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Journal articles on the topic '324.244 03'

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Published: 1 June 2024
Last updated: 31 July 2025

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1

Sabates, Alanis, Alayna Wood, Hope Lee, et al. "QOL-21. REAL-WORLD QUALITY-OF-LIFE AND HEALTH UTILITIES FOR PATIENTS WITH CNS CANCERS ON THE XCELSIOR PLATFORM." Neuro-Oncology 24, Supplement_7 (2022): vii245. http://dx.doi.org/10.1093/neuonc/noac209.948.

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Abstract OBJECTIVE xCures operates a direct-to-patient, real-world evidence platform according to the nationwide observational research protocol XCELSIOR (NCT03793088), which aggregates medical data in an FDA-compliant electronic database. There is a relative scarcity of published results on real-world Quality-of-Life (QoL) outcomes and resulting health state utilities for patients with Central Nervous System (CNS) cancers. We sought to use the xCures platform to help address this issue. METHODS XCELSIOR participants were invited weekly to complete the EuroQol 5-Dimension (EQ-5D-5L) QoL survey
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Alencar, Queren Hapuque Oliveira, Dagna Karen Oliveira, Mauricio Bedim dos Santos, et al. "Uso domiciliar de plantas medicinais por usuários dos serviços das Unidades Básicas de Saúde do município de Toledo, Paraná." Revista Fitos 15, no. 4 (2021): 494–507. http://dx.doi.org/10.32712/2446-4775.2021.1120.

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O uso empírico das plantas medicinais é uma prática mundialmente disseminada, cuja finalidade baseia-se no alívio/cura de algumas enfermidades. Objetivou-se caracterizar o perfil epidemiológico do uso domiciliar dessas plantas, pelos usuários de sete Unidades Básicas de Saúde com equipe Estratégia Saúde da Família, no município de Toledo/Paraná. Para tanto, foi aplicado um questionário a 324 pessoas. A análise dos dados mostrou que 89,50% dos entrevistados faziam uso de plantas medicinais, destes, 91,38% do sexo feminino, 42% com idade entre 21 e 40 anos, 30% sem concluir o ensino fundamental
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3

Bokemeyer, C., and H. J. Schmoll. "Secondary neoplasms following treatment of malignant germ cell tumors." Journal of Clinical Oncology 11, no. 9 (1993): 1703–9. http://dx.doi.org/10.1200/jco.1993.11.9.1703.

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PURPOSE The current study investigates the frequency and outcome of secondary malignancies in patients treated for testicular cancer at Hannover University Medical School between 1970 and 1990. PATIENTS AND METHODS One thousand twenty-five patients with a median follow-up duration of 61 months (range, 12 to 240) were included in the analysis. Follow-up was complete in 1,018 patients (99%). Histology was seminoma in 324 patients (38.7%) and nonseminomatous germ cell tumor in 624 patients (61.3%). At the time of median follow-up, 814 patients (79.9%) were alive. RESULTS Fourteen patients develop
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Kanze, David M. "Osteopathic Manipulative Medicine in the Era of the Single Accreditation System: Can the Past Guide the Way to the Future of OMM?" AAO Journal 30, no. 1 (2020): 17–28. http://dx.doi.org/10.53702/2375-5717-30.1.17.

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Abstract The purpose of this study was twofold: 1) to evaluate the education of osteopathic physicians who integrate osteopathic manipulative medicine in practice and attempt to find key factors that might be viewed as best practices to be adopted by colleges of osteopathic medicine (COMs), Departments of Osteopathic Manipulative Medicine (OMM), and postgraduate training programs; and 2) to evaluate if gross human anatomy was seen as valuable in OMM training. A 31-question, online survey was distributed to English-speaking members of the American Academy of Osteopathy (AAO) in the United State
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5

Suzuki, Eiichiro, John A. Bridgewater, Juan W. Valle, et al. "Sex difference in patients with biliary tract cancer receiving chemotherapy: Post hoc analysis of ABC-01, -02, -03, -04, BILCAP." Journal of Clinical Oncology 38, no. 4_suppl (2020): 517. http://dx.doi.org/10.1200/jco.2020.38.4_suppl.517.

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517 Background: The relationship between toxicity from chemotherapy and clinical outcome in biliary tract cancer (BTC) is uncertain. Aim: This post hoc analysis evaluated differences by sex in the frequency of adverse events (AEs) and overall survival (OS) and its impact on progression-free survival (PFS)/recurrence-free survival (RFS) for BTC patients. Methods: Individual patient data were retrieved from ABC -01, -02, -03, -04, and BILCAP study. AEs were graded according to National Cancer Institute's Common Toxicity Criteria v 4.02 and odds ratios along with 95%CI and p-values derived from l
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Ika Indrieaswati, Ika Indrieaswati, Rosalina Rosina Mirino, and Khristian Enggar Pamuji. "Studi Kelayakan Lokasi Tempat Pembuangan Akhir (TPA) Sampah Di Distrik Oransbari Kabupaten Manokwari Selatan Berdasarkan Bebarapa Parameter Fisik." Jurnal Natural 18, no. 2 (2022): 104–14. http://dx.doi.org/10.30862/jn.v18i2.191.

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This study was aimed to determine the feasibility level of the final disposal site (TPA) based on physical aspects in the Oransbari District according to SNI 19-3241-1994 and SNI 03-3241-1994. The method used is descriptive with field observation techniques. Measurement starts from the groundwater level using geoelectric mapping: Types of rock and distance to faults based on geological maps: slope, distance to rivers, distance to shoreline, and distance to airports based on topographic maps; rainfall data from BMKG; flooded and protected areas. Based on the results of the analysis of 10 physic
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7

Ahmed, Talal, Mark Carty, Kaveri Nadhamuni, and Raphael Pelossof. "Abstract PO5-24-03: Breast cancer intrinsic subtypes predict outcomes in primary and metastatic samples." Cancer Research 84, no. 9_Supplement (2024): PO5–24–03—PO5–24–03. http://dx.doi.org/10.1158/1538-7445.sabcs23-po5-24-03.

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Abstract Background: The prognostic and predictive value of the PAM50 intrinsic subtypes, namely Luminal A, Luminal B, Her2, and Basal-like subtypes, is well-studied in primary as well as metastatic breast cancer settings. Prosigna has emerged as a rapid PAM50 subtype predictor based on the NanoString nCounter assay. However, assay reproducibility across various RNASeq or qRT-PCR platforms can be challenging, especially when applying the predictor on metastatic breast cancer tumors. Here, we used SpinAdapt to create an intrinsic subtype predictor that works on RNA sequencing data, and validate
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Norris, Sarah Michelle, Eric Bombardier, Ian Curtis Smith, Chris Vigna, and Allan Russell Tupling. "ATP consumption by sarcoplasmic reticulum Ca2+ pumps accounts for 50% of resting metabolic rate in mouse fast and slow twitch skeletal muscle." American Journal of Physiology-Cell Physiology 298, no. 3 (2010): C521—C529. http://dx.doi.org/10.1152/ajpcell.00479.2009.

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In this study, we aimed to directly quantify the relative contribution of Ca2+ cycling to resting metabolic rate in mouse fast-twitch (extensor digitorum longus, EDL) and slow-twitch (soleus) skeletal muscle. Resting oxygen consumption of isolated muscles (V̇o2, μl·g wet wt−1·s−1) measured polarographically at 30°C was ∼25% higher in soleus (0.61 ± .03) than in EDL (0.46 ± .03). To quantify the specific contribution of Ca2+ cycling to resting metabolic rate, cyclopiazonic acid (CPA), a highly specific inhibitor of sarco(endo)plasmic reticulum Ca2+ ATPases (SERCAs), was added to the bath at dif
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9

Calvo Caravaca, Alfonso Luis, and María Pilar Canedo Arrillaga. "Casos escogidos de Derecho antitrust europeo." Estudios de Deusto 54, no. 1 (2014): 285. http://dx.doi.org/10.18543/ed-54(1)-2006pp285-373.

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Caso N.º 1. Ententes: Dec.Com. 7 abril 2004, Société Air France/Alitalia Linee Aeree Italiane SpA, DO L 362 de 9 diciembre 2004 Caso N.º 2. Ententes: STJCE 29 abril 2004, C-359/01 P, British Sugar plc/Comisión Caso N.º 3. Ententes: STPI de 29 de abril de 2004, Tokai carbón Co. Ltd y otros/Comisión de las Comunidades Europeas As. T-236/01, T-239/01, T-244/01, T-245/01, T-246/01, T-251/01 y T-252/01 Caso N.º 4. Ententes: Sentencia del Tribunal de Primera Instancia 15 junio 2005, Graphites spéciaux, As. T-71/03, T-74/03, T-87/03 y T-91/03 Caso N.º 5. Ententes: STPI 8 julio 2004, Mannesmannröhren-
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Ortiz, Martín Ruiz, Javier Muñiz, María Asunción Esteve-Pastor, et al. "Direct Anticoagulants Versus Vitamin K Antagonists in Patients Aged 80 Years or Older With Atrial Fibrillation in a “Real-world” Nationwide Registry: Insights From the FANTASIIA Study." Journal of Cardiovascular Pharmacology and Therapeutics 25, no. 4 (2020): 316–23. http://dx.doi.org/10.1177/1074248420916316.

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Objective: To describe major events at follow up in octogenarian patients with atrial fibrillation (AF) according to anticoagulant treatment: direct oral anticoagulants (DOACs) versus vitamin K antagonists (VKAs). Methods: A total of 578 anticoagulated patients aged ≥80 years with AF were included in a prospective, observational, multicenter study. Basal features, embolic events (stroke and systemic embolism), severe bleedings, and all-cause mortality at follow up were investigated according to the anticoagulant treatment received. Results: Mean age was 84.0 ± 3.4 years, 56% were women. Direct
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11

Hochhaus, A., S. Branford, J. Radich, et al. "Efficacy of dasatinib in chronic phase chronic myelogenous leukemia patients after imatinib failure according to baseline BCR- ABL mutations." Journal of Clinical Oncology 25, no. 18_suppl (2007): 7023. http://dx.doi.org/10.1200/jco.2007.25.18_suppl.7023.

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7023 Background: Dasatinib is an oral, multi-targeted BCR-ABL and SRC kinase inhibitor with preclinical activity against 20/21 imatinib (Im) resistant BCR-ABL mutations. Clinical efficacy was demonstrated in phase I, II, and III studies in patients (pts) with chronic myelogenous leukemia (CML) in all phases of the disease and BCR-ABL positive acute lymphoblastic leukemia (ALL). We sought to establish a relationship between type of BCR-ABL mutations associated with Im resistance and efficacy of dasatinib in chronic phase (CP) CML pts. Methods: Between 10/03 and 03/06, dasatinib was commenced in
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12

Bychkovsky, Brittany L., Min-Tzu Lo, Amal Yussuf, et al. "Abstract P2-09-03: Pathogenic variants among female breast cancer patients with a subsequent cancer demonstrate preventable cancer burden." Cancer Research 82, no. 4_Supplement (2022): P2–09–03—P2–09–03. http://dx.doi.org/10.1158/1538-7445.sabcs21-p2-09-03.

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Abstract Background: Among females with breast cancer, multiple primary cancers (MPCs) are a hallmark of cancer predisposition syndromes. Herein we report the frequency of germline pathogenic/likely pathogenic variants (PVs) among females with breast cancer (BC) and primary cancer of >1 other site who underwent multi-gene panel testing (MGPT) through a single lab. Among females first diagnosed with BC who had a PV in an actionable gene, we quantified the frequency of subsequent breast and non-breast cancers. Among those who later developed a second BC, ovarian, endometrial or colon canc
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13

Polevoy, Georgiy Georgievich. "Stributing the Attention of Schoolchildren and Its Development with the Help of Classical Exercises." Bangladesh Journal of Medical Science 22, no. 3 (2023): 604–11. http://dx.doi.org/10.3329/bjms.v22i3.66966.

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Objective: to determine the influence of Classical exercises on the distribution of attention of schoolchildren.
 Method: the pedagogical experiment was conducted during the academic year. It was attended by students aged 9-10 years (40 people). Coordination abilities were determined by the “Shuttle Run” test, and the distribution of students’ attention by the “Different counting” method. Statistical processing of the results was carried out according to the Bio-Stat program and the T-student was calculated.
 Results: after the experiment, the indicators in the control group improved
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14

Lau, Steven, Amit G. Singal, Adam Charles Yopp, Jeffrey John Meyer, Daniella Hall, and Michael Ryan Folkert. "Radiation therapy for palliation of osseous metastasis from hepatocellular carcinoma." Journal of Clinical Oncology 34, no. 26_suppl (2016): 204. http://dx.doi.org/10.1200/jco.2016.34.26_suppl.204.

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204 Background: Osseous metastasis from hepatocellular carcinoma (HCC) is uncommon, and optimal palliative management for palliation is unclear. We present our clinical experience with palliative radiotherapy (RT) for osseous metastasis from HCC. Methods: Patients were identified using two prospectively maintained databases at our institution: all patients with HCC who developed metastases and all patients undergoing RT. Medical records were retrospectively reviewed following Institutional Review Board approval. We identified 146 patients with metastatic HCC, of which 28 patients with 38 osseo
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Tang, Paul K., Peter Lepping, Sophie G. Lepping, et al. "PS02 Efficacy of antipsychotics in delusional infestation." British Journal of Dermatology 191, Supplement_1 (2024): i176. http://dx.doi.org/10.1093/bjd/ljae090.373.

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Abstract The 2022 British Association of Dermatologists’ (BAD) guidelines suggest the use of low doses of second-generation antipsychotics as the first-line pharmacological treatment option for adults with delusional infestation (DI). We evaluated the treatment responses associated with different antipsychotics in patients with DI. We undertook a multicentre, retrospective observational study using anonymized electronic patient records from two hospitals in the UK from 1 January 2011 to 1 January 2023. Eligible participants were adults (≥ 18 years) diagnosed with DI treated with an antipsychot
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García-García, María de Lourdes, Aida Jiménez-Corona, María Eugenia Jiménez-Corona, et al. "Factors Associated With Tuberculin Reactivity in Two General Hospitals in Mexico." Infection Control & Hospital Epidemiology 22, no. 02 (2001): 88–93. http://dx.doi.org/10.1086/501869.

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Abstract Objective: To identify risk factors associated with tuberculin reactivity in healthcare workers (HCWs). Design: Cross-sectional survey of tuberculin reactivity (2 TU of purified protein derivative (PPD) RT23, using the Mantoux two-step test). Setting: Two general hospitals located in a region with a high prevalence of tuberculosis and high bacille Calmette-Guérin (BCG) coverage. Participants: Volunteer sample of HCWs. Results: 605 HCWs were recruited: 71.2% female; mean age, 36.4 (standard deviation [SD], 8.2) years; 48.9% nurses, 10.4% physicians, 26.8% administrative personnel; mean
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Hernández-Cruz, B., M. J. Miranda García, J. Barrera, et al. "AB1030 PATIENT CARE AT THE FRACTURE LIAISON SERVICE REDUCE THE GAP IN THE TREATMENT OF OSTEOPOROSIS BETWEEN MEN AND WOMEN." Annals of the Rheumatic Diseases 81, Suppl 1 (2022): 1638–39. http://dx.doi.org/10.1136/annrheumdis-2022-eular.4150.

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BackgroundOsteoporosis (OP) between men and women is different,and the way it is treated also differs. In men, the gap in clinical care, especially diagnosis and treatment, is worse.ObjectivesTo analyze the differences in the clinical characteristics of OP (demographics, comorbidities, diagnosis, and treatment) in an gold star Fracture Liaison Service (FLS).MethodsDesign: Observational, prospective, analytical study of usual clinical practice. All patients treated from an FLS from May 2018 to August 2021 were prospectively included. Of each patient, 160 clinical variables were introduced in a
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Chiến, Võ Đức, Phan Trọng Lân, Nguyễn Thị Thi Thơ, Lương Công Minh та Võ Châu Duyên. "Thực trạng hoạt động công tác xã hội ở một số bệnh viện công lập hạng 1 tại Thành phố Hồ Chí Minh năm 2024". Tạp chí Y học Dự phòng 34, № 5 Phụ bản (2024): 138–45. http://dx.doi.org/10.51403/0868-2836/2024/1867.

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Hoạt động công tác xã hội (CTXH) trong các bệnh viện là một trong những hoạt động cần thiết. Với mục tiêu đánh giá thực trạng hoạt động CTXH tại 03 bệnh viện đa khoa công lập hạng I tại thành phố Hồ Chí Minh (TP.HCM), tiến hành nghiên cứu sử dụng phương pháp cắt ngang mô tả, có 242 nhân viên y tế và 230 người bệnh được chọn tham gia nghiên cứu bằng phương pháp chọn mẫu nhiều bậc. Người đủ tiêu chuẩn tham gia sẽ được phỏng vấn bằng bộ câu hỏi cấu trúc soạn sẵn. Nghiên cứu ghi nhận số nhân viên chuyên ngành CTXH có tỉ lệ thấp dưới 40%, tỷ lệ nhân viên tham gia mạng lưới CTXH chiếm 3,4 - 4,1%. Tỉ
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Vučajnk, Filip, Valentina Spanic, Stanislav Trdan, Iztok Jože Košir, Miha Ocvirk, and Matej Vidrih. "Performance of Symmetric Double Flat Fan Nozzles against Fusarium Head Blight in Durum Wheat." Agriculture 14, no. 3 (2024): 343. http://dx.doi.org/10.3390/agriculture14030343.

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Four types of nozzles were tested on large-scale trials with a 40 m2 plot unit size. The Avi Twin 110-01 (80 L ha−1), 110-02 (160 L ha−1), 110-03 (240 L ha−1), and 110-04 (320 L ha−1) symmetric double fan injector nozzles were tested during the 2020/2021 and 2021/2022 growing seasons. This study aimed to evaluate the performance of spray nozzles with regard to deoxynivalenol (DON) accumulation in durum wheat grains. Artificial inoculation with Fusarium spp. was performed after durum heads were protected with fungicide. The percentage of heads covered with fungicide droplets, grain yield, yield
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Frolov, S. V., L. O. Scherbakova, N. V. Moroz, V. N. Irza, and V. Yu Kulakov. "Comparative testing of vaccines based on viruses of genetic lineages G1 and Y280 for their potency against low pathogenic avian influenza H9N2." Veterinary Science Today, no. 3 (August 17, 2021): 224–29. http://dx.doi.org/10.29326/2304-196x-2021-3-38-224-229.

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Due to the genetic diversity of low pathogenic avian influenza (LPAI) viruses of subtype H9N2, it deemed appropriate to study the potency of the vaccines based on the antigens of strains А/chicken/Amursky/03/12 and A/chicken/Chelyabinsk/314-1/20 that represent currently circulating in the Russian Federation genetic lineages Y280 and G1, respectively. While low pathogenicity of the agent does not allow demonstrating the vaccine protective properties by the direct methods generally used for potency assessment (e.g. morbidity and mortality), the indirect methods were used: determination of antige
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Egger, Anthony C., Anas Minkara, Richard Parker, and James Rosneck. "Intra-articular Hip Injuries in National Basketball Association Players: A Descriptive Epidemiological Study." Orthopaedic Journal of Sports Medicine 10, no. 9 (2022): 232596712211227. http://dx.doi.org/10.1177/23259671221122744.

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Background: Since the most recent epidemiologic study of injuries in National Basketball Association (NBA) players was completed in 2012, the understanding and diagnosis of intra-articular hip injury has advanced. Purpose: To report the epidemiology of intra- versus extra-articular hip injuries in NBA players with regard to missed games, risk factors for injury, and treatment types. Study Design: Cohort study; Level of evidence, 3. Methods: The NBA injury database was queried for all reported hip and groin injuries from 2013 to 2017. The injuries were then divided into intra-articular and extr
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Ruíz-Giménez, Nuria, Carmen Suárez, Rocío González, et al. "Predictive variables for major bleeding events in patients presenting with documented acute venous thromboembolism. Findings from the RIETE Registry." Thrombosis and Haemostasis 100, no. 07 (2008): 26–31. http://dx.doi.org/10.1160/th08-03-0193.

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SummaryA score that can accurately determine the risk of major bleeding during anticoagulant therapy may help to make decisions on anticoagulant use. RIETE is an ongoing registry of consecutive patients with acute venous thromboembolism (VTE). We composed a score to predict the risk for major bleeding within three months of anticoagulant therapy. Of 19,274 patients enrolled, 13,057 (67%) were randomly assigned to the derivation sample, 6,572 to the validation sample. In the derivation sample 314 (2.4%) patients bled (fatal bleeding, 105). On multivariate analysis, age >75 years, recent blee
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23

Vyayzenen, G., R. Dautov, A. Vyayzenen, D. Bolshakov, and N. Prodanov. "Vitamin nutrition of calves." Kormlenie sel'skohozjajstvennyh zhivotnyh i kormoproizvodstvo (Feeding of agricultural animals and feed production), no. 3 (March 1, 2020): 25–36. http://dx.doi.org/10.33920/sel-05-2003-03.

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Experimental studies have shown an increase in productivity, metabolic processes, the effectiveness of the use of nutrients and biologically active substances and the metabolic energy of diets, the health of heifers aged 1–6 months under the conditions of industrial technology of their rearing. Increasing the productivity of heifers is closely related to improving the nutrition system during all periods of rearing with the use of the vitamin complex Vitaminol in diets depending on their age and body weight. The highest effectiveness of rearing young animals has been established when using Vita
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Hoekstra, Jildou, Ana H. C. Guimarães, Frank W. G. Leebeek, et al. "Impaired fibrinolysis as a risk factor for Budd-Chiari syndrome." Blood 115, no. 2 (2010): 388–95. http://dx.doi.org/10.1182/blood-2009-03-211557.

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Abstract In Budd-Chiari syndrome (BCS), thrombosis develops in the hepatic veins or inferior vena cava. To study the relationship between hypofibrinolysis and BCS, we measured plasma levels of fibrinolysis proteins in 101 BCS patients and 101 healthy controls and performed a plasma-based clot lysis assay. In BCS patients, plasminogen activator inhibitor 1 (PAI-1) levels were significantly higher than in controls (median, 6.3 vs 1.4 IU/mL, P < .001). Thrombin-activatable fibrinolysis inhibitor and plasmin inhibitor levels were lower than in controls (13.8 vs 16.9 μg/mL and 0.91 vs 1.02 U/L,
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Medvedev, A. Yu, A. A. Vasiliev, Yu A. Guseva, V. G. Smetankina, and S. N. Figurak. "Efficiency of rearing Tenebrio molitor and Zophobas morio larvae as a source of feed protein." Glavnyj zootehnik (Head of Animal Breeding), no. 9 (August 25, 2023): 37–48. http://dx.doi.org/10.33920/sel-03-2309-04.

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The purpose of the work was to study the effectiveness of rearing larvae of Tenebrio molitor and Zophobas morio as a source of feed protein, as well as their chemical composition and amino acid characteristics, while improving the nutrient medium. It was found that the cultivation of Zophobas morio larvae for the production of feed protein is more eff ective than Tenebrio molitor larvae. At the age of 71 days, the average weight of Zophobas morio reached 387,0±8,24 mg, which was 238,8 mg more than that of the large Tenebrio molitor or 2,6 times (p < 0,001). There was a higher content of cru
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Vo, Minh Cong, Huu Kien Pham, and Minh Hien Nguyen. "Posterior Nasal Neurectomy In Treatment of Intractable Rhinitis: A Preliminary Series." Philippine Journal of Otolaryngology-Head and Neck Surgery 33, no. 1 (2018): 12–16. http://dx.doi.org/10.32412/pjohns.v33i1.15.

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Objective: To evaluate the efficacy and safety of posterior nasal neurectomy on the treatment of nasal congestion, rhinorrhea, sneezing, and post-nasal discharge in intractable rhinitis patients.
 Methods
 Design: Preliminary case series 
 Setting: Tertiary University Medical Center
 Participants: Ten (10) patients with intractable rhinitis underwent endoscopic posterior nasal neurectomy in both sides. Symptoms were compared pre- and post-operatively one month and one year after surgery using Visual Analog Scale (VAS) scores. Endoscopic pre- and one-month post-operative Lun
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Koay, Shiwen, Vincenzo Provitera, Ekawat Vichayanrat, et al. "Cardiovascular autonomic failure correlates with cutaneous autonomic denervation and patient symptoms in alpha-synucleinopathies." Journal of Neurology, Neurosurgery & Psychiatry 93, no. 9 (2022): e2.79. http://dx.doi.org/10.1136/jnnp-2022-abn2.17.

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IntroductionCardiovascular autonomic failure and neurogenic orthostatic hypotension (nOH) are common and disabling features of Parkinson’s disease (PD) and multiple system atrophy (MSA). Compared to PD, MSA is considered a primarily central alpha-synucleinopathy.AimTo characterise the relationship between cardiovascular autonomic failure and cutaneous autonomic and somatic innervation in early PD and MSA.MethodsFifty-five patients (37 PD, 18 MSA) within 2 years of motor onset underwent: 1) cardiovascular autonomic testing 2) plasma catecholamines 3) distal leg skin biopsies for quantification
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Schmitt, Wolfgang D., Paul Jank, Inga Hoffmann, et al. "Abstract P2-03-23: Retrospective evaluation of outcomes in a real-world, prospective cohort using EndoPredict: Results from the Charité registry." Cancer Research 83, no. 5_Supplement (2023): P2–03–23—P2–03–23. http://dx.doi.org/10.1158/1538-7445.sabcs22-p2-03-23.

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Abstract Background: EndoPredict is a prognostic and predictive gene expression assay that provides an EPclin risk score, which can be used to identify individuals with low enough risk of distant breast cancer recurrence that they may forgo chemotherapy. In clinical studies, EndoPredict has been validated to predict risk of distant recurrence up to 15 years and chemotherapy benefit. To date, real-world studies evaluating patient outcomes after prospective EndoPredict testing have been limited. Here, we report on outcomes collected via survey from patients enrolled in a registry created to gene
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Kim, Yeon JIn, Soo Yeon Chung, Byung Joo Chae, Jonghan Yu, Jeong Eon Lee, and Jai Min Ryu. "Abstract P2-14-03: Learning curve for Robotic assisted nipple sparing mastectomy: a single institution experience." Cancer Research 83, no. 5_Supplement (2023): P2–14–03—P2–14–03. http://dx.doi.org/10.1158/1538-7445.sabcs22-p2-14-03.

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Abstract Backgrounds/Aims: Nipple sparing mastectomy (NSM) is popularly performed as this surgical technique is oncological safety and better cosmetic outcomes. Robot assisted NSM (RANSM) is emerging because of its exceptional advantages: hidden incisions, high resolution, wider visualization and ergonomically moving. Although several studies reported that RANSM has shown a short learning curve, there were few reports about learning curve of this cutting-edge surgical technique. In this study, we reported the learning curve and feasibility of RANSM. Methods: A retrospective and prospective stu
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Zelizer, Sophia, Grace Gallagher, Emanuela Ferraro, et al. "Abstract P5-03-09: Evaluating Post-T-DXd Treatment Strategies in HER2-positive Metastatic Breast Cancer." Clinical Cancer Research 31, no. 12_Supplement (2025): P5–03–09—P5–03–09. https://doi.org/10.1158/1557-3265.sabcs24-p5-03-09.

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Abstract Background: Trastuzumab deruxtecan (T-DXd) is an antibody-drug conjugate (ADC) that has proven highly effective in the treatment of HER2-positive metastatic breast cancer (MBC). However, drug resistance and disease progression eventually occur in the majority of patients. A critical examination of treatment strategies in the post-T-DXd setting is imperative in order to appropriately care for patients with TDXd-resistant breast cancer. Methods: We retrospectively examined baseline characteristics and clinical outcomes for patients after they had received T-DXd for HER2-positive metasta
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McArthur, Heather, Hanna Tukachinsky, Alexa Schrock, et al. "Abstract PO2-16-03: ESR1 genomic alterations (GAs) and coexistent putative resistance alterations in comprehensive genomic profiling (CGP) of metastatic breast cancer (MBC)." Cancer Research 84, no. 9_Supplement (2024): PO2–16–03—PO2–16–03. http://dx.doi.org/10.1158/1538-7445.sabcs23-po2-16-03.

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Abstract Background: ESR1 mutations (ESR1mut) are an established biomarker of endocrine therapy (ET) resistance in patients (pts) with hormone receptor positive (HR+) MBC. Moreover, ESR1mut acquired in response to standard-of-care ET now confer access to novel ET recently approved by health authorities. However, the nuanced genomic landscape beyond the simple presence or absence of ESR1mut may be critically important. We report on detailed ESR1 GAs detected by tissue and liquid biopsies (TBx, LBx) and examine the prevalence of co-occurring GAs in other genes reported to confer intrinsic or acq
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Lubova, Valeriya Alexandrovna, Anna Leonidovna Shutikova, and Galina Nikolaevna Leonova. "Transmissible tick-borne infections in the south of the Far East." Sanitarnyj vrač (Sanitary Doctor), no. 9 (September 1, 2021): 33–41. http://dx.doi.org/10.33920/med-08-2109-03.

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Natural foci of tick-borne infections associated with tick-borne encephalitis virus (TBEV), borrelia (Borrelia burgdorferi sensu lato), including Borrelia miyamotoi, anaplasma, ehrlichia and rickettsia are widespread in the Primorsky Krai. The carriers of these pathogens are ixodid ticks. The population of Primorsky Krai meets with ticks in natural biotopes, as well as in anthropurgic foci. The aim of the study is to give a comparative assessment of the epizootic activity in the natural foci of transmissible tick-borne infections in the south of Primorsky Krai in the epidemic seasons of 2017–2
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Ostapenko, I. I., and A. A. Bryantsev. "PROSPECTS FOR THE DEVELOPMENT OF AGRO-TOURISM ON THE TERRITORY OF THE REPUBLIC OF KAZAKHSTAN." Bulletin of Kazakh Leading Academy of Architecture and Construction 93, no. 3 (2024): 36–49. http://dx.doi.org/10.51488/1680-080x/2024.3-03.

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This article discusses the potential for the development of agro-tourism, which is an industry of the national economy that requires significant investment. Agro-ecotourism is one of the most popular forms of modern recreational activity. Depending on their specific characteristics, natural and climatic conditions, and management practices, various countries of the world organize this activity in different ways. It has been determined in this work that recreational activities are based on agro-landscapes and natural recreational resources. A systematic approach was the basic methodological fou
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Elbagir, S., L. M. Diaz-Gallo, G. Grosso, et al. "POS0747 ANTI-PHOSPHATIDYLSERINE/PROTHROMBIN ANTIBODIES AND VASCULAR EVENTS ASSOCIATE POSITIVELY WITH HLA-DRB1*13 AND NEGATIVELY WITH HLA-DRB1*03 IN SLE." Annals of the Rheumatic Diseases 81, Suppl 1 (2022): 658.2–659. http://dx.doi.org/10.1136/annrheumdis-2022-eular.2243.

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BackgroundAnti-phosphatidylserine/prothrombin antibodies (anti-PS/PT) associate with thrombotic events (1). HLA-DRB1 alleles contribute to the occurrence of conventional antiphospholipid antibodies (aPL), including anti-beta2glycoprotein-I (beta2GPI) and anti-cardiolipin (CL) (2).ObjectivesWe investigated associations between anti-PS/PT and HLA-DRB1 alleles and thrombosis in patients with SLE. Conventional aPL were included for comparison.MethodsWe included 341 consecutive Swedish SLE patients, with information on general cardiovascular risk factors, including blood lipids, lupus anticoagulant
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Rigolon, Walkiria De Oliveira, Lisandra Príncepe, and Rodnei Pereira. "Condições de trabalho no início da docência: elementos constituintes e repercussões no desenvolvimento profissional (Working conditions at the beginning of teaching: constituent elements and repercussions on professional development)." Revista Eletrônica de Educação 14 (October 9, 2020): 4195117. http://dx.doi.org/10.14244/198271994195.

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e4195117This essay aims to problematize the relationship between work condition and professional insertion, considering that the elements that constitute teaching work conditions can have a negative impact on professional development, needing to be taken into account when investigating the phenomenon of evasion and career abandonment, especially by beginning teachers. Assuming that the career is a process of marking and incorporating individuals into the institutionalized practices and routines of the work teams, which depends on positive conditions to consolidate and that it is through the st
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Lee, Yoo Jin, Joon Ho Moon, In Hee Lee, et al. "Killer Cell Immunoglobulin-like Receptor Ligand Matching Determines the Post-Transplant High Risk Groups Among Patients with Permissive HLA Mismatch in Unrelated Donor Hematopoietic Cell Transplantation." Blood 128, no. 22 (2016): 4566. http://dx.doi.org/10.1182/blood.v128.22.4566.4566.

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Abstract Background: Human leukocyte antigen (HLA) matching between donor and recipient is a key part of successful allogeneic hematopoietic cell transplantation (allo-HCT). The HCT from the unrelated donor (UD) with one allele/antigen mismatch (MM) can be as beneficial as HCT from perfectly matched donor. For the remaining patients, the donors with permissive mismatches may be the option. In HLA-mismatched transplantation, the patient and donor can also be mismatched for their killer cell immunoglobulin-like receptor (KIR) ligands that recognize allotypic determinants shared by certain HLA cl
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Ja’afar, Siti Mariam, Hafizuddin Awang, and Azriani Ab Rahman. "Level of Knowledge on Sexual and Reproductive Health Among Youths in Southern Region of Peninsular Malaysia." International Journal of Human and Health Sciences (IJHHS) 5, no. 3 (2021): 315. http://dx.doi.org/10.31344/ijhhs.v5i3.281.

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Background: Premarital sexual activity is associated with low level of knowledge of sexual and reproductive health which gives less control over decision making pertaining to sexuality. Low understanding of sexual and reproductive health knowledge made adolescents unaware of the consequences of premarital sexual activity. This study aimed to describe the knowledge of sexual and reproductive health among youths in the state of Johor, in southern region of peninsular Malaysia.Materials and Methods: A crosssectional study was conducted in eleven health facilities in Johor state, Malaysia. The stu
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Bell, David R., J. Troy Blackburn, Anthony C. Hackney, Stephen W. Marshall, Anthony I. Beutler, and Darin A. Padua. "Jump-Landing Biomechanics and Knee-Laxity Change Across the Menstrual Cycle in Women With Anterior Cruciate Ligament Reconstruction." Journal of Athletic Training 49, no. 2 (2014): 154–62. http://dx.doi.org/10.4085/1062-6050-49.2.01.

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Context: Of the individuals able to return to sport participation after an anterior cruciate ligament(ACL) injury, up to 25% will experience a second ACL injury. This population may be more sensitive to hormonal fluctuations, which may explain this high rate of second injury. Objective: To examine changes in 3-dimensional hip and knee kinematics and kinetics during a jump landing and to examine knee laxity across the menstrual cycle in women with histories of unilateral noncontact ACL injury. Design Controlled laboratory study. Setting: Laboratory. Patients or Other Participants: A total of 20
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Brunelle, Cheryl L., Amanda W. Jung, Louisa H. Smith, et al. "Abstract P6-03-04: Ipsilateral infusions are not associated with increased risk of breast cancer-related lymphedema in patients enrolled in a prospective screening program." Cancer Research 83, no. 5_Supplement (2023): P6–03–04—P6–03–04. http://dx.doi.org/10.1158/1538-7445.sabcs22-p6-03-04.

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Abstract BACKGROUND: Patients treated for breast cancer (BC) who are at risk of breast cancer-related lymphedema (BCRL) have been instructed for decades to avoid venipuncture, injections and infusions in the extremity ipsilateral to BC treatment. These instructions are given in theory to prevent BCRL development, despite lack of supporting data. Given fear of BCRL is high amongst the population at risk, it has been found that patients heed this advice regardless of level of BCRL risk. It has been previously found that there is no association between blood draws or injections in the ipsilateral
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Wolfson, Julia A., Aviva A. Musicus, Cindy W. Leung, Ashley N. Gearhardt, and Jennifer Falbe. "Effect of Climate Change Impact Menu Labels on Fast Food Ordering Choices Among US Adults." JAMA Network Open 5, no. 12 (2022): e2248320. http://dx.doi.org/10.1001/jamanetworkopen.2022.48320.

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ImportanceThere is increasing interest in strategies to encourage more environmentally sustainable food choices in US restaurants through the use of menu labels that indicate an item’s potential impact on the world’s climate. Data are lacking on the ideal design of such labels to effectively encourage sustainable choices.ObjectiveTo test the effects of positive and negative climate impact menu labels on the environmental sustainability and healthfulness of food choices compared with a control label.Design, Setting, and ParticipantsThis randomized clinical trial used an online national US surve
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Hubbard-Turner, Tricia. "Lack of Medical Treatment From a Medical Professional After an Ankle Sprain." Journal of Athletic Training 54, no. 6 (2019): 671–75. http://dx.doi.org/10.4085/1062-6050-428-17.

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Context Despite the prevalence of ankle sprains and the potential for developing chronic ankle instability and ankle osteoarthritis, ankle sprains are often perceived as an innocuous injury. Objective To understand the initial management and treatment sought by patients after a lateral ankle sprain (LAS) and to identify any differences in subjective function and self-reported injury. Design Cross-sectional study. Setting Research laboratory. Patients or Other Participants A total of 175 participants with chronic ankle instability (73 men, 102 women; age = 20.9 ± 3.4 years, height = 173.5 ± 13.
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Macpherson, Alison K., and Michael J. Schull. "Penetrating trauma in Ontario emergency departments: a population-based study." CJEM 9, no. 01 (2007): 16–20. http://dx.doi.org/10.1017/s1481803500014688.

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ABSTRACT Background: There is a paucity of population-based research on health service utilization related to penetrating trauma in Canada, even though such trauma can result in serious injury or death, and gunshot wounds have been labelled the “the new public health issue.” Complete epidemiologic data, including emergency department (ED) visits and hospitalizations, for penetrating trauma is not available. The objective of this paper is to describe the epidemiology of ED visits for firearm-related and knife-related penetrating trauma in one Canadian province. Methods: All EDs in the province
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Ralph, Lauren, Rosalyn Schroeder, Shelly Kaller, Daniel Grossman, and M. Antonia Biggs. "Self-Managed Abortion Attempts Before vs After Changes in Federal Abortion Protections in the US." JAMA Network Open 7, no. 7 (2024): e2424310. http://dx.doi.org/10.1001/jamanetworkopen.2024.24310.

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ImportanceWith decreasing access to facility-based abortion in the US, an increase in self-managed abortion (SMA) using various methods is anticipated. To date, no studies have examined changes in SMA in the shifting policy landscape.ObjectiveTo estimate changes in SMA prevalence among the general US population from before to after the Supreme Court’s June 2022 decision overturning federal abortion protections.Design, Setting, and ParticipantsSerial cross-sectional surveys were administered throughout the US from December 10, 2021, to January 11, 2022, and June 14 to July 7, 2023. Participants
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Benavides-Villanueva, F., V. Calvo-Río, J. Loricera, J. Irure-Ventura, M. Lopez-Hoyos, and R. Blanco. "POS0131 RELATION BETWEEN COVID-19 AND ANCA VASCULITIS. STUDY IN A SINGLE UNIVERSITY HOSPITAL." Annals of the Rheumatic Diseases 82, Suppl 1 (2023): 284. http://dx.doi.org/10.1136/annrheumdis-2023-eular.3234.

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BackgroundAnti-neutrophil cytoplasmic antibodies (ANCA) associated vasculitis (AAV) is a small vessel vasculitis. Hallmarked by the presence of antibodies against antigens in cytoplasmic granules of neutrophils. Different microbiological agents and vaccines can trigger an AAV, including severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) infection and Coronavirus disease 2019 (COVID-19) vaccine.ObjectivesTo compare:a) proportion of positive ANCA (+ANCA) test in 2019 (COVID-19 pre-pandemic) vs 2021 (COVID-19 pandemic),b) clinical features andc) vasculitis activity between vasculitis rel
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Mesa-Chavez, Fernanda, Maria Grazia Razeti, Eva Blondeaux, et al. "Abstract P2-03-02: Fertility and ovarian function preservation in young women with breast cancer: A comparative analysis of two prospective cohort studies in Mexico and Italy." Clinical Cancer Research 31, no. 12_Supplement (2025): P2–03–02—P2–03–02. https://doi.org/10.1158/1557-3265.sabcs24-p2-03-02.

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Abstract Background: Due to their age and life stage, young women with breast cancer (YWBC) encounter distinct challenges related to their diagnosis and treatment. Unmet parity along with potential premature ovarian insufficiency represent a notable concern among this group of patients. Effective strategies to address this issue include fertility preservation techniques, as well as temporary ovarian suppression with gonadotropin-releasing hormone agonists (GnRHa) for ovarian protection during cytotoxic treatments. Here we report a comparative analysis of two prospective studies describing the
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Urbano-Ispizua, Alvaro, Salut Brunet, Mariano Monzo, et al. "Germline Polymorphisms Provide Strong Prognostic Information in Intermediate Risk Acute Myeloblastic Leukemia (AML)." Blood 104, no. 11 (2004): 398. http://dx.doi.org/10.1182/blood.v104.11.398.398.

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Abstract In this study we tested whether distinct patterns of functional genomic polymorphisms in genes involved in drug metabolic pathways (GSTT1, SULT1C2, CD-EX, TOP2A, SXR-1, SXR-2), DNA repair (XPD, XPA, XPG, ERCC1), angiogenesis (VEGF-1, VEGF-2), and multidrug resistance (MDR1-1, MDR1-2) predict clinical outcome in patients with AML. Two hundred adult patients ≤60 year-old with primary AML (M3 excluded), enrolled in the AML-99 protocol of the CETLAM group between November-98 and July-03, have been studied. Induction therapy consisted of idarubicin, intermediate dose ara-C (IDAC) and VP16.
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Aljehani, Mayada A., Jeffrey Bien, Jerry S. H. Lee, George A. Fisher, and Albert Y. Lin. "KRAS Sequence Variation as Prognostic Marker in Patients With Young- vs Late-Onset Colorectal Cancer." JAMA Network Open 6, no. 11 (2023): e2345801. http://dx.doi.org/10.1001/jamanetworkopen.2023.45801.

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ImportanceThe understanding of the association between KRAS sequence variation status and clinical outcomes in colorectal cancer (CRC) has evolved over time.ObjectiveTo characterize the association of age at onset, tumor sidedness, and KRAS sequence variation with survival among patients diagnosed with CRC.Design, Setting, and ParticipantsThis cross-sectional study used data extracted from the Surveillance, Epidemiology, and End Results database. Patients diagnosed with adenocarcinoma of the colon or rectum from 2010 through 2015 were included and were classified as having young-onset (YO) can
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García, Consuelo González, Ma Sol Durán, Jose Ramón Mayans, et al. "Epidemiological Study of Mutiple Myeloma In Spain: Efectiveness and Survival Analysis." Blood 116, no. 21 (2010): 5044. http://dx.doi.org/10.1182/blood.v116.21.5044.5044.

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Abstract Abstract 5044 Introduction: Epidemiological studies are the base to evaluate the efficiency of medical interventions in the interest of the public health. Updated epidemiological data and effectivenes in the daily clinical practice are needed in Multiple Myeloma (MM). Materials and Methods: Epidemiological retrospective, longitudinal, multicenter nation wide Spanish study of an historical cohort of patients with MM. Data from patients aged ≥ 18 years, with a MM Stage II or III, who received a treatment on a daily clinical practice (not in clinical trials) for MM in the September'03-Au
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Opoku Asare, Kennedy, Yannik Terhorst, Julio Vega, Ella Peltonen, Eemil Lagerspetz, and Denzil Ferreira. "Predicting Depression From Smartphone Behavioral Markers Using Machine Learning Methods, Hyperparameter Optimization, and Feature Importance Analysis: Exploratory Study." JMIR mHealth and uHealth 9, no. 7 (2021): e26540. http://dx.doi.org/10.2196/26540.

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Background Depression is a prevalent mental health challenge. Current depression assessment methods using self-reported and clinician-administered questionnaires have limitations. Instrumenting smartphones to passively and continuously collect moment-by-moment data sets to quantify human behaviors has the potential to augment current depression assessment methods for early diagnosis, scalable, and longitudinal monitoring of depression. Objective The objective of this study was to investigate the feasibility of predicting depression with human behaviors quantified from smartphone data sets, and
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Thomas, Abbey C., Mark Villwock, Edward M. Wojtys, and Riann M. Palmieri-Smith. "Lower Extremity Muscle Strength After Anterior Cruciate Ligament Injury and Reconstruction." Journal of Athletic Training 48, no. 5 (2013): 610–20. http://dx.doi.org/10.4085/1062-6050-48.3.23.

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Context: Quadriceps and hamstrings weakness occurs frequently after anterior cruciate ligament (ACL) injury and reconstruction. Evidence suggests that knee injury may precipitate hip and ankle muscle weakness, but few data support this contention after ACL injury and reconstruction. Objective: To determine if hip, knee, and ankle muscle weakness present after ACL injury and after rehabilitation for ACL reconstruction. Design: Case-control study. Setting: University research laboratory. Patients or Other Participants: Fifteen individuals with ACL injury (8 males, 7 females; age = 20.27 ± 5.38 y
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