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Dissertations / Theses on the topic '3-dioxygenase'

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Published: 4 June 2021

Last updated: 7 July 2024

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1

Alameer, Fouad Elrafaie Ali. "Synthesis of mechanism probes and potential inhibitors for tryptophan 2, 3-dioxygenase and indoleamine 2, 3-dioxygenase enzymes." Thesis, University of Leicester, 2017. http://hdl.handle.net/2381/39876.

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In biological terms, the kynurenine pathway is considered as a one of the major degradation pathway of tryptophan (L-Trp) in which the first and rate-limiting step in this pathway is the oxidation of L-Trp to N-formylkynurenin (NFK). In spite of the fact that many mechanism have been proposed to explain how the transformation occurs, the mechanism of this oxygen-dependent reaction has not yet been determined. Nonetheless, this type of unique reaction is catalysed by two heme-containing dioxygenase enzymes:- tryptophan 2,3-dioxygenase (TDO), and indoleamine 2,3-dioxygenase (IDO), and due to the

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2

Habibi, Darya. "Mechanisms of selective immunosuppressive effects of indoleamine 2, 3-dioxygenase and borrelidin." Thesis, University of British Columbia, 2011. http://hdl.handle.net/2429/36674.

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Indoleamine 2, 3-dioxygenase (IDO), a tryptophan degrading enzyme, is a potent immunomodulatory factor that has been considered as a promising candidate in down-regulating alloimmune responses. IDO expression generates a tryptophan-deficient environment that selectively induces apoptosis in immune cells but not in primary skin cells. However, the mechanism(s) underlying these selective effects of IDO is not elucidated. In this doctoral research project, we hypothesize that different sensitivity of immune cells versus skin cells to IDO-induced tryptophan-deficient environment is due to the diff

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3

Fu, Rong. "Biochemical and Spectroscopic Characterization of Tryptophan Oxygenation: Tryptophan 2, 3-Dioxygenase and Maug." Digital Archive @ GSU, 2009. http://digitalarchive.gsu.edu/chemistry_diss/44.

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TDO utilizes b-type heme as a cofactor to activate dioxygen and insert two oxygen atoms into free L-tryptophan. We revealed two unidentified enzymatic activities of ferric TDO from Ralstonia metallidurans, which are peroxide driven oxygenation and catalase-like activity. The stoichiometric titration suggests that two moles of H2O2 were required for the production of one mole of N-formylkynurenine. We have also observed monooxygenated-L-tryptophan. Three enzyme-based intermediates were sequentially detected in the peroxide oxidation of ferric TDO in the absence of L-Trp including compound I-typ

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4

Galik, Ryan. "Inhibition of Cytokine Induced Indoleamine 2, 3-Dioxygenase Expression in a Human Monocytic Cancer Cell Line." Ohio University / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1535036948694968.

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5

Arefayene, Million. "Identification and functional characterization of genetic variants in the human indoleamine 2, 3-dioxygenase (INDO) gene." Thesis, Connect to resource online, 2008. http://hdl.handle.net/1805/1704.

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Thesis (Ph.D.)--Indiana University, 2008.<br>Title from screen (viewed on June 4, 2009). Department of Pharmacology and Toxicology, Indiana University-Purdue University Indianapolis (IUPUI). Advisor(s): David A. Flockhart. Includes vita. Includes bibliographical references (leaves 124-139).

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6

Karvelis, Laimonas. "Investigation of the Degradation of Carboxypyridines in Bacteria." Doctoral thesis, Lithuanian Academic Libraries Network (LABT), 2012. http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2012~D_20121001_092919-52075.

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The main aim of this work was the study of bacteria capable to degrade the pyridine monocarboxylic acids. Achromobacter sp. strain JS18 capable to utilize 3-hydroxypyridine- 2-carboxylic acid was selected by screening of microorganisms hydroxylating the pyridine ring at unusual positions or transforming pyridine derivatives . The strain 5HP consuming 5- hydroxypyridine-2-carboxylic acid as a sole carbon and energy source was isolated from soil. The 16S rRNA-based phylogenetic analysis showed that the isolate belongs to Pusillimonas genus. It was found that picolinic, nicotinic and dipicolinic

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7

Pelletier, Matthew K. "Molecular and Biochemical Genetics of 2-Oxoglutarate-Dependent Dioxygenases Required for Flavonoid Biosynthesis in Arabidopsis thaliana." Diss., Virginia Tech, 1997. http://hdl.handle.net/10919/30599.

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Three 2-oxoglutarate-dependent dioxygenases required for flavonoid biosynthesis were characterized in Arabidopsis thaliana. Genes encoding flavanone 3-hydroxylase (F3H), flavonol synthase (FLS), and leucoanthocyanidin dioxygenase (LDOX) were cloned and sequenced. The predicted proteins encoded by each of these Arabidopsis genes shared high homology with all F3H, FLS, or LDOX sequences available in Genbank. Low-stringency DNA blot analysis indicated that F3H and LDOX are encoded by a single gene in Arabidopsis, while FLS may be encoded by two or three genes. RNA blot analysis was performed

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8

Baradar, Jalili Reza. "Development and application of a non-rejectable composite pancreatic islet allograft using indoleamine 2, 3 dioxygenase in a diabetic mouse model." Thesis, University of British Columbia, 2009. http://hdl.handle.net/2429/24154.

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Success of transplantation of pancreatic islets as a promising therapeutic method for restoring efficient regulated insulin secretion in type 1 diabetes depends on lifelong use of immunosuppressive drugs. With the goal of eliminating the necessity of systemic immunosuppressive agents after islet transplantation, in this doctoral research project we hypothesized that a novel non-rejectable islet graft through employing a local immunosuppressive factor, indoleamine 2, 3 dioxygenase (IDO) can be developed and applied. IDO is a tryptophan degrading enzyme and functions as a potent immunomodulatory

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9

Schmid, Manuela. "Eimeria falciformis infection of mouse cells identifies host determinants of parasite development." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2014. http://dx.doi.org/10.18452/17001.

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Eimeria falciformis ist ein Apicomplexa-Parasit, welcher das Blinddarmepithel der Maus befällt. Aufgrund des monoxenen Lebenszyklus in einem exzellent-erforschten Wirt, bietet sich E. falciformis als Modellorganismus an, um Wirts-Parasit-Interaktionen zu untersuchen. Im Rahmen dieser Arbeit wurden mit Hilfe von Genexpressionsanalysen bei E. falciformis-infizierten Zellen und Mäusen Wirtsfaktoren identifiziert, welche für die in vitro bzw. in vivo Entwicklung des Parasiten vonnöten sind. Der Transkriptionsfaktor c-FOS (FBJ osteosarcoma oncogene) zeigte eine erhöhte Expression bei der Infektion

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10

Francis, Kevin. "On the Biochemistry, Mechanism and Physiological Role of Fungal Nitronate Monooxygenase." Digital Archive @ GSU, 2011. http://digitalarchive.gsu.edu/chemistry_diss/51.

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Nitronate monooxygenase (E.C. 1.13.11.16), formerly known as 2-nitropropane dioxygenase (EC 1.13.11.32), is a flavin dependent enzyme that catalyzes the oxidation of nitronates to their corresponding carbonyl compounds and nitrite. Despite the fact that the enzyme was first isolated from Neurospora crassa 60 years ago, the biochemical and physiological properties of nitronate monooxygenase have remained largely elusive. This dissertation will present the work that established both the catalytic mechanism and physiological role of the fungal enzyme. The biological and biochemical properties of

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11

Watcharanurak, Kanitta. "Gene therapy of atopic dermatitis and cancer by sustained expression of interferon-γ in mice". 京都大学 (Kyoto University), 2013. http://hdl.handle.net/2433/180542.

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12

Araujo, Eliseu Frank de. "A IDO controla a carga fúngica e a imunidade celular de camundongos suscetíveis e resistentes à infecção pelo Paracoccidioides brasiliensis." Universidade de São Paulo, 2009. http://www.teses.usp.br/teses/disponiveis/42/42133/tde-02022010-124420/.

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Indolamina-2,3-dioxigenase (IDO) e o catabolismo do triptofano estão envolvidos no controle da imunidade inata e adaptativa contra patógenos. Investigamos o papel da IDO na paracoccidiodomicose pulmonar (PCM) de animais suscetíveis (B10.A) e resistentes (A/J) ao fungo. Observou-se uma ação marcante da IDO ao início da doença de camundongos B10.A onde a enzima controla a carga fúngica mas, também, induz anergia de células TCD4+ e TCD8+, creditada em parte à expansão de células Treg e aumento de linfócitos em apoptose. Em camundongos A/J, a IDO controla a carga fúngica inicial, porém, o seu efei

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13

Salvadori, Maria Leticia Baptista. "Expressão da indoleamina-2,3-dioxigenase em células cancerígenas de pacientes com câncer de mama." Universidade de São Paulo, 2015. http://www.teses.usp.br/teses/disponiveis/10/10132/tde-09122015-140802/.

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O câncer de mama é o tipo de câncer mais comum entre as mulheres e a sobrevivência de pacientes por ele acometidos está aumentando graças a diversas novas abordagens relacionadas ao seu diagnóstico precoce e a tratamentos mais eficientes. A enzima indoleamina- 2,3 dioxigenase (IDO) é expressa por diversas células e também por células tumorais. Esta enzima atua inibindo a proliferação de linfócitos T, comprometendo a atividade citotóxica do mesmo. O 1-metil-DL-triptofano (1MT) é um inibidor competitivo da IDO, que bloqueia seu efeito imunossupressor e poderia cooperar com a quimioterapia na re

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14

Borel, Michèle. "Dégradation de composés benzoi͏̈ques par un pseudomonas du sol." Grenoble 1, 1987. http://www.theses.fr/1987GRE10086.

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La bacterie appelee gu5, isolee du sol, identifiee comme un pseudomonas, utilise les acides vanillique, isovanillique ou 4-hydroxybenzoique comme seule source de carbone et d'energie. L'acide protocatechuique a ete identifie comme intermediaire commun du catabolisme de ces substrats. La demethylation des acides vanillique et isovanillique est realisee par deux systemes enzymatiques distincts. Ces reactions de demethylation n'ont pu etre observees dans les lysats bacteriens. La 4-hydroxybenzoate 3-hydroxylase, nadph dependante a ete purifiee et etudiee. C'est une enzyma flavinique contenant du

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15

Maza, William Antonio. "Reaction Enthalpy and Volume Profiles for Excited State Reactions Involving Electron Transfer and Proton-Coupled Electron Transfer." Scholar Commons, 2013. http://scholarcommons.usf.edu/etd/4539.

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Electron transfer, ET, and proton-coupled electron transfer, PCET, reactions are central to biological reactions involving catalysis, energy conversion and energy storage. The movement of electrons and protons in either a sequential or concerted manner are coupled in a series of elementary reaction steps in respiration and photosynthesis to harvest and convert energy consumed in foodstuffs or by absorption of light into high energy chemi-cal bonds in the form of ATP. These electron transfer processes may be modulated by conformational dynamics within the protein matrix or at the protein-protei

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16

Vallius, Laura I. "Modulating the immune system by amino acid depletion : IDO and beyond." Thesis, University of Oxford, 2011. http://ora.ox.ac.uk/objects/uuid:eb1a1987-4121-4042-be82-2aafb67c9941.

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Amino acid availability plays an important role in modulating the activity of T-cells. One of the pathways employed by T-cells to sense nutrient levels is the “mammalian target of rapamycin” (mTOR) pathway that is inhibited in response to nutrient depletion. Indoleamine 2,3-dioxygenase (IDO) is the first and rate-limiting enzyme along the tryptophan catabolising kynurenine pathway. T-cells are very sensitive to lack of this essential amino acid in their microenvironment and this confers strong immunomodulatory properties to cells expressing active IDO. It therefore has a significant physiologi

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17

Day, Andrea Anneliese Reichmuth. "Nível de expressão tumoral da indoleamine 2,3-dioxigenase (IDO) como marcador biológico e preditor de metástase em pacientes com tumor carcinoide típico broncopulmonar." Universidade de São Paulo, 2011. http://www.teses.usp.br/teses/disponiveis/5/5156/tde-24022012-162815/.

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Os tumores carcinoides típicos broncopulmonares (TCTB) são considerados neoplasias bem diferenciadas e as menos agressivas dentro do espectro dos tumores neuroendócrinos. Entretanto, metástases linfonodais e hematogênicas tem sido encontradas em número considerável de casos e não existem, até o momento, estudos relacionados aos mecanismos de escape imune tumoral em TCTB. Alguns trabalhos tem relacionado a expressão da enzima indoleamine 2,3-dioxigenase (IDO) em células neoplásicas como fator responsável pela aquisição de tolerância tumoral. Além disso, os níveis de infiltração linfocitária int

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Denoeud, Julie N. O. "Etude des mécanismes cellulaires et moléculaires impliqués dans la fonction suppressive des lymphocytes T régulateurs." Doctoral thesis, Universite Libre de Bruxelles, 2010. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/210087.

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La réponse immune représente une réponse complexe à laquelle correspond une succession d’événements orchestrés finement. Parmi les mécanismes qui régulent la réponse immune, les lymphocytes T régulateurs (Tregs) assurent le maintien de la tolérance en périphérie et le contrôle des réponses immunes adaptatives. Ils représentent une population hétérogène et leurs mécanismes de suppression sont toujours l’objet d’intenses recherches. Suivant le contexte de suppression et leur nature, les lymphocytes Tregs réalisent une inhibition de l’activation des lymphocytes Th, soit directement, soit via la m

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COSTA, Eula Maria de Melo Barcelos. "Metabolização da quercetina e produção de quercetina 2,3-dioxigenase por Beauverias bassianas isoladas da região Centro-Oeste do Brasil." Universidade Federal de Goiás, 2009. http://repositorio.bc.ufg.br/tede/handle/tde/1554.

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Made available in DSpace on 2014-07-29T15:25:23Z (GMT). No. of bitstreams: 1 Tese_Eula_Costa.pdf: 1234220 bytes, checksum: 9b0a765b29a3c24c4ab992c52d3cab65 (MD5) Previous issue date: 2009-03-25<br>Considering the vast biotechnological applicability described for Beauveria bassiana, the versatility microbial biotransformation exhibits, the important biological activities attributed to the flavonoid quercetin, the therapeutic perspectives of its use, and the activity the enzyme quercetin 2,3-dioxygenase has on quercetin, we intended to evaluate quercetin biotransformation by B. bassiana ATCC 7

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20

Parks, Samantha Terris. "Genes encoding the key enzymes for the bacterial degradation of the natural nitro compounds 3-nitrotyrosine and 1-nitro-2-phenylethane." Diss., Georgia Institute of Technology, 2010. http://hdl.handle.net/1853/34002.

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Natural nitro compounds with diverse structures and biological functions are produced by bacteria, fungi, plants and animals. Little is known about the behavior of such compounds in natural ecosystems. The lack of accumulation in the biosphere implies that they are biodegraded. Microbial strategies for biodegradation of synthetic nitro compounds are well established; however only two pathways are known for degradation of natural nitro compounds. The research described here examines the genes that encode the key enzymes required for biodegradation of 3-nitrotyrosine (3NTyr) and 1-nitro-2-ph

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Ruotsalainen, H. (Heli). "Lysyl hydroxylases:characterization of mouse lysyl hydroxylases and generation of genetically modified lysyl hydroxylase 3 mouse lines." Doctoral thesis, University of Oulu, 2005. http://urn.fi/urn:isbn:9514277392.

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Abstract Lysyl hydroxylase (EC 1.14.11.4, procollagen-lysine, 2-oxyglutarate, 5-dioxygenase, Plod) catalyzes the hydroxylation of certain lysine residues in collagens and in other proteins with collagenous domains. Three lysyl hydroxylase isoforms have been cloned from human and rat. The importance of lysyl hydroxylase 1 in collagen biosynthesis is demonstrated by the heritable disorder, Ehlers-Danlos syndrome type VI, which is characterized by joint laxity, progressive scoliosis, muscle hypotonia, scleral fragility and rupture of the ocular globe. An alternatively spliced form of lysyl hydrox

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Takaluoma, K. (Kati). "Lysyl hydroxylases:studies on recombinant lysyl hydroxylases and mouse lines lacking lysyl hydroxylase 1 or lysyl hydroxylase 3." Doctoral thesis, University of Oulu, 2007. http://urn.fi/urn:isbn:9789514284281.

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Abstract Lysyl hydroxylases (E.C. 1.14.11.4, LHs) have three isoenzymes that are found in humans and mice, and they hydroxylate lysine residues in collagens and other proteins containing collagenous sequences. The hydroxylysines formed are crucial for the intermolecular collagen crosslinks that stabilise collagen fibres, thereby providing the stiffness and stability required by various tissues. In addition, hydroxylysines serve as attachment sites for carbohydrates, whose functions on collagen molecules are not completely understood yet. In humans, lack of LH1 causes Ehlers-Danlos syndrome (ED

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23

Owens, Daniel Kenneth. "Examination of 2-Oxoglutarate Dependant Dioxygenases Leading to the Production of Flavonols in Arabidopsis thaliana." Diss., Virginia Tech, 2005. http://hdl.handle.net/10919/29144.

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The flavonols are a varied and abundant sub-class of flavonoids that are associated with a number of essential physiological functions in plants and pharmacological activities in animals. The 2-oxoglutarate-dependant dioxygenases(2-ODDs), flavonol synthase (FLS) and flavanone 3-hydroxylase (F3H), are essential for flavonol synthesis. The primary goal of this study has been to gain a deeper understanding of the biochemistry of these enzymes in Arabidopsis. To accomplish this goal, an activity assay employing recombinant protein expression and HPLC as a detection system was developed for F3H an

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24

Salmon, Thierry. "Presença da proteína Indoleamina 2, 3-dioxigenase (IDO) na interface materno-fetal de Prionace glauca (Linnaeus, 1758)." Universidade de São Paulo, 2015. http://www.teses.usp.br/teses/disponiveis/10/10132/tde-25112015-142332/.

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O tubarão-azul (Prionace glauca) é uma espécie que apresenta desenvolvimento vivíparo placentário em que o saco vitelino se desenvolve ao longo da gestação tornando-se uma placenta que executa função matrotrófica. A Indoleamina 2,3-dioxigenase (IDO) é uma proteína encontrada em mamíferos nos quais participa, além de outras funções, da tolerância materno-fetal, sendo também encontrada em peixes ósseos. Assim, a proposta deste trabalho foi verificar a expressão da IDO na interface materno-fetal de Prionace glauca e descrever sua localização. Para tanto, material placentário/uterino e embriológ

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Salo, A. (Antti). "Expression of lysyl hydroxylases and characterization of a novel disorder caused by mutations in the lysyl hydroxylase 3 gene." Doctoral thesis, University of Oulu, 2009. http://urn.fi/urn:isbn:9789514291739.

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Abstract Collagens and collagenous proteins undergo several post-translational modifications that are important for their structure and functions. Lysine hydroxylation produces hydroxylysines, which are important for collagen cross-link formation and provide attachment sites for galactose and glucosylgalactose. Glycosylated hydroxylysines are crucial for embryonic development and the assembly of certain collagen types. They may also facilitate interactions between collagen and adjacent molecules as well as control the diameter of collagen fibrils. Lysine hydroxylation is catalyzed by three lys

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Webb, James D. "Studies on HIF hydroxylases." Thesis, University of Oxford, 2008. http://ora.ox.ac.uk/objects/uuid:5dd74f32-9579-484e-885f-3f57a1e9f24f.

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Hypoxia-inducible factor (HIF) is the master regulator of genes involved in adaptation to hypoxia. The stability and transcriptional activity of HIF are regulated by post-translational hydroxylations: prolyl hydroxylation by the prolyl hydroxylase domain-containing enzymes PHD1 – 3 earmarks HIF for proteasomal degradation, whilst asparaginyl hydroxylation by factor inhibiting HIF (FIH) blocks the interaction of HIF with the transcriptional coactivators p300/CBP. The PHDs and FIH hydroxylate HIF directly from molecular oxygen and are therefore oxygen sensors. Recent literature shows that FIH al

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Frerichs-Deeken, Ursula [Verfasser]. "Bakterielle 2,4-Dioxygenasen : Untersuchungen zur Aufklärung des Katalysemechanismus der cofaktorfreien 1H-3-Hydroxy-4-oxochinaldin-2,4-Dioxygenase / von Ursula Frerichs-Deeken." 2008. http://d-nb.info/989265854/34.

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Chang, Yu-Shun, and 張宇舜. "Studies For The Inhibition Of Catechol 2,3-Dioxygenase By 3–Substituted Catechols." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/06518074797177528915.

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碩士<br>國立中正大學<br>化學暨生物化學研究所<br>100<br>The environmental impact of industrial pollution leads to more and more troubles in human lives. Among them, aromatic compounds are accounted for a large part of these pollutants. Structurally, these aromatic compounds are very stable and very difficult to be degraded. These compounds cause health risks. Aerobic microbial decomposition of aromatic compounds in nature degrades such compounds to less toxic or non-toxic products at room temperature and under atmospheric pressure. Usually, these organisms degrade those aromatic compounds into catechol intermedi

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Kuan, Yu-Diao, and 管玉貂. "Salmonella break tumor immune tolerance by downregulation tumor indoleamine 2, 3-dioxygenase 1 expression." Thesis, 2015. http://ndltd.ncl.edu.tw/handle/4rgs5u.

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Cravetchi, Olga Vladimir. "The role of eosinophils in the neonatal murine thymus expression of indoleamine 2, 3-dioxygenase /." 2009. http://hdl.handle.net/10048/543.

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Thesis (M.Sc.)--University of Alberta, 2009.<br>A thesis submitted to the Faculty of Graduate Studies and Research in partial fulfillment of the requirements for the degree of Master of Science in Experimental Medicine, Department of Medicine. Title from pdf file main screen (viewed on September 16, 2009). Includes bibliographical references.

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Borra, Jalandhar B. "Synthesis and biological evaluation of indoleamine 2, 3-dioxygenase inhibitors and induction, inhibition studies of Tryptophanase." 2005. http://purl.galileo.usg.edu/uga%5Fetd/borra%5Fjalandhar%5Fb%5F200508%5Fms.

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Thesis (M.S.)--University of Georgia, 2005.<br>Directed by Robert S. Phillips. For abstract see http://getd.galib.uga.edu/public/borra_jalandhar_b_200508_ms/borra_jalandhar_b_200508_ms.pdf. Includes bibliographical references.

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Rajamani, Karthyayani, and Karthyayani Rajamani. "n-Butylidenephthalide exhibits protection against neurotoxicity through regulation of tryprophan 2,3 dioxygenase in spinocerebellar ataxia type 3." Thesis, 2016. http://ndltd.ncl.edu.tw/handle/tfda5y.

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博士<br>國立東華大學<br>生命科學系<br>105<br>Spinocerebellar ataxia type 3 or Machado-Joseph disease (SCA3/MJD) is characterized by the repetition of a CAG codon in the ataxin-3 gene (ATXN3), which leads to the formation of an elongated mutant ATXN3 protein that can neither be denatured nor undergo proteolysis in the normal manner. This abnormal proteolysis leads to the accumulation of cleaved fragments, which have been identified as toxic and further they act as a seed for more aggregate formation, thereby increasing toxicity in neuronal cells. To date, there have been few studies or treatment strategies

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Chen, Hung-Chi, and 陳鴻吉. "Abscisic Acid-Mediated Heterophylly Is Regulated by Differential Expression of 9-cis-Epoxycarotenoid Dioxygenase 3 in Lilies." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/87684061681703883357.

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博士<br>國立臺灣大學<br>園藝學研究所<br>100<br>Although exogenous ABA-regulated heterophylly has been well documented in multiple plant species, the effect of endogenous ABA and its molecular mechanism remain uncharacterized. In the present study, the effects of endogenous ABA on heterophyllous switching were investigated in two different lily varieties, Lilium formosanum and Lilium oriental hybrid ‘Casa Blanca’. Seedlings of L. formosanum, which have scale-leaf-type growth, displayed low levels of both 9-cis-epoxycarotenoid dioxygenase 3 (LfNCED3) transcripts and ABA, whereas seedlings of L. oriental hybri

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Jalili, R. B., R. T. Kilani, Y. Li, et al. "Fibroblast cell-based therapy prevents induction of alopecia areata in an experimental model." 2018. http://hdl.handle.net/10454/16554.

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Yes<br>Alopecia areata (AA) is an autoimmune hair loss disease with infiltration of proinflammatory cells into hair follicles. Current therapeutic regimens are unsatisfactory mainly because of the potential for side effects and/or limited efficacy. Here we report that cultured, transduced fibroblasts, which express the immunomodulatory molecule indoleamine 2,3-dioxygenase (IDO), can be applied to prevent hair loss in an experimental AA model. A single intraperitoneal (IP) injection of IDO-expressing primary dermal fibroblasts was given to C3H/HeJ mice at the time of AA induction. While 60–70%

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Russell, Teresa Lynn. "Pathologic effects of uremia in the kidney and brain." Thesis, 2020. https://hdl.handle.net/2144/41174.

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Chronic kidney disease (CKD), a reduction in kidney function, has reached pandemic proportions and imposes a major healthcare burden worldwide. A hallmark of CKD is the accumulation of several chemical compounds, called uremic toxins, which inflict systemic and renal-specific damage. Of the known uremic toxins, kynurenine (Kyn) is known to be particularly vasculotoxic and is implicated in several complications of CKD. Indoleamine 2,3-dioxygenase 1 (IDO), which catalyzes the first step in the metabolism of Tryptophan (Trp), regulates immune response to inflammatory cytokines in tissues. IDO pla

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Gan, Yu-Ling, and 甘育菱. "Roles of Aryl Hydrocarbon Receptor in the Indoleamine 2, 3-Dioxygenase/Kynurenine Pathway and the Expression of Proinflammatory Cytokines and Aquaporin-4 in the Lipopolysaccharide-Induced Astrogliosis." Thesis, 2013. http://ndltd.ncl.edu.tw/handle/04976760872874933030.

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碩士<br>國立陽明大學<br>生理學研究所<br>101<br>Inflammatory insult-induced astrocyte reactivation plays important roles in the neuronal survival and injury repair after brain injuries. Previous studies have shown that kynurenine (Kyn) and kynurenic acid (KyA) are increased in the blood of post-stroke patients, which point to the possible activation of their synthesizing enzyme indoleamine 2, 3-dioxygenase (IDO). IDO catalyzes the biosynthesis of Kyn from L-tryptophan to modulate peripheral immune responses. IDO is inducible upon proinflammatory insults such as bacterial endotoxin lipopolysaccharide (LPS), a

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Lin, Huang Jian, and 黃建霖. "Design, Synthesis,and Evaluation as Inhibitors of 4-Hydroxyphenylpyruvate Dioxygenase and Synthesis and Evaluation of 3-Hydroxy-2-(2-nitrobenzoyl)2-cyclohexenone as a Selective Protecting Group for Primary Amines." Thesis, 2002. http://ndltd.ncl.edu.tw/handle/59076390669826684076.

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Tuan, Nguyen Ngoc, and 阮玉俊. "Study of the genes involved in the degradation of 4-t-octylphenol in Pseudomonas sp. TX1 and Acinetobacter sp. OP5 and the properties of alkylcatechol 2, 3-dioxygenase from strain OP5." Thesis, 2013. http://ndltd.ncl.edu.tw/handle/36406541928432606730.

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博士<br>國立中央大學<br>系統生物與生物資訊研究所<br>101<br>Long-chain alkylphenols (C=8-12), such as nonylphenols and octylphenols, are estrogen-like compounds that are persistent in the environment until they are degraded by bacteria. These compounds influence the growth, reproduction and sexual development of humans and other animals, therefore are a cause of health and ecology related concerns. Some studies of the biodegradation of long-chain alkylphenols have been reported. The mechanism of few Sphingomonas strains was reported using the ipso-hydroxylation mechanism by the analysis of degradation metabolites

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Di, Trapani Mariano. "Comparative study of immune regulatory properties of stem cells derived from different tissues." Doctoral thesis, 2015. http://hdl.handle.net/11562/910783.

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La terapia mediante l’uso di cellule staminali allogeniche è una potenziale alternativa per la cura di malattie infiammatorie e degenerative. Vari gruppi di ricerca hanno messo in luce le proprietà immunomodulatorie di varie cellule staminali, come per esempio le cellule mesenchimali stromali, ma al momento non è stato ancora fatto uno studio comparativo mostrante differenze qualitative e quantitative delle proprietà immunoregolatorie di staminali di diversa origine. Lo scopo del lavoro è stato quindi quello di confrontare le proprietà immunologiche di varie cellule staminali, tra cui cellule

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