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Journal articles on the topic '3-methoxyflavone'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

Budzianowski, Jaromir, and Eckhard Wollenweber. "Rare Flavones from the Glandular Leaf Exudate of the Oxlip, Primula Elatior L." Natural Product Communications 2, no. 3 (2007): 1934578X0700200. http://dx.doi.org/10.1177/1934578x0700200308.

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5,6,2′,3′,6′-Pentamethoxyflavone (1), together with 3′,5′-dihydroxy-4′-methoxyflavone (2), 2′-methoxyflavone, 3′-methoxyflavone, 3′,4′-dimethoxyflavone, 2′,5′-methoxyflavone, 3′-hydroxy-4′,5′-dimethoxyflavone, 3′,4′,5′-trimethoxyflavone, and 3′-hydroxy-4′,5′-methylenedioxyflavone were found in the leaf exudate of the oxlip, Primula elatior (Primulaceae). The structures of flavones 1 and 2 were substantiated by 2D NMR spectroscopy.

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2

Legoale, Percival B., Mahlori J. Mashimbye, and Teunis van Ree. "Antiinflammatory and Antioxidant Flavonoids from Helichrysum Kraussii and H. odoratissimum Flowers." Natural Product Communications 8, no. 10 (2013): 1934578X1300801. http://dx.doi.org/10.1177/1934578x1300801015.

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Organic extracts of the flowers of Helichrysum kraussii and H. odoratissimum contain several bioactive flavonoids, characterized by 1H NMR, 13C NMR and mass spectrometry. Four flavonoids, 5,6-dihydroxy-3,7,8-trimethoxyflavone, 5,7-dihydroxy-3-methoxyflavone, 3′,4′,5,7-tetrahydroxy-3-methoxyflavone and 3′,4′,3,5-tetrahydroxy-7-methoxyflavone, have antioxidant activity by the DPPH free radical assay, while 5,6-dihydroxy-3,7,8-trimethoxyflavone and 3′,4′,3,5-tetrahydroxy-7-methoxyflavone have promising anti-inflammatory activity.

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3

Ren, S. C., Q. Q. Qiao, and X. L. Ding. "Antioxidative activity of five flavones glycosides from corn silk (Stigma maydis)." Czech Journal of Food Sciences 31, No. 2 (2013): 148–55. http://dx.doi.org/10.17221/194/2012-cjfs.

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Five flavones glycosides (i.e., 2''-O-&alpha;-l-rhamnosyl-6-C-3''deoxyglucosyl-3'-methoxyluteolin, ax-5'-methane-3'-methoxymaysin, ax-4''-OH-3'-methoxymaysin, 6,4'-dihydroxy-3'-methoxyflavone-7-O-glucoside, and 7,4'-dihydroxy-3&rsquo;-methoxyflavone-2''-O-&alpha;-l-rhamnosyl-6-C-fucoside) were successfully isolated from corn silk and identified. We evaluated their antioxidant activity among in vitro assay systems. Most of the flavones glycosides showed a high antioxidant activity in a lecithin liposome system, as well as a strong scavenging activity against radicals such as 1,1-dip

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4

Parvez, M., and O. N. Ogbeide. "3-Hydroxy-4′-methoxyflavone from Millettia zechiana." Phytochemistry 29, no. 6 (1990): 2043–44. http://dx.doi.org/10.1016/0031-9422(90)85069-r.

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5

Huo, Chen, Sullim Lee, Min Jeong Yoo, et al. "Methoxyflavones from Black Ginger (Kaempferia parviflora Wall. ex Baker) and their Inhibitory Effect on Melanogenesis in B16F10 Mouse Melanoma Cells." Plants 12, no. 5 (2023): 1183. http://dx.doi.org/10.3390/plants12051183.

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Kaempferia parviflora Wall. ex Baker (Zingiberaceae), commonly known as Thai ginseng or black ginger, is a tropical medicinal plant in many regions. It has been traditionally used to treat various ailments, including ulcers, dysentery, gout, allergies, abscesses, and osteoarthritis. As part of our ongoing phytochemical study aimed at discovering bioactive natural products, we investigated potential bioactive methoxyflavones from K. parviflora rhizomes. Phytochemical analysis aided by liquid chromatography–mass spectrometry (LC-MS) led to the isolation of six methoxyflavones (1–6) from the n-he

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6

Cornard, J. P., L. Vrielynck, J. C. Merlin, and J. C. Wallet. "Structural and vibrational study of 3-hydroxyflavone and 3-methoxyflavone." Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 51, no. 5 (1995): 913–23. http://dx.doi.org/10.1016/0584-8539(94)01425-g.

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7

Shoja, M., and P. Sullivan. "Crystal structure of 3-hydroxy-2'-methoxyflavone, C16H12O4." Zeitschrift für Kristallographie - New Crystal Structures 214, no. 2 (1999): 237–38. http://dx.doi.org/10.1515/ncrs-1999-0244.

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8

Mahboobi, Siavosh, and Herwig Pongratz. "Synthesis Of 2'-Amino-3'-Methoxyflavone (Pd 98059)." Synthetic Communications 29, no. 10 (1999): 1645–52. http://dx.doi.org/10.1080/00397919908086149.

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9

Shoja, M., P. Sullivan, D. Athanasopoulos, and R. Kabbani. "Crystal structure of 3-hydroxy-7-methoxyflavone, C16H12O4." Zeitschrift für Kristallographie - New Crystal Structures 213, no. 1-4 (1998): 607–8. http://dx.doi.org/10.1524/ncrs.1998.213.14.607.

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10

Shoja, M. "Crystal structure of 3-hydroxy-6-methoxyflavone, C16H12O4." Zeitschrift für Kristallographie - New Crystal Structures 213, no. 1-4 (1998): 771–72. http://dx.doi.org/10.1524/ncrs.1998.213.14.771.

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11

Meng, Zhi Fen, Xue Feng Guo, Yong Zhu, and Shu Ke Jing. "Analysis of Antioxidant Properties and Major Components of the Extract of Paulownia tomentosa Steud Flowers." Advanced Materials Research 1010-1012 (August 2014): 164–77. http://dx.doi.org/10.4028/www.scientific.net/amr.1010-1012.164.

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PaulowniatomentosaSteud flowers have been used for many therapeutic purposes in traditional pharmacopeia. The components of the extract ofPaulowniatomentosaSteud flowers were separated using ethanol elution. The antioxidant properties of different components (20% component, 40% component, 60% component, and 80% component) and synthetic antioxidants (BHA and BHT) were evaluated by scavenging DPPH, superoxide anions, and hydroxyl radical methods. All components showed strong antioxidant properties, especially the 60% component, which exhibited excellent antioxidant activity. These components may

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12

Saoudi, Mohamed Marouane, Jalloul Bouajila, Rami Rahmani, and Khaled Alouani. "Phytochemical Composition, Antioxidant, Antiacetylcholinesterase, and Cytotoxic Activities of Rumex crispus L." International Journal of Analytical Chemistry 2021 (July 2, 2021): 1–16. http://dx.doi.org/10.1155/2021/6675436.

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Rumex crispus L. (R. crispus) is regarded as an aromatic plant. It was used for its excellent biological properties in traditional medicine. The aerial part was extracted successively by maceration with three solvents increasing polarity (cyclohexane (CYH), dichloromethane (DCM), and methanol (MeOH)) to evaluate their chemical compositions and biological activities. The extracts were rich in phenolic compounds (13.0 to 249.8 mg GAE/g of dry weight (dw)). The MeOH extract has presented remarkable IC50 = 6.2 μg/mL for anti-DPPH and 31.6 μg/mL for anti-AChE. However, the DCM extract has the highe

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13

Reddy, Nimmanapalli P., Bandi A. K. Reddy, Duvvuru Gunasekar, Alain Blond, Bernard Bodo, and Reddy V. Raju. "A Novel Acylated Flavone Glycoside from Andrographis nallamalayana." Natural Product Communications 2, no. 5 (2007): 1934578X0700200. http://dx.doi.org/10.1177/1934578x0700200512.

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A new acylated flavone glycoside, skullcapflavone I 2′- O-β-D-(6″- E-cinnamoyl) glucopyranoside (1), together with two known flavones, 5,2′-dihydroxy-7-methoxyflavone (2) and 5,2′,6′-trihydroxy-7-methoxyflavone-2′- O-β-D-glucopyranoside (3), and two known labdane diterpenoids, 14-deoxy-11,12-didehydroandrographolide (4) and andrographolide (5) were isolated from the whole plant of Andrographis nallamalayana. Structural elucidation of the new compound, as well as of the known compounds was achieved by various NMR techniques including 1H-1H COSY, HSQC, HMBC and ROESY experiments, ESITOF mass spe

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14

Nikolova, Milena, Elina Yankova-Tsvetkova, Tatyana Stefanova, and Strahil Berkov. "Exudate Flavonoids of Primula veris Leaves and Their Inhibitory Activity on Lolium perrene Seed Germination." Proceedings of the Bulgarian Academy of Sciences 76, no. 3 (2023): 388–93. http://dx.doi.org/10.7546/crabs.2023.03.07.

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In the present study exudate flavonoids from P. veris leaves were identified and their potential as inhibitors on L. perrene seed germination was evaluated. Leaves of P. veris were collected from natural population. Leaf exudate was obtained by dipping whole leaves into acetone for 2--3 min. Chemical composition of the exudate was analysed by GC/MS. The seed germination test was done in Petri dishes. Flavonoid aglycones were found as main components of the exudate (over 50% of all compounds). Unsubstituted flavone, 2'-methoxyflavone, 3'-methoxyflavone, 3',4'-dimethoxyflavone, 2',5'-dimethoxyfl

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15

Mahboobi, Siavosh, and Herwig Pongratz. "ChemInform Abstract: Synthesis of 2′-Amino-3′-methoxyflavone (PD 98059)." ChemInform 30, no. 31 (2010): no. http://dx.doi.org/10.1002/chin.199931169.

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16

Shimada, Tsutomu, Haruna Nagayoshi, Norie Murayama, et al. "Oxidation of 3’-methoxyflavone, 4’-methoxyflavone, and 3’,4’-dimethoxyflavone and their derivatives having 5,7-dihydroxyl moieties by human cytochromes P450 1B1 and 2A13." Xenobiotica 52, no. 2 (2022): 134–45. http://dx.doi.org/10.1080/00498254.2022.2062486.

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17

N, SULOCHANA, and NAGARAJAN PRAVATHI. "Electrochemical Reduction of 3-Hydroxy-4' -methoxyflavone on GCE in DMF Solution." Journal of Indian Chemical Society Vol. 70, Aug 1993 (1993): 725–26. https://doi.org/10.5281/zenodo.5928719.

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Department of Chemistry, Regiondl Engineering College, Tiruchirappalli 620 015 Department of Chemistry, Bishop Heber College, Tiruchirappalli 620 017 <em>Manuscript received 9 April 1992 , revised 30 October 1992, accepted 7 January 1993</em> Electrochemical Reduction of 3-Hydroxy-4' -methoxyflavone on GCE in DMF Solution

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18

Wallet, J. C., E. M. Gaydou, A. Fadlane, and A. Baldy. "Structure of 3-methoxy-2-phenyl-4H-1-benzopyran-4-one (3-methoxyflavone)." Acta Crystallographica Section C Crystal Structure Communications 44, no. 2 (1988): 357–59. http://dx.doi.org/10.1107/s0108270187010850.

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19

KOSTRZEWA-SUSŁOW, EDYTA, MONIKA DYMARSKA, and TOMASZ JANECZKO. "Microbial Transformations of 3-methoxyflavone by the Strains of Aspergillus niger." Polish Journal of Microbiology 63, no. 1 (2014): 111–14. http://dx.doi.org/10.33073/pjm-2014-016.

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Microbial transformation of 3-methoxyflavone into 3'-hydroxyflavon-3-yloxymethyl myristate was presented. Six filamentous fungi were used as biocatalysts: a wild strain of Aspergillus niger KB, its four UV mutants (A. niger MB, SBP, SBJ, 13/5) and the strain of Penicillium chermesinum 113. The highest yields were observed for the strains of A. niger KB and A. niger SBP (69.8% and 63.1%, respectively).

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20

Wallet, J. C., E. M. Gaydou, B. Tinant, J. P. Declercq, and A. Baldy. "Structures of Two Planar Flavones: 4′-Methoxyflavone and 3′,4′-Dimethoxyflavone." Bulletin des Sociétés Chimiques Belges 100, no. 4 (2010): 339–43. http://dx.doi.org/10.1002/bscb.19911000407.

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21

Marquina, Silvia, Yolanda García, Laura Alvarez, and Jaime Tortoriello. "3-Acetoxy-7-methoxyflavone, a Novel Flavonoid from the Anxiolytic Extract of Salvia elegans (Lamiaceae)." Natural Product Communications 3, no. 2 (2008): 1934578X0800300. http://dx.doi.org/10.1177/1934578x0800300215.

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Oleanolic, ursolic and 3β, 23-dihydroxyolean-12-en-28-oic acids, together with the new flavonoid, 3-acetoxy-7-methoxyflavone (1), were isolated from the 60% aqueous ethanolic extract of the leaves and flowers of Salvia elegans with anxiolytic activity. The structure of 1 was established by combined spectral and chemical methods.

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22

Hussain, Nazim, Bibhuti Bhushan Kakoti, Mithun Rudrapal, et al. "Bioactive Antidiabetic Flavonoids from the Stem Bark of Cordia dichotoma Forst.: Identification, Docking and ADMET Studies." Molbank 2021, no. 2 (2021): M1234. http://dx.doi.org/10.3390/m1234.

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Cordia dichotoma Forst. (F. Boraginaceae) has been traditionally used for the management of a variety of human ailments. In our earlier work, the antidiabetic activity of methanolic bark extract of C. dichotoma (MECD) has been reported. In this paper, two flavonoid molecules were isolated (by column chromatography) and identified (by IR, NMR and mass spectroscopy/spectrometry) from the MECD with an aim to investigate their antidiabetic effectiveness. Molecular docking and ADMET studies were carried out using AutoDock Vina software and Swiss ADME online tool, respectively. The isolated flavonoi

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23

Lin, Fang-Ju, Feng-Lin Yen, Pei-Chun Chen, et al. "HPLC-Fingerprints and Antioxidant Constituents ofPhyla nodiflora." Scientific World Journal 2014 (2014): 1–8. http://dx.doi.org/10.1155/2014/528653.

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Phyla nodiflorais a creeping perennial herb, widely distributed in the most tropical and subtropical regions. It has been used as a folk medicine, herbal beverage, or folk cosmetic. For these usages, the development of a chemical quality control method of this plant is necessary. In the present study, ten compounds, namely, 3,7,4′,5′-tetrahydroxy-3′-methoxyflavone (1), nodifloretin (2), 4′-hydroxywogonin (3), onopordin (4), cirsiliol (5), 5,7,8,4′-tetrahydroxy-3′-methoxyflavone (6), eupafolin (7), hispidulin (8), larycitrin (9), andβ-sitosterol were isolated from the methanolic extract of the

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24

Suraj, B. Kalidhar. "Determination of methoxy group in the C-ring of a flavone using 1 H NMR." Journal of Indian Chemical Society Vol. 88, Jun 2011 (2011): 889–91. https://doi.org/10.5281/zenodo.5771368.

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IITT College of Engineering, Kala Amb, Sirmour-173 030, Himachal Pradesh, India <em>E-mail</em> : sbkalidhar@gmail.com <em>Manuscript received 21 May 2010. accepted 16 November 2010</em> When <sup>1</sup>H NMR of a 3-methoxyflavone is compared with its 3-demethoxyflavone, H-2' and H-6' are found to be downfield in the former. This general observation is helpful for structural studies In naturally occurring flavones. The two flavones under comparison must have the same substituents in the B-rings; and different substituents in the A-rings do not change this observed trend.

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25

Dymarska, Monika, Tomasz Janeczko, and Edyta Kostrzewa-Susłow. "Glycosylation of 3-Hydroxyflavone, 3-Methoxyflavone, Quercetin and Baicalein in Fungal Cultures of the Genus Isaria." Molecules 23, no. 10 (2018): 2477. http://dx.doi.org/10.3390/molecules23102477.

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Flavonoids are plant secondary metabolites with a broad spectrum of biological activities. In nature, they occur mainly in the form of glycosides, but their extraction is often difficult and expensive, as is chemical synthesis. We have shown that biotransformations are an excellent method for obtaining flavonoid glycosides. We are the first team to describe the use of Isaria microorganisms in biotransformations of flavonoid compounds. In the present study as biocatalysts, we used one strain of Isaria fumosorosea KCH J2 isolated from a spider carcass in green areas of Wroclaw and two strains of

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26

Strawa, Jakub W., Katarzyna Jakimiuk, Łukasz Szoka, et al. "New Polymethoxyflavones from Hottonia palustris Evoke DNA Biosynthesis-Inhibitory Activity in An Oral Squamous Carcinoma (SCC-25) Cell Line." Molecules 27, no. 14 (2022): 4415. http://dx.doi.org/10.3390/molecules27144415.

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Four new compounds, 5-hydroxy-2′,6′-dimethoxyflavone (4), 5-hydroxy-2′,3′,6′-trimethoxyflavone (5), 5-dihydroxy-6-methoxyflavone (6), and 5,6′-dihydroxy-2′,3′-dimethoxyflavone (7), and three known compounds, 1,3-diphenylpropane-1,3-dione (1), 5-hydroxyflavone (2), and 5-hydroxy-2′-methoxyflavone (3), were isolated from the aerial parts of Hottonia palustris. Their chemical structures were determined through the use of spectral, spectroscopic and crystallographic methods. The quantitative analysis of the compounds (1–7) and the zapotin (ZAP) in methanol (HP1), petroleum (HP6), and two chlorofor

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27

Trendafilova, Antoaneta, Desislava Raykova, Viktoria Ivanova, et al. "Phytochemical Characterization and Anti-Biofilm Activity of Primula veris L. Roots." Molecules 30, no. 8 (2025): 1702. https://doi.org/10.3390/molecules30081702.

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In this study, three new undescribed triterpene saponins named primulasaponin III–V (19–21) were isolated from the roots of Primula veris L. of Bulgarian origin together with the known primulasaponin I. Their structures were elucidated via 1D and 2D NMR spectroscopy and HR-ESI-MS. In addition, 17 known phenolic compounds (six flavones, three acetophenones, four bisbibenzyls, and four phenolic glycosides) were identified in the chloroform and methanol extracts. Among them, flavone, 2′-methoxyflavone, 3′-methoxyflavone, 3′-hydroxy-4′,5′-dimethoxyflavone, 2′,5′-dimethoxyflavone, 3′-methoxy-4′,5′-

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28

Hinterdobler, Wolfgang, Karin M. Valant-Vetschera, and Lothar Brecker. "New Primula-type Flavones from Exudates of Selected Dionysia spp. (Primulaceae)." Natural Product Communications 12, no. 11 (2017): 1934578X1701201. http://dx.doi.org/10.1177/1934578x1701201103.

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Hitherto unstudied Dionysia leucotricha and D. denticulata as well as new accessions of already studied species were analyzed for their exudate flavonoid profile. Results were compared with those of closely related species by HPLC-reinvestigation of existing exudate solutions. In addition to already known compounds typical of the Primula assemblage, three compounds were isolated from D. bryoides and identified as 2’-hydroxy-3’-methoxyflavone (1), 2’,3’-dimethoxyflavone (2) and 3’,5’-dimethoxyflavone (3), respectively, by HPLC and NMR. All compounds are new for the genus Dionysia, with compound

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29

Moldoch, Jaroslaw, Barbara Szajwaj, Milena Masullo, et al. "Phenolic Constituents of Knautia arvensis Aerial Parts." Natural Product Communications 6, no. 11 (2011): 1934578X1100601. http://dx.doi.org/10.1177/1934578x1100601117.

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A new C-6 flavone glycoside (6), together with seven known compounds, cryptochlorogenic acid (1), chlorogenic acid (2), 2- O- trans-caffeoylhydrocitric acid (3), isovitexin 7-β-D-glucopyranoside (4), 7,4′-dihydroxy-5-methoxyflavone-6- C-β-D-glucopyranoside (5), 3,5- O-dicaffeoylquinic acid (7) and 4,5- O-dicaffeoylquinic acid (8), were isolated from the aerial parts of Knautia arvensis. Their structures were elucidated by extensive spectroscopic methods including 1D- (1H, 13C and TOCSY) and 2D-NMR (DQF-COSY, HSQC, HMBC) experiments, as well as ESIMS analysis. Compounds 1, 3-5 and 8 are reporte

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30

Rajbhandari, M., and U. Lindequist. "Isolation of Flavonoids from Anaphalis Busua and their Antibacterial Activity." Journal of Institute of Science and Technology 25, no. 1 (2020): 1–6. http://dx.doi.org/10.3126/jist.v25i1.29415.

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Anaphalis busua (Buch-Ham ex D. Don) is traditionally used to treat cuts and wounds. In the agar dilution method, the hexane extract of the aerial part of A. busua exhibited potent antibacterial activity with a minimal inhibitory concentration of 25 μg/ml against Bacillus subtilis and 500 μg/ml against Staphylococcus aureus. For the isolation of antibacterial compounds, the hexane extract was fractionated by silica gel and Sephadex LH 20 column chromatography. The direct bioautography method was used to determine the antibacterial activity of the fractions. The active fractions were finally pu

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Syah, Yana M., Lia D. Juliawaty, Sjamsul A. Achmad, et al. "Phenolic Constituents from the Wood of Morus australis with Cytotoxic Activity." Zeitschrift für Naturforschung C 63, no. 1-2 (2008): 35–39. http://dx.doi.org/10.1515/znc-2008-1-207.

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A new methylated flavonol, 5,7,2 ′,4 ′-tetrahydroxy-3-methoxyflavone (1), had been isolated from the methanol extract of the wood of Morus australis, along with nine known compounds, kuwanon C (2), morusin (3), morachalcone A (4), oxyresveratrol (5), 4 ′-(2-methyl-2-buten- 4-yl)oxyresveratrol (6), moracins M (7) and C (8), alboctalol (9), and macrourin B (10). The structures of these compounds were determined based on spectral evidence, including UV, IR, NMR, and mass spectra. Cytotoxic properties of compounds 1 →10 were evaluated against murine leukemia P-388 cells. The prenylated stilbene 6

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Chung, Ha Sook. "Antiproliferative Activity of Allium monanthum in HT-29 Human Colorectal Adenocarcinoma Cells." Korean Tea Society 28, no. 3 (2022): 22–32. http://dx.doi.org/10.29225/jkts.2022.28.3.22.

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This study was designed to identify the phytochemicals of Allium monanthum with antiproliferative effect on HT-29 human colorectal adenocarcinoma cells through the activity-guided fractionation and isolation method. In particular, compounds 1-8 were isolated from A. monanthum, and determined to be apigenin (1), isorhamnetin (2), 5,7,3′,4′-tetrahydroxy-3-methoxyflavone (3), luteolin (4), myricetin (5), isorhamnetin-3-O-β-D-glucoside (6), isorhamnetin-3-O-β-D-rutinoside (7), and luteolin-7-O-β-D-glucoside (8) by comparing the 1D-, 2D-NMR, and ESI-MS spectral data. Of these, compound 5 significan

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33

Romero-Benavides, Juan Carlos, Gina C. Ortega-Torres, Javier Villacis, Sara L. Vivanco-Jaramillo, Karla I. Galarza-Urgilés, and Natalia Bailon-Moscoso. "Phytochemical Study and Evaluation of the Cytotoxic Properties of Methanolic Extract from Baccharis obtusifolia." International Journal of Medicinal Chemistry 2018 (August 1, 2018): 1–5. http://dx.doi.org/10.1155/2018/8908435.

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Some species of the Baccharis genus have been shown to possess important biomedical properties, including cytotoxic activity. In this study, we examined the cytotoxic effect of methanol extract from Baccharis obtusifolia (Asteraceae) in cancer cell lines of prostate (PC-3), colon (RKO), astrocytoma (D-384), and breast (MCF-7). The methanolic extract displayed the largest substantial cytotoxic effect in lines of colon cancer (RKO) and cerebral astrocytoma (D-384). Chromatographic purification of the B. obtusifolia methanolic extract led to the isolation and identification of 5,4′-dihydroxy-7-me

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34

Ahmad, N. A., N. H. Nordin, M. H. Nadri, R. M. Zulkifli, F. Ahmad, and H. M. Sirat. "Bioactivities and Cytotoxicities Effects of 3′,4′-Dihydroxy-7-Methoxyflavone and 2′-Hydroxy-3,4,3′,4′-Tetramethoxychalcone." Advanced Science Letters 19, no. 12 (2013): 3628–31. http://dx.doi.org/10.1166/asl.2013.5218.

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Chu, Hong-Biao, Ning-Hua Tan, and Yu-Mei Zhanga. "Chemical Constituents from Pedicularis rex C. B. Clarke." Zeitschrift für Naturforschung B 62, no. 11 (2007): 1465–70. http://dx.doi.org/10.1515/znb-2007-1117.

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One new ionone glycoside, pedicurexoside (1), one new flavonoid, 5, 4′-dihydroxy-3′-methoxyflavone- 7-O-6″-n-butyryl-β -D-glucopyranoside (2), two new iridoid glycosides, 6-O-ethyl-aucubin (7), 6-O-ethyl-epiaucubin (8), and one new phenylpropanoid glycoside, 4-hydroxy-phenylpropenyl- α-L-rhamnopyranosyl-(1→3)-4-O- feruloyl-β -D-glucopyranoside (13), together with eleven known compounds, apigenin (3), luteolin (4), chrysoeriol (5), luteolin-7-O-β -D-glucopyranoside (6), aucubin (9), yuheinoside (10), euphroside (11), mussaenoside (12), verbascoside (14), martynoside (15) and isomartynoside (16)

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Kaszás, László, Tarek Alshaal, Hassan El-Ramady, et al. "Identification of Bioactive Phytochemicals in Leaf Protein Concentrate of Jerusalem Artichoke (Helianthus tuberosus L.)." Plants 9, no. 7 (2020): 889. http://dx.doi.org/10.3390/plants9070889.

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Jerusalem artichoke (JA) is widely known to have inulin-rich tubers. However, its fresh aerial biomass produces significant levels of leaf protein and economic bioactive phytochemicals. We have characterized leaf protein concentrate (JAPC) isolated from green biomass of three Jerusalem artichoke clones, Alba, Fuseau, and Kalevala, and its nutritional value for the human diet or animal feeding. The JAPC yield varied from 28.6 to 31.2 g DM kg−1 green biomass with an average total protein content of 33.3% on a dry mass basis. The qualitative analysis of the phytochemical composition of JAPC was p

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Zaharaddeen, Abdullahi, Magaji Yakubu, Anthony Vantsawa Philip, Muhammad Sheshe Sadeeq, and Abdullahi Alhaji Jibril. "Anti-Diabetic Potential of Gymnema Sylvestre: In Vitro and in Silico Analysis." International Journal of Pharmaceutical and Bio-Medical Science 02, no. 08 (2022): 233–48. https://doi.org/10.5281/zenodo.6961967.

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Gymnema sylvestre (GS) is a powerful antidiabetic plant that has been utilized in ayurvedic, folk and homeopathic medicine for centuries. In this research, we evaluated the antidiabetic potential of methanolic leaf extract of Gymnema sylvestre. Fractionation was carried out using column chromatography and a total of twenty-eight (28) sub-fractions were obtained which were further screened and pooled into three (3) fractions (A, B and C) by thin layer chromatography based on their retention factor (Rf) values. The fractions were subjected to in vitro α-amylase and α-glucosidase inhi

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R., N. Yadava, and Jain Parol. "New biologically active flavonol glycoside from Cassia sophera Linn." Journal of Indian Chemical Society Vol. 84, Jul 2007 (2007): 683–87. https://doi.org/10.5281/zenodo.5824348.

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Natural Products Laboratory, Department of Chemistry, Dr. H. S. Gour University, Sagar-470 003, Madhya Pradesh, India <em>Manuscript received 12 October 2006, accepted 4 May 2007</em> A new biologically active flavonol glycoside 1, m.p. 282-284 <sup>o</sup>c, m.f. C<sub>33</sub>H<sub>40</sub>O<sub>19</sub>, [M]<sup>+</sup> 740 (FABMS), has been isolated from ethanolic extract of the leaves of <em>Cassia sophera</em> Linn. along with a known compound 2, 8-prenyl- 3, 7 ,4' -trihydroxy-5-methoxyflavone. Compound I was characterized as 3, 7 ,4' -trihydroxy-7-mcthoxyflavone-5-<em>0</em

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Kurkin, Vladimir Aleksandrovich, Anna Evgen'evna Saveleva, and Anna Vladimirovna Kurkina. "DEVELOPMENT OF METHODS OF STANDARDIZATION OF FLOWERS OF SPREADING MARIGOLD (TAGETES PATULA L.)." chemistry of plant raw material, no. 4 (December 15, 2022): 219–29. http://dx.doi.org/10.14258/jcprm.2022049243.

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The spreading marigold (Tagetes patula L.), the family Aster (Asteraceae), or Composite (Compositae), is a prospective source of flavonoids. The aim of the study is to develop methods of standardization of marigold flowers rejected, consisting in determining the identity of this raw material and the quantitative determination of biologically active compounds. As a result of a comparative chromatographic study, the presence of flavonoids was detected upon detection at a wavelength of 254 and 366 nm and before and after reaction with an alcohol solution of aluminum chloride. The presence of patu

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Wang, Xinhui, Dujuan Wang, Xue Wang, et al. "Isoflavones from Camphorosma lessingii Inhibit the Organic Anion Transporters OAT1 and OAT3." Planta Medica 85, no. 03 (2018): 225–30. http://dx.doi.org/10.1055/a-0740-3255.

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AbstractPhytochemical investigation of Camphorosma lessingii has resulted in the isolation of four previously unreported isoflavones (1–4) and eight known compounds (5–12). Nine of these compounds (1–6, 8–10) are reported for the first time from members of the family Amaranthaceae. The structures of all isolated compounds were determined by spectroscopic methods, primarily one-dimensional and two-dimensional nuclear magnetic resonance and mass spectrometry. The absolute configuration of 6 was confirmed by circular dichroism. Inhibition of the organic anion transporters, OAT1 and OAT3, by the i

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Jakimiuk, Katarzyna, Jakub W. Strawa, Sebastian Granica, and Michał Tomczyk. "New Flavone C-Glycosides from Scleranthus perennis and Their Anti-Collagenase Activity." Molecules 26, no. 18 (2021): 5631. http://dx.doi.org/10.3390/molecules26185631.

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Three new flavone glycosides, one known flavone glycoside, and the phenolic derivative apiopaenonside were isolated and identified from the ethyl acetate fraction of the aerial parts of Scleranthus perennis. The planar structures were elucidated through extensive analysis of UV-Vis, IR, and 1H NMR and 13C NMR spectral data, including the 2D techniques COSY, HSQC, and HMBC, as well as ESI mass spectrometry. The isolated compounds were established as 5,7,3′-trihydroxy-4′-acetoxyflavone-8-C-β-d-xylopyranoside-2′′-O-glucoside (1), 5,7,3′-trihydroxy-4′-methoxyflavone-8-C-β-d-xylopyranoside-2′′-O-gl

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Fatokun, A. A., J. O. Liu, V. L. Dawson, and T. M. Dawson. "Identification through high-throughput screening of 4'-methoxyflavone and 3',4'-dimethoxyflavone as novel neuroprotective inhibitors of parthanatos." British Journal of Pharmacology 169, no. 6 (2013): 1263–78. http://dx.doi.org/10.1111/bph.12201.

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Dej-adisai, Sukanya, Kedsaraporn Parndaeng, Chatchai Wattanapiromsakul, and Jae Sung Hwang. "Three New Isoprenylated Flavones from Artocarpus chama Stem and Their Bioactivities." Molecules 27, no. 1 (2021): 3. http://dx.doi.org/10.3390/molecules27010003.

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Phytochemical investigation of Artocarpus chama stem was performed by chromatographic techniques, resulting from the isolation and structure elucidation of three new compounds, namely 3′-farnesyl-apigenin (1), 3-(hydroxyprenyl) isoetin (2), and 3-prenyl-5,7,2′,5′-tetrahydroxy-4′-methoxyflavone (3), and five known compounds, namely homoeriodictyol (4), isocycloartobilo-xanthone (5), artocarpanone (6), naringenin (7), and artocarpin (8). From the screening result, A. chama extract showed a potent tyrosinase inhibitory effect. Ihe isolated compounds 1, 4 and 6 also exhibited tyrosinase inhibition

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Rauf, Abdur, Umer Rashid, Zuneera Akram, et al. "In vivo analgesic, anti-inflammatory, sedative, muscle relaxant activities, and docking studies of 3’,4’,7,8-tetrahydroxy-3-methoxyflavone isolated from Pistacia chinensis." Drug Target Insights 18, no. 1 (2024): 47–53. http://dx.doi.org/10.33393/dti.2024.2745.

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Background: Pistacia chinensis is extensively employed in traditional medicine. This study aimed to isolate and evaluate the therapeutic effects of 3’4’78-tetrahydroxy-3-methoxyflavone from P. chinensis crude extract. Materials and Methods: The study utilized column chromatography for isolation. The plant extract and its isolated compound were assessed for in vivo analgesic (hot plate model), anti-inflammatory (carrageenan-induced paw edema), sedative (open field model), and muscle relaxing properties (inclined plane and traction test). Results: In the thermal-induced analgesic model, a signif

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Dimitriadis, Kyriakos Michail, Olga Tsiftsoglou, Dimitra Hadjipavlou-Litina, Mohammad Arfan, and Diamanto Lazari. "Phytochemical Study of the Plant Centaurea bruguieriana (DC.) Hand.-Mazz. subsp. belangeriana (DC.) Bornm. of the Family Asteraceae." Separations 11, no. 11 (2024): 319. http://dx.doi.org/10.3390/separations11110319.

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The aim of this study is to isolate and identify the secondary metabolites of the aerial part of the plant Centaurea bruguieriana (DC.) Hand. -Mazz. subsp. belangeriana (DC.) Bornm. (Centaurea phyllocephala) (Asteraceae), and to study the biological activities of the extracts and isolated compounds with in vitro tests. With the use of chromatography and spectroscopy we identified three elemanolides: 8α-O-(3,4-dihydroxy-2-methylenebutanoyloxy) dehydromelitensine (1), 8α-O-(3-hydroxy-4-acetoxy-2-methylene-butanoyloxy) dehydromelitensine (2) and methyl 6α,8α,15-trihydroxyelema-1,3,11(13)-trien-12

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Dymarska, Monika, Tomasz Janeczko, and Edyta Kostrzewa-Susłow. "Glycosylation of Methoxylated Flavonoids in the Cultures of Isaria fumosorosea KCH J2." Molecules 23, no. 10 (2018): 2578. http://dx.doi.org/10.3390/molecules23102578.

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Flavonoids are widely described plant secondary metabolites with high and diverse pro-health properties. In nature, they occur mostly in the form of glycosides. Our research showed that an excellent way to obtain the sugar derivatives of flavonoids is through biotransformations with the use of entomopathogenic filamentous fungi as biocatalysts. In the current paper, we described the biotransformations of five methoxylated flavonoid compounds (2′-methoxyflavanone, 3′-methoxyflavanone, 4′-methoxyflavanone, 6-methoxyflavanone, and 6-methoxyflavone) in cultures of Isaria fumosorosea KCH J2. As a r

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Asyakina, Lyudmila, Stanislav Sukhikh, Svetlana Ivanova, et al. "Determination of the Qualitative Composition of Biologically-Active Substances of Extracts of In Vitro Callus, Cell Suspension, and Root Cultures of the Medicinal Plant Rhodiola rosea." Biomolecules 11, no. 3 (2021): 365. http://dx.doi.org/10.3390/biom11030365.

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The results of the qualitative composition analysis of the dried biomass extracts of in vitro callus, cell suspension, and root cultures show that the main biologically active substances (BAS) in the medicinal plant, Rhodiola rosea, are 6-C-(1-(4-hydroxyphenyl)ethyl)aromadendrin (25 mg, yield 0.21%), 2-(3,7-dihydroxy-2-(2-hydroxypropan-2-yl)-2,3-dihydrobenzofuran-5-yl)-6,7-dihydroxychroman-4-one (23 mg, yield 0.2%), 2-(3,4-dimethoxyphenyl)-5,7-dimethoxychroman-4-one (175 mg, yield 1.5%), 5,7-dihydroxy-2-(4-hydroxy-3-(2-(4-hydroxyphenyl)-4-oxo-4H-chromen-6-yl)phenyl)-4H-chromen-4-one (45 mg, yi

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Dibwe, Dya Fita, Suresh Awale, Hiroyuki Morita, and Yasuhiro Tezuka. "Anti-austeritic Constituents of the Congolese Medicinal Plant Aframomum melegueta." Natural Product Communications 10, no. 6 (2015): 1934578X1501000. http://dx.doi.org/10.1177/1934578x1501000650.

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In the course of our search for anticancer agents based on a novel anti-austerity strategy, we found that the CHCl3 extract of the roots of Aflamomum melegueta (Zingiberaceae), collected in the Democratic Republic of Congo, killed PANC-1 human pancreatic cancer cells preferentially in nutrient-deprived medium (NDM). Phytochemical investigation of the CHCl3 extract led to the isolation of seven known compounds [(-)-buplerol (1), (-)-arctigenin (2), ( E)-14-hydroxy-15-norlabda-8(17),12-dien-16-al (3), labda-8(17),12-dien-15,16-dial (4), 16-oxo-8(17),12( E)-labdadien-15-oic acid (5), 5-hydroxy-7-

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Fang, Yangyang, Wei Xiang, Jinwei Cui, Bining Jiao, and Xuesu Su. "Anti-Inflammatory Properties of the Citrus Flavonoid Diosmetin: An Updated Review of Experimental Models." Molecules 29, no. 7 (2024): 1521. http://dx.doi.org/10.3390/molecules29071521.

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Inflammation is an essential contributor to various human diseases. Diosmetin (3′,5,7-trihydroxy-4′-methoxyflavone), a citrus flavonoid, can be used as an anti-inflammatory agent. All the information in this article was collected from various research papers from online scientific databases such as PubMed and Web of Science. These studies have demonstrated that diosmetin can slow down the progression of inflammation by inhibiting the production of inflammatory mediators through modulating related pathways, predominantly the nuclear factor-κB (NF-κB) signaling pathway. In this review, we discus

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Islam, M. Tofazzal. "Variation in Chemotactic Preferences of Aphanomyces cochlioides Zoospores to Flavonoids." Zeitschrift für Naturforschung C 64, no. 11-12 (2009): 847–52. http://dx.doi.org/10.1515/znc-2009-11-1215.

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The zoospores of the phytopathogenic Aphanomyces cochlioides are chemotactically attracted by a host-specific flavone, cochliophilin A (5-hydroxy-6,7-methylenedioxyflavone), and repelled from the mammalian estrogens or estrogenic compounds. This study further examined the responses of A. cochlioides zoospores to some flavonoids structurally related to cochliophilin A or compounds known as phytoestrogens. The bioassay revealed that some synthetic flavones (such as 6-methyl-4'-methoxyflavone, 3-hydroxy-4´methoxyfl avone, 7-hydroxy- 5-methylflavone, 3-hydroxy-4´methoxy-6-methylflavone) elicited a

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