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Journal articles on the topic '338.28 (043.2)'

Author: Grafiati

Published: 30 May 2022

Last updated: 31 July 2025

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1

Zakharia, Yousef, Eric A. Singer, Ryan Ross, et al. "Phase Ib/II study of durvalumab and guadecitabine in advanced kidney cancer Big Ten Cancer Research Consortium BTCRC GU16-043." Journal of Clinical Oncology 39, no. 6_suppl (2021): 328. http://dx.doi.org/10.1200/jco.2021.39.6_suppl.328.

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328 Background: Anti-PD1/PDL1 immune checkpoint inhibition (CPI) is active in advanced clear cell RCC, but not all patients benefit. Preclinical studies with the combination of hypomethylating agents and CPI resulted in reversal of immune evasion and tumor regression. We examined the combination of the hypomethylating agent guadecitabine (subcutaneously on Days 1-5), with the anti-PDL1 antibody durvalumab (intravenously at flat dose of 1500 mg on Day 8) in 28 day cycles in advanced RCC in a single arm trial. Methods: In the phase Ib portion (n=6; presented previously), guadecitabine dosing of

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Martínez, Carmen, Jorge Gayoso, Carmen Canals, et al. "Post-Transplantation Cyclophosphamide-Based Haploidentical Transplantation as Alternative to Matched Sibling or Unrelated Donor Transplantation for Hodgkin Lymphoma: A Registry Study of the Lymphoma Working Party of the European Society for Blood and Marrow Transplantation." Journal of Clinical Oncology 35, no. 30 (2017): 3425–32. http://dx.doi.org/10.1200/jco.2017.72.6869.

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Purpose To compare the outcome of patients with Hodgkin lymphoma who received post-transplantation cyclophosphamide–based haploidentical (HAPLO) allogeneic hematopoietic cell transplantation with the outcome of patients who received conventional HLA-matched sibling donor (SIB) and HLA-matched unrelated donor (MUD). Patients and Methods We retrospectively evaluated 709 adult patients with Hodgkin lymphoma who were registered in the European Society for Blood and Marrow Transplantation database who received HAPLO (n = 98), SIB (n = 338), or MUD (n = 273) transplantation. Results Median follow-up

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de Vries, Joost C., Maaike K. van Gelder, Anneke S. Monninkhof, et al. "A Uremic Pig Model for Peritoneal Dialysis." Toxins 14, no. 9 (2022): 635. http://dx.doi.org/10.3390/toxins14090635.

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With increasing interest in home dialysis, there is a need for a translational uremic large animal model to evaluate technical innovations in peritoneal dialysis (PD). To this end, we developed a porcine model with kidney failure. Stable chronic kidney injury was induced by bilateral subtotal renal artery embolization. Before applying PD, temporary aggravation of uremia was induced by administration of gentamicin (10 mg/kg i.v. twice daily for 7 days), to obtain uremic solute levels within the range of those of dialysis patients. Peritoneal transport was assessed using a standard peritoneal pe

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Снопков, В. В., С. В. Байко, and Н. И. Тур. "Acute Pyelonephritis in Children: Predictors of Recurrence and Effectiveness of Anti-Relapse Therapy." Педиатрия. Восточная Европа, no. 2 (July 4, 2023): 175–86. http://dx.doi.org/10.34883/pi.2023.11.2.002.

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Введение. Острый пиелонефрит (ОП) считается одним из самых серьезных бактериальных заболеваний в детском возрасте. Эпизод ОП и его рецидив ассоциированы с развитием нефросклероза, артериальной гипертензии и хронической болезни почек. Цель. Определить предикторы рецидивирования ОП у детей и оценить эффективность противорецидивной терапии. Материалы и методы. Проведен ретроспективный анализ 563 медицинских карт стационарных пациентов с диагнозом ОП во 2-й городской детской клинической больнице г. Минска за период 2017–2021 гг. Все дети были разделены на 2 группы: 1-я – младше 2 лет (n=225) с мед

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Anh, Trịnh Thị Lan, Nguyễn Đức Thành та Chu Huyền Xiêm. "Sự gắn kết với tổ chức của nhân viên y tế và một số yếu tố ảnh hưởng tại Bệnh viện đa khoa Sóc Sơn, Hà Nội năm 2024". Journal of Health and Development Studies 08, № 05 (2024): 72–80. https://doi.org/10.38148/jhds.0805skpt24-034.

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Mục tiêu: Nghiên cứu nhằm mô tả thực trạng sự gắn kết với tổ chức của nhân viên y tế và một số yếu tố ảnh hưởng tại Bệnh viện đa khoa Sóc Sơn, Hà Nội năm 2024. Phương pháp nghiên cứu: Thiết kế nghiên cứu mô tả cắt ngang, kết hợp định lượng và định tính được tiến hành phát vấn 338 nhân viên y tế, phỏng vấn sâu và thảo luận nhóm với 28 cán bộ lãnh đạo quản lý, nhân viên đang làm việc và nhân viên đã nghỉ việc tại Bệnh viện đa khoa Sóc Sơn, Hà Nội từ tháng 2 - 5/2024. Kết quả: Sự gắn kết với tổ chức đạt điểm trung bình 4,33 (±0,55), khía cạnh lòng trung thành là 4,29 (±0,61), niềm tự hào là 4,26

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Alvarez Reguera, C., A. Herrero Morant, L. Sanchez Bilbao, et al. "SAT0508 DIAGNOSIS OF BEHÇET’S DISEASE: COMPARISON OF TWO SETS OF CLASSIFICATION CRITERIA. APPLICATION IN 111 PATIENTS OF A WELL-DEFINED POPULATION." Annals of the Rheumatic Diseases 79, Suppl 1 (2020): 1210.3–1210. http://dx.doi.org/10.1136/annrheumdis-2020-eular.5166.

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Background:Behçet’s disease (BD) is a systemic, chronic, relapsing vasculitis with no pathognomonic diagnostic test. The most widely used classification criteria are those of the International Study Group (ISG) for BD (1). These criteria were repeatedly found to have low sensitivity. Therefore, the International Criteria for Behçet’s Disease (ICBD) were published in 2014 (2).Objectives:To compare the ISG with ICBD diagnostic criteria for BD.Methods:The study included all consecutive 111 patients diagnosed with definitive or possible BD by expert rheumatologists. They were diagnosed at a well-d

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Bianchi, Paola, Elisa Fermo, Fulvio Mozzi, Maurizio Marconi, and Alberto Zanella. "Presence of JAK2 V617F Mutation in Peripheral Blood of Blood Donors with Upper-Limit Hematocrit and Platelet Values." Blood 110, no. 11 (2007): 2533. http://dx.doi.org/10.1182/blood.v110.11.2533.2533.

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Abstract The somatic mutation V617F of JAK2 gene has been identified as a pathogenic factor in typical chronic myeloproliferative diseases (MPDs), in particular polycythemia vera, essential thrombocythemia, and myelofibrosis with myeloid metaplasia. Recently, two studies showed the presence of this mutation also in 37/3935 subjects with non haematological diseases (Xu et al, 2006) and 5/52 healthy donors (Sidon et al, 2006), suggesting that V617F mutation may occur in the absence of MPD phenotype and that probably is not sufficient per se to induce MPDs. The aim of this study was to search for

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Newton, Kathryn T., and Aaron Ashley. "Introducing the Interdisciplinary Nature of Health Care Through Case Study Models." Journal of Education and Training Studies 8, no. 1 (2019): 20. http://dx.doi.org/10.11114/jets.v8i1.4600.

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Interprofessional education (IPE) is a critical area needed to improve the quality of healthcare. Stereotypes of other disciplines persist by healthcare workers, limiting the ability to work as a team. Knowledge of roles of healthcare professions is a key competency of IPE. An online, 12-week course was developed to introduce students to the interdisciplinary nature of healthcare through case study models. Through built-in links, students explore medical terminology, diagnostic testing, pathophysiology, treatment, and health professionals who work as a team to diagnose and treat the patient. A

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Komrokji, Rami S., Muhammad Ammad-ud-din, Najla H. Al Ali, et al. "Hematological Response to Frontline Treatment in Lower Risk Myelodysplastic Syndromes (LRMDS) Is Associated with Better Overall Survival." Blood 142, Supplement 1 (2023): 1867. http://dx.doi.org/10.1182/blood-2023-186843.

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Background The majority of LRMDS patients (pts) (70%) do not progress but unfortunately succumb to complications related to cytopenia, namely anemia and red blood cell transfusion dependency (RBC-TD) or their interplay with co-morbidities. RBC-TD is associated with worse outcome reflecting bone marrow failure and long-term sequela of RBC-TD. There is growing evidence that response to treatment and RBC transfusion independence (TI) are associated with favorable outcome. In lieu of 2 recent randomized clinical trials demonstrating efficacy of luspatercept & imetelstat in LRMDS, we assessed t

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Faustini, Giulia, Claudia Maria Tucciarone, Giovanni Franzo, et al. "Molecular Survey on Porcine Parvoviruses (PPV1-7) and Their Association with Major Pathogens in Reproductive Failure Outbreaks in Northern Italy." Viruses 16, no. 1 (2024): 157. http://dx.doi.org/10.3390/v16010157.

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Successful reproductive performance is key to farm competitiveness in the global marketplace. Porcine parvovirus 1 (PPV1) has been identified as a major cause of reproductive failure, and since 2001 new species of porcine parvoviruses, namely PPV2–7, have been identified, although their role is not yet fully understood yet. The present study aimed to investigate PPVs’ presence in reproductive failure outbreaks occurring in 124 farms of northern Italy. Fetuses were collected from 338 sows between 2019 and 2021 and tested for PPVs by real-time PCR-based assays and for other viruses responsible f

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Desjardins, Marie-Pier, Audrey Hébert, Anie Lapointe, et al. "Clinical Outcomes of Neonatal Central Line-Related Thrombosis: A Multicentric Retrospective Cohort Study." Blood 144, Supplement 1 (2024): 298. https://doi.org/10.1182/blood-2024-205424.

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Introduction: Neonates are particularly at risk of thromboembolism (TE), especially neonates requiring central lines. Management of neonatal TE is particularly complex, as the higher risk of bleeding must be balanced with the thrombotic risks, including organ dysfunction, post-thrombotic syndrome and death. The objectives of this study are to describe the treatment modalities and to compare the effectiveness and safety between antithrombotic treatment modalities among neonates with central line-related TE. Methods: A multicentric retrospective cohort study enrolled neonates ≤28 days of life re

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Dykstra, Rachel, Panagiotis Koutakis, and Nicholas Hanson. "Relationship Between Physical Fitness Variables and Reaction Time in eSports Gamers." International Journal of eSports Research 1, no. 1 (2021): 1–14. http://dx.doi.org/10.4018/ijer.288540.

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eSports gaming requires quick and accurate reactions in response to complex visual stimuli for optimal performance. The purpose of this study was to examine the relationship between components of physical fitness and reaction time (RT) in eSports gamers. 27 eSports gamers participated. Visit 1 included physical fitness assessments. Visit 2 included a familiarization with the Stroop Task. During Visit 3, subjects completed the Stroop Task again; data from this visit was used for analyses. For congruent, incongruent and control trials, an inverse efficiency score (IES) was calculated. Pearson co

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Volkova, Olga, Victor Salomatin, and Alexey Ryadnov. "Diet nutrition digestibility and usage by broilers in soldering complex food additive." Poultry and Chicken Products 26, no. 4 (2024): 18–20. http://dx.doi.org/10.30975/2073-4999-2024-26-4-18-20.

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The research results have been shown in the paper on the complex food additive at the base of beta-carotene “BetaLad” influence on diet nutrients digestion and using by cross “Ross-308” broilers since 1 to 42 days of life (100 broilers in the group. Complex “BetaLad” food additive introduction into drinking water have been established to increase feed nutrients digestibility and using in comparison with control group (for 100 broilers): 1 group — 1 ml 1–28 days and 2 ml 29–40 days; 2 group — 2 ml 1–28 days and 4 ml 29–40 days; 3 group — 3 ml 1–28 days and 6 ml 29–40 days. Feed dry matter diges

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Rivera, Fernanda Estefanía, Carolina Moreno Licea, Heriberto Medina Franco, et al. "Prevention of breast cancer in the general population: Is it a cultural issue?" Journal of Clinical Oncology 39, no. 15_suppl (2021): e22511-e22511. http://dx.doi.org/10.1200/jco.2021.39.15_suppl.e22511.

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e22511 Background: Since 2006 breast cancer has been the main cause of cancer mortality in Mexican women representing 14% of cancer related deaths. In Mexico the incidence and mortality of breast cancer have increased in recent decades and will continue to rise. Despite the vast information media on the prevention of this cancer the diagnosis of between 50 - 70% of cases is carried out in advanced stages probably due to a limited understanding of knowledge and practices of early prevention for breast cancer. Methods: The study universe was 375 Mexican women between 30 - 58 years of age of any

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Farikha, Afifah Nurul, Agus Rusgiyono, and Triastuti Wuryandari. "ESTIMASI RISIKO PORTOFOLIO SAHAM MENGGUNAKAN METODE VALUE-AT-RISK (VaR) DENGAN PENDEKATAN GARCH-COPULA." Jurnal Gaussian 13, no. 2 (2024): 328–38. https://doi.org/10.14710/j.gauss.13.2.328-338.

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Indonesia's economic development has recently experienced turmoil due to the pandemic Covid-19 which affects capital market condition, so it is necessary to analyze characteristics of stock prices and returns also the investment risks. Investment risk measurement using Value at Risk (VaR) estimation will be determined by simulation Monte Carlo with GARCH-Copula approach. This research will use BRPT and ICBP stock data for the period before the Covid-19 pandemic, January 2, 2017 - February 28, 2020 and the period after the Covid-19 pandemic, March 2, 2020 - February 28, 2023.The best model of c

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Roeker, Lindsey Elizabeth, Alvaro Jose Alencar, Guru Subramanian Guru Murthy, et al. "A first-in-human phase 1 study of oral LOXO-338, a selective BCL2 inhibitor, in patients with advanced hematologic malignancies (trial in progress)." Journal of Clinical Oncology 40, no. 16_suppl (2022): TPS7582. http://dx.doi.org/10.1200/jco.2022.40.16_suppl.tps7582.

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TPS7582 Background: B-cell lymphoma 2 (BCL2) is a key regulator of apoptosis and provides protection from cell death in many hematologic malignancies. LOXO-338 is an orally bioavailable small molecule inhibitor of BCL2, developed to achieve selectivity over BCL-xL and thus avoid dose-limiting thrombocytopenia associated with BCL-xL inhibition. In preclinical studies, LOXO-338 showed a favorable pharmacological profile, selectively inhibited BCL2, and was well-tolerated in vivo. LOXO-338 also demonstrated dose-dependent tumor growth inhibition in various murine xenograft models and showed impro

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Roeker, Lindsey Elizabeth, Alvaro Jose Alencar, Guru Subramanian Guru Murthy, et al. "A first-in-human phase 1 study of oral LOXO-338, a selective BCL2 inhibitor, in patients with advanced hematologic malignancies (trial in progress)." Journal of Clinical Oncology 40, no. 16_suppl (2022): TPS7582. http://dx.doi.org/10.1200/jco.2022.40.16_suppl.tps7582.

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TPS7582 Background: B-cell lymphoma 2 (BCL2) is a key regulator of apoptosis and provides protection from cell death in many hematologic malignancies. LOXO-338 is an orally bioavailable small molecule inhibitor of BCL2, developed to achieve selectivity over BCL-xL and thus avoid dose-limiting thrombocytopenia associated with BCL-xL inhibition. In preclinical studies, LOXO-338 showed a favorable pharmacological profile, selectively inhibited BCL2, and was well-tolerated in vivo. LOXO-338 also demonstrated dose-dependent tumor growth inhibition in various murine xenograft models and showed impro

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Khalid, Toumi. "Achieving >28% power conversion efficiency in a-Si:H/c-Si solar cells through emitter optimization." Brazilian Journal of Technology 7, no. 4 (2024): e76101. https://doi.org/10.38152/bjtv7n4-043.

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Heterojunction solar cell efficiency is crucial for performance and commercial viability. This study investigates hydrogenated microcrystalline silicon (μc-Si:H), hydrogenated nanocrystalline silicon (nc-Si:H), and hydrogenated amorphous silicon germanium (a-SiGe:H) as p-type emitter layers in a-Si:H/c-Si heterojunction solar cells, examining their influence on short-circuit current density (Jsc), open-circuit voltage (Voc), fill factor (FF), and power conversion efficiency (PCE). Considering the reported effects of hydrogen dilution and substrate temperature on the optoelectronic properties o

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Kanaya, Noriaki, Brad Gable, Peter J. Wickley, Paul A. Murray, and Derek S. Damron. "Experimental Conditions Are Important Determinants of Cardiac Inotropic Effects of Propofol." Anesthesiology 103, no. 5 (2005): 1026–34. http://dx.doi.org/10.1097/00000542-200511000-00017.

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Background The rationale for this study is that the depressant effect of propofol on cardiac function in vitro is highly variable but may be explained by differences in the temperature and stimulation frequency used for the study. Both temperature and stimulation frequency are known to modulate cellular mechanisms that regulate intracellular free Ca2+ concentration ([Ca2+]i) and myofilament Ca2+ sensitivity in cardiac muscle. The authors hypothesized that temperature and stimulation frequency play a major role in determining propofol-induced alterations in [Ca2+]i and contraction in individual

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Labbé, J. P., S. Lelievre, M. Boyer, and Y. Benyamin. "Interaction of skeletal-muscle myosin subfragment-1 with the actin-(338-348) peptide." Biochemical Journal 299, no. 3 (1994): 875–79. http://dx.doi.org/10.1042/bj2990875.

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The data presented here confirm and provide further experimental evidence that rabbit skeletal-muscle myosin subfragment-1 (S-1) binds to the postulated actin-(338-348) hydrophobic segment [Kabsch, Mannherz, Suck, Pai and Holmes (1990) Nature (London) 347, 37-44] with high affinity in the absence and presence of MgATP. The apparent dissociation constant of the S-1 interaction (5.5 x 10(-7) M) with the actin-(338-348) peptide was of the same order of magnitude as that of the actin-(18-28) binding site (2 x 10(-6) M). In similar conditions, fragmented (27 kDa-50 kDa-20 kDa) S-1 also bound to the

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Eubank, Taryn A., Katherine Perez, William L. Musick, and Kevin W. Garey. "338. Multicenter Evaluation of Superinfection Occurrence and Impact on Clinical Outcomes in Patients with COVID-19." Open Forum Infectious Diseases 8, Supplement_1 (2021): S273—S274. http://dx.doi.org/10.1093/ofid/ofab466.539.

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Abstract Background The coronavirus disease 2019 (COVID-19), caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), spread globally throughout late 2019. During this pandemic, concern for bacterial and fungal superinfections has been present during the treatment of these patients. Methods Hospitalized, adult patients with laboratory confirmed and symptomatic COVID-19 disease admitted between March 12, 2020 and May 31, 2020 were eligible for inclusion in this study. Data was obtained from electronic medical records and the hospital system’s clinical surveillance progr

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Scott, D. P., P. R. Teasdale, and R. Swaminathan. "Value of measuring C-terminal parathyrin in differential diagnosis of hypercalcemia." Clinical Chemistry 31, no. 11 (1985): 1838–40. http://dx.doi.org/10.1093/clinchem/31.11.1838.

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Abstract We measured calcium, phosphate, chloride, albumin, C-terminal parathyrin, and beta 2-microglobulin in serum from 102 hypercalcemic patients: 42 with primary hyperparathyroidism and 60 with neoplasia. The calcium concentrations and the discriminant function index of Johnson et al. (Clin Chem 28, 333-338, 1982) were higher in malignant hypercalcemia than in primary hyperparathyroidism. The diagnostic efficiency of the index and of parathyrin concentration was 82% and 78%, respectively. Using the ratio of parathyrin to beta 2-microglobulin increased the diagnostic efficiency to 98%; the

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Torres Júnior, J. R. S., M. F. A. Pires, W. F. Sá, et al. "318 EFFECT OF MATERNAL HEAT STRESS ON OOCYTE QUALITY AND IN VITRO COMPETENCE IN BOS INDICUS CATTLE." Reproduction, Fertility and Development 19, no. 1 (2007): 274. http://dx.doi.org/10.1071/rdv19n1ab318.

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High temperatures can be harmful to the competence of cumulus–oocyte complexes and to embryo development (Al-Katanani et al. 2002 J. Dairy Sci. 85, 390–396). The aim of this study was to evaluate the effect of maternal heat stress on in vitro embryo yield. Ten multiparous nonlactating Gir (Bos indicus) cows were kept in tie stalls for an adaptive period of 28 days [pre-heat-stress period (PRE-HS)/Days -28 to -1]. Cows were subjected to 2 OPU (ovum pickup) sessions (Days -14 and -7). In the heat-stress period (HS; Days 0 to 28), cows were divided into control (C: n = 5) and heat-stressed (HS: n

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Alencar, Alvaro J., Lindsey E. Roeker, Marc Hoffmann, et al. "A First-in-Human Phase 1 Study of Oral LOXO-338, a Selective BCL2 Inhibitor, in Patients with Advanced Hematologic Malignancies (Trial in Progress)." Blood 138, Supplement 1 (2021): 2424. http://dx.doi.org/10.1182/blood-2021-145380.

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Abstract Background: B-cell lymphoma 2 (BCL2) is a key regulator of apoptosis and provides protection from cell death in many hematological malignancies. The BCL2 inhibitor venetoclax is approved for the treatment of CLL/SLL and acute myeloid leukemia and has activity in other lymphoid malignancies. LOXO-338 is a novel, orally bioavailable small molecule inhibitor of BCL2, designed to achieve selectivity over BCL-xL and thus avoid dose-limiting thrombocytopenia associated with BCL-xL inhibition. In preclinical studies, LOXO-338 showed a favorable pharmacological profile, selectively inhibited

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Morales-Sánchez, Martha Alejandra, María Fernanda Villegas-Calzada, Graciela Astrid Acatitla-Acevedo, Nabil De Anda-Ortiz, and Maria Luisa Peralta-Pedrero. "567 - Prognostic factors in pediatric patients with vitiligo." British Journal of Dermatology 190, Supplement_2 (2024): ii70—ii71. http://dx.doi.org/10.1093/bjd/ljad498.072.

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Abstract Introduction Vitiligo is a pigmentary disorder, and its prevalence reaches 2.16% in children.(1) Childhood vitiligo differs from adult vitiligo in clinical characteristics such as higher incidence in females, higher prevalence of segmental presentation and lower association with autoimmune disorders. (2) The course of vitiligo is unpredictable, the disease may regress, stabilize, progress and exacerbate. (3) Few studies of the course of vitiligo have been published. Objectives The aim of this study was to identify the clinical characteristics associated with the progression of vitilig

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Lin, Rongbo, Ye Zaisheng, Zhuo Changhua, et al. "Tislelizumab combined with POFI (irinotecan, paclitaxel, oxaliplatin and 5-FU/levoleucovorin) as first-line treatment of advanced gastric/gastroesophageal junction adenocarcinoma (AGC): Preliminary results of a single-arm, open-label phase I/II trial (SYLT-023)." Journal of Clinical Oncology 42, no. 3_suppl (2024): 331. http://dx.doi.org/10.1200/jco.2024.42.3_suppl.331.

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331 Background: Tislelizumab is a humanised IgG4 monoclonal antibody with high affinity and binding specificity for PD-1. Combined with fluoropyrimidine + platinum (XELOX or FP), it is approved in China as first-line treatment of advanced gastric cancer (AGC). Both irinotecan and paclitaxel have also shown antitumor activity in advanced gastric/gastroesophageal junction adenocarcinoma. In this phase I/II study, we explore the safety, tolerability, and efficacy of tislelizumab + irinotecan, paclitaxel, oxaliplatin and 5-FU (POFI) as first-line treatment of HER-2 negative, pMMR AGC. Methods: In

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Wickert, J., G. Beyerle, R. König, et al. "GPS radio occultation with CHAMP and GRACE: A first look at a new and promising satellite configuration for global atmospheric sounding." Annales Geophysicae 23, no. 3 (2005): 653–58. http://dx.doi.org/10.5194/angeo-23-653-2005.

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Abstract. CHAMP (CHAllenging Minisatellite Payload) and GRACE (Gravity Recovery And Climate Experiment) formed a satellite configuration for precise atmospheric sounding during the first activation of the GPS (Global Positioning System) radio occultation experiment aboard GRACE on 28 and 29 July 2004. 338 occultations were recorded aboard both satellites, providing globally distributed vertical profiles of refractivity, temperature and specific humidity. The combined set of CHAMP and GRACE profiles shows excellent agreement with meteorological analysis. Almost no refractivity bias is observed

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Yoon, Eun-Jeong, Eun Hee Lee, Dong Hwi Hwang, Hyukmin Lee, Je-Hyun Baek, and Seok Hoon Jeong. "Direct detection of intact Klebsiella pneumoniae carbapenemases produced by Enterobacterales using MALDI-TOF MS." Journal of Antimicrobial Chemotherapy 75, no. 5 (2020): 1174–81. http://dx.doi.org/10.1093/jac/dkaa007.

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Abstract Objectives A MALDI-TOF MS-based identification method for KPC-producing Enterobacterales was developed. Methods The molecular mass of the intact KPC-2 polypeptide was estimated for blaKPC-2 transformants using MALDI Microflex and the exact mass was confirmed by LC and a high-resolution MS/MS system. A total of 1181 clinical Enterobacterales strains, including 369 KPC producers and 812 KPC non-producers, were used to set up the methodology and the results were compared with those from PCR analyses. For external validation, a total of 458 Enterobacterales clinical isolates from a genera

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Ninomiya, Masashi, Tsutomu Nishizawa, Masaharu Takahashi, Felipe R. Lorenzo, Tooru Shimosegawa, and Hiroaki Okamoto. "Identification and genomic characterization of a novel human torque teno virus of 3.2 kb." Journal of General Virology 88, no. 7 (2007): 1939–44. http://dx.doi.org/10.1099/vir.0.82895-0.

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In the process of searching for the recently described small anelloviruses 1 and 2 (SAVs) with the genomic DNA length of 2.2 or 2.6 kb in human sera, we isolated a novel virus with its genomic organization resembling those of torque teno virus (TTV) of 3.8–3.9 kb and torque teno mini virus (TTMV) of 2.8–2.9 kb. The entire genomic sequence of three isolates (MD1-032, MD1-073 and MD2-013), which comprised 3242–3253 bases and exhibited 76–99 % identities with the SAVs within the overlapping sequence, was determined. Although the MD1-032, MD1-073 and MD2-013 isolates differed by 10–28 % from each

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Susilowati, Tri, Ririn Wardani, and Ida Nur Imamah. "Hubungan Tingkat Pengetahuan dengan Perilaku Penanganan Gawat Darurat Hipotermi pada Pendaki Gunung di Organisasi Primapala Ampel Kabupaten Boyolali." Jurnal Ners dan Kebidanan (Journal of Ners and Midwifery) 7, no. 1 (2020): 037–43. http://dx.doi.org/10.26699/jnk.v7i1.art.p037-043.

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Latar Belakang : Pendaki gunung dan hipotermi merupakan sebuah hubungan yang sangat terkait dalam pendakian. Cuaca buruk di puncak gunung Merbabu menyebabkan 7 pendaki harus dievakuasi karena mengalami hipotermi saat mendaki. Kondisi tubuh yang terlalu lama kedinginan, khususnya dalam cuaca berangin dan hujan dapat menyebabkan mekanisme pemanasan tubuh terganggu. Pentingnya pengetahuan pada pendaki dapat menjadikan pendaki tersebut terhindar dari hipotermi, tetapi tak jarang para pendaki menganggap remeh dan tidak peduli. Tujuan Penelitian: Mengetahui hubungan tingkat pengetahuan dengan perila

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Kabbinavar, F. F., S. Srinivas, R. J. Hauke, et al. "A phase I trial of combined tivozanib (AV-951) and temsirolimus therapy in patients (pts) with renal cell carcinoma (RCC)." Journal of Clinical Oncology 29, no. 7_suppl (2011): 330. http://dx.doi.org/10.1200/jco.2011.29.7_suppl.330.

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330 Background: Tivozanib, a potent and selective tyrosine kinase inhibitor (TKI) of vascular endothelial growth factor receptors (VEGFR)-1, -2, and -3, has demonstrated antitumor activity in a phase II study in RCC (Proceedings of ASCO 2009, Abstract 5032). Temsirolimus, a mammalian target of rapamycin (mTOR) inhibitor, is approved for treatment of advanced RCC. This phase Ib open-label study examined combination tivozanib and temsirolimus therapy in pts with advanced RCC to determine the safety and tolerability, maximum tolerated dose (MTD), and clinical activity of this drug regimen. Method

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Nardi, P., D. Buioni, V. Labriola, et al. "LOWER VALUES OF INTRAOPERATIVE CORONARY GRAFTS TRANSIT TIME FLOW MEASUREMENTS OBSERVED IN FEMALE GENDER DO NOT AFFECT EARLY OUTCOME AFTER CABG." Journal of Cardiovascular Medicine 25, Supplement 1 (2024): e23. https://doi.org/10.2459/01.jcm.0001096384.75280.08.

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Background and Aim: Intraoperative transit time flow measurement (TTFM) of left internal thoracic (L-ITA) and saphenous vein (SV) grafts can improve clinical outcome after CABG. We have retrospectively investigated if there were differences in female and male gender on TTFM–flow (mL/min) and pulsatility index (PI-value)– after CABG, and early outcome. Methods: Between September 2022 and September 2023, TTFM was performed in 101 consecutive patients (21 females, 20%, 80 males, 80%) undergoing CABG, isolated (n=75) or associated with other procedures (n=26). Results: No differences were observed

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Che, Tung M. "Use of Marine Sulfated Polysaccharide as an alternative to antibiotics in the diet of broilers." Journal of Agriculture and Development 18, no. 03 (2019): 21–26. http://dx.doi.org/10.52997/jad.4.03.2019.

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The objective of the experiment was to evaluate the efficacy of Marine Sulfated Polysaccharide enhanced by a blend of organic acids (AseaD) as an alternative to colistin in the diet of broilers. A total of two hundred and sixteen one-day-old male chicks (Ross 308, initial body weight: 42.25 ± 0.42 g/bird) were randomly assigned to 1 of 2 treatments each represented with 12 replicate cages of 9 birds. The dietary treatments included (1) basal diet with antibiotic (Control, basal diet + 20 ppm colistin) and (2) basal diet without antibiotic + 0.3% AseaD (AseaD). Birds in the control were fed a b

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Aguirre, Luis E., Jan Philipp Bewersdorf, Yiwen Liu, et al. "Comparative Analysis of Outcomes with HMA Plus Venetoclax Vs Intensive Chemotherapy in AML Patients Harboring Very-High Risk Cytogenetics." Blood 144, Supplement 1 (2024): 4267. https://doi.org/10.1182/blood-2024-202744.

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Background: Dismal survival outcomes are characteristic of pts with AML harboring very-high risk cytogenetics (vHRC), which can be attributed to aggressive disease biology and low and poorly durable response rates to conventional cytotoxic chemotherapy. Allogeneic hematopoietic stem cell transplant (alloSCT) is the preferred treatment strategy after major disease reduction with initial chemotherapy. However, it is unclear whether pts with AML-vHRC should be treated with intensive chemotherapy (IC) or hypomethylating agents plus venetoclax (HMA+ven) to achieve such responses. In this large mult

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Li, Eric, James A. Proudfoot, Nalin Kundu, et al. "Association of transcriptomic biomarkers with adverse pathologic features at radical prostatectomy among active surveillance eligible men." Journal of Clinical Oncology 42, no. 4_suppl (2024): 338. http://dx.doi.org/10.1200/jco.2024.42.4_suppl.338.

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338 Background: Active surveillance (AS) is the preferred management for men with NCCN very low or low risk prostate cancer (PCa) and may be considered for select favorable intermediate risk PCa. AS can be associated with significant grade reclassification and progression to treatment, adverse pathology at radical prostatectomy (RP), and need for salvage therapy. Genomic transcriptomic biomarkers have been shown to be prognostic and potentially predictive of treatment response in the locally advanced and metastatic setting. The potential of transcriptomic biomarkers to identify durable AS cand

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Ambarwati, Dinar, Ida H. Soemantri, Dwinita W. Utami, Aniversari Apriana, and Sugiono Moeljopawiro. "Rice Anther Culture to Develop Double Haploid Population and Blast Resistant Lines." Jurnal AgroBiogen 5, no. 2 (2009): 71. http://dx.doi.org/10.21082/jbio.v5n2.2009.p71-77.

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<p>Penyakit blas pada padi yang disebabkan<br />oleh cendawan Pyricularia grisea, merupakan salah satu<br />kendala dalam produksi beras. Sumber gen ketahanan terhadap<br />penyakit blas dijumpai pada spesies padi liar Oryza<br />rufipogon. Populasi silang ganda (BC2F3) turunan IR64 dan<br />O. rufipogon mempunyai QTL untuk sifat ketahanan terhadap<br />penyakit blas. Untuk mempercepat perolehan tanaman<br />homosigot dari populasi tersebut, dilakukan kultur anter<br />pada dua media induksi kalus: I1 (N6 + NAA 2 mg/l + kinetin<br />0

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LoConte, Noelle K., Tabraiz Aijaz Mohammed, Emily Winslow, et al. "Effect of neoadjuvant therapy in patients with resected pancreatic adenocarcinoma." Journal of Clinical Oncology 32, no. 3_suppl (2014): 338. http://dx.doi.org/10.1200/jco.2014.32.3_suppl.338.

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338 Background: Retrospective data suggest that neoadjuvant therapy in patients with resectable pancreatic cancer may improve the R0 resection rate and potentially survival. We examined the impact of neoadjuvant therapy on survival rates at a population level for patients with resected pancreatic adenocarcinoma. Methods: Treatment and outcome data were obtained from the Surveillance, Epidemiology and End Results (SEER) Medicare database for patients with pancreatic adenocarcinoma, who underwent a curative intent pancreatectomy from 2001-2007. Patients were stratified by treatment (neoadjuvant

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Niraj, S.Topare, J. Raut Sunita, V. Khedkar Satish, and C. Renge Vilas. "A study of process variables for the photo-catalytic degradation of rhodamine-B using TiO2 and Nb2O5." Journal of Indian Chemical Society Vol. 90, Dec 2013 (2013): 2193–98. https://doi.org/10.5281/zenodo.5793732.

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Department of Chemical Engineering, Bharati Vidyapeeth Deemed University, College of Engineering, Pune-411 043, Maharashtra, India <em>E-mail</em> : nirajtopare06@gmail.com Department of Chemical Engineering, College of Engineering & Technology, Akola-444 I 04, Maharashtra, India <em>Manuscript received online 24 November 2012, revised 28 December 2012, accepted 08 January 2013</em> This study involves the photo-catalytic degradation of rhodamine-B (RB) employing heterogeneous photo-catalytic process. Photo-catalytic activity of different semiconductors such as titanium dioxide (TiO<sub>2<

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Guenette, Jordan A., Andrea M. Martens, Anne L. Lee, et al. "Variable effects of respiratory muscle training on cycle exercise performance in men and women." Applied Physiology, Nutrition, and Metabolism 31, no. 2 (2006): 159–66. http://dx.doi.org/10.1139/h05-016.

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Respiratory muscle training (RMT) has been proposed as an effective means to increase the strength of the inspiratory muscles and improve exercise performance. The purpose of this study was to examine the effect of RMT on cycling time to exhaustion (TTE) and to determine any potential sex effect. We hypothesized that RMT would improve maximal inspiratory pressure (MIP) and TTE to a similar degreee in men and women. Males (n = 7; mean (± SD) age, 22.1 ± 1.5 y) and females (n = 8; mean (± SD) 24.5 ± 4.9 y) performed an incremental cycle test to determine maximal oxygen consumption ([Formula: see

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Nurbaeva, K., T. Reshetnyak, F. Cheldieva, M. Cherkasova, E. Samarkina, and A. Lila. "AB0116 NEW INFLAMMATORY MARKERS IN SYSTEMIC LUPUS ERYTHEMATOSUS AND ANTIPHOSPHOLIPID SYNDROME." Annals of the Rheumatic Diseases 81, Suppl 1 (2022): 1188.1–1189. http://dx.doi.org/10.1136/annrheumdis-2022-eular.1331.

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BackgroundThromboinflammation is a pathological process that is associated with uncontrolled inflammation, leading to hypercoagulability and thrombotic complications. Systemic lupus erythematosus (SLE) and antiphospholipid syndrome (APS) are prototypical chronic thromboinflammatory diseases. Neutrophils are important cells in the development of systemic inflammation and thrombosis. Neutrophil reactivity (NEUT-RI), neutrophil granularity (NEUT-GI), immature granulocytes (IG), and neutrophil-to-lymphocyte ratio (NLR) are considered as inflammatory markers.ObjectivesTo determine the role of param

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Nardi, P., V. Labriola, P. Calogera, et al. "DIFFERENT INTRAOPERATIVE TRANSIT TIME FLOW MEASUREMENT DOES NOT AFFECT EARLY OUTCOME IN FEMALE AND MALE GENDER AFTER CABG." European Heart Journal Supplements 26, Supplement_2 (2024): ii63. http://dx.doi.org/10.1093/eurheartjsupp/suae036.143.

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Abstract Background Intraoperative transit time flow measurement (TTFM) of left internal thoracic (L–ITA) and saphenous vein (SV) grafts (SVG) can improve graft patency and, consequently, clinical outcome in patients undergoing coronary artery bypass grafting (CABG). We have investigate if there were differences in female and male gender on TTFM –flow (mL/min) and pulsatility index (PI)– measured at the weaning form cardio–pulmonary bypass after CABG and early results. We started to use TTFM on September 2022. Methods Between September 2022 and September 2023, TTFM was performed in 101 patient

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Flores, Christian, Carlos Mariscal, Alfredo Celis, et al. "Treatment Outcomes and Prognostic Factors in Mexican Patients with Endometrial Carcinoma with Emphasis on Patients Receiving Radiotherapy after Surgery: An Institutional Perspective." ISRN Oncology 2012 (May 17, 2012): 1–10. http://dx.doi.org/10.5402/2012/178051.

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Aim. To analyze the clinical characteristics and treatment outcomes in patients with endometrial carcinoma treated in a Latin American institute with emphasis in patients receiving adjuvant radiotherapy. Methods. A total of 412 patients with endometrial carcinoma admitted to our hospital between 1998 and 2008 were evaluated, retrospectively. The mean age was 55 years (28–87). Two hundred seventy patients received RT following surgery. Stage distribution was as follows: 221 patients (54%) stage I, 86 patients (21%) stage II, and 103 patients (24.5%) stage III and 2 patients (0.5%) stage IVA. Re

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Leung, John, Long Hang, Arthur Blum, Tommy Setiawan, Karynn Stoyanoff, and Joel Weinstock. "Helminths abrogate antigen-specific gut inflammation in a novel murine model of non-IgE mediated food hypersensitivity (97.13)." Journal of Immunology 184, no. 1_Supplement (2010): 97.13. http://dx.doi.org/10.4049/jimmunol.184.supp.97.13.

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Abstract Non-IgE mediated (NIE) food hypersensitivities (FH) affect 2 million Americans. Helminths protect from IgE-mediated FH. Their effect on NIEFH has not been studied. We developed a murine model of NIEFH featuring severe antigen-specific enterocolitis with Th1/Th17 polarization. We used this unique model to test if helminths protect against NIEFH. METHODS: Rag1-/- mice, IL10-/- T cells and ovalbumin (OVA)-specific, TCR transgenic OT2 T cells were used to develop the NIEFH model. 6-wk-old Rag mice were reconstituted with IL10-/- and OT2 T cells. To determine if helminths protect, mice wer

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Aguiar, Bernardo Almeida, Marcelo de Morais Vitoriano, Luiz Carlos Trévia Morais Correa Viana, et al. "Estudo ex vivo da elevação do pH em superfície radicular externa após agitação ultrassônica de diferentes pastas de hidróxido de cálcio." Dental Press Endodontics 10.14436/2358-2545.11, no. 2 (2021): 38–43. http://dx.doi.org/10.14436/2358-2545.11.2.038-043.oar.

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Objetivo: O presente estudo teve por objetivo avaliar, ex vivo, a capacidade de elevação do pH da superfície radicular externa de diferentes pastas de hidróxido de cálcio (HC) utilizadas como medicação intracanal, além da influência da ativação ultrassônica (AUS) durante aplicação no interior do canal radicular. Métodos: Foram utilizados 100 incisivos humanos superiores unirradiculares, que tiveram os canais radiculares modelados e divididos aleatoriamente em seis grupos experimentais (n=15), de acordo com a pasta de HC, tendo como variáveis as medicações utilizadas e a ativação da pasta com A

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Schwarz, Klaus, and Reiner Creutzburg. "Design of Professional Laboratory Exercises for Effective State-of-the-Art OSINT Investigation Tools - Part 1: RiskIQ Passive-Total." Electronic Imaging 2021, no. 3 (2021): 43–1. http://dx.doi.org/10.2352/issn.2470-1173.2021.3.mobmu-043.

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Open-source technologies (OSINT) are becoming increasingly popular with investigative and government agencies, intelligence services, media companies, and corporations. These OSINT technologies use sophisticated techniques and special tools to analyze the continually growing sources of information efficiently. There is a great need for professional training and further education in this field worldwide. After having already presented the overall structure of a professional training concept in this field in a previous paper [25], this series of articles offers individual further training module

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Ossenkoppele, Gert J., Georg Stussi, Johan Maertens, et al. "Addition of bevacizumab to chemotherapy in acute myeloid leukemia at older age: a randomized phase 2 trial of the Dutch-Belgian Cooperative Trial Group for Hemato-Oncology (HOVON) and the Swiss Group for Clinical Cancer Research (SAKK)." Blood 120, no. 24 (2012): 4706–11. http://dx.doi.org/10.1182/blood-2012-04-420596.

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Abstract An urgent need for new treatment modalities is emerging in elderly patients with acute myeloid leukemia (AML). We hypothesized that targeting VEGF might furnish an effective treatment modality in this population. Elderly patients with AML were randomly assigned in this phase 2 study (n = 171) to receive standard chemotherapy (3 + 7) with or without bevacizumab at a dose of 10 mg/kg intravenously at days 1 and 15. In the second cycle, patients received cytarabine 1000 mg/m2 twice daily on days 1-6 with or without bevacizumab. The complete remission rates in the 2 arms were not differen

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Yong, Su, Liu Suping, Zhang Peng, Lin Dong, and Wei Qing. "The effects of vitamin C supplementation in the critically ill patients outcomes: A systematic review and meta-analysis of randomized controlled trials." Medicine 103, no. 12 (2024): e37420. http://dx.doi.org/10.1097/md.0000000000037420.

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Background: Vitamin C has significant anti-inflammatory effects and is particularly important for critically ill patients. However due to inconsistent research findings in critically ill patients in meta-analysis. Therefore, the primary objective of this meta-analysis is to investigate the effects of isolated intravenous supplementation of vitamin C in adults with critical illness by comprehensively incorporating articles from randomized controlled trials. Methods: Articles included searching through PubMed, Embase, Medline, Cochrane Library, and Web of Science up to April 28, 2023, for articl

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McBain, Catherine, Ingo K. Mellinghoff, Martin J. van den Bent, et al. "INDIGO: A GLOBAL, RANDOMIZED, DOUBLE-BLINDED, PHASE 3 STUDY OF VORASIDENIB VERSUS PLACEBO IN PATIENTS WITH RESIDUAL OR RECURRENT GRADE 2 GLIOMA WITH AN IDH1/2 MUTATION." Neuro-Oncology 25, Supplement_3 (2023): iii6. http://dx.doi.org/10.1093/neuonc/noad147.025.

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Abstract AIMS Current treatments grade 2 gliomas are not curative and can be associated with short- and long-term toxicities. Vorasidenib (VOR), an oral, brain-penetrant, dual inhibitor of mutant (m)IDH1/2 enzymes, has shown a tolerable safety profile and preliminary clinical activity in phase 1 studies. METHOD In the phase 3 INDIGO study (NCT04164901), patients (pts) were randomized 1:1 to receive VOR 40 mg daily or placebo (PBO) daily in 28-day cycles. Patients were stratified by 1p19q status and baseline tumor size. Key eligibility criteria included: age ≥12; KPS &gt;80; residual or rec

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Navrkalova, Veronika, Jitka Malcikova, Barbara Kantorova, et al. "SF3B1 Mutations Frequently Occur With Both ATM Mutations and TP53 Mutations In CLL Patients." Blood 122, no. 21 (2013): 2868. http://dx.doi.org/10.1182/blood.v122.21.2868.2868.

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Abstract Abnormalities of TP53 and ATM genes are well established adverse prognostic markers in CLL. Mutations in splicing factor SF3B1 have recently been described as recurrent and predominantly subclonal aberration. Previous studies inconsistently suggested mutual exclusivity or partial overlap with TP53 mutations. Concerning ATM defects, the association between SF3B1 mutations and del(11q) was reported, but relation to ATM mutations remains unclear. The aims were: (a) to assess association between SF3B1 mutations and the most adverse classic genetic lesions represented by TP53 mutations and

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AH SHITTA, AH SHITTA, ED DUNG ED DUNG, SD PETER SD PETER, et al. "Spectrum Of Hernias Among Children on The Plateau." Journal of Medical and Dental Science Research 12, no. 6 (2025): 55–60. https://doi.org/10.35629/076x-12065560.

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Introduction: Hernia is one of the commonest congenital presentations to paediatric surgical clinics worldwide. Most literatures on paediatric hernias discuss mainly inguinal hernias as paediatric hernias, however just like in adults, the spectrum of paediatric hernias spans beyond the groin, to include the entire abdominal wall hernias and internal hernias. Objective: This study aimed to describe the epidemiology of hernias in children on the plateau, highlighting its prevalence, management and outcomes. Methods:This was a retrospective study where we analysed the medical records of children

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