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Relevant bibliographies by topics / 3-glutathionyl-1

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Academic literature on the topic '3-glutathionyl-1'

Author: Grafiati

Published: 14 March 2023

Last updated: 31 July 2025

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Journal articles on the topic "3-glutathionyl-1"

1

Hong, J. L., L. F. Liu, L. Y. Wang, et al. "Modification of glutathione S-transferase 3-3 mutants with 2-(S-glutathionyl)-3,5,6-trichloro-1,4-benzoquinone. Identification of the C-terminal tryptic fragment as part of the H-site and evidence that 2-(S-glutathionyl)-3,5,6-trichloro-1,4-benzoquinone is not specific for cysteine labelling." Biochemical Journal 304, no. 3 (1994): 825–31. http://dx.doi.org/10.1042/bj3040825.

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A triple mutant of rat liver glutathione S-transferase 3-3 that has all three cysteine residues replaced with serine (CallS) and a quadruple mutant with a Tyr-115 to phenylalanine substitution on CallS (CallSY115F) were reacted with 2-(S-glutathionyl)-3,5,6-trichloro-1,4-benzoquinone (GS-1,4-TCBQ). The modified proteins were analysed on a triple-quadrupole mass spectrometer equipped with an electrospray ionization source. At an enzyme: GS-1,4-TCBQ ratio of 1:10, the enzymes were modified at multiple sites. Covalent attachment of a single inhibitor on to the protein was achieved by lowering the

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van Hylckama Vlieg, Johan E. T., Jaap Kingma, Wim Kruizinga, and Dick B. Janssen. "Purification of a GlutathioneS-Transferase and a Glutathione Conjugate-Specific Dehydrogenase Involved in Isoprene Metabolism in Rhodococcussp. Strain AD45." Journal of Bacteriology 181, no. 7 (1999): 2094–101. http://dx.doi.org/10.1128/jb.181.7.2094-2101.1999.

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ABSTRACT A glutathione S-transferase (GST) with activity toward 1,2-epoxy-2-methyl-3-butene (isoprene monoxide) andcis-1,2-dichloroepoxyethane was purified from the isoprene-utilizing bacterium Rhodococcus sp. strain AD45. The homodimeric enzyme (two subunits of 27 kDa each) catalyzed the glutathione (GSH)-dependent ring opening of various epoxides. At 5 mM GSH, the enzyme followed Michaelis-Menten kinetics for isoprene monoxide and cis-1,2-dichloroepoxyethane, withV max values of 66 and 2.4 μmol min−1 mg of protein−1 andKm values of 0.3 and 0.1 mM for isoprene monoxide and cis-1,2-dichloroepo

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SPENCER, Jeremy P. E., Gunter G. C. KUHNLE, Robert J. WILLIAMS, and Catherine RICE-EVANS. "Intracellular metabolism and bioactivity of quercetin and its in vivo metabolites." Biochemical Journal 372, no. 1 (2003): 173–81. http://dx.doi.org/10.1042/bj20021972.

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Understanding the cellular effects of flavonoid metabolites is important for predicting which dietary flavonoids might be most beneficial in vivo. Here we investigate the bioactivity in dermal fibroblasts of the major reported in vivo metabolites of quercetin, i.e. 3′-O-methyl quercetin, 4′-O-methyl quercetin and quercetin 7-O-β-d-glucuronide, relative to that of quercetin, in terms of their further metabolism and their resulting cytotoxic and/or cytoprotective effects in the absence and presence of oxidative stress. Uptake experiments indicate that exposure to quercetin led to the generation

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4

Lundström-Ljung, Johanna, Alexios Vlamis-Gardikas, Fredrik Åslund, and Arne Holmgren. "Reactivity of glutaredoxins 1, 2 and 3 from Escherichia coli and protein disulfide isomerase towards glutathionyl-mixed disulfides in ribonuclease A." FEBS Letters 443, no. 2 (1999): 85–88. http://dx.doi.org/10.1016/s0014-5793(98)01698-6.

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van Hylckama Vlieg, Johan E. T., Hans Leemhuis, Jeffrey H. Lutje Spelberg, and Dick B. Janssen. "Characterization of the Gene Cluster Involved in Isoprene Metabolism in Rhodococcus sp. Strain AD45." Journal of Bacteriology 182, no. 7 (2000): 1956–63. http://dx.doi.org/10.1128/jb.182.7.1956-1963.2000.

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ABSTRACT The genes involved in isoprene (2-methyl-1,3-butadiene) utilization in Rhodococcus sp. strain AD45 were cloned and characterized. Sequence analysis of an 8.5-kb DNA fragment showed the presence of 10 genes of which 2 encoded enzymes which were previously found to be involved in isoprene degradation: a glutathioneS-transferase with activity towards 1,2-epoxy-2-methyl-3-butene (isoI) and a 1-hydroxy-2-glutathionyl-2-methyl-3-butene dehydrogenase (isoH). Furthermore, a gene encoding a second glutathioneS-transferase was identified (isoJ). TheisoJ gene was overexpressed in Escherichia col

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Roman, Tomas, Loris Tonidandel, Giorgio Nicolini, et al. "Evidence of the Possible Interaction between Ultrasound and Thiol Precursors." Foods 9, no. 1 (2020): 104. http://dx.doi.org/10.3390/foods9010104.

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The effect of ultrasound (20 kHz, 153 μm) on the prefermentation extraction mechanisms in Sauvignon Blanc grapes was studied, focusing on 3-mercaptohexan-1-ol (3MH) and 4-mercapto-4-methyl-pentan-2-one (4MMP) precursors linked to glutathione (GSH) and cysteine (Cys). The treatment determined a positive extraction trend between the duration (untreated, 3 and 5 min) and the conductivity or the concentration of catechins and total phenols, significantly differentiated after 5 min. Nevertheless, the concentration of the thiol precursors in grape juice not only remained undifferentiated, but that o

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HANSSON, Lars O., Mikael WIDERSTEN, and Bengt MANNERVIK. "An approach to optimizing the active site in a glutathione transferase by evolution in vitro." Biochemical Journal 344, no. 1 (1999): 93–100. http://dx.doi.org/10.1042/bj3440093.

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A glutathione transferase (GST) mutant with four active-site substitutions (Phe10 → Pro/Ala12 → Trp/Leu107 → Phe/Leu108 → Arg) (C36) was isolated from a library of active-site mutants of human GST A1-1 by the combination of phage display and mechanism-based affinity adsorption [Hansson, Widersten and Mannervik (1997) Biochemistry 36, 11252-11260]. C36 was selected on the basis of its affinity for the transition-state analogue 1-(S-glutathionyl)-2,4,6-trinitrocyclohexadienate. C36 affords a 105-fold rate enhancement over the uncatalysed reaction between reduced glutathione and 1-chloro-2,4-dini

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Gorbunov, N. V., N. M. Elsayed, E. R. Kisin, A. V. Kozlov, and V. E. Kagan. "Air blast-induced pulmonary oxidative stress: interplay among hemoglobin, antioxidants, and lipid peroxidation." American Journal of Physiology-Lung Cellular and Molecular Physiology 272, no. 2 (1997): L320—L334. http://dx.doi.org/10.1152/ajplung.1997.272.2.l320.

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Blast overpressure (BOP) is a phenomenon that describes the instantaneous rise in atmospheric pressure above ambient, resulting from the firing of large caliber weapons or from military or civilian explosions. Exposure to BOP results in injury to the gas-filled organs, such as the lungs, which exhibit a contusion-type injury. We examined the effects of BOP in rats at 5 and 60 min after exposure to a low-level BOP (62 +/- 3 kPa). The exposure was found to cause oxidative stress in the lung that was characterized by 1) a 3.5-fold decrease in total antioxidant reserves, 2) a depletion of the majo

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Phan, Nhan Phuoc Hoai, Van Thi Bich Pham, Tu Dang Quoi Phan, Tuyen Nguyen Kim Pham, and Hao Minh Hoang. "Cytotoxic activities of synthesized curcumin and 3,4-Difluorinated curcumin against HepG2, LU-1 and KB cancer cell lines." Science and Technology Development Journal 23, no. 4 (2020): 781–87. http://dx.doi.org/10.32508/stdj.v23i4.2464.

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Introduction: Natural curcuminoids isolated from turmeric (Curcuma longa L.) have been limited in number and the amount of substrates evaluated in semi-synthetic processes and biological tests. Currently, potent anticancer activities of curcuminoids have garnered increased attention such that a greater number of synthetic procedures of curcumin analogues have been developed for further biological evaluations. The fluorine substituent of fluorinated compounds is important for biological responses. However, natural products bearing fluorine have rarely been found. In the study herein, we employe

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Chowdhury, Uttam. "Selenium (Se) as well as mercury (Hg) may influence the methylation and toxicity of inorganic arsenic, but further research is needed with combination of Inorg-arsenic, Se, and Hg." Journal of Toxicology and Environmental Sciences 1, no. 1 (2021): 1–8. http://dx.doi.org/10.55124/jtes.v1i1.46.

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Our studies have indicated that the relative concentration of Se or Hg to As in urine and blood positively correlates with percentage of inorganic arsenic (% Inorg-As) and percentage of monomethlyarsonic acid [% MMA (V)]. We also found a negative correlation with percentage of dimethylarsinic acid [% DMA (V)] and the ratio of % DMA (V) to % MMA (V). In another study, we found that a group of proteins were significantly over expressed and conversely other groups were under-expressed in tissues in Na-As (III) treated hamsters. Introduction.Inorganic arsenic (Inorg-As) in drinking water.One

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Dissertations / Theses on the topic "3-glutathionyl-1"

1

ROTONDO, ROSSELLA. "New enzymatic pathway(s) in 4-hydroxynonenal metabolism." Doctoral thesis, Università di Siena, 2017. http://hdl.handle.net/11365/1007903.

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The main effect of lipid peroxidation, which often occurs in response to oxidative stress, is the production of different toxic aldehydes. In particular, over the years, the lipid peroxidation-derived aldehyde 4-hydroxy-trans-2-nonenal (HNE) has received much attention for its dual role in the pathogenesis of several diseases and as signaling molecule. HNE metabolism is reported to mainly occur through its conjugation with glutathione (GSH) and the subsequent formation of 3-glutathionyl-4-hydroxynonanal (GSHNE) [1, 2]. This molecule is susceptible to both oxidative and reductive transformation

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