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Journal articles on the topic '324.6/23/0941'

Author: Grafiati

Published: 26 July 2024

Last updated: 31 July 2025

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1

Ebens, Allen J., Leanne Berry, Yung-Hsiang Chen, et al. "A Selective PIM Kinase Inhibitor Is Highly Active In Multiple Myeloma: The Biology of Single Agent and PI3K/AKT/mTOR Combination Activity." Blood 116, no. 21 (2010): 3001. http://dx.doi.org/10.1182/blood.v116.21.3001.3001.

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Abstract Abstract 3001 PIM kinases co-regulate several important elements of the PI3K/AKT/mTOR pathway in myeloma cells (Munugalavadla V. et al., ASH 2010 submitted abstr.). In this study we show that pan-PIM inhibition suppresses growth in myeloma cell lines, xenografts, and primary patient samples, both as a single-agent as well acting synergistically in combination with PI3K, AKT, and mTOR inhibition. The PIM kinases are a family of 3 ser/thr growth factor- & cytokine-induced proteins hypothesized to have redundant survival and growth functions. Although PIM-1,2 have been noted as highl

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2

Tzschoppe, Petra. "Olympische und Paralympische Spiele in Leipzig 2012 – Das Scheitern der Bewerbung und die Folgen." Leipziger Sportwissenschaftliche Beiträge 61, no. 2 (2020): 23–43. https://doi.org/10.5771/0941-5270-2020-2-23.

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3

Барабаш, Юрій. "Проблеми розвитку українського конституціоналізму в аспекті забезпечення незалежності України". State Building and Local Government, SPEC22 (1 листопада 2022): 13–23. https://doi.org/10.31359/1993-0941-2022-1-13-23.

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У статті розглядаються етапи розвитку українського конституціоналізму на предмет виокремлення проблем його розвитку, що впливали на забезпечення незалежності країни. Встановлено, що на кожному етапі конституційно-правового реформування та зміни форми держави в країні виникали проблеми, що безпосередньо впливали на забезпечення незалежності країни і використовувались іншими державами, і переважно росією у її корисних цілях.

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4

Рабінович, Петро. "Львівській лабораторії прав людини – 25 років". State Building and Local Government, SPEC21 (2 грудня 2021): 13–23. https://doi.org/10.31359/1993-0941-2021-1-13-23.

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В статті розглядаються першопричини, обставини та історичний контекст створення Львівської лабораторії прав людини і громадянина у 1996 році на базі тогочасної Академії правових наук України. Окрему увагу в статті приділено детальному розгляду основних результатів дослідницької діяльності лабораторії протягом більше ніж 25 років існування та активності. В тексті представлено широкий спектр проведених досліджень, їх значення та вклад у формування та розвиток прав людини в Україні. В статті розкрито роль Львівської лабораторії прав людини і громадянина у процесі сприяння удосконаленню положень К

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5

Morales, José. "Santiago SANZ SÁNCHEZ, El futuro creador del Dios Trinitario. Un estudio en la Teología Sistemática de Wolfhart Pannenberg, Edicep, Valencia 2007, 221 pp., 16 x 23, ISBN 978-8-4705-0941-4." Scripta Theologica 41, no. 3 (2017): 1005. http://dx.doi.org/10.15581/006.41.13304.

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6

Wandler, Anica M., Benjamin Huang, Alessandro Scacchetti, et al. "Resistant T-Cell Acute Lymphoblastic Leukemias That Emerge after In Vivo Treatment with Dexamethasone Frequently Down-Regulate Glucocorticoid Receptor Protein Expression." Blood 128, no. 22 (2016): 753. http://dx.doi.org/10.1182/blood.v128.22.753.753.

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Abstract Acute lymphoblastic leukemia (ALL) is the most common childhood cancer, with T lineage ALL (T-ALL) accounting for approximately 20% of cases. Many T-ALL patients present with high risk clinical features, and receive aggressive multi-agent genotoxic therapies that pose a substantial risk of long-term adverse health effects. Glucocorticoids (GCs) are an integral part of current treatment strategies for T-ALL and other lymphoid cancers. Despite decades of clinical use, the molecular mechanisms underlying GC efficacy and resistance are incompletely understood. Limited initial response to

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7

Munugalavadla, Veerendra, Leanne Berry, Jae Chang та ін. "A Critical Role for PIM2 Kinase in Multiple Myeloma Through NF-κB Activation". Blood 118, № 21 (2011): 1839. http://dx.doi.org/10.1182/blood.v118.21.1839.1839.

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Abstract Abstract 1839 The PIM kinases are a family of 3 growth factor- & cytokine-induced proteins hypothesized to have redundant survival and growth functions. Although PIM-1, -2 have been noted as highly expressed in multiple myeloma (MM) (Claudio JO et al., 2002), there are few data to support potential therapeutic utility of PIM inhibition in this indication. Here we show that the myeloma cell lines express all PIM protein isoforms to varying extents, and we describe the properties of a novel pan-PIM inhibitor GNE-652 with picomolar biochemical potency, an excellent selectivity profil

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8

Trojani, V., A. Botti, M. Grehn, et al. "OC-0941 STereotactic Arrhythmia Radioablation in Europe: STOPSTORM Consortium Treatment Planning Benchmark." Radiotherapy and Oncology 182 (May 2023): S788—S790. http://dx.doi.org/10.1016/s0167-8140(23)08767-4.

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9

Cappelli, Barbara, Francoise Bernaudin, Annalisa Ruggeri, et al. "Hematopoietic Stem Cell Transplantation from HLA Identical Sibling Forsickle Cell Disease an International Survey on Behalf of Eurocord-Monacord, EBMT Paediatric Disease Working Party and CIBMTR." Blood 126, no. 23 (2015): 541. http://dx.doi.org/10.1182/blood.v126.23.541.541.

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Abstract Introduction: Hematopoietic stem cell transplantation (HSCT) is, to date, the only curative therapy for sickle cell disease (SCD). However, HSCT is offered to relatively few patients with SCD for a number of reasons including lack of a suitable HLA-matched donor, lack of consensus on indications for HSCT, the potential for trading one chronic condition (i.e., SCD) for another, such as chronic graft-versus-host disease (GVHD), and the mortality associated with the procedure. To-date, most HSCTs for SCD have utilized matched siblings as donors and are performed in children and adolescen

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10

Mali, Raghuveer, Holly Rene Martin, Baskar Ramdas, et al. "Novel Functional Roles for Ten-Eleven-Translocation 2 (Tet2) in Normal and Leukemic Growth of Mast Cells." Blood 126, no. 23 (2015): 775. http://dx.doi.org/10.1182/blood.v126.23.775.775.

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Abstract KIT receptor signaling plays an important role in mast cell development. Gain-of-function mutations in KIT receptor have been identified in human diseases including gastrointestinal stromal tumors (GIST), systemic mastocytosis (SM) and acute myeloid leukemia (AML). Although KIT mutations found in GIST are sensitive to imatinib, KIT mutation (KITD816V) found in 90% of SM patients is imatinib-resistant and currently no therapies are available to treat the human diseases associated with this mutation. Our recent studies have identified Ten-Eleven-Translocation 2 (TET2) mutations in ~23%

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11

Assmann, Richard, and Bartsch von Sigsfeld. "A new form of the Assman aspiration thermometer, demonstrated at the General Assembly of the German Meteorologial Society in Berlin, 23-25 April 1889." Meteorologische Zeitschrift 21, no. 4 (2012): 421–22. http://dx.doi.org/10.1127/0941-2948/2012/530.

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12

Костенко, Інеса. "Legal disputes and gaps in the context of space security legislation of Ukraine." State Building and Local Government, no. 45 (May 29, 2023): 363–81. https://doi.org/10.31359/1993-0941-2023-45-363.

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The article examines current gaps and inconsistencies in Ukrainian space and security law. The concept for the research was envisaged following the submission of the Draught Law on Amendments to the Law of Ukraine «On National Security of Ukraine» and the Law of Ukraine «On Space Activities» (No. 7485 dated June 23, 2022). Research and legal analysis are conducted within the framework of the specified draught law, taking into consideration the legal regulation experience of developed countries in the space field, namely the United States and the United Kingdom. The article provides a detailed

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13

Jordan, Stephen A., Daniel J. Mailhot, Amanda J. Gevens, et al. "Characterization of Kudzu (Pueraria spp.) Resistance to Phakopsora pachyrhizi, the Causal Agent of Soybean Rust." Phytopathology® 100, no. 9 (2010): 941–48. http://dx.doi.org/10.1094/phyto-100-9-0941.

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Kudzu (Pueraria spp.) is an accessory host for soybean rust (SBR) (caused by Phakopsora pachyrhizi) that is widespread throughout the southeastern United States. An expanded survey of kudzu sites was conducted in 2008 to determine the proportion of natural resistance in the north-Florida kudzu population. Of the 139 sites evaluated, ≈18% were found to be free of SBR infection, while 23% had reduced sporulation. Ten accessions of kudzu from north-central Florida were characterized for their response to challenge by a single isolate of P. pachyrhizi under laboratory conditions. Three outcomes we

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14

El-Khoueiry, Anthony B., Cathryn J. Rankin, Syma Iqbal, et al. "SWOG 0941: A phase II study of sorafenib and erlotinib in patients (pts) with advanced gallbladder cancer or cholangiocarcinoma." Journal of Clinical Oncology 30, no. 15_suppl (2012): 4113. http://dx.doi.org/10.1200/jco.2012.30.15_suppl.4113.

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4113 Background: The treatment of pts with advanced biliary cancers represents a therapeutic challenge. The vascular endothelial growth factor and epidermal growth factor receptor pathways play an important role in biliary carcinogenesis, as evidenced by their up-regulation and prognostic impact. Methods: The primary objective was progression free survival (PFS) (improvement in PFS from 4 to 8 months); secondary endpoints included overall survival (OS), objective response rate, and toxicity. A two-stage design was used; if 13 or more eligible pts of the 25 initially accrued were alive without

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15

Castillo-Cabrera, Javier, Mary Carmen Pacheco-Esteva, Brayan Ramos-Caballero, Guadalupe Arlene Mora-Romero, Karla Yeriana Leyva-Madrigal, and Alfonso Vásquez-López. "First Report of Colletotrichum chrysophilum Causing Anthracnose on Nance (Byrsonima crassifolia) in Mexico." Plant Disease, October 19, 2023. http://dx.doi.org/10.1094/pdis-05-23-0941-pdn.

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Nance fruit [Byrsonima crassifolia (L.) HBK] is a native crop widely distributed in Mexico and South America (Medina-Torres et al. 2018). It has been reported that nance is a good source of active compounds with anti-inflammatory, neuropharmacological and antioxidant effects. In 2022, the annual production of nance fruit in Mexico was of 7,713.13 tons and average yield of 5.64 t/ha with economic value of 51,952.66 million pesos (SIAP, 2022). This production generated significant economic income for the communities at a local, regional, and national level. In January 2023, irregular necrotic sp

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16

Qiu, Rui, Juan Li, Wenming Zheng, et al. "First Report of Root Rot of Tobacco Caused by Fusarium brachygibbosum in China." Plant Disease, May 18, 2021. http://dx.doi.org/10.1094/pdis-01-21-0077-pdn.

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Tobacco (Nicotiana tabacum L.) is an important cash crop in China, with an estimated production of 2.2 million tons every year (Berbeć and Matyka, 2020). In June 2020, a root rot disease was observed on tobacco (cv. Zhongyan 100) in four surveyed counties (Mianchi, Lushi, Duguan and Lingbao) in Sanmenxia. Diseased plants exhibited leaf chlorosis and purplish to brown vascular discoloration of stem, taproot and lateral roots. The disease incidence ranged from 15% to 40% in 11 surveyed fields, 36.7 ha in total. Twenty five diseased tissues were surface sterilized in 75% ethanol and placed on pot

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