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Journal articles on the topic '32.001 + 34.02 (043.2)'

Author: Grafiati

Published: 30 May 2022

Last updated: 31 July 2025

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1

Kampf, Anthony R., Jakub Plášil, Barbara P. Nash, Ivan Němec, and Joe Marty. "Uroxite and metauroxite, the first two uranyl oxalate minerals." Mineralogical Magazine 84, no. 1 (2019): 131–41. http://dx.doi.org/10.1180/mgm.2019.57.

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AbstractUroxite (IMA2018-100), [(UO2)2(C2O4)(OH)2(H2O)2]⋅H2O, and metauroxite (IMA2019-030), (UO2)2(C2O4)(OH)2(H2O)2, are the first two uranyl oxalate minerals. Uroxite was found in the Markey mine, Red Canyon, San Juan County, Utah, USA and in the Burro mine, Slick Rock district, San Miguel County, Colorado, USA. Metauroxite was found only in the Burro mine. Both minerals are post-mining secondary phases found in efflorescent crusts on mine walls. Uroxite occurs as light yellow striated blades exhibiting moderate neon-green fluorescence, ca 2 Mohs hardness with good {101} and {010} cleavages.

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Al-Kaisey, Ahmed M., Ramanathan Parameswaran, Christina Bryant, et al. "Atrial Fibrillation Catheter Ablation vs Medical Therapy and Psychological Distress." JAMA 330, no. 10 (2023): 925. http://dx.doi.org/10.1001/jama.2023.14685.

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ImportanceThe impact of atrial fibrillation (AF) catheter ablation on mental health outcomes is not well understood.ObjectiveTo determine whether AF catheter ablation is associated with greater improvements in markers of psychological distress compared with medical therapy alone.Design, Setting, and ParticipantsThe Randomized Evaluation of the Impact of Catheter Ablation on Psychological Distress in Atrial Fibrillation (REMEDIAL) study was a randomized trial of symptomatic participants conducted in 2 AF centers in Australia between June 2018 and March 2021.InterventionsParticipants were random

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Frick, Mareike, Christopher Maximilian Arends, Joel Galan-Sousa, et al. "Clonal Hematopoiesis: Cell of Origin, Lineage Repartition and Dynamic Evolution during Chemotherapy." Blood 130, Suppl_1 (2017): 632. http://dx.doi.org/10.1182/blood.v130.suppl_1.632.632.

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Abstract Background: Clonal hematopoiesis of indeterminate potential (CHIP) is defined by the presence of hematologic cancer associated mutations in the peripheral blood (PB) of at least 10% of elderly people without history of hematologic disorders (Genovese et al ., NEJM, 2014; Jaiswal et al ., NEJM, 2014). At present, caution is needed when predicting clinical consequences from CHIP in healthy people. An essential step towards a better understanding of CHIP requires identification of the cell of origin, clonal expansion patterns within the hematopoietic differentiation tree, and its dynamic

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Newbold, J. R., P. C. Garnsworthy, P. J. Buttery, D. J. A. Cole та W. Haresign. "Responses of British Friesian steers with or without implants of oestradiol-17β to undegradable dietary protein". Animal Science 46, № 2 (1988): 181–93. http://dx.doi.org/10.1017/s0003356100042239.

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AbstractThe ability of the protein nutrition scheme proposed by the Agricultural Research Council (ARC, 1980, 1984) to predict responses to protein supply was examined in two experiments. In experiment 1, groups of nine British Friesian steers implanted with oestradiol-17β and nine non-implanted steers were fed from 133 to 300 kg live weight on each of four all-concentrate diets (metabolizable energy (ME) = 12 MJ/kg dry matter (DM)) containing ratios of soya-bean meal and formaldehyde-treated soya-bean meal such that undegradable protein (UDP) concentration was 19, 25, 32 or 42 g/kg DM. Rumen

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Katamesh, Bahga, Amrutha Mittapalli, Rong He, et al. "STAG2 and PHF6: Comparison of 2 X-Linked Gene Mutations in Myeloid Neoplasms." Blood 142, Supplement 1 (2023): 4304. http://dx.doi.org/10.1182/blood-2023-178244.

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INTRODUCTION: The Stromal Antigen 2 ( STAG2), on Xq25, is the most common cohesin complex gene mutated in myeloid neoplasms (MN) (5-10%). STAG2 mutations ( STAG2m) were incorporated in the ELN2022 as AML-MDS defining genetic mutations inferring poor prognosis and is a genetic marker in IPSS-M risk stratification. The PHD-finger protein 6 ( PHF6) gene, on Xq26.3, is a tumor suppressor gene, mutated in 3% of MN, and is more common in T-ALL. PHF6m is believed to be a late event in MN with little data on its prognostic implications in MN. Both STAG2m and PHF6m are more prevalent in males, but thei

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Liu, Yang, Ali Tabarroki, Valeria Visconte, et al. "A Prognostic Scoring System for Unclassifiable MDS and MDS/MPN." Blood 120, no. 21 (2012): 1701. http://dx.doi.org/10.1182/blood.v120.21.1701.1701.

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Abstract Abstract 1701 Patients with features of MDS and MDS/MPN who do not fulfill diagnostic criteria for a specific subtype of MDS and MDS/MPN are categorized by the WHO 2008 diagnostic criteria as MDS-U and MDS/MPN-U. MDS includes RCUD, RCMD, RARS, RAEB-1, RAEB-2, MDS-U and 5q- syndrome while MDS/MPN includes CMML, JMML, atypical CML and MDS/MPN-U. The natural history of patients who belong to these disease subtypes are hetergeneous. Although included in currently accepted prognostic scoring schemes like the International Prognostic Scoring System (IPSS) in MDS, Revised IPSS, and MD Anders

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Riaz, Wasif, John Pham, Ling Zhang, et al. "Prognostic Significance of VLA4 and CD44 Expression by Flow Cytometry in Multiple Myeloma (MM)." Blood 120, no. 21 (2012): 4975. http://dx.doi.org/10.1182/blood.v120.21.4975.4975.

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Abstract Abstract 4975 Background: Our group has developed a peptide referred to as HYD1 which binds VLA-4 integrin/CD44 containing complex and induces necrotic cell death in myeloma cells (Nair et al Mol Cancer Ther 2009, Emmons et al, Mol Cancer Ther, 2011). Furthermore, we previously demonstrated in a small subset of MM patients that HYD1 was more active in specimens obtained from relapsed/refractory patients, a finding that correlated with VLA-4 expression. The frequency of expression and prognostic significance of two key surface markers VLA4 (very late antigen 4) and CD44 in patients wit

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Duàn, Hanna, Emmi Jokinen, Hanna Lähteenmäki, et al. "Genomic Subtypes of AML Define Sensitivity to NK Cell Cytotoxicity." Blood 144, Supplement 1 (2024): 329. https://doi.org/10.1182/blood-2024-199448.

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Acute myeloid leukemia (AML) is characterized by poor prognosis and remains a challenging disease to treat. New therapeutic approaches are being introduced, and natural killer (NK) cell-based immunotherapy has been recognized as a promising option. However, which subgroups of AML patients that are most likely to respond to NK cell therapy, remain undefined. We explored the susceptibility of AML cells to NK cell cytotoxicity in ex vivo co-cultures. We analyzed leukemic cell sensitivity to NK cells using vitally frozen bone marrow (BM) samples from 99 AML patients at diagnosis and expanded NK ce

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9

Kröger, Nicolaus, Ernst Holler, Guido Kobbe, et al. "Allogeneic stem cell transplantation after reduced-intensity conditioning in patients with myelofibrosis: a prospective, multicenter study of the Chronic Leukemia Working Party of the European Group for Blood and Marrow Transplantation." Blood 114, no. 26 (2009): 5264–70. http://dx.doi.org/10.1182/blood-2009-07-234880.

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Abstract From 2002 to 2007, 103 patients with primary myelofibrosis or postessential thrombocythemia and polycythemia vera myelofibrosis and a median age of 55 years (range, 32-68 years) were included in a prospective multicenter phase 2 trial to determine efficacy of a busulfan (10 mg/kg)/fludarabine (180 mg/m2)–based reduced-intensity conditioning regimen followed by allogeneic stem cell transplantation from related (n = 33) or unrelated donors (n = 70). All but 2 patients (2%) showed leukocyte and platelet engraftment after a median of 18 and 22 days, respectively. Acute graft-versus-host d

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Einsele, H., G. Ehninger, H. Hebart, et al. "Polymerase chain reaction monitoring reduces the incidence of cytomegalovirus disease and the duration and side effects of antiviral therapy after bone marrow transplantation." Blood 86, no. 7 (1995): 2815–20. http://dx.doi.org/10.1182/blood.v86.7.2815.2815.

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Abstract Culture-based preemptive therapy with ganciclovir was shown to reduce the incidence of cytomegalovirus (CMV) disease after bone marrow transplantation (BMT). Culture techniques did not detect CMV in 12% to 13% of patients before the onset of CMV disease. In a prospective study, 71 patients either received preemptive therapy based on polymerase chain reaction (PCR) technique (37 patients) or on culture assays (34 patients). In both groups, therapy was continued until clinical signs disappeared and PCR negativity was documented. Twenty-two patients in the PCR group and 15 patients in th

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Einsele, H., G. Ehninger, H. Hebart, et al. "Polymerase chain reaction monitoring reduces the incidence of cytomegalovirus disease and the duration and side effects of antiviral therapy after bone marrow transplantation." Blood 86, no. 7 (1995): 2815–20. http://dx.doi.org/10.1182/blood.v86.7.2815.bloodjournal8672815.

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Culture-based preemptive therapy with ganciclovir was shown to reduce the incidence of cytomegalovirus (CMV) disease after bone marrow transplantation (BMT). Culture techniques did not detect CMV in 12% to 13% of patients before the onset of CMV disease. In a prospective study, 71 patients either received preemptive therapy based on polymerase chain reaction (PCR) technique (37 patients) or on culture assays (34 patients). In both groups, therapy was continued until clinical signs disappeared and PCR negativity was documented. Twenty-two patients in the PCR group and 15 patients in the culture

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Zhang, Shuo, Feng Mei, Yan Shi, et al. "Impact of COVID-19 on acute angle-closure attack: A retrospective study." Medicine 103, no. 49 (2024): e40782. https://doi.org/10.1097/md.0000000000040782.

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To systematically review the characteristics of patients experiencing acute angle closure (AAC) attacks during the COVID-19 outbreak in Beijing. Patients with AAC attacks during the COVID-19 epidemic and those in the same period the following year were recruited. Demographic characteristics, ocular biometry, ocular signs, sequential relationships, and the prognosis of operative management outcome were recorded and compared between the 2 groups. We included 60 eyes of 55 patients with AAC attacks in the COVID-19 group and 34 eyes of 33 patients in the control group. There was a significantly hi

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Gass, Carlton, Brooke Patten, and Alanna O’Maille. "A-201 Attention Span, Verbal Memory, and Spatial Memory as Variables in Neuropsychological Test Performance." Archives of Clinical Neuropsychology 37, no. 6 (2022): 1356. http://dx.doi.org/10.1093/arclin/acac060.201.

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Abstract Objective: We investigated (a) the role of attention span, verbal, and spatial memory in performance on widely used neuropsychological tests, and; (b) the impact of anxiety and depression on tests of attention span and verbal and spatial memory. Participants and Method: 579 referrals to memory disorders clinic, 60% women, 84% white non-Hispanic, average age 59.8±15.7 and education 14.9±2.9 years. Referred to help diagnose symptoms of forgetfulness, distractibility, and/or word finding difficulties. Used comprehensive battery (HRNES-R) and protocols were screened for performance invali

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Gerds, Aaron T., Matt E. Kalaycio, Kwang Woo Ahn, et al. "Outcomes after Umbilical Cord Blood Transplantation for Myelodysplastic Syndromes: A Center for International Blood and Marrow Transplant Registry (CIBMTR®) Study." Blood 126, no. 23 (2015): 2003. http://dx.doi.org/10.1182/blood.v126.23.2003.2003.

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Abstract Background: Although, widespread application of innovative sequencing technologies is rapidly unraveling the molecular underpinnings driving the pathogenesis of myelodysplastic syndromes (MDS), allogeneic hematopoietic cell transplantation (HCT) remains the only therapeutic modality that has demonstrated curative potential. However, a significant proportion of patients lack a human leukocyte antigen (HLA)-matched sibling or unrelated donor, and alternative donor sources are needed to extend HCT to patients that are otherwise suitable. There have been few published series solely dedica

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Zardavas, Dimitrios, Luc te Marvelde, Roger L. Milne, et al. "Tumor PIK3CA Genotype and Prognosis in Early-Stage Breast Cancer: A Pooled Analysis of Individual Patient Data." Journal of Clinical Oncology 36, no. 10 (2018): 981–90. http://dx.doi.org/10.1200/jco.2017.74.8301.

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Purpose Phosphatidylinositol-4, 5-bisphosphate 3-kinase catalytic subunit alpha ( PIK3CA) mutations are frequently observed in primary breast cancer. We evaluated their prognostic relevance by performing a pooled analysis of individual patient data. Patients and Methods Associations between PIK3CA status and clinicopathologic characteristics were tested by applying Cox regression models adjusted for age, tumor size, nodes, grade, estrogen receptor (ER) status, human epidermal growth factor receptor 2 (HER2) status, treatment, and study. Invasive disease-free survival (IDFS) was the primary end

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Newell, Abigail, Elizabeth A. Szamreta, Erica E. Fortune, Maria Belen Gonzalo, M. Claire Saxton, and Elif Andac-Jones. "Sleep disturbance and fatigue in patients with ovarian cancer during chemotherapy and surgery compared to PARPi maintenance therapy." Journal of Clinical Oncology 42, no. 16_suppl (2024): e23248-e23248. http://dx.doi.org/10.1200/jco.2024.42.16_suppl.e23248.

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e23248 Background: Sleep disturbance and fatigue are prevalent among advanced ovarian cancer (OC) patients and are associated with poor health outcomes. It is unclear how sleep disturbance and fatigue vary across treatment timelines. This study evaluated how patients rate their sleep disturbance and fatigue levels at different points in their treatment trajectory. Methods: 200 U.S. patients with stage III/IV OC diagnosed in 2020-2023 were enrolled. Survey items asked patients to retrospectively assess their sleep disturbance and fatigue levels prior to diagnosis, during treatment, and presentl

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Phillips, Gregory S., Jennifer Wu, Matthew D. Hellmann, et al. "Treatment Outcomes of Immune-Related Cutaneous Adverse Events." Journal of Clinical Oncology 37, no. 30 (2019): 2746–58. http://dx.doi.org/10.1200/jco.18.02141.

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PURPOSE The aim of the current study was to report the efficacy of topical and systemic treatments for immune-related cutaneous adverse events (ircAEs) attributed to checkpoint inhibitors in an uncontrolled cohort of patients referred to oncodermatology clinics. METHODS A retrospective analysis of patients with ircAEs evaluated by dermatologists from January 1, 2014, to December 31, 2017, at three tertiary care hospitals and cancer centers were identified through electronic medical records. Clinicopathologic characteristics, dermatologic therapy outcome, and laboratory data were analyzed. RESU

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Zhao, Bing, Xianxi Tan, Yuanli Zhao, et al. "Variation in Patient Characteristics and Outcomes Between Early and Delayed Surgery in Poor-Grade Aneurysmal Subarachnoid Hemorrhage." Neurosurgery 78, no. 2 (2015): 224–31. http://dx.doi.org/10.1227/neu.0000000000001038.

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ABSTRACT BACKGROUND: There is no consensus regarding the optimal timing for surgery for poor-grade aneurysmal subarachnoid hemorrhage. OBJECTIVE: To retrospectively evaluate variation in patient characteristics and outcomes between early and delayed surgery groups. METHODS: Poor-grade aneurysmal subarachnoid hemorrhage was defined as a World Federation of Neurosurgical Societies grade of IV or V after resuscitation. Early surgery was defined as surgery performed within 72 hours of ictus, and delayed surgery was defined as surgery after 72 hours. Outcomes were assessed by modified Rankin score.

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Gascoyne, Randy D., Sheryle A. Adomat, Stanislaw Krajewski, et al. "Prognostic Significance of Bcl-2 Protein Expression and Bcl-2 Gene Rearrangement in Diffuse Aggressive Non-Hodgkin's Lymphoma." Blood 90, no. 1 (1997): 244–51. http://dx.doi.org/10.1182/blood.v90.1.244.

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Abstract The prognostic significance of Bcl-2 protein expression and bcl-2 gene rearrangement in diffuse large cell lymphomas (DLCL) is controversial. Bcl-2 protein expression prevents apoptosis and may have an important role in clinical drug resistance. The presence of a bcl-2 gene rearrangement in de novo DLCL suggests a possible follicle center cell origin and perhaps a distinct clinical behavior more akin to low-grade non-Hodgkin's lymphoma (NHL). The purpose of this study was to determine the impact of Bcl-2 protein expression and bcl-2 gene rearrangement (mbr and mcr) on survival of a co

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Gascoyne, Randy D., Sheryle A. Adomat, Stanislaw Krajewski, et al. "Prognostic Significance of Bcl-2 Protein Expression and Bcl-2 Gene Rearrangement in Diffuse Aggressive Non-Hodgkin's Lymphoma." Blood 90, no. 1 (1997): 244–51. http://dx.doi.org/10.1182/blood.v90.1.244.244_244_251.

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The prognostic significance of Bcl-2 protein expression and bcl-2 gene rearrangement in diffuse large cell lymphomas (DLCL) is controversial. Bcl-2 protein expression prevents apoptosis and may have an important role in clinical drug resistance. The presence of a bcl-2 gene rearrangement in de novo DLCL suggests a possible follicle center cell origin and perhaps a distinct clinical behavior more akin to low-grade non-Hodgkin's lymphoma (NHL). The purpose of this study was to determine the impact of Bcl-2 protein expression and bcl-2 gene rearrangement (mbr and mcr) on survival of a cohort of p

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Swords, Chloe, Reshma Ghedia, Hannah Blanchford, et al. "Socioeconomic and ethnic disparities associated with access to cochlear implantation for severe-to-profound hearing loss: A multicentre observational study of UK adults." PLOS Medicine 21, no. 4 (2024): e1004296. http://dx.doi.org/10.1371/journal.pmed.1004296.

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Background Patients with severe-to-profound hearing loss may benefit from management with cochlear implants. These patients need a referral to a cochlear implant team for further assessment and possible surgery. The referral pathway may result in varied access to hearing healthcare. This study aimed to explore referral patterns and whether there were any socioeconomic or ethnic associations with the likelihood of referral. The primary outcome was to determine factors influencing referral for implant assessment. The secondary outcome was to identify factors impacting whether healthcare professi

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Zhai, DongHui, Ruud van Stiphout, Giuseppina Schiavone, Walter De Raedt, and Chris Van Hoof. "Characterizing and Modeling Smoking Behavior Using Automatic Smoking Event Detection and Mobile Surveys in Naturalistic Environments: Observational Study." JMIR mHealth and uHealth 10, no. 2 (2022): e28159. http://dx.doi.org/10.2196/28159.

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Background There are 1.1 billion smokers worldwide, and each year, more than 8 million die prematurely because of cigarette smoking. More than half of current smokers make a serious quit every year. Nonetheless, 90% of unaided quitters relapse within the first 4 weeks of quitting due to the lack of limited access to cost-effective and efficient smoking cessation tools in their daily lives. Objective This study aims to enable quantified monitoring of ambulatory smoking behavior 24/7 in real life by using continuous and automatic measurement techniques and identifying and characterizing smoking

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Serio, Bianca, Giridharan Ramsingh, Ramon Tiu, Antonio M. Risitano, Mikkael A. Sekeres та Jaroslaw M. D. Maciejewski. "Immunogenetic Analysis Reveals the Association of INF-γ (+874 A/T) Hypersecretor Genotype in AA and a Low Frequency of KIR-2DL3/C1 Mismatch in Responders to Immunosuppression." Blood 110, № 11 (2007): 1700. http://dx.doi.org/10.1182/blood.v110.11.1700.1700.

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Abstract Clinical and laboratory evidence support an immune pathogenesis in most cases of idiopathic aplastic anemia (AA) and closely related disorders such as paroxysmal nocturnal hemoglobinuria (PNH). While external triggers are likely necessary, a complex constellation of immunogenetic factors may determine disease susceptibility. Many immunogenetic factors can influence the quality of immune response and affect the propensity to immune-mediated attack on hematopoietic stem cells in AA. Here we investigated whether KIR and KIR-L (HLA-A) genotype and cytokine/receptor gene variants are over-

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Kampf, A. R., S. J. Mills, R. M. Housley, P. A. Williams, and M. Dini. "Alcaparrosaite, K3Ti4+Fe3+(SO4)4O(H2O)2, a new hydrophobic Ti4+ sulfate from Alcaparrosa, Chile." Mineralogical Magazine 76, no. 4 (2012): 851–61. http://dx.doi.org/10.1180/minmag.2012.076.4.03.

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AbstractAlcaparrosaite, ideally K3Ti4+Fe3+(SO4)4O(H2O)2, is a new mineral from the Alcaparrosa mine, Cerritos Bayos, El Loa Province, Antofagasta, Chile (IMA2011-024). The mineral occurs on and intergrown with coquimbite, and is also associated with ferrinatrite, krausite, pertlikite, pyrite, tamarugite and voltaite. It is a relatively early phase which forms during the oxidation of pyritic masses under increasingly arid conditions. Alcaparrosaite crystallizes from hyperacidic solutions in a chemical environment that is consistent with its association with coquimbite. It occurs as pale yellow

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Murillo, Ilda, Marcio M. Andrade, Anel Montes, Jose M. Grasa, and Pilar Giraldo. "Are IgM Hevylite® Immunoglobulin Heavy Chain/Light Chain Analysis a Useful Tool to Differentiate IgM MGUS From Waldenström Macroglobulinemia?" Blood 120, no. 21 (2012): 5097. http://dx.doi.org/10.1182/blood.v120.21.5097.5097.

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Abstract Abstract 5097 Background: Monoclonal IgM is the biomarker that characterize to Waldenstrom's macroglobulinemia (WM), a rare low grade B-cell lymphoma derived of the lymphoplasmacytic cell, even serum IgM component also is presented in MGUS. Recently new determinations of heavy chain/light chain immunoglobulins pairs (HLC) have been developed as biomarkers to apply to every day clinical practice. The diagnostic and prognostic potential of these biomarkers is under investigation. The aim of this study is to present our experience in the use of free light chain assay (sFLC) and HLC as bi

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Aguirre, Luis E., Jan Philipp Bewersdorf, Yiwen Liu, et al. "Comparative Analysis of Outcomes with HMA Plus Venetoclax Vs Intensive Chemotherapy in AML Patients Harboring Very-High Risk Cytogenetics." Blood 144, Supplement 1 (2024): 4267. https://doi.org/10.1182/blood-2024-202744.

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Background: Dismal survival outcomes are characteristic of pts with AML harboring very-high risk cytogenetics (vHRC), which can be attributed to aggressive disease biology and low and poorly durable response rates to conventional cytotoxic chemotherapy. Allogeneic hematopoietic stem cell transplant (alloSCT) is the preferred treatment strategy after major disease reduction with initial chemotherapy. However, it is unclear whether pts with AML-vHRC should be treated with intensive chemotherapy (IC) or hypomethylating agents plus venetoclax (HMA+ven) to achieve such responses. In this large mult

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Bedenne, Laurent, Pierre Michel, Olivier Bouché, et al. "Chemoradiation Followed by Surgery Compared With Chemoradiation Alone in Squamous Cancer of the Esophagus: FFCD 9102." Journal of Clinical Oncology 25, no. 10 (2007): 1160–68. http://dx.doi.org/10.1200/jco.2005.04.7118.

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Purpose Uncontrolled studies suggest that chemoradiation has similar efficacy as surgery for esophageal cancer. Therefore, a randomized trial was carried out to compare, in responders only, chemoradiation alone with chemoradiation followed by surgery in patients with locally advanced tumors. Patients and Methods Eligible patients had operable T3N0-1M0 thoracic esophageal cancer. Patients received two cycles of fluorouracil (FU) and cisplatin (days 1 to 5 and 22 to 26) and either conventional (46 Gy in 4.5 weeks) or split-course (15 Gy, days 1 to 5 and 22 to 26) concomitant radiotherapy. Patien

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Traina, Fabiola, Anna M. Jankowska, Valeria Visconte, et al. "Impact of Molecular Mutations on Treatment Response to Hypomethylating Agents in MDS." Blood 118, no. 21 (2011): 461. http://dx.doi.org/10.1182/blood.v118.21.461.461.

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Abstract Abstract 461 Aberrant DNA methylation is a hallmark of myelodysplastic syndromes (MDS), MDS/myeloproliferative neoplasms (MDS/MPN) and secondary acute myeloid leukemia (sAML). It provides a rationale for treating these malignancies with hypomethylating agents like 5-azacitidine (AZA) and decitabine (DAC). However, treatment outcomes remain limited and heavily weighed on morphologic/cytogenetic results. The discovery of novel mutations has provided important insight into the pathogenesis of MDS and related disorders. Genes implicated in epigenetic regulation, including DNMT3A, TET2, ID

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Jourdan, Eric, Jean-Michel Boiron, Nicole Dastugue, et al. "Early Allogeneic Bone Marrow Transplantation for Young Adults with Acute Myeloid Leukemia in First Complete Remission: The 17 Year Experience of the BGMT Group." Blood 104, no. 11 (2004): 619. http://dx.doi.org/10.1182/blood.v104.11.619.619.

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Abstract Background. From 1984 and during 17 years, the BGMT inter-group prospectively followed the same strategy of early allogeneic bone marrow transplantation (alloBMT) compared to non allogeneic treatment in 4 consecutive trials, as modality of consolidation for patients (pts) under 45 with an HLA identical sibling donor in first complete remission (CR) of an acute myeloid leukemia (AML). The purpose of this study was to evaluate this strategy by an intent to treat analysis based on donor availability. Pts and methods. In each of these trials, pts received an induction by daunorubicine 60

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Parmar, S., M. Fernandez-Vina, P. Liu, et al. "Influence of Allele Level HLA Typing on Unrelated Donor (UD) Transplantation for High Risk Myeloid Leukemias." Blood 106, no. 11 (2005): 2916. http://dx.doi.org/10.1182/blood.v106.11.2916.2916.

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Abstract Donor-recipient histocompatibility is a major determinant of outcome after UD HSCT, and matching pairs by high-resolution (Hi-res) HLA typing is likely to improve results. Methods: We studied 66 pts with myeloid leukemias in complete remission (CR) transplanted with UD bone marrow (n=58) or peripheral blood (n=8) from 01/02 to 12/04. Preparative regimens were ablative [Busulfan (Bu)/Cyclophosphamide (Cy)(n=13), Cy/TBI (n=2), Fludarabine (Flu)/Bu 130 mg/m2x4 doses (n=33)] and reduced intensity [Flu/Bu 130 mg/m2x2 doses+Gleevec (n=7), Flu/Melphalan 140mg/m2 (n=11)]. ATG was given in 61

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Ram, Ron, Ted Gooley, David G. Maloney, et al. "Outcomes of Early Relapse Following Non-Myeloablative Allogeneic Transplant for Lymphoma." Blood 114, no. 22 (2009): 1204. http://dx.doi.org/10.1182/blood.v114.22.1204.1204.

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Abstract Abstract 1204 Poster Board I-226 Non-myeloablative allogeneic transplantation (NMAT) has provided the potential benefit of allogeneic hematopoietic stem cell transplantation (allo-SCT) to a broader cohort of lymphoma patients via lowered non-relapse mortality (NRM). NMAT also provides a post-transplant platform of a chemotherapy-naïve graft for both myelosuppressive and immune-mediated anti-tumor therapies, though the lack of high-dose conditioning may also heighten the risk for early relapse. Herein, we describe the survival as well as factors associated with outcomes for lymphoma p

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Curtis, Lauren M., David Venzon, Fran T. Hakim, et al. "Final Results of a Randomized Phase 2 Trial Evaluating Lower-Dose Versus Higher-Dose Pomalidomide as Therapy for Corticosteroid-Refractory Chronic Gvhd." Blood 128, no. 22 (2016): 507. http://dx.doi.org/10.1182/blood.v128.22.507.507.

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Abstract Chronic graft-versus-host disease (cGvHD) is the leading cause of late non-relapse morbidity and mortality after allogeneic HCT. There is no standard therapy for steroid-refractory disease. Thalidomide, an immune-modulating drug, showed some activity in advanced sclerotic cGvHD but was difficult to tolerate at active doses. Pomalidomide (Pom) is related to thalidomide, but with higher potency and a more favorable toxicity profile. A pilot study suggested Pom was effective in cGvHD, however doses >2 mg/day were poorly tolerated (Pusic et al, BMT, 2016;51:612). In this randomized pha

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Orvain, Corentin, Sylvain Chantepie, Xavier Thomas, et al. "Impact of Central Nervous System Involvement in Adult Patients with Acute Lymphoblastic Leukemia Treated in a Pediatrics-Inspired Protocol - a Graall Study." Blood 138, Supplement 1 (2021): 215. http://dx.doi.org/10.1182/blood-2021-150705.

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Abstract Background: The prognosis of central nervous system (CNS) involvement in adult patients with acute lymphoblastic leukemia (ALL) has been historically associated with a dismal outcome. Whereas the prognosis of adult patients with ALL has greatly improved since the advent of pediatrics-inspired regimens, the prognostic impact of CNS involvement has not been formerly reevaluated. We report herein the impact of CNS involvement in patients included in the pediatric-inspired prospective GRAALL-2005 study. Methods: All patients received a 5-drug induction therapy with native E. Coli-ASP intr

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Jankowska, Anna, Hideki Makishima, Ramon V. Tiu, et al. "Mutational Spectrum In Chronic Myelomonocytic Leukemia Includes Genes Associated with Epigenetic Regulation Such as UTX and EZH2." Blood 116, no. 21 (2010): 611. http://dx.doi.org/10.1182/blood.v116.21.611.611.

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Abstract Abstract 611 Chronic myelomonocytic leukemia (CMML), a myelodysplastic/myeloproliferative overlap neoplasm, is characterized by monocytic proliferation, cytomorphologic dysplasia and frequent progression to acute myelogeneous leukemia (AML). The molecular basis of CMML is poorly defined, although somatic mutations in a number of genes have recently been identified in a proportion of patients. Single nucleotide polymorphisms array (SNP-A) technologies have improved the definition of shared regions of loss of heterozygosity (LOH), including uniparental disomy (UPD) and facilitated disco

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Freire, Joselyn, Maritza Vaca, and Manuel Almeida. "LAVADO DE FIBRA DE ALPACA (Vicugna pacos) MEDIANTE COMPUESTOS BIODEGRADABLE Y CARBONATO DE CALCIO." Revista Recursos Naturales Producción y Sostenibilidad 3, no. 1 (2024): 52–68. https://doi.org/10.61236/renpys.v3i1.626.

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El presente estudio llevado a cabo en el Laboratorio de Fibras Agroindustriales y Curtiembre de la Facultad de Ciencias Pecuarias de la Escuela Superior Politécnica de Chimborazo. Se evaluaron los efectos del lavado de la fibra de alpaca con distintas concentraciones de bicarbonato de sodio, en combinación con detergente biodegradable. Se emplearon 16 unidades experimentales, cada una con 200 g de fibra, distribuidas en cuatro tratamientos replicados cuatro veces. Se aplicó un Diseño Completamente al Azar para el análisis de resultados, utilizando estadísticas descriptivas, análisis de varianz

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Warmansyah, Jhoni, Afriyane Ismandela, Dinda Fatma Nabila, et al. "Smartphone Addiction, Executive Function, and Mother-Child Relationships in Early Childhood Emotion Dysregulation." JPUD - Jurnal Pendidikan Usia Dini 17, no. 2 (2023): 241–66. http://dx.doi.org/10.21009/jpud.172.05.

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Early childhood emotional dysregulation is critical in recognizing and preventing psychological well-being disorders, laying the groundwork for developing healthy emotional behaviors early on. This study aims to determine the direct influence of smartphone addiction, executive function, and the mother-child relationship on emotional dysregulation in early childhood in West Sumatra. This research method is a quantitative survey. The data collection technique in this research uses a questionnaire design on 309 parents who were selected using a simple random sampling method. This data processing

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Bashonga, Bishobibiri Alexis, Sande Eric, Ntakimazi Gaspard, and Kahindo Charles. "Bird Ecology in the Ruzizi Delta, Northern End of Lake Tanganyika in Burundi and in the Democratic Republic of Congo." Biolife 11, no. 1 (2023): 12–20. https://doi.org/10.5281/zenodo.7686228.

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<strong>Abstract</strong> Bird ecology in the Ruzizi Delta was investigated during the months of April, July and October 2019-2021. Three species of water birds were the most prominent, the Cattle Egret (Ardeidae), Bubulcus ibis (Linnaeus, 1758) «Héron garde boeufs», the Black Crake (Rallidae) Amaurornis flavirostris (Swainson, 1837) «Râle à bec jaune» and the Africana Jacana (Jacanidae) Actophilornis africanus (Gmelin, 1789) «Jacana a poitrine dorée». The objective pursued by the research is the sustainable conservation of birds b

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Mogwitz, Sabine, Christian Albus, Petra Beschoner, et al. "Mental distress of physicians in the outpatient care throughout the COVID-19 pandemic: emotional and supportive human relations matter – Cross-sectional results of the VOICE-study." BMC Health Services Research 23, no. 1 (2023). http://dx.doi.org/10.1186/s12913-023-09361-3.

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Abstract Background The aim of this cross-sectional study was to evaluate the course of self-reported mental distress and quality of life (QoL) of physicians, working in the outpatient care (POC). Outcomes were compared with a control group of physicians working in the inpatient care (PIC), throughout the Corona Virus Disease (COVID)-19 pandemic. The impact of risk and protective factors in terms of emotional and supportive human relations on mental distress and perceived QoL of POC were of primary interest. Methods Within the largest prospective, multi-center survey on mental health of health

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Thouvenot, Eric, David Laplaud, Christine Lebrun-Frenay, et al. "High-Dose Vitamin D in Clinically Isolated Syndrome Typical of Multiple Sclerosis." JAMA, March 10, 2025. https://doi.org/10.1001/jama.2025.1604.

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ImportanceVitamin D deficiency is a risk factor for multiple sclerosis (MS) and is associated with the risk of disease activity, but data on the benefits of supplementation are conflicting.ObjectiveTo evaluate the efficacy of high-dose cholecalciferol as monotherapy in reducing disease activity in patients with clinically isolated syndrome (CIS) typical for MS.Design, Setting, and ParticipantsThe D-Lay MS trial was a parallel, double-blind, randomized placebo-controlled clinical trial in 36 MS centers in France. Patients were enrolled from July 2013 to December 2020 (final follow-up on January

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Kröger, Nicolaus, Ernst Holler, Guido Kobbe, et al. "Allogeneic stem cell transplantation after reduced-intensity conditioning in patients with myelofibrosis: a prospective, multicenter study of the Chronic Leukemia Working Party of the European Group for Blood and Marrow Transplantation." October 7, 2009. https://doi.org/10.1182/blood-2009-07-234880.

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Abstract From 2002 to 2007, 103 patients with primary myelofibrosis or postessential thrombocythemia and polycythemia vera myelofibrosis and a median age of 55 years (range, 32-68 years) were included in a prospective multicenter phase 2 trial to determine efficacy of a busulfan (10 mg/kg)/fludarabine (180 mg/m2)–based reduced-intensity conditioning regimen followed by allogeneic stem cell transplantation from related (n = 33) or unrelated donors (n = 70). All but 2 patients (2%) showed leukocyte and platelet engraftment after a median of 18 and 22 days, respectively. Acute graft-versus-host d

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Dum, David, Daniela Kromm;, Maximilian Lennartz, et al. "SATB2 Expression in Human Tumors." Archives of Pathology & Laboratory Medicine, August 2, 2022. http://dx.doi.org/10.5858/arpa.2021-0317-oa.

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Context.— Special AT-rich sequence–binding protein 2 (SATB2) induces local chromatin loops to facilitate transcription. SATB2 immunostaining is commonly used as a marker for colorectal adenocarcinoma and osteosarcoma. Objective.— To extend our knowledge on the diagnostic value of SATB2 analysis in a comprehensive set of human tumors. Design.— Tissue microarrays with 15 012 samples from 120 tumor types and 608 samples of 76 different normal tissues were analyzed. Results.— SATB2 positivity was found in 89 of 120 different tumor types (74%), including 59 of 120 (49%) with at least 1 moderately p

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Roth, Romain Samuel, Stavroula Masouridi-Levrat, Yves Chalandon, et al. "Invasive Mold Infections in Allogeneic Hematopoietic Cell Transplant Recipients in 2020: Have We Made Enough Progress?" Open Forum Infectious Diseases 9, no. 1 (2021). http://dx.doi.org/10.1093/ofid/ofab596.

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Abstract Background Despite progress in diagnostic, prevention, and treatment strategies, invasive mold infections (IMIs) remain the leading cause of mortality in allogeneic hematopoietic cell transplant (allo-HCT) recipients. Methods We describe the incidence, risk factors, and mortality of allo-HCT recipients with proven/probable IMI in a retrospective single-center 10-year (01/01/2010–01/01/2020) cohort study. Results Among 515 allo-HCT recipients, 48 (9.3%) patients developed 51 proven/probable IMI: invasive aspergillosis (IA; 34/51, 67%), mucormycosis (9/51, 18%), and other molds (8/51, 1

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dos Santos, Marcelo R., Ana Luiza C. Sayegh, Marco A. Arap, et al. "Abstract 18671: Exercise Training Associated With Testosterone Replacement Decreases Muscle Sympathetic Nerve Activity in Heart Failure Patients With Hypogonadism." Circulation 128, suppl_22 (2013). http://dx.doi.org/10.1161/circ.128.suppl_22.a18671.

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Purpose: Heart failure (HF) is characterized by increase in muscle sympathetic nerve activity (MSNA). Advanced HF can be associated to testosterone deficiency. Study with HF patients and testosterone therapy showed improvement in VO2 and baroreflex sensitivity. The role of exercise with or without testosterone is unknown. Therefore, the aim of the study was to investigate if aerobic exercise with or without testosterone replacement decreases MSNA. Methods: 24 HF patients (52±2 yr) with low testosterone, FC III (NYHA) and LVEF 26±2%, were divided: Exercise Training (ET,n=9) Testosterone (Testo,

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Buck, Catherine O., Veronika Shabanova, Reese H. Clark, and Sarah N. Taylor. "Diabetes in Pregnancy, Neonatal Morbidities, and Early Growth in Moderate or Late Preterm Infants." Pediatrics, November 16, 2023. http://dx.doi.org/10.1542/peds.2023-061285.

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OBJECTIVES: To compare differences in short term morbidities and early growth among moderate and late preterm infants of mothers with and without diabetes (DM) in pregnancy. METHODS: In a longitudinal analysis using data from the Pediatrix Clinical Data Warehouse of preterm infants (born 32 0/7 to 36 6/7 weeks) discharged from neonatal intensive care units from 2008 to 2019, health characteristics were compared between DM exposure groups. Change in growth from birth to discharge were compared using linear mixed effects modeling. RESULTS: Among 301 499 moderate and late preterm infants in the a

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Aengevaeren, V., A. Mosterd, TL Braber, et al. "Exercise intensity is associated with progression of coronary artery calcification in middle-aged and older athletes: findings from the MARC-2 study." European Journal of Preventive Cardiology 28, Supplement_1 (2021). http://dx.doi.org/10.1093/eurjpc/zwab061.369.

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Abstract Funding Acknowledgements Type of funding sources: Foundation. Main funding source(s): Dutch Heart Foundation Background Recent studies have reported increased coronary artery calcification (CAC) in middle-aged male athletes, which is related to the amount and intensity of lifelong exercise. However, previous studies are limited by their cross-sectional study design. Purpose We prospectively assessed progression of CAC and its association to exercise volume and intensity in middle-aged and older athletes. Methods 318 asymptomatic middle-aged and older men were recruited in the Measurin

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Kazantsev, Anton N., Alexander V. Korotkikh, Showen Wang, et al. "Carotid endarterectomy for symptomic and asymptomic stenosis: Report of 65388 cases (Russian register)." Vascular, June 7, 2024. http://dx.doi.org/10.1177/17085381241259928.

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Aim Analysis of in-hospital and long-term results of carotid endarterectomy in patients with asymptomatic and symptomatic stenoses. Materials and methods The sample was formed by completely including all cases of carotid endarterectomy ( n = 65,388) performed during the period from May 1, 2015 to November 1, 2023. Depending on the symptomatic/asymptomatic nature of the stenosis, all patients were divided into two groups: group 1 – n = 39,172 (75.2%) – patients with asymptomatic stenosis; Group 2 – n = 26216 (24.8%) – patients with symptomatic stenosis. The postoperative follow-up period was 53

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Du, Mengxi, and Fang Fang Zhang. "Dietary Supplement Use Among Adult Cancer Survivors in the United States." FASEB Journal 31, S1 (2017). http://dx.doi.org/10.1096/fasebj.31.1_supplement.168.6.

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BackgroundMany cancer patients initiated supplement use after cancer diagnosis and yet the effect of supplement use on survival has not been established. The trend of and factors associated with dietary supplement use in cancer survivors warrant further investigation.MethodsWe examined the trend of dietary supplemental use in 1,902 adult cancer survivors who participated in the National Health and Nutrition Examination Survey (NHANES) from 1999 to 2012, and compared the frequency of supplement use in cancer survivors to that of 3,804 individuals with no history of cancer who were matched to th

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Victor, Ronald G., Ning Li, O’Neil Mason, Kathleen Lynch, Mohamad Rashid, and Robert Elashoff. "Abstract 090: Nocturia as an Unrecognized Symptom of Uncontrolled Hypertension in Middle-age Black Men." Hypertension 70, suppl_1 (2017). http://dx.doi.org/10.1161/hyp.70.suppl_1.090.

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Hypertension (HTN) is assumed to be asymptomatic (“the silent killer”). Yet nocturia - awakening at night to urinate - is bothersome if occurring > 2 times/night and constitutes a putative but understudied symptom of HTN. Hypertensive black men may be especially prone to nocturia due to high sodium diet, blunted nocturnal blood pressure (BP) dipping (driving pressure-natriuresis), diuretic BP drugs, and common comorbid determinants of nocturia (prostate disease, diabetes, sleep apnea). To test if uncontrolled HTN is an independent, common, and potentially reversible determinant of nocturia

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GHOLAMI, MARYAM, NICHOLAS JACKSON, TAMRA B. LOEB, et al. "744-P: Reach and Effectiveness of the University of California Diabetes Prevention Program Initiative." Diabetes 72, Supplement_1 (2023). http://dx.doi.org/10.2337/db23-744-p.

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The University of California (UC) system implemented the Diabetes Prevention Program (DPP) across UC campuses to address diabetes and obesity risk. We examined the reach and effectiveness of this novel, university-based DPP delivery approach. We compared weight change at 12-mo follow-up among 3 groups of overweight/obese UC beneficiaries: 1) those who reported receiving DPP invitation letters and enrolled in DPP (DPP enrollees), 2) those who were sent DPP invitation letters but did not enroll (DPP aware non-enrollees), and those who were not sent letters and did not enroll (controls). Using EH

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Moustafa, Muhamad. "A Comprehensive Review of Monoclonal Antibodies for the Treatment of Follicular Lymphoma Including Both Approved and Investigational Options." Medical Research Archives 11, no. 11 (2023). http://dx.doi.org/10.18103/mra.v11i11.4745.

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Follicular lymphoma (FL) is the most common type of indolent lymphoma in the Western world, accounting for approximately 30% of lymphoma cases. FL is known for its recurrent nature, necessitating diverse treatment options. The introduction of rituximab, an anti-CD20 antibody, has greatly improved FL outcomes and paved the way for targeted therapies. In this review, we thoroughly explore the structure, mechanism of action, clinical outcomes, and side effects of currently approved monoclonal antibodies (mAb) for FL. Furthermore, we provide insights into ongoing clinical trials and emerging monoc

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