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1

Ayintap, Emre, Uğurcan Keskin, Fariz Sadigov, et al. "The Injection of Air/Oxygen Bubble into the Anterior Chamber of Rabbits as a Treatment for Hyphema in Patients with Sickle Cell Disease." Journal of Ophthalmology 2014 (2014): 1–4. http://dx.doi.org/10.1155/2014/696302.

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Purpose.To investigate the changes of partial oxygen pressure (PaO2) in aqueous humour after injecting air or oxygen bubble into the anterior chamber in sickle cell hyphema.Methods.Blood samples were taken from the same patient with sickle cell disease. Thirty-two rabbits were divided into 4 groups. In group 1 (n=8), there was no injection. Only blood injection constituted group 2 (n=8), both blood and air bubble injection constituted group 3 (n=8), and both blood and oxygen bubble injection constituted group 4 (n=8).Results.The PaO2in the aqueous humour after 10 hours from the injections was
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2

Nurhikmah, Wilda, Erni Rustiani, and Dania Triska Puspita. "PENGEMBANGAN SEDIAAN TABLET ESTROGENIK DARI EKSTRAK RUMPUT KEBAR (Biophytum petersianum) MENGGUNAKAN VARIASI KONSENTRASI PENGIKAT PVP K-30." Jurnal Ilmiah Manuntung 9, no. 2 (2023): 111–19. http://dx.doi.org/10.51352/jim.v9i2.661.

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Kebar grass (Biophytum petersianum Klotzsch) contains steroid, saponins, flavonoids, alkaloids, and triterpenoids. The use of Kebar grass extract can increase the development of follicles because it contains saponins which are the basic ingredients for the synthesis of steroid hormones and can improve the performance of reproductive system. This study aims to determine the quality the tablets made from Kebar grass extract with varying concentrations of PVP K-30 binder. Tablets were made in 3 formulas with varying concentrations of PVP K-30 as a binder, namely 2% (F1), 3% (F2), and 4% (F3). Met
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Albor-Avendaño, María Rosalía, Francisco Rojo-Calleja, Marte Lorenzana-Jiménez, and María Teresa de Jesús Arredondo-Garza. "Contaminación ambiental de quirófanos y personal quirúrgico por sevoflurano." Revista de Farmacología 2, no. 2 (2023): 46–57. http://dx.doi.org/10.58713/rf.v2i2.3.

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Antecedentes: El personal quirúrgico tiene alto riesgo de desarrollar enfermedad profesional por exposición crónica a gases anestésicos.Objetivo: Conocer las concentraciones ambientales en quirófanos y sanguíneas de sevoflurano en personal quirúrgico del Hospital General La Perla Nezahualcóyotl del ISEM.Metodología: Se hicieron dos grupos: grupo A con 40 individuos expuesto a sevoflurano y B con 8 controles. Se tomaron muestras ambientales de quirófanos antes y después de la realización de 10 anestesias generales balanceadas con sevoflurano y sanguíneas en el personal quirúrgico previas y post
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4

Zhang, Jing, Shouguo Huang, Lini Quan, et al. "Determination of Potential Therapeutic Targets and Prognostic Markers of Ovarian Cancer by Bioinformatics Analysis." BioMed Research International 2021 (March 19, 2021): 1–13. http://dx.doi.org/10.1155/2021/8883800.

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This study is to study the expression of CXCRs in ovarian cancer tissues and their value in prognosis. The expressions of CXCR1-CXCR7 mRNA between ovarian tumor tissues and normal tissues and in different pathological types of ovarian tumor tissues were compared by ONCOMINE online tool. The relationship between the expression of CXCRs and clinical pathological staging was studied by GEPIA. Kaplan-Meier plotter online tool was used to analyze prognosis. Finally, GO and KEGG analyses and protein interaction network analysis were performed for CXCRs by the DAVID software to predict their function
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5

Rahman, Md Hasanur. "A STUDY ON DETERMINING LAND USE/LAND COVER CHANGES IN DHAKA OVER THE LAST 20 YEARS AND OBSERVING THE IMPACT OF POPULATION GROWTH ON LAND USE/LAND COVER USING REMOTE SENSING." Malaysian Journal of Civil Engineering 34, no. 2 (2022): 1–9. http://dx.doi.org/10.11113/mjce.v34.17812.

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Land use is an important factor in understanding how human activities change the environment. Changes need to be monitored and identified in order to maintain a sustainable and conducive environment in any city. Dhaka, the capital of Bangladesh, is one of the most densely populated megacities in the world with an area of ​​306.4 km2. This study has highlighted how land use has changed as a result of rapid urbanization in Dhaka city in the last 20 years and the relationship of population with these land uses. Land use has been reviewed during the previous 20 years by creating a map of LULC usin
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6

Vats, Rajeev. "Infl uence of selenium deficiency on neural tube defects." Asian Journal of Medical Sciences 6, no. 2 (2014): 62–65. http://dx.doi.org/10.3126/ajms.v6i2.11151.

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Objective: As for the role of selenium on human fetal development, a little data is available in literature. The purpose of this manuscript was to study the influence of selenium on neural tube defects. This study will be helpful in planning strategies for prevention of neural tube defects.Methodology: After collection of the venous blood the same was immediately centrifuged and after immediate centrifugation, the clear serum was transferred to deionized plastic vials, stored and frozen at –20º C until determination of the analysis was carried out. The selenium levels as ng/ml were determined
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7

Heiskanen, Mette, Olli Jääskeläinen, Eppu Manninen, et al. "Plasma Neurofilament Light Chain (NF-L) Is a Prognostic Biomarker for Cortical Damage Evolution but Not for Cognitive Impairment or Epileptogenesis Following Experimental TBI." International Journal of Molecular Sciences 23, no. 23 (2022): 15208. http://dx.doi.org/10.3390/ijms232315208.

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Plasma neurofilament light chain (NF-L) levels were assessed as a diagnostic biomarker for traumatic brain injury (TBI) and as a prognostic biomarker for somatomotor recovery, cognitive decline, and epileptogenesis. Rats with severe TBI induced by lateral fluid-percussion injury (n = 26, 13 with and 13 without epilepsy) or sham-operation (n = 8) were studied. During a 6-month follow-up, rats underwent magnetic resonance imaging (MRI) (day (D) 2, D7, and D21), composite neuroscore (D2, D6, and D14), Morris-water maze (D35–D39), and a 1-month-long video-electroencephalogram to detect unprovoked
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8

Zanatta, E., R. Depascale, A. Gamba, et al. "POS1217 CCL-18 AS A BIOMARKER OF INTERSTITIAL LUNG DISEASE (ILD) AND PROGRESSIVE FIBROSING ILD IN PATIENTS WITH IDIOPATHIC INFLAMMATORY MYOPATHIES." Annals of the Rheumatic Diseases 82, Suppl 1 (2023): 943–44. http://dx.doi.org/10.1136/annrheumdis-2023-eular.6184.

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BackgroundInterstitial lung disease (ILD) is the most frequent organ involvement in patients with idiopathic inflammatory myopathies (IIMs). Some patients with connective tissue diseases including IIMs may develop a progressive fibrosing (PF-)ILD [1]. The chemokine CCL18 is constitutively expressed by dendritic cells and macrophages in lung tissues and may induce collagen synthesis in lung fibroblasts. Circulating CCL18 correlated with fibrosis severity in idiopathic pulmonary fibrosis and it predicts ILD progression in patients with systemic sclerosis (SSc) [2]. OX40 ligand (OX40L) is a glyco
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9

Cunningham, Bryan W., Nianbin Hu, Candace M. Zorn, and Paul C. McAfee. "Comparative fixation methods of cervical disc arthroplasty versus conventional methods of anterior cervical arthrodesis: serration, teeth, keels, or screws?" Journal of Neurosurgery: Spine 12, no. 2 (2010): 214–20. http://dx.doi.org/10.3171/2009.9.spine08952.

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Object Using a synthetic vertebral model, the authors quantified the comparative fixation strengths and failure mechanisms of 6 cervical disc arthroplasty devices versus 2 conventional methods of cervical arthrodesis, highlighting biomechanical advantages of prosthetic endplate fixation properties. Methods Eight cervical implant configurations were evaluated in the current investigation: 1) PCM Low Profile; 2) PCM V-Teeth; 3) PCM Modular Flange; 4) PCM Fixed Flange; 5) Prestige LP; 6) Kineflex/C disc; 7) anterior cervical plate + interbody cage; and 8) tricortical iliac crest. All PCM treatmen
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10

Terpos, Evangelos, Dimitrios Christoulas, Efstathios Kastritis, et al. "Tubular Damage Is Present In Patients With MGUS and Asymptomatic Multiple Myeloma Even In The Absence Of Impaired Estimated Glomerular Filtration Rate; Alterations Of Neutrophil Gelatinase-Associated Lipocalin and Cystatin-C In Myeloma Patients Post IMiD- and Bortezomib-Based Regimens." Blood 122, no. 21 (2013): 3091. http://dx.doi.org/10.1182/blood.v122.21.3091.3091.

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Abstract Neutrophil gelatinase-associated lipocalin (NGAL) is a 25 kDa protein, which is produced by the injured tubule epithelium. In contrast to serum creatinine (sCr), NGAL is specifically induced in the damaged nephron and then released into blood and urine; thus it is considered as an early marker of renal tubular injury. Our group has recently shown that urinary and serum NGAL were elevated in the vast majority (90% and 70%, respectively) of newly diagnosed patients with multiple myeloma (MM), while serum cystatin-C (CysC), an accurate marker of GFR, was elevated in 70% of them. However,
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11

Leonard, Jessica T., Jeffrey W. Tyner, Joelle Rowley, Marc M. Loriaux, Brian J. Druker, and Bill H. Chang. "Venetoclax Resistant Philadelphia Chromosome Positive Acute Lymphoblastic Leukemia Cells Are Also Resistant to ABL Inhibitors, Which Can be Overcome By Targeting the PI3K/AKT/ mTOR Pathway." Blood 128, no. 22 (2016): 1583. http://dx.doi.org/10.1182/blood.v128.22.1583.1583.

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Abstract Introduction: Venetoclax is a BH3-mimetic shown to specifically inhibit BCL-2 and has activity in hematologic malignancies addicted to BCL-2, including Ph+ ALL. However, when used as a single agent resistance develops through upregulation as well as post-translational modifications of MCL-1 from a variety of different pathways. It remains unknown what effects if any BCL-2 resistance will have on ABL kinase inhibition. In these studies, we investigated whether acquired resistance to venetoclax affected kinase sensitivity in a pre clinical model of Ph+ ALL. Methods: A venetoclax resista
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12

Gambacorti-Passerini, Carlo, Tim H. Brümmendorf, Elisabetta Abruzzese, et al. "Efficacy and Safety of Bosutinib in Previously Treated Patients with Chronic Myeloid Leukemia: Final Results from the Byond Trial." Blood 138, Supplement 1 (2021): 1475. http://dx.doi.org/10.1182/blood-2021-150352.

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Abstract Introduction: Bosutinib is approved for patients with Philadelphia chromosome-positive (Ph+) chronic myeloid leukemia (CML) resistant/intolerant to prior therapy and patients with newly diagnosed Ph+ chronic phase (CP) CML. The phase 4 BYOND trial (NCT02228382) further evaluated the efficacy and safety of bosutinib in patients with previously treated CML. We report the final results from BYOND. Methods: Patients with CML resistant/intolerant to previous tyrosine kinase inhibitor therapy received bosutinib 500 mg once daily. This final analysis was based on a November 23, 2020 database
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13

Şahin, Ahmet Bilgehan, Erdem Cubukcu, Birol Ocak, et al. "Low pan-immune-inflammation-value predicts better chemotherapy response and survival in breast cancer patients treated with neoadjuvant chemotherapy." Scientific Reports 11, no. 1 (2021). http://dx.doi.org/10.1038/s41598-021-94184-7.

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AbstractBlood-based biomarkers reflect systemic inflammation status and have prognostic and predictive value in solid malignancies. As a recently defined biomarker, Pan-Immune-Inflammation-Value (PIV) integrates different peripheral blood cell subpopulations. This retrospective study of collected data aimed to assess whether PIV may predict the pathological complete response (pCR) to neoadjuvant chemotherapy (NAC) in Turkish women with breast cancer. The study consisted of 743 patients with breast cancer who were scheduled to undergo NAC before attempting cytoreductive surgery. A pre-treatment
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14

Badr, Aly Abdelkawy, Amira Ahmed Abozaid, Marwa Mohamed Wahsh, and Tarek Salah Morsi. "Fracture Resistance of Anterior CAD/CAM Nanoceramic Resin Endocrowns with Different Preparation Designs." Brazilian Dental Science 24, no. 3 (2021). http://dx.doi.org/10.14295/bds.2021.v24i3.2384.

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Objective: The aim of the study was to evaluate the effect of extension of endocrown in pulp space and the effect of ferrule on the fracture resistance of anterior endocrowns made of nano-ceramic resin blocks. Material and Methods: Twenty-eight freshly extracted human upper central incisor teeth were prepared to receive CAD/CAM nanoceramic resin endocrowns with four different designs. The specimens were divided into two groups (n = 14) according to the extension of the endocrown inside root canal (A:short and B:long), then each group was further subdivided into another two subgroups (n = 7) ac
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15

Kamel, Mohamed A., Hesham H. Mohammed, and Nora E. Abdel-Hamid. "NEUROCHEMICAL, HEMATOLOGICAL AND BEHAVIORAL ALTERATIONS RELATED TO ESZOPICLONE ADMINISTRATION IN RATS." Slovenian Veterinary Research 55, no. 20-Suppl (2018). http://dx.doi.org/10.26873/svr-626-2018.

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This study aimed to shed light on the effect of eszopiclone (ESZ) administration once daily for 30 consecutive days at night time on some neurochemical, behavioral and hematological criteria. A total of 27 male Wister albino rats were assigned to one of three drug treatment groups, vehicle, Eszopiclone (3mg/kg) and (6mg/kg). After 30 days of Eszopiclone administration, the neurochemical analysis revealed a significant reduction in serotonin and glutamate (306.44 ng/ml, 4.33 nmol /μl, respectively) in 6mg/kg treated animals, furthermore dopamine levels were significantly higher in rats treated
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16

Yagi, Ryuichiro, Yuichiro Mori, Shinichi Goto, Taku Iwami, and Kosuke Inoue. "Routine Electrocardiogram Screening and Cardiovascular Disease Events in Adults." JAMA Internal Medicine, July 1, 2024. http://dx.doi.org/10.1001/jamainternmed.2024.2270.

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ImportanceThe resting electrocardiogram (ECG) is commonly performed for cardiovascular disease (CVD) screening purposes in Japan. However, evidence is limited regarding the prognostic significance of ECG in clinical practice settings.ObjectiveTo investigate the association between ECG abnormalities and CVD outcomes in a working-age population.Design, Setting, and ParticipantsThis nationwide cohort study included individuals aged 35 to 65 years from the Japan Health Insurance Association database, which covers approximately 40% (30 million) of the working-age population in Japan. Data from Apri
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17

Akbarifard, Saeid, Mohammad Reza Sharifi, Kourosh Qaderi, and Mohamad Reza Madadi. "Optimal operation of multi-reservoir systems: comparative study of three robust metaheuristic algorithms." Water Supply, December 15, 2020. http://dx.doi.org/10.2166/ws.2020.368.

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Abstract In this study, the capability of recently introduced Moth Swarm Algorithm (MSA) was compared with two robust meta-heuristics of harmony search (HS) algorithm and imperialist competitive algorithm (ICA). First, the performance of these algorithms was assessed by seven benchmark functions having 2–30 dimensions. Next, they were compared in optimization of complex problem of 4-reservoir and 10-reservoir systems operation. Furthermore, the results of these algorithms were compared with nine other metaheuristic algorithms developed by several researchers. Sensitivity analysis was performed
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18

Llinàs-Mallol, Laura, Betty Odette Chamoun Huacon, Dolores Redondo Pachon, et al. "MO948: Impact of DE Novo Immunosuppression in The Covid-19 Serological Status at Kidney Transplantation." Nephrology Dialysis Transplantation 37, Supplement_3 (2022). http://dx.doi.org/10.1093/ndt/gfac087.006.

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Abstract BACKGROUND AND AIMS COVID-19 infection has heavily impacted our national health system since March-2020. Although the kidney transplant (KT) activity was strongly reduced initially, nowadays it is partially recovered by using ‘COVID-clean’ pathways and vaccination of KT candidates since February-2021. However, scarce information is available regarding how de novo KT immunosuppression influences the serological status of vaccinated recipients. METHOD We reviewed the course of 38 de novo KT recipients transplanted between March-September 2021 fully vaccinated before KT. SARS-CoV-2 IgG a
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Syafi'i, Ahmad Ali, Riswan Riswan, Romla Noor Hakim, Uyu Saismana, and Kartini Kartini. "EVALUASI ISIAN BAHAN PELEDAK MENGGUNAKAN ANALISIS DISTRIBUSI UKURAN FRAGMEN PADA PELEDAKAN BATUAN PENUTUP DI TAMBANG TERBUKA BATUBARA." Jurnal Himasapta 1, no. 01 (2019). http://dx.doi.org/10.20527/jhs.v1i01.910.

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Peledakan dikatakan berhasil apabila batuan terberai menjadi fragmen dengan ukuran yang tepat untuk proses lanjutan. Proses lanjutan setelah pemberaian batuan penutup berupa pemuatan dan pengangkutan ke tempat penimbunan (disposal). Ukuran fragmen hasil peledakan harus sedapat mungkin mudah dimuat oleh alat muat yang beroperasi di lokasi peledakan saat itu. Permasalahan yang terjadi di lokasi penelitian ialah fragmen hasil peledakan yang berukuran ³ 70 cm sekitar 35%. Sedangkan perusahaan menargetkan maksimal 30%. Fragmentasi erat kaitannya dengan perbandingan isian bahan peledak terhadap batu
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Okabe, K., J. Itonaga, K. Ikuta, et al. "Efficacy of bepridil as a periprocedural support drug in atrial fibrillation patients with left ventricular systolic dysfunction undergoing catheter ablation." European Heart Journal 44, Supplement_2 (2023). http://dx.doi.org/10.1093/eurheartj/ehad655.332.

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Abstract We previously reported that sinus restoration either with drugs or DC cardioversion prior to catheter ablation (CA) was associated with a better outcome in persistent atrial fibrillation (AF). As an antiarrhythmic agent for persistent AF, amiodarone is recommended for patients with structural heart disease. Bepridil, a unique multichannel inhibitor, has a comparable defibrillation efficacy and fewer extracardiac complications than amiodarone, although safety and efficacy of bepridil has not been established in those with left ventricular (LV) systolic dysfunction. We compared the safe
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Machi, Jacqueline F., Nathalia Bernardes, Danielle Dias, et al. "Abstract 616: Aging, Menopause And Metabolic Syndrome As Related To The Beneficial Effects Of Exercise Training." Hypertension 64, suppl_1 (2014). http://dx.doi.org/10.1161/hyp.64.suppl_1.616.

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Menopause and aging are associated with increased blood pressure. High fructose may modify the development of the pathologies associated with these conditions. The objective was to investigate the effects of exercise training (ET) in aged, oophorectomy mimic of menopause fructose-fed rats. Female Wistar rats (24 months old) were ovariectomized, fed with fructose (100g/L) in drinking water and divided in 5 groups (n=8/group): control (C), ovariectomized (O), ovariectomized trained (OT, n= 8), ovariectomized fructose (OF, n= 8) and ovariectomized fructose trained (OFT, n= 8). The ET was performe
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22

Bayat, Alper Halil, Gozde Aksoy Aydemir, Emre Aydemir, et al. "Histopathologische Veränderungen der Bindehaut und klinischer Tränenfilm bei Kindern mit atopischer Dermatitis." Klinische Monatsblätter für Augenheilkunde, July 30, 2024. http://dx.doi.org/10.1055/a-2376-3114.

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Abstrakt Zweck: Die Beurteilung von Veränderungen der Augenoberfläche bei Kindern mit der Diagnose atopische Dermatitis (AD) Methoden: In dieser prospektiven Fallkontrollstudie wurden die Augen von 36 Kindern mit der Diagnose AD (Augen-AD-Gruppe) und 40 gesunden Probanden (Augen-HS-Gruppe) aufgenommen. Die Werte für die Aufreißzeit des Tränenfilms (T-BUT), den Schirmer-Tränentest (STT), die konjunktivale Impressionszytologie (CIC), die Tränenmeniskushöhe (TMH), die Tränenmeniskusfläche (TMA) und den Augenoberflächenkrankheitsindex (OSDI) wurden ermittelt und gesammelt. Ergebnisse: Die Teilnehm
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