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Journal articles on the topic "305.5/62089090092 b"
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Williams, Jason. "Evaluating Clean Water Act progress drivers for Idaho rivers and streams 2002–2022." PLOS Water 2, no. 8 (2023): e0000112. http://dx.doi.org/10.1371/journal.pwat.0000112.
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In the United States, the Clean Water Act (CWA) is the primary legislation driving surface water quality management. Its goal is to “restore and maintain the chemical, physical, and biological integrity of the Nation’s waters.” Section 305(b) of the CWA requires states to document CWA progress by reporting whether applicable water quality standards are achieved for all state waters every two years. Developing strategies for increasing the proportion of waters achieving standards requires diagnosing factors driving 305(b) data temporal trends. This analysis demonstrates how systematically analyzing 305(b) data in new ways can help document CWA progress (or lack thereof) and associated drivers. Idaho 305(b) data were used to evaluate the relative contribution of assessment progress and restoration to 2002–2022 Idaho 305(b) temporal trends. Assessment progress was defined as assessing unassessed waters and correcting assessment errors. Restoration was defined as changes from not achieving one or more standards to achieving all assessed standards because water quality improved. From 2002–2022, the percentage of Idaho stream kilometers achieving all assessed standards increased from 24% to 32%. Systematically evaluating reasons for stream status changes revealed this trend was driven primarily by assessment progress, specifically progress monitoring previously unassessed waters in good condition and correcting prior assessment errors. More stream km changed from impaired to unimpaired because prior assessment errors were corrected than because water quality improved. In each biennial 305(b) report ≤ 5% of all stream km changing status resulted from water quality improvement. As of 2022, more state stream km were impaired (39%) than unassessed (29%) and restoration success rates will likely become the primary driver of 305(b) temporal trends in the future. Systematically analyzing 305(b) data in new ways may help develop new empirically driven strategies for accelerating CWA progress and merits further investigation.
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Kliegel, W., L. Preu, Steven J. Rettig, and James Trotter. "Structural studies of organoboron compounds. XXIV. 5-Methyl-5-nitro-2-phenyl-1,3-dioxa-2-boracyclohexane." Canadian Journal of Chemistry 64, no. 9 (1986): 1855–58. http://dx.doi.org/10.1139/v86-305.
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The title compound was prepared according to the literature in order to determine whether it has a bicyclic cage structure resulting from intramolecular O → B coordination or a monocyclic boronate structure incorporating a trigonal planar boron atom. Crystals of 5-methyl-5-nitro-2-phenyl-1,3-dioxa-2-boracyclohexane are orthorhombic, a = 17.2358(4), b = 6.5007(2), c = 9.9225(3) Å, Z = 4, space group Pnam. The structure was solved by direct methods and was refined by full-matrix least-squares procedures to R = 0.064 and Rw = 0.070 for 798 reflections with I ≥ 3σ(I). The molecule actually has C1symmetry but, in the solid state, is located at a site of crystallographic Cs symmetry. In order to maintain the apparent mirror symmetry the nitro oxygen atoms are disordered over two mirror-related rotational positions around the C(2)—N bond. The molecule was found to have a monocyclic boronate structure, in agreement with earlier predictions. The six-membered heterocyclic ring has a "semi-planar" conformation. Bond distances and angles are normal.
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Mardenli, Omar R. "The Progeny test of Friesian sires for milk traits by using the contemporary comparison method." Revista Colombiana de Ciencia Animal - RECIA 13, no. 1 (2021): e747. http://dx.doi.org/10.24188/recia.v13.n1.2021.747.
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In this study, the contemporary comparison method (CC) of half-sibs relation was used to estimate the breeding values of Holstein-Friesian sires for 305 -day milk yield (305-DMY) and basic components of milk traits, 409 records of cows that are daughters of ten sires in eight Syrian dairy farms where used. Result of the study showed differences in the estimated breeding values(ccEBVs), where the E Sire achieved the highest value of 305-DMY trait (254.47 kg), while the B Sire achieved the highest value of milk protein percentage (MPP), milk fat percentage (MFP)and milk lactose percentage (MLP) traits (0.822 %, 0.857 %and 1.09% respectively). According to their sires, daughters of E Sire outperformed the counterparts in the 305-DMY (p = 0.001), MPP (p = 0.001) and MFP (p = 0.04) traits (5701.44 kg, 3.55%, and 3.88% respectively). According to source of farm, daughters in Farm 5 achieved the highest value of 305-DMY trait (p=0.04) and daughters in the seventh farm achieved the highest value of MPP trait (p=0.007), the values were 5403.48 kg and 3.54 % respectively. Values of heritability (h2) for the traits of 305-DMY, MPP, MFP and MLP were 0.33,0.54,0.43 and 0.47 respectively. Most of genetic and phenotypic correlations coefficients were approaching to zero except the genetic relation between MLP and MPP and phenotypic relation between MFP and MPP (0.88 and 0.84 respectively).
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Huang, Wentao, Jie Luo, Yifan Li, Da Fei, Xia Qin, and Runsheng Li. "Abstract 6020: Preclinical activity of LM-305 targeting G-protein-coupled receptor class 5 member D (GPRC5D) antibody drug conjugate for the treatment of multiple myeloma." Cancer Research 82, no. 12_Supplement (2022): 6020. http://dx.doi.org/10.1158/1538-7445.am2022-6020.
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Abstract Emerging therapies including chimeric antigen receptor (CAR) T therapy targeting B cell maturation antigen (BCMA) have shown promising clinical outcomes in relapsed and refractory multiple myeloma (RRMM). However, majority of patients eventually develop progressive disease due to heterogeneity in BCMA expression or loss of antigen during treatment. Therefore, new targets are required to overcome the problem of resistance encountered with these agents. The expression of GPRC5D (G-protein-coupled receptor class 5 member D) is high on MM cells and low in normal tissues. Although high levels of GPRC5D and BCMA were found in similar proportions of MM patients, they are independently expressed by MM cells. GPRC5DxCD3 bispecific T-cell-redirecting antibody is currently under clinical investigation. Preliminary results have shown early evidence in efficacy with tolerable safety profile. These findings identified GPRC5D as an ideal therapeutic antibody drug conjugate (ADC) target for the treatment of patients with RRMM. Therefore, the present study was aimed at developing a novel anti-GPRC5D ADC drug LM-305 and evaluating its preliminary efficacy by performing preclinical activity using in vitro and in vivo mouse models. The binding affinity of LM-305 was evaluated by flow cytometry in engineered GPRC5D over-expressing MM tumor cells and endogenous GPRC5D-expressing MM tumor cells. The internalization of LM-305 was assessed with pH-dependent dye in NCI-H929 and MM.1R cell lines. The cytotoxicity of LM-305 was assessed by cell viability assay in MM tumor cell lines. In vivo anti-tumor activity of multiple doses of LM-305 (1mg/kg, 3mg/kg, 10mg/kg) was evaluated in NCI-H929 and MM.1R tumor cell line derived xenograft (CDX) models. In vitro studies revealed that LM-305 binds with high affinity to GPRC5D over-expressing cell lines and GPRC5D endogenously expressing MM cells in a dose-dependent manner. It can be efficiently internalized by GPRC5D expressing cells and further lysosomal lysis was detected by pHrodo dye. LM-305 displayed potent cytotoxicity when co-cultured with MM tumor cells (NCI-H929 and MM.1R) with IC50 values ranging from 0.1 to 0.3 nM. In vivo tumor xenograft models suggested that treatment with LM-305 resulted in dose-dependent inhibition of tumor growth in tumor bearing mice. Additionally, LM-305 exhibited complete response (CR) in the GPRC5D high-expressing MM CDX models at a dose of 3mg/kg. Moreover, LM-305 showed good safety profile in the animal studies. In conclusion, this preclinical data suggested that LM-305 is a novel GPRC5D targeting ADC with best-in-class potential, and therefore it can be a promising therapeutic candidate for the treatment of RRMM patients expressing GPRC5D. Citation Format: Wentao Huang, Jie Luo, Yifan Li, Da Fei, Xia Qin, Runsheng Li. Preclinical activity of LM-305 targeting G-protein-coupled receptor class 5 member D (GPRC5D) antibody drug conjugate for the treatment of multiple myeloma [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr 6020.
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Gomez, Eliana B., Lippincott Isabel, Mary S. Rosendahal, Stephen M. Rothenberg, Steven W. Andrews, and Barb J. Brandhuber. "Loxo-305, a Highly Selective and Non-Covalent Next Generation BTK Inhibitor, Inhibits Diverse BTK C481 Substitution Mutations." Blood 134, Supplement_1 (2019): 4644. http://dx.doi.org/10.1182/blood-2019-126114.
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Introduction: Bruton's Tyrosine Kinase (BTK) is an essential component of normal and malignant B-cell receptor signaling. Covalent BTK inhibitors have transformed the treatment of B-cell malignancies but are limited by off-target toxicity and acquired resistance, leading to eventual treatment discontinuation and disease progression. Emerging evidence suggests that acquired resistance is mediated predominantly by BTK C481 substitution mutations at the covalent BTK inhibitors' binding site. There is significant unmet clinical need for new treatment approaches that overcome acquired resistance and minimize toxicity. LOXO-305 is a highly selective, non-covalent, next generation BTK inhibitor. We previously showed that LOXO-305 potently inhibited both wild-type (WT) BTK and BTK C481S -mediated kinase activity in enzyme and cell-based assays with nanomolar potency, caused regression of BTK-dependent lymphoma mouse xenograft models, and was more than 300-fold selective for BTK over 98% of 370 other kinases tested and showed no significant inhibition of non-kinase off targets at 1 mM (Brandhuber et al. SOHO 2018). In addition, ADME and pharmacokinetic experiments in two preclinical species predicted that LOXO-305 will have high human exposure and sustained BTK C481S target coverage in patients at clinically achievable doses. Here we describe the activity of LOXO-305 against additional BTK C481 substitution mutations, including mutations identified in patients with acquired resistance to covalent BTK inhibitors. We further determine equilibrium-binding affinities for LOXO-305 for diverse mutant BTK enzymes in comparison to other clinically available BTK inhibitors. Methods: To assess cellular BTK inhibitor potency, HEK293T cell lines transiently expressing wild-type BTK and BTK C481 substitution mutations were serum starved and incubated with LOXO-305 overnight. Cells were next incubated with serum and orthovanadate for 5 min and the phosphorylated Y223 BTK was analyzed by immunoblot. Bands were quantified and the IC50 values calculated with GraphPad Prism. The equilibrium-binding affinities for targeted BTK inhibitors to BTK enzyme variants were determined by surface plasmon resonance (SPR) using the Biacore T200. Biotinylated BTK variants were immobilized on a docked streptavidin coated sensor chip. Five concentrations of each inhibitor plus blank controls were analyzed. Association/dissociation rate constants were calculated by global fitting of the data to a 1:1 binding interaction model. Results: While BTK C481S possessed similar levels of basal Y223 autophosphorylation as wild-type BTK in cells, BTK C481T autophosphorylation was reduced by ~50%, C481R by ~90%, and mutants C481F, and C481Y were inactive in HEK293T cells. LOXO-305 inhibited Y223 phosphorylation of all active mutants with similar nanomolar potency. In contrast, autophosphorylation of all BTK C481 mutants were resistant to both Ibrutinib and acalabrutinib. Equilibrium-binding affinities of LOXO-305 for select BTK C481 substitution mutations confirmed LOXO-305's superior potency versus commercially available BTK inhibitors (ibrutinib and acalabrutinib). Conclusions: The next generation, non-covalent, highly selective BTK inhibitor LOXO-305 potently inhibited the cellular activity of BTK C481S, T and R mutations and displayed strong equilibrium binding to WT BTK and several BTK C481 substitution mutations. Together with high selectivity and significant BTK target coverage in vivo, these results indicate that LOXO-305 may overcome acquired resistance to covalent BTK inhibitors in patients without significant off-target toxicity. A phase 1 clinical trial of LOXO-305 is currently underway. Disclosures Gomez: LOXO Oncology Inc.: Employment, Equity Ownership. Isabel:Loxo Oncology: Employment. Rosendahal:Loxo Oncology: Employment. Rothenberg:LOXO Oncology Inc.: Employment. Andrews:Loxo Oncology: Employment. Brandhuber:LOXO Oncology Inc.: Employment, Equity Ownership.
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Zohrabyan, Davit, Samvel Bardakhchyan, Sergo Mkhitaryan, et al. "Breast cancer pathology patterns in Armenia." Journal of Clinical Oncology 38, no. 15_suppl (2020): e12586-e12586. http://dx.doi.org/10.1200/jco.2020.38.15_suppl.e12586.
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e12586 Background: Breast cancer (BC) is the most common malignancy among the women in Armenia (AM). Currently there is a knowledge gap regarding the morphology distribution of the BC in AM. Methods: The data on patients with BC diagnosed in 2015-2016 in the pathology lab “Davidyants Labs” in AM were retrospectively reviewed. Pts with Her2+ results by IHC were excluded from the study, due to unavailability to perform FISH or CISH analyses. Overall 361 pathology reports were evaluated. Results: The median age was 54 years; range [19-82]. Histopathological subtypes were defined for 305 pts, from which lobular carcinoma 57.4% of cases (175/305), ductal carcinoma 26.9% (82/305), mucinous carcinoma 2.6% (8/305), mixed type carcinoma (lobular and ductal) 2.6% (8/305), DCIS 2% (n = 6/305), non specified carcinoma 2% (6/305), medullary carcinoma 1% (n = 3/305) and others 5.6% (17/305). Within the cohort 8.5% (23/270) were grade 1, 65.9% grade 2 (178/270); 25.6% grade 3 (n = 69/270). Vascular or lymphatic invasion was present in 59.5% (50/84) and 64.7% (55/85), respectively. Staging distribution, based on pT pN data for 92 pts who went to primary surgery, was: 0 stage 7.6% (7/92), I stage 22.8% (21/92), II stage 41.3% (38/92), III stage 28.3% (26/92). Staging distribution based on ypT ypN data for 27 pts who went to surgery after neoadjuvant chemo was 0 stage 25.9% (7/27), I stage 18.5% (5/27), II stage 29.6% (8/27), III stage 25.9% (7/27). ER and PR were defined for 244 patients. ER positive 89.8% (219/244) of cases, PR pos. 73% (178/244), ER/PR pos. 72.5% (177/244) cases. Her receptor was defined for 237 patients. Her3+ 16.9% (40/237); Her2+ 12.7% (30/237); Her1+ 38% (90/237); Her0 32.5% (n = 77/237). We could not evaluate Her2+ status by FISH or CISH, so these results were excluded from the analysis. Ki67 was low (≤20) in 42.1% (101/240) of cases and high ( > 20) in 57.9% (139/240). Within the group Luminal A type was 41.4% (84/203); Luminal B 32.5% (66/203); Her positive 19.7% (40/203) and triple negative 6.4% (13/203). p53 and perineural invasion (Pn) was present in 32% (16/50) and 52% (26/50), respectively. Tumor leukocyte infiltration was determined for 16 patients. Leukocyte infiltration was positive in 43.7% (7/16) cases, negative in 25% (4/16) cases, minimal in 31.3% cases (5/16). Conclusions: BC in Armenian women presents with different epidemiological characteristics in comparison with other ethnicities. Lobular type BC is the most frequent type among Armenian women, however, differential diagnosis between lobular/ductal carcinomas was done without IHC (E-Cadherin), which rises the need for further studies on that regard.
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LOLITA, MODANA, I. KOMANG GDE SUKARSA, and MADE SUSILAWATI. "ANALISIS STABILITAS HASIL GENOTIPE JAGUNG MENGGUNAKAN METODE FIXED AMMI." E-Jurnal Matematika 8, no. 1 (2019): 9. http://dx.doi.org/10.24843/mtk.2019.v08.i01.p229.
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Additive Main Effect and Multiplicative Interaction (AMMI) is a method that is used in research to study interaction between genotype and location. The aim of this research is to apply fixed AMMI in examining the production of corn genotype data and to explore yield stability of its based on biplot picture and AMMI Stability Value (ASV). This research uses six corn genotypes, eight trial locations, and three repetitions. The Interaction Principal Component Analysis (IPCA) that are significant to entered in the model based on analysis of variance fixed AMMI are IPCA1, IPCA2, and IPCA3 with total diversity interaction as much as 92,16%. The biplot picture and ASV should the stable genotype in all location are genotype KUI Carotenoid Syn FS. 17-3-2-B-B T01 and genotype CML 305-B-B T01. In addition, corns that are able to adapt only in certain location is: genotype KUI Carotenoid Syn FS. 5-1-5-B-B T01, genotype KUI Carotenoid Syn FS. 25-3-2-B-B T01, genotype KUI Carotenoid Syn FS. 17-3-1-B T01, and genotype CML 130-B-B T01.
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Fabris, Sonia, Giovanna Cutrona, Massimo Gentile, et al. "Incidence of Cytogenetic Abnormalities in Newly Diagnosed Binet Stage A B-CLL and Relationship with Prognostic Biomarkers: Preliminary Results On 305 Patients Included in the Prospective O-CLL1 GISL Study." Blood 114, no. 22 (2009): 2341. http://dx.doi.org/10.1182/blood.v114.22.2341.2341.
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Abstract Abstract 2341 Poster Board II-318 Background. The clinical heterogeneity of chronic lymphocytic leukemia (CLL) requires parameters to stratify patients into prognostic subgroups to adapt treatment ranging from ‘watch and wait’ to allogeneic stem cell transplantation. To this end, several parameters such as lymphocyte doubling time, β-2 microglobulin, CD38 and ZAP-70 expression, immunoglobulin variable heavy chain (IgVH) mutation status and genetic abnormalities, as assessed by fluorescence in situ hybridization (FISH), have been integrated in clinical practice. Aims. In the present study, we investigated by FISH the incidence of the known major cytogenetic alterations (+12 and 13q14, 17p13, 11q23 deletions) in a series of Binet A B-CLL patients included in the prospective O-CLL1 GISL study started in April 2007. Methods. Molecular markers characterization and FISH analyses were performed as previously reported (Cutrona et al. Haematologica, 2008; Fabris et al. GCC, 2008). A cut-off value of 2% was used to distinguish mutated and unmutated patients. CD38 and ZAP-70 were determined by flow-cytometry and a 30% cut-off was used to distinguish between positive or negative cases. Results. Up to date, 326 patients have been enrolled in the trial and FISH data concerning trisomy 12 and 13q14, 17p13, 11q23 deletions were available in 305 patients. At least one abnormality was found in 197 (64%) cases. The most frequent was del(13)(q14) (150/305, 49%), followed by +12 (40/303, 13%) (in one and three cases accompanied by 17p13 and 13q14 deletions, respectively), del(17)(p13) (7/305, 2%) and del(11)(q23) (17/305, 5%). 13q14 deletion was found as a sole abnormality in 134 patients; in the remaining cases, it was combined with +12 (3 pts) and 17p13 (3 pts) or 11q23 (10 pts) deletions. Among patients with 13q14 deletions, 99 were monoallelic, 12 biallelic and 39 showed a combination of the two patterns. Biomarkers data were available in all of the patients: 95/305 (31%) cases had unmutated IgVH genes; ZAP-70 and CD38 were positive in 117/305 (38%) and 72/305 (23%) cases, respectively. Concerning the distribution of cytogenetic aberrations, the unmutated IgVH group included 29/150 (19%) 13q14 deleted cases, 23/40 (57%) cases with trisomy 12 and 4/7 (57%) and 16/17 (94%) with 17p13 and 11q23 deletions, respectively. ZAP-70-positive groups included 43/150 (28%) 13q14 deleted cases, 26/40 (65%) cases showing trisomy 12 and 5/7 (71%) and 12/17 (70%) with 17p13 and 11q23 deletions, respectively. Finally, CD38-positive cases included 18/150 (12%) 13q14 deleted cases, 26/40 (65%) cases carrying trisomy 12 and 5/7 (71%) and 7/17 (41%) with 17p13 and 11q23 deletions, respectively. The percentages of IgVH mutations significantly correlated with cytogenetic alterations; namely, 5.8±0.3 for cases with del(13)(q14), 4.6±0.4 for normal karyotype, 2.6±0.5 in +12, 0.3±0.2 in del(11)(q23), and 1.7±0.9 in del(17)(p13) cases (p for trend <0.0001). A significant correlation was also found for ZAP-70 expression: namely 32±1.8 for cases with del(13)(q14), 38.6±2.2 for normal karyotype, 47.6±3.7 for +12, 55.8±7.0 for del(11)(q22) and 42.4±11.7 for del(17)(p13) (p<0.0001). Similarly, CD38 percentages were (mean value ± sem) 9.3±1.7, 16.9±2.1, 52.9±5.7, 26.8±6.2, 37.0±12.7 for del(13)(q14), normal karyotype, +12, del(11)(q23) and del(17)(p13) alterations, respectively (p for trend <0.0001). Finally, cytogenetic abnormalities were clustered in 3 risk groups [i.e. low del(13)(q14) and normal; intermediate (+12); and high risk del(11)(q23) and del(17)(p13)] and significantly correlated (p<0.0001) with a scoring system in which cases were stratified in 4 different groups according to the absence (group 0) or presence of 1 (group 1), 2 (group 2) or 3 (group 3) biomarkers (Morabito et al., BJH, 2009, voce). Interestingly, 147/154 cases scoring 0, gathered in the low FISH group, whereas 17/22 high FISH risk cases clustered in scoring 2-3. Conclusions. Our preliminary results indicate that in Binet stage A B-CLL patients at diagnosis cytogenetic abnormalities with an expected negative clinical impact are relatively few (7.2%) but significantly associated with prognostic biomarkers which negatively predict the clinical outcome in B-CLL. Disclosures: No relevant conflicts of interest to declare.
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Graulich, Jens, and Dietrich Babel. "Die Kristallstruktur von Bis-[methylammonium]-hexafluorosilikat, (MeNH3)2SiF6 / The Crystal Structure of Bis-[methylammonium]-hexafluorosilicate, (MeNH3)2SiF6." Zeitschrift für Naturforschung B 57, no. 9 (2002): 1003–7. http://dx.doi.org/10.1515/znb-2002-0906.
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The results of a single crystal X-ray structure determination of monoclinic (MeNH3)2SiF6 are reported: a = 962.3(5), b = 964.4(1), c = 966.4(5) pm, " = 100.03(3)°; V = 883.2(7) Å3, Z = 4, space group C2/c; wR2 = 0.0999 based on F02 of 1291 independent reflections (including H refinement without restrictions). The structure is related to that of (NH4)2SiF6, but contains the dumb-bells of the cations well oriented along the greater cell diagonals and fixed by one nearly linear and two bi-furcated hydrogen bonds (N...F: 281 and 293 - 305 pm, resp.). The [SiF6]2- octahedron is nearly undistorted with average bond length Si-F: 167.7 pm (169.9 pm corrected for thermal motion)
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Guru, S. Gadaginamath, R. Puja Shashikant, S. Donawade Dundappa, and R. Kavali Rajesh. "Synthesis and antimicrobial activity of new linearly fused 6-substituted-3,8-diacetyl-4, 7-dimethyl-2H -pyrano[ 6,5-f]indoles, their chemoselective bromnination and synthesis of 3-thiazolylpyranoindoles." Journal of Indian Chemical Society Vol. 81, Oct 2004 (2004): 865–67. https://doi.org/10.5281/zenodo.5832567.
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P.G. Department of Studies' in Chemistry, Karnatak University, Dharwad-580 003, India <em>E-mail</em> : profgmath@yahoo.co.in Indian Institute of Science, Bangalore-560 012, India Korea Advanced Instituted of Science and Technology (KAIST), Taejon 305-701, Korea <em>Manuscript received 1 December 2003, accepted 17 May 2004</em> When 1-substituted-3,6-diacetyl-5-hydroxy-2-methylindoles 1 (a, b) were reacted with ethyl acetoacetate in presence of 2- methylpiperidinc produced new 6-substituted-3,8-diacetyl-4,7-dimethyl-2<em>H</em>-pyrano[6,5-<em>f</em>]indole-2-ones 2(a,b). Then these compounds 2(a,b) were chemoselectively brominated with bromine in chloroform to generate exclusively, 6-substituted-3- bromoacetyl-4,7-dimethyl-8-acetyl-2<em>H</em>-pyrano[6,5-<em>f</em>]indole-2-ones 3(a,b). Compounds 3(a,b) were then refluxed in dry ethanol with thiourea to secure 6-substitutcd 3-(2-aminothiazol-5-yl)-8-acctyl-4,7-dimethyl-2<em>H</em>-pyrano[6,5-<em>f</em>]indole-2-ones 5(a, b). Similarly, <em>o</em>-hydroxyacetophenone 6 was heated with ethyl acetoacetate in presence of 2-methylpiperidine to get 3-acetyl-4- methyl coumarin 7. The structures of all these newly synthesised compounds have been confirmed by spectral and analytical data and the compounds have been screened for antibacterial and antifungal activities.
Conference papers on the topic "305.5/62089090092 b"
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Ando, Masanori, Kodai Toyota, Ryuta Hashidate, and Takashi Onizawa. "Evaluation of the Japanese Fatigue Test Data in Gr.91 for Elevated Temperature Design." In ASME 2021 Pressure Vessels & Piping Conference. American Society of Mechanical Engineers, 2021. http://dx.doi.org/10.1115/pvp2021-60773.
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Abstract The ASME Boiler and Pressure Vessel Code (ASME BPVC) Section III, Division 5, Subsection HB, Subpart B provided only one design fatigue curve for Grade 91 steel (Gr.91) at 540 °C (or 1000 °F) in 2019 and earlier versions. To overcome this disadvantage, The ASME Section III Working Group on Creep-Fatigue and Negligible Creep (WG-CFNC) had taken an action to incorporate the temperature-dependent design fatigue curves for Gr. 91 developed by Japan Society of Mechanical Engineers (JSME) into ASME BPVC Section III Division 5. As a result, the temperature dependent design fatigue curves are provided in the 2021 edition of the ASME BPVC. To clear the features of the best-fit fatigue curve equation developed by the JSME, 305 data stored in the database were analyzed. Details of the database and relationship between the best-fit fatigue curve equation and the data including the statistic values and the values of 95% and 99% lower confidence bound calculated by failure probability assessment were clarified through analysis. In addition to the best-fit fatigue curve equation, an equation for dynamic stress-strain response showing the behavior of Gr.91 steel under cyclic loading of is also provided based on the same database. Moreover, some additional available data of fatigue and creep-fatigue tests obtained in Japan are also provided for considering the creep-fatigue damage evaluation under elevated temperature condition.
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Очередной, А. К. "АНАЛИЗ СТРУКТУР ДВУСТОРОННЕ ОБРАБОТАННыХ ОРУДИй СРЕДНЕГО ПАЛЕОЛИТА ЕВРОПы". У Восточная Европа, Кавказ, Ближний Восток в каменном веке: хронология, источники и культурогенез. Международная конференция. Crossref, 2020. http://dx.doi.org/10.25681/iaras.2020.978-5-94375-305-3.69-71.
Full textAbstract:
Типология среднепалеолитических индустрий, в том или ином виде содержащих бифасиальный компонент, в течение последних двадцати лет претерпевает значительные изменения, заключающиеся в ревизии типологических определений, с одной стороны, сохраняющих традиционный формально-типологический подход, с другой испытывающих значительное влияние т.н. функционального анализа (обзор проблемы, например, здесь: Bosinski, 2006). На уровне конкретного изделия информацию о технологии его изготовления и о его типологических характеристиках может объединять в себе система скалывания, предполагая фактический и жесткий характер связи между типологией и технологией (очередной, 2014). На основании того, что критерий типа образуется из нескольких взаимосвязанных элементов, зависимых друг от друга не иерархически, а линейно, на одном содержательном уровне , а уровни выделения типа могут быть различными (Синицын, 1977, с.164), системы скалывания играют роль таких одноуровневых таксонов и являются одной из технико-типологических единиц (морфем) анализа любых продуктов расщепления. определение системы скалывания в качестве основной единицы для технологического анализа в данном случае двусторонне обработанных форм (например, кайльмессеров или остроконечников), позволяет представить изготовление любого изделия в качестве конструкции, состоящей из серии одинаковых модулей, различающихся только положением на заготовке. Следовательно, основу морфологического/морфографического описания изделия может составить изучение расположения отдельных элементов, изготовленных одной или несколькими системами скалывания (применительно к рассматриваемому материалу это обушки, лезвийные кромки обушков, разные по протяженности и углу наклона, и острия). Прослеживаются степени усложнения итоговых форм (в том числе и редукционные ряды) без перегрузки анализа изготовления каждого конкретного предмета поиском различных chane opratoire (часто неоднозначных и некорректных из-за сложностей в определении последовательности расположения негативов). Фактически при любой типологизации рассматриваемых двусторонне обработанных изделий, изготовленных ударом или комбинациями удара и отжима, следует использовать два основных параметра, регулируемых количеством и расположением систем скалывания: интенсивность утончения (продольного, поперечного и диагонального относительно формы заготовки) и 70 расположение отдельных участков, изготовленных вторичной обработкой (в основном различные виды ретуши, а также парарезцовые сколы/сколы продольного утончения). Выделение систем скалывания на изделиях позволяет следующее: 1) оперировать отдельной, мельчайшей, единицей технологического анализа, которая имеет самостоятельное значение 2) в отличие от Техно-Функционального Анализа (Boeda, 2001) выделяемый элемент не связан напрямую с информацией о его функции, благодаря чему мы можем изучать структуру предмета в качестве основного источника реконструкции конкретной технологии функция изделия должна быть установлена только путем привлечения трасологического анализа 3) выявить основные технологические последовательности, имеющие отношение к тому или иному моменту жизни этого предмета и проводить корректный анализ последовательности изготовления предмета (scar-pattern analysis (kot, 2013) 4) проводить сравнительный анализ структур разных изделий вне зависимости от изменчивости их форм. В последовательности операций при контролируемом расщеплении роль систем скалывания аналогична так называемой рекурсивной вставке (Pastra, Aloimonos, 2012), т. е. такому неизменяемому элементу этого процесса, который задает порядок операций сериями бесконечных самоподобных элементарных последовательностей. Способность к усложнению того или иного процесса посредством рекурсивного воспроизведения его отдельных элементов рассматривается как один из признаков иерархично структурированного сознания (Byrne, Russon, 1998 Казиев, очередной, 2019). Усложненные операционные цепочки, в которых можно проследить такие структуры археологически фиксируются начиная с ашеля (Mahaney, 2014 Stout, 2011 Stout et al., 2014). Список литературы Казиев Э.В., Очередной А.К. Когнитивные структуры в анализе технологии расщепления // Археологическое наследие: материалы и интерпретации. Владикавказ, 2019, с. 420 Очередной А.К. Системы скалывания в анализе изготовления двусторонне обработанных орудий // Проблемы Археологии эпохи Камня . Труды Исторического факультета Санкт-Петербургского Университета, 2014 год, С. 215224 Синицын А.А. К проблеме морфологического анализа каменного инвентаря // Проблемы палеолита Восточной и центральной Европы. Наука , Ленинград, 1977, с. 158166 Степанчук В.Н. Несколько замечаний к методике реконструкции индивидуальной истории каменных изделий со вторичной обработкой // Камяна доба Украiни, Кiев, 2003, С. 3241 Boeda E. Determination des unites techno-fonctionnelles de pices bifacil, es provenant de la couche Acheulenne c3 base du site de Barbas I // les lndusries d outils bifaciaux du Paleolithlque moyen deurope occidentale. Actes de Ia table-roode internationale organisee Caen (Basse-Nonnandie- france) 14 et 71 15 octobre 1999. liege, eRAUl 98, 2001, p. 5175.sinski 2006 Bosinski g. Input determines output. 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