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1

Williams, Jason. "Evaluating Clean Water Act progress drivers for Idaho rivers and streams 2002–2022." PLOS Water 2, no. 8 (2023): e0000112. http://dx.doi.org/10.1371/journal.pwat.0000112.

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In the United States, the Clean Water Act (CWA) is the primary legislation driving surface water quality management. Its goal is to “restore and maintain the chemical, physical, and biological integrity of the Nation’s waters.” Section 305(b) of the CWA requires states to document CWA progress by reporting whether applicable water quality standards are achieved for all state waters every two years. Developing strategies for increasing the proportion of waters achieving standards requires diagnosing factors driving 305(b) data temporal trends. This analysis demonstrates how systematically analy
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2

Kliegel, W., L. Preu, Steven J. Rettig, and James Trotter. "Structural studies of organoboron compounds. XXIV. 5-Methyl-5-nitro-2-phenyl-1,3-dioxa-2-boracyclohexane." Canadian Journal of Chemistry 64, no. 9 (1986): 1855–58. http://dx.doi.org/10.1139/v86-305.

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The title compound was prepared according to the literature in order to determine whether it has a bicyclic cage structure resulting from intramolecular O → B coordination or a monocyclic boronate structure incorporating a trigonal planar boron atom. Crystals of 5-methyl-5-nitro-2-phenyl-1,3-dioxa-2-boracyclohexane are orthorhombic, a = 17.2358(4), b = 6.5007(2), c = 9.9225(3) Å, Z = 4, space group Pnam. The structure was solved by direct methods and was refined by full-matrix least-squares procedures to R = 0.064 and Rw = 0.070 for 798 reflections with I ≥ 3σ(I). The molecule actually has C1s
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3

Mardenli, Omar R. "The Progeny test of Friesian sires for milk traits by using the contemporary comparison method." Revista Colombiana de Ciencia Animal - RECIA 13, no. 1 (2021): e747. http://dx.doi.org/10.24188/recia.v13.n1.2021.747.

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In this study, the contemporary comparison method (CC) of half-sibs relation was used to estimate the breeding values of Holstein-Friesian sires for 305 -day milk yield (305-DMY) and basic components of milk traits, 409 records of cows that are daughters of ten sires in eight Syrian dairy farms where used. Result of the study showed differences in the estimated breeding values(ccEBVs), where the E Sire achieved the highest value of 305-DMY trait (254.47 kg), while the B Sire achieved the highest value of milk protein percentage (MPP), milk fat percentage (MFP)and milk lactose percentage (MLP)
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4

Huang, Wentao, Jie Luo, Yifan Li, Da Fei, Xia Qin, and Runsheng Li. "Abstract 6020: Preclinical activity of LM-305 targeting G-protein-coupled receptor class 5 member D (GPRC5D) antibody drug conjugate for the treatment of multiple myeloma." Cancer Research 82, no. 12_Supplement (2022): 6020. http://dx.doi.org/10.1158/1538-7445.am2022-6020.

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Abstract Emerging therapies including chimeric antigen receptor (CAR) T therapy targeting B cell maturation antigen (BCMA) have shown promising clinical outcomes in relapsed and refractory multiple myeloma (RRMM). However, majority of patients eventually develop progressive disease due to heterogeneity in BCMA expression or loss of antigen during treatment. Therefore, new targets are required to overcome the problem of resistance encountered with these agents. The expression of GPRC5D (G-protein-coupled receptor class 5 member D) is high on MM cells and low in normal tissues. Although high lev
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5

Gomez, Eliana B., Lippincott Isabel, Mary S. Rosendahal, Stephen M. Rothenberg, Steven W. Andrews, and Barb J. Brandhuber. "Loxo-305, a Highly Selective and Non-Covalent Next Generation BTK Inhibitor, Inhibits Diverse BTK C481 Substitution Mutations." Blood 134, Supplement_1 (2019): 4644. http://dx.doi.org/10.1182/blood-2019-126114.

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Introduction: Bruton's Tyrosine Kinase (BTK) is an essential component of normal and malignant B-cell receptor signaling. Covalent BTK inhibitors have transformed the treatment of B-cell malignancies but are limited by off-target toxicity and acquired resistance, leading to eventual treatment discontinuation and disease progression. Emerging evidence suggests that acquired resistance is mediated predominantly by BTK C481 substitution mutations at the covalent BTK inhibitors' binding site. There is significant unmet clinical need for new treatment approaches that overcome acquired resistance an
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6

Zohrabyan, Davit, Samvel Bardakhchyan, Sergo Mkhitaryan, et al. "Breast cancer pathology patterns in Armenia." Journal of Clinical Oncology 38, no. 15_suppl (2020): e12586-e12586. http://dx.doi.org/10.1200/jco.2020.38.15_suppl.e12586.

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e12586 Background: Breast cancer (BC) is the most common malignancy among the women in Armenia (AM). Currently there is a knowledge gap regarding the morphology distribution of the BC in AM. Methods: The data on patients with BC diagnosed in 2015-2016 in the pathology lab “Davidyants Labs” in AM were retrospectively reviewed. Pts with Her2+ results by IHC were excluded from the study, due to unavailability to perform FISH or CISH analyses. Overall 361 pathology reports were evaluated. Results: The median age was 54 years; range [19-82]. Histopathological subtypes were defined for 305 pts, from
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7

LOLITA, MODANA, I. KOMANG GDE SUKARSA, and MADE SUSILAWATI. "ANALISIS STABILITAS HASIL GENOTIPE JAGUNG MENGGUNAKAN METODE FIXED AMMI." E-Jurnal Matematika 8, no. 1 (2019): 9. http://dx.doi.org/10.24843/mtk.2019.v08.i01.p229.

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Additive Main Effect and Multiplicative Interaction (AMMI) is a method that is used in research to study interaction between genotype and location. The aim of this research is to apply fixed AMMI in examining the production of corn genotype data and to explore yield stability of its based on biplot picture and AMMI Stability Value (ASV). This research uses six corn genotypes, eight trial locations, and three repetitions. The Interaction Principal Component Analysis (IPCA) that are significant to entered in the model based on analysis of variance fixed AMMI are IPCA1, IPCA2, and IPCA3 with tota
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8

Fabris, Sonia, Giovanna Cutrona, Massimo Gentile, et al. "Incidence of Cytogenetic Abnormalities in Newly Diagnosed Binet Stage A B-CLL and Relationship with Prognostic Biomarkers: Preliminary Results On 305 Patients Included in the Prospective O-CLL1 GISL Study." Blood 114, no. 22 (2009): 2341. http://dx.doi.org/10.1182/blood.v114.22.2341.2341.

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Abstract Abstract 2341 Poster Board II-318 Background. The clinical heterogeneity of chronic lymphocytic leukemia (CLL) requires parameters to stratify patients into prognostic subgroups to adapt treatment ranging from ‘watch and wait’ to allogeneic stem cell transplantation. To this end, several parameters such as lymphocyte doubling time, β-2 microglobulin, CD38 and ZAP-70 expression, immunoglobulin variable heavy chain (IgVH) mutation status and genetic abnormalities, as assessed by fluorescence in situ hybridization (FISH), have been integrated in clinical practice. Aims. In the present st
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9

Graulich, Jens, and Dietrich Babel. "Die Kristallstruktur von Bis-[methylammonium]-hexafluorosilikat, (MeNH3)2SiF6 / The Crystal Structure of Bis-[methylammonium]-hexafluorosilicate, (MeNH3)2SiF6." Zeitschrift für Naturforschung B 57, no. 9 (2002): 1003–7. http://dx.doi.org/10.1515/znb-2002-0906.

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The results of a single crystal X-ray structure determination of monoclinic (MeNH3)2SiF6 are reported: a = 962.3(5), b = 964.4(1), c = 966.4(5) pm, " = 100.03(3)°; V = 883.2(7) Å3, Z = 4, space group C2/c; wR2 = 0.0999 based on F02 of 1291 independent reflections (including H refinement without restrictions). The structure is related to that of (NH4)2SiF6, but contains the dumb-bells of the cations well oriented along the greater cell diagonals and fixed by one nearly linear and two bi-furcated hydrogen bonds (N...F: 281 and 293 - 305 pm, resp.). The [SiF6]2- octahedron is nearly undistorted w
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10

Guru, S. Gadaginamath, R. Puja Shashikant, S. Donawade Dundappa, and R. Kavali Rajesh. "Synthesis and antimicrobial activity of new linearly fused 6-substituted-3,8-diacetyl-4, 7-dimethyl-2H -pyrano[ 6,5-f]indoles, their chemoselective bromnination and synthesis of 3-thiazolylpyranoindoles." Journal of Indian Chemical Society Vol. 81, Oct 2004 (2004): 865–67. https://doi.org/10.5281/zenodo.5832567.

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P.G. Department of Studies&#39; in Chemistry, Karnatak University, Dharwad-580 003, India <em>E-mail</em> : profgmath@yahoo.co.in Indian Institute of Science, Bangalore-560 012, India Korea Advanced Instituted of Science and Technology (KAIST), Taejon 305-701, Korea <em>Manuscript received 1 December 2003, accepted 17 May 2004</em> When 1-substituted-3,6-diacetyl-5-hydroxy-2-methylindoles 1 (a, b) were reacted with ethyl acetoacetate in presence of 2- methylpiperidinc produced new 6-substituted-3,8-diacetyl-4,7-dimethyl-2<em>H</em>-pyrano[6,5-<em>f</em>]indole-2-ones 2(a,b). Then these compoun
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11

Arora, Sukeshi Patel, Jennifer L. Moseley, Laura LaNiel Tenner, et al. "Phase II study of modulation of sorafenib (SOR)-induced autophagy using hydroxychloroquine (HCQ) in advanced hepatocellular cancer (HCC): Planned interim efficacy and safety analysis." Journal of Clinical Oncology 39, no. 3_suppl (2021): 305. http://dx.doi.org/10.1200/jco.2021.39.3_suppl.305.

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305 Background: SOR is the first systemic therapy approved for advanced HCC, but has shown only modest improvements in survival. Resistance to SOR in pre-clinical models has been attributed to autophagy induction. Autophagy inhibition with HCQ enhanced SOR-induced cell death and apoptosis in early pre-clinic and clinical studies. Data from the phase I study of SOR plus HCQ in advanced solid tumors at showed clinical safety and efficacy. Therefore, we conducted a prospective study to evaluate efficacy of SOR and HCQ in advanced HCC patients (pts) (NCT03037437) and report planned interim analysi
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12

Chan, Yueh-Hsuan, Yu-Tzu Lee, Hung-Wen Chou та ін. "Developing an antibody targeting CεmX of mIgE for the treatment of IgE-mediated diseases (HYP4P.305)". Journal of Immunology 194, № 1_Supplement (2015): 123.4. http://dx.doi.org/10.4049/jimmunol.194.supp.123.4.

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Abstract CεmX (also referred to as M1’) is a discrete domain of 52 a.a. residues, located between the CH4 domain and the C-terminal membrane anchor peptide of the ε heavy chain of membrane-bound IgE (mIgE) on human B lymphocytes. Antibodies that target CεmX are potentially useful in controlling IgE production for treating allergic and other IgE-mediated diseases. Herein we report that an anti-CεmX mAb, 4B12, was shown to be effective in reducing allergen-specific IgE and IL-5 production upon the challenge of the allergen in an asthma model employing CεmX gene knocked-in mice that express mIgE
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13

Podgonykh, S. M., and K. E. Bolotin. "Relationship between the Spontaneous Magnetization, Spontaneous Magnetostriction and Heat Capacity in the Compound Mn5Ge3." Solid State Phenomena 168-169 (December 2010): 153–56. http://dx.doi.org/10.4028/www.scientific.net/ssp.168-169.153.

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Spontaneous magnetization Ms of the ferromagnetic compound Mn5Ge3 with the Curie temperature TC=305 K has been studied in the temperature range from 2 to 400 K. The relationships between the magnetic part of the heat capacity (CMAG), the magnetic part of the volume thermal expansion coefficient (TEC) MAG, and the Ms for the compound Mn5Ge3 have been considered. It has been found that the magnetic part of the heat capacity can be well approximated by the dependence CMAG(T)=a×|dMs2/dT|–b×|dMs4/dT| with a&gt;0 and b&gt;0, and the magnetic part of the TEC, by the dependence  MAG=C1×dMs2/dT+C2×dM
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14

Stillwell, Kyra, Noah Kramer, Bryan Birch, Brandon Reese, Arjun K. Pathak, and Mahmud Khan. "The magnetic and magnetocaloric properties of Al-rich Al0.85+xSi0.15Fe2B2 compounds prepared by drop-casting." AIP Advances 13, no. 2 (2023): 025132. http://dx.doi.org/10.1063/9.0000538.

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Owing to the relative abundance of its constituent elements and large magnetocaloric properties observed near room temperature, the AlFe2B2 system has attracted much attention recently. Here, we have studied the magnetic and magnetocaloric properties of Al0.85+ xSi0.15Fe2B2 ( x = 0.2, 0.4) prepared by drop-casting followed by annealing and acid treatment. The second order ferromagnetic phase transitions were observed near room temperature (∼298–305 K) and peak magnetic entropy changes (−ΔSM) of more than −6 J kg−1 K−1 were observed for a field change of 5 T. The results are discussed in terms
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15

Remaja, I. Nyoman Gede, Made Madiarsa, I. Nyoman Surata, and I. Gede Putu Wirata. "<b>NASKAH AKADEMIK RANCANGAN PERATURAN</b> <b>DAERAH KABUPATEN BULELENG TENTANG</b> <b>PENAMBAHAN PENYERTAAN MODAL DAERAH</b> <b>PADA PERSEROAN TERBATAS BANK</b> <b>PEMBANGUNAN DAERAH BALI</b>." Saraswati: Jurnal Kelitbangan Kabupaten Buleleng 4, no. 1 (2025): 14–32. https://doi.org/10.70986/saraswati.v4i1.58.

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Sampai dengan saat ini penyertaan modal daerah pada PT Bank BPD Bali sudah dilakukan beberapa kali dan sudah terpenuhi pada tahun 2023 sebesar Rp.80.000.000.000 (delapan puluh miliar) berdasarkan Peraturan Daerah Kabupaten Buleleng Nomor 11 Tahun 2021. Tahap selanjutnya memerlukan Penyertaan Modal Daerah tambahan, sehingga dibuat peraturan daerah baru. Karena itu, diperlukan kajian Naskah Akademik Rancangan Peraturan Daerah Kabupaten Buleleng tentang Penambahan Penyertaan Modal Daerah Pada Perseroan Terbatas Bank Pembangunan Daerah Bali.Alasan dan urgensi penambahan penyertaan modal daerah pad
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16

Kaur, I., N. Chawla, A. S. Dhatt, and M. Kaur. "Evaluation of Physico-Chemical Composition in Bulbs of Red, Yellow, and White Onion (Allium Cepa L.) Genotypes of Sub-Tropical India." Acta Alimentaria 49, no. 4 (2020): 483–90. http://dx.doi.org/10.1556/066.2020.49.4.14.

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In this study, thirty onion (Allium cepa L.) genotypes grown in sub-tropical region of India were analysed for different physico-chemical attributes. There were significant differences among genotypes, and the onion genotypes showed a tendency to be classified according to different colours. The cultivars of the same colour exhibited similar tendencies in terms of accumulating most of the analysed components. About 1.78 fold variation in dry matter (%) and 2 fold variation in fresh weight per bulb were recorded among coloured onions. Red genotype D-888-B possessed maximum contents of TS and NRS, wh
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17

Gaina, C., V. Gaina, and M. Sava. "New Poly(4-Dichloro)Maleimides: III. Synthesis and Characterization of Poly[Ether-Ester-Azomethine-(4-Chloro) Maleimides] and Poly(Azomethin Ester-Aspartimides)." High Performance Polymers 13, no. 4 (2001): 269–80. http://dx.doi.org/10.1088/0954-0083/13/4/305.

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New poly[(N-ester-azo)-3-ether-4-chloro)maleimides] and poly(azomethin-ester-aspartimides) were synthesized by the reaction of N-[4-(formylphenoxy carboxylphenyl)]-3-(4-formylphenoxy)-4-chloromaleimide (3 a) or N-[4-formylphenoxycarbonylphenyl)maleimide (3 b) with various diamines. IR and elemental analyses confirmed the structures of the resulting polymers. A series of model compounds were synthesized to facilitate confirmation of the polymer structures. The polymers possess inherent viscosities in the range 0.17–0.42 dl g−1, solubility in aprotic dipolar solvents and 5% weight loss at temper
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18

ARTHUR, P. F., H. HEARNSHAW, R. BARLOW, P. J. WILLIAMSON, P. D. STEPHENSON, and K. DIBLEY. "Evaluation of Hereford and first-cross cows on three pasture systems. III. Milk yield and its influence on calf performance." Journal of Agricultural Science 129, no. 1 (1997): 91–98. http://dx.doi.org/10.1017/s0021859697004553.

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Milk yield was determined by the weigh-suckle-weigh method over 2 years (1983 and 1984 calvings), for a total of 305 purebred Hereford (H×H) and first-cross Brahman×Hereford (B×H), Simmental×Hereford (S×H) and Friesian×Hereford (F×H) cows grazing three pasture systems at Grafton, New South Wales, Australia. The age of the cows ranged from 6 to 11 years. The data were used to evaluate different estimates of milk yield and to examine the effects of milk yield on growth of calves up to weaning.Of all the cow traits studied, average lactation milk yield (average of early, mid and late-lactation mi
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19

Mato, Anthony R., Ian W. Flinn, John M. Pagel, et al. "Results from a First-in-Human, Proof-of-Concept Phase 1 Trial in Pretreated B-Cell Malignancies for Loxo-305, a Next-Generation, Highly Selective, Non-Covalent BTK Inhibitor." Blood 134, Supplement_1 (2019): 501. http://dx.doi.org/10.1182/blood-2019-127509.

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Introduction: Bruton Tyrosine Kinase inhibitors (BTKis) have transformed the treatment of patients with chronic lymphocytic leukemia (CLL) and other B-cell malignancies by inducing durable responses, improving quality of life and prolonging overall survival. Prolonged use of BTKi in the real-world setting is limited by toxicity and acquired resistance. Discontinuation rates for BTKis may be as high as 40% in relapsed/refractory CLL, with BTK C481-mediated resistance evident in many progressing patients. Alternative therapies such as venetoclax are associated with on-target (BCL2) acquired resi
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20

Nourbakhsh, Ali, Shashikant Patil, Prasad Vannemreddy, Alan Ogden, Debi Mukherjee, and Anil Nanda. "The use of bioabsorbable screws to fix Type II odontoid fractures: a biomechanical study." Journal of Neurosurgery: Spine 15, no. 4 (2011): 361–66. http://dx.doi.org/10.3171/2011.4.spine09656.

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Object Anterior screw fixation of the Type II odontoid fracture stabilizes the odontoid without restricting the motion of the cervical spine. The metal screw may limit bone remodeling because of stress shielding (if not placed properly) and limit imaging of the fracture. The use of bioabsorbable screws can overcome such shortcomings of the metal screws. The purpose of this study was to compare the strength of a 5-mm bioabsorbable screw with single 4-mm metal and double 3.5-mm lag screw fixation for Type II fractures of the odontoid process. Methods Three different modalities of anterior screw
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21

Génova, R., J. E. Beckman, and J. Rodríguez Álamo. "Kinematical Structure of the Local Interstellar Medium." International Astronomical Union Colloquium 166 (1997): 195–98. http://dx.doi.org/10.1017/s0252921100070974.

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AbstractObservations of interstellar Na I in the spectra of 93 stars within 315 pc from the Sun show that it lies in a tunnel of gas moving away from Scorpio-Centaurus and is surrounded by gas moving toward the Galactic center.Gas approaches the Sun from Scorpio-Centaurus expanding from (r, l, b)=(160 pc, 313°7, +28°2) with LSR velocity 15.3 km s−1. The radius of this shell is 153 pc.We identify these clouds:D: velocity vector (υd, ld, bd)=(+7.2 km s−1, 305°1, −13°5), above and below the Galactic plane (GP) in the range of Galactic longitudes 357°–55°.C: velocity vector (υc, lc, bc)=(+11.5 km
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22

Jasiurkowska-Delaporte, Małgorzata, Tomasz Rozwadowski, and Ewa Juszyńska-Gałązka. "Kinetics of Non-Isothermal and Isothermal Crystallization in a Liquid Crystal with Highly Ordered Smectic Phase as Reflected by Differential Scanning Calorimetry, Polarized Optical Microscopy and Broadband Dielectric Spectroscopy." Crystals 9, no. 4 (2019): 205. http://dx.doi.org/10.3390/cryst9040205.

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The kinetics of the non-isothermal and isothermal crystallization of the crystalline smectic B phase (soft crystal B, SmBcr) in 4-n-butyloxybenzylidene-4′-n′-octylaniline (BBOA) was studied by a combination of differential scanning calorimetry (DSC), broadband dielectric spectroscopy (BDS) and polarized optical microscopy (POM). On cooling, part of the SmBcr phase undergoes conversion to a crystalline phase and the remainder forms a glassy state; after the glass softens, crystallization is completed during subsequent heating. By analyzing the area of the crystal growing in the texture of SmBcr
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23

Kito, Seiji, and Yuki Ohta. "In vitro fertilization in inbred BALB/c mice II: effects of lactate, osmolarity and calcium on in vitro capacitation." Zygote 16, no. 3 (2008): 259–70. http://dx.doi.org/10.1017/s0967199408004619.

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SummaryTo elucidate requirements for in vitro sperm capacitation in inbred BALB/c mice, osmolarity, calcium and lactate were optimized using modified simplex optimization medium (mKSOM). Modified human tubal fluid (mHTF), a capacitation-supporting medium, was used as a control. In the first series of experiments, the effects of calcium and osmolarity were studied in the presence of lactate. Although preincubation with ≥5 mM CaCl2 improved fertilization after insemination significantly, it was still significantly lower than incubation with mHTF. To obtain fertilization at the equivalent levels
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24

Zaytsev, E. M., M. V. Britsina, M. N. Ozeretskovskaya, N. U. Mertsalova, and I. G. Bazhanova. "Effect of antibodies to agglutinogens 1 and 2, filamentous hemagglutinin and pertussis toxin on formation of Bordetella pertussis biofilms on abiotic substrate." Journal of microbiology, epidemiology and immunobiology 98, no. 3 (2021): 283–89. http://dx.doi.org/10.36233/0372-9311-110.

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Aim. Study of the effect of antibodies to agglutinogens 1 and 2, filamentous hemagglutinin (FHA) and pertussis toxin (PT) on the formation of biofilms by Bordetella pertussis strains on the abiotic substrate.Materials and methods. Vaccine-derived and freshly isolated strains of B. pertussis were used. Cultures of strains grown on a dense nutrient medium were used as an inoculum for obtaining biofilms. The intensity of biofilm formation in round-bottomed polystyrene 96-well plates in the presence of antisera to agglutinogens 1 and 2, antiserum to FHA, and monoclonal antibodies (MСА) to the S1,
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25

Wang, Jian-Rong, Yang-Yuan Li, Dan-Ni Liu та ін. "Codon Optimization Significantly Improves the Expression Level ofα-Amylase Gene fromBacillus licheniformisinPichia pastoris". BioMed Research International 2015 (2015): 1–9. http://dx.doi.org/10.1155/2015/248680.

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α-Amylase as an important industrial enzyme has been widely used in starch processing, detergent, and paper industries. To improve expression efficiency of recombinantα-amylase fromBacillus licheniformis(B. licheniformis), theα-amylase gene fromB. licheniformiswas optimized according to the codon usage ofPichia pastoris(P. pastoris) and expressed inP. pastoris. Totally, the codons encoding 305 amino acids were optimized in which a total of 328 nucleotides were changed and the G+C content was increased from 47.6 to 49.2%. The recombinants were cultured in 96-deep-well microplates and screened b
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26

Szymanska, Iwona, Anna Zbikowska, and Sylwia Onacik-Gür. "New Insight into Food-Grade Emulsions: Candelilla Wax-Based Oleogels as an Internal Phase of Novel Vegan Creams." Foods 13, no. 5 (2024): 729. http://dx.doi.org/10.3390/foods13050729.

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Cream-type emulsions containing candelilla wax-based oleogels (EC) were analyzed for their physicochemical properties compared to palm oil-based creams (EP). The microstructure, rheological behavior, stability, and color of the creams were determined by means of non-invasive and invasive techniques. All the formulations exhibited similar color parameters in CIEL*a*b* space, unimodal-like size distribution of lipid particles, and shear-thinning properties. Oleogel-based formulations were characterized by higher viscosity (consistency index: 172–305 mPa·s, macroscopic viscosity index: 2.19–3.08
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27

Zhang, Feng JIN, JUN ZHI Shu, YI CHUN Xie, et al. "Prognosis of unresectable hepatocellular carcinoma: Comparison of seven staging systems (TNM, Okuda, BCLC, CLIP, CUPI, JIS, CIS) in a Chinese cohort." Journal of Clinical Oncology 34, no. 4_suppl (2016): 305. http://dx.doi.org/10.1200/jco.2016.34.4_suppl.305.

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305 Background: Many liver staging systems that include the tumor stage and the extent of liver function have been developed. However, Prognosis assessment for hepatocellular carcinoma (HCC) remains controversial. In this study, the performances of 7 staging systems were compared in a cohort of patients with HCC who underwent non-surgical treatment. Methods: A total of 196 consecutive patients with HCC who underwent non-surgical treatment seen between January 1, 2004, and December 31, 2007, were included. Performances of TNM sixth edition, Okuda, Barcelona Clinic Liver Cancer (BCLC), Cancer of
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28

Van Wambeke, F., M. Tedetti, S. Duhamel, and R. Sempéré. "Diel variability of heterotrophic bacterial production and UV doses in the South East Pacific." Biogeosciences Discussions 5, no. 1 (2008): 435–62. http://dx.doi.org/10.5194/bgd-5-435-2008.

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Abstract. Diel variability of heterotrophic bacterial production (BP) was investigated in the South East Pacific from October to December 2004 during the BIOSOPE cruise. Three sites differing by their trophic status were studied: Marquesas Islands (MAR; 08° S, 141° W), the centre of the South Pacific Gyre (SPG) (GYR; 26° S, 114° W) and the eastern part of the SPG (EGY; 32° S, 91° W). At the three sites, diel variability of BP ranged from 17 to 40% and from 13 to 22% for volumetric surface (5 m) and integrated (to Ze and Zm) data, respectively. The main feature we observed was at 5 m, an abrupt
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Kőrösi, Zsolt Jenő, Szabolcs Albin Bene, László Bognár, and Ferenc Szabó. "Heritability and Trends in Selected Udder Traits and Their Relation to Milk Production in Holstein-Friesian Cows." Animals 15, no. 9 (2025): 1276. https://doi.org/10.3390/ani15091276.

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This study aimed to evaluate the heritability (h2) estimates of some important udder conformation traits, their relationship to each other and with production, and their phenotypic and genetic trends over a 10-year period in relatively high-yielding Holstein-Friesian cows. A total of 15,032 cows from six herds in Hungary were tested for milk (MY), butterfat (FY), and protein (PY) production yields over 305 days in first lactation. In addition, their udder conformation was scored for udder attachment (FU), rear udder height (RUH), central ligament (CL), udder depth (UD), front teat placement (F
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Chapagai, M. K., Wan Rosli W.I., T. Karilla, and S. Pinkaew. "Variety difference of physicochemical and cooking properties of selected brown rice from Thailand and Malaysia." Food Research 4, no. 3 (2019): 630–35. http://dx.doi.org/10.26656/fr.2017.4(3).305.

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Rice is a major staple food in Thailand and Malaysia. Although brown rice is a highly healthy substitute, preference is very low due to its texture and cooking quality. However, there are some brown rice varieties such as Sungyod (SY), Chiang (CH), Lepnok (LP) from Thailand and long grain specialty 1(LS1) and long grain specialty 2 (LS2) from Malaysian peninsula are commonly consumed in such areas. This study aimed to investigate the physicochemical and the cooking properties of these brown rice to understand the properties for better utilization. Therefore, Rapid visvo analyser (RVA), soaking
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CHOUDHARY, DEEKSHA. "Long term effect of STCR-based targeted yield application of fertilizers on productivity, profitability and nutrient uptake by wheat (Triticum aestivum L.) in an acid Alfisol." Annals of Plant and Soil Research 24, no. 3 (2022): 373–77. http://dx.doi.org/10.47815/apsr.2022.10178.

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The present investigation was conducted during therabi season of 2017-18 at the research farm of CSK HPKV, Palampur (Himachal Pradesh). The effect of target yield based fertilizer application on productivity, profitability, and nutrient uptake by wheat were evaluated in a randomized block design with eight treatments. The results revealed that the continuous cropping for 10 years along with STCR based fertilizer application in target yield 35 q ha-1 + 5 t FYM ha-1 recorded the highest grain yield (34.9 q ha-1 ) followed by target 35 q ha-1 (31.6 q ha-1 ).The highest protein content (12.6 %) an
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CHOUDHARY, DEEKSHA. "Long term effect of STCR-based targeted yield application of fertilizers on productivity, profitability and nutrient uptake by wheat (Triticum aestivum L.) in an acid Alfisol." Annals of Plant and Soil Research 24, no. 3 (2022): 373–77. http://dx.doi.org/10.47815/apsr.2021.10178.

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The present investigation was conducted during therabi season of 2017-18 at the research farm of CSK HPKV, Palampur (Himachal Pradesh). The effect of target yield based fertilizer application on productivity, profitability, and nutrient uptake by wheat were evaluated in a randomized block design with eight treatments. The results revealed that the continuous cropping for 10 years along with STCR based fertilizer application in target yield 35 q ha-1 + 5 t FYM ha-1 recorded the highest grain yield (34.9 q ha-1) followed by target 35 q ha-1 (31.6 q ha-1).The highest protein content (12.6 %) and
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33

Echemendia, R., K. E. Riegler, W. Meeuwisse, et al. "A - 26 Re-establishing and Refining Baseline Neuropsychological Test Data Among Professional Hockey Players Using Regression-Based Prediction Models." Archives of Clinical Neuropsychology 40, Supplement_1 (2025): i26. https://doi.org/10.1093/arclin/acaf058.26.

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Abstract Purpose Create contemporary culturally relevant baseline reference values for use in evaluating concussed NHL athletes using traditional and regression-based models that are co-normed with estimates of premorbid functioning and English language proficiency. Method Across two seasons five (5) players from each NHL Club (32 clubs) each season were selected at random (with oversampling of ESL athletes) and underwent testing with the NHL Neuropsychological Testing Battery: English Proficiency Questionnaire (ESL only), ToPF, HVLT-R, BVMT-R, SDMT, TMT A&amp;B, COWAT, and Digit Span Forward/
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34

Reis, A. M., M. Jankowski, S. Mukaddam-Daher, J. Tremblay, T.-V. Dam, and J. Gutkowska. "Regulation of the natriuretic peptide system in rat uterus during the estrous cycle." Journal of Endocrinology 153, no. 3 (1997): 345–55. http://dx.doi.org/10.1677/joe.0.1530345.

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Abstract Uterine natriuretic peptides may be involved in the alterations that occur in the uterus during the estrous cycle through its role in hydromineral balance. The following studies were performed to determine whether uterine natriuretic peptides and receptors follow a cyclic pattern during the estrous cycle. The results obtained show that atrial natriuretic peptide (ANP) content in rat uterine tissue was low in proestrus (8·5 ± 2·6 pg/g) and significantly increased (P&lt;0·001) in estrus (71·5 ± 16·6 pg/g), metestrus (82·6 ± 19·7 pg/g) and diestrus (91·0 ± 19·4 pg/g), whereas plasma ANP
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35

Bokemeyer, C., I. Bondarenko, A. Makhson, et al. "Cetuximab plus 5-FU/FA/oxaliplatin (FOLFOX-4) versus FOLFOX-4 in the first-line treatment of metastatic colorectal cancer (mCRC): OPUS, a randomized phase II study." Journal of Clinical Oncology 25, no. 18_suppl (2007): 4035. http://dx.doi.org/10.1200/jco.2007.25.18_suppl.4035.

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4035 Background: FOLFOX-4 is a standard first-line treatment for patients (pts) with mCRC. The IgG1 monoclonal antibody cetuximab has proven activity in combination with cytotoxic chemotherapy. Excellent response rates (RRs) have been reported with first-line cetuximab and FOLFOX-4. This randomized, controlled study was conducted to compare RRs of FOLFOX-4 + cetuximab vs FOLFOX-4. Methods: Pts with previously untreated epidermal growth factor receptor (EGFR)-expressing mCRC not resectable with curative intent were eligible. They were randomized 1:1, stratified by ECOG performance status (PS) (
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Ramaswamy, Anant, Prabhat Ghanshyam Bhargava, Biswajit Dubashi, et al. "A two-arm randomized open-label prospective design superiority phase III clinical trial to compare the efficacy of docetaxel-oxaliplatin-capecitabine/5 fluorouracil (DOC/F) followed by docetaxel versus CAPOX/mFOLFOX-7 in advanced gastric cancers (DOC-GC study)." Journal of Clinical Oncology 42, no. 3_suppl (2024): LBA248. http://dx.doi.org/10.1200/jco.2024.42.3_suppl.lba248.

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LBA248 Background: The choice of optimal chemotherapy in advanced (unresectable/metastatic) gastroesophageal junction and gastric (GEJ/G) adenocarcinomas remains undecided with regard to the addition of docetaxel to a FOLFOX/CAPOX backbone in improving outcomes with equipoise with regard to the optimal duration of chemotherapy as well. Methods: The DOC GC study is a multicentric open-label, randomized controlled phase III trial, in adults ≥18 years with advanced GEJ/G adenocarcinoma and adequate end-organ function. Patients were randomized 1:1 to one of two arms: Arm A - modified CAPOX (3 week
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Rodriguez, Nicolette J., C. Sloane Furniss, Matthew B. Yurgelun, et al. "Abstract A029: A randomized study of two Strategies of remote Genetic Education, Risk Assessment, and Testing (GENERATE) for family members of patients with pancreatic cancer." Cancer Research 82, no. 22_Supplement (2022): A029. http://dx.doi.org/10.1158/1538-7445.panca22-a029.

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Abstract Background: Uptake of genetic testing for cancer susceptibility in family members of cancer patients is suboptimal. The GENetic Education, Risk Assessment, and TEsting (GENERATE) study evaluated two strategies of remote genetic education and testing in relatives of pancreatic ductal adenocarcinoma (PDAC) patients. Methods: Eligible participants had: a first-degree relative with PDAC or had a known pathogenic germline variant (PGV) in one of thirteen PDAC predisposition genes (APC, ATM, BRCA1, BRCA2, CDKN2A, EPCAM, MLH1, MSH2, MSH6, PALB2, PMS2, STK11, or TP53) and a first- or second-d
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COULON, J. B., P. D’HOUR, M. PETIT, E. ALBARET, and M. JAWOREK. "Niveau et répartition des apports de concentré hivernaux chez la vache laitière. Résultats sur primipares." INRAE Productions Animales 3, no. 5 (1990): 319–28. http://dx.doi.org/10.20870/productions-animales.1990.3.5.4390.

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Cent dix neuf vaches laitières en première lactation ayant vêlé en moyenne le 6 décembre ont été utilisées au cours d’un essai conduit 3 années consécutives. Au cours de l’hiver, tous les animaux recevaient une ration de base composée d’ensilage d’herbe (à volonté) et de foin (4 kg/j). Chaque année 5 lots ont été constitues : 3 niveaux d’apport de concentré au cours de la période hivernale (haut H, moyen M et bas B), et pour chacun des 2 niveaux inférieurs, 2 modes de répartition du concentré (classique (C) ou uniforme (U)), ont été comparés. Au pâturage toutes les vaches ont été conduites ens
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39

Rawofi, Lida, Melissa Edwards, S. Krithika, et al. "Genome-wide association study of pigmentary traits (skin and iris color) in individuals of East Asian ancestry." PeerJ 5 (November 2, 2017): e3951. http://dx.doi.org/10.7717/peerj.3951.

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Background Currently, there is limited knowledge about the genetics underlying pigmentary traits in East Asian populations. Here, we report the results of the first genome-wide association study of pigmentary traits (skin and iris color) in individuals of East Asian ancestry. Methods We obtained quantitative skin pigmentation measures (M-index) in the inner upper arm of the participants using a portable reflectometer (N = 305). Quantitative measures of iris color (expressed as L*, a* and b* CIELab coordinates) were extracted from high-resolution iris pictures (N = 342). We also measured the co
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Diah, Chiquita Prahasanti, Retno Puji Rahayu, and Vani Rachmad Wijayanto. "Characterization of ultraviolet B light emitting diodes (UVB LED) irradiation device for Wistar rats as an experimental animal model." Bali Medical Journal 12, no. 3 (2023): 2516–20. http://dx.doi.org/10.15562/bmj.v12i3.4639.

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Link of Video Abstract: https://youtu.be/-l5AY96hUI8 Background: Light emitting diodes (LED) lamps are used widely in daily because of their many benefits, including their low cost, extended lifespan, low energy consumption, and low environmental impact. The use of LEDs, especially ultraviolet B LED (UVB LEDs) is quite extensive and has been developed for the treatment of skin diseases, irradiating pet reptiles, and conducting research on experimental animals. The use of light for therapy must be done carefully so that unwanted side effects do not occur because light also harms tissue. The pur
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Savage, Kerry J., Mukesh Chhanabhai, Nicholas Voss, Shenkier Tamara, Randy D. Gascoyne, and Joseph M. Connors. "Survival of Limited Stage Peripheral T-Cell Lymphoma Is Similar To Diffuse Large B-Cell Lymphoma." Blood 106, no. 11 (2005): 2817. http://dx.doi.org/10.1182/blood.v106.11.2817.2817.

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Abstract Background: Peripheral T-cell lymphomas (PTCL) represent a heterogeneous group of diseases with an overall poor prognosis. Little information is available regarding the outcome of PTCL patients who present with limited stage disease. We sought to determine the outcome of PTCL patients presenting with limited disease in comparison with a cohort of patients with limited stage diffuse large B-cell lymphoma (DLBCL). Methods: In a retrospective analysis we identified all patients with limited stage (non-bulky (&lt;10cm) stage I/II disease no symptoms) PTCL diagnosed at the British Columbia
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Waanders, Esmee, Frank N. van Leeuwen, Eugene Verwiel, et al. "Pediatric Precursor-B ALL with BTG1 Deletions Show a Distinct Genomic Profile." Blood 114, no. 22 (2009): 3244. http://dx.doi.org/10.1182/blood.v114.22.3244.3244.

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Abstract Abstract 3244 Poster Board III-181 Recent genome-wide profiling studies have revealed that childhood acute lymphoblastic leukemia (ALL) is characterized by recurrent microdeletions, including the cell cycle regulator CDKN2A, the B-cell differentiation genes PAX5, EBF1 and IKZF1 (Ikaros) and the anti-proliferative gene B-cell translocation gene 1 (BTG1). In a previous study, we have shown that BTG1 is an important determinant of glucocorticoid sensitivity (Van Galen et al. Blood/ ASH Annual Meeting Abstracts, 2008). In the present study we have characterized these cases in more detail
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Amiri, A., A. I. Zuniga, and N. A. Peres. "Potential Impact of Populations Drift on Botrytis Occurrence and Resistance to Multi- and Single-Site Fungicides in Florida Southern Highbush Blueberry Fields." Plant Disease 102, no. 11 (2018): 2142–48. http://dx.doi.org/10.1094/pdis-11-17-1810-re.

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Incidence of blossom blight and Botrytis fruit rot (BFR), caused by Botrytis cinerea, on two southern highbush blueberry cultivars was evaluated in several blueberry fields grown in the vicinity (BB-Str(+)) or not (BB-Str(−)) of strawberry fields in central Florida. Blossom blight and BFR incidence were higher in BB-Str(+) fields in 2014 and significantly higher in 2015 compared to BB-Str(−) fields. In total, 613 B. cinerea isolates (i.e., 181 and 432 isolates from BB-Str(−) and BB-Str(+) fields, respectively) were collected. The isolates were evaluated for sensitivity to eight single-site and
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Ajčević, Miloš, Alex Buoite Stella, Giovanni Furlanis, et al. "A Novel Non-Invasive Thermometer for Continuous Core Body Temperature: Comparison with Tympanic Temperature in an Acute Stroke Clinical Setting." Sensors 22, no. 13 (2022): 4760. http://dx.doi.org/10.3390/s22134760.

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There is a growing research interest in wireless non-invasive solutions for core temperature estimation and their application in clinical settings. This study aimed to investigate the use of a novel wireless non-invasive heat flux-based thermometer in acute stroke patients admitted to a stroke unit and compare the measurements with the currently used infrared (IR) tympanic temperature readings. The study encompassed 30 acute ischemic stroke patients who underwent continuous measurement (Tcore) with the novel wearable non-invasive CORE device. Paired measurements of Tcore and tympanic temperatu
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Spicer, D. B., and G. E. Sonenshein. "An antisense promoter of the murine c-myc gene is localized within intron 2." Molecular and Cellular Biology 12, no. 3 (1992): 1324–29. http://dx.doi.org/10.1128/mcb.12.3.1324-1329.1992.

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Previously we have demonstrated the existence of stable transcripts from the noncoding strand of a rearranged c-myc gene in murine plasmacytomas in which the oncogene has translocated to an immunoglobulin constant-region gene element (M. Dean, R. B. Kent, and G. E. Sonenshein, Nature [London] 305:443-446, 1983). The resulting RNAs are chimeric, containing c-myc antisense and immunoglobulin sense sequences. A normal unrearranged murine c-myc gene is transcribed in the antisense orientation throughout much of the gene; however, stable transcripts have not been detected. In this study, using Nort
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Hidayat, Wahyu, Ema Utami, and Andi Sunyoto. "Selection of the Best K-Gram Value on Modified Rabin-Karp Algorithm." IJCCS (Indonesian Journal of Computing and Cybernetics Systems) 16, no. 1 (2022): 11. http://dx.doi.org/10.22146/ijccs.63686.

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The Rabin-Karp algorithm is used to detect similarity using hashing techniques, from related studies modifications have been made in the hashing process but in previous studies have not been conducted research for the best k value in the K-Gram process. At the stage of stemming the Nazief &amp; Adriani algorithm is used to transform the words into basic words. The researcher uses several variations of K-Gram values to determine the best K-Gram values. The analysis was performed using Ukara Enhanced public data obtained from the Kaggle with a total of 12215 data. The student essay answers data
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Winiczenko, Radosław, Andrzej Sibicki, Paweł Skoczylas, and Jędrzej Trajer. "A genetic algorithm modelling of temperature distributions in the AZ31B magnesium alloys with 7075 aluminium alloy friction welded joints." E3S Web of Conferences 132 (2019): 01029. http://dx.doi.org/10.1051/e3sconf/201913201029.

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This paper presents a genetic algorithm modelling of temperature distribution during heating and cooling of AZ31B magnesium alloys with 7075 aluminium alloy friction welded joints. The temperature distributions estimated in the joints using K-type thermocouples with the accuracy of ±⚟0.1°C. The thermocouples were installed in 1.2 mm holes at the periphery joint - 5, 10, and 15 mm from the weld interface. Temperature reading was performed with a digital thermometer with the requisition frequency of 1000Hz during friction welding. Maximum temperature measurements in the half-radius of the analys
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Spicer, D. B., and G. E. Sonenshein. "An antisense promoter of the murine c-myc gene is localized within intron 2." Molecular and Cellular Biology 12, no. 3 (1992): 1324–29. http://dx.doi.org/10.1128/mcb.12.3.1324.

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Previously we have demonstrated the existence of stable transcripts from the noncoding strand of a rearranged c-myc gene in murine plasmacytomas in which the oncogene has translocated to an immunoglobulin constant-region gene element (M. Dean, R. B. Kent, and G. E. Sonenshein, Nature [London] 305:443-446, 1983). The resulting RNAs are chimeric, containing c-myc antisense and immunoglobulin sense sequences. A normal unrearranged murine c-myc gene is transcribed in the antisense orientation throughout much of the gene; however, stable transcripts have not been detected. In this study, using Nort
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49

Ramalingam, Poongodi, Sumathi M, Sundareshwari R, et al. "A Study to Assess the Level of Softskill Practices Among Nursing Students in Selected Colleges." International Journal of Experimental Research and Review 42 (August 30, 2024): 210–16. http://dx.doi.org/10.52756/ijerr.2024.v42.018.

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Soft skills are the habits and traits that determine how a person operates in the workplace like communicating with others. Students are in a position to prove themselves in different aspects, which is not possible by technology. The soft skills identified as important in the workplace include communication, teamwork, motivation, problem-solving, enthusiasm, and trust. A quantitative, descriptive cross-sectional approach was used to assess the knowledge and practice of soft skills among nursing students at selected nursing colleges in Chennai. The target population was B. Sc Nursing Basic stud
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Pracella, Danae, Serena Bonin, Renzo Barbazza, et al. "Are Breast Cancer Molecular Classes Predictive of Survival in Patients with Long Follow-Up?" Disease Markers 35 (2013): 595–605. http://dx.doi.org/10.1155/2013/347073.

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In this study we investigate the clinical outcomes of 305 breast cancer (BC) patients, aged 55 years or younger, with long follow-up and according to intrinsic subtypes. The cohort included 151 lymph node negative (LN−) and 154 lymph node positive (LN+) patients. Luminal A tumors were mainly LN−, well differentiated, and of stage I; among them AR was an indicator of good prognosis. Luminal B and HER2 positive nonluminal cancers showed higher tumor grade and nodal metastases as well as higher proliferation status and stage. Among luminal tumors, those PR positive and vimentin negative showed a
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