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Dissertations / Theses on the topic '3' untranslated region (3'UTR)'

Author: Grafiati

Published: 4 June 2021

Last updated: 1 February 2022

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1

Zhang, Yue. "Functional analysis of the TIMP3 3'-untranslated region (UTR)." Thesis, University of East Anglia, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.514336.

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2

Albino, Christine D. "RNA-protein interactions within the 3'untranslated region (3'UTR) of the human multidrug resistance type 1 (MDR1) mRNA." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape4/PQDD_0020/MQ54160.pdf.

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3

Johnson, Reed Findley. "Characterization of the 3' terminal 42 nucleotide host protein binding element of the mouse hepatitis virus 3' untranslated region." Texas A&M University, 2003. http://hdl.handle.net/1969/125.

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4

Pedder, Christopher. "Studies of protein binding to the three prime untranslated region (3'UTR) of glucose transporter mRNA." Thesis, University of Newcastle Upon Tyne, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.500914.

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As part of gene exptession within the cell, the regulation of mRNA stability, translation and transport is facilitated by trans-acting proteins that bind to cis-acting signals, present mainly within the 3'UTR. These processes can all contribute to the localisation of a transcript, vital in the development of many eukaryotic cell types, including oocytes, fibroblasts and epithelial cells. The majority of mRNA locahsation studies have concerned mRNAs encoding cytoplasmic proteins. Recent studies, however, have also shown that mRNAs encoding membrane and secreted proteins can also be localised. R

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5

Cheung, Foo. "The 3' untranslated region of the PrP gene." Thesis, University of Edinburgh, 1997. http://hdl.handle.net/1842/13370.

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The use of transgenic models in recent years has shown that there is a relationship between PrP expression level and disease progression. Lower-than-normal expression leads to extended incubation period and clinical phase (Beuler, 1993; Manson et al., 1994). In contrast, overexpression shortens incubation period or generates novel neurological syndromes associated with degeneration of skeletal muscle, peripheral nerves and the CNS (Westaway et al., 1994). Natural differences in expression of PrP<SUP>C</SUP> resulting from a variety of mutations within the promoter, enhancer, intron or non-codi

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6

Tamburino, Alex M. "A Gene-Centered Method For Mapping 3’UTR-RBP Interactions: A Dissertation." eScholarship@UMMS, 2008. http://escholarship.umassmed.edu/gsbs_diss/793.

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Interactions between 3´ untranslated regions (UTRs) and RNA-binding proteins (RBPs) play critical roles in post-transcriptional gene regulation. Metazoan genomes encode hundreds of RBPs and thousands of 3’ UTRs have been experimentally identified, yet the spectrum of interactions between 3´UTRs and RBPs remains largely unknown. Several methods are available to map these interactions, including protein-centered methods such as RBP immunoprecipitation (RIP) and cross-link immunoprecipitation (CLIP), yeast three-hybrid assays and RNAcompete. However, there is a paucity of RNA-centered approaches

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7

Tamburino, Alex M. "A Gene-Centered Method For Mapping 3’UTR-RBP Interactions: A Dissertation." eScholarship@UMMS, 2015. https://escholarship.umassmed.edu/gsbs_diss/793.

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Interactions between 3´ untranslated regions (UTRs) and RNA-binding proteins (RBPs) play critical roles in post-transcriptional gene regulation. Metazoan genomes encode hundreds of RBPs and thousands of 3’ UTRs have been experimentally identified, yet the spectrum of interactions between 3´UTRs and RBPs remains largely unknown. Several methods are available to map these interactions, including protein-centered methods such as RBP immunoprecipitation (RIP) and cross-link immunoprecipitation (CLIP), yeast three-hybrid assays and RNAcompete. However, there is a paucity of RNA-centered approaches

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8

Wiklund, Lisa. "Role of the 3'UTR in translation and stability of HCV and HPV mRNAs." Doctoral thesis, Uppsala University, Department of Medical Biochemistry and Microbiology, 2002. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3017.

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<p>Virus mRNAs can be divided into functional regions. The focus of this thesis will be to investigate the function of one of these regions, the 3’ untranslated region (UTR). The 3’UTR of HCV contains a U-rich element and the late 3’UTR of HPV-1 contains an AU-rich element. The roles of these regions in translation and stability of HCV and HPV have been studied. </p><p>A method was established for studying translation of HCV mRNA in living cells. Noninfectious minivirus clones were synthesised <i>in vitro </i>and were transfected into cells by electroporation. This made it possible to bypass t

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9

Einarsson, Ellen. "Evaluation of 5´- and 3´-UTR Translation Enhancing Sequences to Improve Translation of Proteins in CHO Cells." Thesis, Linköpings universitet, Teknisk biologi, 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-150363.

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The purpose of this project was to identify and evaluate nucleotide sequences enhancing translation of proteins in Chinese hamster ovary (CHO) cells. Candidate sequences were placed in the 5´-untranslated region (UTR) or 3´ UTR respectively and evaluated in a CHO-based expression system with a fluorescent Fc-fusion protein as a model protein.Five plasmid vectors were constructed, two of which designed to have a randomized nucleotide library in their 5´ and 3´ UTR respectively, and three of which designed to hold varying repeats of a known enhancing translation (ET) sequence in their 5´ or 3´ U

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10

Vadlamani, Sirisha. "Study of 3'-Untranslated Region of Inducible Nitric Oxide Synthase and Identification of Other Targets of Gait Pathway." Cleveland State University / OhioLINK, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=csu1227227638.

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11

Pinto, Pedro Alexandre Borges. "The role of Drosophila melanogaster polo 3' untranslated region in gene expression." Tese, Instituto de Ciências Biomédicas Abel Salazar, 2007. http://hdl.handle.net/10216/7195.

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12

Pinto, Pedro Alexandre Borges. "The role of Drosophila melanogaster polo 3' untranslated region in gene expression." Doctoral thesis, Instituto de Ciências Biomédicas Abel Salazar, 2007. http://hdl.handle.net/10216/7195.

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13

Dickson, John Robert. "The Role of the Human Tau 3'-Untranslated Region in Regulating Tau Expression." Thesis, Harvard University, 2013. http://dissertations.umi.com/gsas.harvard:11070.

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The microtubule-associated protein tau forms pathological neuronal filaments in Alzheimer's disease (AD) and other neurodegenerative disorders, known collectively as tauopathies. Previous studies in transgenic mouse models of AD suggest that reducing tau expression may be safe and beneficial for the prevention or treatment of AD and possibly other tauopathies. As a first step toward identifying novel therapeutic strategies to reduce tau levels, the studies presented in this dissertation aim to investigate the role of the human tau 3'-untranslated region (3'-UTR) in regulating tau expression.

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14

Ang, Caroline Wan-Yin. "The myotonic distrophy kinase 3' untranslated region and its effect on gene expression." Thesis, University of Ottawa (Canada), 1995. http://hdl.handle.net/10393/9785.

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A mutation occurring outside the coding region in the 3$\sp\prime$UTR or the myotonic dystrophy kinase (DMK) suggests the formation of a defective gene product may not be involved in the disease process. Instead, the effect of the repeat expansion may be directed toward gene regulation or expression. In this study, investigation of the possibility or cellular factors capable of directly binding DNA or RNA revealed the presence of at least two factors in cytosolic extract. Mobility shift assays were done using an RNA probe comprising a portion of the 3$\sp\prime$UTR containing the repeat region

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15

Chaudhuri, Leena. "Manganese superoxide dismutase (MnSOD) 3'-untranslated region: a novel molecular sensor for environmental stress." Diss., University of Iowa, 2010. https://ir.uiowa.edu/etd/2682.

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Eukaryotic gene expression is a complex process and can be controlled at the level of transcription, post-transcription or translation and post-translation. In recent years, there is a growing interest in understanding the role of 3'-untranslated region (UTR) in regulating mRNA turnover and translation. The 3'-UTR harbors the poly(A) signal and post-transcriptional regulatory sequences like miRNA and AU-rich elements (AREs). The presence of multiple poly(A) sites often results in multiple transcripts; shorter transcripts correlating with more protein abundance. Manganese superoxide dismutase (

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16

Camacho, Lizeth Carolina Cordoba. "Caracterização funcional do SNP rs6917 na 3\'UTR do gene Proibitina: associação com quimiorresistência em linhagens de melanoma humano e melanoma de crescimento vertical." Universidade de São Paulo, 2018. http://www.teses.usp.br/teses/disponiveis/5/5155/tde-05062018-122246/.

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O melanoma cutâneo é um tipo de tumor formado a partir dos melanócitos, células de origem neuroectodérmica que habitam a epiderme, sendo responsáveis por sua pigmentação. Embora este tumor seja o tipo menos frequente de câncer de pele, ele está associado com altas taxas de mortalidade, principalmente devido a seu comportamento agressivo (alta capacidade metastática) e quimiorresistência aos tratamentos (quimioterapia e radioterapia). Os processos da quimiorresistência em melanoma ainda não são totalmente conhecidos. Estudos prévios de nosso grupo evidenciaram que a expressão da proteína Proibi

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17

Mahon, P. "The intracellular localisation of metallothionein isoform mRNA : role of the 3' untranslated region and the cytoskeleton." Thesis, University of Aberdeen, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.593020.

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For the purpose of creating a novel cell culture model to study the physiological significance of MT mRNA localisation and also to initially investigate the possibility of whether any other region of the MT-1 mRNA (apart from the 3' UTR) is involved in intracellular targeting. CHO cells (which do not express MT genes) were transfected with constructs consisting of the wild-type MT-1 cDNA as well as the 5' UTR and coding region of the MT-1 cDNA linked to the glutathione peroxidase (GSH-Px) 3' UTR (which is not thought to contain a localisation signal). <I>In situ</I> hybridisation using a digox

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18

Lui, Wan Thomas, and 雷雲. "An analysis of the functional significance of the 3'-untranslated region of CHOP/Gadd153 messenger RNA." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2013. http://hub.hku.hk/bib/B50899855.

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CHOP, or Gadd153, is a 29 kDa protein that plays a pivotal role in the mediation of cellular stress-induced cell death. The expression of the gene encoding CHOP/Gadd153 is regulated at both the transcriptional and post-transcriptional levels. Compared to transcription, the regulation of Chop gene expression at the post-transcriptional level is much less understood. In this study, the role played by the 3’-untranslated region of CHOP mRNA (3UTRChop) in mediating mRNA stability was examined. A reporter plasmid was constructed so that the mRNA expressed has 3UTRChop as its 3’-untranslated region

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19

Vadlamani, Sirisha. "Study of 3'-untranslated region of inducible nitric oxide synthase and identification of other targets of GAITpathway." Cleveland, Ohio : Cleveland State University, 2008.

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Thesis (M.S.)--Cleveland State University, 2008.<br>Abstracts. Title from PDF t.p. (viewed on Jan. 29, 2009). Includes bibliographical references (p. 33-36). Available online via the OhioLINK ETD Center. Also available in print.

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20

Kiri, Arpna. "The isolation and function of the 3'untranslated region of the myosin heavy chain genes of skeletal muscle." Thesis, University College London (University of London), 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.325611.

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21

Diab, Thoria. "Role of the 3' untranslated region in the post-transcriptionnal regulation of KLF6 gene expression in hepatocellular carcinoma." Toulouse 3, 2013. http://www.theses.fr/2013TOU30202.

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Krüppel-like factor 6 (KLF6) a été identifié comme gène suppresseur de tumeur impliqué dans le contrôle de la croissance, de la différentiation cellulaire et dans la mort par apoptose. L'expression de KLF6 est altérée au cours de la carcinogenèse hépatique, et cette protéine joue un rôle prépondérant dans le contrôle de la prolifération des cellules tumorales hépatiques. Nous avons étudié le rôle de la région 3'UTR de l'ARNm de KLF6 dans la régulation de son expression. Nous avons établi que la demi-vie de l'ARNm de KLF6 est fortement diminuée dans les lignées cellules dérivées du foie. La rég

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22

Argasinska, Joanna Patrycja. "Regulation of cyclin E translation in meiotically maturing Xenopus oocytes by the 3' untranslated region and translational control by CPEB." Thesis, University of Cambridge, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.614797.

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23

Gubser, Charles Conrad. "NMR structural studies of the 3' untranslated region of the U1A pre- mRNA and its interaction with the U1A protein." Thesis, University of Cambridge, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.627193.

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24

Mastroyiannopoulos, Nikolaos. "Woodchuck post-transcriptional element induces nuclear export of myotonic dystrophy 3' untranslated region transcripts and mediate the repair of muscle cell differentiation." Thesis, University of Bristol, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.500394.

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25

Cockman, Eric Michael. "Post-Transcriptional Regulation of Selenoprotein S." Case Western Reserve University School of Graduate Studies / OhioLINK, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=case1562593531805034.

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26

Motazakker, Morteza. "Characterisation of the translation efficiency and quasispecies composition of the 5'untranslated region of Hepatitis C Virus in genotype 1 and 3 infected patients." Thesis, University of Glasgow, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.414341.

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27

McMahan, Linda. "Tn1 Insertions in the 3' Untranslated Region of the ant Operon of Bacteriophage P22 Affect ant Gene Expression and Alter ant mRNA Stability: a Thesis." eScholarship@UMMS, 1985. http://escholarship.umassmed.edu/gsbs_diss/249.

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Insertion of transposable elements within an operon has been known not only to abolish expression of the gene interrupted by the insertion, but also to exert a strong polar effect on the expression of downstream genes in the same operon. In this dissertation, I have shown that insertions of the transposable ampicillin-resistance element Tn1, either in the polar or nonpolar orientation, in the 3' untranslated region of the bacteriophage P22 antirepressor (ant) operon reduce the rate of upstream ant gene expression; insertions of Tn1 in the nonpolar orientation reduce the rate of ant gene ex

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28

Kiss, Andor Joseph. "A spatial and temporal study of mRNA binding proteins specific to a 134 base CA dinucleotide-rich portion of the 3'-untranslated region from the BALB/c mouse catalase gene, Cas-1." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp04/mq28596.pdf.

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29

Sousa, Ana Cláudia Faria Curinha de. "Regulation of MCL1 alternative polyadenylationderived mRNA isoforms by microRNAs in human T cells." Master's thesis, Universidade de Aveiro, 2014. http://hdl.handle.net/10773/15280.

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Mestrado em Biologia Molecular e Celular<br>Polyadenylation is a fundamental processing step of mRNA maturation, essential for its export, stability and translation. Bioinformatic analyses have shown that 70% of human genes have several polyadenylation signals (pA signals) in the 3’untranslated region (3’UTR) that are used to produce multiple mRNA isoforms by alternative polyadenylation (APA). This process has a fundamental role in gene expression in a variety of cellular programs as well as in non-pathological conditions and diseases. When it occurs in the 3’UTR, APA gives rise to transcripts

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30

Marchese, Domenica 1986. "Post-transcriptional regulation of Alpha-synuclein and link to Parkinson's disease." Doctoral thesis, Universitat Pompeu Fabra, 2016. http://hdl.handle.net/10803/525819.

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The role of RNA processing in the pathogenesis of neurodegenerative diseases is still poorly understood. α-synuclein (SNCA) is a presynaptic neuronal protein known as the major component of Lewy bodies, the pathological hallmark of Parkinson’s disease (PD). Recent evidence suggests a link between the pathogenesis of PD and the expression of SNCA mRNA isoforms with 3’ untranslated region (3’UTR) of different lengths. The purpose of my doctoral studies was the discovery of RNA-binding proteins (RBPs) regulating SNCA at the post-transcriptional level. Using computational and experimental approach

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31

Ng, Shuk-fan. "The analysis of 5' and 3' untranslated regions (UTRS) of influenza A virus /." Click to view the E-thesis via HKUTO, 2005. http://sunzi.lib.hku.hk/hkuto/record/B35723221.

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32

Ng, Shuk-fan, and 吳淑芬. "The analysis of 5' and 3' untranslated regions (UTRS) of influenza A virus." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2005. http://hub.hku.hk/bib/B35723221.

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33

Braz, Sandra Catarina Oliveira. "Alternative polyadenylation of Rho GTPases : a gene/cell specific process." Master's thesis, Universidade de Aveiro, 2014. http://hdl.handle.net/10773/14865.

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Mestrado em Biologia Molecular e Celular<br>Alternative polyadenylation (APA) is an important mechanism of gene regulation that occurs in 70% of eukaryotic organisms. This process comprises the formation of alternative 3’ ends of an mRNA by cleavage of the pre-mRNA and polyadenylation at different sites according to the polyadenylation signals (pAs). The choice of pAs in APA is a co-transcriptional mechanism that depends on auxiliary cis- and trans-acting factors. The usage of the proximal or the distal pAs has been related to global physiologic events. It is consensually assumed that in

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34

Dalgleish, Gillian Denise. "Localisation signals within the c-myc and c-fos 3'untranslated regions." Thesis, University of Aberdeen, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.481826.

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35

Khazaipoul, Siavash. "Studies of recombinant protein expression : targeting signals, 3' untranslated regions and trans-acting factors." Thesis, University of Newcastle upon Tyne, 2011. http://hdl.handle.net/10443/2181.

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At present mammalian cell factories are being employed for recombinant protein production. However, the yields of proteins produced from such systems are often poor. This thesis describes experiments to study the effects of altering targeting signals (signal peptide) and 3’ untranslated regions (3’UTR) in an expression vector on protein expression. A variety of gene constructs containing Gaussia princeps luciferase as reporter were created using a seamless cloning method. In these constructs a variety of signal peptides, some with altered hydrophobicity, were combined with the Gaussia lucifera

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36

Steil, Benjamin Peter. "Protein primers and a telomerase-like mechanism of poliovirus RNA replication maintain the 3' end of the RNA genome /." Connect to abstract via ProQuest. Full text is not available online, 2008.

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Thesis (Ph.D. in Microbiology) -- University of Colorado Denver, 2008.<br>Typescript. Includes bibliographical references (leaves 198-225). Online version available via ProQuest Digital Dissertations.

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37

Pontrelli, Louisa. "Role of the 5' and 3' untranslated regions in translational control of apolipoprotein B mRNA." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2001. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/MQ63105.pdf.

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38

Singh, Guramrit. "Human nonsense-mediated mRNA decay is a cytoplasmic process triggered by aberrant 3'-untranslated regions." Connect to online resource, 2007. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3256455.

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39

Wiseman, J. "Relocalisation of β-globin coding sequences by myosin heavy chain and vimentin 3' untranslated regions". Thesis, University of Aberdeen, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.318982.

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The presence of a localisation signal within the 3' untranslated regions of myosin heavy chain and vimentin messenger RNAs was investigated by studying mRNA distribution in myoblasts and fibroblasts which were transfected with β-globin and chimaeric β-globin-myosin and β-globin-vimentin gene constructs. In cells transfected with constructs containing either a fragment of the β-globin gene containing both coding and 3' untranslated sequences or the β-globin coding sequences alone, <I>in situ </I>hybridisation revealed that the mRNAs transcribed from these constructs were distributed throughout

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40

Kamon, Phochana Pimpicha Patmasiriwat. "Variant analysis at 5' and 3' untranslated regions of BRCA2 in thai familial breast and ovarian cancer /." Abstract, 2004. http://mulinet3.li.mahidol.ac.th/thesis/2547/cd364/4436684.pdf.

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41

Song, Xiaomin. "Distribution and molecular characterization of 3'-UTR binding proteins specific to the (U)¦1¦5 region of Cas-1 gene." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk2/tape16/PQDD_0013/MQ28664.pdf.

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42

Ren, Zhiji. "Identification and Characterization of MicroRNA Modulators in Caenorhabditis Elegans: A Dissertation." eScholarship@UMMS, 2002. http://escholarship.umassmed.edu/gsbs_diss/835.

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MicroRNAs (miRNAs) are endogenous non-coding small RNAs that posttranscriptionally regulate gene expression primarily through binding to the 3’ untranslated region (3’UTR) of target mRNAs, and are known to play important roles in various developmental and physiological processes. The work presented in this thesis was centered on understanding how Caenorhabditis elegans miRNAs are modulated by genetic, environmental, or physiological factors and how these small RNAs function to maintain the robustness of developmental processes under stressful conditions. To identify modulators of the miRNA pat

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Ren, Zhiji. "Identification and Characterization of MicroRNA Modulators in Caenorhabditis Elegans: A Dissertation." eScholarship@UMMS, 2016. https://escholarship.umassmed.edu/gsbs_diss/835.

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MicroRNAs (miRNAs) are endogenous non-coding small RNAs that posttranscriptionally regulate gene expression primarily through binding to the 3’ untranslated region (3’UTR) of target mRNAs, and are known to play important roles in various developmental and physiological processes. The work presented in this thesis was centered on understanding how Caenorhabditis elegans miRNAs are modulated by genetic, environmental, or physiological factors and how these small RNAs function to maintain the robustness of developmental processes under stressful conditions. To identify modulators of the miRNA pat

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44

Hernando, Fuster Bárbara. "The genetic basis of sunlight sensitivity and melanoma-risk pigmentation phenotypes: The role of sex-specific genetic effects, 3' untranslated regions and melanoma susceptibility genes." Doctoral thesis, Universitat Jaume I, 2017. http://hdl.handle.net/10803/403665.

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La pigmentación basal es un rasgo de carácter poligénico con alta heredabilidad, influenciada por factores ambientales, genéticos y endocrinos. La incidencia del cáncer de piel revela una clara relación entre ciertos rasgos de pigmentación y los daños causados por la exposición solar. Además, estudios recientes muestran una diferencia tanto en las características de pigmentación así como en la prevalencia e incidencia de melanoma entre sexos. El objetivo principal de esta tesis doctoral es ampliar el conocimiento actual sobre las bases moleculares de la pigmentación humana y la predisposición

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45

Alves, Beatriz Santos Capela. "Caracterização das proteinas humanas Mov34 e PACT e analise da sua interação com o RNA do virus da dengue." [s.n.], 2008. http://repositorio.unicamp.br/jspui/handle/REPOSIP/317180.

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Orientador: Nilson Ivo Tonin Zanchin<br>Tese (doutorado) - Universidade Estadual de Campinas, Instituto de Biologia<br>Made available in DSpace on 2018-08-11T18:49:26Z (GMT). No. of bitstreams: 1 Alves_BeatrizSantosCapela_D.pdf: 5512305 bytes, checksum: 707ea6299bc24ddc6fb459520d79aeee (MD5) Previous issue date: 2008<br>Resumo: O combate à dengue atualmente está limitado praticamente aos esforços de eliminação do mosquito transmissor, o Aedes aegypti, porém esta estratégia não tem se mostrado eficiente. O desenvolvimento de novos instrumentos de combate à dengue requer, portanto, maior conhe

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46

Olsson, Malin. "Familial amyloidosis with polyneuropathy : studies of genetic factors modifying the phenotype of the disease." Doctoral thesis, Umeå universitet, Medicin, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-34128.

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Background. Familial Amyloidosis with Polyneuropathy (FAP) is an autosomal dominantly inherited systemic amyloid disease. The disease is caused by mutations in the transthyretin (TTR) gene, where close to 100 different amyloidogenic mutations have been identified. FAP is found worldwide, but endemic areas with a high frequency of patients are found in Portugal, Japan and northern Sweden. Cases from these endemic areas all share the same TTR c.148G>A, p.V50M ("V30M") mutation, but the phenotype of the disease varies between the areas, and also within the endemic areas. The mean onset of the

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47

Padmanabhan, Kiran. "Translational Control of M Phase Progression: a dissertation." eScholarship@UMMS, 2006. https://escholarship.umassmed.edu/gsbs_diss/272.

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A cell integrates mitogenic signals received at the plasma membrane with intracellular biochemical changes to direct the events of cell division. Oocytes from Xenopus laevis offer a system that allows molecular dissection of pathways controlling cell growth and division in response to extracellular cues. Xenopus oocytes, physiologically arrested in a G2 like state, respond to the hormone progesterone to reinitiate meiosis and mature into a fertilizable egg. Signals received at the oocyte membrane induce translation of dormant maternal mRNAs that not only drive meiotic entry but also maintain t

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Padmanabhan, Kiran. "Translational Control of M Phase Progression: a dissertation." eScholarship@UMMS, 2005. http://escholarship.umassmed.edu/gsbs_diss/272.

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A cell integrates mitogenic signals received at the plasma membrane with intracellular biochemical changes to direct the events of cell division. Oocytes from Xenopus laevis offer a system that allows molecular dissection of pathways controlling cell growth and division in response to extracellular cues. Xenopus oocytes, physiologically arrested in a G2 like state, respond to the hormone progesterone to reinitiate meiosis and mature into a fertilizable egg. Signals received at the oocyte membrane induce translation of dormant maternal mRNAs that not only drive meiotic entry but also maintain t

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Farley, Brian M. "Sequence and Target Specificity of the C. elegans Cell Fate Specification Factor POS-1: A Dissertation." eScholarship@UMMS, 2012. https://escholarship.umassmed.edu/gsbs_diss/629.

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In most metazoans, early embryogenesis is controlled by the translational regulation of maternally supplied mRNA. Sequence-specific RNA-binding proteins play an important role in regulating early embryogenesis, yet their specificities and regulatory targets are largely unknown. To understand how these RNA-binding proteins select their targets, my research focused on the C. elegans CCCH-type tandem zinc finger protein POS-1. Embryos lacking maternally supplied POS-1 die prior to gastrulation, and exhibit defects in the specification of pharyngeal, intestinal, and germline precursor cells. To

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Hsu, Chien-Hui, and 徐千惠. "The post-transcriptional regulation of human FGF9 3’ untranslated region (3’UTR) on FGF9 protein expression." Thesis, 2005. http://ndltd.ncl.edu.tw/handle/86659055770784835926.

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碩士<br>國立成功大學<br>分子醫學研究所<br>93<br>Post-transcriptional control, which includes determining transcript stability, level of translation, mRNA targeting, poly (A) shortening and alternative polyadenylation, has been shown to regulate protein expression via interaction of untranslated regions (5’ and 3’UTR) with regulatory proteins. Recent studies reveal the power of 3’UTR in controlling cell–fate determination, location and timing of cell division, and shaping the expression pattern during development. Fibroblast growth factor 9 (FGF9) is an autocrine/paracrine growth factor that plays important

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