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Journal articles on the topic '3-dipolar cycloadditions'

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1

Zhan, Desheng, Gang Yang, Tieli Zhou, Sashirekha Nallapati, and Xiaofeng Zhang. "Decarboxylation-Driven Double Annulations: Innovative Multi-Component Reaction Pathways." Molecules 30, no. 7 (2025): 1594. https://doi.org/10.3390/molecules30071594.

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A concerted five-component reaction strategy has been developed, featuring double [3+2] cycloadditions utilizing aspartic acid. This approach provides valuable insights into mechanistic pathways, allowing for the distinction between concerted and stepwise processes based on reaction efficiency and diastereoselectivity. Both aspartic and glutamic acids have been employed for a thorough evaluation and exploration of decarboxylation-driven double annulations. This method effectively constructs pyrrolizidine frameworks through a concerted double 1,3-dipolar cycloaddition with aspartic acid, as wel
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2

Nivedita, Acharjee, Banerji Avijit, and Gayen Biswajit. "Cycloaddition approach to five-membered heterocycles - Some recent experimental and theoretical aspects." Journal of Indian Chemical Society Vol. 88, Dec 2011 (2011): 1857–77. https://doi.org/10.5281/zenodo.5791817.

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Department of Chemtstry, Jalpaiguri Government Engineering College, Jalpatgun-735 102, West Bengal, India centre of Advanced Studies on Natural Products mcludmg Organic Synthesis, Department of Chemistry, University of Calcutta, 92, Acharya Prafulla Chandra Road, Kolkata-700 009, India <em>E-mail</em> :&nbsp;ablabcu@yahoo.co uk <em>Manuscript received 17 October 2011, accepted 20 October 2011</em> 1,3-Dipolar cycloaddition reactions of nitrones to substituted olefins give rise to synthetically useful isoxazolidines with up to three new chiral centers. The preferred regio- and stereochemical mo
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3

Zhong, Jiaxin, Haibing He, and Shuanhu Gao. "Exploration of 1,3-dipolar cycloaddition reactions to construct the core skeleton of Calyciphylline A-type alkaloids." Organic Chemistry Frontiers 6, no. 22 (2019): 3781–85. http://dx.doi.org/10.1039/c9qo01111k.

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4

Majer, Roberta, Olga Konechnaya, Ignacio Delso, et al. "Highly diastereoselective 1,3-dipolar cycloadditions of chiral non-racemic nitrones to 1,2-diaza-1,3-dienes: an experimental and computational investigation." Org. Biomol. Chem. 12, no. 44 (2014): 8888–901. http://dx.doi.org/10.1039/c4ob01371a.

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5

Jedlovská, Eva, Lubor Fišera, Anna Balková, Jaroslav Kováč, and Ladislav Štibrányi. "Cycloadditions of 2,5-dimethyl-3-furannitrile oxide to alkenes and alkynes." Collection of Czechoslovak Chemical Communications 55, no. 10 (1990): 2481–92. http://dx.doi.org/10.1135/cccc19902481.

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Regioselectivity of 1,3-dipolar cycloadditions of 2,5-dimethyl-3-furannitrile oxide (IIa) to alkenes or alkynes is described. Nitrile oxide IIa generated in situ reacts with monosubstituted alkenes or alkynes to give exclusively 5-substituted 3-(5-dimethyl-3 -furyl)-2-isoxazolines IV and isoxazoles V, 2,5-disubstituted alkenes sometimes afforded a mixture of regioisomeric isoxazolines. Reactivity of furannitrile oxides II and III in cycloadditions to ethene was studied by the MNDO method.
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6

Baldwin, Jack E., and Janos Pitlik. "1,3-Dipolar cycloadditions of 3-methylenecephams with diazoalkanes." Tetrahedron Letters 31, no. 17 (1990): 2483–86. http://dx.doi.org/10.1016/s0040-4039(00)97395-7.

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7

Vedejs, E., and R. G. Wilde. "2 + 3 Dipolar cycloadditions of a monomeric thioaldehyde." Journal of Organic Chemistry 51, no. 1 (1986): 117–19. http://dx.doi.org/10.1021/jo00351a032.

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8

Gucma, Mirosław, Marek Gołębiewski, Krzysztof Żelechowski, and Maria Krawczyk. "Studies on the [2+3] cycloaddition reaction of nitrile oxides to abietic acid esters." Journal of the Serbian Chemical Society 84, no. 10 (2019): 1073–81. http://dx.doi.org/10.2298/jsc180517018g.

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[2+3] Dipolar cycloadditions of aromatic nitrile oxides to abietic acid esters were investigated. The reactions showed complete site selectivity and regioselectivity, while the stereoselectivity depended on the structures of the dipolarophiles.
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9

Vale, Luís S. H. P., Joana F. B. Barata, Carla I. M. Santos, et al. "Corroles in 1,3-dipolar cycloaddition reactions." Journal of Porphyrins and Phthalocyanines 13, no. 03 (2009): 358–68. http://dx.doi.org/10.1142/s1088424609000371.

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The azomethine ylide generated from the reaction of a corrole-3-carbaldehyde and N-methylglycine was trapped with dimethyl fumarate, dimethyl acetylenedicarboxylate and fullerene C60 in 1,3-dipolar cycloadditions. A similar azomethine ylide generated from a corrole-2-carbaldehyde was trapped with 1,4-naphthoquinone, yielding the expected dehydrogenated 1,3-dipolar cycloadduct and a quinone-fused corrole derivative. A detailed synchrotron single-crystal X-ray diffraction analysis of the gallium(III)(pyridine) complex of 5,10,15-tris(pentafluorophenyl)corrole-3-carbaldehyde is also presented.
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10

Jäger, Volker, Wolfgang Frey, Yaser Bathich, et al. "2-Isoxazolinium Salts and 3-Isoxazolines: Exploratory Chemistry and Uses for the Synthesis of Branched Amino Polyols and Amino Acids." Zeitschrift für Naturforschung B 65, no. 7 (2010): 821–32. http://dx.doi.org/10.1515/znb-2010-0708.

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2-Isoxazolines represent a well known class of heterocycles, readily accessible in particular by 1,3-dipolar cycloaddition of nitrile oxides to alkenes. 2-Isoxazolines are easily transformed into 2- isoxazolinium salts by N-methylation, and further into 3-isoxazolines by deprotonation. In contrast to the parent system, less is known concerning the chemistry of the derived classes, and potential applications in synthesis. - 2-Isoxazolinium salts, due to their iminium part, are prone to the attack of nucleophiles, and examples for this, addition of hydride (reduction) and C-nucleophiles like met
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11

Ma, Ling-Ling, Wan Wang, and Gui-Chang Wang. "Theoretical investigations toward the [3 + 2]-dipolar cycloadditions of nitrones with vinyldiazoacetates catalyzed by Rh2(R-TPCP)4: mechanism and enantioselectivity." RSC Advances 6, no. 59 (2016): 53839–51. http://dx.doi.org/10.1039/c6ra07873g.

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The mechanism of Rh<sub>2</sub>(R-TPCP)<sub>4</sub>-catalyzed [3 + 2]-dipolar cycloadditions between vinyldiazoacetate and nitrone to form 2,5-dihydroisoxazole has been studied by ONIOM methodology calculations including density functional theory and PM6 theory.
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12

Pušavec, Eva, Jona Mirnik, Luka Šenica, Uroš Grošelj, Branko Stanovnik, and Jurij Svete. "Cu(I)-catalyzed [3+2] Cycloadditions of tert-Butyl (S)-(3-Oxopent-4- yn-2-yl)carbamate to 1-Benzylidenepyrazole-3-one-derived Azomethine Imines." Zeitschrift für Naturforschung B 69, no. 5 (2014): 615–26. http://dx.doi.org/10.5560/znb.2014-4011.

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Parallel screening of suitable reaction conditions for Cu(I)-catalyzed [3+2] cycloadditions of (1Z,4R*,5R*)-4-benzoylamino-1-benzylidene-5-phenyl-3-oxopyrazolidin-1-ium-2-ide (1a) to methyl propiolate (2) has established that this reaction proceeds smoothly at room temperature in acetonitrile in the presence of CuI and Hünig’s base. The optimized reaction conditions were then applied in regio- and stereo-selective 1,3-dipolar cycloadditions of racemic azomethine imines 1a-e to tert-butyl (S)-(3-oxopent-4-yn-2-yl)carbamate (6) leading to mixtures of diastereomeric non-racemic chromatographicall
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13

Wang, Lianjie, Charlie Verrier, Mohammed Ahmar, and Yves Queneau. "Dipolar cycloadditions of HMF-based nitrones: stepwise and multicomponent reactions, stereochemical outcome and structural scope." Green Chemistry 22, no. 22 (2020): 7907–12. http://dx.doi.org/10.1039/d0gc03004j.

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14

Adembri, Giorgio, M. Laura Paoli, and Alessandro Sega. "Influence of the Solvent on the stereoselectivity of 1,3-Dipolar cycloaddition of Nitrile Oxides on Several 4-Substituted 2-Cyclopentenones." Journal of Chemical Research 2003, no. 3 (2003): 126–27. http://dx.doi.org/10.3184/030823403103173453.

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The diastereofacial selectivity in 1,3-dipolar cycloadditions of 2,6-dichlorobenzonitrile oxide on 2-cyclopentenones 1–5 is strongly dependent on the solvent when an hydroxyl group is present at C(4) (1–2) while if this group is protected (3–4) or absent (5) the reaction is solvent independent.
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15

Kissane, Marie, Simon E. Lawrence, and Anita R. Maguire. "1,3-Dipolar cycloadditions of 2-thio-3-chloroacrylamides with diazoalkanes." Organic & Biomolecular Chemistry 8, no. 12 (2010): 2735. http://dx.doi.org/10.1039/c002479a.

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16

BALDWIN, J. E., and J. PITLIK. "ChemInform Abstract: 1,3-Dipolar Cycloadditions of 3-Methylenecephams with Diazoalkanes." ChemInform 22, no. 7 (2010): no. http://dx.doi.org/10.1002/chin.199107266.

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17

BANERJI, A., J. BANERJI, S. HALDAR, et al. "ChemInform Abstract: 1,3-Dipolar Cycloadditions. Part 3. Cycloaddition of C,N-Diarylnitrones to N-Cinnamoylpiperidines." ChemInform 29, no. 38 (2010): no. http://dx.doi.org/10.1002/chin.199838133.

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18

Cardoso, Ana L., and Maria I. L. Soares. "1,3-Dipolar Cycloadditions Involving Allenes: Synthesis of Five-Membered Rings." Current Organic Chemistry 23, no. 27 (2020): 3064–134. http://dx.doi.org/10.2174/1385272823666191203122959.

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The 1,3-dipolar cycloaddition reaction is a powerful and versatile strategy for the synthesis of carbocyclic and heterocyclic five-membered rings. Herein, the most recent developments on the [3+2] cycloaddition reactions using allenes acting either as dipolarophiles or 1,3-dipole precursors, are highlighted. The recent contributions on the phosphine- and transition metal-catalyzed [3+2] annulations involving allenes as substrates are also covered, with the exception of those in which the formation of a 1,3-dipole (or synthetic equivalent) is not invoked. This review summarizes the most relevan
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19

Bastrakov, Maxim A., Alexey K. Fedorenko, Alexey M. Starosotnikov та Alexander Kh Shakhnes. "Nitropyridines as 2π-Partners in 1,3-Dipolar Cycloadditions with N-Methyl Azomethine Ylide: An Easy Access to Condensed Pyrrolines". Molecules 26, № 18 (2021): 5547. http://dx.doi.org/10.3390/molecules26185547.

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1,3-Dipolar cycloaddition reactions of 2-substituted 5-R-3-nitropyridines and isomeric 3-R-5-nitropyridines with N-methyl azomethine ylide were studied. The effect of the substituent at positions 2 and 5 of the pyridine ring on the possibility of the [3+2]-cycloaddition process was revealed. A number of new derivatives of pyrroline and pyrrolidine condensed with a pyridine ring were synthesized.
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20

Peng, Chuqin, Jiwei Ren, Jun-An Xiao, Honggang Zhang, Hua Yang, and Yiming Luo. "Additive-assisted regioselective 1,3-dipolar cycloaddition of azomethine ylides with benzylideneacetone." Beilstein Journal of Organic Chemistry 10 (February 7, 2014): 352–60. http://dx.doi.org/10.3762/bjoc.10.33.

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1,3-Dipolar cycloadditions of isatins, benzylamine and benzylideneacetones were studied to prepare a series of novel spiropyrrolidine-oxindoles – 4′-acetyl-3′,5′-diarylspiro[indoline-3,2′-pyrrolidin]-2-ones and 3′-acetyl-4′,5′-diarylspiro[indoline-3,2′-pyrrolidine]-2-ones in good yields of up to 94% and with good regioselectivities. Regioselectivities are reversible by the addition of water or 4-nitrobenzoic acid, respectively. The substituent effects on the regioselectivity were also investigated.
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21

Zbancioc, Gheorghita N., Maria C. Caprosu, Costel C. Moldoveanu, and Ionel I. Mangalagiu. "Structure, liquid and solid state synthesis for dimers via [3+3] dipolar cycloadditions." Arkivoc 2005, no. 10 (2005): 189–98. http://dx.doi.org/10.3998/ark.5550190.0006.a16.

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22

Avijit, Banerji, and Bandyopadhyay Debasish. "Recent advances in the 1,3-dipolar cycloaddition reactions of nitrones." Journal of Indian Chemical Society Vol. 81, Oct 2004 (2004): 817–32. https://doi.org/10.5281/zenodo.5832421.

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Centre of Advanced Studies on Natural Products, Department of Chemistry, Calcutta University, 92, A. P. C. Road, Kolkata-700 009, India E-mail: ablabcu@yahoo.co.uk&nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp;<em> Fax</em> : 91-33-23519755 <em>Manuscript received 3 April 2003, revised 31 May 2004, accepted 11 June 2004</em> This review outlines some recent developments in 1,3-dipolar cycloadditions of nitrones. An attempt has been made to focus on aspects which were comparatively less revealed earlier. Special emphasis has been given on reactions and their explanation on mechanistic and theo
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23

Pezdirc, Lidija, Branko Stanovnik, and Jurij Svete. "1,3-Dipolar cycloadditions of 5-(4-methoxyphenyl)- and 5-(1H-indol-3-yl)-substituted (1Z,4R*,5R*)-1-(arylmethylidene)-4-benzamido-3-oxopyrazolidin-1-ium-2-ides to olefinic dipolarophiles." Collection of Czechoslovak Chemical Communications 74, no. 5 (2009): 835–56. http://dx.doi.org/10.1135/cccc2009011.

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1,3-Dipolar cycloadditions of (1Z,4R*,5R*)-1-(arylmethylidene)-4-benzamido-5-(4-methoxyphenyl)-3-oxopyrazolidin-1-ium-2-ides 6a–6f and their 5-(1H-indol-3-yl) analogues 6g–6j to olefinic dipolarophiles 7–9 were studied. Stereochemistry was controlled by the structure of dipoles 6 and dipolarophiles 7–9. Reactions of ortho-unsubstituted dipoles 6a–6c, 6g gave the major isomers 10 and 14 with syn-oriented protons H-3 and H-5, whilst ortho-disubstituted dipoles 6d, 6e, 6j gave cycloadducts 11 and 12 with anti-oriented protons H-3 and H-5. In comparison with their 5-phenyl-substituted analogues, d
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24

Guolin, Zhang, and Hu Yongzhou. "Regioselection in 1,3-Dipolar Cycloadditions of 3-Methylpyridine N-Imide to Aromatic Carbonitriles. Synthesis of 2-Aryl-8-Methyl[1,2,4]Triazolo [1,5-a]Pyridines." Journal of Chemical Research 2002, no. 11 (2002): 560–61. http://dx.doi.org/10.3184/030823402103170763.

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1-Amino-3-methylpyridinium mesitylenesulfonate (3) reacts with aromatic nitriles in the presence of potassium hydroxide, undergoing 1,3-dipolar cycloaddition followed by elimination of H2 to give 2-aryl-8-methyl[1,2,4]triazolo[1,5- a]pyridines as the major products, rather than the 6-methyl isomers.
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25

Wang, Tao, Boming Shen, Xuling Chen, Qianran Wan, Peiyuan Yu, and Pengfei Li. "Organocatalytic regio- and enantioselective formal [4+2]-annulation of chiral nitrogen-containing dipoles." Chemical Synthesis 3, no. 2 (2023): 9. http://dx.doi.org/10.20517/cs.2022.44.

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Quinidine-catalyzed regio- and enantioselective formal [4 + 2]-cycloadditions of 2-(4H-benzo[d][1,3]oxazin-4-yl)acrylates with N-tosyl-2-methylenebut-3-enoates and 2-methylene-3-oxoalkanoates have been developed for the first time. The reaction features the in situ formation of chiral nitrogen-containing dipolar intermediates, a ring-opening/Michael addition/annulation cascade reaction and works well over a broad substrate scope to furnish the tetrahydroquinolines in high yields with high asymmetric induction under mild conditions.
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26

Yeh, Mou-Yung, I.-Horng Pan, Che-Ping Chuang, and Hsien-Ju Tien. "The 1,3-Dipolar Cycloadditions of 3-Arylsydnone-4-Carbonitrile Oxides with Nitriles." Journal of the Chinese Chemical Society 35, no. 6 (1988): 443–49. http://dx.doi.org/10.1002/jccs.198800067.

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27

Yeh, Mou-Yung, and Wai-Cheung Chu. "The 1,3-Dipolar Cycloadditions of 3-Arylsydnone-4-Carbonitrile Oxides with Alkenes." Journal of the Chinese Chemical Society 35, no. 6 (1988): 451–57. http://dx.doi.org/10.1002/jccs.198800068.

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28

Kissane, Marie, Simon E. Lawrence, and Anita R. Maguire. "ChemInform Abstract: 1,3-Dipolar Cycloadditions of 2-Thio-3-chloroacrylamides with Diazoalkanes." ChemInform 41, no. 46 (2010): no. http://dx.doi.org/10.1002/chin.201046119.

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29

Antoci, Vasilichia, Costel Moldoveanu, Ramona Danac, Violeta Mangalagiu, and Gheorghita Zbancioc. "Huisgen [3 + 2] Dipolar Cycloadditions of Phthalazinium Ylides to Activated Symmetric and Non-Symmetric Alkynes." Molecules 25, no. 19 (2020): 4416. http://dx.doi.org/10.3390/molecules25194416.

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We present herein a straightforward and efficient pathway for the synthesis of pyrrolophthalazine cycloadducts via Huisgen [3 + 2] dipolar cycloaddition reactions of phthalazinium ylides to methyl propiolate or dimethyl acetylenedicarboxylate (DMAD). A thoroughly comparative study concerning the efficiency of synthesis, conventional thermal heating (TH) versus microwave (MW) and ultrasound (US) irradiation, has been performed. The cycloaddition reactions of phthalazinium ylides to methyl propiolate occur regiospecific, with a single regioisomer being obtained. Under conventional TH, the cycloa
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30

Baek, Seung-yeol, Ju Young Lee, Donguk Ko, Mu-Hyun Baik, and Eun Jeong Yoo. "Rationally Designing Regiodivergent Dipolar Cycloadditions: Frontier Orbitals Show How To Switch between [5 + 3] and [4 + 2] Cycloadditions." ACS Catalysis 8, no. 7 (2018): 6353–61. http://dx.doi.org/10.1021/acscatal.8b00845.

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31

Al-Zaydi, Khadijah Mohamed, and Ebtisam Abdel Aziz Hafez. "1,3-Dipolar Cycloadditions of Some Nitrilimines and Nitrile Oxides to 3-N,N-Dimethylamino-1 -oxopropene Derivatives." Journal of Chemical Research 23, no. 6 (1999): 360–61. http://dx.doi.org/10.1177/174751989902300608.

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An efficient synthesis of some novel pyrazoles 8a-j, 13a-e, 18a,b, isoxazoles 26a-g, pyrazolo[3,4- d]pyridazines 9a-d and isoxazolo[3,4- d]pyridazines 27a-d via 1,3-dipolar cycloaddition reactions is reported.
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32

Zhu, Jin, Austin C. Durham, Yidong Wang, et al. "Regiocontrolled Coupling of Alkynes and Dipolar Reagents: Iron-Mediated [3 + 2] Cycloadditions Revisited." Organometallics 40, no. 14 (2021): 2295–304. http://dx.doi.org/10.1021/acs.organomet.1c00032.

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33

McGowin, A. E., L. Jackson, L. W. Marshall, and K. Tumbull. "1,3-DIPOLAR CYCLOADDITIONS OF 3-PHENYLSYDNONE WITH ACETYLENE DICARBOXYLATES IN SUPERCRITICAL CARBON DIOXIDE." Organic Preparations and Procedures International 33, no. 1 (2001): 100–102. http://dx.doi.org/10.1080/00304940109356581.

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34

Kissane, Marie, Simon E. Lawrence, and Anita R. Maguire. "1,3-Dipolar cycloadditions of 2-thio-3-chloroacrylamides with nitrile oxides and nitrones." Tetrahedron 66, no. 25 (2010): 4564–72. http://dx.doi.org/10.1016/j.tet.2010.04.057.

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35

Virányi, Andrea, Gabriella Marth, András Dancsó, Gábor Blaskó, László Tőke та Miklós Nyerges. "3-Nitrochromene derivatives as 2π components in 1,3-dipolar cycloadditions of azomethine ylides". Tetrahedron 62, № 37 (2006): 8720–30. http://dx.doi.org/10.1016/j.tet.2006.06.101.

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36

Nyerges, Miklós, Andrea Virányi, Gabriella Marth, András Dancsó, Gábor Blaskó та László Tőke. "3-Nitrochromene Derivatives as 2π Components in 1,3-Dipolar Cycloadditions of Azomethine Ylides". Synlett 2004, № 15 (2004): 2761–65. http://dx.doi.org/10.1055/s-2004-835655.

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37

Grafton, Mark, Andrew C. Mansfield, and M. Jonathan Fray. "[3+2] Dipolar cycloadditions of an unstabilised azomethine ylide under continuous flow conditions." Tetrahedron Letters 51, no. 7 (2010): 1026–29. http://dx.doi.org/10.1016/j.tetlet.2009.12.071.

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38

Bassett, Kimberley C., Fei You, Peter M. Graham, William H. Myers, Michal Sabat та W. Dean Harman. "Furan [3 + 2] Dipolar Cycloadditions Promoted by a π-Basic Tungsten Metal Fragment". Organometallics 25, № 2 (2006): 435–39. http://dx.doi.org/10.1021/om0506926.

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39

Kalluraya, Balakrishna, Kaushik B R, and H. M. Somashekarappa. "Effect of Gamma- Irradiation on Structure, Morphology and Thermal Properties of Novel Polyamide Based Thermoset Obtained by Double Cycloaddition." Journal of Modern Materials 7, no. 1 (2020): 17–25. http://dx.doi.org/10.21467/jmm.7.1.17-25.

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Cycloaddition reactions gained prominence in macromolecular chemistry for generating macromolecules because of high yields of these reactions, which is a key tool that drives polyaddition reactions. Cycloaddition reaction plays major role in extension of polymerisation or in other words high conversions of monomers to macromolecules of high molecular weights. Until the late 1990s, the major studies regarding cycloadditions in novel polymer synthesis were related to polyaddition reactions. Since then in the field of polymer synthesis the affirmative strengths of these cycloaddition reactions ha
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40

Zhang, Xiaofeng, Kenny Pham, Shuai Liu, et al. "Stereoselective synthesis of fused tetrahydroquinazolines through one-pot double [3 + 2] dipolar cycloadditions followed by [5 + 1] annulation." Beilstein Journal of Organic Chemistry 12 (October 18, 2016): 2204–10. http://dx.doi.org/10.3762/bjoc.12.211.

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The one-pot [3 + 2] cycloaddition of an azomethine ylide with a maleimide followed by another [3 + 2] cycloaddition of an azide with the second maleimide gives a 1,5-diamino intermediate which is used for a sequential aminomethylation reaction with formaldehyde through [5 + 1] annulation to afford a novel polycyclic scaffold bearing tetrahydroquinazoline, pyrrolidine, pyrrolidinedione, and N-substituted maleimide in stereoselective fashion.
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41

Filatov, Alexander S., Olesya V. Khoroshilova, Anna G. Larina, Vitali M. Boitsov, and Alexander V. Stepakov. "Synthesis of bis-spirocyclic derivatives of 3-azabicyclo[3.1.0]hexane via cyclopropene cycloadditions to the stable azomethine ylide derived from Ruhemann's purple." Beilstein Journal of Organic Chemistry 18 (June 29, 2022): 769–80. http://dx.doi.org/10.3762/bjoc.18.77.

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A reliable method for the synthesis of bis-spirocyclic derivatives of 3-azabicyclo[3.1.0]hexanes through the 1,3-dipolar cycloaddition (1,3-DC) reactions of cyclopropenes to the stable azomethine ylide – protonated form of Ruhemann's purple (PRP) has been developed. Both 3-substituted and 3,3-disubstituted cyclopropenes reacted with PRP, affording the corresponding bis-spirocyclic 3-azabicyclo[3.1.0]hexane cycloadducts in moderate to good yields with high diastereofacial selectivity. Moreover, several unstable 1,2-disubstituted cyclopropenes were successfully trapped by the stable 1,3-dipole u
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42

Sakamoto, Masanori, Osamu Tamura, Naka Mita, et al. "1,3-Dipolar Cycloadditions of a-Methoxy-carbonylnitrones in the Presence of Eu(fod)3." HETEROCYCLES 46, no. 1 (1997): 95. http://dx.doi.org/10.3987/com-97-s36.

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43

W. Gribble, Gordon, and Justin M. Lopchuk. "Synthesis of 2- and 3-Indolylpyrroles via 1,3-Dipolar Cycloadditions of Münchnones and Nitroalkenes." HETEROCYCLES 82, no. 2 (2010): 1617. http://dx.doi.org/10.3987/com-10-s(e)125.

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44

Luis García Ruano, José, Alberto Fraile, Alberto Núñez, M. Rosario Martín, and Inés Alonso. "C-[o-(p-Tolyl)sulfinyl]phenylnitrones. Synthesis and Reactivity in [3+2] Dipolar Cycloadditions." HETEROCYCLES 84, no. 2 (2012): 913. http://dx.doi.org/10.3987/com-11-s(p)72.

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45

Diaz-Velandia, John, Natalia Durán-Díaz, Jorge Robles-Camargo, and Alix Elena Loaiza. "Síntesis y evaluación “in vitro” de la actividad antifúngica de oximas, éteres de oxima e isoxazoles." Universitas Scientiarum 16, no. 3 (2011): 294. http://dx.doi.org/10.11144/javeriana.sc16-3.saiv.

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&lt;p&gt;&lt;strong&gt;&lt;/strong&gt;&lt;strong&gt;Objective&lt;/strong&gt;. To synthesize and carry out a preliminary evaluation of the &lt;em&gt;in vitro&lt;/em&gt; antifungal activity of oximes, oxime ethers and isoxazoles. &lt;strong&gt;Materials and methods&lt;/strong&gt;. Oximes were synthesized from aldehydes or ketones with NH&lt;sub&gt;2&lt;/sub&gt;OH.HCl and K&lt;sub&gt;2&lt;/sub&gt;CO&lt;sub&gt;3&lt;/sub&gt;. Oxime ethers were prepared by alkylation of oximes with propargyl bromide or 2-bromobenzyl bromide, using NaOH as base and acetone as solvent. The isoxazoles were obtained by
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46

Victoria Martin-Ramos, M., Francisco Fariña, and Magali Romañach. "1,3-Dipolar Cycloadditions of an Aziridine via Azomethine Ylide to 2-Methylpyridazin-3(2H)-ones." HETEROCYCLES 40, no. 1 (1995): 379. http://dx.doi.org/10.3987/com-94-s47.

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47

Bahule, B. B. "Synthesis of Pyrazolidines (5-membered heterocyclic rings) through 1, 3- dipolar cycloadditions of azomethine imines." IOSR Journal of Applied Chemistry 2, no. 6 (2012): 39–40. http://dx.doi.org/10.9790/5736-0263940.

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48

Sanders, Brian C., Frédéric Friscourt, Petr A. Ledin, et al. "Metal-Free Sequential [3 + 2]-Dipolar Cycloadditions using Cyclooctynes and 1,3-Dipoles of Different Reactivity." Journal of the American Chemical Society 133, no. 4 (2011): 949–57. http://dx.doi.org/10.1021/ja1081519.

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49

Nyerges, Miklós. "2-Oxoindolin-3-ylidene Derivatives as 2π Components in 1,3-Dipolar Cycloadditions of Azomethine Ylides". Synlett 1999, № 1 (1999): 111–13. http://dx.doi.org/10.1055/s-1999-2525.

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50

Burdisso, Marina, Anna Gamba, Remo Gandolfi та Paolo Pevarello. "Stereospecificity of 1,.3-dipolar cycloadditions of cyclic nitrones to (E) and (Z)-β-nitrostyrenes". Tetrahedron 43, № 8 (1987): 1835–46. http://dx.doi.org/10.1016/s0040-4020(01)81495-2.

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