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Journal articles on the topic '338.476 7'

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Published: 4 June 2021

Last updated: 7 February 2022

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1

Glintborg, Bente, Inge J. Sørensen, Mikkel Østergaard, et al. "Ankylosing Spondylitis versus Nonradiographic Axial Spondyloarthritis: Comparison of Tumor Necrosis Factor Inhibitor Effectiveness and Effect of HLA-B27 Status. An Observational Cohort Study from the Nationwide DANBIO Registry." Journal of Rheumatology 44, no. 1 (2016): 59–69. http://dx.doi.org/10.3899/jrheum.160958.

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Objective.To compare baseline disease activity and treatment effectiveness in biologic-naive patients with nonradiographic axial spondyloarthritis (nr-axSpA) and ankylosing spondylitis (AS) who initiate tumor necrosis factor inhibitor (TNFi) treatment and to study the role of potential confounders (e.g., HLA-B27 status).Methods.Observational cohort study based on prospectively registered data in the nationwide DANBIO registry. We used Kaplan-Meier plots, Cox, and logistic regression analyses to study the effect of diagnosis (nr-axSpA vs AS) and potential confounders (sex/age/start yr/HLA-B27/d

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Javle, Milind M., Daniel Catenacci, Apurva Jain, et al. "Precision medicine for gallbladder cancer using somatic copy number amplifications (SCNA) and DNA repair pathway gene alterations." Journal of Clinical Oncology 35, no. 15_suppl (2017): 4076. http://dx.doi.org/10.1200/jco.2017.35.15_suppl.4076.

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4076 Background: Gallbladder carcinoma (GBC) is commonly diagnosed at an advanced, unresectable disease stage and has a poor prognosis. Comprehensive genomic profiling (CGP) has a developing role in guiding systemic, precision anti-cancer therapy. Methods: We performed hybrid capture-based CGP on FFPE samples for 491 consecutive advanced GBCs. Mean coverage depth was >550X for up to 315 cancer-related genes plus 37 introns from 28 genes frequently rearranged in cancer. All 4 classes of genomic alterations (GA) were detected. Tumor mutational burden (TMB) was determined on up to 1.1 Mb of se

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Ayer, William A., and Julie S. Racok. "The metabolites of Talaromycesflavus: Part 1. Metabolites of the organic extracts." Canadian Journal of Chemistry 68, no. 11 (1990): 2085–94. http://dx.doi.org/10.1139/v90-318.

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The soil fungus Talaromycesflavus (Klöcker) Stolk and Samson is an effective biological control for Verticillium wilt of eggplant (Solanummelongena L.), a disease caused by the fungus Verticilliumdahliae Kleb. The organic soluble metabolites produced when the fungus is grown in liquid still culture include D-glucono-1,4-lactone (1), 5-hydroxymethylfurfural (5), the previously unreported tetraketides, 4,6-dihydroxy-5-methylphthalide (3) and methyl 4-carboxy-5-hydroxyphthalaldehydate (8), a hexaketide, 7-hydroxy-2,5-dimethylchromone (6), and a metabolite believed to be 3-hydroxymethyl-6,8-dimeth

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Bi, Feng, Shukui Qin, Shanzhi Gu, et al. "Donafenib versus sorafenib as first-line therapy in advanced hepatocellular carcinoma: An open-label, randomized, multicenter phase II/III trial." Journal of Clinical Oncology 38, no. 15_suppl (2020): 4506. http://dx.doi.org/10.1200/jco.2020.38.15_suppl.4506.

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4506 Background: Sorafenib is still the standard first-line therapy for advanced hepatocellular carcinoma (HCC). Donafenib, a novel multikinase inhibitor, showed potential benefits in a previous phase Ib study in HCC. Methods: In this open-label, randomized phase II/III trial (ZGDH3), patients with unresectable or metastatic HCC, a Child-Pugh liver function score ≤ 7, and no prior systemic therapy were enrolled from 37 sites across China and randomized (1:1) to receive oral donafenib (0.2 g) or sorafenib (0.4 g) twice daily until intolerable toxicity or disease progression. The primary endpoin

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MacIntyre, M. M. J. "Book reviewsCare of the Cancer Patient. 2nd edit. By CapraL. G., pp. 476, 1986 (MacMillan, Basingstoke), £28.50 (hardback), £12.95 (paperback). ISBN 0–333–38615–9 (hbk), 0–333–38616–7 (pbk)." British Journal of Radiology 60, no. 720 (1987): 1196. http://dx.doi.org/10.1259/0007-1285-60-720-1196-b.

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Williams, J. A. Gareth. "Edited by Manfred Schlosser. Organometallics in synthesis: a manual. John Wiley & Sons, Chichester, 2002, 2nd edn, 1243 pp; price £95.00. ISBN 0-471-98416-7." Applied Organometallic Chemistry 16, no. 9 (2002): 556. http://dx.doi.org/10.1002/aoc.335.

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Rothwell, Geoffrey. "Book Reviews." Journal of Economic Literature 37, no. 1 (1999): 205–7. http://dx.doi.org/10.1257/jel.37.1.184.r16.

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Too Cheap to Meter: An Economic and Philosophical Analysis of the Nuclear Dream. By Steven Mark Cohn. Series in Radial and Social Political Thoery. Albany: State University of New York Press, 1997. Pp. xvii, 467. $21.95, paper. ISBN 0–7914–3389–7, cloth; 0–7914–3390–0, pbk. JEL 98–0621

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Kang, Jiyeon, and Jinkook Tak. "Development and validity of the communication competence scale of middle managers." Korean Journal of Industrial and Organizational Psychology 32, no. 4 (2019): 439–71. http://dx.doi.org/10.24230/kjiop.v32i4.439-471.

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This study was intended to develop the communication competence scale for middle manager in organizations and examine its validity. To develop the communication competence scale of middle managers, first, 632 items were extracted through literature review, expert interview and open surveys for middle managers. In the process of developing the items, it was found that there were differences in competencies between communication with superiors and communication with subordinates. Thus it was decided to develop two different scales for each of middle managers’ communication competencies with supe

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Santiso, Carlos. "Defusing democracy: central bank independence and the transition from authoritarian rule. Delia M. Boylan University of Michigan Press, Ann Arbor, 2001, xiv + 296pp, ISBN 0-472-11214-7." Public Administration and Development 25, no. 3 (2005): 269–70. http://dx.doi.org/10.1002/pad.330.

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Margaris, Basil, Emmanuel M. Scordilis, Jonathan P. Stewart, et al. "Hellenic Strong-Motion Database with Uniformly Assigned Source and Site Metadata for the Period 1972–2015." Seismological Research Letters 92, no. 3 (2021): 2065–80. http://dx.doi.org/10.1785/0220190337.

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Abstract We present a Hellenic database of intensity measures from uniformly processed strong ground motion recordings, together with metadata on earthquake source attributes and recording site conditions. The database consists of information from 471 earthquakes between 1973 and 2015 that produced 2993 usable recordings from 333 sites. A key element of this work is a unified presentation of data from two major data providers that operate in Greece (Institute of Engineering Seismology and Earthquake Engineering and the Institute of Geodynamics, National Observatory of Athens) along with a univ

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GHENCIU, IOANA, та PAUL LEWIS. "UNCONDITIONAL CONVERGENCE IN THE STRONG OPERATOR TOPOLOGY AND ℓ∞". Glasgow Mathematical Journal 53, № 3 (2011): 583–98. http://dx.doi.org/10.1017/s0017089511000152.

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AbstractIn this paper we study non-complemented spaces of operators and the embeddability of ℓ∞ in the spaces of operators L(X, Y), K(X, Y) and Kw*(X*, Y). Results of Bator and Lewis [2, 3] (Bull. Pol. Acad. Sci. Math.50(4) (2002), 413–416; Bull. Pol. Acad. Sci. Math.549(1) (2006), 63–73), Emmanuele [8–10] (J. Funct. Anal.99 (1991), 125–130; Math. Proc. Camb. Phil. Soc.111 (1992), 331–335; Atti. Sem. Mat. Fis. Univ. Modena42(1) (1994), 123–133), Feder [11] (Canad. Math. Bull.25 (1982), 78–81) and Kalton [16] (Math. Ann.208 (1974), 267–278), are generalised. A vector measure result is used to s

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Censi, Simona, Susi Barollo, Elisabetta Grespan, et al. "Prognostic significance of TERT promoter and BRAF mutations in TIR-4 and TIR-5 thyroid cytology." European Journal of Endocrinology 181, no. 1 (2019): 1–11. http://dx.doi.org/10.1530/eje-19-0073.

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ObjectiveFollicular-derived thyroid cancers generally have a good prognosis, but in a minority of cases, they have an aggressive behavior and develop distant metastases, with an increase in the associated mortality. None of the prognostic markers currently available prior to surgery can identify such cases.MethodsTERTpromoter andBRAFgene mutations were examined in a series of 436 consecutive TIR-4 and TIR-5 nodes referred for surgery. Follow-up (median: 59 months, range: 7–293 months) was available for 384/423 patients with malignant nodes.ResultsTERTpromoter andBRAFmutations were detected in

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Cook, Elizabeth, Mildred Ramirez, and Mark Turrentine. "Time Has Come for Routine Penicillin Allergy Testing in Obstetrics." American Journal of Perinatology Reports 10, no. 01 (2020): e15-e19. http://dx.doi.org/10.1055/s-0039-3401801.

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Abstract Objective This study evaluates penicillin allergy during pregnancy to estimate the proportion that could benefit from penicillin allergy testing. Study Design Retrospective cohort study of women with penicillin allergy that delivered from January 1, 2018 to December 31, 2018. Results Among 6,321 deliveries, 446 (7%) were identified with penicillin allergy. Nine percent (41/446) had no documentation of allergy severity. Allergies associated with intolerance, low, moderate, or high risk of anaphylaxis were reported in 6% (25/446), 40% (177/446), 32% (142/446), and 14% (61/446), respecti

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Slenders, Jos P. L., Daan P. J. Verberne, Johanna M. A. Visser-Meily, Renske M. Van den Berg-Vos, Vincent I. H. Kwa, and Caroline M. van Heugten. "Early cognitive and emotional outcome after stroke is independent of discharge destination." Journal of Neurology 267, no. 11 (2020): 3354–61. http://dx.doi.org/10.1007/s00415-020-09999-7.

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Abstract Background and purpose Cognitive and emotional problems occur frequently after stroke. Patients with minor stroke are more likely to be discharged home. This paper compares early cognitive and emotional outcomes in patients discharged home after stroke versus patients discharged to inpatient rehabilitation, and examines the effect of cognitive and emotional outcomes on long-term participation. Methods In this multicenter prospective cohort study, patients with stroke were assessed at two months with the Hospital Anxiety and Depression Scale (HADS), the Checklist for Cognitive and Emot

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Sarmiento, Mauricio J., and Jeff S. Kuehny. "Efficacy of Paclobutrazol and Gibberellin4+7 on Growth and Flowering of Three Curcuma Species." HortTechnology 13, no. 3 (2003): 493–96. http://dx.doi.org/10.21273/horttech.13.3.0493.

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Rhizomes of Curcuma alismatifolia Roxb. `Chiang Mai Pink', C. gracillima Roxb. `Violet', and C. thorelii Roxb. were soaked in gibberellin (GA4+7) at 0, 200, 400, or 600 mg·L-1 (ppm) and planted into 15.2-cm-diameter (6 inches) containers. The plants were grown in a greenhouse at 30 °C day/23 °C night (86.0/73.4 °F) temperatures. When shoot height was 10 cm (3.9 inches), the plants were drenched with 118 mL (3.9 fl oz) of paclobutrazol at 0, 2, 3, or 4 mg a.i. per 15.2-cm-diameter container. Gibberellin4+7 delayed shoot emergence and fl owering but did not affect the fl ower number. Paclobutraz

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Akyol, Okan, and Kutsal Gamsiz. "Age and growth of adult gilthead seabream (Sparus aurata L.) in the Aegean Sea." Journal of the Marine Biological Association of the United Kingdom 91, no. 6 (2010): 1255–59. http://dx.doi.org/10.1017/s0025315410001220.

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Age and growth of adult gilthead seabream, Sparus aurata were determined from 332 specimens (total N = 476), collected from purse-seiners, in the south-eastern Aegean Sea from November 2006 to January 2007. The fork length and body wet weight ranged from 26.5 to 51.5 cm (mean: 36.6 ± 0.18) and from 375 to 2600 g (mean: 1009.2 ± 14.16), respectively. Age groups were varied between 2 and 7. Growth parameters were estimated as L∞ = 64.97 ± 12.93 cm, K = 0.14 ± 0.07 year−1, t0 = −2.47 ± 1.09 year−1, and index of phi-prime was Φ′ = 2.772 ± 0.51. The length–weight relationship equation of all fish w

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Rodriguez-García, S. C., C. Sánchez-Piedra, R. Castellanos-Moreira, et al. "POS0610 EPIDEMIOLOGIC PROFILE AND CHANNELING TO TREATMENT IN RHEUMATOID ARTHRITIS PATIENTS TREATED WITH ABATACEPT OVER THE LAST 5 YEARS: DATA FROM THE SPANISH REGISTER BIOBADASER 3.0." Annals of the Rheumatic Diseases 80, Suppl 1 (2021): 542.1–542. http://dx.doi.org/10.1136/annrheumdis-2021-eular.1534.

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Background:Abatacept (ABA) is a selective T-cell co-stimulatory modulator. After its approval, changes in therapeutic recommendations, the arrival of new drugs (e.g., biosimilars or Janus kinase inhibitors) and growing focus on comprehensive patient care may have changed prescription patterns, channeling ABA use towards specific patient subtypes. To date, studies analyzing these aspects in clinical practice settings are scarce.Objectives:We aimed to evaluate the epidemiological profile of ABA users and compare it to other DMARD groups included in the register.Methods:We performed an observatio

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Rivers, Angela, Ramasamy Jagadeeswaran, and Donald Lavelle. "Potential role of LSD1 inhibitors in the treatment of sickle cell disease: a review of preclinical animal model data." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 315, no. 4 (2018): R840—R847. http://dx.doi.org/10.1152/ajpregu.00440.2017.

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Sickle cell disease (SCD) is caused by a mutation of the β-globin gene (Ingram VM. Nature 180: 326–328, 1957), which triggers the polymerization of deoxygenated sickle hemoglobin (HbS). Approximately 100,000 SCD patients in the United States and millions worldwide (Piel FB, et al. PLoS Med 10: e1001484, 2013) suffer from chronic hemolytic anemia, painful crises, multisystem organ damage, and reduced life expectancy (Rees DC, et al. Lancet 376: 2018–2031, 2010; Serjeant GR. Cold Spring Harb Perspect Med 3: a011783, 2013). Hematopoietic stem cell transplantation can be curative, but the majority

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Thapa, Amit, Bidur KC, Bikram Shakya, and Rupesh Chakradhar. "WeMPiC protocol to prevent Deep Venous Thrombosis in patients with neurosurgical diseases." Nepal Journal of Neuroscience 17, no. 1 (2020): 10–20. http://dx.doi.org/10.3126/njn.v17i1.28337.

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Background: Deep Venous Thrombosis is a common yet difficult problem to prevent in neurosurgical patients. Recent trials did not find sufficient evidence to support use of graduated compression stockings, however we believe, this inefficiency may be due to the method of application which needs to be modified. We have been following a patient specific mechanical prophylaxis protocol, nicknamed WeMPiC. This study aims to evaluate the effectiveness of WeMPiC protocol. Methods: An observational cohort study was performed including consecutive patients admitted to neurosurgical ICU who were b

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Khodzhieva, M. V., V. A. Skvortsova, T. E. Borovik, et al. "Evaluating the Physical Development of Early Age Schoolchildren (7–10 Years): Cohort Study Results." Pediatric pharmacology 13, no. 4 (2016): 362–66. http://dx.doi.org/10.15690/pf.v13i4.1608.

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Background:Misbalance between energy intake and consumption is considered the main reason of obesity. However, over the recent years there has been a lot of emerging data concerning early origins of obesity that forms during intrauterine development and/or early age periods.Objective:Our aim was to study how physically developed are the children of early school ages.Methods:The study included children aged 7 to 10 years. Their physical development was assessed with the WHO AnthroPlus (2009) software.Results:652 children were examined. Of them, balanced development was found in: according to th

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Page, Mollie C., Priscila A. Cassaglia, and Virginia L. Brooks. "GABA in the paraventricular nucleus tonically suppresses baroreflex function: alterations during pregnancy." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 300, no. 6 (2011): R1452—R1458. http://dx.doi.org/10.1152/ajpregu.00736.2010.

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It is well established that GABAergic inputs to the paraventricular nucleus of the hypothalamus (PVN) tonically suppress heart rate and the activity of several sympathetic nerves. However, whether GABA similarly inhibits PVN control of baroreflex function has not been previously investigated. To test this hypothesis, it was determined whether microinjection of the GABAA antagonist, bicuculline, into the PVN enhances the baroreflex in anesthetized female virgin rats. In addition, because GABAergic inhibition of PVN preautonomic neurons is decreased during pregnancy, it was also determined wheth

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Scott-Bottoms, Stephen. "Kimberly Jannarone, ed. Vanguard Performance Beyond Left and Right Ann Arbor: University of Michigan Press, 2015. 334 p. $70. ISBN 978-0-472-11967-7." New Theatre Quarterly 34, no. 4 (2018): 398. http://dx.doi.org/10.1017/s0266464x18000519.

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Maataoui, Naouale, Céline Langendorf, Fatou Berthe, et al. "Increased risk of acquisition and transmission of ESBL-producing Enterobacteriaceae in malnourished children exposed to amoxicillin." Journal of Antimicrobial Chemotherapy 75, no. 3 (2019): 709–17. http://dx.doi.org/10.1093/jac/dkz487.

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Abstract Objectives Routine amoxicillin for children with uncomplicated severe acute malnutrition raises concerns of increasing antibiotic resistance. We performed an ancillary study nested within a double-blind, placebo-controlled trial in Niger testing the role of routine 7 day amoxicillin therapy in nutritional recovery of children 6 to 59 months of age with uncomplicated severe acute malnutrition. Methods We screened 472 children for rectal carriage of ESBL-producing Enterobacteriaceae (ESBL-E) as well as their household siblings under 5 years old, at baseline and Week 1 (W1) and Week 4 (W

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Ertenli, A. İ., U. Kalyoncu, O. Karadag, et al. "AB0200 TRENDS IN THE CHOICE OF FIRST BIOLOGIC AND TARGETED SYNTHETIC DMARD IN RHEUMATOID ARTHRITIS PATIENTS: 20-YEARS JOURNEY OF HUR-BIO REAL-LIFE REGISTRY." Annals of the Rheumatic Diseases 80, Suppl 1 (2021): 1124.2–1124. http://dx.doi.org/10.1136/annrheumdis-2021-eular.693.

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Background:In the last 20 years, there have been extraordinary improvements and practice-changing developments in the management of rheumatoid arthritis (RA). Exploring the pathogenetic mechanisms first enabled clinicians to use anti-tumor necrosis factor (TNF) alpha agents, then drugs targeting different molecules. Parallel to these developments, treatment guidelines have been changed accordingly. Meanwhile, how these developments have been reflected into the real-word practice is a question of interest.Objectives:In this study, we aimed to explore the first biologic agent trends of our 20-ye

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Lanzillotta, M., E. Della Torre, C. Campochiaro, G. Mancuso, and L. Dagna. "SAT0528 CLINICAL PHENOTYPES OF IGG4-RELATED DISEASE REFLECT DIFFERENCES IN EPIDEMIOLOGICAL FEATURES, SEROLOGICAL FINDINGS, AND PROGNOSTIC OUTCOMES." Annals of the Rheumatic Diseases 79, Suppl 1 (2020): 1221.1–1222. http://dx.doi.org/10.1136/annrheumdis-2020-eular.1438.

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Background:Four clinical phenotypes of IgG4-Related Disease (IgG4-RD) have been recently identified by Latent Class Analysis (LCA) - Pancreato/biliary (Group 1); Retroperitoneum/Aortitis (Group 2); Head-and-neck limited (Group 3); Mickulicz/Systemic (Group 4) - but the relevance of this classification for patient management remains unknown (1,2).Objectives:We aimed to assess whether clinical judgment can replicate LCA classification and to evaluate potential differences in epidemiological features, serological findings, and disease outcomes between disease phenotypes.Methods:The study included

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Facciorusso, Antonio, Marco Bertini, Michele Bertoni, et al. "Effectiveness of hemostatic powders in lower gastrointestinal bleeding: a systematic review and meta-analysis." Endoscopy International Open 09, no. 08 (2021): E1283—E1290. http://dx.doi.org/10.1055/a-1495-4764.

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Abstract Background and study aims There is limited evidence on the effectiveness of hemostatic powders in the management of lower gastrointestinal bleeding (LGIB). We aimed to provide a pooled estimate of their effectiveness and safety based on the current literature. Patients and methods Literature review was based on computerized bibliographic search of the main databases through to December 2020. Immediate hemostasis, rebleeding rate, adverse events, and mortality were the outcomes of the analysis. Pooled effects were calculated using a random-effects model. Results A total of 9 studies wi

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Biktimirov, Rifhat, Zul'fira Sharipkulova, and Asiya Nizaeva. "Agroecological assessment of Sudan grass cultivars and new hybrid populations of Bashkir selection." Agrarian Bulletin of the 201, no. 10 (2020): 2–7. http://dx.doi.org/10.32417/1997-4868-2020-201-10-2-7.

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Abstract. The purpose of research is to evaluate Sudan grass cultivars in terms of phenotypic plasticity and yield stability in changing environmental conditions. Research methods. The article presents the data of the research conducted in conditions of the Cis-Ural steppe of the Bashkortostan Republic in 2016–2019. 12 Sudan grass cultivars and hybrid populations, selected in the Bashkir Research Institute of Agriculture, being of varied ripeness, were studied for yielding capacity, stability, and plasticity. Weather conditions in the years of research on temperature and water regimes were dif

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Walz, Lars, Gian M. Salzmann, Thomas Fabbro, Stefan Eichhorn, and Andreas B. Imhoff. "The Anatomic Reconstruction of Acromioclavicular Joint Dislocations Using 2 TightRope Devices." American Journal of Sports Medicine 36, no. 12 (2008): 2398–406. http://dx.doi.org/10.1177/0363546508322524.

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Background For the reconstruction of acromioclavicular (AC) joint separation, several operative procedures have been described; however, the anatomic reconstruction of both coracoclavicular ligaments has rarely been reported. Purpose The aim of this biomechanical study is to describe a new procedure for anatomic reconstruction of the AC joint. Study Design Controlled laboratory study. Materials and Methods Forty fresh-frozen cadaveric shoulders were tested. Cyclic loading and a load-to-failure protocol was performed in vertical (native, n = 10; reconstructed, n = 10) and anterior directions (n

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Necchi, Andrea, Luigi Mariani, Salvatore Lo Vullo, et al. "Impact of number of cycles of platinum-based first-line chemotherapy for advanced urothelial carcinoma." Journal of Clinical Oncology 36, no. 6_suppl (2018): 426. http://dx.doi.org/10.1200/jco.2018.36.6_suppl.426.

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426 Background: 6 cycles of platinum-based chemotherapy (CT) are conventionally targeted to treat locally advanced unresectable or metastatic urothelial carcinoma (UC). However, cisplatin is associated with significant cumulative toxicities, which render it challenging to deliver 6 cycles. Since this issue has not been investigated prospectively, we conducted a retrospective analysis. Methods: The Retrospective International Study of Invasive/Advanced Cancer of the Urothelium (RISC) database was used to conduct a retrospective analysis. The association of the number of cycles of platinum-based

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Chen, Hsing-Yin, and Wen-Shyan Sheu. "Reply to the comment on `Iodine effect on the relaxation pathway of photoexcited I−(H2O)n clusters' [Chem. Phys. L 335 (2001) 475]." Chemical Physics Letters 353, no. 5-6 (2002): 459–62. http://dx.doi.org/10.1016/s0009-2614(02)00047-7.

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Hausmann, Petra, Ralf Sussmann, Thomas Trickl, and Matthias Schneider. "A decadal time series of water vapor and D / H isotope ratios above Zugspitze: transport patterns to central Europe." Atmospheric Chemistry and Physics 17, no. 12 (2017): 7635–51. http://dx.doi.org/10.5194/acp-17-7635-2017.

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Abstract. We present vertical soundings (2005–2015) of tropospheric water vapor (H2O) and its D ∕ H isotope ratio (δD) derived from ground-based solar Fourier transform infrared (FTIR) measurements at Zugspitze (47° N, 11° E, 2964 m a.s.l.). Beside water vapor profiles with optimized vertical resolution (degrees of freedom for signal, DOFS, = 2.8), {H2O, δD} pairs with consistent vertical resolution (DOFS = 1.6 for H2O and δD) applied in this study. The integrated water vapor (IWV) trend of 2.4 [−5.8, 10.6] % decade−1 is statistically insignificant (95 % confidence interval). Under this caveat

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Wu, Jianhua, Mamas A. Mamas, Mohamed O. Mohamed, et al. "Place and causes of acute cardiovascular mortality during the COVID-19 pandemic." Heart 107, no. 2 (2020): 113–19. http://dx.doi.org/10.1136/heartjnl-2020-317912.

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ObjectiveTo describe the place and causes of acute cardiovascular death during the COVID-19 pandemic.MethodsRetrospective cohort of adult (age ≥18 years) acute cardiovascular deaths (n=5 87 225) in England and Wales, from 1 January 2014 to 30 June 2020. The exposure was the COVID-19 pandemic (from onset of the first COVID-19 death in England, 2 March 2020). The main outcome was acute cardiovascular events directly contributing to death.ResultsAfter 2 March 2020, there were 28 969 acute cardiovascular deaths of which 5.1% related to COVID-19, and an excess acute cardiovascular mortality of 2085

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Offidani, Massimo, Laura Corvatta, Sara Bringhen, et al. "Infection Complications in 476 Patients with Newly Diagnosed Multiple Myeloma Treated with Lenalidomide or Bortezomib Combinations." Blood 126, no. 23 (2015): 5365. http://dx.doi.org/10.1182/blood.v126.23.5365.5365.

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Abstract Introduction. Multiple myeloma (MM) represents a population with an increased risk of developing infection up to 10-fold if compared with controls. Moreover, patients treated with new-drugs are at higher risk of infections compared with those treated previously (Blimark C. et al. Haematologica 2015). Grade 3-4 non-hematological toxicity, particularly cardiac and infection complications, are associated with shorter OS in patients with MM (Bringhen S. et al. Haematologica 2013) whereas thrombosis did not. Anyway, guidelines to prevent thrombosis are available but there are not as regard

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Reddy, Uma, Chun-Chih Huang, Rita Driggers, Helain Landy, Katherine Grantz, and Jasbir Singh. "Racial/Ethnic Differences in Labor Induction in a Contemporary US Cohort: A Retrospective Cohort Study." American Journal of Perinatology 35, no. 04 (2017): 361–68. http://dx.doi.org/10.1055/s-0037-1607285.

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Objective To examine labor induction by race/ethnicity and factors associated with disparity in induction. Study Design This is a retrospective cohort study of 143,634 women eligible for induction ≥24 weeks' gestation from 12 clinical centers (2002–2008). Rates of labor induction for each racial/ethnic group were calculated and stratified by gestational age intervals: early preterm (240/7–336/7), late preterm (340/7–366/7), and term (370/7–416/7 weeks). Multivariable logistic regression examined the association between maternal race/ethnicity and induction controlling for maternal characterist

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Gritti, Giuseppe, Augusto B. Federici, Agostino Cortelezzi, et al. "Circulating Versus Progenitor Endothelial Cells Levels Are Abnormal in Patients with Different Types of Von Willebrand Disease and Correlate with Markers of Angiogenesis." Blood 112, no. 11 (2008): 5457. http://dx.doi.org/10.1182/blood.v112.11.5457.5457.

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Abstract Background:Von Willebrand disease (VWD) is the most common inherited bleeding disorder that is characterized by deficiency or abnormality of von Willebrand factor (VWF). VWF, synthesized by endothelium and magakaryocytes, circulates in plasma and is present in sub-endothelium and platelets: therefore it is an ideal marker for endothelial formation/damage and megakaryocytopoiesis. Circulating (CEC) and progenitor (EPC) endothelial cells have been also proposed as markers of bone marrow-derived angiogenesis. Aims of the study: to evaluate the association of CEC/EPC with cellular and cir

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Lebedeva, Nadezhda O., Olga K. Vikulova, Alexei G. Nikitin, Minara Sh Shamkhalova, Marina V. Shestakova, and Ivan I. Dedov. "Pharmacogenetics of statin therapy and the endothelial function parameters in patients with type 2 diabetes mellitus." Diabetes mellitus 19, no. 3 (2016): 204–11. http://dx.doi.org/10.14341/dm200342-7.

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Aim. To investigate the association of variation in lipid-lowering response and endothelial function (EF) parameters after atorvastatin therapy in patients with type 2 diabetes mellitus (T2DM) with genetic markers of atherosclerosis.Methods. We included 97 patients with T2DM who were prescribed atorvastatin. Fasting lipid profiles and EF parameters were assessed before and after 12 months of statin therapy. For EF evaluation, we performed pulse-wave analysis during reactive hyperaemia. The genotypes for polymorphic markers were identified by real-time polymerase chain reaction with TaqMan prob

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Bucur, Maria, Alexandra Ghit, Ayşe Durakbaşa, et al. "Book Reviews." Aspasia 14, no. 1 (2020): 160–209. http://dx.doi.org/10.3167/asp.2020.140113.

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Cristina A. Bejan, Intellectuals and Fascism in Interwar Romania: The Criterion Association, Cham, Switzer land: Palgrave, 2019, 323 pp., €74.89 (hardback), ISBN 978-3-030-20164-7.Chiara Bonfiglioli, Women and Industry in the Balkans: The Rise and Fall of the Yugoslav Textile Sector, London: I. B. Tauris, 2020, 232 pp., £85 (hardback), ISBN: 978-1-78533-598-3.Aslı Davaz, Eşitsiz kız kardeşlik, uluslararası ve Ortadoğu kadın hareketleri, 1935 Kongresi ve Türk Kadın Birliği (Unequal sisterhood, international and Middle Eastern women’s movements, 1935 Congress and the Turkish Women’s Union), İst

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Fan, Fu-Ren F. "Imaging of Surfaces and Interfaces Edited by Jacek Lipkowski (University of Guelph) and Philip N. Ross (National Institutes of Health). J. Wiley & Sons: New York. 1999. 338 pp. $125.00. ISBN 0-471-24672-7." Journal of the American Chemical Society 122, no. 7 (2000): 1564. http://dx.doi.org/10.1021/ja995760s.

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Nusrat, Maliha, Jason Roszik, Riham Katkhuda, et al. "Association of PIK3CA mutations (mut) with immune engagement and clinical benefit from immunotherapy in microsatellite stable (MSS) colorectal cancer (CRC) patients (pts)." Journal of Clinical Oncology 37, no. 15_suppl (2019): 3604. http://dx.doi.org/10.1200/jco.2019.37.15_suppl.3604.

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3604 Background: PI3K pathway alterations, PIK3CA mut or PTEN loss, are known to modulate anti-tumor immune microenvironment. MSS CRC pts respond infrequently to immunotherapy, suggesting the presence of a rare MSS immunogenic subset. We investigated the immune repertoire and outcomes on immunotherapy trials in PIK3CA mut MSS CRC pts. Methods: Immune infiltrates and checkpoints were evaluated using quantitative immuno-histochemistry (IHC) on primary CRC. Mutations were assessed by next generation sequencing. PIK3CA mut neoepitopes and HLA allele affinities were predicted using NetMHC 4.0 Serve

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Hays, Michael D., David K. Ryan, and Stephen Pennell. "Multi-Wavelength Fluorescence-Quenching Model for Determination of Cu2+ Conditional Stability Constants and Ligand Concentrations of Fulvic Acid." Applied Spectroscopy 57, no. 4 (2003): 454–60. http://dx.doi.org/10.1366/00037020360626005.

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In this work, a multi-wavelength model (MWM) is developed. It uses fluorescence bands in the fulvic acid (FA) spectrum that quench upon binding of inorganic Cu2+ to FA. Quenching data at pH values of 5, 6, and 7 are placed in sets, containing fluorescence measures at select wavelengths versus added copper ( CM). Intensity data of wavelength set 1 are obtained from 25 nm constant offset synchronous fluorescence spectra (SyF), in which are observed distinct peaks (λex = 415 nm, λem = 440 nm; and λex = 471 nm, λem = 496 nm). Wavelength set 2 intensity data are obtained from the FA fluorescence ex

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Hawkins, Louise M. A., J. Michael Grappone, Courtney J. Sprain, et al. "Intensity of the Earth's magnetic field: Evidence for a Mid-Paleozoic dipole low." Proceedings of the National Academy of Sciences 118, no. 34 (2021): e2017342118. http://dx.doi.org/10.1073/pnas.2017342118.

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The Mesozoic Dipole Low (MDL) is a period, covering at least ∼80 My, of low dipole moment that ended at the start of the Cretaceous Normal Superchron. Recent studies of Devonian age Siberian localities identified similarly low field values a few tens of million years prior to the Permo-Carboniferous Reverse Superchron (PCRS). To constrain the length and timing of this potential dipole low, this study presents paleointensity estimates from Strathmore (∼411 to 416 Ma) and Kinghorn (∼332 Ma) lava flows, United Kingdom. Both localities have been studied for paleomagnetic poles (Q values of 6 to 7)

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Leow, Jeffrey J., Steven L. Chang, Toni K. Choueiri, and Joaquim Bellmunt. "Adjuvant chemotherapy for upper-tract urothelial carcinoma: A systematic review and meta-analysis of available studies." Journal of Clinical Oncology 32, no. 4_suppl (2014): 330. http://dx.doi.org/10.1200/jco.2014.32.4_suppl.330.

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330 Background: Upper-tract urothelial carcinoma (UTUC) accounts for less than 5% of all urothelial cancers. Adjuvant chemotherapy (AC) for UTUC may improve survival outcomes, but currently available evidence is limited. Methods: A comprehensive literature review was performed to identify all studies comparing AC with control for patients with UTUC. The search included the Medline, Embase, Cochrane Central Register of Controlled Trials databases, and abstracts from the American Society of Clinical Oncology meetings up to June 2013. An updated systematic review and meta-analysis was performed.

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WITTROCK, BJÖRN. "The Transformation of European Universities: Disciplines and Professions in England, Germany and Russia since 1870." Contemporary European History 13, no. 1 (2004): 101–16. http://dx.doi.org/10.1017/s0960777303001504.

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Dietrich Beyrau, ed., Im Dschungel der Macht. Intellektuelle Professionen unter Stalin und Hitler (Göttingen: Vandenhoeck & Ruprecht, 2000), 399 pp., €52.00 (hb.), ISBN 3-525-36244-7.Corine Defrance, Les alliés occidentaux et les universités allemandes, 1945–1949 (Paris: CNRS Éditions, 2000), 406 pp., €27.50, ISBN 2-271-05768-X.Ralph Jessen, Akademische Elite und kommunistische Diktatur. Die ostdeutsche Hochschullehrerschaft in der Ulbricht-Ära (Göttingen: Vandenhoeck & Ruprecht, 1999), 552 pp., €52.00, ISBN 3-525-35797-4.Brian Pullan with Michele Abendstern, A History of the Universit

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Berndt, Ernst R. "Book Review Inside the FDA: The Business and Politics Behind the Drugs We Take and the Food We Eat By Fran Hawthorne. 338 pp. Hoboken, N.J., John Wiley & Sons, 2005. $27.95. 0-471-61091-7." New England Journal of Medicine 353, no. 11 (2005): 1188. http://dx.doi.org/10.1056/nejmbkrev38565.

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Tewolde, H., M. C. Black, C. J. Fernandez, and A. M. Schubert. "Pod Yield Response of Two Runner Peanut Cultivars to Seeding Rate and Irrigation1." Peanut Science 29, no. 1 (2002): 1–8. http://dx.doi.org/10.3146/pnut.29.1.0001.

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Abstract Yield responses of two runner peanut cultivars, GK-7 and Southern Runner (SR), to reduced seeding rates and irrigation were evaluated in 1992 and 1993. The cultivars were planted in single rows per bed at 8,12, and 22 seed/m2 with a vacuum precision planter and irrigated with a line source irrigation system that delivered irrigation ranging from none to more than an apparent optimum. Total rainfall between planting and digging was 261 mm in 1992 and 338 mm in 1993. Most of the rainfall occurred early with substantial runoff. GK-7 produced as much as 5400 kg/ha pods and SR produced as

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Yadav, R., A. Yadav, and SS Oberoi. "Knowledge, Attitude and Aesthetic Perceptions about Dental Fluorosis among 12-15 Years Old Government School Children in Farukh Nagar, Haryana." Journal of Oral Health and Community Dentistry 8, no. 1 (2014): 1–5. http://dx.doi.org/10.5005/johcd-8-1-1.

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ABSTRACT Aims and objectives The present study was conducted to assess the opinions amongst schoolchildren about the appearance of dental fluorosis, to correlate the children's perceptions of dental fluorosis and to assess the impact of dental fluorosis on psychological health of the school children. Materials and methods A questionnaire was used for assessment of the Knowledge, Attitude and Aesthetic perceptions about Dental Fluorosis among 474, 12-15 years old school children studying in four government high schools of Farukh Nagar block, Gurgaon, Haryana. The study sample included 308 stude

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Schulz, T. F. "Book Review: AIDS and malignancies. Ed. by B.C. Golematis, V.T. De Vita, K.N. Syrigos and M. M. Konstantoulakis, John Wiley, Chichester, 1996, pp.338, ISBN 0-471-96714-9." Reviews in Medical Virology 7, no. 2 (1997): 123. http://dx.doi.org/10.1002/(sici)1099-1654(199707)7:2<123::aid-rmv194>3.0.co;2-n.

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O'Brien, Stephen G., Corinne Hedgley, Sarah Adams, et al. "Spirit 2: An NCRI Randomised Study Comparing Dasatinib with Imatinib in Patients with Newly Diagnosed CML." Blood 124, no. 21 (2014): 517. http://dx.doi.org/10.1182/blood.v124.21.517.517.

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Abstract Objective. SPIRIT 2 is the largest phase 3 prospective randomized open-label trial comparing imatinib 400mg with dasatinib 100mg daily: this is the first presentation of data comparing the two arms. Methods. 814 patients were recruited at 144 hospitals between August 2008 and March 2013. 812 started study medication (406 in each arm). The primary endpoint is event-free survival at 5 years. A key secondary endpoint is the rate of achievement of a BCR-ABL/ABL ratio of &lt;0.1%IS (major molecular response (MMR), 3 log reduction or MR3). Results. Discontinuations. With a median follow

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Bregoli-Russo, Mauda. "Kirkham Victoria, Fabulous Vernacular: Boccaccio's Filocolo and the Art of Medieval Fiction Ann Arbor: The University of Michigan Press, 2001. x + 318 pp. $47.50. ISBN: 0-472- 11164-7." Renaissance Quarterly 55, no. 4 (2002): 1380–82. http://dx.doi.org/10.2307/1262110.

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Xiang, Aizhai, Chen Ling, Wei Zhang, and Honggang Chen. "Effects of Rhizopus Nigricans Exopolysaccharide on Proliferation, Apoptosis, and Migration of Breast Cancer MCF-7 Cells and Akt Signaling Pathway." International Journal of Polymer Science 2021 (June 24, 2021): 1–6. http://dx.doi.org/10.1155/2021/5621984.

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Objective. To study the effect of Rhizopus nigricans exopolysaccharide EPS1-1 on the proliferation, apoptosis, and migration of breast cancer MCF-7 cells. Methods. Human breast cancer MCF-7 cells were cultured in vitro and treated with different concentrations of EPS1-1. The effect of EPS1-1 on cell proliferation was tested by the CCK-8 experiment, and the effect of EPS1-1 on cell apoptosis was determined by flow cytometry. And the scratch test was used to detect the impact of EPS1-1 on cell migration. Western blot then was used to measure the expression changes of related proteins in the Akt

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