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Journal articles on the topic '3-hydroxypyridine derivatives'

Author: Grafiati

Published: 4 June 2025

Last updated: 1 August 2025

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1

Den Hertog, H. J., F. R. Schepman, J. de Bruyn, and G. J. E. Thysse. "Bromo-derivatives of 3-hydroxypyridine." Recueil des Travaux Chimiques des Pays-Bas 69, no. 10 (2010): 1281–88. http://dx.doi.org/10.1002/recl.19500691011.

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2

Yasnetsov, V. V., Yu V. Ivanov, Vik V. Yasnetsov, S. К. Karsanova, and N. А. Chelnaya. "NEUROPROTECTIVE PROPERTIES OF NEW 3-HYDROXYPYRIDINE DERIVATIVES." Aerospace and Environmental Medicine 53, no. 1 (2019): 74–78. http://dx.doi.org/10.21687/0233-528x-2019-53-1-74-78.

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3

Lukyanova, L. D., E. L. Germanova, T. A. Tsybina, and G. N. Chernobaeva. "Energotropic Effect of Succinate-Containing Derivatives of 3-Hydroxypyridine." Bulletin of Experimental Biology and Medicine 148, no. 4 (2009): 587–91. http://dx.doi.org/10.1007/s10517-010-0771-0.

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4

Zolotov, N. N., L. D. Smirnov, V. I. Kuz'min, et al. "Derivatives of 3-hydroxypyridine as inhibitors of proteolytic enzymes." Pharmaceutical Chemistry Journal 23, no. 2 (1989): 89–91. http://dx.doi.org/10.1007/bf00764451.

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5

Nesterova, Natalia I., Olesya V. Shcheblykina, Pavel D. Kolesnichenko, Arkady V. Nesterov, Dmitry V. Shcheblykin, and Dmitry Yakovlev. "Neuroprotective effects of taurine and 3-hydroxypyridine derivatives in the intracerebral hemorrhage model in rats." Research Results in Pharmacology 5, no. (3) (2019): 87–94. https://doi.org/10.3897/rrpharmacology.5.36988.

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Introduction: At present, the problem of pharmacological correction of free radical processess emerges full-blown. The aim of the study is an experimental study of the neuroprotective effect of taurine and 3-hydroxypyridine derivatives. Materials and methods: The study was performed in Wistar rats. The neuroprotective effect of the substances was studied in the intracerebral hemorrhage model. Results and discussion: The administration of the studied substances had a positive effect on the survival of the animals within the first day (50% of rats died in the control group, 30% – in the Mexidol-

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6

Val'dman, A. V., T. A. Voronina, L. D. Smirnov, U. M. Tilekeeva, and K. M. Kyumaev. "Effect of 3-hydroxypyridine derivatives on the central nervous system." Bulletin of Experimental Biology and Medicine 99, no. 1 (1985): 73–75. http://dx.doi.org/10.1007/bf00806617.

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7

Danilenko, A. P., K. S. Trunov, M. V. Pokrovsky, et al. "Protective role of 3-oxypyridine derivatives in rats’ steroid-induced osteoporosis associated with reduced oxidative stress and recovery of nitric oxide formation." Pharmacy & Pharmacology 11, no. 1 (2023): 48–61. http://dx.doi.org/10.19163/2307-9266-2023-11-1-48-61.

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From the point of view of the mechanisms for the implementation of pathogenetic links in the development of steroid-induced osteoporosis considered in the paper, the increased risk of the oxidative stress in osteoblasts, as well as the development of the vessels endothelial dysfunction of the microcirculatory bloodstream in the bone tissue, are of particular interest. They lead to the impaired bone tissue trophism and progression of osteoporosis.The aim of the study was research of the osteoprotective effects of a 3-hydroxypyridine derivatives composition on the model of steroid-induced osteop

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8

Nurkenov, O. A., S. D. Fazylov, T. M. Seilkhanov, Zh Nurmaganbetov, A. M. Gazaliev, and G. Zh Karipova. "Synthesis and structure of thiourea derivatives of functionally substituted pyridines." Bulletin of the Karaganda University. "Chemistry" series 101, no. 1 (2021): 4–11. http://dx.doi.org/10.31489/2021ch1/4-11.

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The article presents data on the synthesis and study of the structure of thiourea derivatives of functionally substituted pyridines. New thiourea derivatives containing a pharmacologically active pyridine moiety in their structure were obtained. As the starting synton, 2-amino-5-bromopyridine, 2-amino-3-hydroxypyridine and 2-aminomethylpyridine were selected. It was shown that the interaction of 2-amino-5-bromopyridine, 2-amino-3-hydroxypyridine and 2-aminomethylpyridine with ethyl and phenylisothiocyanates in ethanol leads to the formation of the corresponding pyridine-containing thioureas. T

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9

Luk'yanova, L. D., R. E. Atabaeva, and S. Yu Shepeleva. "Antihypoxic effects of some 3-hydroxypyridine derivatives in isolated rat myocardium." Bulletin of Experimental Biology and Medicine 115, no. 4 (1993): 384–86. http://dx.doi.org/10.1007/bf00850908.

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10

Yakunin, Ya Yu, V. D. Dyachenko, and V. P. Litvinov. "Synthesis of 3-cyano-5-ethoxycarbonyl-6-hydroxypyridine-2-thiol derivatives." Russian Chemical Bulletin 48, no. 1 (1999): 195–96. http://dx.doi.org/10.1007/bf02494427.

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11

Yasnetsov, Vik V., D. E. Kaurova, E. Yu Bersenev, and S. Ya Skachilova. "INVESTIGATION OF THE ANTIHYPOXIC PROPERTIES OF NEW NICOTINIC ACID DERIVATIVES." Aerospace and Environmental Medicine 54, no. 5 (2020): 73–76. http://dx.doi.org/10.21687/0233-528x-2020-54-5-73-76.

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Two of the five new nicotinic acid derivatives proved to have the antihypoxic properties in tests with mice exposed to acute normobaric hypoxic hypoxia with hypercapnia. Specifically, LKhT 4–19 (100 mg/kg) extended lifetime of the animals by 11 %; LKhT 6-19 doses of 50 and 100 mg/kg extended lifetime by 23 and 34 %, respectively. The antihypoxic effect of LKhT 6–19 (50 mg/kg) outperformed in 1.2 times mexidol (substance of comparison) at the similar dose and was highly competitive at the dose of 100 mg/kg. For reference, mexidol is a 3-hydroxypyridine derivative (ethylmethylhydroxypyridine suc

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12

Stratienko, Elena N., Natalia P. Katunina, Fatima N. Tseeva, et al. "COMPARATIVE ANALYSIS OF ACTOPROTECTIVE PROPERTIES OF NEW CHEMICAL COMPOUNDS." Kuban Scientific Medical Bulletin 26, no. 2 (2019): 122–29. http://dx.doi.org/10.25207/1608-6228-2019-26-2-122-129.

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Aim. This study was aimed at searching and investigating new substances among phenylethyl derivatives of 3-hydroxypyridine, which exhibit a high actoprotective activity under the conditions of normoxia and acute hypobaric hypoxia.Materials and methods. New compounds of phenylethyl derivatives of 3-hydroxypyridine under the SC code (n = 23) were investigated in comparison with bemethyl and bromantane. The actoprotective activity of new compounds was assessed in experimental animals using a treadmill running test under the conditions of normoxia and acute hypobaric hypoxia. The studied chemical

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13

Nesterova, Natalia I., Olesya V. Shcheblykina, Pavel D. Kolesnichenko, Arkady V. Nesterov, Dmitry V. Shcheblykin, and Dmitry Yakovlev. "Neuroprotective effects of taurine and 3-hydroxypyridine derivatives in the intracerebral hemorrhage model in rats." Research Results in Pharmacology 5, no. 3 (2019): 87–94. http://dx.doi.org/10.3897/rrpharmacology.5.36988.

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Introduction: At present, the problem of pharmacological correction of free radical processess emerges full-blown. The aim of the study is an experimental study of the neuroprotective effect of taurine and 3-hydroxypyridine derivatives. Materials and methods: The study was performed in Wistar rats. The neuroprotective effect of the substances was studied in the intracerebral hemorrhage model. Results and discussion: The administration of the studied substances had a positive effect on the survival of the animals within the first day (50% of rats died in the control group, 30% – in the Mexidol-

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14

Solovev, N. V. "Possibility of pharmacological correction of NMDA-induced retinal excitotoxicity by 3-hydroxypyridine derivatives." Modern technologies in ophtalmology, no. 2 (May 29, 2023): 64–70. http://dx.doi.org/10.25276/2312-4911-2023-2-64-70.

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Relevance. Glaucoma is the leading cause of blindness worldwide. Among all pathological mechanisms, a special role is assigned to glutamate excitotoxicity, which accompanies a number of pathological conditions of the retina. The aim of this work was to study the pharmacological activity of compounds of 3-hydroxypyridine derivatives in a model of NMDA-induced retinal degeneration. Material and methods. The introduction of the compounds was carried out in the prophylactic mode of administration. 7 days after the model, ophthalmoscopic changes in the fundus and the level of microcirculation were

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15

Shcheblykina, Olesya V., Dmitry V. Shcheblykin, Konstantin S. Trunov, Anton P. Danilenko, and Vladimir S. Lipatov. "Experimental study of new derivatives of 3-hydroxypyridine as pharmacological agents for the correction of ischemic brain injury after intracerebral hemorrhage." Research Results in Pharmacology 8, no. (1) (2022): 71–83. https://doi.org/10.3897/rrpharmacology.8.80378.

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Introduction: Limiting the action of secondary injury factors can improve the prognosis in acute cerebral accidents. The aim of the investigation is to study the neuroprotective effects of 3-hydroxypyridine derivatives. Materials and methods: The study was performed in Wistar rats. An intracerebral hemorrhage (ICH) model was used. The animals were once administered intraperitoneally with the test drugs 1 hour before the surgery and on the 1<sup>st</sup>, 2<sup>nd</sup> and 3<sup>rd</sup> days. The registration of behaviors and condition of the animals on days 1, 3, 7 and 14 and the morphologic

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16

Peng, Dong, Dalong Cong, Kaiqiang Song, et al. "Mirror-like Bright Al-Mn Coatings Electrodeposition from 1-Ethyl-3 Methylimidazolium Chloride-AlCl3-MnCl2 Ionic Liquids with Pyridine Derivatives." Materials 14, no. 20 (2021): 6226. http://dx.doi.org/10.3390/ma14206226.

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The effects of three pyridine derivative additives, 4-hydroxypyridine, 4-picolinic acid, and 4-cyanopyridine, on Al-Mn coatings were investigated in 1-ethyl-3-methylimidazolium chloride-AlCl3-MnCl2 (EMIC-AlCl3-MnCl2) ionic liquids. The smooth mirror-like bright Al-Mn coatings were obtained only in the EMIC-AlCl3-MnCl2 ionic liquids containing 4-cyanopyridine, while the matte Al-Mn coatings were electrodeposited from EMIC-AlCl3-MnCl2 without additives or containing either 4-hydroxypyridine or 4-picolinic acid. The scanning electron microscope and X-ray diffraction showed that the bright Al-Mn c

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17

Yasnetsov, V. V., S. K. Karsanova, Vik V. Yasnetsov, Yu V. Ivanov, V. G. Motin, and N. A. Chelnaya. "ACTION OF NEW 3-HYDROXYPYRIDINE DERIVATIVES WITH ANTI-NAUPATHIA PROPERTIES ON CENTRAL NEURONS." Aerospace and Environmental Medicine 50, no. 6 (2016): 59–63. http://dx.doi.org/10.21687/0233-528x-2016-50-6-59-63.

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18

Yasnetsov, V. V., V. G. Motin, Vik V. Yasnetsov, S. K. Karsanova, Yu V. Ivanov, and N. A. Chelnaya. "STUDY OF THE ANTI-AMNESIA ACTION OF NEW 3-HYDROXYPYRIDINE DERIVATIVES IN ANIMALS." Aerospace and Environmental Medicine 52, no. 1 (2018): 62–67. http://dx.doi.org/10.21687/0233-528x-2018-52-1-62-67.

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19

Iksanova, Alfiya G., Raylya R. Gabbasova, Tatyana V. Kupriyanova, et al. "In-vitro antitumor activity of new quaternary phosphonium salts, derivatives of 3-hydroxypyridine." Anti-Cancer Drugs 29, no. 7 (2018): 682–90. http://dx.doi.org/10.1097/cad.0000000000000642.

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20

Volchegorskii, I. A., I. Yu Miroshnichenko, L. M. Rassokhina, et al. "Comparative Analysis of the Anxiolytic Effects of 3-Hydroxypyridine and Succinic Acid Derivatives." Bulletin of Experimental Biology and Medicine 158, no. 6 (2015): 756–61. http://dx.doi.org/10.1007/s10517-015-2855-3.

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21

Volchegorskii, I. A., I. Yu Miroshnichenko, L. M. Rassokhina, et al. "The Antidepressant Actions of 3-Hydroxypyridine and Succinic Acid Derivatives in Experimental Studies." Neuroscience and Behavioral Physiology 46, no. 6 (2016): 677–81. http://dx.doi.org/10.1007/s11055-016-0296-8.

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22

Yakunin, Ya Yu, V. D. Dyachenko, and V. P. Litvinov. "ChemInform Abstract: Synthesis of 3-Cyano-5-ethoxycarbonyl-6-hydroxypyridine-2-thiol Derivatives." ChemInform 30, no. 34 (2010): no. http://dx.doi.org/10.1002/chin.199934167.

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23

Shcheblykina, Olesya V., Dmitry V. Shcheblykin, Konstantin S. Trunov, Anton P. Danilenko, and Vladimir S. Lipatov. "Experimental study of new derivatives of 3-hydroxypyridine as pharmacological agents for the correction of ischemic brain injury after intracerebral hemorrhage." Research Results in Pharmacology 8, no. 1 (2022): 71–83. http://dx.doi.org/10.3897/rrpharmacology.8.80378.

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Introduction: Limiting the action of secondary injury factors can improve the prognosis in acute cerebral accidents. The aim of the investigation is to study the neuroprotective effects of 3-hydroxypyridine derivatives. Materials and methods: The study was performed in Wistar rats. An intracerebral hemorrhage (ICH) model was used. The animals were once administered intraperitoneally with the test drugs 1 hour before the surgery and on the 1st, 2nd and 3rd days. The registration of behaviors and condition of the animals on days 1, 3, 7 and 14 and the morphological examination of the brain were

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24

Kolesnichenko, P. D., O. V. Scheblykina, N. I. Nesterova, et al. "ADDITIVE NEUROPROTECTIVE EFFECT OF 3-HYDROXYPYRIDINE DERIVATIVES AND HUMAN ERYTHROPOETIN ANALOGUE ON A HEMORRHAGIC STROKE MODEL IN RATS." Pharmacy & Pharmacology 8, no. 3 (2020): 169–80. http://dx.doi.org/10.19163/2307-9266-2020-8-3-169-180.

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The correction of free radical oxidation processes is one of the most promising strategies of neuroprotection in acute cerebrovascular disorders.The aim of the study is an experimental study of the neuroprotective effects of 3-hydroxypyridine and erythropoietin derivatives, as well as their combined use.Materials and methods. The study was performed on 109 male Wistar rats. The neuroprotective effect of the substances was studied on a hemorrhagic stroke model. The study drugs were administered to the animals intraperitoneally. Carbamylated darbepoetin was administered three times in advance at

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25

Ilkimen, Halil. "Synthesis and characterization of mixed ligand Cu(II) complexes of 2-methoxy-5-sulfamoylbenzoic acid and 2-aminopyridine derivatives." Macedonian Journal of Chemistry and Chemical Engineering 38, no. 1 (2019): 13. http://dx.doi.org/10.20450/mjcce.2019.1698.

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A novel Cu(II) complex 1 of 2-methoxy-5-sulfamoylbenzoic acid (Hsba) and eight novel mixed-ligand Cu(II) complexes 2–9 have been prepared using Hsba and 2-aminopyridine derivatives [2,3-diaminopyridine (2,3dap), 2,3-diamino-5-bromopyridine (2,3da5Brp), 2,3-diamino-5-chloropyridine (2,3da5Clp), 2-amino-3-benzyloxypyridine (2a3bxp), 2-amino-3-hydroxypyridine (2a3OHp), 2-amino-3-methylpiridine (2a3mp), 2-amino-3-methyl-6-ethylpiridine (2a3m6Etp) and 2-amino-3-nitro-6-methylpiridine (2a3NO26mp)], respectively. The structures of the amorphous metal complexes have been proposed by evaluating the dat

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26

Smirnova, Kseniya, and Dmitriy Gildikov. "Comparative efficacy of antioxidant drugs in an in vitro experiment." Russian veterinary journal 2021, no. 2 (2021): 37–40. http://dx.doi.org/10.32416/2500-4379-2021-2-37-40.

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The aim of this work was to study the antioxidant activity of 3-hydroxypyridine derivatives: Mexidol-Vet® and Emycidin in a model oxidation system. Using the chemiluminescence method, it was found that the introduction of Mexidol-Vet® into the test system at a dose of 1 mg reliably suppresses the amplitude of a fast flash and decreases the formation of photons (light sum value), compared with the test system / placebo and the test system / Emicidin. The antioxidant activity of Mexidol-Vet® is significantly higher than Emicidin by 28.1%.

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27

Volchegorskii, I. A., I. Yu Miroshnichenko, L. M. Rassokhina, R. M. Faizullin, K. E. Pryakhina, and A. V. Kalugina. "Anxiolytic and Antidepressant Actions of 3-Hydroxypyridine and Succinic Acid Derivatives in Alloxan Diabetes." Neuroscience and Behavioral Physiology 46, no. 6 (2016): 620–25. http://dx.doi.org/10.1007/s11055-016-0287-9.

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28

García Liñares, Guadalupe, Gonzalo Parraud, Carlos Labriola, and Alicia Baldessari. "Chemoenzymatic synthesis and biological evaluation of 2- and 3-hydroxypyridine derivatives against Leishmania mexicana." Bioorganic & Medicinal Chemistry 20, no. 15 (2012): 4614–24. http://dx.doi.org/10.1016/j.bmc.2012.06.028.

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29

Volchegorskii, I. A., A. I. Sinitskii, I. Yu Miroshnichenko, and L. M. Rassokhina. "Effects of 3-Hydroxypyridine and Succinic Acid Derivatives on Monoamine Oxidase Activity In Vitro." Pharmaceutical Chemistry Journal 52, no. 1 (2018): 26–29. http://dx.doi.org/10.1007/s11094-018-1760-2.

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30

Skachilova, Sophiya Ya., Vera Ragulina, Darya Kostina та Youri Burda. "TEST SYSTEM FOR EVALUATION OF THE INFLUENCE OF THE BIOLOGICAL ACTIVITY OF SUBSTANCES ON THE SIGNAL SYSTEM OF NF-κB: FOCUS ON THE DERIVATIVES OF 3-HYDROXYPYRIDINE". Research Results in Pharmacology 3, № (2) (2017): 50–56. https://doi.org/10.18413/2313-8971-2017-3-2-50-56.

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Introduction: The nuclear factor kappa B is one of the most promising targets for the development of innovative medicines in the development of modern pharmacology and the formation of the concept of targeted therapy. Potential candidates modulating the activity of this transcription factor are 3-hydroxypyridine derivatives. Materials and methods: At the first stage of our study, 11 pharmacological agents-inhibitors of NF-κB in vitro were screened with an estimate of the activity of the p65 subunit in mononuclear cells stimulated by bacterial lipopolysaccharide. The most active substances were

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31

Volchegorskii, I. A., I. Yu Miroshnichenko, and L. M. Rassokhina. "Acute Antidepressant Effects of Derivatives of 3-Hydroxypyridine and Succinic Acid in Experiments on Rats." Neuroscience and Behavioral Physiology 49, no. 4 (2019): 495–501. http://dx.doi.org/10.1007/s11055-019-00761-9.

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32

Sabet, Razieh, and Afshin Fassihi. "QSAR Study of Antimicrobial 3-Hydroxypyridine-4-one and 3-Hydroxypyran-4-one Derivatives Using Different Chemometric Tools." International Journal of Molecular Sciences 9, no. 12 (2008): 2407–23. http://dx.doi.org/10.3390/ijms9122407.

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33

Fassihi, Afshin, Daryoush Abedi, Lotfollah Saghaie, et al. "Synthesis, antimicrobial evaluation and QSAR study of some 3-hydroxypyridine-4-one and 3-hydroxypyran-4-one derivatives." European Journal of Medicinal Chemistry 44, no. 5 (2009): 2145–57. http://dx.doi.org/10.1016/j.ejmech.2008.10.022.

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34

Lutsenko, R. V. "EFFECT OF 2-HYDROXY-N-NAPHTHALENE-1-YL-2-(2-OXO-1,2-DIHYDRO-INDOLE-3-YLYDENE)-ACETAMIDE ON KIDNEY FUNCTION IN EXPERIMENTAL RENAL FAILURE." Актуальні проблеми сучасної медицини: Вісник Української медичної стоматологічної академії 23, no. 1 (2023): 94–97. http://dx.doi.org/10.31718/2077-1096.23.1.94.

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Heterocyclic compounds are the basis for a significant number of medicinal substances. Among them, there is indole and derivatives of 2-oxoindolin-3-glyoxylic acid. This group of compounds has been found out to have neurotropic effects as well as cardio- and hepatoprotective properties. This preceded the study of their nephroprotective activity in the experimental pathology. The aim of the work is to study the effect of 2-hydroxy-N-naphthalen-1-yl-2(2-oxo-1,2-dihydro-indol-3-ylidene)-acetamide on the excretory function of kidneys in the experimental acute renal failure. Materials and met

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35

Volchegorskii, I. A., I. Yu Miroshnichenko, L. M. Rassokhina, R. M. Faizullin, and K. E. Pryakhina. "Effects of Derivatives of 3-Hydroxypyridine and Succinic Acid on Stereotypical Behavior and Catalepsy in Mice." Neuroscience and Behavioral Physiology 48, no. 8 (2018): 947–53. http://dx.doi.org/10.1007/s11055-018-0654-9.

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36

Volchegorskii, I. A., L. M. Rassokhina, and I. U. Miroshnichenko. "Dopaminergic potential of domestic 3-hydroxypyridine and succinic acid derivatives and prospects for their therapeutic «retargeting»." Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova 123, no. 8 (2023): 21. http://dx.doi.org/10.17116/jnevro202312308121.

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37

Volchegorskii, I. A., L. M. Rassokhina, and I. U. Miroshnichenko. "Possibilities of «therapeutic retargeting» of 3-hydroxypyridine and succinic acid derivatives due to their dopaminergic action." Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova 124, no. 3 (2024): 17. http://dx.doi.org/10.17116/jnevro202412403117.

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38

Yasnetsov, V. V., S. K. Karsanova, and Vik V. Yasnetsov. "STUDIES OF THE NEUROPROTECTIVE AND ANTI-AMNESTIC EFFECTIVENESS OF THE COMBINATION OF MELATONIN WITH 3-HYDROXYPYRIDINE DERIVATIVES." Aerospace and Environmental Medicine 51, no. 2 (2017): 30–34. http://dx.doi.org/10.21687/0233-528x-2017-51-2-30-34.

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39

Kiruba, G. S. M., and Ming Wah Wong. "Tautomeric Equilibria of Pyridoxal-5‘-phosphate (Vitamin B6) and 3-Hydroxypyridine Derivatives: A Theoretical Study of Solvation Effects." Journal of Organic Chemistry 68, no. 7 (2003): 2874–81. http://dx.doi.org/10.1021/jo0266792.

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40

Kolesnichenko, Pavel D., Ekaterina G. Pokhvoshcheva, Ekaterina S. Chakina, Konstantin M. Reznikov, Irina A. Popova, and Irina N. Dolzhikova. "Cardioprotective Effectiveness of a Combination of 2-Ethyl-6-Methyl-3-Hydroxypyridine Enantiomers and Rosuvastatin in a Model of Doxorubicin Cardiomyopathy." Kuban Scientific Medical Bulletin 26, no. 6 (2019): 93–106. http://dx.doi.org/10.25207/1608-6228-2019-26-6-93-106.

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Aim. To study the cardioprotective effect of levorotatory ethylmethylhydroxypyridine malate enantiomer in combination with rosuvastatin on the model of doxorubicin cardiomyopathy.Material and methods. The research was conducted using 80 Langendorff perfused Wistar rat hearts (OOO “Kardioprotekt”, Saint-Petersburg) after a 3-day simulation of doxorubicin cardiomyopathy. The selection criteria for the evaluation of cardioprotective effect in the administration of ethylmethylhydroxypyridine derivatives and their combination with rosuvastatin were the indicators of left ventricular contractility,

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41

Volchegorskii, I. A., I. Yu Miroshnichenko, and L. M. Rassokhina. "Effects of 3-hydroxypyridine and Succinic Acid Derivatives on Resistance to Acute Adrenaline Intoxication and Formalin Edema in Mice." Pharmaceutical Chemistry Journal 48, no. 9 (2014): 565–68. http://dx.doi.org/10.1007/s11094-014-1152-1.

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42

FALYAKHOV, I. F., R. Z. GILMANOV, G. P. SHARNIN, and T. G. BOLSHAKOVA. "ChemInform Abstract: Reactivity of Heterocyclic Compounds at Nitration. Part 8. Study of Nitration of 3-Hydroxypyridine and Its Derivatives." ChemInform 30, no. 2 (2010): no. http://dx.doi.org/10.1002/chin.199902040.

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43

Trunov, Konstantin S. "Method for obtaining supramolecular complex based on 3-ohypyridine derivatives and its application for correction of osteoporosis." Research Results in Pharmacology 9, no. 3 (2023): 21–25. http://dx.doi.org/10.18413/rrpharmacology.9.10039.

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Introduction: Currently, there are no safe and ideal medicines for the prevention and treatment of oophorectomy-induced osteoporosis. The development of an effective pharmacotherapy for hypoestrogen-induced osteoporosis is an important task of pharmacology. Materials and Methods: A new supramolecular complex (composition №1) was obtained on the basis of 3-hydroxypyridine derivatives: 2-ethyl-6-methyl-3-hydroxypyridinium 3-pyridinocarbonoate and 2-ethyl-6-methyl-3-hydroxypyridinium N-acetyl-6-aminohexanoate in a ratio of 1:3 by topochemical synthesis. The study of the osteoprotective activity o

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Yasnetsov, Vik V., Yu V. Ivanov, S. К. Karsanova, and V. V. Yasnetsov. "EFFECT OF MELATONIN COMBINED WITH 3-HYDROXYPYRIDINE DERIVATIVES ON NEURONS OF THE LATERAL VESTIBULAR NUCLEUS AND CEREBELLUM CORTEX IN ANIMALS." Aerospace and Environmental Medicine 54, no. 1 (2020): 69–74. http://dx.doi.org/10.21687/0233-528x-2020-54-1-69-74.

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Yasnetsov, Vik V., Yu V. Ivanov, S. К. Karsanova, and V. V. Yasnetsov. "EFFECT OF MELATONIN COMBINED WITH 3-HYDROXYPYRIDINE DERIVATIVES ON NEURONS OF THE PARIETAL ASSOCIATION CORTEX IN THE BRAIN OF ANIMALS." Aerospace and Environmental Medicine 54, no. 2 (2020): 84–88. http://dx.doi.org/10.21687/0233-528x-2020-54-2-84-88.

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Volchegorskii, I. A., A. I. Sinitskii, I. Yu Miroshnichenko, and L. M. Rassokhina. "The Effect of 3-Hydroxypyridine and Succinic Acid Derivatives on Hippocampal Monoamine Oxidase Activity in Rats with Alloxan-Induced Diabetes." Journal of Evolutionary Biochemistry and Physiology 56, no. 1 (2020): 11–21. http://dx.doi.org/10.1134/s0022093020010020.

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Yasnetsov, Vik V., Yu V. Ivanov, S. К. Karsanova, and V. V. Yasnetsov. "ACTION OF MELATONIN COMBINATIONS WITH 3-HYDROXYPYRIDINE DERIVATIVES ON NEURONS OF THE 1ST VESTIBULAR ZONE OF THE CEREBRAL CORTEX IN MAMMALS." Aerospace and Environmental Medicine 55, no. 3 (2021): 81–86. http://dx.doi.org/10.21687/0233-528x-2021-55-3-81-86.

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Experiments with cats showed that new 3-hydroxypyridine derivative IBKhF-27, mexidol and melatonin, and combination of IBKhF-27 with melatonin and mexidol affected directly 84.8; 67.8; 77.4; 97.9 and 88.1 % neurons of the 1st vestibular zone of the cerebral cortex, respectively. Inhibition by IBKhF-27 was observed 1.4 times more often than by mexidol. Combinations of IBKhF-27 with melatonin and mexidol produced the inhibitive effects on neurons oftener than each component separately; the direct effect of IBKhF-27 with melatonin occurred oftener than each of these two components separately. Als

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Agarkova, A. A., M. V. Pokrovsky, P. D. Kolesnichenko, and A. V. Nesterov. "The effect of new derivatives of 3-hydroxypyridine on the development of brain edema in bacterial purulent meningitis in experimental conditions." Сибирский научный медицинский журнал 41, no. 3 (2021): 32–37. http://dx.doi.org/10.18699/ssmj20210304.

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Bacterial purulent meningitis (BPM) is one of the most severe infectious and inflammatory diseases of the nervous system, which is characterized by high mortality and frequent development of residual neurological deficits. Edema and swelling of the brain is the most common cause of death in patients with neuroinfections. Most often, brain edema develops in pneumococcal meningitis (PM), which has the highest mortality rate among all bacterial meningitis. The aim of our work was to study the effect of new derivatives of 3-hydroxypyridine, 2-ethyl-6-methyl-3-hydroxypyridinium 2.6-dichlorophenyl (

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Upanan, Supranee, Kanjana Pangjit, Chairat Uthaipibull, Suthat Fucharoen, Andrew T. McKie та Somdet Srichairatanakool. "Combined treatment of 3-hydroxypyridine-4-one derivatives and green tea extract to induce hepcidin expression in iron-overloaded β-thalassemic mice". Asian Pacific Journal of Tropical Biomedicine 5, № 12 (2015): 1010–17. http://dx.doi.org/10.1016/j.apjtb.2015.09.007.

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Sadeghian, Sara, Fateme Zare, Mehdi Khoshneviszadeh, et al. "Synthesis, biological evaluation, molecular docking, MD simulation and DFT analysis of new 3-hydroxypyridine-4-one derivatives as anti-tyrosinase and antioxidant agents." Heliyon 10, no. 15 (2024): e35281. http://dx.doi.org/10.1016/j.heliyon.2024.e35281.

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