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Relevant bibliographies by topics / 3' untranslated region (3'UTR)

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Academic literature on the topic '3' untranslated region (3'UTR)'

Author: Grafiati

Published: 4 June 2021

Last updated: 1 February 2022

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Journal articles on the topic "3' untranslated region (3'UTR)"

1

Pan, FengHua, XueXiang Liu, JuFang Huang, and Wei Tian. "Characterization of 3′untranslated region (3′UTR) of the MICB gene." Human Immunology 74, no. 6 (2013): 746–50. http://dx.doi.org/10.1016/j.humimm.2013.01.028.

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López de Silanes, Isabel, María Paz Quesada, and Manel Esteller. "Aberrant Regulation of Messenger RNA 3′-Untranslated Region in Human Cancer." Analytical Cellular Pathology 29, no. 1 (2007): 1–17. http://dx.doi.org/10.1155/2007/586139.

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The messenger RNA 3′-untranslated region (3′UTR) is emerging as critically important in regulating gene expression at posttranscriptional levels. The 3′UTR governs gene expression via orchestrated interactions between mRNA structural components (cis-elements) and specific trans-acting factors (RNA-binding proteins and non-coding RNAs). Alterations in any of these components can lead to disease. Here, we review the mutations in 3′UTR regulatory sequences as well as the aberrant levels, subcellular localization, and posttranslational modifications of trans-acting factors that can promote or enha

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3

Tanguay, R. L., and D. R. Gallie. "Translational efficiency is regulated by the length of the 3' untranslated region." Molecular and Cellular Biology 16, no. 1 (1996): 146–56. http://dx.doi.org/10.1128/mcb.16.1.146.

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All polyadenylated mRNAs contain sequence of variable length between the coding region and the poly(A) tail. Little has been done to establish what role the length of the 3' untranslated region (3'UTR) plays in posttranscriptional regulation. Using firefly luciferase (luc) reporter mRNA in transiently transfected Chinese hamster ovary (CHO) cells, we observed that the addition of a poly(A) tail increased expression 97-fold when the length of the 3'UTR was 19 bases but that its stimulatory effect was only 2.3-fold when the length of the 3'UTR was increased to 156 bases. The effect of the luc 3'

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Polacek, Charlotta, and A. Michael Lindberg. "Genetic characterization of the coxsackievirus B2 3′ untranslated region." Journal of General Virology 82, no. 6 (2001): 1339–48. http://dx.doi.org/10.1099/0022-1317-82-6-1339.

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The secondary structure of the 3′ untranslated region (3′UTR) of picornaviruses is thought to be important for the initiation of negative-strand RNA synthesis. In this study, genetic and biological analyses of the 3′ terminus of coxsackievirus B2 (CVB2), which differs from other enteroviruses due to the presence of five additional nucleotides prior to the poly(A) tail, is reported. The importance of this extension was investigated using a 3′UTR mutant lacking the five nucleotides prior to the poly(A) tail and containing two point mutations. The predicted secondary structure within the 3′UTR of

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Wang, Wen Yi, Wei Tian, Xue Xiang Liu, and Li Xin Li. "HLA-G coding region and 3′untranslated region (3′UTR) in two Chinese Han populations." Immunology Letters 176 (August 2016): 65–71. http://dx.doi.org/10.1016/j.imlet.2016.05.017.

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Cybulsky, Andrey V., Tomoko Takano, Joan Papillon, et al. "The 3′-untranslated region of the Ste20-like kinase SLK regulates SLK expression." American Journal of Physiology-Renal Physiology 292, no. 2 (2007): F845—F852. http://dx.doi.org/10.1152/ajprenal.00234.2006.

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Ste20-like kinase, SLK, a germinal center kinase found in kidney epithelial cells, signals to promote apoptosis. Expression of SLK mRNA and protein and kinase activity are increased during kidney development and recovery from ischemic acute renal failure. The 3′-untranslated region (3′-UTR) of SLK mRNA contains multiple adenine and uridine-rich elements, suggesting that 3′-UTR may regulate mRNA stability. This was confirmed in COS cell transient transfection studies, which showed that expression of the SLK open-reading frame plus 3′-UTR mRNA was reduced by 35% relative to the open-reading fram

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Black, B. L., J. Lu, and E. N. Olson. "The MEF2A 3' untranslated region functions as a cis-acting translational repressor." Molecular and Cellular Biology 17, no. 5 (1997): 2756–63. http://dx.doi.org/10.1128/mcb.17.5.2756.

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Myocyte enhancer factor 2 (MEF2) proteins serve as important muscle transcription factors. In addition, MEF2 proteins have been shown to potentiate the activity of other cell-type-specific transcription factors found in muscle and brain tissue. While transcripts for MEF2 factors are widely expressed in a variety of cells and tissues, MEF2 proteins and binding activity are largely restricted to skeletal, smooth, and cardiac muscle and to brain. This disparity between MEF2 protein and mRNA expression suggests that translational control may play an important role in regulating MEF2 expression. In

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Kim, Hye-Ran, Myung-Geun Shin, Sun-Seog Kweon, et al. "The Prohibitin 3′ Untranslated Region Polymorphisms Are Associated with AML Susceptibility." Blood 114, no. 22 (2009): 5038. http://dx.doi.org/10.1182/blood.v114.22.5038.5038.

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Abstract Abstract 5038 The prohibitin gene, which is located on human chromosome 17q21 encodes a certain regulatory RNA molecule responsible for inhibitory effects and the respective tumor suppressor function. Common C/T and A/G polymorphisms occur at nucleotide 10701 and 10730 respectively in the 3' untranslated region (UTR) of the prohibitin gene. Recent findings indicate that presence of at least one mutant allele within the 3' UTR prohibitin gene polymorphism causes inactivation of bioactive RNA, resulting in loss of its pro-apoptotic function and subsequent risk for malignant growth. Thes

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Newburn, Laura R., Baodong Wu, and K. Andrew White. "Investigation of Novel RNA Elements in the 3′UTR of Tobacco Necrosis Virus-D." Viruses 12, no. 8 (2020): 856. http://dx.doi.org/10.3390/v12080856.

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RNA elements in the untranslated regions of plus-strand RNA viruses can control a variety of viral processes including translation, replication, packaging, and subgenomic mRNA production. The 3′ untranslated region (3′UTR) of Tobacco necrosis virus strain D (TNV-D; genus Betanecrovirus, family Tombusviridae) contains several well studied regulatory RNA elements. Here, we explore a previously unexamined region of the viral 3′UTR, the sequence located upstream of the 3′-cap independent translation enhancer (3′CITE). Our results indicate that (i) a long-range RNA–RNA interaction between an intern

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Leathers, V., R. Tanguay, M. Kobayashi, and D. R. Gallie. "A phylogenetically conserved sequence within viral 3' untranslated RNA pseudoknots regulates translation." Molecular and Cellular Biology 13, no. 9 (1993): 5331–47. http://dx.doi.org/10.1128/mcb.13.9.5331.

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Both the 68-base 5' leader (omega) and the 205-base 3' untranslated region (UTR) of tobacco mosaic virus (TMV) promote efficient translation. A 35-base region within omega is necessary and sufficient for the regulation. Within the 3' UTR, a 52-base region, composed of two RNA pseudoknots, is required for regulation. These pseudoknots are phylogenetically conserved among seven viruses from two different viral groups and one satellite virus. The pseudoknots contained significant conservation at the secondary and tertiary levels and at several positions at the primary sequence level. Mutational a

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Dissertations / Theses on the topic "3' untranslated region (3'UTR)"

1

Zhang, Yue. "Functional analysis of the TIMP3 3'-untranslated region (UTR)." Thesis, University of East Anglia, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.514336.

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Albino, Christine D. "RNA-protein interactions within the 3'untranslated region (3'UTR) of the human multidrug resistance type 1 (MDR1) mRNA." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape4/PQDD_0020/MQ54160.pdf.

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Johnson, Reed Findley. "Characterization of the 3' terminal 42 nucleotide host protein binding element of the mouse hepatitis virus 3' untranslated region." Texas A&M University, 2003. http://hdl.handle.net/1969/125.

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Pedder, Christopher. "Studies of protein binding to the three prime untranslated region (3'UTR) of glucose transporter mRNA." Thesis, University of Newcastle Upon Tyne, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.500914.

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As part of gene exptession within the cell, the regulation of mRNA stability, translation and transport is facilitated by trans-acting proteins that bind to cis-acting signals, present mainly within the 3'UTR. These processes can all contribute to the localisation of a transcript, vital in the development of many eukaryotic cell types, including oocytes, fibroblasts and epithelial cells. The majority of mRNA locahsation studies have concerned mRNAs encoding cytoplasmic proteins. Recent studies, however, have also shown that mRNAs encoding membrane and secreted proteins can also be localised. R

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Cheung, Foo. "The 3' untranslated region of the PrP gene." Thesis, University of Edinburgh, 1997. http://hdl.handle.net/1842/13370.

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The use of transgenic models in recent years has shown that there is a relationship between PrP expression level and disease progression. Lower-than-normal expression leads to extended incubation period and clinical phase (Beuler, 1993; Manson et al., 1994). In contrast, overexpression shortens incubation period or generates novel neurological syndromes associated with degeneration of skeletal muscle, peripheral nerves and the CNS (Westaway et al., 1994). Natural differences in expression of PrP<SUP>C</SUP> resulting from a variety of mutations within the promoter, enhancer, intron or non-codi

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Tamburino, Alex M. "A Gene-Centered Method For Mapping 3’UTR-RBP Interactions: A Dissertation." eScholarship@UMMS, 2008. http://escholarship.umassmed.edu/gsbs_diss/793.

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Interactions between 3´ untranslated regions (UTRs) and RNA-binding proteins (RBPs) play critical roles in post-transcriptional gene regulation. Metazoan genomes encode hundreds of RBPs and thousands of 3’ UTRs have been experimentally identified, yet the spectrum of interactions between 3´UTRs and RBPs remains largely unknown. Several methods are available to map these interactions, including protein-centered methods such as RBP immunoprecipitation (RIP) and cross-link immunoprecipitation (CLIP), yeast three-hybrid assays and RNAcompete. However, there is a paucity of RNA-centered approaches

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Tamburino, Alex M. "A Gene-Centered Method For Mapping 3’UTR-RBP Interactions: A Dissertation." eScholarship@UMMS, 2015. https://escholarship.umassmed.edu/gsbs_diss/793.

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Interactions between 3´ untranslated regions (UTRs) and RNA-binding proteins (RBPs) play critical roles in post-transcriptional gene regulation. Metazoan genomes encode hundreds of RBPs and thousands of 3’ UTRs have been experimentally identified, yet the spectrum of interactions between 3´UTRs and RBPs remains largely unknown. Several methods are available to map these interactions, including protein-centered methods such as RBP immunoprecipitation (RIP) and cross-link immunoprecipitation (CLIP), yeast three-hybrid assays and RNAcompete. However, there is a paucity of RNA-centered approaches

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Wiklund, Lisa. "Role of the 3'UTR in translation and stability of HCV and HPV mRNAs." Doctoral thesis, Uppsala University, Department of Medical Biochemistry and Microbiology, 2002. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3017.

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<p>Virus mRNAs can be divided into functional regions. The focus of this thesis will be to investigate the function of one of these regions, the 3’ untranslated region (UTR). The 3’UTR of HCV contains a U-rich element and the late 3’UTR of HPV-1 contains an AU-rich element. The roles of these regions in translation and stability of HCV and HPV have been studied. </p><p>A method was established for studying translation of HCV mRNA in living cells. Noninfectious minivirus clones were synthesised <i>in vitro </i>and were transfected into cells by electroporation. This made it possible to bypass t

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Einarsson, Ellen. "Evaluation of 5´- and 3´-UTR Translation Enhancing Sequences to Improve Translation of Proteins in CHO Cells." Thesis, Linköpings universitet, Teknisk biologi, 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-150363.

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The purpose of this project was to identify and evaluate nucleotide sequences enhancing translation of proteins in Chinese hamster ovary (CHO) cells. Candidate sequences were placed in the 5´-untranslated region (UTR) or 3´ UTR respectively and evaluated in a CHO-based expression system with a fluorescent Fc-fusion protein as a model protein.Five plasmid vectors were constructed, two of which designed to have a randomized nucleotide library in their 5´ and 3´ UTR respectively, and three of which designed to hold varying repeats of a known enhancing translation (ET) sequence in their 5´ or 3´ U

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Vadlamani, Sirisha. "Study of 3'-Untranslated Region of Inducible Nitric Oxide Synthase and Identification of Other Targets of Gait Pathway." Cleveland State University / OhioLINK, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=csu1227227638.

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Books on the topic "3' untranslated region (3'UTR)"

1

Albino, Christine D. RNA-protein interactions within the 3'untranslated region (3'UTR) of the human multidrug resistance type 1 (MDR1). National Library of Canada, 2000.

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2

Pontrelli, Louisa. Role of the 5' and 3' untranslated regions in translational control of apolipoprotein B mRNA. National Library of Canada, 2001.

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3

Barrett, Lucy W., Sue Fletcher, and Steve D. Wilton. Untranslated Gene Regions and Other Non-coding Elements. Springer Basel, 2013. http://dx.doi.org/10.1007/978-3-0348-0679-4.

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Mawji, Imtiaz A. Post-transcriptional regulation of human endothelin-1 by the 3'-untranslated region in health and disease. 2005.

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5

The effects of heat shock on RNA structure and stability in D. melanogaster: A study of processes involving the 3' untranslated region of hsp70 RNA. 1993.

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Book chapters on the topic "3' untranslated region (3'UTR)"

1

Hou, Jeff Jia Cheng, Michael Song, Trent P. Munro, and Peter P. Gray. "Analysis of Protein Expression via Alternate 3’ Untranslated Region (UTR) Signals Through the Use of Site Specific Recombination." In Proceedings of the 21st Annual Meeting of the European Society for Animal Cell Technology (ESACT), Dublin, Ireland, June 7-10, 2009. Springer Netherlands, 2011. http://dx.doi.org/10.1007/978-94-007-0884-6_8.

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Boutaud, Olivier, Dan A. Dixon, John A. Oates, and Hitoshi Sawaoka. "Tristetrapolin Binds to the COX-2 mRNA 3’ Untranslated Region in Cancer Cells." In Advances in Experimental Medicine and Biology. Springer US, 2003. http://dx.doi.org/10.1007/978-1-4419-9194-2_32.

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Williams, G. D., R. Y. Chang, and D. A. Brian. "Evidence for a Pseudoknot in the 3′ Untranslated Region of the Bovine Coronavirus Genome." In Advances in Experimental Medicine and Biology. Springer US, 1995. http://dx.doi.org/10.1007/978-1-4615-1899-0_81.

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Hsue, Bilan, and Paul S. Masters. "An Essential Secondary Structure in the 3’ Untranslated Region of the Mouse Hepatitis Virus Genome." In Advances in Experimental Medicine and Biology. Springer US, 1998. http://dx.doi.org/10.1007/978-1-4615-5331-1_39.

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5

Collisson, Ellen W., Minglong Zhou, Paul Gershon, and Jyothi Jayaram. "Infectious Bronchitis Virus Nucleocapsid Protein Interactions with the 3’ Untranslated Region of Genomic RNA Depend on Uridylate Bases." In Advances in Experimental Medicine and Biology. Springer US, 2001. http://dx.doi.org/10.1007/978-1-4615-1325-4_99.

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6

Arnemann, J. "Untranslatierte Region (UTR)." In Springer Reference Medizin. Springer Berlin Heidelberg, 2019. http://dx.doi.org/10.1007/978-3-662-48986-4_3638.

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Arnemann, J. "Untranslatierte Region (UTR)." In Lexikon der Medizinischen Laboratoriumsdiagnostik. Springer Berlin Heidelberg, 2018. http://dx.doi.org/10.1007/978-3-662-49054-9_3638-1.

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8

Shanmukhappa, Kumar, Fahad Majhdi, and Sanjay Kapil. "Production, Characterization, and Uses of Monoclonal Antibodies against Porcine Reproductive and Respiratory Syndrome Virus 3′ Untranslated Region and Nucleoprotein RNA Binding Proteins." In Advances in Experimental Medicine and Biology. Springer US, 2001. http://dx.doi.org/10.1007/978-1-4615-1325-4_86.

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Akbergenov, R. Z., S. S. Zhanybekova, N. S. Polimbetova, K. I. Madin, T. Hohn, and B. K. Iskakov. "Complementary Interaction Between the Central Domain of 18S rRNA and the 5’ Untranslated Region of mRNA Enhances Translation Efficiency in Plants." In Cell-Free Protein Expression. Springer Berlin Heidelberg, 2003. http://dx.doi.org/10.1007/978-3-642-59337-6_24.

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Majhad I, Fahad, and Sanjay Kapil. "Interactions of Cellular Proteins with the Positive Strand of 3’-Untranslated Region RNA and the Nucleoprotein Gene of Porcine Reproductive and Respiratory Syndrome Virus." In Advances in Experimental Medicine and Biology. Springer US, 2001. http://dx.doi.org/10.1007/978-1-4615-1325-4_94.

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Conference papers on the topic "3' untranslated region (3'UTR)"

1

Shukla, Girish C., Kavleen Sikand, and Jey S. Ebron. "Abstract 3196: Androgen receptor 3’ untranslated region (UTR): a conundrum and a significant therapeutic opportunity." In Proceedings: AACR 104th Annual Meeting 2013; Apr 6-10, 2013; Washington, DC. American Association for Cancer Research, 2013. http://dx.doi.org/10.1158/1538-7445.am2013-3196.

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Berzal-Herranz, Alfredo, Ana Hinckley Boned, and Cristina Romero-López. "Selection of RNA aptamers targeting the 3’ untranslated region of the West Nile Virus genome." In 6th International Electronic Conference on Medicinal Chemistry. MDPI, 2020. http://dx.doi.org/10.3390/ecmc2020-07303.

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Yu, Xinfeng, Marjorie L. Beggs, Ishwori B. Dhakal, et al. "Abstract 916: Functional significance of sulfotransferase 1A1 polymorphisms in the 3’ untranslated region in determination of enzymatic activity." In Proceedings: AACR 101st Annual Meeting 2010‐‐ Apr 17‐21, 2010; Washington, DC. American Association for Cancer Research, 2010. http://dx.doi.org/10.1158/1538-7445.am10-916.

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4

To, Kenneth K. W. "Abstract LB131: Shortening of mRNA 3′ untranslated region mediates simultaneous overexpression of ABCG2 and CD133 in putative cancer stem cells." In Proceedings: AACR Annual Meeting 2021; April 10-15, 2021 and May 17-21, 2021; Philadelphia, PA. American Association for Cancer Research, 2021. http://dx.doi.org/10.1158/1538-7445.am2021-lb131.

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Kim, Connie E., Kam-Meng Tchou-Wong, and William Rom. "Investigating Single Nucleotide Polymorphisms In MiRNA-Binding Sites In The K-RAS 3' Untranslated Region As A Novel Biomarker For Lung Cancer." In American Thoracic Society 2012 International Conference, May 18-23, 2012 • San Francisco, California. American Thoracic Society, 2012. http://dx.doi.org/10.1164/ajrccm-conference.2012.185.1_meetingabstracts.a6349.

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Ngo, K. Y., D. Lynch, J. Gitscher, N. Ciavarella, Z. Ruggeri, and T. Zimmerman. "HOMOZYGOUS AND HETEROZYGOUS COMPLETE DELETIONS OF THE VON WILLEBRAND FACTOR GENE CODING REGION IN SEVERE VON WILLEBRAND DISEASE AND CARRIERS." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643931.

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Severe von Willebrand disease (vWD) is characterized by undetectable levels of von Willebrand factor (vWF), or trace amounts, in plasma and tissue stores. We have studied the genomic DNA of ten affected individuals from five families with this disorder using two cDNA probes. One probe extended from 175 base pairs of the 5’ untranslated region to the nucleotides encoding amino acid 618 of pro-vWF; the second extended from the nucleotides encoding amino acid 2225 of pro-vWF to 100 bp into the 3’ untranslated region. Three variants of the disorder were identified. Southern blots of restriction en

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Ploos van Amstel, J. K., A. L. van der Zanden, E. Bakker, P. H. Reitsma, and R. M. Bertina. "INDEPENDENT ISOLATION OF HUMAN PROTEIN S cDNA AND THE ASSIGNMENT OF THE GENE TO CHROMOSOME 3." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644638.

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Protein S is a vitamin K-dependent glycoprotein, that serves as a cofactor of activated protein C. A hereditary deficiency in protein S is associated with an increased risk for the development of venous thrombosis. The deficiency is inherited as an autosomal dominant trait. We isolated a cDNA coding for protein S and assigned its gene to chromosome 3.A human liver cDNA library in phage xgtll (complexity 1.2 × 106 , D. Stafford, Chapel Hill) was screened by using immuno-purifiedpolyclonal anti-protein S IgG as a probe. Approximately 1.5 x 10 recombinants of the amplified library were screened.

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Silva, B. O., A. N. Correia, T. F. Barros, et al. "3′ untranslated region A>C (rs3212227) polymorphism of Interleukin 12B gene as a potential risk factor for Hodgkin’s lymphoma in Brazilian children and adolescents." In ISCAYAHL 2020. © Georg Thieme Verlag KG, 2020. http://dx.doi.org/10.1055/s-0040-1701839.

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Jenny, Richard J., Debra D. Pittman, John J. Toole, Ronald W. Kriz, Randal J. Kaufman, and Kenneth G. Mann. "THE COMPLETE AMINO ACID SEQUENCE OF HUMAN FACTOR V." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643887.

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cDNA clones encoding human factor V have been isolated and sequenced. The cDNA sequence of factor V obtained from overlapping clones includes a 6672 bp coding region, a 90 bp 5'-untranslated region and a 163 bp 3’-untranslated region including a poly-A tail. The deduced amino acid sequence consists of 2224 amino acids including a 28 amino acid leader peptide. A direct comparison to human factor VIII reveals considerable homology between both proteins with respect to amino acid sequence and domain structure. A triplicated "A" domain and duplicated "C" domain show an approximate 40% identity to

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Song, Fengju, Hong Zheng, Ben Liu, et al. "Abstract A1: An miR‐502 binding site single‐nucleotide polymorphism in the 3′‐untranslated region of the SET8 gene is associated with early age of breast cancer onset." In Abstracts: AACR International Conference on Frontiers in Cancer Prevention Research‐‐ Dec 6–9, 2009; Houston, TX. American Association for Cancer Research, 2010. http://dx.doi.org/10.1158/1940-6207.prev-09-a1.

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