To see the other types of publications on this topic, follow the link: 32 factorial designs.
Journal articles on the topic '32 factorial designs'
Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles
Consult the top 50 journal articles for your research on the topic '32 factorial designs.'
Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.
You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.
Browse journal articles on a wide variety of disciplines and organise your bibliography correctly.
1
Conagin, Armando, and Luís Alberto Ambrósio. "FRACTIONAL FACTORIAL DESIGNS 1/32 (45) IN BLOCKS OF SIXTEEN UNITS." BRAZILIAN JOURNAL OF AGRICULTURE - Revista de Agricultura 82, no. 2 (2015): 142. http://dx.doi.org/10.37856/bja.v82i2.1445.
Full text
2
Boguslavsky, Ilya, Slava Z. Brodsky, and Gena R. Ioffe. "Regular uniform main-effect designs derivable from geometric factorial designs in 2n runs." Model Assisted Statistics and Applications 15, no. 4 (2020): 323–33. http://dx.doi.org/10.3233/mas-200504.
Full textAbstract:
The article introduces a general method of construction of asymmetrical regular factorial main-effect designs in 2n runs. It presents a collection of optimal designs constructed by this method in 32, 64, 128, and 256 runs. The method provides exploration of design structure and construction of designs with required properties. Construction of composite designs is given as an example of design structure exploration.
3
Kaur, Gunjeet, Goutam Rath, Hemraj Heer, and Amit K. Goyal. "Optimization of Protocell of Silica Nanoparticles Using 32 Factorial Designs." AAPS PharmSciTech 13, no. 1 (2011): 167–73. http://dx.doi.org/10.1208/s12249-011-9741-8.
Full text
4
Essery, R. "A factorial snowpack model (FSM 1.0)." Geoscientific Model Development 8, no. 12 (2015): 3867–76. http://dx.doi.org/10.5194/gmd-8-3867-2015.
Full textAbstract:
Abstract. A model for the coupled mass and energy balances of snow on the ground requires representations of absorption of solar radiation by snow, heat conduction in snow, compaction of snow, transfer of heat to snow from the air and retention and refreezing of meltwater in snow. Many such models exist, but it has proven hard to relate their relative performances to the complexity of their process representations. This paper describes the systematic development of an open-source snowpack model with two levels of representation for each of the five processes mentioned above, allowing factorial experimental designs with 32 different model configurations. The model is demonstrated using driving and evaluation data recorded over one winter at an alpine site.
5
Essery, R. "A Factorial Snowpack Model (FSM 1.0)." Geoscientific Model Development Discussions 8, no. 8 (2015): 6583–609. http://dx.doi.org/10.5194/gmdd-8-6583-2015.
Full textAbstract:
Abstract. A model for the coupled mass and energy balances of snow on the ground requires representations of absorption of solar radiation by snow, heat conduction in snow, compaction of snow, transfer of heat to snow from the air, and retention and refreezing of meltwater in snow. Many such models exist, but it has proven hard to relate their relative performances to the complexity of their process representations. This paper describes the systematic development of an open-source snowpack model with two levels of representation for each of the five processes mentioned above, allowing factorial experimental designs with 32 different model configurations. The model is demonstrated using driving and evaluation data recorded over one winter at an alpine site.
6
K R, Shankar, Aminabee S, Ramana G, Lakshmi KNVC, and Indusree G. "Formulation and Evaluation of Propranolol Hydrochloride Floating Tablets by 32 Factorial Design." INTERNATIONAL JOURNAL OF DRUG DELIVERY TECHNOLOGY 14, no. 04 (2024): 1716–21. https://doi.org/10.25258/ijddt.14.4.17.
Full textAbstract:
The goal of current work is to develop Propranolol HCl floating tablets. Floating tablets of Propranolol HCl were designed basing on the idea of gas generation. Using sodium bicarbonate (NaHCO3) as a gas-generating agent, xanthan gum, polyox WSR 303a as a matrix-forming polymer, and HPMC K4 M and K15 M as matrix-forming polymers, matrix tablets totalling 40 mg of propranolol HCl were created.Among the four polymers namely HPMCK4M, HPMCK15M, Xanthan gum and Polyox WSR, HPMC K4M gave good release and was selected for formulation of propranolol HCl floating tablets by 32 factorial design. Propranolol HCl release from the manufactured floating tablets occurred gradually over the course of 12 hours and was contingent upon the tablet's composition. The percentage that the independent variables HPMC K4M and NaHCO3 were utilised in the formulation of propranolol HCl floating tablets is described by a chosen three level, two factors experimental designs (32 factorial designs). Floating lag time (FLT), percent drug released in 8h were selected as dependent variables. The equations for Floating lag time (FLT) and drug release in 8 hr in (PD8) drug dissolved are as follows. Y1= 23.89 +4.17X1 -8.33 X2-0.75X1X2 +0.17X12 +2.67X22 (FLT), Y2= 81.06 -1.86X1 -4.10X2 -0.14 X1X2 – 0.21X12 + 6.57 X22 (DR8h). The Y1 equations' co-efficient of X2, which has a negative sign, shows that floating lag time increases as sodium bicarbonate concentration falls. The findings indicatethat the amount of NaHCO3 (X2) and the amount of HPMCK4M (X1) both have an impact on how long it takes for a medication to release and floating lag time.All manufactured floating tablet drug release followed first order kinetics, with the exception of F7, F8, and F9. Drug release from all the floating tablets prepared followed first order kinetics except in case of F7, F8 and F9. All manufactured floating tablets had their drug release regulated by non-Fickian diffusion, which served as the floating tablet's release mechanism. For FLT and DR 8h, the proximity between the predicted and observed values supports the rationality of the consequent equations for the dependent variables. Among the nine formulations F9 formulation is considered as best formulation basing on floating lag time and medication release parameters. It can be inferred from the findings that the floating tablets of propranolol HCl can be obtained successfully using optimization by 32 factorial design using HPMC K4M and sodium bicarbonate.
7
Dev, Asish, Nihar Lohagaonkar, and Mansi Deshmukh. "Formulation and Evaluation of Floating Bioadhesive Tablet of Candesartan Cilexetil Using 32 Factorial Designs." International Journal of Research and Review 8, no. 10 (2021): 93–104. http://dx.doi.org/10.52403/ijrr.20211014.
Full textAbstract:
Objective: The objective of the work is to formulate candesartan cilexetil floating bioadhesive tablets which can considerably improve the bioavailability of medicine underneath the condition of redoubled continuance of drug in abdomen. Methods: Floating bioadhesive tablet was ready by direct compression of chemical compound like HPMCE15 and Carbopol934p together. Result: After analysis of different evaluation parameter and drug release, F4 batch was selected as promising formulation for delivery of candesartan cilexetil floating bioadhesive tablets with 91.22% drug release at 12th h. Conclusion: Among the further batches, the F4 batch was selected as an optimized batch as a result of the pre-compression and post-compression parameters results area unit satisfactory. Keywords: Candesartan cilexetil, Floating bioadhesive tablets, Polymer, Total floating time.
8
Young, J. C. "A CATALOG OF CONFOUNDING SCHEMES FOR 8-, 16-, AND 32-RUN FRACTIONAL FACTORIAL DESIGNS." Quality Engineering 9, no. 3 (1997): 433–39. http://dx.doi.org/10.1080/08982119708919062.
Full text
9
Sapate, K. A., P. V. Dangre, and M. D. Godbole. "FORMULATION AND STATISTICAL OPTIMIZATION OF MULTIPARTICULATE LAFUTIDINE-LOADED GASTRORETENTIVE DELIVERY SYSTEM USING 32- FACTORIAL DESIGN." INDIAN DRUGS 51, no. 10 (2014): 43–54. http://dx.doi.org/10.53879/id.51.10.10169.
Full textAbstract:
The purpose of this research was to develop and optimize buoyant beads containing lafutidine by ionic-gelation method for gastroretentive delivery. The effect of two independent process variables like NaHCO 3: Polymer, Drug: Polymer ratio on % drug entrapment, % swelling and % drug release of buoyant beads containing lafutidine was optimized using 32 factorial designs. The observed responses coincided well with the predicted values, given by the optimization technique. The optimized beads showed drug entrapment efficiency 78.76+0.27%, swelling 69.90+0.13%, cumulative drug release 69.00+0.36% after 8 h; the average size of all buoyant beads ranged from 1.35+0.01 to 1.56+0.05 mm. The buoyant beads were characterized by SEM, DSC and FTIR spectroscopy for surface morphology and excipient-drug interaction analysis, respectively. All these beads showed prolong release of lafutidine over 8 h in 0.1 N HCl (pH1.2) evaluation of buoyancy of the optimized formulation in vivo in human volunteers showed that the beads were buoyant in gastric fluid for 8 h both in fasted and fed state.
10
Ramana Kumari Avirneni and Prakash Nathaniel Kumar Sarella. "Exploration of melt granulation technique for the development of entecavir monohydrate tablets using 32 factorial designs." World Journal of Biology Pharmacy and Health Sciences 14, no. 1 (2023): 176–89. http://dx.doi.org/10.30574/wjbphs.2023.14.1.0191.
Full textAbstract:
This research work aims to fabricate fast-release tablets of entecavir monohydrate using a novel melt granulation technique and optimize the proportion of xylitol and mannitol using a 32 factorial design. entecavir monohydrate, a medication used for treating hepatitis B virus (HBV) infection, was used as a model drug. The fast-release tablets were designed to avoid fluctuations in plasma drug concentration and increase the bioavailability of entecavir monohydrate. The FTIR spectra of pure entecavir monohydrate were compared against polymers which had no interaction. The pre-compression and post-compression parameters were found to be within the desired range. The results of the drug release studies indicate that the formulations were able to release the drug within the desired range of 60-80% within 10 minutes. The study concludes that the melt granulation technique can be used to develop fast-release tablets of entecavir monohydrate with good compressibility, flow characteristics, and mechanical strength.
11
Ramana, Kumari Avirneni, and Nathaniel Kumar Sarella Prakash. "Exploration of melt granulation technique for the development of entecavir monohydrate tablets using 32 factorial designs." World Journal of Biology Pharmacy and Health Sciences 14, no. 1 (2023): 176–89. https://doi.org/10.5281/zenodo.8037641.
Full textAbstract:
This research work aims to fabricate fast-release tablets of entecavir monohydrate using a novel melt granulation technique and optimize the proportion of xylitol and mannitol using a 3<sup>2</sup> factorial design. entecavir monohydrate, a medication used for treating hepatitis B virus (HBV) infection, was used as a model drug. The fast-release tablets were designed to avoid fluctuations in plasma drug concentration and increase the bioavailability of entecavir monohydrate. The FTIR spectra of pure entecavir monohydrate were compared against polymers which had no interaction. The pre-compression and post-compression parameters were found to be within the desired range. The results of the drug release studies indicate that the formulations were able to release the drug within the desired range of 60-80% within 10 minutes. The study concludes that the melt granulation technique can be used to develop fast-release tablets of entecavir monohydrate with good compressibility, flow characteristics, and mechanical strength.
12
Boi, Basanta Kumar Reddy, Sahoo Nityananda, Prasad Padhy Rama, et al. "OPTIMIZATION OF AN ANTIDEPRESSANT DRUG LOADED SOLID LIPID NANOPARTICLES BY HOT HOMOGENIZATION TECHNIQUE WITH 32 FACTORIAL DESIGNS." COMMUNİTY PRACTİTİONER 20, no. 08 (2023): 254–65. https://doi.org/10.5281/zenodo.8285818.
Full textAbstract:
<strong>Abstract</strong> A revolutionary type of colloidal pharmaceutical delivery system has been invented, and in comparison, to the conventional dosage forms, it provides a number of benefits that cannot be found with the other options. Solid lipid nanoparticles, also known as SLN, offer a number of benefits, one of which is the ability to administer medications in a controlled and location-specific manner because to their utilisation. It is made up of a solid core and possesses a substantial drug content in its phospholipid cover up both of which contribute to boost its bioavailability. Additionally, the shell contains phospholipids. It is estimated that more than 200 million people around the world are afflicted with depression, which makes it the most widespread form of mental and emotional illness in the world. The symptoms of this illness include reduced concentration, a depressed mood, a loss of excitement in things that were previously enjoyable, feelings of shame or inadequate worth, disruptions in sleep or eating, and an inability to focus. Antidepressant drug containing sertraline monohydrate has the ability to target particular regions of the brain. To look into the impact which the formulation of those solid lipid nanoparticles possessed, in addition to the impact that the process variables had, on the efficacy of such established solid lipid nanoparticles was the primary objective of this work. Additionally, the formulation of strong lipid nanoparticles which were loaded with sertraline hydrochloride was one of the process variables that was investigated. In order to manufacture the solid lipid nanoparticles, a hot homogenization method was used, and 3<sup>2</sup> distinct factorial designs were incorporated into the research. In this study, the effects of various independent parameters on the amount of poloxamer 188 and glyceryl monosterate, as well as the effects of these factors on viscosity and drug release, were investigated. In order to evaluate the efficacy of the SLNs that were manufactured, they were loaded with sertraline hydrochloride. According to the data, the formulation known as SNF6 was the one that was the most successful. It had an entire entrapment efficiency of 91.32 ±2.35% and a drug release of 89.45 ±2.35% respectively. Enrichment of sertraline was accomplished by HCl entrapment, resulting in an adequate particle size and controlled release, as a direct result of the exhaustive screening inquiry. The factorial design was able to illustrate either the significance of it and it influence in determining and grasping the formulation and execution of the factors that influence the quality of SLNs. This was accomplished via the use of factorial arrangements.
13
Wang, Bo, Robert G. McLeod, and John F. Brewster. "A note on the selection of optimal foldover plans for 16- and 32-run fractional factorial designs." Journal of Statistical Planning and Inference 140, no. 6 (2010): 1497–500. http://dx.doi.org/10.1016/j.jspi.2009.12.011.
Full text
14
Dorwal, Dhawal, and Ravikant Gupta. "Formulation and Characterization of Novel Floating Raft Forming In-situ Gel for Delivery of BCS Class II Drugs." Journal of Neonatal Surgery 14, no. 4S (2025): 1133–50. https://doi.org/10.52783/jns.v14.1924.
Full textAbstract:
The main objective of the research was to formulate an oral raft-forming in situ gelling system of Albendazole (ABZ) to improve gastric retention and drug release in a controlled manner and remain floating in the stomach for a prolonged time. In this study in situ gelling system was developed and optimized by a two-factor at three-level (32) factorial design. It was analyzed to study the impact of two independent variables vizGellan gum [A] and Carbapol 934 P [B] on the responses, such as floating lag time, percentage (%) water uptake at 2 h, and % drug release at 6 h and 12 h. An in vitro gelation study of the in situ gel formulation showed immediate gelation and was retained for a longer period. From the obtained results of 32 factorial designs, it was observed that all the selected factors had a significant effect on the chosen response, supporting the precision of design employed for optimization. Thus, the developed oral raft-forming in situ gelling system of ABZ can be a promising and alternate approach to enhance retention in the stomach and to attain sustained release of drug by floating, thereby augmenting the therapeutic efficacy of ABZ.
15
Kasar, Harshada Anil, Asish Dev, and Subhakanta Dhal. "FORMULATION AND EVALUATION OF LIDOCAINE HYDROCHLORIDE CHEWABLE TABLET." Asian Journal of Pharmaceutical and Clinical Research 11, no. 11 (2018): 190. http://dx.doi.org/10.22159/ajpcr.2018.v11i11.27057.
Full textAbstract:
Objective: The objective of this study was to formulate and optimize a chewable formulation of lidocaine hydrochloride using a 32 factorial design for optimized the superdisintegrant concentration.Methods: Various concentrations of sodium starch glycolate (SSG) (13.33 mg, 26.66 mg, and 40 mg) of superdisintegrant and starch (50 mg, 83 mg, and 116.66 mg) were added in the formulation; nine formulations were prepared according to 32 factorial designs and evaluated. The responses were analyzed for analysis of variance using Design-Expert version 10 software. Statistical models were generated for each response parameter. The models were tested for significance. Procedure to manufacture chewable tablets by direct compression was established.Results: The results show that the presence of a superdisintegrant is desirable for chewable formulation. The best-optimized batch F7 found the batch having starch of amount 116.66 mg and SSG 13.33 mg. All the prepared batches of tablets were within the range. Optimized batch F7 showed drug content 102.46±0.0543, wetting time 18±1.7320, friability 0.65±0.0216, and drug release rate 99.97±0.0124% at the end of 30 min.Conclusion: It can be concluded that 32 full factorial design and statistical models can be successfully used to optimize the formulations, and it was concluded that the trial batch F7 is the optimized formulation which compiles official specifications of chewable tablets. The optimized batch was evaluated for thickness, weight variation, hardness, friability, drug dissolution, and stability study for 3 months. The similarity factor was calculated for comparison of dissolution profile before and after stability studies. After 30 min the drug release rate for batch F7 was 98.97% (Table 6). Hence, the results of stability studies reveal that the developed formulation has good stability.
16
Martínez, M. L., M. G. Bordón, R. M. Bodoira, M. C. Penci, P. D. Ribotta, and D. M. Maestri. "Walnut and almond oil screw-press extraction at industrial scale: Effects of process parameters on oil yield and quality." Grasas y Aceites 68, no. 4 (2018): 216. http://dx.doi.org/10.3989/gya.0554171.
Full textAbstract:
Walnut and almond kernels are highly nutritious mainly due to their high oil contents. In this study, 32 factorial experimental designs were used to optimize processes for oil extraction by screw-pressing at industrial scale. Experimental designs included seed moisture content (SMC), and restriction die (RD) as the main processing parameters. Theoretical models were scanned against experimental data in order to optimize oil extraction conditions. The response variables analyzed were oil yield (OY), fine solid content (FC) in oil, and oil quality parameters. Fitted models for OY indicated maximum predicted values similar to the highest experimental values. Walnut oil extractions showed a maximum OY (84.5 ± 2.3 %) at 7.21% SMC, and 10 mm RD. For almond kernels, maximum OY (71.9 ± 3.5%) was obtained at 9.42% SMC, and 12 mm RD. Chemical quality parameters from both oils were in the ranges stated in Codex (FAO/WHO) standards for virgin (non-refined) oils.
17
Nair, Anroop, Jigar Shah, Bandar Al-Dhubiab, et al. "Clarithromycin Solid Lipid Nanoparticles for Topical Ocular Therapy: Optimization, Evaluation and In Vivo Studies." Pharmaceutics 13, no. 4 (2021): 523. http://dx.doi.org/10.3390/pharmaceutics13040523.
Full textAbstract:
Solid lipid nanoparticles (SLNs) are being extensively exploited as topical ocular carrier systems to enhance the bioavailability of drugs. This study investigated the prospects of drug-loaded SLNs to increase the ocular permeation and improve the therapeutic potential of clarithromycin in topical ocular therapy. SLNs were formulated by high-speed stirring and the ultra-sonication method. Solubility studies were carried out to select stearic acid as lipid former, Tween 80 as surfactant, and Transcutol P as cosurfactant. Clarithromycin-loaded SLN were optimized by fractional factorial screening and 32 full factorial designs. Optimized SLNs (CL10) were evaluated for stability, morphology, permeation, irritation, and ocular pharmacokinetics in rabbits. Fractional factorial screening design signifies that the sonication time and amount of lipid affect the SLN formulation. A 32 full factorial design established that both factors had significant influences on particle size, percent entrapment efficiency, and percent drug loading of SLNs. The release profile of SLNs (CL9) showed ~80% drug release in 8 h and followed Weibull model kinetics. Optimized SLNs (CL10) showed significantly higher permeation (30.45 μg/cm2/h; p < 0.0001) as compared to control (solution). CL10 showed spherical shape and good stability and was found non-irritant for ocular administration. Pharmacokinetics data demonstrated significant improvement of clarithromycin bioavailability (p < 0.0001) from CL10, as evidenced by a 150% increase in Cmax (~1066 ng/mL) and a 2.8-fold improvement in AUC (5736 ng h/mL) (p < 0.0001) as compared to control solution (Cmax; 655 ng/mL and AUC; 2067 ng h/mL). In summary, the data observed here demonstrate the potential of developed SLNs to improve the ocular permeation and enhance the therapeutic potential of clarithromycin, and hence could be a viable drug delivery approach to treat endophthalmitis.
18
El-Ghwas, Dina E., Tarek E. Mazeed, Amr El-Waseif, Hind A. Al-Zahrani, Omar A. Almaghrabi, and Ahmed M. Elazzazy. "Factorial Experimental Design for Optimization of Zinc Oxide Nanoparticles Production." Current Nanoscience 16, no. 1 (2020): 51–61. http://dx.doi.org/10.2174/1573413715666190618103127.
Full textAbstract:
Background: Biosynthetic nanomaterials have recently received increasing attention because they are non-toxic, clean, environmentally acceptable, safe, and biocompatible. Objective: In the present study, cell-free culture filtrate of Aspergillus sp. was used for extracellular synthesis of zinc oxide (ZnO) nanoparticles. Method: Plackett-Burman and Taguchi designs were implemented to optimize conditions for maximum ZnO nanoparticle production. In the Plackett-Burman design, 15 factors, representing different carbon and nitrogen sources, were studied. For the Taguchi design, an L-27 (313) standard orthogonal array was constructed to examine nine factors. Results: The maximum yield of ZnO nanoparticles of 21.73 g/L was achieved with 1.0 mM ZnSO4 under optimal conditions of peptone extract (20 g/L), yeast extract (10 g/L), meat extract (10 g/L), K2HPO4 (0.25 g/L), FeSO4⋅7H2O (0.002 g/L), NaCl (2.5 g/L), pH 6, 32°C, and a 200-mL volume. The ZnO nanoparticles’ production was confirmed by the formation of white aggregates. The UV absorption spectrum showed one peak at 376 nm, which also confirmed the formation of nanoparticles. Transmission electron microscopy revealed that the nanoparticles were large rods of 11.6-43.97 nm diameter, and 355.91 nm length. Importantly, the ZnO nanoparticles exhibited broad antimicrobial activity against gram-positive and gram-negative bacteria and a unicellular fungus. Conclusion: The concentrations of ZnSO4 ions, ferrous ions, and peptone and meat extracts, and the interactions between them, were observed to be the main parameters influencing ZnO nanoparticles’ yield.
19
Ruiz-Domínguez, Mari Carmen, Juan Luis Fuentes, Jose A. Mendiola, Juan Morales, Carlos Vílchez, and Elena Ibanez. "Bioprospecting of cyanobacterium in Chilean coastal desert, Geitlerinema sp. Molecular identification and Pressurized Liquid Extraction of bioactive compounds." Bioproducts Processing 128 (June 11, 2021): 227–39. https://doi.org/10.5281/zenodo.14770259.
Full textAbstract:
This study presents a new cyanobacterium of the genus Geitlerinema sp. isolated from theChilean coastal desert as a rich source of bioactive compounds. Phylogenetic tree is shownalong with a broad biochemical characterization using conventional and pressurized liq-uid extraction. Variables as extraction yield, phycobiliproteins, lipids and methyl palmitate(C16:0) were studied by means of two experimental designs based on a response surfacemethodology (RSM) employing two factorial design 32. Factors as temperature (20–200◦C)and percentage of solvents were selected resulting in Factorial Design A with 0–100% (v/v)of ethanol–water and Factorial Design B with 0–100 (v/v) of ethanol–limonene solvents.The main bioactive compounds were total proteins (∼52% wt), phycobiliproteins (espe-cially C-phycocyanin) and methyl palmitate (C16:0). Data obtained showed that water andethanol:water (1:1, v/v) improved the extraction yield and phycobiliproteins recovery. Asfor ethanol:limonene extracts, they were better for lipids and methyl palmitate extractions.In general, high temperatures only improved the extraction yield whereas low tempera-tures favor the extraction of phycobiliproteins. Therefore, results indicated that Geitlerinemasp. could be one of the several cyanobacteria genera that display functional properties fornutritional, pharmaceutical or industrial use as sustainable and cost-effective bioactivecompounds in algal biorefinery model.
20
Patel, Afroza Akbar, Siraj N. Shaikh, Huzaifa Patel, Afzal Band, and Ahmed Shaoor. "Designing fabrication and evaluation of Oral fast Disintegrating tablet of Ranitidine HCL." Journal of Drug Delivery and Therapeutics 9, no. 1 (2019): 95–102. http://dx.doi.org/10.22270/jddt.v9i1.2176.
Full textAbstract:
The aim of this research work was to design develop & evaluate oral fast disintegrating tablets of Ranitidine HCL. The Orodispersible tablets of Ranitidine HCl were prepared by using direct Compression technique with a Synthetic Superdisintegrant such as Crosspovidone and a natural Superdisintegrant Fenugreek gum in different concentration. 32 factorial designs was applied to study the effect of independent variables, concentration of Crosspovidone & Fenugreek gum on dependent variables like Cumulative % Drug release and Disintegration time by using design expert software. Prepared oral fast disintegrating tablets evaluated for Pre and Post-compression parameters. The prepared tablets exhibited satisfactory physico-chemical characterise especially fast disintegration & dissolution property. Full factorial design and optimization technique successfully used in the development oral fast disintegrating tablets. Comparing the all the formulations, formulation F9 was considered as optimized formulation which shows excellent fast disintegration, in vitro dissolution, and faster drug release within 6 min in comparison to other batches also stable in stability study.
 Keywords: Fast disintegrating, Ranitidine, Crosspovidone, Gum, Optimizations, Water absorption ratio
21
A-A Khammas, Zuhair. "Extraction and Determination of Sildenafil Citrate by Spectrophotometry: Classical Versus Factorial Design Optimization." Tikrit Journal of Pharmaceutical Sciences 9, no. 1 (2023): 61–79. http://dx.doi.org/10.25130/tjphs.2013.9.1.7.61.79.
Full textAbstract:
In this work, the complexation and extraction processes of sildenafil citrate (SC) were evaluated by using classical optimization versus factorial design methodology. The selected factors were based on the reaction of sildenafil with methyl orange (MO) as a chromogenic reagent via the formation of ion-association complex in acidic buffer media, followed by extraction with chloroform and quantitatively measured by visible spectrophotometry at λmax of 427 nm. The optimization step was first carried out by classical one-factor-at-a-time (OFAT) from which the extracted results were exploited in the experimental design optimization by using 24-1 fractional factorial and 32 full factorial designs for the chosen variables such as pH, concentration of reagent, reaction time, extraction time and temperature. Results obtained from fractional factorial design 24-1 showed that only the variables pH, MO concentration and their interaction based on analysis of variance (ANOVA) in term of Pareto chart, were statistically significant at 95% confidence level. Under the optimized conditions, the assay method of SC was validated in term of the analytical figures of merit. SC can be determined in concentration range of 0.5-40 µg mL-1 with correlation coefficient of 0.9991, detection limit (S/N) of 0.15 µg mL-1, RSD (n=10) of 1.43%, accuracy as %Erel of -2.23% and mean percent recovery of 97.77±0.87. The proposed method was applied for the determination of SC in commercial medicaments without fear from excipients interferences with the assay procedure.
22
Green, Sophie M. C., and Samuel G. Smith. "Dataset for a randomised factorial experiment to optimise an information leaflet for women with breast cancer." NIHR Open Research 4 (May 30, 2024): 32. http://dx.doi.org/10.3310/nihropenres.13547.1.
Full textAbstract:
Background Adherence to adjuvant endocrine therapy (AET) is low in women with breast cancer, which increases the risk of recurrence and mortality. A consistently reported barrier to adherence is low perceived necessity of AET and high concerns. Existing interventions to support medication beliefs have mixed effectiveness and rarely target medication beliefs specifically. We developed an information leaflet with five candidate components aiming to increase necessity beliefs about AET and reduce concerns; (1) diagrams explaining how AET works; (2) icon arrays displaying the benefits of AET; (3) information about the prevalence of side-effects; (4) answers to common concerns and (5) quotes and pictures from breast cancer survivors. Guided by the multiphase optimisation strategy (MOST), we aimed to optimise the content of the information leaflet. We planned for the dataset to be open access to provide an exemplar for other investigators to use. Methods The content of the leaflet was optimised in a fully powered online 25 factorial experiment. Each candidate component of the leaflet was operationalised as a factor with two levels; on vs off or enhanced vs basic. Healthy women (n=1604) completed the beliefs about medicines questionnaire and were randomised to view one of 32 versions of the information leaflet. The 32 versions comprised unique combinations of the factor levels corresponding to the five candidate intervention components. Time spent on the information leaflet page of the survey was recorded. After viewing the information leaflet, participants completed the beliefs about medicines questionnaire again, a true/false questionnaire assessing their objective knowledge of AET, a subjective rating of their knowledge of AET, and a questionnaire evaluating their satisfaction with the information they received. Importance of this dataset The factorial dataset provides the opportunity for other investigators interested in using the MOST framework to learn about complex factorial designs, using a real dataset.
23
Hari Hara Nadh, T. V., P. Sivaram Kumar, M. Venkata Ramana, and N. Rama Rao. "Formulation and Optimization of Zolmitriptan Orodispersible Tablets." Journal of Drug Delivery and Therapeutics 11, no. 3 (2021): 50–57. http://dx.doi.org/10.22270/jddt.v11i3.4703.
Full textAbstract:
Zolmitriptan is a selective 5-hydroxytryptamine receptor agonist reported for the acute migraine treatment, having poor water solubility leads to poor bioavailability. In the present study, attempt to improve the bioavailability of zolmitriptan with the help of PVP K-30 using the microwave irradiation method. The zolmitriptan and PVP K- 30 in 1:1 ratio was subjected to microwave irradiation for different times such as 60,80,100,120 seconds at 650 watts. Characterization of solid dispersion was done by drug content, XRD, FTIR, DSC. FTIR analysis demonstrated there are no compatibility issues. XRD studies prove that the solid dispersion was in amorphous form. DSC studies prove that solid dispersion was amorphous based on the intensity of peaks. The prepared dispersion was made into orodispersible tablets by direct compression. The optimization of these formulations was carried out by using 32 factorial designs on Design Expert 10.0 software. In order to examine the effect of independent variables Crospovidone (X1), croscarmellose sodium (X2), and combined effect of independent variables 32 factorial design was selected. In this design, two responses such as disintegration time and % drug release were evaluated, and experimental trials are performed for all 9 formulations. For all formulations, the precompression and post-compression parameters were studied. Based upon the model optimized formulation (C1 and C2) was obtained having the disintegration time (34.4±0.84 and 39.8±0.91) and %drug release (98.7±0.42 and 93.2±0.46) respectively.
 Keywords: Zolmitriptan, Solid dispersion, Microwave irradiation, Crospovidone, Croscarmellose sodium.
24
Stopher, Peter R., and David A. Hensher. "Are More Profiles Better Than Fewer?: Searching for Parsimony and Relevance in Stated Choice Experiments." Transportation Research Record: Journal of the Transportation Research Board 1719, no. 1 (2000): 165–74. http://dx.doi.org/10.3141/1719-22.
Full textAbstract:
Transportation planners increasingly include a stated choice (SC) experiment as part of the armory of empirical sources of information on how individuals respond to current and potential travel contexts. The accumulated experience with SC data has been heavily conditioned on analyst prejudices about the acceptable complexity of the data collection instrument, especially the number of profiles (or treatments) given to each sampled individual (and the number of attributes and alternatives to be processed). It is not uncommon for transport demand modelers to impose stringent limitations on the complexity of an SC experiment. A review of the marketing and transport literature suggests that little is known about the basis for rejecting complex designs or accepting simple designs. Although more complex designs provide the analyst with increasing degrees of freedom in the estimation of models, facilitating nonlinearity in main effects and independent two-way interactions, it is not clear what the overall behavioral gains are in increasing the number of treatments. A complex design is developed as the basis for a stated choice study, producing a fractional factorial of 32 rows. The fraction is then truncated by administering 4, 8, 16, 24, and 32 profiles to a sample of 166 individuals (producing 1, 016 treatments) in Australia and New Zealand faced with the decision to fly (or not to fly) between Australia and New Zealand by either Qantas or Ansett under alternative fare regimes. Statistical comparisons of elasticities (an appropriate behavioral basis for comparisons) suggest that the empirical gains within the context of a linear specification of the utility expression associated with each alternative in a discrete choice model may be quite marginal.
25
Greco, William R., David C. Sutor, John C. Parsons, et al. "Monte Carlo Comparison of Rival Experimental Designs For Two-Agent Combined Action Studies." Canadian Journal of Infectious Diseases 5, suppl a (1994): 51A—59A. http://dx.doi.org/10.1155/1994/101740.
Full textAbstract:
OBJECTIVE: The combined action of two or more chemotherapeutic agents and/or biological agents can be quantitatively described wilh empirical multidimensional concenlration-effect response surface models. This intuitive statistical approach provides a framework for suggesting experimental designs for in vitro. in vivo and possibly clinical experiments of agent combinations. Five rival 32-point experimental designs for in vitro continuous response two-agent combined action studies were compared using Monte Carlo simulation.DESIGN: The designs were: factorial; central composite: one-ray in duplicate; four-ray; and D-optimal.SETTING: Datasets were simulated by generating ideal data with the authors’ flagship two-agent combined action model. which includes six parameters: the control sunrivalEcon=100 (where Econ is the full range of response that can be affected by the drug); median effective concentrations.IC50.1=10.IC50.2= 1 for drug 1 and drug 2, Respectively; slope parameters. m1=- 1. m2=-2 for drug 1 and drug 2. respectively; and the interaction parameter, α=1 or α=5. For each design, for each of four types of error (absolute. relative with 1% coefficient of variation [cv]. relative with 10% cv. and relative with 10% cv plus a noise constant of 1% ofEcon) . for each of two values of the true α (1, 5). 500 Monte Carlo datasets were generated. and then flt via weighted nonlinear regression wilh lhe flagship model.MAIN Results: For the α parameter. for relative error-containing datasets. the D-optimal designs had the smallest variances.CONCLUSION: The counterintuitive D-optimal designs may be useful for studies in which the experimental units are relatively precious. and frugal designs are essential. In addition. it may be fruitful to add the D-optimal design points lo standard experimental designs.
26
Ruane, J. "The importance of family sizes in adult multiple ovulation and embryo transfer (MOET) nucleus breeding schemes in dairy cattle." Animal Science 52, no. 1 (1991): 33–47. http://dx.doi.org/10.1017/s0003356100005663.
Full textAbstract:
ABSTRACTThe importance of family sizes in adult multiple ovulation and embryo transfer (MOET) nucleus schemes with discrete generations of single trait selection was examined using Monte Carlo simulation. Two areas were investigated. Firstly, the number of sons and daughters per dam was varied in schemes using hierarchical mating designs. With four or eight sires and 32 dams selected, increasing the number of sons per dam from one up to four achieved 1 to 8% higher rates of response but at the expense of increased variation in response and 10 to 56% higher rates of inbreeding. With four or eight sires and 16, 32 or 64 dams selected, the number of daughters was set to two, four or eight (with one son per dam in each case). For schemes transferring equal numbers of embryos, responses were lower with two daughters per dam but were fairly similar with four or eight daughters per dam while inbreeding rates increased as fewer sires and dams were selected. Secondly, the effects of variation in family sizes due to biological factors and chance were investigated with eight sires and 32 dams selected and with hierarchical or factorial (two or four sires per dam) mating designs. When all selected cows yielded embryos, changes in family sizes due to differences in sex ratios, in survival rates of embryos to selection and to variation in the number of embryos per donor reduced response by 1 to 4%. However, when 20% or 33% of the superovulated females yielded no embryos, thus requiring the use of genetically inferior replacements, response was reduced by a further 9 to 13%
27
Hani, Umme, Mohamed Rahamathulla, Riyaz Ali M. Osmani, et al. "Development and Characterization of Oral Raft Forming In Situ Gelling System of Neratinib Anticancer Drug Using 32 Factorial Design." Polymers 14, no. 13 (2022): 2520. http://dx.doi.org/10.3390/polym14132520.
Full textAbstract:
Neratinib (NTB) is an irreversible inhibitor of pan-human epidermal growth factor receptor (HER-2) tyrosine kinase and is used in the treatment of breast cancer. It is a poorly aqueous soluble drug and exhibits extremely low oral bioavailability at higher pH, leading to a diminishing of the therapeutic effects in the GIT. The main objective of the research was to formulate an oral raft-forming in situ gelling system of NTB to improve gastric retention and drug release in a controlled manner and remain floating in the stomach for a prolonged time. In this study, NTB solubility was enhanced by polyethylene glycol (PEG)-based solid dispersions (SDs), and an in situ gelling system was developed and optimized by a two-factor at three-level (32) factorial design. It was analyzed to study the impact of two independent variables viz sodium alginate [A] and HPMC K4M [B] on the responses, such as floating lag time, percentage (%) water uptake at 2 h, and % drug release at 6 h and 12 h. Among various SDs prepared using PEG 6000, formulation 1:3 showed the highest drug solubility. FT-IR spectra revealed no interactions between the drug and the polymer. The percentage of drug content in NTB SDs ranged from 96.22 ± 1.67% to 97.70 ± 1.89%. The developed in situ gel formulations exhibited a pH value of approximately 7. An in vitro gelation study of the in situ gel formulation showed immediate gelation and was retained for a longer period. From the obtained results of 32 factorial designs, it was observed that all the selected factors had a significant effect on the chosen response, supporting the precision of design employed for optimization. Thus, the developed oral raft-forming in situ gelling system of NTB can be a promising and alternate approach to enhance retention in the stomach and to attain sustained release of drug by floating, thereby augmenting the therapeutic efficacy of NTB.
28
Ramteke, Kuldeep H., Dipika E. Ghadge, Savita A. Palve, and Sachin S. Gaikwad. "Design, Development and Optimization of Glibenclamide Sustained Release Matrix Tablet by Using Natural Polymers." Current Applied Polymer Science 3, no. 3 (2020): 197–211. http://dx.doi.org/10.2174/2452271603666191104151057.
Full textAbstract:
Background: Tablets being the conventional dosage forms can be modified for providing the desired therapeutic effect to the patients. The network of matrix in the tablet allows the drug release to be slowed down considerably. Objective: The prime objective of the study was to formulate sustained release glibenclamide matrix tablets using locust bean gum and karaya gum as a matrix polymer. Methods: Tablets were formulated by optimization using 32 factorial designs by direct compression method using different drug: polymer concentrations. The dependent variables selected were % cumulative drug release (Y1) and % drug content (Y2). The independent variables are the amount of locust bean gum (X1) and karayagum (X2). Drug-polymer compatibility studies were confirmed by FTIR and DSC. The pre-compression properties of powder were assessed indicating a good flow property. The evaluation results of the tablets were found to be within the Indian Pharmacopoeial limit. In this work, the effect of diluents type and polymer type was studied on the drug release with its increase in concentration. Results: All the formulations showed retarded drug release as the concentration of the polymer was increased. Formulation F8 was selected as the best-optimized formulation with about 100.56% drug release within 12 h. Release kinetics was carried out and it was found to be zero-order release and from assay, drug content was found to be in limits. Conclusion: ANOVA analysis indicated that the studied variables affected the response variables significantly. The optimized formulation was stable. Hence, it is concluded that the Glibenclamide sustained release matrix tablet containing natural polymers were successfully formulated by using 32 factorial design.
29
Jain, Hitesh, Kinjal Patel, Neha Savant, and Umesh Upadhyay. "Optimization of floating bilayered tablets of Ketorolac Tromethamine." Pharmaceutical and Biological Evaluations 4, no. 1 (2017): 14. http://dx.doi.org/10.26510/2394-0859.pbe.2017.03.
Full textAbstract:
Objective: The aim of the present study was to formulate the floating bilayer tablets of Ketorolac tromethamine, first immediate release layer and second sustained release floating layer which would provide initial loading dose of drug and remain in stomach and upper part of GIT for prolonged period of time in a view to maximize solubility of drug which is necessary for its absorption.Methods: The floating bilayered tablets of Ketorolac tromethamine were prepared by using 32 factorial designs by direct compression method. For this, polymers like sodium starch glycolate and polyox WSR 303 were used in various concentrations. Sodium bicarbonate was used as a floating effervescent agent. The formulations were evaluated for hardness, friability, weight variation, swelling index, floating lag time, floating time, % CDR etcResults: From the result obtained, S3 having 23% Polyox WSR 303 and 12% sodium bicarbonate showed better results.Conclusions: The results showed that Polyox WSR is promising tool to designing of sustained release formulation.
30
Lozano-Reátegui, Ronald M., Vitelio Asencios-Tarazona, Fernando P. Taboada-Gutiérrez, et al. "Removal of metals from water of Yarinacocha Lagoon with activated carbon from cocoa pod husks." Revista Brasileira de Engenharia Agrícola e Ambiental 27, no. 2 (2023): 108–13. http://dx.doi.org/10.1590/1807-1929/agriambi.v27n2p108-113.
Full textAbstract:
ABSTRACT The problem addressed is the contamination of the Yarinacocha Lagoon water by heavy metals and poor use of agricultural residues. It was manufactured activated carbon from cocoa (Theobroma cacao L.) pod husks and determined its adsorbent effect in removing polluting metals from the waters of the Yarinacocha Lagoon. The response surface methodology was applied with factorial designs 33 and 32, with three replicates to optimize obtaining the adsorbent and measure its effectiveness in metal removal. The modeling of the pyrolysis process resulted in 17.27 g of activated carbon from 295.72 g of dry pod husks, optimal with the following optimal parameters: 150 °C as activation temperature, 450 °C as carbonization temperature, and 2.5 hours as modification time. This resulted in effective removal of pollutant metals (aluminum: 91.43%, copper: 75%, iron: 58.33% and zinc: 58.33%), from waters samples demonstrating that it is possible to manufacture activated carbon from cocoa pod husks, with an adsorbent potential to remove metals from the waters of the Yarinacocha Lagoon.
31
Alhamhoom, Yahya, Sandip M. Honmane, Umme Hani, et al. "Study of Formulation and Process Variables for Optimization of Piroxicam Nanosuspension Using 32 Factorial Design to Improve Solubility and In Vitro Bioavailability." Polymers 15, no. 3 (2023): 483. http://dx.doi.org/10.3390/polym15030483.
Full textAbstract:
Piroxicam is a Biopharmaceutical Classification System (BCS) Class II drug having poor aqueous solubility and a short half-life. The rationale behind the present research was to develop a Piroxicam nanosuspension to enhance the solubility and thereby the in vitro bioavailability of the drug. Piroxicam nanosuspension (PRX NS) was prepared by an anti-solvent precipitation technique and optimized using a full-factorial design. Herein, the nanosuspension was prepared using polymer polyvinylpyrrolidone (PVP) K30® and Poloxamer 188® as a stabilizer to improve the solubility and in vitro bioavailability of the drug. Nine formulations were prepared based on 32 full-factorial experimental designs to study the effect of the formulation variables such as concentration of poloxamer 188 (%) (X1) and stirring speed (rpm) (X2) as a process variable on the response of particle size (nm) and solubility (µg/mL). The prepared NS was characterized by phase solubility, Fourier-transform infrared (FT-IR), differential scanning calorimetry (DSC), X-ray powder diffraction (XRPD), transmission electron microscopy (TEM), particle size, zeta potential, entrapment efficiency, and percent drug release. DSC and XRPD analysis of freeze-dried NS formulation showed conversion of PRX into a less crystalline form. NS formulations showed a reduction in the size from 443 nm to 228 nm with −22.5 to −30.5 mV zeta potential and % drug entrapment of 89.76 ± 0.76. TEM analysis confirmed the size reduction at the nano level. The solubility was increased from 44 μg/mL to 87 μg/mL by altering the independent variables. The solubility of PRX NS in water was augmented by 14- to 15-fold (87.28 μg/mL) than pure PRX (6.6 μg/mL). The optimized formulation (NS9) at drug-to-stabilizer concentration exhibited a greater drug release of approximately 96.07% after 120 min as compared to the other NS formulations and pure PRX (36.78%). Thus, all these results revealed that the prepared NS formulations have improved the solubility and in vitro dissolution compared to the pure drug. Furthermore, an increase in the drug release was observed from the NS than that of the pure PRX. All these outcomes signified that the prepared PRX NS showed an increase in solubility and in vitro dissolution behavior; which subsequently would aid in attainment of enhanced bioavailability.
32
Yasungnoen, Natthasurang, and Patchanok Srisuradetchai. "Comparison of Model Selection Method Using Data from Classical Designed Experiment." Advanced Materials Research 677 (March 2013): 357–62. http://dx.doi.org/10.4028/www.scientific.net/amr.677.357.
Full textAbstract:
Model selection procedures play important role in many researches especially quantitative research. . In several area of sciences, the analysis and model selection of experiments are often used and often contains two fundamental goals associated with the experimental response of interest which are to determine the best model. The way to address these goals is to implement a model selection procedure. Then, the objectives of this research are to determine whether or not the final models selected are in agreement or differ substantially across the three approaches to model selection: using Akaike’s Information Criterion, using a p-value criterion, and using a stepwise procedure.. Generally, results from these three models are usually compare to each other. All selected models are based on the heredity principle to design the possible model for each design. The actual data from literature, consisting of the 2x3 and 32 and 3x4 factorial designs are used to determine the final model. The results show that the P-Value WH and Stepwise methods give the highest percentage of matched model.
33
Gaikwad, Dinanath, Padmini Kurane, Dipak Mali, and Namdeo Jadhav. "DEVELOPMENT OF PARTICULATE MUCOADHESIVE GEL FOR INTRANASAL DELIVERY." Asian Journal of Pharmaceutical and Clinical Research 10, no. 5 (2017): 222. http://dx.doi.org/10.22159/ajpcr.2017.v10i5.17212.
Full textAbstract:
Objective: The objective of this research work was to develop mucoadhesive particulates gel of Propranolol HCl for intranasal delivery.Method: Drug loaded mucoadhesive particulates were prepared by spray drying technique using polymers such as HPMC K100 and Carbopol 934P. Batches were prepared according to 32 factorial designs. Result: The mucoadhesive particulates prepared were evaluated for different parameters like drug content, entrapment efficiency, mucoadhesive strength and in vitro drug release. IR, XRD and DSC study revealed that there were no interaction occurs between drug and excipients and confirming reduction in crystallinity. The swelling index and encapsulation efficiency was found to be (0.9266%), (97.44%), angle of repose, Carr’s compressibility index falls in acceptable limits. At the end of 10 hr optimized batch showed 90.23 % drug release and followed zero order release kinetics.Conclusion: Conclusion from result of the studies such as increase in the concentration of polymers contributed in drug release retardation. Although, prepared formulation of nasal administration can be a value addition in treatment for heart diseases like angina pectoris, myocardialKeywords: Mucoadhesive, Particulates, Propranolol hydrochloride, Intranasal.infraction.
34
Gupta, Sudhir, and Kamal Singh Rathore. "Formulation and Evaluation of Novel Lipid-Based Nanocarriers for Targeted Ocular Delivery of Prednisolone Acetate." Journal of Neonatal Surgery 14, no. 17S (2025): 36–51. https://doi.org/10.63682/jns.v14i17s.4469.
Full textAbstract:
Objective: In the present research work, the aim was to prepare and evaluate prednisolone acetate solid lipid nanoparticles at eye surface for the treatment of ocular inflammation. Methods: Solid lipid nanoparticles were prepared by high pressure homogenization followed by probe sonication. The amounts of polymers were selected on the basis of optimum quantity required for sustained release of drugfrom preparation and as reported in literature and performed ranging study. Results and discussion: Glyceryl monostearate, Tween 80 and transcutol P were used as solid lipid, surfactant and co-surfactant respectively. All formulation was evaluated for particle size, zeta potential, entrapment efficiency % drug content and release study. Nine formulations for each approach were prepared and optimized successfully using 32 factorial designs. Optimization was done by DoE software version Version 13.0.10.064. Conclusion: Solid lipid nanoparticles were successfully developed using high pressure homogenization method. Results of the various parameters indicated that prednisolone acetate can be formulated into nanoparticles using GMS thereby improving its ocular permeability. Stability studies indicated no change in coloration or any other physical parameters.
35
Sachan, A. K., A. Gupta, K. Kumari, and A. Ansari. "FORMULATION AND CHARACTERIZATION OF MICROSPHERES OF NITAZOXANIDE BY CHEMICAL CROSSLINKING METHOD." Journal of Drug Delivery and Therapeutics 8, no. 5 (2018): 190–99. http://dx.doi.org/10.22270/jddt.v8i5.1850.
Full textAbstract:
The work investigated the design and evaluation of microspheres of Nitazoxanide by Ionotropic gelation technique met. 32 Factorial designs were used and concentration of polymer carbopol-934 (X1) and Ethyl cellulose (X2) were selected as the independent variables. The surface morphology study by SEM indicated that microspheres were spherical with smooth surface. There was no interaction between the drug and polymers, as studied by FTIR study. The prepared microspheres were characterized by entrapment efficiency, particle size micromeritic properties. It was observed that on increasing polymer concentration of formulations, % yield, the entrapment efficiency and particle size were increased whereas % drug release decreased. The In Vitro release study was done using U.S.P. dissolution rate basket type apparatus in phosphate buffer pH 7.4 for 10 hr. It shows that on increasing polymer concentration the drug release of all formulations was gradually decreased. In Vitro mucoadhesion study depicts that as the polymer concentration increased, mucoadhesive nature of the formulation was also increased. The microspheres of NTZ (formulation F9) showed best results due to highest drug entrapment efficiency (85.50%), and percentage drug release after 10.0 hr. was 50.25%. The rate of release followed First order kinetics. The microspheres exhibits good mucoadhesive properties in in- vitro wash-off test at pH 7.4 (Intestinal pH) than pH 1.2 (gastric pH),because the drug was completely absorbed in Gastrointestinal tract, Therefore, it can be concluded that Nitazoxanide Loaded algino-carbopol-934 microspheres can be formulated for sustained drug delivery of Nitazoxanide used in Chronic Hipatitis-C.
 Keywords: Mucoadhesive microspheres, Nitazoxanide, Carbopol-934, Ethyl cellulose, Sodium Alginate, Factorial design.
36
Hangargekar, Sachin R., Pradeep K. Mohanty, and Ashish Jain. "Formulation and Evaluation of Solid Lipid Nanoparticles of Sertraline Hydrochloride." International Journal of Pharmaceutical Sciences and Drug Research 13, no. 02 (2020): 152–57. http://dx.doi.org/10.25004/ijpsdr.2021.130206.
Full textAbstract:
Depression is a global affective and common mental disorder, with over 264 million people experiencing it. It is characterized by depressed mood, loss of interest, feelings of guilt or low self-worth, disturbed sleep or appetite, and poor concentration. A new class of colloidal delivery system has been introduced that encompasses a number of advantages over the conventional dosage forms and one of it includes the solid lipid nanoparticles (SLN) with the major advantage of been controlled and site-specific drug delivery. It is made up of a solid core and phospholipid shell having high drug loading to enhance bioavailability. Sertraline hydrochloride is an antidepressant drug used for brain targeting. The main objective of the work was to formulate Sertraline hydrochloride-loaded solid lipid nanoparticles and to screen the effect of formulation with process variables on the performance of these formulated solid lipid nanoparticles. Hot homogenization technique was used to formulate the solid lipid nanoparticles using of 32 factorial designs. The effect of independent variables on the concentration of Poloxamer 188 and Glyceryl monosterate on viscosity and drug release was studied. SLNs containing sertraline hydrochloride were prepared and evaluated. The results depicted F6 as an optimized formulation with an entrapment efficiency of 87.36 ± 1.45% and a drug release of 84.26 ± 1.10%. With the thorough screening study, the enrichment of Sertraline hydrochloride entrapment was attained with good particle size and controlled release. The factorial design confirmed its influence and significance in determining and understanding both formulation and process variables affecting the quality of SLNs.
37
EFUWAPE, BIODUN, T., AZEEZAT A. O. ADEBAYO, KHADIJHA-KUBURAT ADEBISI ABDULLAH, and TEMITOPE O. EFUWAPE. "EVALUATING THE EFFECT OF NIGERIA ROAD SAFETY STRATEGY ON ROAD TRAFFIC CRASHES IN THE SIX GEO-POLITICAL ZONES USING 3k FACTORIAL DESIGN." FUDMA JOURNAL OF SCIENCES 6, no. 3 (2022): 123–29. http://dx.doi.org/10.33003/fjs-2022-0603-966.
Full textAbstract:
Road Traffic Crashes (RTCs) has become a major challenge and threat to human health and safety. This research was conducted to investigate the effect of Nigeria Road Safety Strategy (NRSS) on RTCs in the six geo-political zones of the country. The dataset used was obtained from the annual records of Federal Road Safety Commission (FRSC) over a five year period (2016 – 2020).The dataset was subjected to Bartlett’s test of Homogeneity assumption which was not violated. Duncan Multiple Range Test was carried out to evaluate the differences in the groups. Three levels of road traffic crashes (no of cases, total casualties, and number of people involved) in the two regions of the Northern (North-Central, North-East and North-West) and Southern (South-West, South - South and South - East) Nigeria with six geo-political zones were modeled by linear regression analysis, and further subjected to 32 Factorial Designs with Analysis of Variance (ANOVA), using R-statistical package. Results of the study shows that total cases and the corresponding number of people involved in RTCs in the two regions are significant. 97% and 96% of the total variations in RTCs were explained by the variations in geo-political zones in both regions respectively. This affirms the fact that the models for the two regions were different with the rate of RTCs higher in the northern region than in the southern region
38
Ingwell, Laura L., John J. Ternest, Jacob R. Pecenka, and Ian Kaplan. "Supplemental forage ameliorates the negative impact of insecticides on bumblebees in a pollinator-dependent crop." Proceedings of the Royal Society B: Biological Sciences 288, no. 1953 (2021): 20210785. http://dx.doi.org/10.1098/rspb.2021.0785.
Full textAbstract:
Insecticide use and insufficient forage are two of the leading stressors to pollinators in agroecosystems. While these factors have been well studied individually, the experimental designs do not reflect real-world conditions where insecticide exposure and lack of forage occur simultaneously and could interactively suppress pollinator health. Using outdoor enclosures, we tested the effects of insecticides (imidacloprid + lambda-cyhalothrin) and non-crop forage (clover) in a factorial design, measuring the survival, behaviour and performance of bumblebees ( Bombus impatiens ), as well as pollination of the focal crop, watermelon. Colony survival was synergistically reduced to 17% in watermelon alone + insecticides (survival was 100% in all other treatments). However, behavioural shifts in foraging were mainly owing to insecticides (e.g. 95% reduced visitation rate to watermelon flowers), while impacts on hive performance were primarily driven by clover presence (e.g. 374% increase in the number of live eggs). Insecticide-mediated reductions in foraging decreased crop pollination (fruit set) by 32%. Altogether, these data indicate that both insecticides and non-crop forage play integral roles in shaping pollinator health in agricultural landscapes, but the relative importance and interaction of these two factors depend on which aspect of ‘health’ is being considered.
39
Rocha Pereira, Tais, Albert E. Patterson, and Sherri L. Messimer. "Buckling Strength of 3-D Printed Thermoplastic Thin Shells: Notes on an Exploratory Study of As-Printed and Reinforced Cases." Applied Sciences 10, no. 17 (2020): 5863. http://dx.doi.org/10.3390/app10175863.
Full textAbstract:
Additively-manufactured (AM) materials have a defined mesostructure and natural voids which impact their structural stability; thin shells, which do not have the bulk to support or absorb the effects of the variances in properties, are particularly affected. Thin shells are a common feature in many designs, providing good strength-to-weight ratios for many applications, particularly in the aerospace and structural design domains. The use of AM to fabricate thin structures could both expand the use of AM and improve the application space for thin structures in design, but this problem has not yet been widely discussed for buckling cases. This short technical note explored this problem for thermoplastic thin shells fabricated by fused deposition modeling (FDM), providing insight into the problem, some initial experimental results, and discussion of design implications. A designed 2(4−1) factorial experiment was used to study the buckling behavior, examining the impact of wall thickness, material, and two methods for internal reinforcement (soft infill and polyurethane foam). Analysis of variance (ANOVA) (including model adequacy testing and proof of Fisher Assumption validity) was completed on data from two replications (32 total tests), providing useful information on the significance of the factors and their interactions.
40
Saifee, Maria, Pragati Bhaske, and Reshma Toshniwal. "FORMULATION AND EVALUATION OF SIMVASTATIN LOADED MICROEMULSION BASED GEL: IN VITRO CHARACTERIZATION." International Research Journal of Pharmacy 12, no. 7 (2021): 1–7. http://dx.doi.org/10.7897/2230-8407.1207149.
Full textAbstract:
The Simvastatin loaded microemulsion based gel was formulated and in-vitro evaluation was done for the treatment of diabetic wound healing. Simvastatin is BCS class II drug which promotes wound healing by increasing the production of vascular endothelial growth factor (VEGF). Microemulsions (MEs) are oil and water colloidal system stabilized by the mixture of surfactant and co-surfactant offering enhance skin permeability for both hydrophobic and hydrophilic drugs. At first, microemulsion (ME) was prepared by water titration method and the existence of ME region was determined using pseudo-ternary phase diagram. Formulations were prepared using oil (oleic acid), Tween 80 and PEG 400 as surfactant and co-surfactant. Optimization of formulation was done using 32 factorial designs. Carbopol 940 was used as gelling agent for preparing microemulsion gel. The formulations were evaluated for physical appearance globule size, polydispersity index, zeta potential, percent transmittance, thermodynamic stability, dilution test, drug content, and in vitro drug release. The optimized formulation of ME showed average globule size of 151 nm and the optimized ME gel had a homogeneous texture, showed good spreadability and in vitro drug release. The present study indicates the simvastatin loaded microemulsion gel could act as promising vehicle for topical drug delivery of drug for diabetic wound healing.
41
Sanket, Shinde, Jagdale Swati, Dargude Shrikant, and Polshettiwar Satish. "Enhancement of Solubility by Hydrotropic Techniques of Lercanidipine HCl: In-situ Nasal Gel Development." INTERNATIONAL JOURNAL OF PHARMACEUTICAL QUALITY ASSURANCE 15, no. 02 (2024): 698–705. http://dx.doi.org/10.25258/ijpqa.15.2.23.
Full textAbstract:
Lercanidipine HCl is a novel, third-generation, potent, vasoselective 1, 4- dihydropyridine calcium channel antagonist and a Biopharmaceutical Classification System (BCS) class II drug that aids in preventing hypertension. The final aim of the present work was to promote the solubility of lercanidipine HCl via hydrotrophy and then include it in the in-situ gel formulation. This enhancement of drug solubility was carried out by using citric acid as a hydrotropic agent. Simultaneously, using a mixture of two polymers, namely Poloxamer 407, a thermosensitive polymer with reversible thermal characteristics. Carbopol 940P is a high-viscosity builder exploited for developing in-situ gel. The optimization of preliminary batches of mixtures of both polymers was highly accepted by using 32 factorial designs. F4 was found to be highly optimized, according to all the evaluation parameters and Poloxamer 407 (18% w/v) and Carbopol 940P (0.2% w/v), with drug release of 93.23%. Goat mucosa ex-vivo investigation yielded a value of 79.14% flux at 6 hours. According to ICH guidance, the in-situ Lercanidipine HCl gel has turned up to be stable following a 6-month stability investigation. Thus, the subsequent thermoreversible in-situ gel was scouted to act as a potent nasal distributor with greater bioavailability and patient compliance for the nasal medication.
42
Imlauer Vedoya, Camila María, María Cristina Area, Natalia Raffaeli, and Fernando Esteban Felissia. "Study on Soda–Ethanol Delignification of Pine Sawdust for a Biorefinery." Sustainability 14, no. 11 (2022): 6660. http://dx.doi.org/10.3390/su14116660.
Full textAbstract:
The soda–ethanol process was conceived as a sulfur-free pulping process, which may also be an alternative to conventional alkaline pulping, such as kraft or soda–AQ in the biorefinery context. An in-depth study using two experimental designs was conducted to establish the viability of soda–ethanol delignification of pine sawdust. At first, a simple factorial design involving the ethanol–water ratio (ethanol:water) and the alkaline load (AL, % over dry wood, odw) was applied to define the levels of these variables and their eventual interaction. Then, a 32 experimental design was performed to evaluate the ability of the process concerning the pulping of pine sawdust. The tested conditions were carefully selected to screen a broad range of cooking times (60, 100, and 140 min) and alkaline loads (19.0, 23.3, and 27.6 %odw) to obtain pulps with different extents of delignification (residual lignin contents). Finally, the kraft, soda–AQ, and soda–ethanol treatments were compared. Soda–ethanol pulping was shown to be a suitable delignification stage for a biorefinery scheme of Pinus elliottii and Pinus taeda sawdust. It has many advantages over traditional processes regarding its environmental impact, harmless chemicals, and selectivity. The tested conditions were similar to those frequently used in conventional pulping at an industrial scale, suggesting the technical feasibility of the soda–ethanol process for pine sawdust processing.
43
Chaudhari, Pallavi M. "Optimization and Evaluation of In situ Nasal Gel of Donepezil Hydrochloride." Asian Pacific Journal of Health Sciences 8, no. 2 (2021): 104–10. http://dx.doi.org/10.21276/apjhs.2021.8.2.20.
Full textAbstract:
Introduction: The nasal route has been explored as a route of administration, due to the benefits it offers. The formulation in the form of in situ gel has been utilized for the local and systemic effect. This type of formulation first exists in sol form, but once they are administered, it undergoes gelation to form gel, and this approach can be used for successful drug delivery system. Methods: Thus, in the present study, formulation of in situ gel for nasal administration for donepezil hydrochloride (HCL), by the use of 32 factorial designs, to improve its nasal bioavailability, was developed by increasing its nasal retention time and arrive at an optimized formulation. The formulation was developed by the use of cold method, by incorporation of thermoreversible polymer poloxamer 407 and mucoadhesive agent tragacanth. The in situ gel was later evaluated for different parameters such as pH, gelation time gelation temperature, gel strength, drug content, mucoadhesion, viscosity, in vitro drug diffusion, and stability. Results: Based on results obtained, F5 formulation was found to be optimum. The concentration of 22.5% Poloxamer 407 with 0.07% tragacanth showed promising nasal drug delivery system for donepezil HCl, with enhanced residence time due to increase in viscosity and mucoadhesion characteristics. Conclusion: The use of in situ gel formulation thus can effectively and safely improve the nasal residence time and absorption of donepezil HCl.
44
Chinmaya Mahapatra, Padala Narasimha Murthy, Anjan Kumar Mahapatra, Sudhir Kumar Sahoo, and Prasanna Kumar Dixit. "Development, characterization and optimization of polymeric mucoadhesive microcapsules containing anticancer agent using response surface method: in vitro and in vivo study." International Journal of Research in Pharmaceutical Sciences 11, no. 3 (2020): 3429–42. http://dx.doi.org/10.26452/ijrps.v11i3.2483.
Full textAbstract:
The present research work covenants the preparation, characterisation and optimisation of mucoadhesive microcapsules containing paclitaxel through ionic gelation method using 32 statistical factorial designs. The effect of mixing proportion of primary polymer sodium alginate to copolymer (X1) and speed of magnetic stirrer (X2) on the microcapsules size (Y1), efficiency of paclitaxel encapsulation (Y2), and percentage yield (Y3) was optimised. The morphology of microcapsules was characterised and evaluated by in vitro and in vivo tests to study the swelling characteristics, mucoadhesion and drug release characteristics, followed by MTT assay on human HT-29 colon cancer cell lines. The size of prepared microcapsules was within the range of 361 ± 4.50 to 931 ± 22.41; encapsulation efficiency (%) was within the range of 42.72 ± 0.43 to 98.12 ± 0.43 %. The in vitro paclitaxel released over 24 hours were in a range of 82.15 ± 3.43 % to 96.75 ± 2.41 %. The controlled release pattern of paclitaxel was observed from the in vitro drug release study of microcapsules. The prepared microcapsules that showed better mucoadhesion were in the range of 73.66 ± 1.42 to 97.85 ± 1.08 % for a period of 6 h. The in vivo pharmacokinetic study conducted in rats resulted in high Tmax, the area under the curve and mean residence time for microcapsules as compared to that of the marketed formulation. It could be concluded that the microcapsules containing povidone polymer showed superior results.
45
Wadetwar, Rita N., and Tejaswini Charde. "DESIGN, DEVELOPMENT, AND CHARACTERIZATION OF OROMUCOSAL WAFER OF TRAMADOL HYDROCHLORIDE." Asian Journal of Pharmaceutical and Clinical Research 11, no. 8 (2018): 116. http://dx.doi.org/10.22159/ajpcr.2018.v11i8.25709.
Full textAbstract:
Objective: The objective of the present work was the preparation of fast-dissolving film of tramadol HCl (TMH) using water-soluble polymer, to achieve faster onset of action, to improve patient compliance, ease of dosing, and bypass the first-pass metabolism. Methods: TMH oromucosal wafers were prepared using pullulan as natural, biodegradable polymer, and propylene glycol as plasticizer by solvent casting method. Formulation batches were prepared using 32 full-factorial designs. The prepared TMH oromucosal wafers were characterized for morphology, uniformity of weight, drug content, folding endurance, in vitro disintegration time (DT), % moisture content, surface pH, in vitro % drug release, ex vivo permeation studies, compatibility studies (differential scanning calorimetry, Fourier transform infrared spectroscopy, and X-ray diffraction), and stability studies.Results: Optimized batch of mouth-dissolving film of TMH containing pullulan as polymer showed 98.67±0.11% drug release at 6 min. It showed better folding endurance 88 No. of folds, in vitro DT 5.11 s, surface pH 6.84±0.12 pH, thickness 0.17±0.11 mm, and percentage content uniformity 98.45±0.48%. Stability studies carried out for the best formulation FDF5 revealed that the formulation was stable.Conclusion: The results obtained in this research work clearly indicated a promising potential of fast-dissolving oral films using natural biodegradable polymer, pullulan which gave rapid drug delivery and rapid onset of action of centrally acting drug, TMH for patients suffering from pain.
46
Thombre, Nilima A., Umesh D. Laddha, Eknath D. Ahire, et al. "Formulation Development and Evaluation of Herbal Antifungal Cream by using Psidium guajava Leaf Extract." INTERNATIONAL JOURNAL OF DRUG DELIVERY TECHNOLOGY 13, no. 04 (2023): 1229–34. http://dx.doi.org/10.25258/ijddt.13.4.18.
Full textAbstract:
Fungal infection is one of the major health concerns globally and varies from superficial to systemic infections. Psidium guajava Linn. leaf extract showed antifungal activity against wide range of fungi. The present research focuses on the development and investigation of cream with guava leaf extract. Ethanolic, methanolic and hydroalcoholic leaf extract was evaluated for total flavonoid content, thin layer chromatography (TLC), high-performance thin layer chromatography (HPTLC) and antifungal activity against Candida albicans. Further cream-based extract was optimized using 32 factorial designs. Beeswax and tween 80 were selected as the independent variables whose impact was studied on viscosity and %cumulative drug diffusion. Optimized cream was characterized by appearance, pH, washability, spreadability, in-vitro drug diffusion study, antifungal test and skin irritation test on wistar rats. The hydroalcoholic extract showed the highest content of flavonoids and a better zone of inhibition (27 ± 1 mm). HPTLC results confirmed the presence of essential flavonoids. Cream with 6% beeswax and 5% tween 80 with a viscosity 10420 cP and 70% drug diffusion was considered as optimized batch. The prepared cream showed satisfactory results for all evaluated parameters. The antifungal test showed the highest zone of inhibition for cream (25 mm) in comparison to standard formulation (23 mm). No any sign of skin irritation was observed. The prepared formulation is the best suitable alternative for the available topical antifungal formulation
47
Mihajlović, M., N. Perišić, L. Pezo, et al. "Optimization of process parameters to obtain NH4-clinoptilolite as a supplement to ecological fertilizer." Clay Minerals 49, no. 5 (2014): 735–45. http://dx.doi.org/10.1180/claymin.2014.049.5.09.
Full textAbstract:
AbstractThe application of natural fertilizer mixtures that improve nutrient retention ability of soils has attracted considerable attention in recent years. In addition to rock phosphate (RP), the basic components of these mixtures are zeolites modified with selected cations, such as the ammonium ion. The NH4-zeolite serves as a carrier of nutrients as well as a soil conditioner, and it promotes the RP dissolution in all soil types. The purpose of the present work was to prepare costeffective NH4-zeolite supplement, using 32 full factorial experimental designs, with concentration of modifier and processing time as variables. Saturation processes were carried out on two types of natural zeolites, K- clinoptilolite (K-Cp) and Ca-clinoptilolite (Ca-Cp). The Response Surface Method (RSM) was applied for evaluation of cation exchange, suggesting an effective NH4+ modification of natural zeolite at lower quantities of modifier than commonly found in other studies on the topic. Using Principal Component Analysis (PCA), differences between samples relative to the process variables were clearly outlined and correlated with concentrations of the exchanged cations. The best results were obtained for the K-Cp type modified with 1.5 M solution of ammonium sulfate (at a Cp/NH4+ stochiometric ratio 1:7.5) for all three processing intervals. By optimizing the modification process parameters, an experimental design of partially saturated NH4-Cp supplement that has the potential to supply all major plant nutrients was proposed.
48
Chaudhari, Priyanka Dilip, Amol Bhalchandra Deore, Manoj Jagannath Jagtap, and Devanshi Sunil Gupta. "Formulation Development and Evaluation of Mucoadhesive Buccal Tablets of Acebutolol Hydrochloride." Asian Journal of Pharmaceutical Research and Development 10, no. 4 (2022): 34–46. http://dx.doi.org/10.22270/ajprd.v10i4.1156.
Full textAbstract:
A mucoadhesive drug delivery system is an oral dosage form, where the tablet, gel, or patch is attached to the buccal region for direct absorption of the drug into blood circulation. This dosage form has been employed to improve the bioavailability of drugs that undergoes significant hepatic first-pass metabolism. Acebutolol is a beta sympatholytic agent used to treat high blood pressure and irregular heartbeat (arrhythmia). Lowering high blood pressure helps prevent strokes, heart attacks, and kidney problems. In present investigation, mucoadhesive buccal tablets of acebutolol HCl were prepared using carbopol 940 in varying concentrations with secondary polymer xanthan gum by direct compression method. Nine batches were prepared as per 32 factorial designs, to investigate the combined effects of independent variables namely carbopol 940 and xanthan gum on dependant variables namely swelling index, mucoadhesion strength and in-vitro drug release using design expert software version 8.0.7.1. Preformulation studies confirmed the identity and purity of the drug by means of UV spectroscopy, IR spectroscopy, DSC analysis, and melting point determination. The tablets were evaluated for hardness, thickness, weight variation, friability, and drug content concluded that all these parameters were in an acceptable range of pharmacopoeial specification. The buccal tablets were studied for surface pH, swelling index, in vitro drug release study, adhesion force, in vitro mucoadhesive strength, stability, and compatibility study to optimise the formula. Amongst all factorial batches (F1 to F9), batch F5 (30 mg carbopol 940 and 30 mg xanthan gum) showed maximum drug release of 99.96 % after 12 hr of study and also showed better contact with biological membrane. The drug release kinetics of batch F5 was found to be best fitted to zero order kinetic model and exhibited anomalous diffusion release mechanism. The formulation F5 exhibited good correlation (R2=0.992) for in-vitro drug release. All the evaluation parameters give positive results and comply with the standards. Stability studies were carried out on the developed formulations indicating that the formulations were stable during the period of 6 months. In conclusion, the formulation F5 is stable and effective for quick action and seems to be alternative to the conventional tablet.
49
Dev, Asish, Jayesh Dwivedi, and Munira Momin. "Formulation and characterization of acyclovir based topical microemulsions by QBD approach." Journal of Drug Delivery and Therapeutics 9, no. 1 (2019): 237–43. http://dx.doi.org/10.22270/jddt.v9i1.2230.
Full textAbstract:
Objective: The proposed study is focussed at developing acyclovir microemulsions for topical drug delivery systems. QbD was applied for better understanding of the process and to generate design space, using quality target product profile, critical quality attributes, and risk assessment. The aim of the experiment is to prepare a safe, efficacious, stable and patient compliant microemulsion dosage form of Acyclovir. Materials and methods: Pre-formulation studies were carried out which helped in developing a suitable dosage form. UV, FTIR and DSC studies were done for pre-formulation and post-formulation evaluations. QbD was applied to generate design space, using QTPP, CQA, and risk assessment. Microemulsions of acyclovir were developed by using 32 factorial designs. Pseudo terneary phase diagrams were constructed to screen various surfactants and co-surfactants for the preparation of microemulsions. Two independent variables Oil Concentration (X1) and Smix Concentration (X2) at three levels low, medium and high were selected and response surface plots were generated. The microemulsions were prepared by plotting pseudo terneary phase diagrams. Various characterizations that were carried out include % transmittance, Viscosity and % drug release. Statistical analyses of batches and surface response studies were done to understand the effect of various independent variables on the dependent variables. Results and Discussions: The λmax was confirmed at 251 nm by UV spectroscopy. The melting point was determined experimentally to be 2460C which confirms the drug to be Acyclovir. FTIR and DSC studies confirmed that the drug is Acyclovir. Conclusion: The study indicates that microemulsions of Acyclovir by QbD approach were successfully developed.
 Keywords: Microemulsion, Acyclovir, DoE, QbD
50
Elsayed, Mahmoud M. A., Moustafa O. Aboelez, Mohamed S. Mohamed, et al. "Tailoring of Rosuvastatin Calcium and Atenolol Bilayer Tablets for the Management of Hyperlipidemia Associated with Hypertension: A Preclinical Study." Pharmaceutics 14, no. 8 (2022): 1629. http://dx.doi.org/10.3390/pharmaceutics14081629.
Full textAbstract:
Hyperlipidemia is still the leading cause of heart disease in patients with hypertension. The purpose of this study is to make rosuvastatin calcium (ROS) and atenolol (AT) bilayer tablets to treat coexisting dyslipidemia and hypertension with a single product. ROS was chosen for the immediate-release layer of the constructed tablets, whereas AT was chosen for the sustained-release layer. The solid dispersion of ROS with sorbitol (1:3 w/w) was utilized in the immediate-release layer while hydroxypropyl methylcellulose (HPMC), ethylcellulose (EC), and sodium bicarbonate were incorporated into the floating sustained-release layer. The concentrations of HPMC and EC were optimized by employing 32 full factorial designs to sustain AT release. The bilayer tablets were prepared by the direct compression method. The immediate-release layer revealed that 92.34 ± 2.27% of ROS was released within 60 min at a pH of 1.2. The second sustained-release layer of the bilayer tablets exhibited delayed release of AT (96.65 ± 3.36% within 12 h) under the same conditions. The release of ROS and AT from the prepared tablets was found to obey the non-Fickian diffusion and mixed models (zero-order, Higuchi and Korsmeyer–Peppas), respectively. Preclinical studies using rabbit models investigated the impact of ROS/AT tablets on lipid profiles and blood pressure. A high-fat diet was used to induce obesity in rabbits. Bilayer ROS/AT tablets had a remarkable effect on decreasing the lipid profiles, slowing weight gain, and lowering blood pressure to normal levels when compared to the control group.