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Journal articles on the topic '32 Full-Factorial Design'

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Published: 3 June 2025
Last updated: 31 July 2025

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1

Bajwa, Prabhjot Singh, Jaya Sharma, Anurag Bhargava, Shailesh Sharma, Abhimanyu Rai Sharma, and Binu Raina Raina. "Design and development of immediate release tablets of terbutaline sulfate using 32 full factorial statistical design." Asian Pacific Journal of Health Sciences 5, no. 1 (2018): 47–52. http://dx.doi.org/10.21276/apjhs.2018.5.1.11.

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Dhamane, Suchita Prabhakar, and Swati Chagdeo Jagdale. "Development of Rifampicin loaded Chitosan nanoparticles by 32 full Factorial design." Research Journal of Pharmacy and Technology 13, no. 6 (2020): 2545. http://dx.doi.org/10.5958/0974-360x.2020.00453.9.

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Katsarov, Plamen D., Bissera A. Pilicheva, Hristo M. Manev, Paolina K. Lukova, and Margarita I. Kassarova. "Optimization of Chitosan Microspheres Spray Drying via 32 Full Factorial Design." Folia Medica 59, no. 3 (2017): 310–17. http://dx.doi.org/10.1515/folmed-2017-0037.

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AbstractBackground:Generally, the preparation of spray-dried microspheres is strongly affected by the process parameters. Particle size and production yield are mainly influenced by the spraying solution concentration and the pump rate of the spray dryer.Aim:The aim of this study was to assess optimum spray drying parameters - polymer concentration and pump rate required for the production of chitosan microspheres with high production yield and targeted for nasal administration particle size.Materials and methods:Full 32factorial design was used to study the investigated parameters. Three diff
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Zalte, Amar Gangadhar, and Ravindranath Bhanudas Saudagar. "Preparation and Characterization of Etodolac Co-Crystals Using 32 Full Factorial Design." Research Journal of Pharmacy and Technology 11, no. 9 (2018): 3781. http://dx.doi.org/10.5958/0974-360x.2018.00693.5.

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5

Kyada, C., K. Ranch, and D. Shah. "Optimization of Mucoadhesive Microspheres of Acyclovir by Applying 32 Full Factorial Design." Journal of Drug Delivery Science and Technology 24, no. 1 (2014): 61–68. http://dx.doi.org/10.1016/s1773-2247(14)50009-3.

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6

K., Latha. "Design, development and optimization of carvedilol microspheres using 32 factorial design." Journal of Biodiversity and Environmental Sciences (JBES) 24, no. 5 (2024): 140–52. https://doi.org/10.5281/zenodo.14979375.

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Carvedilol being a BCS class II drug has low solubility and it has short half-life of 2-6 hrs. The objective of the study is to design, develop and optimize carvedilol microspheres using factorial design. Solubility was enhanced by formulating into solid dispersion using solvent evaporation technique and solid dispersion with enhanced solubility was incorporated into sodium alginate microspheres prepared by ionic gelation method and were optimized by 3-level, 2-factor full factorial design. Solid dispersion formulation SD3 showed 15.3 folds enhanced solubility compared to the pure drug. Powder
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Singh, Namrata, and Surya Prakash Gupta. "Formulation and Evaluation of Naringin Loaded Transdermal Patches using 32 Full Factorial Design." INTERNATIONAL JOURNAL OF DRUG DELIVERY TECHNOLOGY 14, no. 02 (2024): 664–69. http://dx.doi.org/10.25258/ijddt.14.2.08.

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The main goal of the current study was to maximize the bioavailability of naringin by prolonging the drug’s release using transdermal patches. Ethyl cellulose (EC) served as the lipophilic component and hydroxy propyl methyl cellulose (HPMC) as the hydrophilic matrix in the preparation of transdermal patches. A 32-complete factorial technique was used to build the optimal design matrix, altering the ratio between the hydrophilic and lipophilic matrices. To create the best optimum formulation, three alternative ratios of EC and HPMC were employed. The patches had pH values ranging from 5.28 ± 0
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Sharma, Jai B., Vishal Sharma, Manish Kumar, and Shailendra Bhatt. "DESIGN AND OPTIMIZATION OF SIMVASTATIN LOADED SOLID LIPID NANOPARTICLES USING FULL FACTORIAL DESIGN." Indian Drugs 59, no. 12 (2022): 31–39. http://dx.doi.org/10.53879/id.59.12.12795.

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In the present study solid lipid nanoparticles (SLNs) of simvastatin were formulated using glyceryl monostearate and stearic acid in the ratio of 1:1 by applying 32 factorial design. The SLNs were optimized to check the effect of melted lipid and surfactant concentration on particle size and entrapment efficiency. A total of 12 formulations were prepared and characterization parameters were studied. The optimized formulation was selected by studying the interaction between the factors using polynomial equations and 3D response plots. Particle size and percentage entrapment efficiency of optimi
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Patel, Hetal, Hiral Patel, Mukesh Gohel, and Sanjay Tiwari. "Dissolution rate improvement of telmisartan through modified MCC pellets using 32 full factorial design." Saudi Pharmaceutical Journal 24, no. 5 (2016): 579–87. http://dx.doi.org/10.1016/j.jsps.2015.03.007.

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Patel, Sachi, Hiral Koradia, and Rajesh Parikh. "Design and development of intranasal in situ gelling system of Midazolam hydrochloride using 32 full factorial design." Journal of Drug Delivery Science and Technology 30 (December 2015): 154–62. http://dx.doi.org/10.1016/j.jddst.2015.10.010.

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11

Kothiya, Olvishkumar M., Bhavana A. Patel, Kunal N. Patel, and Madhubhai M. Patel. "FORMULATION AND CHARACTERIZATION OF SUSTAINED RELEASE MATRIX TABLETS OF IVABRADINE USING 32 FULL FACTORIAL DESIGN." International Journal of Applied Pharmaceutics 10, no. 1 (2018): 59. http://dx.doi.org/10.22159/ijap.2018v10i1.21584.

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Objective: Ivabradine (IB) is anti-Ischemic drug and used for the symptomatic management of stable angina pectoris. IB acts by reducing the heart rate in a mechanism different from beta blockers and calcium channel blockers, two commonly prescribed anti-anginal drugs. IB has a short biological half-life and the dose of 5/7.5 mg twice a day. In this present study, an attempt has been made to prepare sustained release tablet of IB to achieve the desired drug release.Methods: The sustained release polymers, hydroxypropyl methylcellulose K100M (HPMC K100M), guar gum (GG) and xanthan gum (XG) were
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Raina, Binu, Birendra C. Shrivastava, Anurag Bhargava, Shailesh Sharma, Abhimanyu Rai Sharma, and Prabhjot Singh Bajwa. "Design, development and optimization of immediate release tablet of deflazacort." Journal of Drug Delivery and Therapeutics 9, no. 2 (2019): 250–54. http://dx.doi.org/10.22270/jddt.v9i2.2411.

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The objective of the present study was to prepare immediate release tablets (IRTs) of deflazacort by direct compression method. Two types of superdisintegrants i.e. sodium starch glycolate (SSG) and Ac-Di-sol were used in the formulation of tablets. Twelve preliminary batches were prepared by varying the concentration of superdisintegrants. It was found that formulation containing Ac-Di-Sol disintegrated in less time as compared to formulation containing sodium starch glycolate. Values of friability was found to be more in case of formulation containing Ac-Di-Sol. Attempts were also made to pr
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Sharma, Abhimanyu Rai, Birendra Shrivastava, Anurag Bhargava, Shailesh Sharma, Binu Raina, and Prabhjot Singh Bajwa. "Design development and optimization of immediate release tablet of valsartan." Journal of Drug Delivery and Therapeutics 9, no. 2-s (2019): 43–47. http://dx.doi.org/10.22270/jddt.v9i2-s.2444.

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The objective of the present study was to prepare immediate release tablets (IRTs) of valsartan by direct compression method. Two types of superdisintegrants i.e. sodium starch glycolate (SSG) and Ac-Di-sol were used in the formulation of tablets. Twelve preliminary trial batches were prepared by varying the concentration of superdisintegrants. It was found that formulation containing Ac-Di-Sol disintegrated in less time as compared to formulation containing sodium starch glycolate. Values of friability was found to be more in case of formulation containing Ac-Di-Sol. Attempts were also made t
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14

Boldhane, Sanjay, and Bhanudas Kuchekar. "Gastroretentive Drug Delivery of Metformin Hydrochloride: Formulation and In Vitro Evaluation Using 32 Full Factorial Design." Current Drug Delivery 6, no. 5 (2009): 477–85. http://dx.doi.org/10.2174/156720109789941641.

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15

Prajapati, Bhupendra G., Malay Jivani, and Himanshu Paliwal. "FORMULATION AND OPTIMIZATION OF TOPICAL NANOEMULSION BASED GEL OF MOMETASONE FUROATE USING 32 FULL FACTORIAL DESIGN." INDIAN DRUGS 58, no. 06 (2021): 19–29. http://dx.doi.org/10.53879/id.58.06.12796.

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Mometasone furoate (MF) is a glucocorticoid prodrug that faces the problem of poor aqueous solubility. Nanoemulsion-based topical gel of MF was formulated to enhance its solubility and potential of treating skin conditions. The selection of oil, surfactant and co-surfactant was done based on their solubility with the drug. The nanoemulsion was prepared using rose oil as the oil phase. Tween 80 and Transcutol P were used as surfactant and co-surfactant and they were blended in different ratios (1:0, 1:1, 2:1 and 3:1 w/w). The pseudo ternary diagrams were developed using these excipients and for
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Deshmane, Subhash V., Aijaz A. Sheikh, Om S. Kharde, Ravindra H. Kale, and Kailash R. Biyani. "DEVELOPMENT AND EVALUATION OF FLOATING TABLET CONTAINING NEVIRAPINE USING A 32 FULL FACTORIAL DESIGN OPTIMIZATION METHOD." International Research Journal of Pharmacy 10, no. 6 (2019): 37–42. http://dx.doi.org/10.7897/2230-8407.1006200.

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17

Rao, Monica RP, Vijay Sonavane, Sayali Kulkarni, Mayuri Magar, Abhishek Zope, and Pooja Karanjkar. "Design of transdermal patch of ketoprofen by full factorial design for treatment of rheumatoid arthritis." Journal of Drug Delivery and Therapeutics 9, no. 2 (2019): 197–205. http://dx.doi.org/10.22270/jddt.v9i2.2549.

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Oral therapy of NSAIDs for treatment of rheumatoid arthritis causes gastric irritation and ulceration. In the present study transdermal patch of ketoprofen was developed using hydroxyl propyl methyl cellulose E5 and Eudragit S100. Patches were prepared by solvent evaporation method. Optimization was carried out by 32 factorial design with polymer concentration (HPMC E5) and plasticizer concentration (propylene glycol) as independent variables. Patches were evaluated for folding endurance, surface pH, drug content, percent moisture content, water uptake and swelling studies. Ex vivo permeation
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18

Asif, Afzal Haq, Prasanna Kumar Desu, Rajasekhar Reddy Alavala, Gudhanti Siva Naga Koteswara Rao, Nagaraja Sreeharsha, and Girish Meravanige. "Development, Statistical Optimization and Characterization of Fluvastatin Loaded Solid Lipid Nanoparticles: A 32 Factorial Design Approach." Pharmaceutics 14, no. 3 (2022): 584. http://dx.doi.org/10.3390/pharmaceutics14030584.

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The purpose of the present research work was to design, optimize, and evaluate fluvastatin-loaded solid lipid nanoparticles (FLV-SLNPs) using 32 factorial design for enhancing the bioavailability. Fluvastatin has several disadvantages, including the low solubility and substantial first-pass metabolism resulting in a low (30%) bioavailability and a short elimination half-life. FLV-SLNPs were prepared using the nano-emulsion technique. For the optimization of the FLV-SLNPs, a total of nine formulations were prepared by varying two independent factors at three levels, using full factorial design.
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Verma, Umakant, Rahul Rajput, and J. B. Naik. "Development and characterization of Fast Dissolving Film of Chitosan embedded Famotidine Using 32 Full Factorial Design Approach." Materials Today: Proceedings 5, no. 1 (2018): 408–14. http://dx.doi.org/10.1016/j.matpr.2017.11.099.

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20

Gurav, Atul Shivaji, and Ajit Shankarrao Kulkarni. "Preparation and Optimization of Microwave-Assisted Ball-Milled Olmesartan Medoxomil with Chitosan Using Full 32 Factorial Design." Indian Journal of Pharmaceutical Education and Research 57, no. 3s (2023): s555—s563. http://dx.doi.org/10.5530/ijper.57.3s.64.

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21

Payal, Yaduwanshi, Goswami Anindya, and Malviya Neelesh. "FORMULATION OPTIMIZATION AND EVALUATION OF TINIDAZOLE IN-SITU." Journal of Biomedical and Pharmaceutical Research 10, no. 2 (2021): 20–26. http://dx.doi.org/10.32553/jbpr.v10i2.856.

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The study deals with formulation optimization and evaluation of tinidazole gel by using sodium alginate as gelling agent calcium chloride, sodium citrate were used as cross linking agent. The polymeric solution of drug is in solution form before it administered to the body. But after administration when it comes in contact with acidic pH it’s converted into gel form and the drug tinidazole released from the dosage form constantly and slowly. The formulation is effective for the treatment of gastric ulcer because of Helicobacter pylori. 32 full factorial design were used for the optimization of
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22

Nair, Anroop, Jigar Shah, Bandar Al-Dhubiab, et al. "Clarithromycin Solid Lipid Nanoparticles for Topical Ocular Therapy: Optimization, Evaluation and In Vivo Studies." Pharmaceutics 13, no. 4 (2021): 523. http://dx.doi.org/10.3390/pharmaceutics13040523.

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Solid lipid nanoparticles (SLNs) are being extensively exploited as topical ocular carrier systems to enhance the bioavailability of drugs. This study investigated the prospects of drug-loaded SLNs to increase the ocular permeation and improve the therapeutic potential of clarithromycin in topical ocular therapy. SLNs were formulated by high-speed stirring and the ultra-sonication method. Solubility studies were carried out to select stearic acid as lipid former, Tween 80 as surfactant, and Transcutol P as cosurfactant. Clarithromycin-loaded SLN were optimized by fractional factorial screening
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23

Pandey, M. M., K. B. Prajapati, A. J. Vyas, et al. "Development and Validation of Stability Indicating Method for Simultaneous Estimation of Esomeprazole and Levosulpiride by HPTLC using Experimental Design." Asian Journal of Organic & Medicinal Chemistry 5, no. 3 (2020): 213–20. http://dx.doi.org/10.14233/ajomc.2020.ajomc-p273.

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The present study examines simultaneous multiple response optimization using desirability function for the development of an HPTLC method to detect esomeprazole magnesium trihydrate and levosulpiride in pharmaceutical dosage form. HPTLC separation was performed on aluminium plates pre-coated with silica gel 60 F254 as the stationary phase using ethyl acetate:methanol:toluene:ammonia (7:1.5:1.5:0.1% v/v/v) as the mobile phase. Full factorial design applied for the optimization of degradation condition. Esomeprazole magnesium trihydrate and levosulpiride were subjected to acid, alkali hydrolysis
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Shen, Zhangmin, Ying-Hsiang Chou, Cheng-Chang Lu, et al. "Evaluating environmental radiations of the tomotherapy facility by optimizing full factorial design of the TLD technique." Technology and Health Care 30 (February 25, 2022): 481–91. http://dx.doi.org/10.3233/thc-thc228044.

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BACKGROUND: In the last 40 years, the number of deaths due to cancer has been the highest in Taiwan OBJECTIVE: To optimize the readout system of the thermoluminescent dosimeter (TLD)-100H, the radiation rates among the Tomotherapy (TOMO) facility of the Department of Radiology Oncology of Chung Shan Medical University Hospital (CSMUH) were calculated with a 32 full factorial design (FFD). METHODS: A ten-month survey of the facility was employed using the sensitive and accurate TLD method. The TLD system was optimized for maximum temperature, heat rate, and preheat temperature of Harshaw 3500 r
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Singh, Jatinderpal, Rajeev Garg, and Ghanshyam Das Gupta. "Enhancement of Solubility of Lamotrigine by Solid Dispersion and Development of Orally Disintegrating Tablets Using 32 Full Factorial Design." Journal of Pharmaceutics 2015 (October 27, 2015): 1–8. http://dx.doi.org/10.1155/2015/828453.

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Present investigation deals with the preparation and evaluation of orally disintegrating tablets (ODTs) of lamotrigine using β-cyclodextrin and PVP-K30 as polymers for the preparation of solid dispersion which help in enhancement of aqueous solubility of this BCS CLASS-II drug and sodium starch glycolate (SSG) and crospovidone as a superdisintegrating agent, to reduce disintegration time. The ODTs were prepared by direct compression method. Nine formulations were developed with different ratios of superdisintegrating agents. All the formulations were evaluated for disintegration time, weight v
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Nandi, Gouranga, Amit Kumar Nandi, Najim Sarif Khan, Souvik Pal, and Sibasish Dey. "Tamarind seed gum-hydrolyzed polymethacrylamide-g–gellan beads for extended release of diclofenac sodium using 32 full factorial design." International Journal of Biological Macromolecules 114 (July 2018): 214–25. http://dx.doi.org/10.1016/j.ijbiomac.2018.03.064.

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27

Kasar, Harshada Anil, Asish Dev, and Subhakanta Dhal. "FORMULATION AND EVALUATION OF LIDOCAINE HYDROCHLORIDE CHEWABLE TABLET." Asian Journal of Pharmaceutical and Clinical Research 11, no. 11 (2018): 190. http://dx.doi.org/10.22159/ajpcr.2018.v11i11.27057.

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Objective: The objective of this study was to formulate and optimize a chewable formulation of lidocaine hydrochloride using a 32 factorial design for optimized the superdisintegrant concentration.Methods: Various concentrations of sodium starch glycolate (SSG) (13.33 mg, 26.66 mg, and 40 mg) of superdisintegrant and starch (50 mg, 83 mg, and 116.66 mg) were added in the formulation; nine formulations were prepared according to 32 factorial designs and evaluated. The responses were analyzed for analysis of variance using Design-Expert version 10 software. Statistical models were generated for
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Patel, Jalpa, and Dhaval Mori. "Application of 32 Full Factorial Design and Desirability Function for Optimizing The Manufacturing Process for Directly Compressible Multi-Functional Co-Processed Excipient." Current Drug Delivery 17, no. 6 (2020): 523–39. http://dx.doi.org/10.2174/1567201817666200508094743.

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Background: Developing a new excipient and obtaining its market approval is an expensive, time-consuming and complex process. Compared to that, the co-processing of already approved excipients has emerged as a more attractive option for bringing better characteristic excipients to the market. The application of the Design of Experiments (DoE) approach for developing co-processed excipient can make the entire process cost-effective and rapid. Objective: The aim of the present investigation was to demonstrate the applicability of the DoE approach, especially 32 full factorial design, to develop
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Faruk, Omar, Diponkor Kumar Shill, A. S. M. Monjur Al Hossain, Abu Shara Shamsur Rouf, and Uttom Kumar. "Development of a Sustained-Release Oral Tablet of Tyrosine Kinase Inhibitor Imatinib Using Full Factorial Design." Dhaka University Journal of Pharmaceutical Sciences 23, no. 2 (2024): 135–43. https://doi.org/10.3329/dujps.v23i2.78571.

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Tyrosine kinase inhibitors (TKIs) have dramatically improved the outcomes for patients with leukemia. The conventional immediate-release tablets of imatinib exhibit fluctuating plasma levels. The aim of this study was to develop sustained-release tablets of imatinib to maintain a steadier plasma drug concentration. A 32 fullfactorial design was used for the formulation optimization. The percentages of povidone K30 and methocel K15M were selected as independent variables and drug released after 24h in pH 6.8 phosphate buffer was chosen as a response. Statistical analysis of the response followe
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Shah, Purvi Apurva, Niketa Ratilal Gevariya, Jenee Robert Christian, et al. "Science based Development of Viscous Eye Drop of Dorzolamide Hydrochloride and Timolol Maleate using Full Factorial Design." Pharmaceutical Methods 9, no. 2 (2018): 10. https://doi.org/10.5281/zenodo.14586274.

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Introduction: To develop and optimize viscous eye drop for dorzolamide hydrochloride and timolol maleate used in Glaucoma - the leading cause of irreversible blindness worldwide. Methods and Materials: 32 full factorial design was applied in formulation optimization to study the relationships between critical process parameters (concentration of HPMC K15 and Carbopol 934) and critical quality attributes, i.e. viscosity, mucoadhesion index and cumulative drug release for both the drugs. Further, the optimized formulation was identified through derringer’s desirability approach of multicri
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Islam, Shawkat, Nusrath Jahan Fariha, Shakil Ahmed, Omar Faruk, and Abu Shara Shamsur Rouf. "Development and Optimization of Hydrophilic Matrix Based Molnupiravir Sustained Release Dosage Formulation using Full Factorial Design." Dhaka University Journal of Pharmaceutical Sciences 24, no. 1 (2025): 67–75. https://doi.org/10.3329/dujps.v24i1.82411.

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Molnupiravir, an orally administered antiviral drug originally developed for influenza but not approved, inhibits the replication of SARS-CoV-2 and has been repurposed as an antiviral treatment for COVID-19. This research aimed to develop 400 mg sustained release tablets of molnupiravir for a dosage regimen of two tablets every 12 hours using design of experiment (DoE) approach. The study utilized 32 full factorial design, implemented through the use of Design Expert® software. The formulation was optimized using methocel® K15M and povidone K30 as independent variables, with drug release at 2,
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Jain, Neha, Mohan L. Kori, Umesh K. Jain, and Abhishek K. Jain. "NATURAL BIODEGRADABLE CIPROFLOXACIN MICROSPHERES: OPTIMIZATION STUDY BY FACTORIAL DESIGN." Indian Drugs 59, no. 04 (2022): 24–33. http://dx.doi.org/10.53879/id.59.04.13018.

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Oral drug delivery is the most popular method of control and release of therapeutic agents for the management of diseases. The colon specific drug delivery systems are considered to attain targeted drug delivery to the large intestine specifically at colon. They provide local delivery for the treatment of colonic diseases like inflammatory bowel disease. The present investigation is based on response of percent drug release as dependent variable for the study at Y axis with two different variables-concentration of surfactant (X1) and stirring speed (X2). A 32 full factorial design was used for
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Patel, Afroza Akbar, Siraj N. Shaikh, Huzaifa Patel, Afzal Band, and Ahmed Shaoor. "Designing fabrication and evaluation of Oral fast Disintegrating tablet of Ranitidine HCL." Journal of Drug Delivery and Therapeutics 9, no. 1 (2019): 95–102. http://dx.doi.org/10.22270/jddt.v9i1.2176.

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The aim of this research work was to design develop & evaluate oral fast disintegrating tablets of Ranitidine HCL. The Orodispersible tablets of Ranitidine HCl were prepared by using direct Compression technique with a Synthetic Superdisintegrant such as Crosspovidone and a natural Superdisintegrant Fenugreek gum in different concentration. 32 factorial designs was applied to study the effect of independent variables, concentration of Crosspovidone & Fenugreek gum on dependent variables like Cumulative % Drug release and Disintegration time by using design expert software. Prepared ora
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A-A Khammas, Zuhair. "Extraction and Determination of Sildenafil Citrate by Spectrophotometry: Classical Versus Factorial Design Optimization." Tikrit Journal of Pharmaceutical Sciences 9, no. 1 (2023): 61–79. http://dx.doi.org/10.25130/tjphs.2013.9.1.7.61.79.

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In this work, the complexation and extraction processes of sildenafil citrate (SC) were evaluated by using classical optimization versus factorial design methodology. The selected factors were based on the reaction of sildenafil with methyl orange (MO) as a chromogenic reagent via the formation of ion-association complex in acidic buffer media, followed by extraction with chloroform and quantitatively measured by visible spectrophotometry at λmax of 427 nm. The optimization step was first carried out by classical one-factor-at-a-time (OFAT) from which the extracted results were exploited in th
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Bhattacharjee, Arpita, Pranab J. Das, Sanjay Dey, et al. "Development and optimization of besifloxacin hydrochloride loaded liposomal gel prepared by thin film hydration method using 32 full factorial design." Colloids and Surfaces A: Physicochemical and Engineering Aspects 585 (January 2020): 124071. http://dx.doi.org/10.1016/j.colsurfa.2019.124071.

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Hossain, Md Jahid, Diponkor Kumar Shill, Sreedam Chandra Das, Khondoker Shahin Ahmed, Hemayet Hossain, and Uttom Kumar. "Development of a Validated RP-HPLC Method Using Full Factorial Design for the Analysis of Ramipril." Dhaka University Journal of Pharmaceutical Sciences 23, no. 1 (2024): 93–102. http://dx.doi.org/10.3329/dujps.v23i1.74098.

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The primary objective of this study is to develop and optimize a simple, novel, reproducible, and efficient RP-HPLC method using quality by design (QbD) approach for the routine analysis of ramipril. The chromatographic separation was carried out by C18 column with an isocratic elution of a mobile phase of 65:35 (%v/v) acetonitrile: water at a flow rate of 0.9 mL/min. The detection was done at a wavelength of 210 nm using a photo-diode array plus (PDA+) detector. A 32 full-factorial design was employed for the development of analytical method using Design Expert® software in which the mobile p
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Kumar, Vipan, Vidhi Jain, and Manmeet Singh Saluja. "Optimization of Spirapril Controlled Release Floating Tablet Using 32 Central Composite Design." Journal of Biomedical and Pharmaceutical Research 12, no. 1 (2023): 49–56. http://dx.doi.org/10.32553/jbpr.v12i1.957.

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The aim of present investigation was to develop efficient controlled release floating tablet (CRFT) of Spirapril. Floating dosage form for gastric retention has potential to use as controlled-release drug delivery systems which providing opportunity for both local and systemic drug action. The tablets were prepared by using wet granulation techniques using PVP K 30, SFG and Acrypol 934. A 32 full factorial design (CCD) was applied to optimize two independent variables at three different levels by varied response variables. Two independent variables i.e. amount of SFG (i.e., polymer X1) and amo
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Chattopadhyay, Helen, Amit Kumar De, and Sriparna Datta. "Novel Starch-PVA Polymer for Microparticle Preparation and Optimization Using Factorial Design Study." International Scholarly Research Notices 2015 (January 12, 2015): 1–8. http://dx.doi.org/10.1155/2015/261476.

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The aim of our present work was to optimize the ratio of a very novel polymer, starch-polyvinyl alcohol (PVA), for controlled delivery of Ornidazole. Polymer-coated drug microparticles were prepared by emulsion method. Microscopic study, scanning electron microscopic study, and atomic force microscopic study revealed that the microparticles were within 10 micrometers of size with smooth spherical shape. The Fourier transform infrared spectroscopy showed absence of drug polymer interaction. A statistical 32 full factorial design was used to study the effect of different concentration of starch
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Suksaeree, Jirapornchai, and Chaowalit Monton. "Maximizing Curcuminoid Extraction from Curcuma aromatica Salisb. Rhizomes via Environmentally Friendly Microwave-Assisted Extraction Technique Using Full Factorial Design." International Journal of Food Science 2024 (March 25, 2024): 1–13. http://dx.doi.org/10.1155/2024/4566123.

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Curcuma aromatica Salisb. contains a high content of curcuminoids, which can be utilized for cosmetic purposes. The objective of this study was to optimize the extraction conditions of C. aromatica rhizomes in castor oil to maximize curcuminoid content using a simple and environmentally friendly microwave-assisted extraction method. A 32 full factorial design was employed, with two factors—microwave power and time—varying between 600-800 W and 30-90 s, respectively. Five responses were monitored, including extraction yield, bisdemethoxycurcumin, demethoxycurcumin, curcumin, and total curcumino
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Ravindra K., Kamble, Chauhan Chetan S., Kamble Priyadarshani R., and Naruka Pushpendra S. "Formulation Optimization of Sustained Release Resinate Microcapsules of Tramadol Hydrochloride by Using 3/2 Factorial Design." International Journal of Pharmaceutical and Phytopharmacological Research 6, no. 2 (2017): 57. http://dx.doi.org/10.24896/eijppr.2016621.

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The main aim of the present work was to develop the microcapsules of tramadol hydrochloride for the oral sustained release drug delivery. Tramadol hydrochloride a BCS class I drug a centrally acting synthetic analgesic was complexed with Indion 254 ion exchange resin. The microcapsules were prepared by encapsulating the prepared resinates by o/o solvent evaporation technique. In the investigation 32 full factorial design was used to investigate the joint influence of two formulation variable amount of eudragit RS 100 and plasticized PEG 400. The results of multiple linear regression analysis i
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Sharma, Meenakshi, Nitin Sharma, and Anjana Sharma. "RIZATRIPTAN BENZOATE LOADED NATURAL POLYSACCHARIDE BASED MICROSPHERES FOR NASAL DRUG DELIVERY SYSTEM." International Journal of Applied Pharmaceutics 10, no. 5 (2018): 261. http://dx.doi.org/10.22159/ijap.2018v10i5.27877.

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Objective: The objective of this research was to formulate and evaluate the different grades of rizatriptan benzoate loaded polysaccharide based microspheres for the nasal drug delivery system.Methods: The polysaccharide was extracted from the seed of Trigonella foenum-graecum and microspheres were prepared by emulsification, followed by crosslinking using epichlorohydrin. A 32 full factorial design was employed in formulating the microspheres with polymer concentration (X1), and stirring rate (X2) as independent variables and particle size (Y1) and entrapment efficiency (Y2) were dependent va
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Bagul, Uddhav S., Shubham V. Khot, Kiran S. Ashtekar, et al. "Fabrication of acetazolamide loaded leciplex for intraocular delivery: Optimization by 32 full factorial design, in vitro, ex vivo and in vivo pharmacodynamics." International Journal of Pharmaceutics 661 (August 2024): 124391. http://dx.doi.org/10.1016/j.ijpharm.2024.124391.

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Varia, Umang, Ritiksha Khatri, Hitesh Katariya, and Krunal Detholia. "FABRICATION, OPTIMIZATION AND EX-VIVO CHARACTERIZATION OF FEBUXOSTAT LOADED NANOSTRUCTURED LIPID CARRIER BY 3 SQUARE FULL FACTORIAL DESIGN." Journal of Advanced Scientific Research 13, no. 01 (2022): 269–80. http://dx.doi.org/10.55218/jasr.202213131.

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Nano Structured Lipid Carriers (NLCs) are potential alternative of the tradition colloidal drug carrier. The main benefit is related to the well-known concept that lipids used in nanoparticle formulation promote drug oral absorption because they go through the same physiological mechanism as food lipid digestion. The objective of the present work is to use potential carrier NLCs for the oral delivery of poorly soluble drug Febuxostat (FEB). FEB-NLCs were formulated by High Speed Homogenization with Ultra sonication method using Capmul GMS 50 K as solid lipid and Transcutol HP as a liquid lipid
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Aziz, Diana, Sally A. Mohamed, Saadia Tayel, and Amal Makhlouf. "Enhanced Ocular Anti-Aspergillus Activity of Tolnaftate Employing Novel Cosolvent-Modified Spanlastics: Formulation, Statistical Optimization, Kill Kinetics, Ex Vivo Trans-Corneal Permeation, In Vivo Histopathological and Susceptibility Study." Pharmaceutics 14, no. 8 (2022): 1746. http://dx.doi.org/10.3390/pharmaceutics14081746.

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Tolnaftate (TOL) is a thiocarbamate fungicidal drug used topically in the form of creams and ointments. No ocular formulations of TOL are available for fungal keratitis (FK) treatment due to its poor water solubility and unique ocular barriers. Therefore, this study aimed at developing novel modified spanlastics by modulating spanlastics composition using different glycols for enhancing TOL ocular delivery. To achieve this goal, TOL basic spanlastics were prepared by ethanol injection method using a full 32 factorial design. By applying the desirability function, the optimal formula (BS6) was
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Bansal, Amit, Deepak Kapoor, Rishi Kapil, Neha Chhabra, and Sanju Dhawan. "Design and development of paclitaxel-loaded bovine serum albumin nanoparticles for brain targeting." Acta Pharmaceutica 61, no. 2 (2011): 141–56. http://dx.doi.org/10.2478/v10007-011-0012-8.

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Design and development of paclitaxel-loaded bovine serum albumin nanoparticles for brain targeting Bovine serum albumin (BSA) nanoparticles loaded with paclitaxel (PTX) were prepared using a desolvation technique. A 32 full factorial design (FFD) was employed to formulate nanoparticles. Nanoparticles were characterized for particle size by photon correlation spectroscopy and surface morphology by scanning electron microscopy (SEM) and transmission electron microscopy (TEM). Encapsulation efficiency, zeta potential and particle yield were also determined. Response surface linear modelling (RSLM
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Borderwala, Kruti, Ganesh Swain, Namrata Mange, et al. "Optimization of Solid Lipid Nanoparticles of Ezetimibe in Combination with Simvastatin Using Quality by Design (QbD)." Nanoscience & Nanotechnology-Asia 10, no. 4 (2020): 404–18. http://dx.doi.org/10.2174/2210681209666190218143736.

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Background: The objective of this study was to develop solid lipid nanoparticles (SLNs) of poorly water soluble anti-hyperlipidemic drugs-Ezetimibe in combination with Simvastatin. Methods: This study describes a 32 full factorial experimental design to optimize the formulation of drug loaded lipid nanoparticles (SLN) by the high speed homogenization technique. The independent variables amount of lipid (GMS) and amount of surfactant (Poloxamer 188) were studied at three levels and arranged in a 32 factorial design to study the influence on the response variables- particle size, % entrapment ef
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Gajra, Balaram, Saurabh S. Pandya, Sanjay Singh, and Haribhai A. Rabari. "Mucoadhesive Hydrogel Films of Econazole Nitrate: Formulation and Optimization Using Factorial Design." Journal of Drug Delivery 2014 (June 10, 2014): 1–14. http://dx.doi.org/10.1155/2014/305863.

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The mucoadhesive hydrogel film was prepared and optimized for the purpose of local drug delivery to oral cavity for the treatment of oral Candidiasis. The mucoadhesive hydrogel film was prepared with the poly(vinyl alcohol) by freeze/thaw crosslinking technique. 32 full factorial design was employed to optimize the formulation. Number of freeze/thaw cycles (4, 6, and 8 cycles) and the concentration of the poly(vinyl alcohol) (10, 15, and 20%) were used as the independent variables whereas time required for 50% drug release, cumulative percent of drug release at 8th hour, and “k” of zero order
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Alhamhoom, Yahya, Sandip M. Honmane, Umme Hani, et al. "Study of Formulation and Process Variables for Optimization of Piroxicam Nanosuspension Using 32 Factorial Design to Improve Solubility and In Vitro Bioavailability." Polymers 15, no. 3 (2023): 483. http://dx.doi.org/10.3390/polym15030483.

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Piroxicam is a Biopharmaceutical Classification System (BCS) Class II drug having poor aqueous solubility and a short half-life. The rationale behind the present research was to develop a Piroxicam nanosuspension to enhance the solubility and thereby the in vitro bioavailability of the drug. Piroxicam nanosuspension (PRX NS) was prepared by an anti-solvent precipitation technique and optimized using a full-factorial design. Herein, the nanosuspension was prepared using polymer polyvinylpyrrolidone (PVP) K30® and Poloxamer 188® as a stabilizer to improve the solubility and in vitro bioavailabil
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Kumar, Neeraj, and Shishu Goindi. "Development, characterization and preclinical evaluation of nanosized liposomes of itraconazole for topical application: 32 full factorial design to estimate the relationship between formulation components." Journal of Drug Delivery Science and Technology 66 (December 2021): 102785. http://dx.doi.org/10.1016/j.jddst.2021.102785.

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Lay, J. J., C. J. Tsai, C. C. Huang, et al. "Influences of pH and hydraulic retention time on anaerobes converting beer processing wastes into hydrogen." Water Science and Technology 52, no. 1-2 (2005): 123–29. http://dx.doi.org/10.2166/wst.2005.0507.

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To convert high-solids organic wastes (3% w./w.) to high-value hydrogen, a full factorial experimental design was employed in planning the experiments for learning the effects of pH and hydraulic retention time (HRT) on the hydrogen production in a chemostat reactor using waste yeast obtained from beer processing wastes. For determining which experimental variable settings affect hydrogen production, predictive polynomial quadratic equation and response surface methodology were employed to determine and explain the conditions required for high-value hydrogen production. Experimental results in
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