyclized products 5a,b-10 were

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5

Dahikar, Girish D., and Rajendra O. Ganjiwale. "Synthesis, Spectral Characterization, in silico Molecular Docking and Pharmacological Screening of Some Quinazoline Analogues as Anticonvulsants." Asian Journal of Chemistry 37, no. 6 (2025): 1415–20. https://doi.org/10.14233/ajchem.2025.33816.

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A new analogues of 2-methyl-3-(6-substituted-benzothiazol-2-yl)-3H-quinazolin-4-one [Dm1-Dm5] and their 6-bromo analogues [Dm6-Dm10], similarly a new analogues of 2-methyl-3-(pyridin-4-yl-formamide)-3H-quinazolin-4-one [Em1] and its 6-bromo analogue [Em2] were synthesized and characterized by melting point, elemental and spectral [FTIR, (1H and 13C) NMR and MS] methods. The anticonvulsant activity of selected analogues was assessed against maximal electroshock (MES) induced convulsions model in albino mice. The selected analogues were injected intraperitoneally at dose 20 mg/kg body weight and

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6

Osarumwense, Osarodion Peter. "Synthesis and antibacterial activity of 3-amino-6-iodo-2-methyl quinazolin 4-(3H)-one and 6-iodo-2-methyl-4H-benzo [D] [1, 3] oxazin-4-one." World Journal of Advanced Research and Reviews 2, no. 3 (2019): 014–20. https://doi.org/10.5281/zenodo.4309464.

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Quinazolines and its derivatives represent one of the most active classes of compounds, which possess wide range of biological activities like anti-bacterial, analgesic, anti-microbial, anti-inflammatory, anticancer, and anti-hypertensive ,antifungal, anti-HIV, antioxidant, analgesic, anticonvulsant, antimalarial, antitumor, anti-tubercular activities. The objective of the present study was to synthesize these quinazolinone derivatives 6-iodo-2-methyl-4H-benzo[d]-[1,3]-oxazin-4-one and 3-amino-6-iodo-2—methyl-3H-quinazolin-4-one and evaluate them for their antibacterial activity. 6-lodo-

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7

Osarumwense Peter Osarodion. "Design, synthesis and antibacterial activity of novel metal complex of 3-amino-2-methyl 6-1odo quinazolin-4(3H)-one." International Journal of Frontiers in Biology and Pharmacy Research 3, no. 1 (2022): 001–8. http://dx.doi.org/10.53294/ijfbpr.2022.3.1.0044.

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Introduction: 4(3H)-quinazolinone rings have been reported to possess different biological activities such as antibacterial, antifungal, antitubercular, antiviral, anticancer. These activities also include antihypertensive, diuretic, antimicrobial, pesticidal, anticonvulsant, anaesthetic and sedative activities, anti-malarial, and anti-diabetic.The above observations and findings stimulated my interest to synthesize these novel, Co (ll) , Cu (ll) and Zn (ll) complexes of 3-amino-2-methyl-6-lodo-quinazolin-4 (3H)-one compounds. Methods: A new Ligand 3-amino-2-methyl 6-Iodo quinazolin-4(3H)-One

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8

Osarumwense, Peter Osarodion. "Synthesis and antibacterial activity of newly synthesized 7-chloro–2–methyl-4h–benzo[d] [1, 3]–oxazin–4–one and 3–amino-7-chloro-2–methyl-quinazolin-4(3h)–one." GSC Biological and Pharmaceutical Sciences 11, no. 1 (2020): 212–20. https://doi.org/10.5281/zenodo.4277223.

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The current study is aimed at the synthesis of these quinazolinone derivatives 7-Chloro-2-Methyl-4H-benzo[d]-[1,3]-Oxazin-4-one and 3-Amino-7-Chloro-2—Methyl-3H-Quinazolin-4-One and evaluate them for their antibacterial activity.The condensation of 2-amino-methyl-4-methoxybenzoate with acetic anhydride yielded the cyclic compound 2-methyl-4, 5-disubstituted-1, 3-benzo-oxazine-4-one which further produce a novel 2,3-disubstituted quinazolin-4 ones via the reaction with hydrazine hydrate The quinazolinone derivatives 7-chloro-2-methyl-4H-benzo[d][1,3]-oxazin-4-one and 3-amino-7-chloro-2-me

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9

Thuy, Linh Bui Thi, Phuoc Le Thien, Hien Dang Chi, Hai Ha Pham Thi, and Cong Nguyen Tien. "Synthesis and antibacterial activities of some novel hybrid compounds based on 2‐mercapto‐3‐arylquinazolin‐4(3H)‐one scaffold bearing specific coumarin." Vietnam Journal of Chemistry 61, S2 (2023): 131–36. http://dx.doi.org/10.1002/vjch.202300093.

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AbstractTwo series of novel hybrid compounds, in which a variety of 2‐mercapto‐3‐arylquinazolin‐4(3H)‐ones (3a‐d)/6‐bromo‐2‐mercapto‐3‐phenylquinazolin‐4(3H)‐one (9) act as fundamental moieties are incorporated in particular 3‐(2‐bromoacetyl)‐2H‐chromen‐2‐one (4) or 2‐chloro‐N‐(2‐oxo‐2H‐chromen‐3‐yl)acetamide (5) via alkylation of the thiol group in quinazolin‐4(3H)‐one ring, were synthesized. The key intermediates (3a‐d) and (9) were prepared by the reaction of anthranilic acid (1)/2‐amino‐5‐bromobenzoic acid (8) with carbon disulfide and appropriate aromatic amines in an alkaline medium. The

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10

Peter Osarodion, Osarumwense, and Omotade Treasure Ejodamen. "Electron Impact Ionization Mass Spectra of 3-Amino 6-Chloro-2-methyl Quinazolin-4-(3H)-one Derivative." American Journal of Materials Synthesis and Processing 6, no. 1 (2021): 20. http://dx.doi.org/10.11648/j.ajmsp.20210601.13.

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