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Journal articles on the topic '332.74 (477-25) (043.2)'

Author: Grafiati

Published: 30 May 2022

Last updated: 31 July 2025

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1

Adinolfi, A., S. Sirotti, G. Sakellariou, et al. "POS1141 ASSESSING RELEVANT JOINTS FOR MONITORING CPPD DISEASE: A SYSTEMATIC LITERATURE REVIEW OF IMAGING TECHNIQUES BY THE OMERACT ULTRASOUND – CPPD SUBGROUP." Annals of the Rheumatic Diseases 80, Suppl 1 (2021): 850.1–850. http://dx.doi.org/10.1136/annrheumdis-2021-eular.3153.

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Background:Imaging has been extensively used for the Calcium Pyrophosphate Deposition Disease (CPPD) diagnosis but the prevalence of joint calcifications at imaging in CPPD patients has not been thoroughly assessed.Objectives:This systematic literature review (SLR) is aimed to estimate the prevalence of calcium crystal deposition in peripheral joints by imaging in suspected or definite CPPD patients to establish relevant joints for CPPD monitoringMethods:After defining PICOs, Pubmed and Embase were searched from inception to October 2020 for identifying studies that evaluated the use of Conven

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Reeder, C. B., T. E. Witzig, P. L. Zinzani, et al. "Efficacy and safety of lenalidomide oral monotherapy in patients with relapsed or refractory mantle-cell lymphoma: Results from an international study (NHL-003)." Journal of Clinical Oncology 27, no. 15_suppl (2009): 8569. http://dx.doi.org/10.1200/jco.2009.27.15_suppl.8569.

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8569 Introduction: Relapsed or refractory MCL patients demonstrated a promising overall response rate (ORR) of 53% with a median duration of response (DR) of 13.7 months to single-agent lenalidomide when analyzed as a subset in a recent a phase II study (NHL-002). A supporting international phase II trial (NHL-003) of single-agent lenalidomide was initiated for patients with relapsed or refractory aggressive NHL. In this report, we analyze the current results from the MCL patients enrolled in this trial. Methods: Patients with relapsed or refractory MCL and measurable disease 2 cm after at lea

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Tsuji, H., R. Nakashima, T. Sasai, et al. "POS0142 THE ASSOCIATION OF AUTOANTIBODIES WITH CLINICAL MANIFESTATIONS AND LONG-TERM REMISSIONS IN COMPARISON WITH JUVENILE- AND ADULT-ONSET IDIOPATHIC INFLAMMATORY MYOPATHIES." Annals of the Rheumatic Diseases 82, Suppl 1 (2023): 291–92. http://dx.doi.org/10.1136/annrheumdis-2023-eular.323.

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BackgroundThe associations of myositis-specific autoantibodies (MSAs) and myositis-associated autoantibodies (MAAs) with clinical features and remission in idiopathic inflammatory myopathy (IIM) are different between those of juvenile-onset (JIIM) and adult-onset.ObjectivesSince the associations in JIIM had not been fully elucidated, we analyzed them comparing that in adults using clinical information and autoantibodies.MethodsA total of 320 cases of IIMs (juvenile-onset, 2004-2021, n=34; adult-onset, 2018-2021, n=286) with a history of attendance at our hospital were retrospectively analyzed

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Liao, Wei, Matthew Paul Smeltzer, Jordan Goss, et al. "Lung cancer diagnosis rates (LCDR) in lung cancer screening (LCS) and incidental pulmonary nodule (IPN) cohorts in the Mississippi Delta." Journal of Clinical Oncology 43, no. 16_suppl (2025): 8002. https://doi.org/10.1200/jco.2025.43.16_suppl.8002.

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8002 Background: The LCDR in the CT screened cohort in the National Lung Screening Trial (NLST) was 1.1% over a median of 6.5 years follow up. We evaluated the LCDR in a regional US community. Methods: Prospective cohort study of patients in LCS and IPN programs in 22 facilities across a 125 county service area population. We compared LCDR over 3 years in LCS stratified by Lung-RADS (L-R) score (1 to 4X), IPN by nodule size (≤6, >6-15, >15-20, >20-30 mm) on initial CT scans. Comparisons used Chi-square tests, Wilcoxon tests, and Cox regression models with Hazard Ratios (HR) for lung c

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Khoo, Joan, Christoph E. Hagemeyer, Darren C. Henstridge, et al. "Effects of water stably-enriched with oxygen as a novel method of tissue oxygenation on mitochondrial function, and as adjuvant therapy for type 2 diabetes in a randomized placebo-controlled trial." PLOS ONE 16, no. 7 (2021): e0254619. http://dx.doi.org/10.1371/journal.pone.0254619.

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Background Diabetes mellitus is associated with inadequate delivery of oxygen to tissues. Cellular hypoxia is associated with mitochondrial dysfunction which increases oxidative stress and hyperglycaemia. Hyperbaric oxygenation therapy, which was shown to improve insulin sensitivity, is impractical for regular use. We evaluated the effects of water which is stably-enriched with oxygen (ELO water) to increase arterial blood oxygen levels, on mitochondrial function in the presence of normal- or high-glucose environments, and as glucose-lowering therapy in humans. Methods We compared arterial blo

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Sasaki, Koji, Ildefonso Ismael Rodriguez-Rivera, Hagop M. Kantarjian, et al. "Correlation of Lymphocyte Count with Treatment Response to Tyrosine Kinase Inhibitors in Newly Diagnosed Chronic Myeloid Leukemia in Chronic Phase." Blood 124, no. 21 (2014): 4538. http://dx.doi.org/10.1182/blood.v124.21.4538.4538.

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Abstract Background: Total lymphocyte count (TLC) has been shown to correlate with outcomes in patients (pts) with acute leukemia. The clinical correlation to TLC in pts with chronic myeloid leukemia in chronic phase (CML-CP) who were treated with a tyrosine-kinase inhibitor (TKI) is unclear. Methods: Lymphocyte data in pts with newly diagnosed CML-CP who were enrolled in consecutive or parallel clinical trials with front-line imatinib (IM), nilotinib (Nilo), or dasatinib (Dasa) were collected at the time of diagnosis, and 3 and 6 months (M) after the start of TKI. Relative lymphocytrosis (RLC

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Rashidzadeh, Hamid, Mahsa Salimi, Somayeh Sadighian, Kobra Rostamizadeh, and Ali Ramazani. "In vivo Antiplasmodial Activity of Curcumin-Loaded Nanostructured Lipid Carriers." Current Drug Delivery 16, no. 10 (2019): 923–30. http://dx.doi.org/10.2174/1567201816666191029121036.

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Background: It was shown that curcumin (Cur) has anti-plasmodium activity, however, its weak bioavailability, rapid metabolism, and limited chemical stability has restricted its application in clinical usages. Nanostructured lipid carriers (NLCs) are a type of drug-delivery systems (DDSs) which their core matrix is composed of both solid and liquid lipids. Objective: The aim of the current study was to prepare and characterize curcumin-loaded nanostructured lipid carriers (Cur-NLC) for malaria treatment. Methods: For the production of NLC, coconut oil and cetyl palmitate were selected as a liq

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Kloner, Robert A., Coleman Gross, Jinwei Yuan, Ansgar Conrad, and Pablo E. Pergola. "Effect of Patiromer in Hyperkalemic Patients Taking and Not Taking RAAS Inhibitors." Journal of Cardiovascular Pharmacology and Therapeutics 23, no. 6 (2018): 524–31. http://dx.doi.org/10.1177/1074248418788334.

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Introduction: Hyperkalemia (potassium >5.0 mEq/L) affects heart failure patients with renal disease regardless of the use of renin–angiotensin–aldosterone system inhibitors (RAASi). The open-label TOURMALINE study showed that patiromer, a sodium-free, nonabsorbed potassium binder, lowers serum potassium of hyperkalemic patients similarly when given with or without food; unlike prior studies, patients were not required to be taking RAASi. We conducted post hoc analyses to provide the first report of patiromer in patients not taking RAASi. Methods: Hyperkalemic patients received patiromer, 8.

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Trentin, F., C. Tani, A. Cauli, et al. "AB0558 ANIFROLUMAB IN REFRACTORY SYSTEMIC LUPUS ERYTHEMATOSUS: A REAL-LIFE, MULTICENTER STUDY." Annals of the Rheumatic Diseases 82, Suppl 1 (2023): 1476. http://dx.doi.org/10.1136/annrheumdis-2023-eular.3552.

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BackgroundAnifrolumab (ANI) is a monoclonal antibody to the type I interferon receptor recently approved by EMA as an add-on therapy for the treatment of moderate to severe SLE. As of this writing, real world data on its use are still lacking.ObjectivesTo depict the clinical phenotype of refractory SLE patients treated with ANI. To evaluate short-term effectiveness and safety of ANI in clinical practice.MethodsMulticenter prospective cohort study on adult patients with SLE treated with ANI for compassionate use. Demographic data, clinical and treatment history, and SLICC Damage Index (SDI) wer

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Abou Alaiwi, Sarah, Dylan J. Martini, Wanling Xie, et al. "Safety and efficacy of restarting immune checkpoint inhibitors (CPI) after immune-related adverse events (irAEs) in metastatic renal cell carcinoma (mRCC)." Journal of Clinical Oncology 37, no. 7_suppl (2019): 652. http://dx.doi.org/10.1200/jco.2019.37.7_suppl.652.

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652 Background: CPI can induce a range of irAEs with various degrees of severity. Clinical experience with retreatment following clinically significant irAEs is growing. Methods: We retrospectively reviewed mRCC patients treated with CPI-based regimens who had >1 week therapy delay for irAEs at Dana Farber and Emory to characterize the safety and outcomes of retreatment. Toxicity was graded by CTCAEv5. Patients were divided into retreatment (R) and discontinuation (D) cohorts. Patient characteristics were compared by Fisher’s exact test or Wilcoxon’s rank sum test. ORR, OS and PFS were asse

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Demuth, Lukas, Carson Patterson, Franz F. Locker, and Christian Raschner. "Force-velocity profiling in elite luge athletes during the simulated luge start." Current Issues in Sport Science (CISS) 9, no. 4 (2024): 020. http://dx.doi.org/10.36950/2024.4ciss020.

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Introduction & Purpose The idea of some athletes having high strength levels but being too slow for a particular movement while others are fast but not strong enough for the demands of their sport exists among many coaches. Therefore, planning decisions are often based on the measurement results of speed and force capabilities and the interest in the relationships between additional load, force, velocity and power during the required movement is high. The luge start is a ballistic movement that requires both high forces and velocities to reach maximal performance (i.e. fast starting times)

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Batpen, Arman, Mukhtar Abilmazhinov, Kairat Tazhin, and Аblaikhan Кazbekov. "Evaluation of the effectiveness of a differential approach to the treatment of chest deformities." Traumatology and Orthopаedics of Kazakhstan 3, no. 74 (2024): 46–54. https://doi.org/10.52889/1684-9280-2023-3-74-46-54.

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Currently, the issue of treating chest deformities remains relevant due to their variability. The aim of this study was to analyze the results of treatment of patients with various chest deformities for the period from 2010 to 2022.Methods. During the period from 2010 to 2022, 347 patients with chest deformities were operated in the Orthopedics Department No.2 of the National сenter of traumatology and orthopedics named after Academician N.D. Batpenov: 230 patients with funnel–shaped deformity (66.3%), 70 patients with keel-shaped deformity (20.2%), 15 with local deformities patients (4.3%), w

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El-Najjar, Inas, Janet Matthews, John Gribben, and Silvia Montoto. "Neither the FLIPI Nor the FLIPI2 Accurately Segregates Low- Risk From Intermediate- Risk Follicular Lymphoma Patients in Terms of Progression-Free Survival." Blood 118, no. 21 (2011): 2663. http://dx.doi.org/10.1182/blood.v118.21.2663.2663.

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Abstract Abstract 2663 Background: Follicular Lymphoma International Prognostic Index (FLIPI) is the most frequently used prognostic index for risk stratification in follicular lymphoma (FL) patients. The FLIPI was designed retrospectively in the pre-rituximab era, with overall survival (OS) as the end-point. Follicular Lymphoma International Prognostic Index 2 (FLIPI2) is a more recent index designed prospectively in the rituximab era to overcome these drawbacks. Aim: To compare the efficacy of the FLIPI and FLIPI2 prognostic indexes in discriminating patients with FL with a distinct outcome

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Mahipal, Amit, Emily Teslow, Yingying Yu, et al. "Molecular characteristics of early-onset versus average-onset gastroesophageal adenocarcinoma." Journal of Clinical Oncology 43, no. 4_suppl (2025): 496. https://doi.org/10.1200/jco.2025.43.4_suppl.496.

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496 Background: Incidence of early-onset gastroesophageal adenocarcinoma (eoGEA, ages <50 years) has been increasing in the United States since the 1990s, the etiology of which is still unclear, and limited data exists on molecular drivers. This study evaluates somatic and germline profiles in eoGEA compared to average-onset GEA (aoGEA, ages≥ 50 years). Methods: This is a retrospective, cross-sectional study utilizing data from de-identified records of GEA (esophageal, gastroesophageal junction and gastric adenocarcinomas) patients who underwent somatic NGS testing via the Tempus xT assay (

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Rabaglio, Manuela, Daniel Dietrich, Bernhard Scheibe, et al. "Abstract P4-01-25: Safety analysis after 11 years of follow-up of the randomized phase III trial SAKK22/99: upfront chemotherapy in advanced HER2 positive breast cancer." Cancer Research 83, no. 5_Supplement (2023): P4–01–25—P4–01–25. http://dx.doi.org/10.1158/1538-7445.sabcs22-p4-01-25.

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Abstract Background: The SAKK 22/99 is a phase III randomized clinical trial launched by the Swiss Group for Clinical Cancer Research and the European Institute of Oncology in Milan in 99 for women with HER2-positive advanced breast cancer (ABC). 175 patients were randomized 1:1 from Sept 99 to Jan 2013 to receive first-line trastuzumab (T) alone followed at disease progression by the combination with chemo (Arm A) vs the upfront combination of T and chemo (Arm B). The results were published in 2017 (O. Pagani et al Ann Onc 28: 305–312, 2017). The outcome was similar for sequential T-chemo or

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Escamilla, Virginia, Jose Falantes, Cristina Calderon, et al. "Prognostic Impact of Adverse Karyotype and Treatment in Patients with Myelodysplastic Syndrome and Acute Myeloid Leukemia." Blood 126, no. 23 (2015): 5241. http://dx.doi.org/10.1182/blood.v126.23.5241.5241.

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Abstract INTRODUCTION Karyotype is a key prognostic factor in myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML). Adverse karyotype (AK) significantly influences on response to treatment, prognosis and survival in older MDS and AML patients(pts)1,2. AIMS Evaluate the frequency of adverse karyotype over the total number of patients (pts) diagnosed with MDS and AML in our institution, demographic features, treatment received and overall survival (OS) estimates. Second, to analyze prognostic factors associated to OS in this cohort of pts. PATIENTS AND METHODS A retrospective and obs

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Tsai, Charlton, Joanne F. Chou, Tiago Biachi de Castria, et al. "Predictors of resistance to trastuzumab deruxtecan (T-DXd) in esophagogastric adenocarcinoma (EGC)." Journal of Clinical Oncology 41, no. 16_suppl (2023): e16024-e16024. http://dx.doi.org/10.1200/jco.2023.41.16_suppl.e16024.

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e16024 Background: In DESTINY-Gastric01/02, T-DXd improved objective response rates (ORR) and overall survival (OS) relative to chemotherapy in patients (pts) with trastuzumab-refractory HER2+ EGC. We sought to identify clinicopathologic features that predict response and resistance to T-DXd, in a cohort from Memorial Sloan Kettering Cancer Center (MSKCC). Methods: Demographics of pts with HER2+ (HER2 IHC 3+ or IHC 2+/FISH+) advanced EGC at MSKCC treated with T-DXd in 2nd line or later (2L+) from 2017 to 2022 were reviewed via the medical record. Progression-free survival (PFS) and OS were cal

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Bollard, Catherine M., Stephen Gottschalk, Andrea M. Sheehan, et al. "Complete Tumor Responses in Lymphoma Patients Receiving Autologous Cytotoxic T Lymphocytes Targeting Epstein Barr Virus (EBV) - Latent Membrane Proteins." Blood 118, no. 21 (2011): 956. http://dx.doi.org/10.1182/blood.v118.21.956.956.

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Abstract Abstract 956 The tumor cells of EBV-associated Hodgkin's Lymphoma (HL) and of some non-Hodgkins lymphoma (NHL) express the subdominant EBV antigens LMP1 and LMP2 (Type II viral latency), and these may serve as target antigens for immunotherapy. We hypothesized that cytotoxic T lymphocytes (CTLs) enriched for effector cells specifically targeting LMP antigens would have efficacy in patients with EBV+ lymphoma. We prepared antigen presenting cells (dendritic cells for the initial stimulation, EBV- lymphoblastoid cell lines (LCLs) for the subsequent) that expressed transgenic and inactiv

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Mingoti, G. Z., F. Filion, P. Vincent, and L. C. Smith. "199 PREMATURATION OF BOVINE OOCYTES WITH BUTYROLACTONE I AND/OR CILOSTAMIDE: EFFECTS ON MEIOSIS PROGRESSION, CYTOPLASMIC MATURATION AND GENE EXPRESSION." Reproduction, Fertility and Development 24, no. 1 (2012): 212. http://dx.doi.org/10.1071/rdv24n1ab199.

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Meiotic block during a prematuration culture (pre-IVM) before in vitro maturation (IVM) is suggested as a way to provide additional time to synchronize oocyte-somatic cell communication, leading to improved cytoplasmic maturation and nuclear meiotic competence and the acquisition of critical cellular functions necessary for developmental competence. This study was designed to evaluate the effects of the inhibitors butyrolactone I (Bl-I) and cilostamide on oocyte nuclear and cytoplasmic maturation. For that, 2 well-established methods of pre-IVM and IVM for cilostamide (Albuz et al. 2010 Hum. R

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Costa, Luciano J., Geoffrey L. Uy, Parameswaran N. Hari, et al. "Contribution of Chemotherapy Mobilization to Disease Control in Multiple Myeloma Treated with Autologous Transplantation." Blood 124, no. 21 (2014): 2447. http://dx.doi.org/10.1182/blood.v124.21.2447.2447.

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Abstract Background: Autologous hematopoietic progenitor cells (auto-HC) can be mobilized either by hematopoietic growth factors (GF) alone or cytotoxic chemotherapy + GF (CC+GF). The latter is associated with higher CD34+ yields, but is associated with increased costs and risks of infection and hospitalization. In patients with multiple myeloma (MM) undergoing Auto-HCT, it is uncertain whether mobilization with CC+GF affects post transplant outcomes. Methods: We conducted a retrospective analysis of patients with MM undergoing their first AHPCT following high dose melphalan (≥140 mg/m2) betwe

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Weiß, A., C. Bungartz, J. Richter, et al. "AB0472 DISEASE ACTIVITY AND OUTCOME IN PREGNANCIES OF PATIENTS WITH SpA - DATA FROM THE GERMAN PREGNANCY REGISTER RHEKISS." Annals of the Rheumatic Diseases 80, Suppl 1 (2021): 1263–64. http://dx.doi.org/10.1136/annrheumdis-2021-eular.2087.

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Background:Spondyloarthritis (SpA) is a severe chronic inflammatory disease, which affects quality of life and functional status. It frequently occurs in women of childbearing age. Active disease and TNFi discontinuation at early pregnancy were found to be risk factors for flares during pregnancy (1).Objectives:To compare disease activity during pregnancy in patients with or without bDMARD exposure at conception and during pregnancy and to assess pregnancy outcomes.Methods:RHEKISS is a prospective longitudinal cohort study including patients with confirmed diagnose of inflammatory rheumatic di

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Yalniz, Fevzi F., Rima M. Saliba, Orhan K. Yucel, et al. "Somatic Mutations Improve Risk Classification By Cytogenetic Abnormalities in Patients with Myelodysplastic Syndrome after Hematopoietic Stem Cell Transplantation." Blood 134, Supplement_1 (2019): 512. http://dx.doi.org/10.1182/blood-2019-125937.

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Background: Hematopoietic stem cell transplantation (HSCT) offers potentially curative therapy for patients with myelodysplastic syndrome (MDS) but disease progression after HSCT remains a major reason for failure after transplant. Identification of risk factors for progression of MDS after HSCT would allow to identify target population for early initiation of preventive treatments to improve outcomes. Methods: Patients with a diagnosis of MDS who received first HSCT between 2013 and 2018 with available pre-transplant genetic profile obtained from next generation sequencing of genes were inclu

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Alvarez Reguera, C., A. Herrero Morant, L. Sanchez Bilbao, et al. "SAT0508 DIAGNOSIS OF BEHÇET’S DISEASE: COMPARISON OF TWO SETS OF CLASSIFICATION CRITERIA. APPLICATION IN 111 PATIENTS OF A WELL-DEFINED POPULATION." Annals of the Rheumatic Diseases 79, Suppl 1 (2020): 1210.3–1210. http://dx.doi.org/10.1136/annrheumdis-2020-eular.5166.

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Background:Behçet’s disease (BD) is a systemic, chronic, relapsing vasculitis with no pathognomonic diagnostic test. The most widely used classification criteria are those of the International Study Group (ISG) for BD (1). These criteria were repeatedly found to have low sensitivity. Therefore, the International Criteria for Behçet’s Disease (ICBD) were published in 2014 (2).Objectives:To compare the ISG with ICBD diagnostic criteria for BD.Methods:The study included all consecutive 111 patients diagnosed with definitive or possible BD by expert rheumatologists. They were diagnosed at a well-d

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Telio, David, Clement Ma, Richard Tsang, Armand Keating, Michael Crump, and John Kuruvilla. "Outcomes of Second-Line Chemotherapy and Autologous Stem Cell Transplantation for Primary Refractory Diffuse Large B Cell Lymphoma." Blood 112, no. 11 (2008): 4445. http://dx.doi.org/10.1182/blood.v112.11.4445.4445.

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Abstract Introduction: Patients (pts) with primary refractory Diffuse Large B Cell Lymphoma (REF DLBCL - defined as progession within 3 months of completion of primary therapy) sensitive to salvage chemotherapy are treated with high dose therapy and autologous stem cell transplantation (ASCT). The randomized Parma trial demonstrated survival benefit for patients with chemosensitive relapse undergoing ASCT but did not include primary refractory cases, thus current practice is based largely on retrospective series Methods: We conducted a retrospective review of 112 consecutive cases of REF DLBCL

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Borghaei, Hossein, Michael Boyer, Melissa Johnson, et al. "359 AMG 757, a half-life extended bispecific T-cell engager (BiTE®) immune therapy against DLL3 in SCLC: phase 1 interim results." Journal for ImmunoTherapy of Cancer 8, Suppl 3 (2020): A384. http://dx.doi.org/10.1136/jitc-2020-sitc2020.0359.

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BackgroundDelta-like ligand 3 (DLL3) is an inhibitory Notch ligand that is highly expressed in small cell lung cancer (SCLC) and minimally expressed in normal tissues.1 AMG 757, a half-life extended BiTE® immune therapy, binds to DLL3 on tumor cells and CD3 on T cells, resulting in T cell-dependent killing of tumor cells. We report initial safety and efficacy from the ongoing phase 1 study of AMG 757 in patients with SCLC.MethodsAMG 757 was administered intravenously every two weeks (with/without step dose) at doses of 0.003–3.0 mg. Eligible patients had SCLC that progressed or recurred follow

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Aoki, Naomi J., Kylie Venardos, Nick Andrianopoulos, et al. "Use of Blood Components in Major Obstetric Hemorrhage: Preliminary Findings from the Australian and New Zealand Massive Transfusion Registry (ANZ-MTR)." Blood 124, no. 21 (2014): 1563. http://dx.doi.org/10.1182/blood.v124.21.1563.1563.

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Abstract Introduction: Major obstetric hemorrhage (MOH) can develop rapidly and, due to the unique characteristics of maternity patients, early recognition and management can be challenging. Use of blood components in MOH can be life-saving however there is uncertainty about optimal use of these products and the role of adjunctive therapies. The ANZ-MTR generates observational data on current transfusion management and outcomes in critically bleeding patients receiving massive transfusion (MT) across all clinical settings. This study aimed to describe the transfusion strategies used in the MOH

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Sora, Federica, Simona Sica, Carmen Di Grazia, et al. "Busulfan Fludarabine (BU-FLU) Compared to Thiotepa Busulfan Fludarabine (TBF) for Allogeneic Transplants in Acute Myeloid Leukemia (AML) or Refractory Anemia with Excess Blasts (RAEB) in Remission." Blood 130, Suppl_1 (2017): 909. http://dx.doi.org/10.1182/blood.v130.suppl_1.909.909.

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Abstract INTRODUCTION The combination of Busulfan and fludarabine (BU-FLU) is considered a standard conditioning regimen for patients with acute myeloid leukemia undergoing an allogeneic hemopoietic stem cell transplant (HSCT) , especially in patient older than 40 years of age. However, in a recent prospective study, designed for patients in first or second remission (CR1 or CR2) the incidence of leukemia relapse at 3 years was 38%, both for patients receiving BU-FLU as well as for patients randomized to BU-CY (Lancet Oncol 2015;16:1525). The addition of thiotepa to a BU-FLU regimen (referred

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Sebert, Marie, Aspasia Stamatoullas, Thorsten Braun, et al. "Azacitidine (AZA) Combined with Idarubicin in Higher Risk MDS - Results of a Phase I/II Study By the Groupe Francophone Des Myelodysplasies (GFM)." Blood 126, no. 23 (2015): 2884. http://dx.doi.org/10.1182/blood.v126.23.2884.2884.

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Abstract Background: Hypomethylating agents, especially AZA, have become the reference treatment of higher risk MDS, but the median survival of about 2 years obtained with AZA remains modest, and must be further improved. In addition, AZA yields only about 30% of marrow responses (including CR+PR+marrow CR). Intensive chemotherapy combining Idarubicin (IDA) and AraC yields 30 to 50 % CR in higher risk MDS (Beran and all, cancer 2001) and IDA, as single agent, induces about 30% CR in elderly AML patients (Carella, haematologica 1990). We designed a phase I/II study evaluating the safety and eff

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MacMillan, Margaret L., Marie Robin, Andrew C. Harris, et al. "A Refined Clinical Risk Score at Onset of Treatment for Acute Gvhd That Predicts Response to Initial Therapy, Survival and Transplant-Related Mortality." Blood 124, no. 21 (2014): 188. http://dx.doi.org/10.1182/blood.v124.21.188.188.

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Abstract Corticosteroids are the standard initial therapy for acute graft-versus-host disease (aGVHD) but are effective in only half of the cases. Methods to identify patients who are unlikely to respond to conventional initial therapy and who warrant alternative, more effective initial therapy are needed. The Minnesota (MN) group recently defined high-risk (HR)-aGVHD at onset by a novel acute GVHD risk score (Br J Haem 157(6):732,2012). Patients with HR-aGVHD were less likely to respond to steroid therapy and had a 2-fold increased risk of treatment-related (non-relapse) mortality (TRM) compa

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Beksac, Meral, Simona Iacobelli, Luuk Gras, et al. "Validation of the EBMT Multiple Myeloma Early Relapse Score within Worldwide Network for Blood and Marrow Transplantation (WBMT) Global Study." Blood 144, Supplement 1 (2024): 4733. https://doi.org/10.1182/blood-2024-200071.

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Rationale: Early relapse (ER) within 12 months of Autologous Hematopoietic Stem Cell Transplantation (AHCT) is currently accepted as functional high risk among patients diagnosed with Multiple Myeloma (MM). Efforts to predict ER has led to different risk scores developed by CIBMTR, GIMEMA and EBMT. CIBMTR and GIMEMA score integrates parameters not always available (bone marrow plasma cell percentage prior to AHCT, lambda light chain, FISH and LDH), whereas the EBMT score includes very simple factors ISS (at diagnosis), performance and disease status (prior to AHCT) (Beksac et al BMT 2023). EBM

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Shaiko, A. "Study of Sporo-Lex probiotic effectiveness on pigs." Naukovij vìsnik veterinarnoï medicini, no. 1(173) (June 24, 2022): 92–100. http://dx.doi.org/10.33245/2310-4902-2022-173-1-92-100.

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Food sorbents are veterinary drugs and feed additives designed to bind toxic substances in the gastrointestinal tract and remove them from the body of animals. The goal of the work is to conduct a study of the effectiveness of the veterinary drug Sporo-Lex for use on pigs. Materials and methods. Probiotic Sporo-Lex is a mixture of probiotic cultures of Bacillus licheniformis VK-25 and Bacillus subtilis MK-3 on a natural standardized sorbent (montmorillonite rock of the Volodymyretsk city deposit). The research was carried out in the conditions of a private pig farm on 74-day-old landrace pigs,

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Nurani, Yuliani, Niken Pratiwi, Robinson Situmorang, and Ni Gusti Ayu Made Yeni Lestari. "Children’s Character Learning Model Based on Indonesian Local Wisdom: Implemented to Early Childhood Education in Play Centers." JPUD - Jurnal Pendidikan Usia Dini 18, no. 1 (2024): 99–111. http://dx.doi.org/10.21009/jpud.181.07.

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Character education can equip young children to become Indonesia's golden generation who are superior and skilled in noble work. This research aims to produce an early childhood character learning model based on local Indonesian wisdom through the Playing Center title which will be implemented at Early Childhood Education Institutions (ECE) in Indonesia. This research method uses the steps of the Borg and Gall research and development model. The subjects in this research were 30 teachers from five ECE institutions in the DKI Jakarta area. The data used as the basis for building a framework for

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Carrasco Choque, Freddy, Mario Villegas Yarleque, and Janet Del Rocio Sanchez Castro. "Análisis univariante para describir y pronosticar la producción de plátano en la región de piura." Universidad Ciencia y Tecnología 25, no. 109 (2021): 71–79. http://dx.doi.org/10.47460/uct.v25i109.450.

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La actividad agrícola en la región de Piura, es una actividad fundamental para su desarrollo, la implementación de pronósticos es una herramienta útil para los agentes económicos para una planificación y toma de decisiones acertadas. En el estudio interesan dos resultados, el primero identificar, estimar y validar un modelo ajustado para pronosticar la producción de plátano y el segundo realizar el pronóstico de la producción de plátano para el periodo de octubre de 2020 hasta octubre de 2022. Para concretizar los objetivos se realizó el análisis univariante con la metodología de Box y Jenkins

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Fitria Budi Utami. "The Implementation of Eating Healthy Program in Early Childhood." JPUD - Jurnal Pendidikan Usia Dini 14, no. 1 (2020): 125–40. http://dx.doi.org/10.21009/141.09.

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   Eating habits develop during the first years of a child's life, children learn what, when, and how much to eat through direct experience with food and by observing the eating habits of others. The aim of this study is to get a clear picture of the Eating program Healthy, starting from the planning, implementation, supervision, and evaluation as a case study of nutrition education; to get information about the advantages, disadvantages and effects of implementing a healthy eating program for children. This research was conducted through a case study with qualitative data an

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Ihsan Mulia Siregar and Slamet Haryono. "Green Banking: Operating Costs on Operating Income, Capital Adequacy Ratio, Financial Slack, Sustainability Officer, and Sustainability Committee." Jurnal Ekonomi Syariah Teori dan Terapan 10, no. 5 (2023): 427–42. http://dx.doi.org/10.20473/vol10iss20235pp427-442.

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ABSTRACT This study aims to investigate and analyze e the effect of Operating Expenses Operating Income (BOPO), capital adequacy ratio (CAR), financial slack, sustainability officer, and sustainability committee on green banking disclosure in Islamic banks registered with the Financial Services Authority (OJK) during the period 2017-2021. In this study, panel data regression data analysis techniques were used with the help of Eviews 10 software. The results of this study show that partially the variables Operating costs in operating income (BOPO), capital adequacy ratio (CAR), financial slack,

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"EPIDEMIOLOGY OF TRAUMATIC SPINAL CORD INJURY IN SALAH-ALDEEN PROVINCE- IRAQ." International Journal of Medical Science in Clinical Research and Review 05, no. 05 (2022): 652–56. https://doi.org/10.5281/zenodo.7110273.

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Original Research Paper <strong>EPIDEMIOLOGY OF TRAUMATIC SPINAL CORD INJURY IN SALAH-ALDEEN PROVINCE- IRAQ</strong> <strong>Authors:</strong> <strong><sup>1</sup></strong><strong>Dr. Harith Ahmed Azeez, <sup>2</sup>Mozheer A. Abood, <sup>3</sup>Abeer Jassim Hamdan,<sup>4</sup>Dr. Zaid Al-Attar,<sup>5</sup>Dr. Husam H. Alkhafaji <sup>6</sup>Naseem Jaafar Sadiq, <sup>7</sup>Dr. Khalaf A. A.</strong> <em><sup>1,2,7</sup></em><em>Medical Rehabilitation Hospital, Tikrit</em> <em><sup>3</sup></em><em>Shaikh Zayed Hospital</em> <em><sup>4</sup></em><em>Al-Kindy College of Medicine / University of Ba

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Hussain Mian, Abrar. "Isolation And Characterization Of Biosurfactant Producing Bacteria From Different Environmental Soil Samples." Journal of Toxicology and Environmental Sciences 1, no. 1 (2021): 36–47. http://dx.doi.org/10.55124/jtes.v1i1.133.

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Biosurfactants are natural substances produced by several bacterial and fungal organisms that are amphiphilic and are extracellular (a part of the cell membrane). Biosurfactants can reduce the stress between solids and liquids on the surface and at the end. Biosurfactants have several properties, i.e. they are stable, less harmful, as well as readily degradable, and extremely eco-friendly. Biosurfactants also have a wide range of industrial uses because they are a versatile category of chemical substances. The principal justification for conducting such research was the isolation of possible b

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Birk, Manjot, Vivien Chan, Nicholas J. Yee, et al. "Canadian Spine SocietyCPSS-1. Abstract ID 108. Radiographic reporting in adolescent idiopathic scoliosis: Is there a discrepancy between radiologists’ reports and surgeons’ assessments?CPSS-2. Abstract ID 21. Pediatric posterior spinal deformity correction: 30-day postoperative infection rate and risk factorsCPSS-3. Abstract ID 17. “Ultra-low dose” computed tomography without sedation is feasible and should be considered as part of the preoperative optimization pathway in paediatric patients with neuromuscular scoliosisCPSS-4. Abstract ID 20. SeeSpine: a novel surface topography smartphone application for monitoring curve progression in adolescent idiopathic scoliosisCPSS-5. Abstract ID 78. Pilot study: a machine learning algorithm for the detection of adolescent idiopathic scoliosis from images taken with modern smartphone technologyCPSS-6. Abstract ID 101. Preoperative parameters influencing vertebral body tethering outcomes: patient characteristics play an important role in determining the outcomes at 2 years after surgeryCPSS-7. Abstract ID 63. Preoperative bending radiographs are the best predictor of scoliosis correction on the first erect radiograph in vertebral body tethering: a single-centre retrospective studyCPSS-8. Abstract ID 18. Adverse events after zoledronate infusion in medically complex patients with neuromuscular scoliosisCPSS-9. Abstract ID 5. Sequential rod rolling for surgical correction of Lenke type 2 adolescent idiopathic scoliosis: a 3D analysisCPSS-10. Abstract ID 123. A comparative study of protocols for spinal casting as a surgical delay strategy in severe early-onset scoliosisA-11. Abstract ID 50. Does the type of pelvic fixation affect pelvic incidence after adult spinal deformity surgery? A retrospective analysisA-12. Abstract ID 51. How does pelvic fixation affect the compensatory mechanisms after adult spinal deformity surgery? A retrospective analysisA-13. Abstract ID 44. Development of a biomechanical model to identify risk factors in sagittal alignment contributing to proximal junctional kyphosisA-14. Abstract ID 32. Biomechanical characterization of semirigid constructs and the potential effect on proximal junctional kyphosisA-15. Abstract ID 65. Early adjacent disc characteristics are not associated with reoperation in short-segment lumbar fusionsA-16. Abstract ID 39. Concurrent validation of a novel inertial measurement unit–based method to evaluate spinal motion in clinical settingsA-17. Abstract ID 68. Distal lordosis is associated with reoperation for adjacent segment disease in patients with degenerative lumbar fusionA-18. Abstract ID 69. Automatic extraction of spinopelvic parameters using artificial intelligence methods and a review on the effects of spine stiffness, spinal fusion and spinopelvic parameters on lower limb motion and total hip arthroplasty outcomesA-19. Abstract ID 38. Gender differences in fusion rates in the treatment of degenerative lumbar spondylolisthesis: analysis from the CSORN prospective degenerative lumbar spondylolisthesis studyA-20. Abstract ID 29. L3–4 hyperlordosis after a reduction in lower lumbar lordosis with L4–L5 fusion surgery is common in patients requiring L3–4 revision surgery for adjacent segment diseaseB-21. Abstract ID 40. Predictors of dynamic instability in the decision to fuse in degenerative lumbar spondylolisthesis: results from the Canadian Spine Outcomes and Research Network prospective degenerative lumbar spondylolisthesisstudyB-22. Abstract ID 49. Impact of preoperative insomnia on poor postoperative pain control after elective spine surgery and the Modified Calgary Postoperative Pain After Spine Surgery scoreB-23. Abstract ID 115. Influence of high pelvic incidence on operative difficulty in patients treated surgically for degenerative lumbar spondylolisthesisB-24. Abstract ID 45. Reoperation rates for adjacent segment disease in degenerative lumbar fusion surgery: a comparison between minimally invasive versus open surgical approachesB-25. Abstract ID 118. Assessment of changes in opioid utilization 1 year after elective spine surgery: a Canadian Spine Outcomes and Research Network studyB-26. Abstract ID 93. Preoperative neuroleptic and opioid use effects on postoperative pain and disability after spinal surgery for lumbar radiculopathyB-27. Abstract ID 52. The importance of lower extremity compensation mechanisms in lumbar degenerative pathology: a retrospective analysisB-28. Abstract ID 107. Persistent poor sleep is associated with worse pain and quality of life in patients with degenerative thoracolumbar conditions undergoing surgery: a retrospective cohort studyB-29. Abstract ID 126. Opioid use in low back pain is associated with increased utilization of health care services and likelihood of work absenteeismB-30. Abstract ID 53. Wait times for degenerative lumbar spine consultation and surgery: a repeated cross-sectional analysis of the Canadian Spine Outcomes and Research NetworkC-31. Abstract ID 33. Patients with radicular pain improve more than those with axial pain alone after treatment for metastatic spine diseaseC-32. Abstract ID 46. Association between nutritional status and survival in patients requiring treatment for spinal metastasesC-33. Abstract ID 47. Introduction of the new Patient Expectations in Spinal Oncology questionnaireC-34. Abstract ID 74. Medium-term follow-up outcomes in palliative transpedicular corpectomy with cement-based anterior vertebral reconstruction performed for patients with spinal metastasisC-35. Abstract ID 10. Perception of frailty in spinal metastatic disease: international survey of the AO Spine CommunityC-36. Abstract ID 73. COVID-19: Were we able to get back to the prepandemic level of spine surgery activity? An experience from a tertiary referral centre in QuebecC-37. Abstract ID 114. Provider confidence with virtual spine exams 2 years after COVID-19 lockdown restrictionsC-38. Abstract ID 76. The impact of nasal decontamination by photodisinfection in spine surgery: a feasibility pilot studyC-39. Abstract ID 116. Exploring the bacterial hypothesis of low back pain: a prospective cohort studyC-40. Abstract ID 7. Management of deep surgical site infections of the spine: a Canadian surveyD-41. Abstract ID 26. Earlier tracheostomy reduces complications in complete cervical spinal cord injury in real-world practice: analysis of a multicentre cohort of 2001 patientsD-42. Abstract ID 87. Neuroprotection after traumatic spinal cord injury through mitochondrial calcium uniporter inhibitionD-43. Abstract ID 16. The impact of specialized versus nonspecialized acute hospital care on survival among patients with acute incomplete traumatic spinal cord injuries: a population-based observational study from British Columbia, CanadaD-44. Abstract ID 59. Stem cells from human spinal cord exhibit reduced oligodendrogenesis compared with rodent stem cellsD-45. Abstract ID 122. Harnessing the endogenous stem cell response after spinal cord injuryD-46. Abstract ID 62. Comparison of age and 5-Item Modified Frailty Index as predictors of in-hospital mortality for patients with complete traumatic cervical spinal cord injuryD-47. Abstract ID 109. Unplanned readmissions after traumatic spinal cord injury: perspective from the British Columbian populationD-48. Abstract ID 9. The radiographic characteristics that lead surgeons to agree and disagree on making treatment recommendations in thoracolumbar burst fractures without neurologic deficitsD-49. Abstract ID 19. The effect of Enhanced Recovery After Surgery protocols for elective cervical and lumbar spine procedures on hospital length of stay: a systematic review and meta-analysisD-50. Abstract ID 23. Exploring end-of-life decision-making and perspectives on medical assistance in dying through the eyes of individuals living with cervical spinal cord injuries in Nova ScotiaE-51. Abstract ID 88. Neurologically intact thoracolumbar burst fractures (AO Spine A3, A4) improve on Oswestry Disability Index equally when treated surgically versus nonoperativelyE-52. Abstract ID 28. Predictive algorithm for surgery recommendation in thoracolumbar burst fractures without neurological deficitsE-53. Abstract ID 36. A randomized trial of cervical orthosis versus no orthosis after multilevel posterior cervical fusionE-54. Abstract ID 11. Deterioration after surgery for degenerative cervical myelopathy: an observational study from the Canadian Spine Outcomes and Research NetworkE-55. Abstract ID 66. Canadian cohort of older patients with cervical spinal cord injury: Do radiologic parameters correlate with initial neurological impairment?E-56. Abstract ID 6. Surgical complications or neurologic decline? A patient discrete-choice experiment for cervical myelopathyE-57. Abstract ID 82. Laminectomy alone for cervical spondylotic myelopathy: a Canadian Spine Outcomes and Research Network StudyE-58. Abstract ID 95. The effect of surgical approach on patient outcomes of degenerative cervical myelopathy: a pooled analysis of individual patient data from 1031 casesE-59. Abstract ID 81. Occiput and upper cervical fusions: Does navigation matter? A Canadian Spine Outcomes and Research Network studyE-60. Abstract ID 89. Preoperative therapies improve postoperative disability in patients who undergo anterior cervical discectomy and fusion surgery for cervical radiculopathyF-61. Abstract ID 58. The influence of wait time on surgical outcomes in elective lumbar degenerative surgery: a Canadian Spine Outcomes and Research Network studyF-62. Abstract ID 77. A cost consequence analysis comparing spinal fusion versus decompression alone for lumbar degenerative spondylolisthesisF-63. Abstract ID 96. Economic impact of wait time in degenerative lumbar stenosis surgery: association with time away from work, chronic persistent opioid use and patient satisfactionF-64. Abstract ID 121. Optimal timing of surgery for symptomatic single-level lumbar disc herniation: a cost-effectiveness analysisF-65. Abstract ID 67. Impact of scheduled spine surgery for degenerative spinal disorders on patient health-related quality of life compared with the general Canadian populationF-66. Abstract ID 84. Decompression and decompression and fusion and the influence of spinopelvic alignment in the outcome of patients with degenerative lumbar spondylolisthesisF-67. Abstract ID 43. Association between poor postoperative pain control and surgical outcomes after elective spine surgeryF-68. Abstract ID 56. Factors associated with shorter wait times for lumbar degenerative spinal surgeryF-69. Abstract ID 25. Is navigation a game changer in single-level transforaminal lumbar interbody fusions?F-70. Abstract ID 34. Radiologic and clinical evaluation of posterolateral versus interbody fusion in degenerative lumbar spondylolisthesisG-71. Abstract ID 15. Timing of recovery after surgery for patients with degenerative cervical myelopathy: an observational study from the Canadian Spine Outcomes and Research NetworkG-72. Abstract ID 30. Development of a patient-centred cervical myelopathy severity index: measurement property testing, item generation and item reductionG-73. Abstract ID 75. The preoperative expectations of patients with degenerative cervical myelopathyG-74. Abstract ID 61. Satisfaction with surgical treatment for degenerative cervical myelopathy is driven by improvement in patient-reported outcomesG-75. Abstract ID 98. Identification of surgical candidates for mild degenerative cervical myelopathy: a trajectory-based analysisG-76. Abstract ID 100. The impact of surgery on pain in degenerative cervical myelopathy: a pooled analysis of 1047 patients from CSM-North America, CSM-International and CSM-Protect trialsG-77. Abstract ID 104. National adverse event rates after cervical spine surgery for degenerative disorders, and impact on patient satisfactionG-78. Abstract ID 8. The unsustainable growth of out-of-hours emergent surgery for degenerative spinal disease in Canada: a retrospective cohort study from a national registryG-79. Abstract ID 102. Effect of compensation claim status on perioperative outcomes in patients with degenerative spine conditionsG-80. Abstract ID 13. Outcomes of spinal cord stimulation for management of neuropathic pain in patients with spinal cord injuryP-81. Abstract ID 97. Meaningfulness in clinical improvements at 12 months after surgery for degenerative cervical myelopathy: comparison of 30% change versus absolute change values of minimal clinically important differenceP-82. Abstract ID 22. An exploration of the evolving perception of quality of life from the perspective of individuals living with a cervical spinal cord injury in Nova ScotiaP-83. Abstract ID 41. Delays in diagnosis of degenerative cervical myelopathy: a population-based study using the Clinical Practice Research DatalinkP-84. Abstract ID 119. Sex, drugs and spine surgery: a nationwide analysis of opioid utilization and patient-reported outcomes in males and femalesP-85. Abstract ID 117. The feasibility of a multidisciplinary transitional pain service in patients undergoing spine surgery to minimize opioid use and improve perioperative outcomes: a quality improvement studyP-86. Abstract ID 103. Predictors of poor postoperative patient satisfaction in patients undergoing elective spine surgery with pre-existing compensation claimsP-87. Abstract ID 60. The efficacy and safety of P-15 peptide enhanced bone graft in bone regeneration: a systematic reviewP-88. Abstract ID 113. The influence of preoperative back pain on patient-rated outcomes after decompression with or without fusion for degenerative lumbar spondylolisthesis: results from the Canadian Spine Outcomes and Research Network prospective degenerative lumbar spondylolisthesis studyP-89. Abstract ID 55. Publication retraction in spine surgery: a systematic reviewP-90. Abstract ID 12. The use of a standardized surgical case log to document operative exposure to procedural competencies in a spine surgery fellowship curriculum: a university-wide initiativeP-91. Abstract ID 90. Preoperative psychosocial factors affect the outcomes experienced by patients who undergo anterior cervical discectomy and fusion surgery for cervical radiculopathyP-92. Abstract ID 91. Virtual reality for patient-specific, multidisciplinary planning of complex orthopedic oncological surgery including the spineP-93. Abstract ID 35. Malposition in robotic-assisted cortical bone trajectory screw placement: analysis of 1025 consecutive screwsP-94. Abstract ID 79. Accuracy of computer-assisted spine navigation platforms: a meta-analysis of 16 040 screwsP-95. Abstract ID 86. Which is better: percutaneous or open robot-assisted spine surgery? Prospective, multicentre study of 2524 screws in 336 patientsP-96. Abstract ID 124. Opioid use in low back pain is associated with decreased quality of life, increased disability and worse treatment outcomes: a stratified propensity score analysisP-97. Abstract ID 85. Incidence and management of deep spine surgical-site infections: a systematic review and meta-analysisP-99. Abstract ID 110. Associations of preoperative analgesic use with postoperative pain and disability after spinal surgery for cervical myelopathy and radiculopathyP-100. Abstract ID 42. Cervical myelopathy and social media: a mixed-methods analysisP-101. Abstract ID 24. The use of machine learning to predict the presence of cauda equina syndrome among patients with disc herniationP-102. Abstract ID 112. A systematic review of the content and structure of composite end points in spine surgery interventional trialsP-103. Abstract ID 106. Surveying the knowledge and attitudes of moving to a high-quality, low-carbon health care systemP-104. Abstract ID 125. Variability in treatment of adult spinal deformity, a Canadian surveyP-105. Abstract ID 83. Anterior cervical hybrid constructs reduce upper adjacent segment hypermobility compared with anterior cervical discectomy and fusionP-106. Abstract ID 48. A preliminary report of robotic screw insertion in cadaveric vertebrae using the Mazor X systemP-107. Abstract ID 54. Invasive brain–computer interface for motor restoration in spinal cord injury: a systematic reviewP-108. Abstract ID 27. A new cost-effective technique to mimic pedicle screw trajectory in cadavers: a robotic validation studyP-109. Abstract ID 14. Developments and applications of augmented and virtual reality technology in spine surgery training: a systematic reviewP-110. Abstract ID 80. Comprehensive accuracy analysis of robotic models in spine surgery: a pooled analysis of 14 462 screwsP-111. Abstract ID 99. Familial chiari malformation: a systematic reviewP-112. Abstract ID 31. Ninety-day complication and revision surgery rates using navigated robotics in thoracolumbar spine surgeryP-113. Abstract ID 111. Which baseline clinical factors and clinical indications are most correlated with outcome after lumbar fusion surgery?P-114. Abstract ID 92. Characterization of the mechanical state of human mesenchymal stem cells on micro- or nano-textured Ti6Al4V surfacesP-115. Abstract ID 72. Short-term outcomes associated with the use of macro–micro–nano rough Ti6Al4V (nanoLOCK) interbody cages in patients with lumbar spine degenerative conditionsP-116. Abstract ID 127. Introduction of a novel concept to decompress foramen magnum in chiari-1 malformation without affecting stabilityP-117. Abstract ID 57. Minimally invasive tubular lumbar decompression without fusion in lumbar stenosis with underlying deformity: Friend or foe?P-118. Abstract ID 64. The role of intraoperative ultrasound in nononcological intradural lumbar spine conditions: intradural lumbar disc herniation and subdural spinal abscessP-119. Abstract ID 120. Prospective Prophylactic Antibiotics Regimen in Spine Surgery: the PPARiSS cohortP-121. Abstract ID 70. Decompression versus decompression and fusion in cauda equina syndrome secondary to massive lumbar disc herniationP-122. Abstract ID 105. Implementation of robot-assisted surgery for elective spine surgeryP-123. Abstract ID 37. Spine surgery in patients with morbid obesity: tips and tricksP98: Abstract ID 71. Pelvic incidence is associated with reoperation for adjacent segment disease in degenerative lumbar spinal fusion surgery." Canadian Journal of Surgery 66, no. 4 Suppl 1 (2023): S1—S53. http://dx.doi.org/10.1503/cjs.006523.

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Van Montfoort, A., M. De Rycke, F. Carvalho, et al. "O-041 Data from the ESHRE PGT consortium – year 2020." Human Reproduction 37, Supplement_1 (2022). http://dx.doi.org/10.1093/humrep/deac104.047.

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Abstract Study question Which are the trends shown in data collection XXII of the European Society of Human Reproduction and Embryology (ESHRE) PGT Consortium compared with previous years? Summary answer Data collection XXII, year 2020, represents valuable data on PGT activity in (mainly) Europe and reports on the main trends observed, being the further expansion of comprehensive testing technology in PGT-SR and PGT-A. What is known already The ESHRE PGT Consortium was set up in 1997 and from that time has been collecting data on PGT and PGT-A. The PGT database comprises the world’s largest co

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Adinolfi, A., S. Sirotti, G. Sakellariou, et al. "POS1141 ASSESSING RELEVANT JOINTS FOR MONITORING CPPD DISEASE: A SYSTEMATIC LITERATURE REVIEW OF IMAGING TECHNIQUES BY THE OMERACT ULTRASOUND – CPPD SUBGROUP." May 25, 2021. https://doi.org/10.1136/annrheumdis-2021-eular.3153.

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Background:Imaging has been extensively used for the Calcium Pyrophosphate Deposition Disease (CPPD) diagnosis but the prevalence of joint calcifications at imaging in CPPD patients has not been thoroughly assessed.Objectives:This systematic literature review (SLR) is aimed to estimate the prevalence of calcium crystal deposition in peripheral joints by imaging in suspected or definite CPPD patients to establish relevant joints for CPPD monitoringMethods:After defining PICOs, Pubmed and Embase were searched from inception to October 2020 for identifying studies that evaluated the use of Conven

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Chowdhury, Aruba, Faith Davis, Andrea Krenek, Sydney Dixon, Lilian Mabundo, and Stephanie T. Chung. "Abstract 13940: Remnant Lipoprotein Particles and Cholesterol Contribute to Proatherogenic Phenotype and Subclinical Inflammation in Youth-Onset Type 2 Diabetes." Circulation 148, Suppl_1 (2023). http://dx.doi.org/10.1161/circ.148.suppl_1.13940.

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Introduction: Youth-onset type 2 diabetes (YT2D) is a rapidly progressive disease characterized by severe insulin resistance (IR), elevated triglyceride concentrations, and low HDL-cholesterol (-C). However, the contribution of triglyceride-rich remnant lipoproteins (TRLp) and remnant-C to overall atherogenic risk in YT2D is unknown, especially in the absence of clinically relevant elevations in LDL-C. Hypothesis: We hypothesized that YT2D would have higher remnant TRLp, remnant-C, and greater subclinical inflammation and IR compared to healthy peers with obesity. Methods: We measured fasting

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Khoury, Ruby, Michael Jordan, Jack Bleesing, et al. "Addition of Thiotepa to Alemtuzumab, Fludarabine, and Melphalan Reduced-Intensity Conditioning Reduces Secondary Graft Failure in Allogeneic HSCT for Inborn Errors of Immunity." Journal of Human Immunity 1, CIS2025 (2025). https://doi.org/10.70962/cis2025abstract.61.

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Introduction Alemtuzumab, fludarabine, and melphalan reduced-intensity conditioning (RIC) regimen is associated with a high incidence of mixed chimerism and secondary graft failure in patients undergoing allogeneic hematopoietic stem cell transplant (HSCT) for inborn errors of immunity (IEI). We hypothesized that addition of thiotepa to this regimen would reduce secondary graft failure without increasing toxicity in children and young adults undergoing allogenic HSCT for IEI. Methods We retrospectively reviewed charts of patients undergoing allogenic HSCT for IEI who received alemtuzumab (star

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Leeper, Heather E., Elizabeth Vera, Alexa Christ, et al. "Association of Employment Status With Symptom Burden and Health-Related Quality of Life in People Living With Primary CNS Tumors." Neurology, February 8, 2023, 10.1212/WNL.0000000000207082. http://dx.doi.org/10.1212/wnl.0000000000207082.

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Background and Objectives:Financial toxicity significantly impacts many patients, especially cancer survivors. We evaluated the association of unemployment as a major contributor to financial toxicity with patient-reported outcomes (PROs) assessing multiple illness experience domains in a primary CNS tumor (PCNST) cohort.Methods:Patient and disease characteristics and PROs measuring symptom burden, interference, psychologic distress, functional impairment, and health-related quality of life (HRQOL) from participants enrolled an IRB-approved observational study at the US National Institutes of

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Taal, Maarten W., Bethany Lucas, Natasha Mcintyre, Christopher Mcintyre, and Richard Fluck. "#1321 Long term outcomes in people with fluctuating criteria for the diagnosis of chronic kidney disease." Nephrology Dialysis Transplantation 39, Supplement_1 (2024). http://dx.doi.org/10.1093/ndt/gfae069.627.

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Abstract Background and Aims The diagnostic criteria for chronic kidney disease (CKD) recognise that measures of kidney function may fluctuate in the short term by requiring that abnormalities must persist for at least 90 days to support the diagnosis. Nevertheless, studies have reported that even people who meet the diagnostic criteria may have transient or prolonged improvement in kidney function in the absence of specific treatment. In this study we used the opportunity afforded by long term follow-up of a cohort recruited from primary care to assess the impact on outcomes of fluctuations i

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Stensvold, Inger, Marit Rognerud, and Dag S. Thelle. "Dødelighet av alle årsaker i regioner og bydeler i Oslo: Sammenlikning med utvalgte europeiske land." Norsk Epidemiologi 8, no. 1 (2009). http://dx.doi.org/10.5324/nje.v8i1.423.

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<strong><span style="font-family: TimesNewRomanPS-BoldMT;"><span style="font-family: TimesNewRomanPS-BoldMT;"><p align="left"> </p></span></span><span style="font-size: x-small; font-family: TimesNewRomanPS-BoldMT;"><span style="font-size: x-small; font-family: TimesNewRomanPS-BoldMT;">SAMMENDRAG</span></span></strong><span style="font-size: x-small; font-family: TimesNewRomanPSMT;"><span style="font-size: x-small; font-family: TimesNewRomanPSMT;"><p align="left">Oslohelsa viste at det var store forskjell

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Belchinskaya, Larisa I., Konstantin V. Zhuzhukin, Konstantin A. Barkov, Sergey A. Ivkov, Vladimir A. Terekhov та Evelina P. Domashevskaya. "Влияние слабого импульсного электромагнитного поля на атомное строение природных алюмосиликатов клиноптилолита, монтмориллонита и палыгорскита". Kondensirovannye sredy i mezhfaznye granitsy = Condensed Matter and Interphases 22, № 1 (2020). http://dx.doi.org/10.17308/kcmf.2020.22/2525.

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Естественные и искусственные алюмосиликаты являются актуальными объектами исследования благодаря широкому использованию в медицине, пищевой и химической промышленностях, в сельском хозяйстве. Целью работы является исследование возможных изменений под воздействием слабого импульсного электромагнитного поля атомного строения порошкообразных образцов трех минералов: клиноптилолита NaKNa2Ca2(SiSi29Al7)О72·24H2O монтмориллонита, монтмориллонита Ca0.2( AlMg)2Si4O10(OH))2·4H2O и палыгорскита AlSiMgAlSi4O10(OH)4·H2O относящихся к группе природных алюмосиликатов,, относящихся к группе природных алюмоси

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sprotocols. "Preparation of materials for flexizyme reactions and genetic code reprogramming." January 24, 2015. https://doi.org/10.5281/zenodo.14305.

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Authors: Yuki Goto, Takayuki Katoh & Hiroaki Suga ### Abstract Genetic code reprogramming is a method for the reassignment of arbitrary codons from proteinogenic amino acids to non-proteinogenic ones, and thus specific sequences of non-standard peptides can be ribosomally expressed according to their mRNA templates. We have developed a protocol that facilitates the genetic code reprogramming using flexizymes integrated with a custom-made in-vitro translation apparatus, referred to as the flexible in-vitro translation (FIT) system. Flexizymes are flexible tRNA acylation ribozymes that enabl

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Hong Son, Bui, Vu Van Nga, Le Thi Diem Hong, and Do Thi Quynh. "Potent Natural Inhibitors of Alpha-Glucosidase and the Application of Aspergillus spp. in Diabetes type 2 Drugs: a Review." VNU Journal of Science: Medical and Pharmaceutical Sciences 38, no. 1 (2022). http://dx.doi.org/10.25073/2588-1132/vnumps.4334.

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Diabetes Mellitus has been becoming a disease of the century, and disease incidence is still rising worldwide. It causes many serious complications, especially in the eye, heart, kidneys, brain, and vascular system, such as diabetic nephropathy, diabetic retinopathy, liver failure, etc. Moreover, the process of controlling this disease is complicated. Meanwhile, the antidiabetic drugs on the market are facing some problems with a wide range of adverse reactions. Therefore, finding new drugs to treat diabetes has always been a topic that many researchers are interested in, especially drugs der

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Ratnaboli, Bose Shikha Arora Vivek Dhar Dwivedi &. Amit Pandey. "Amino acid sequence based in silico analysis of βgalactosidases". 28 червня 2013. https://doi.org/10.5121/ijbb.2013.3204.

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International Journal on Bioinformatics & Biosciences (IJBB) Vol.3, No.2, June 2013 DOI: 10.5121/ijbb.2013.3204 37 Amino acid sequence based in silico analysis of βgalactosidases Ratnaboli Bose, Shikha Arora, Vivek Dhar Dwivedi & Amit Pandey Forest Pathology Division, Forest Research Institute, Dehradun, India vivek_bioinformatics@yahoo.com Abstract Amino acid sequences of β-galactosidase enzyme belonging to different families of bacteria, fungi and plants retrieved from GenPept database were analyzed for multiple sequence alignment, cluster analysis, conserved motif discover

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Dana O. Kareem, Ahmed MS. Amin, Ayman M. Mustafa, et al. "Tracing Hematological Shifts in Pregnancy: How Anemia and Thrombocytopenia Evolve Across Trimesters." Barw Medical Journal 3, no. 2 (2025). https://doi.org/10.58742/bmj.v3i2.171.

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Abstract Introduction Given pregnancy's significant impact on hematological parameters, monitoring these changes across trimesters is crucial. This study aims to evaluate hematological profiles in pregnant women, primarily focusing on the prevalence of anemia and thrombocytopenia throughout the different trimesters. Methods This retrospective cross-sectional study was conducted at Smart Health Tower from March to December 2024, with ethical approval from Kscien Organization. Pregnant women aged 18-45 years in any trimester were included, excluding those with pre-existing hematological disorder

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