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Journal articles on the topic '336.7:794 (043.2)'

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Published: 30 May 2022

Last updated: 31 July 2025

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1

Pranab, Ghosh, Debnath Utpal, and Prasad Pradhan Bhim. "Bromination of cholest-4-en-3,6-dione with N-bromosuccinimide in chloroform." Journal of Indian Chemical Society Vol. 90, Apr 2013 (2013): 533–37. https://doi.org/10.5281/zenodo.5771284.

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Natural Product and Polymer Chemistry Laboratory, Department of Chemistry, University of North Bengal, Darjeeling-734 013, West Bengal, India <em>E-mail</em> : pizy12@yahoo.com <em>Manuscript received 15 December 2011, revised 20 March 2012, accepted 07 June 2012</em> The reaction of cholest-4-en-3,6-dione (1) with <em>N</em>-bromosuccinimide in chloroform furnishes four compounds which have been identified as 2,7α.-dibromo-cholest-1,4-dien-3,6-dione (2), 2,2,7α.-tribromo-cholest-4-en-3,6-dione (3), 2α., 7α.-dibromo-cholest-4-en-3,6-dione (4) and 2,2-dibromo-7-hydroxyl

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2

Semenova, Lioubov I., and Allan H. White. "Structural Systematics of Rare Earth Complexes. XIX (Hydrated) 1 : 2 Mononuclear Adducts of Lanthanoid(III) Chlorides with 2,2′-Bipyridine and 1,10-Phenanthroline." Australian Journal of Chemistry 52, no. 6 (1999): 571. http://dx.doi.org/10.1071/ch98052.

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Room-temperature single-crystal X-ray structure determinations are recorded for a number of adducts of hydrated lanthanoid(III) trichlorides with 2,2′-bipyridine (‘bpy’) and 1,10-phenanthroline (‘phen’), crystallized from water, methanol or ethanol solutions, containing mononuclear arrays with 1 : 2 Ln/bpy or phen stoichiometry. LaCl3/phen/H2O(1 : 3 : 9), [(phen)2La(OH2)5]Cl3.phen.4H2O, although of overall 1 : 3 LaCl3/phen stoichiometry, has a lattice phen; it is orthorhombic, Pnna, a 19·947(7), b 16·457(5), c 12·213(2) Å, Z = 4; conventional R on |F| was 0·030 for No 2567 ‘observed’ (I >3σ

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3

Pranab, Ghosh, Debnath Utpal, and P. Pradhan B. "Dehydrobromination and debromination of 2,2, 7a-tribromocholest-4-en-3,6-dione." Journal of Indian Chemical Society Vol. 89, Jun 2012 (2012): 837–39. https://doi.org/10.5281/zenodo.5763881.

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Natural Product and Polymer Chemistry Laboratory, Department of Chemistry, University of North Bengal, Darjeeling-734 013, West Bengal, India <em>E-mail</em> : pizy12@yahoo.com Fax : 91-353-2699001 <em>Manuscript received 21 February 201J, revised 31 May 2011, accepted 17 October 2011</em> The reaction of 2,2, 7α-tribromocholest-4-en-3,6-dione (1) with lithium bromide in <em>N,N</em>-dimethyl formamide furnished a single compound identified as 2-bromocholest-1,4-dien-3,6-dione (2) by spectroscopic methods (UV, FT-IR, NMR and Mass).

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4

Demetri, George D., Jason J. Luke, Antoine Hollebecque, et al. "First-in-human phase 1 study of ABBV-085, an antibody-drug conjugate (ADC) targeting LRRC15, in sarcomas and other advanced solid tumors." Journal of Clinical Oncology 37, no. 15_suppl (2019): 3004. http://dx.doi.org/10.1200/jco.2019.37.15_suppl.3004.

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3004 Background: ABBV-085 is an ADC (conjugated to monomethyl auristatin E, drug:antibody ratio of 2:1) directed against leucine-rich repeat containing 15 (LRRC15), a type 1 transmembrane protein highly expressed on the surface of sarcomas and cancer-associated fibroblasts in stroma of many other cancers. ABBV-085 induced antitumor activity in both in vitro and xenograft models of sarcoma. This phase 1, first-in-human, 2-part study assessed the safety/tolerability of ABBV-085 in patients (pts) with advanced solid tumors (NCT02565758). Methods: Eligible pts (≥18 yr; advanced solid tumors) recei

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Bilen, Ozlem, Maha AAA Abd Elbasset, Jacquelyn Michele LaGrone, Imelda Tija, Lisa Bomgaars, and Jun Teruya. "Prothrombotic Markers As Predictors of Thrombosis in Newly Diagnosed Cancer Patients." Blood 118, no. 21 (2011): 2298. http://dx.doi.org/10.1182/blood.v118.21.2298.2298.

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Abstract Abstract 2298 The prevalence of prothrombotic markers and their association with thrombosis in pediatric solid tumor patients is not well defined. This study was aimed to discern the value of the following laboratory measures in assessment of thrombotic risk in pediatric patients with solid tumor: Prothrombin and activated partial thromboplastin times (PT and aPTT), D-dimer level, fibrinogen level, inherited and acquired hypercoagulability risk factors and soluble pro-inflammatory cytokines. Forty pediatric patients with newly-diagnosed malignancy and same number of age and sex-matche

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Roh, Kyoung Ho, Yu Kyung Kim, Shin-Woo Kim, et al. "Coinfections with Respiratory Pathogens among COVID-19 Patients in Korea." Canadian Journal of Infectious Diseases and Medical Microbiology 2021 (May 12, 2021): 1–9. http://dx.doi.org/10.1155/2021/6651045.

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The detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in upper and lower respiratory specimens and coinfection with other respiratory pathogens in patients with coronavirus disease 2019 (COVID-19) was investigated. Study subjects (N = 342) were retrospectively enrolled after being confirmed as SARS-CoV-2 positive, and their nasopharyngeal swab (NPS), oropharyngeal swab (OPS), and sputum specimens were restored for SARS-CoV-2 retesting and respiratory pathogen detection. The majority of the subjects (96.5%, N = 330) were confirmed as SARS-CoV-2 positive using NPS/OPS spe

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Gomes, Tiago Halyson de Oliveira, Welleson Feitosa Gazel, Emanuela Ferreira Goulart, Jennifer Lee Gonçalves, Gabriel Vargas Maia Chaves, and Lígia Luana Freire da Silva. "ÓBITOS DEVIDOS À SEPSE ESTREPTOCÓCICA NO BRASIL: ANÁLISE DE 13 ANOS." Revista ft 29, no. 143 (2025): 45–46. https://doi.org/10.69849/revistaft/ch10202502210945.

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Introdução: A sepse é uma síndrome caracterizada por uma resposta inflamatória exacerbada a uma infecção, levando à disfunção orgânica e risco elevado de morte. Fatores de risco como o uso de cateteres, sonda uretral, imunossupressão, comorbidades, infecções pré-existentes, resistência antimicrobiana e estado nutricional comprometido são determinantes importantes para o desenvolvimento da doença. Objetivos: O objetivo do presente trabalho é realizar o levantamento epidemiológico acerca dos óbitos por casos de septicemia estreptocócica no Brasil, em um período de 13 anos. Bem como realizar o le

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Cannon, Joseph G. "Comprehensive Organic Functional Group Transformations Edited by A. R. Katritzky, O. Meth-Cohn, and C. W. Rees. Pergamon Press (Elsevier Science Ltd.), Tarrytown, NY. 1995. 7 vols., 19.5 × 28 cm. vol. 1, xix + 1420 pp; vol. 2, xix + 1441 pp; vol. 3, xix + 941 pp; vol. 4, xix + 1352 pp; vol. 5, xix + 1442 pp; vol. 6, xix + 933 pp; vol. 7, xvii + 1251 pp. ISBN 0-08-042-322-1; 0-08-042-323-X; 0-08-042-324-8; 0-08-0442-325-6; 0-08-042-326-4; 0-08-042-704-9; 0-08-042-705-7. $4310 (set)." Journal of Medicinal Chemistry 40, no. 12 (1997): 1940. http://dx.doi.org/10.1021/jm970186l.

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9

Molina Collada, J., F. Sánchez-Alonso, C. Bohórquez, et al. "OP0138 RISK OF CANCER AFTER BIOLOGIC AND TARGETED SYNTHETIC DMARDS INITIATION IN PATIENTS WITH RHEUMATIC DISEASES AND A HISTORY OF PRIOR MALIGNANCY: DATA FROM THE BIOBADASER REGISTRY." Annals of the Rheumatic Diseases 81, Suppl 1 (2022): 88.2–89. http://dx.doi.org/10.1136/annrheumdis-2022-eular.5030.

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BackgroundPatients with a history of cancer are routinely excluded from randomized controlled trials. As consequence, data on the safety of biologic disease modifying antirheumatic drugs (bDMARDS) and targeted synthetic (ts) DMARDs are limited. Although real world data from various national registries have not provided evidence of increased cancer recurrence, additional data from real-world registries may help to confirm safety of non-TNFi bDMARDs and tsDMARDs regarding cancer recurrence to guide treatment decisions.ObjectivesTo compare the risk of incident malignancy with exposure to differen

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Kwon, Taesung, Stacy Kenyon, Kimberly Kilheeney, Stanley Martin, and Mark Shelly. "Prevalence of SARS-CoV-2 Antibody in Healthcare Workers in Central Pennsylvania." Antimicrobial Stewardship & Healthcare Epidemiology 1, S1 (2021): s49. http://dx.doi.org/10.1017/ash.2021.93.

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Background: Determining the incidence of SARS-CoV-2 in healthcare workers (HCW) is important in assessing the safety of the work environment. Though of limited use in acute illness, serologic testing can detect some infections that occur undetected. We compared the prevalence of antibodies to SARS-CoV-2 to a place of work, exposure by role and department, and use of various prevention methods. Methods: Healthcare workers (HCWs) working in Geisinger Health System were offered voluntary serology through Employee Health. Before they had blood taken, they completed a brief questionnaire. Testing w

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Scordo, Michael, Gunjan L. Shah, Satyajit Kosuri, et al. "A Comprehensive Analysis of Late Toxicities and Associated Risk Factors in Long-Term Survivors of Myeloablative Conditioned Allogeneic Hematopoietic Cell Transplantation Using Ex-Vivo CD34+ Selection-Based Graft-Versus-Host Disease Prophylaxis." Blood 128, no. 22 (2016): 4621. http://dx.doi.org/10.1182/blood.v128.22.4621.4621.

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Abstract Introduction : Myeloablative conditioned (MAC) allogeneic hematopoietic cell transplantation (alloHCT) with ex-vivo CD34+ selection results in favorable disease control and lower incidence of graft-versus-host disease (GVHD) without the need for pharmacologic immunosuppression. However, detailed analyses of post-HCT toxicities with this platform are limited. We compiled all high-grade toxicities in long-term survivors of ex-vivo CD34+ selected alloHCT with the goal of identifying areas of potential toxicity mitigation by improved patient (pt) selection and post-HCT management. Methods

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Shishkin, V., G. V. Kudriavtseva, Y. Malenkov, and V. V. Shishkin. "THU0238 ASSOCIATION OF SYSTEMIC DISEASES OF CONNECTIVE TISSUE (SDCT) AND GERONTOLOGICAL PROCESSES." Annals of the Rheumatic Diseases 79, Suppl 1 (2020): 346.1–346. http://dx.doi.org/10.1136/annrheumdis-2020-eular.1154.

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Background:The approach from the point of view of the evolutionary perspective of finding targets for therapeutic effects among the components of the cellular destruction system is critical both in the treatment of rheumatological diseases and in gerontology.Objectives:To identify the relationships between the pathways of cell death in synovial fluid (SF) of people of different age groups with SDCT.Methods:SF was analyzed in patients of two age groups. Group N 1 of patients: 10 SLE (43±2.3 years), 13 RA (45±1.6 years), 7 SSD (35±1.8 years) and 8 donors (42±2.7 years, postmortem). Group N 2 (ag

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Zarzour, Ahmad, Aziz Nazha, Matt Kalaycio, et al. "Outcome of Newly Diagnosed Acute Myeloid Leukemia (AML) Refractory to 1 or 2 Cycles of Induction Chemotherapy." Blood 126, no. 23 (2015): 1319. http://dx.doi.org/10.1182/blood.v126.23.1319.1319.

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Abstract Background Achieving a complete remission (CR) in patients with newly diagnosed acute myeloid leukemia (AML) after induction chemotherapy with cytarabine and an anthracycline (7+3) remains an important treatment goal associated with better overall survival (OS). Approximately 25-30% of younger, and up to 50% of older patients (pts) fail to achieve CR. AML pts with residual leukemia at day 14 receive a second cycle of the same regimen; whether these pts have worse survival than pts not requiring re-induction is unclear. Information on pts with primary refractory AML and the best treatm

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Taskina, E., E. Strebkova, L. Alekseeva, et al. "POS0130 ASSOCIATION BETWEEN HYPERTENSION AND OSTEOARTHRITIS." Annals of the Rheumatic Diseases 80, Suppl 1 (2021): 276.2–277. http://dx.doi.org/10.1136/annrheumdis-2021-eular.3859.

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Background:Objectives:To evaluate the relationship between arterial hypertension (AH) and the course of knee osteoarthritis (OA).Methods:The prospective study included 109 women aged 38-75 y.o., of I-III Kellgren J. - Lawrence J. stage of knee OA (ACR), who signed an informed consent. The average age was 59.3 ± 8.7 y.o. (from 38 to 74), the average duration of the OA was 7 (4-12) years. The average values of the body mass index (BMI) corresponded to obesity (30.9 ± 5.4 kg / m2), waist circumference (WC) – 94.4 ± 11.7 cm. An individual card was filled in for each patient, including anthropometr

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Visentin, Andrea, Carmela Gurrieri, Silvia Imbergamo, et al. "Epidemiology and Risk Factors of Invasive Fungal Infections Among 795 Patients with Chronic Lymphocytic Leukemia from the Padua University." Blood 128, no. 22 (2016): 2527. http://dx.doi.org/10.1182/blood.v128.22.2527.2527.

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Abstract Background Invasive fungal infections (IFI) are serious and life-threatening complications of hematological malignancies particularly in patients affected by acute myeloid leukemia and following hematopoietic stem cell transplantation. However, only few epidemiological data concerning fungal infections in chroniclymphoproliferativedisorders are available. In this work we aimed to identify the clinical and biological features of patients with chronic lymphocytic leukemia (CLL) affected by IFI. Methods We performed a single-center retrospective study based on the CLL patients referred t

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Ben Ahmed, Tarek, Maryam Karimi, Pamela Abdayem, et al. "One-year impact of a large-scale pilot multimodal personalized early cancer detection and prevention program for individuals at high risk of cancers." Journal of Clinical Oncology 43, no. 16_suppl (2025): 10543. https://doi.org/10.1200/jco.2025.43.16_suppl.10543.

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10543 Background: The Interception program (IP) is a unique initiative aiming to assess the value of a dedicated personalized care pathway for individuals at high risk (HR) of different cancers. IP includes identification of HR individuals in primary care, a One-Day-Clinic (ODC) (including individual care and workshops aimed at information, education, awareness; informed prevention decisions on an evidence-based shared personalized early detection and prevention plan), implementing and monitoring this plan with community professionals and MyInterception digital follow-up. Methods: This prospec

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Sasaki, Koji, Elias Jabbour, Hagop M. Kantarjian, et al. "Outcome of Patients (pts) with Therapy-Related De Novo Acute Myeloid Leukemia (t-de novo AML): Single Institution Experience." Blood 124, no. 21 (2014): 2273. http://dx.doi.org/10.1182/blood.v124.21.2273.2273.

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Abstract Background: Therapy-related myeloid neoplasms develop after cytotoxic chemotherapy or radiation therapy. The available data on the outcome of pts with t-de novo AML without antecedent history of myelodysplastic syndrome (MDS) is limited. Methods: We reviewed the records of pts with newly diagnosed AML who presented to our tertiary care center from 1/2000 to 1/2014. t-de novo AML was defined as having at least 20% blasts in bone marrow with a history of any previous cytotoxic chemotherapy or radiation therapy, and without an antecedent history of MDS. Leukemia-free survival (LFS) was d

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Cacciola, E., A. Cipolla, E. Di Francesco, R. Giustolisi, and R. R. Cacciola. "Treatment of Essential Thrombocythemia with Anagrelide: A Novel Antiangiogenic Agent?." Blood 104, no. 11 (2004): 4742. http://dx.doi.org/10.1182/blood.v104.11.4742.4742.

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Abstract Essential thrombocythemia is a myeloproliferative disorder complicated by thrombotic phenomena as a result of the platelet-clotting hyperactivation linked to increased angiogenesis. It is reported that vascular endothelial growth factor (VEGF) generates thrombin and promotes platelet activation and that activated megakaryocytes and platelets release VEGF. Anagrelide (ANA) is a newer cytoreductive agent which decreases megakaryocyte mass and inhibits the platelet activation. Therefore, we studied platelet factor 4 (PF4), as indicator of platelet activation, VEGF and prothrombin fragmen

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Khanna, D., E. Volkmann, K. Highland, et al. "AB0657 Severity and impact of gastrointestinal symptoms in patients with SSc-ILD treated with nintedanib: data from SENSCIS-ON." Annals of the Rheumatic Diseases 81, Suppl 1 (2022): 1456. http://dx.doi.org/10.1136/annrheumdis-2022-eular.714.

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BackgroundGastrointestinal (GI) involvement is a common manifestation of systemic sclerosis (SSc) and a frequent side-effect of drugs used to treat SSc. In the SENSCIS trial, nintedanib reduced the rate of decline in forced vital capacity (FVC) in patients with SSc-associated interstitial lung disease (SSc-ILD), with an adverse event profile characterised predominantly by GI events.ObjectivesTo assess the severity and impact of GI symptoms on quality of life in patients treated with nintedanib in the open-label extension trial, SENSCIS-ON.MethodsPatients with SSc-ILD who completed the SENSCIS

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Hart, Lowell, Seock-Ah Im, Sara Tolaney, et al. "Abstract PS02-01: Efficacy, safety, and quality of life with ribociclib + endocrine therapy in elderly patients with HR+/HER2– advanced breast cancer across the MONALEESA-2, -3, and -7 trials." Cancer Research 84, no. 9_Supplement (2024): PS02–01—PS02–01. http://dx.doi.org/10.1158/1538-7445.sabcs23-ps02-01.

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Abstract Background: Ribociclib (RIB) + endocrine therapy (ET) showed statistically significant progression-free survival (PFS) and overall survival (OS) benefits in MONALEESA-2, -3, and -7 in patients (pts) with HR+/HER2− advanced breast cancer (ABC). Here, we report efficacy, safety, and quality of life (QOL) with RIB + ET in elderly pts in the MONALEESA trials. Methods: Data were pooled from the MONALEESA-2, -3, and -7 trials of pre- and postmenopausal pts with HR+/HER2− ABC treated with first-line RIB + ET or placebo (PBO) + ET. The tamoxifen cohort in MONALEESA-7 and pts with early relaps

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Artz, Andrew S., Brent R. Logan, Xiaochun Zhu, et al. "Pre-Transplant C-Reactive Protein (CRP), Ferritin and Albumin As Biomarkers to Predict Transplant Related Mortality (TRM) after Allogeneic Hematopoietic Cell Transplant (HCT)." Blood 124, no. 21 (2014): 422. http://dx.doi.org/10.1182/blood.v124.21.422.422.

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Abstract HCT entails substantial TRM justifying continued efforts to better risk stratify patients. Single institutional studies have suggested several clinically available biomarkers of CRP, ferritin and albumin influence TRM if not overall survival (OS). We sought to confirm the independent prognostic value of these biomarkers in a large multi-institutional cohort. The study population consisted of 784 adults with AML in remission (80%) or MDS (20%) undergoing unrelated donor HCT between 2008 and 2010 and available cryopreserved samples through the Center for International Blood and Marrow T

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Gossec, L., D. D. Gladman, E. Mcdearmon-Blondell, et al. "AB0550 EFFICACY OF UPADACITINIB IN PATIENTS WITH ACTIVE PSORIATIC ARTHRITIS AND A LOW OR HIGH SWOLLEN JOINT COUNT: A SUBGROUP ANALYSIS OF 2 PHASE 3 STUDIES (SELECT-PsA 1 AND SELECT-PsA 2)." Annals of the Rheumatic Diseases 80, Suppl 1 (2021): 1308.2–1309. http://dx.doi.org/10.1136/annrheumdis-2021-eular.2127.

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Background:Although most patients with psoriatic arthritis (PsA) enrolled in clinical trials have polyarticular arthritis, patients in clinical practice may present with oligoarthritis. Data on the efficacy of Janus kinase inhibitors in patients with PsA with low joint counts are limited.Objectives:To evaluate the efficacy of upadacitinib (UPA) in subgroups of patients with PsA with a low (baseline swollen joint count [SJC] <5) or high (SJC ≥5) SJC (LSJ or HSJ).Methods:Data were pooled across the SELECT-PsA 11 (non-biologic disease-modifying antirheumatic drug [non-bDMARD] inadequate respon

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Grillo, Ana Carolina Angelini, Carolina Araújo Silva, Rafaela Del Piccolo Campos, et al. "ÓBITOS POR MELANOMA NO BRASIL ENTRE 2000 A 2023." Revista ft 29, no. 145 (2025): 56–57. https://doi.org/10.69849/revistaft/ch10202504161956.

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INTRODUÇÃO: O melanoma cutâneo é um dos tipos de câncer mais agressivos e de maior incidência em diversas populações ao redor do mundo, com destaque para os países de alta exposição solar, como o Brasil. Esse câncer origina-se nos melanócitos, células responsáveis pela pigmentação da pele, e sua incidência tem aumentado ao longo das últimas décadas, especialmente em faixas etárias mais avançadas. Fatores como a exposição solar excessiva, histórico familiar e características individuais, como a cor da pele e presença de sinais atípicos, estão entre os principais riscos associados ao desenvolvim

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Rodríguez Salas, G., A. M. Santos, V. Navarro-Compán, et al. "AB1023 THE DIFFERENTIAL CHARACTERISTIC OF SPONDYLOARTHRITIS PATIENTS WHO CANNOT BE CLASSIFIED ACCORDING TO ASAS: RESULTS FROM THE GESPA COLOMBIAN COHORT." Annals of the Rheumatic Diseases 82, Suppl 1 (2023): 1733.2–1734. http://dx.doi.org/10.1136/annrheumdis-2023-eular.5271.

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BackgroundThe Assessment of SpondyloArthritis International Society (ASAS) classification criteria for SpA has changed the approach to the disease, enhancing the performance of the classification process. However, regardless of the ASAS classification criteria were developed according to a global cohort of patients, Latin American patients were not included in a significant number. SpA patients from our region have unique characteristics that may impact the SpA classification. Other alleles than HLA-B27 have been identified, the frequency of HLA-B15 was reported to be 19.1% in the Latin Americ

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Adegbite, Benjamin O., Carlyn Rose Tan, Tala Shekarkhand, et al. "Frailty and Outcomes after Bispecific T-Cell Engager Therapy for Patients with Relapsed/Refractory Multiple Myeloma." Blood 144, Supplement 1 (2024): 4735. https://doi.org/10.1182/blood-2024-201824.

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Introduction: Multiple myeloma (MM) is a disease of the elderly with a median age of 69 years at diagnosis. In addition to advanced age, many of these patients are frail with pre-existing comorbidities and have been historically excluded from clinical trials evaluating cellular immunotherapy including bispecific antibodies (BsAb) for relapsed refractory (RR) settings. It has been shown that chronologic age alone should not be a barrier towards effective treatment modalities, including autologous stem cell transplant and CAR-T. Rather, frailty scores should be incorporated into screening and el

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Combe, B., Y. Tanaka, P. Emery, et al. "POS0679 CLINICAL OUTCOMES UP TO WEEK (W) 48 IN THE ONGOING FILGOTINIB (FIL) LONG-TERM EXTENSION (LTE) TRIAL OF RHEUMATOID ARTHRITIS (RA) PATIENTS (pts) WITH INADEQUATE RESPONSE (IR) TO METHOTREXATE (MTX) INITIALLY TREATED WITH FIL OR ADALIMUMAB (ADA) DURING THE PHASE 3 PARENT STUDY (PS)." Annals of the Rheumatic Diseases 81, Suppl 1 (2022): 615–16. http://dx.doi.org/10.1136/annrheumdis-2022-eular.1641.

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BackgroundThe preferential Janus kinase-1 inhibitor FIL is approved for treatment of moderate to severe active RA in Europe and Japan.ObjectivesEfficacy and safety of FIL were assessed in pts with IR to MTX who completed a Phase 3 trial (NCT02889796)1 and enrolled in an LTE (NCT03025308).MethodsPts completing the PS1 on study drug were eligible to enter the LTE (data cutoff: June 1, 2020). Median exposure: 2.2 years (y). Efficacy data to W48 are reported for 4 treatment groups (all with background MTX): pts receiving FIL 200 mg (FIL200) or FIL 100 mg (FIL100) in the PS and continuing their dos

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Amisha, Fnu, Ziad Abuhelwa, Wenyi Fan, et al. "Predictive Markers for Outcomes after Disease Progression Post BCMA-Directed CAR T-Cell Therapy in Patients with Relapsed or Refractory Multiple Myeloma." Blood 144, Supplement 1 (2024): 2004. https://doi.org/10.1182/blood-2024-211822.

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BACKGROUND Idecabtagene vicleucel (I) and Ciltacabtagene autoleucel (C) are two commercially available BCMA-directed CAR-T cell products initially FDA approved after &gt; 4 lines of therapy in patients with triple class exposed relapsed or refractory multiple myeloma patients (RRMM). Despite a high overall response rate, patients develop progressive disease. Little is known regarding factors associated with outcomes after progression post BCMA-directed CAR T-cell therapy and the optimal management strategy for post progression remains to be elusive. METHODS We conducted a single-center ret

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Winthrop, K., M. H. Buch, J. Curtis, et al. "POS0092 HERPES ZOSTER IN THE FILGOTINIB RHEUMATOID ARTHRITIS PROGRAM." Annals of the Rheumatic Diseases 80, Suppl 1 (2021): 255.1–256. http://dx.doi.org/10.1136/annrheumdis-2021-eular.1408.

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Background:The once daily, oral Janus kinase (JAK)-1 preferential inhibitor filgotinib (FIL) improved signs and symptoms of rheumatoid arthritis (RA) in phase (P)3 trials.1-3 Patients (pts) with RA have increased herpes zoster (HZ) reactivation risk vs the general population. JAK inhibition is associated with increased infection incidence, including HZ.4Objectives:To assess long-term safety of FIL across the global clinical program with respect to HZ.Methods:Pts meeting 2010 ACR/EULAR RA criteria in a pooled analysis of P2 DARWIN 1–2 (D1–2), P3 FINCH 1–3 (F1–3), and long-term extension studies

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Burkhart, Scott O., Christine Ellis, and Troy M. Smurawa. "ACUTE PERFORMANCE ON A VESTIBULAR AND OCULAR MOTOR SCREENER AND RECOVERY FOLLOWING CONCUSSION." Orthopaedic Journal of Sports Medicine 7, no. 3_suppl (2019): 2325967119S0013. http://dx.doi.org/10.1177/2325967119s00136.

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Background: Concussion injuries are synonymous with vestibular impairments and symptoms include dizziness, impaired balance, and problems with gaze stability (Covassin et al., 2014). Common ocular motor impairments after a concussion include convergence/accommodative insufficiencies and saccadic dysfunction (Mucha et al., 2014). Vestibular and ocular motor impairments have been linked to worse outcomes following concussion (Pearce et al., 2015), including prolonged recovery (Corwin et al., 2015). The purpose of the current study was to determine which VOMS impairments were linked with longer r

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Wood, Henry, Lauren Jamieson, Charles Manogaran, et al. "Correlation between the Integrated MDS Flow Cytometry Score and Genomic Abnormalities - a Single Centre Analysis from King's College Hospital." Blood 144, Supplement 1 (2024): 6751. https://doi.org/10.1182/blood-2024-211268.

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Myelodysplastic syndromes (MDS) are diagnosed based on peripheral cytopenias, morphological dysplasia and recurrent genomic abnormalities. Gene variants are found in approximately 90% of cases and cytogenetic abnormalities in 50% (Arber et al, 2022). Genomic abnormalities are key to diagnosis and prognosis (Bernard et al, 2022). The European Leukemia Net international MDS flow cytometry working group has recommended an integrated flow cytometry score (iFS) to support diagnosis of MDS (Oelshlaegel et al 2021; van de Loosdrecht et al, 2021). The score identifies three categories based on the num

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Benton, Christopher B., Peng Qiu, Farhad Ravandi, et al. "Dynamics and Prognostic Impact of Peripheral Blood Blast Clearance in Patients with Acute Myeloid Leukemia (AML) Receiving FLT3 Inhibitor Therapy in Combination with Induction Chemotherapy." Blood 120, no. 21 (2012): 1417. http://dx.doi.org/10.1182/blood.v120.21.1417.1417.

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Abstract Abstract 1417 Background: We have previously shown that for patients with acute myeloid leukemia (AML) treated with induction chemotherapy with cytarabine (ara-C) plus an anthracycline, the day of blast clearance from peripheral blood (PB) is a powerful prognostic marker. Earlier PB blast (but not white blood cell [WBC]) clearance portends improved overall survival (OS). We expanded our investigation to include patients with AML undergoing induction chemotherapy with ara-C (1.5g/m2 ×3 days) plus idarubicin (12mg/m2×3 days) that is, the AI regimen, plus sorafenib (400mg orally twice da

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Melville, A., M. Y. MD Yusof, J. Fitton, et al. "THU0175 REAL-WORLD EXPERIENCE OF SWITCHING FROM ORIGINATOR TO BIOSIMILAR RITUXIMAB IN RHEUMATOID ARTHRITIS." Annals of the Rheumatic Diseases 79, Suppl 1 (2020): 303–4. http://dx.doi.org/10.1136/annrheumdis-2020-eular.4534.

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Background:Pre-clinical and trial data confirm biosimilar rituximab (RTX-B) has equivalent physicochemical properties, function, efficacy and safety as originator (RTX-O)1,2. However, real-world data are lacking, including non-medical switch to RTX-B in patients established on RTX-O. Loss of response (LOR) has been observed following open-label switch to other biosimilars3, and it is unclear how patients who develop LOR after switching should be managed.Objectives:To describe our real-world experience of non-medical switch from RTX-O to RTX-B in RA and explore treatment strategies for patients

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Brown, Jennifer R., Matthew S. Davids, Jordi Rodon, et al. "Update On The Safety and Efficacy Of The Pan Class I PI3K Inhibitor SAR245408 (XL147) In Chronic Lymphocytic Leukemia and Non-Hodgkin’s Lymphoma Patients." Blood 122, no. 21 (2013): 4170. http://dx.doi.org/10.1182/blood.v122.21.4170.4170.

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Abstract Background Constitutive activation of phosphatidylinositol 3-kinase (PI3K)/ mammalian target of rapamycin (mTOR) pathway by various mechanisms has been implicated in the pathogenesis of chronic lymphocytic leukemia (CLL) and non-Hodgkin’s lymphoma (NHL). There is mounting evidence suggesting that along with PI3Kγ, PI3Kα may be involved in CLL/NHL. SAR245408 is a potent and selective inhibitor of all α, γ and δ class I PI3K isoforms. It has been shown to inhibit PI3K signaling and impact tumor growth in preclinical tumor models. The impact of SAR245408 on safety, tolerability, pharmaco

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Merli, Pietro, Annalisa Ruggeri, Mattia Algeri та ін. "Clinical Outcomes after Allogeneic Hematopoietic Stem Cell Transplantation in Patients with Transfusion-Dependent β-Thalassemia Treated at the Bambino Gesù Children's Hospital, Rome, Italy". Blood 134, Supplement_1 (2019): 969. http://dx.doi.org/10.1182/blood-2019-123440.

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β-thalassemia is one of the most common monogenic blood disorders worldwide, and is highly prevalent in Mediterranean countries. Allogeneic hematopoietic stem cell transplantation (allo-HSCT) has been the only curative treatment for transfusion-dependent β-thalassemia (TDT; the most severe disease form) for many years, but it is limited by donor availability and has a significant risk of morbidity and mortality. We conducted a chart review of patients with β-thalassemia who underwent allo-HSCT (N=80) at the Bambino Gesù Children's Hospital, Rome, Italy, between March 2011 and August 2018. Medi

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Abdellatif, A., L. Zhao, P. M. Peloso, et al. "POS1122 PRELIMINARY FINDINGS OF THE PROTECT CLINICAL TRIAL: PEGLOTICASE EFFICACY AND SAFETY IN KIDNEY TRANSPLANT RECIPIENTS." Annals of the Rheumatic Diseases 80, Suppl 1 (2021): 840.2–840. http://dx.doi.org/10.1136/annrheumdis-2021-eular.97.

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Background:The prevalence of gout is high in kidney transplant (KT) recipients (up to 13%), largely because of decreased kidney function and calcineurin inhibitor use.1 Residual chronic kidney disease (CKD) leading to decreased urate lowering therapy clearance and drug interactions make managing gout in KT recipients challenging. Studies show that successful treatment with pegloticase, a pegylated uricase, leads to marked reductions in serum uric acid (sUA)2 and a subsequent decrease in overall urate load and tophi burden.3 However, pegloticase use in solid organ transplant recipients has not

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Korsakova, Y., E. Loginova, E. Gubar, et al. "SAT0424 OBESITY LINKS TO PSORIATIC ARTHRITIS (PsA) ACTIVITY, HIGHER PREVALENCE OF CARDIOMETABOLIC DISORDERS AND WORSE PATIENT REPORTED OUTCOMES (PROs): DATA FROM THE RUSSIAN PsA REGISTRY (RU-PsART)." Annals of the Rheumatic Diseases 79, Suppl 1 (2020): 1166.2–1166. http://dx.doi.org/10.1136/annrheumdis-2020-eular.5538.

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Background:PsA patients (pts) have an increased risk of cardiovascular (CV) and metabolic (Met) disorders due to the combination of inflammation and increased prevalence of traditional CV risk factors. Only limited data are available on Russian PsA pts. Data was collected from 25 rheumatology clinics of the Russian FederationObjectives:to study, in clinical practice, the prevalence of obesity and its association with PsA activity, CV/Met comorbidities and PROsMethods:614 (M/F=331(54%)/283(46%) PsA pts fulfilling the CASPAR criteria were included from the RU-PsART cohort. Mean age 45.2±0.52 yrs

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Spiera, R., M. Kuwana, D. Khanna, et al. "OP0171 PHASE 3 TRIAL OF LENABASUM, A CB2 AGONIST, FOR THE TREATMENT OF DIFFUSE CUTANEOUS SYSTEMIC SCLEROSIS (DCSSC)." Annals of the Rheumatic Diseases 80, Suppl 1 (2021): 102–3. http://dx.doi.org/10.1136/annrheumdis-2021-eular.1795.

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Background:Lenabasum is an oral CB2 agonist that attenuates inflammation and fibrosis in SSc animal models and showed clinical benefit with acceptable safety in a Phase 2 trial in dcSSc.Objectives:Test efficacy and safety of lenabasum in a Phase 3 trial in dcSSc.Methods:Subjects ≥18 years old with disease duration ≤ 6 years were randomized 1:1:1 to lenabasum 5 mg, 20 mg, or placebo (PBO), all BID, with stable background immunosuppressant therapy (IST) allowed. The primary efficacy endpoint was ACR CRISS score, and secondary endpoints were ΔmRSS, ΔHAQ-DI, and ΔFVC, all at Week 52 for lenabasum

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Rajadurai, Pathmanathan, Tatiana Semiglazova, Alinta Hegmane, et al. "Abstract P5-13-25: PIK3CA registry: A noninterventional, descriptive, retrospective cohort study of PIK3CA mutations in patients with hormone receptor-positive (HR+), human epidermal growth factor receptor 2-negative (HER2-) advanced breast cancer (ABC)." Cancer Research 82, no. 4_Supplement (2022): P5–13–25—P5–13–25. http://dx.doi.org/10.1158/1538-7445.sabcs21-p5-13-25.

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Abstract Introduction: PIK3CA mutations (mut) occur in ~40% of patients (pts) with HR+, HER2- ABC, and lead to phosphatidylinositol 3-kinase (PI3K) pathway hyperactivation, endocrine resistance, and poor survival in advanced disease. Alpelisib, an α-selective PI3K inhibitor and degrader, demonstrated efficacy in combination with fulvestrant in the Phase III SOLAR-1 trial in pts with PIK3CA-mut HR+, HER2- ABC. Notably, treatment benefit was not seen in pts without PIK3CA-mut tumors. Expert guidelines now recommend testing for PIK3CA mut at advanced diagnosis; however, data on PIK3CA mut prevale

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Horton, Miles, Becky Leung, Ricky Nelles, et al. "Prior Azacitidine and Ongoing Transfusion Dependence in MDS Patients Are Associated with Inferior Survival after Allogeneic Stem Cell Transplant." Blood 144, Supplement 1 (2024): 7440. https://doi.org/10.1182/blood-2024-209705.

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Background: Allogeneic stem cell transplantation (alloSCT) remains the only curative therapy for myelodysplastic syndromes (MDS). Outcomes in alloSCT for MDS are often pooled with AML, making the interpretation of risk factors and application to clinical practice challenging. Prior studies have demonstrated impact of adverse cytogenetics, molecular mutations, and high-risk subgroups on survival post alloSCT in MDS. Aims: A retrospective study was conducted to describe current transplant practice in Australian centres and analyse outcomes of MDS patients undergoing alloSCT to identify factors p

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Niewerth, Denise, Niels Franke, Gerrit Jansen та ін. "Interferon-γ-Induced Upregulation of Immunoproteasome Subunit Assembly Overcomes Bortezomib Resistance of Leukemia Cell Lines Harbouring Bortezomib-Induced Mutations in Constitutive PSMB5". Blood 120, № 21 (2012): 1346. http://dx.doi.org/10.1182/blood.v120.21.1346.1346.

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Abstract Abstract 1346 Acquired resistance to the proteasome inhibitor (PI) bortezomib (BTZ) is an emerging factor limiting its efficacy in the treatment of hematologic malignancies. The clinical impact of acquired resistance has been shown in Multiple Myeloma (MM) patients who were re-treated with BTZ. Although BTZ-retreatment was found to be effective, the response rate as well as the duration of response were less as compared to initial treatment, indicating the development of BTZ-resistance in a subgroup of patients. In line with that, we previously found increased expression of constituti

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Hong, Seung Pyo, Min Jeong Kim, Allison Belette, Youjin Oh, Sukjoo Cho, and Young Kwang Chae. "238 Meta-analysis on the incidence of hyperprogressive disease during immune checkpoint inhibitor therapy." Journal for ImmunoTherapy of Cancer 9, Suppl 2 (2021): A254—A256. http://dx.doi.org/10.1136/jitc-2021-sitc2021.238.

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BackgroundHyperprogressive disease (HPD) is a distinct pattern of rapid tumor progression observed in patients with cancer who are undergoing immune checkpoint inhibitor therapy. Despite the growing evidence, a universal definition of HPD remains to be established, and incidence rates vary based on the defining criteria. Therefore, a refinement of currently existing criteria is warranted to better characterize this phenomenon and evaluate its incidence.MethodsTwo independent investigators performed a systematic literature search in EMBASE and MEDLINE using keywords selected in Park et al.1: ch

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Venkteswara, Rao Mandalapu, and Yanamala Venakiah. "Electrophoretic Banding Pattern of Esterase Isozymes In Fresh Water Fish Labeo rohita." Biolife 11, no. 1 (2023): 57–61. https://doi.org/10.5281/zenodo.7747466.

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<strong>Abstract</strong> <em>Labeo rohita </em>is most preferred indigenous edible species in most of the countries and the most abundant species in our fresh water rivers, paddy fields and other water channels. Fishes are the excellent models for monitoring environmental contamination in aquatic system. The In our present investigation electrophoretic banding patterns of tissue specific esterases in various tissues i.e. gill, liver, intestine, muscle and brain were investigated in fresh water fish <em>Labeo rohita. </em>The results revealed that the electrophoretic esterase banding patterns

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Warmansyah, Jhoni, Restu Yuningsih, Evi Selva Nirwana, et al. "The Effect of Mathematics Learning Approaches and Self-Regulation to Recognize the Concept of Early Numbers Ability." JPUD - Jurnal Pendidikan Usia Dini 17, no. 1 (2023): 54–81. http://dx.doi.org/10.21009/jpud.171.05.

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The ability to recognize the concept of early numbers in early childhood is very important to develop so that children are ready to take part in learning mathematics at a higher level. This study aims to determine the effect of mathematics learning approaches and self-regulation to recognize the concept of early numbers ability in kindergarten. The study used an experimental method with a treatment design by level 2x2. The sample used was 32 children. Score data, ability to recognize number concepts, analyzed and interpreted. The results showed that: (1) The Realistic Mathematics Education app

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Nurani, Yuliani, Niken Pratiwi, Robinson Situmorang, and Ni Gusti Ayu Made Yeni Lestari. "Children’s Character Learning Model Based on Indonesian Local Wisdom: Implemented to Early Childhood Education in Play Centers." JPUD - Jurnal Pendidikan Usia Dini 18, no. 1 (2024): 99–111. http://dx.doi.org/10.21009/jpud.181.07.

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Character education can equip young children to become Indonesia's golden generation who are superior and skilled in noble work. This research aims to produce an early childhood character learning model based on local Indonesian wisdom through the Playing Center title which will be implemented at Early Childhood Education Institutions (ECE) in Indonesia. This research method uses the steps of the Borg and Gall research and development model. The subjects in this research were 30 teachers from five ECE institutions in the DKI Jakarta area. The data used as the basis for building a framework for

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Vdovychenko, Yu V., L. O. Omelchenko, A. V. Pysarenko, R. M. Makarchuk, N. M. Fursa, and L. V. Vishnevskiy. "CHARACTERISTIC OF THE TAURIDE TYPE OF SOUTH BEEFCATTLE BREED." Animal Breeding and Genetics 52 (November 1, 2016): 12–17. http://dx.doi.org/10.31073/abg.52.02.

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One of the directions of modern breeding programs for native beef breeds of cattle is organization of activities to preserve genetic variability under control of absorptive pressure of initial breeds and inbreeding level. Therefore, the topical is search of alternative ways of improving genetic potential of productivity and its phenotypic realization based on population monitoring organization, substantiation of theoretical and methodological approaches for determining breeding value and analysis of inheritance and consolidation of main breeding traits in beef cattle. Geographically isolated b

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Hens, Luc, Nguyen An Thinh, Tran Hong Hanh, et al. "Sea-level rise and resilience in Vietnam and the Asia-Pacific: A synthesis." VIETNAM JOURNAL OF EARTH SCIENCES 40, no. 2 (2018): 127–53. http://dx.doi.org/10.15625/0866-7187/40/2/11107.

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Climate change induced sea-level rise (SLR) is on its increase globally. Regionally the lowlands of China, Vietnam, Bangladesh, and islands of the Malaysian, Indonesian and Philippine archipelagos are among the world’s most threatened regions. Sea-level rise has major impacts on the ecosystems and society. It threatens coastal populations, economic activities, and fragile ecosystems as mangroves, coastal salt-marches and wetlands. This paper provides a summary of the current state of knowledge of sea level-rise and its effects on both human and natural ecosystems. The focus is on coastal urban

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Джагунова, Олена. "ПРОФЕСІЙНА ПІДГОТОВКА ВЧИТЕЛІВ У СИСТЕМІ ПЕДАГОГІЧНОЇ ОСВІТИ УКРАЇНИ 1930-2020 РР. НА ПРИКЛАДІ УМАНСЬКОГО ПЕДАГОГІЧНОГО УНІВЕРСИТЕТУ: ІСТОРІОГРАФІЧНИЙ АСПЕКТ". Уманська старовина, № 8 (30 грудня 2021): 244–60. http://dx.doi.org/10.31499/2519-2035.8.2021.249995.

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Ключові слова: освіта, вища освіта, педагогічні заклади вищої освіти, Уманський педагогічний університет. Анотація  У статті висвітлено історичні та історіографічні дослідження, які стосуються розвитку та реформування вищої педагогічної освіти загалом та Уманського державного педагогічного університету зокрема. Показано узагальнювальні праці вчених з історії вищої педагогічної освіти, про особливості становлення і розвитку педагогічних інститутів та діяльність їх структурних підрозділів і науково-педагогічних кадрів в Україні, зокрема на Черкащині. Проаналізовано праці, присвячені

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M., N. Abubacker, and Mehala T. "Physico-chemical analysis of textile dye effluent using microbial consortia mediated degradation process." Biolife 5, no. 1 (2022): 60–67. https://doi.org/10.5281/zenodo.7359415.

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<strong>ABSTRACT</strong> Physico-chemical analysis of textile dye effluent have shown higher concentrations of total solids, total suspended solids, total dissolved solids, biological oxygen demand, chemical oxygen demand, dissolved oxygen, total hardness, carbonate, bicarbonate alkalinities, chloride, calcium, magnesium, sodium, sulphate, zinc, chromium, copper and lead was found to be above permissible levels of WHO standards which ensure the presence of pollutant overloaded in the textile effluent. Bacterial consortia was developed with <em>Bacillus subtilis </em>(NCBT 012), <em>Clostridiu

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Wilson, Matthew R., Toby A. Eyre, Amy A. Kirkwood, et al. "Early Integration of High Dose Methotrexate to Frontline DLBCL Therapy Does Not Impact CNS Relapse Compared to End of Treatment Delivery: A Multicentre International Analysis of 1384 Patients." Blood 138, Supplement 1 (2021): 452. http://dx.doi.org/10.1182/blood-2021-144820.

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Abstract Introduction: Central nervous system (CNS) relapse in diffuse large B-cell lymphoma (DLBCL) is uncommon but is associated with poor outcomes. In selected high risk patients (pts), high dose methotrexate (HDMTX) is often used as CNS prophylaxis with frontline (1L) DLBCL therapy despite uncertain efficacy, optimum dose and timing of delivery. A recent UK study (Wilson et al 2020) showed that intercalated HDMTX (i-HDMTX) was associated with increased toxicity and R-CHOP delays compared to end of treatment (EOT) delivery. Although hypothesis generating, the study size was insufficient to

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Cressier, Patrice. "Castillos y fortalezas de Al-Andalus: observaciones historiográficas y preguntas pendientes." Vínculos de Historia Revista del Departamento de Historia de la Universidad de Castilla-La Mancha, no. 11 (June 22, 2022): 116–40. http://dx.doi.org/10.18239/vdh_2022.11.05.

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Aunque la arqueología de Al-Andalus no se constituyó como disciplina propia hasta hace unos cuarenta años, el interés hacia las fortalezas llamadas por entonces “hispano-musulmanas” se manifestó mucho antes, centrado esencialmente en los aspectos arquitectónicos y de poliorcética. Más recientemente, la aproximación al proceso de la fortificación medieval se ha ido diversificando. No son pocos los trabajos que buscan en él unas respuestas a preguntas más ambiciosas, relativas a la organización de la sociedad campesina, a las estructuras de poblamiento y a la ordenación del territorio, o a las f

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