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Journal articles on the topic '338.702 85'

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Published: 4 June 2021

Last updated: 8 February 2022

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1

Gardiner, G. E., E. O'Sullivan, J. Kelly, et al. "Comparative Survival Rates of Human-Derived ProbioticLactobacillus paracasei and L. salivariusStrains during Heat Treatment and Spray Drying." Applied and Environmental Microbiology 66, no. 6 (2000): 2605–12. http://dx.doi.org/10.1128/aem.66.6.2605-2612.2000.

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ABSTRACT Spray drying of skim milk was evaluated as a means of preservingLactobacillus paracasei NFBC 338 and Lactobacillus salivarius UCC 118, which are human-derived strains with probiotic potential. Our initial experiments revealed that NFBC 338 is considerably more heat resistant in 20% (wt/vol) skim milk than UCC 118 is; the comparable decimal reduction times were 11.1 and 1.1 min, respectively, at 59°C. An air outlet temperature of 80 to 85°C was optimal for spray drying; these conditions resulted in powders with moisture contents of 4.1 to 4.2% and viable counts of 3.2 × 109 CFU/g for N

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2

Walbank, Michael B. "Notes on Attic Decrees." Annual of the British School at Athens 85 (November 1990): 435–47. http://dx.doi.org/10.1017/s0068245400015781.

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Several fragments of 4th-century BC Athenian decree-inscriptions are discussed. Joins are made betweenIGii2. 13a and 68 andHesperia, 40, no. 3;IGii2. 257 and 300; 242 and 373; 407 andSEG32. 94;IGii2. 309 and 552; 530 and 590. Attributed to the same stele, but not joining, areIGii2. 139 and 289; 277 and 428; 540a andSEG24. 117;IGii2. 540b andHesperia, 21, no. 17;IGii2. 286 and 625; 414a and 403; 398a (+ 438) and 612; 484 and 558; 489 and 532; 495 and 709; 405 andHesperia, 4, no. 32. Other decrees discussed, mainly in light of the work of A.S. Henry on the formulae of Athenian decrees, areIGii2.

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3

Grønberg, Bjørn Henning, Tarje Onsoien Halvorsen, Øystein Fløtten, et al. "Randomized phase II trial comparing two schedules of thoracic radiotherapy (TRT) in limited disease small-cell lung cancer (LD SCLC)." Journal of Clinical Oncology 30, no. 15_suppl (2012): 7027. http://dx.doi.org/10.1200/jco.2012.30.15_suppl.7027.

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7027 Background: Concurrent chemotherapy and TRT is standard therapy for SCLC if all lesions can be included in a radiotherapy field (LD). Several schedules of TRT are used. One study showed that two fractions a day improved local control and overall survival (OS), but this schedule has not been compared to a commonly used 3 wks schedule. Methods: Eligible pts had LD SCLC and PS 0-2. Pleural fluid was accepted if negative cytology. Pts received 4 cycles of PE (cisplatin 75 mg/m2 IV day 1 and etoposide 100 mg/m2 IV day 1-3 q 3 wks) and were randomly assigned to 3 wks of 3D conformal TRT [A] 42

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Valezi, Antonio Carlos, and Vitor Hugo Soares Machado. "Emagrecimento e desempenho cardíaco." ABCD. Arquivos Brasileiros de Cirurgia Digestiva (São Paulo) 24, no. 2 (2011): 131–35. http://dx.doi.org/10.1590/s0102-67202011000200008.

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RACIONAL: As doenças cardiovasculares representam as complicações mais frequentemente associadas à obesidade. O emagrecimento determina diminuição da pressão arterial e melhora nos parâmetros dos lipídeos e glicose séricos. A perda de peso e sua manutenção reduzem os fatores de risco para doenças cardiovasculares, tornando, reversíveis as alterações cardíacas decorrentes da obesidade. OBJETIVO: Avaliar o efeito da perda de peso sobre a capacidade física e as alterações estruturais e funcionais do coração de obesos submetidos à procedimento cirúrgico bariátrico. MÉTODOS: Quarenta e três pacient

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Hansra, Damien Mikael, Amber Moran, Becky Slawik, et al. "Evaluation of pathologic and genomic characteristics in female breast cancer patients." Journal of Clinical Oncology 39, no. 15_suppl (2021): e13001-e13001. http://dx.doi.org/10.1200/jco.2021.39.15_suppl.e13001.

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e13001 Background: The genomic landscape of female breast cancer is rapidly evolving partially owing to advancements in next generation sequencing (NGS). Here we report the genomic characteristics of female breast cancer patients with locally recurrent inoperable and metastatic disease. Methods: IRB approval was obtained for a retrospective analysis of archived pathology on patients treated at Cancer Treatment Centers of America. Comprehensive genomic profiling of tumors was derived from Foundation One (F1) and Guardant 360 NGS. Clinical information was derived from retrospective chart review.

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Marquette, KA, DD Pittman, and RJ Kaufman. "The factor V B-domain provides two functions to facilitate thrombin cleavage and release of the light chain." Blood 86, no. 8 (1995): 3026–34. http://dx.doi.org/10.1182/blood.v86.8.3026.bloodjournal8683026.

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Blood coagulation factors V and VIII are homologous proteins that have the domain organization A1-A2-B-A3-C1-C2. Upon thrombin activation, the B-domains of both molecules are released. Previous studies on factor VIII showed that the B-domain was not required for thrombin cleavage or activity. In contrast, deletion of the factor V B-domain (residues 709 to 1545) yielded a molecule with sevenfold reduced procoagulant activity that was not cleaved by thrombin. However, this factor V B-domain deletion molecule was activated by factor Xa, although the fold-activation was 85% that of wild-type facto

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7

Kyriánová, I. A., J. Vadlejch, and I. Langrová. "Eimeriosis Seasonal Dynamics Patterns at an Organic Sheep Farm in the Czech Republic." Scientia Agriculturae Bohemica 48, no. 2 (2017): 70–75. http://dx.doi.org/10.1515/sab-2017-0013.

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Abstract This epidemiological study monitored the occurrence of the coccidia genus Eimeria and their species composition over a oneyear period at an organic sheep farm in the Czech Republic. Individual faecal samples were collected from thirty lambs and thirty ewes once a month throughout the whole survey. As a result, 348 and 333 samples from ewes and lambs respectively were evaluated using the faecal flotation technique. The overall prevalence of eimeriosis was 75.7% and 54.0% for lambs and ewes respectively. Four Eimeria species (E. ovinoidalis, E. crandallis/weybridgensis, E. parva, and E.

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Necchi, Andrea, Luigi Mariani, Nicola Nicolai, et al. "Modified cisplatin, etoposide, and ifosfamide (PEI) salvage therapy for male germ-cell tumors (GCT): Long-term efficacy and safety outcomes." Journal of Clinical Oncology 31, no. 6_suppl (2013): 328. http://dx.doi.org/10.1200/jco.2013.31.6_suppl.328.

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328 Background: Second-line chemotherapy (CT) of advanced GCT is vividly debated and no standard of care has been established. Since 1985 we introduced the modified PEI combination with the aim to reduce toxicity while maintaining efficacy over the original regimen. Methods: We retrieved data of pts who received ifosfamide at 2.5 gr/m2 (with mesna) on days 1-2, etoposide and cisplatin at 100 mg/m2 and 33 mg/m2, respectively, on days 3-5 every 21 days for a maximum of 4 cycles, followed by surgery of residuals. Multivariable analysis (MVA) was undertaken for pre-specified variables and IGCCCG-2

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Guerroué, Pascale Le, Gérard Cariou, Emmanuelle Poupon, and François Xavier Merlin. "Recovery of Sunken and Buried Oil in Coastal Water During the Erika Spill." International Oil Spill Conference Proceedings 2003, no. 1 (2003): 551–58. http://dx.doi.org/10.7901/2169-3358-2003-1-551.

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ABSTRACT The Erika spilled a very high density, high PAH content persistent heavy fuel oil that impacted over 400 kms of France's West Brittany coastline resulting in a protracted period of shoreline cleanup. One of the sites oiled by the HFO was Pen Bron, located seaward of the Croisic salt marshes. This laarge and very environmentally sensitive area with extensive salt pans and bivalve production was polluted by a significant spill of sunken oil buried in the sediment. In view of the risk to local resources and amenities, operations were undertaken to remedy the sunken oil spill: the polluti

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Dent, Andrew W., Tracey J. Weiland, Lisa Vallender, and Nicola E. Oettel. "Can medical admission and length of stay be accurately predicted by emergency staff, patients or relatives?" Australian Health Review 31, no. 4 (2007): 633. http://dx.doi.org/10.1071/ah070633.

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Objectives: To determine the accuracy of predictions of the need for hospital admission and, if admitted, length of stay (LOS) made early in an emergency attendance by emergency department (ED) doctors, nurses, patients and relatives, and the characteristics of ED presentations predictive of admission and short stays (~3 days). Methods: Prospective collection of predictions by medical and nursing staff, patients and relatives of ED departure status and LOS (1 day, 2-3 days, 4- 7 days or longer) of a convenience sample of adults presenting with medical symptoms. Predictions were made before ful

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Marquette, KA, DD Pittman, and RJ Kaufman. "The factor V B-domain provides two functions to facilitate thrombin cleavage and release of the light chain." Blood 86, no. 8 (1995): 3026–34. http://dx.doi.org/10.1182/blood.v86.8.3026.3026.

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Abstract Blood coagulation factors V and VIII are homologous proteins that have the domain organization A1-A2-B-A3-C1-C2. Upon thrombin activation, the B-domains of both molecules are released. Previous studies on factor VIII showed that the B-domain was not required for thrombin cleavage or activity. In contrast, deletion of the factor V B-domain (residues 709 to 1545) yielded a molecule with sevenfold reduced procoagulant activity that was not cleaved by thrombin. However, this factor V B-domain deletion molecule was activated by factor Xa, although the fold-activation was 85% that of wild-t

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12

Lin, En, Hongguang Liu, Xinlin He, Xinxin Li, Ping Gong, and Ling Li. "Water–Nitrogen Coupling Effect on Drip-Irrigated Dense Planting of Dwarf Jujube in an Extremely Arid Area." Agronomy 9, no. 9 (2019): 561. http://dx.doi.org/10.3390/agronomy9090561.

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Hami, Xinjiang, is located in an extremely arid region and jujube is the main economic crop. It is important to adopt dwarf and close-planting technology under drip irrigation and to optimize water and fertilizer management to improve jujube yield and quality. Local 12-year-old jujube trees were treated using two factors of irrigation and fertilization. Three irrigation amounts (520, 700, and 880 mm) and three fertilization levels (248, 318, and 388 kg/hm2) were set up in plot experiments. The root system, yield, and quality of jujube were monitored under different irrigation and nitrogen appl

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13

Lagenfelt, Hanna, Hakon Blomstrand, and Nils O. Elander. "Real-World Evidence on Palliative Gemcitabine and Oxaliplatin (GemOx) Combination Chemotherapy in Advanced Biliary Tract Cancer." Cancers 13, no. 14 (2021): 3507. http://dx.doi.org/10.3390/cancers13143507.

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Background: Gemcitabine and oxaliplatin (GemOx) is a standard combination regimen in advanced biliary tract cancer (BTC). There is limited evidence on its efficacy and safety in real life. Methods: A retrospective multicentre cohort study in the South East Region of Sweden, covering nine years (2011–2020) and three hospitals where GemOx was treatment of choice, was designed. Clinicopathological prognostic parameters were explored. Results: One hundred and twenty-one patients with advanced BTC were identified. Median overall and progression-free survival (OS and PFS) were 8.9 (95% CI = 7.2–10.6

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Molenda, Tadeusz. "Hydrographic And Hydrochemical Characteristics of the Landslide Lake Jazerske (Spišska Magura, Northern Slovakia)." Limnological Review 18, no. 2 (2018): 77–81. http://dx.doi.org/10.2478/limre-2018-0008.

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Abstract This article presents the hydrographic and hydrochemical characteristics of this lake. Lake Jazerske is located in the Western Carpathians (Spiš Magura) in northern Slovakia. It occupies a depression that was formed at the foot of the main scarp of a landslide. Below the lake, there are small intercolluvial depressions that have been transformed into wetlands (peat bogs). The studied lake is very small. Its area is 3600 m2 and its length is 85 m. The maximum depth of the lake is 7.2 m and its capacity is 17 000 m3. The lake is supplied by an inflow of groundwater via fractured aquifer

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15

Liedtke, C. M. "Bumetanide-sensitive NaCl uptake in rabbit tracheal epithelial cells is stimulated by neurohormones and hypertonicity." American Journal of Physiology-Lung Cellular and Molecular Physiology 262, no. 5 (1992): L621—L627. http://dx.doi.org/10.1152/ajplung.1992.262.5.l621.

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Loop diuretic-sensitive NaCl(K) cotransport plays a fundamental role in absorption and secretion of electrolytes in epithelial tissues. Cotransport activity was measured as uptake of 22Na, 36Cl, or 86Rb at 27 degrees C in isolated rabbit tracheal epithelial cells. Uptake of radiotracer was linear from 1 to 2 min after initiation of radiotracer transport. Bumetanide at 10 microM final concentration did not affect tracer uptake. The endogenous catecholamine l-epinephrine and alpha 2-adrenergic agent clonidine increased sodium and chloride uptake at least 5.5-fold. Bumetanide blocked sodium uptak

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Khan, MR, MS Uddin Shah, MA Aziz, MMR Khan, M. Khalilur Rahman, and Khadiza Khanam. "Homozygotes for HbE and Anaemia -3 Years Study in Rajshahi." TAJ: Journal of Teachers Association 24, no. 1 (2011): 34–37. http://dx.doi.org/10.3329/taj.v24i1.37447.

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HbE is the most common abnormal hemoglobin of Southeast Asia and is almost limited to this region. It is estimated that 30 million people are heterozygous for HbE and that 1 million are homozygous. Aim of this study was to know the number of homozygous for haemoglobin E condition (Hb E disease) patients among patients suspected of having hereditary haemoglobin disorders referred to the regional laboratory, in Rajshahi. From April 2009 to March 2012, anaemic patients suspected of having hereditary haemoglobin disorder (haemoglobinopathy or thalassemia) were referred to the divisional laboratory

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Martins, Vinicius J. B., Paula A. Martins, Janaína das Neves, and Ana L. Sawaya. "Children recovered from malnutrition exhibit normal insulin production and sensitivity." British Journal of Nutrition 99, no. 2 (2008): 297–302. http://dx.doi.org/10.1017/s0007114507793959.

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Protein–energy malnutrition promotes adaptive hormonal changes that result in stunting. A previous study showed that stunted children had increased insulin sensitivity and diminished pancreatic β-cell function. The objectives of the present study were to analyse the glucose, insulin, homeostasis model assessment of insulin sensitivity (HOMA-S) and homeostasis model assessment of pancreatic β-cell function (HOMA-B) levels after nutritional recovery. The recovered group (n 62) consisted of malnourished children after treatment at a nutrition rehabilitation centre. At the beginning of treatment t

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Shouzu, Akira, Seitaro Omoto, Takashi Hayakawa, et al. "Effect of Cilostazol on Soluble Adhesion Molecules and Platelet-derived Microparticles in Patients with Diabetes." Thrombosis and Haemostasis 80, no. 09 (1998): 388–92. http://dx.doi.org/10.1055/s-0037-1615217.

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SummaryWe evaluated the plasma concentrations of soluble adhesion molecules and platelet-derived microparticles (PMP) in patients with non-insulin dependent diabetes mellitus (NIDDM) and studied the effect of cilostazol on PMP generation. There were differences in the levels of soluble adhesion molecules between NIDDM patients (N = 43) and the control subjects (N = 30) (soluble thrombomodulin: 11.5 ± 5.3 vs. 7.0 ± 1.2 TU/ml, p<0.0001; soluble vascular cell adhesion molecule-1: 708 ± 203 vs. 492 ± 113 ng/dl, p<0.0001; soluble intercellular cell adhesion molecules-1: 274 ± 65 vs. 206 ± 48

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Olsen, Flemming Javier, Søren Lindberg, Sune Pedersen, et al. "Global longitudinal strain predicts cardiovascular events after coronary artery bypass grafting." Heart 107, no. 10 (2021): 814–21. http://dx.doi.org/10.1136/heartjnl-2020-318462.

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ObjectiveTo determine the prognostic value of global longitudinal strain (GLS) after coronary artery bypass grafting (CABG).MethodsWe performed a retrospective cohort study on patients undergoing CABG between 2006 and 2011 who had an echocardiogram available for strain analysis. The patients were followed up through nationwide registries for development of all-cause mortality, cardiovascular death (CVD) and major adverse cardiovascular events (MACEs) defined as heart failure hospitalisation and/or CVD. Multivariable Cox regression was applied to adjust for the European System for Cardiac Opera

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Attallah, Ahmed Rady, Shady Eid Al-Elwany, Mohammed A. K. Salama Ayyad, and Ali Mohammed Abdelwahab. "Early clinical outcome after right anterolateral thoracotomy as an alternative for median sternotomy for mitral valve replacement." Egyptian Cardiothoracic Surgeon 2, no. 2 (2020): 47–54. http://dx.doi.org/10.35810/ects.v2i2.111.

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Background: The advantages of the right anterolateral thoracotomy (RALT) approach for mitral valve surgery over standard median sternotomy (MS) are still debatable. The objective of this study was to evaluate and compare the postoperative clinical outcome after RALT and MS for mitral valve replacement. Methods: This prospective observational study included 40 patients who underwent mitral valve replacement between January 2016 and August 2018. Patients were assigned to two groups, the first group included 20 patients who had conventional median sternotomy approach and the second group in

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Mbalaviele, Gabriel, Riko Nishimura, Akira Myoi, et al. "Cadherin-6 Mediates the Heterotypic Interactions between the Hemopoietic Osteoclast Cell Lineage and Stromal Cells in a Murine Model of Osteoclast Differentiation." Journal of Cell Biology 141, no. 6 (1998): 1467–76. http://dx.doi.org/10.1083/jcb.141.6.1467.

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Osteoclasts are multinucleated cells of hemopoietic origin that are responsible for bone resorption during physiological bone remodeling and in a variety of bone diseases. Osteoclast development requires direct heterotypic cell–cell interactions of the hemopoietic osteoclast precursors with the neighboring osteoblast/stromal cells. However, the molecular mechanisms underlying these heterotypic interactions are poorly understood. We isolated cadherin-6 isoform, denoted cadherin-6/2 from a cDNA library of human osteoclast-like cells. The isolated cadherin-6/2 is 3,423 bp in size consisting of an

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Campora, E., M. Schellino, F. Ardissone, et al. "Management of pain in patients (PTS) receiving active therapy for cancer." Journal of Clinical Oncology 25, no. 18_suppl (2007): 19645. http://dx.doi.org/10.1200/jco.2007.25.18_suppl.19645.

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19645 Background: The World Health Organization (WHO) estimates suggest that moderate to severe pain is experienced by one- third of pts receiving active therapy for their disease and by 60–90% of patients with advanced disease. Procedures that make pain assessment and effective management strategies a routine part of every patient care are recommended. The aim of this study was to integrate nursing intervention with physician management of cronic cancer pain experienced by pts receiving active therapy for cancer. Methods: An Oncology Nurse measured pain in all patients (universal screening) p

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Amirdzhanova, V. N., E. Yu Pogozheva, A. E. Karateev, et al. "Rheumatoid arthritis in real clinical practice. Results of the «Computer Terminals of Self-Assessment for Patients with Rheumatic Diseases» («TERMINAL-I») project." Modern Rheumatology Journal 13, no. 2 (2019): 25–30. http://dx.doi.org/10.14412/1996-7012-2019-2-25-30.

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Objective: to describe the portrait of a patient with rheumatoid arthritis (RA) in real clinical practice, to assess disease activity from the point of view of a physician and a patient, functional status, quality of life (QOL), and the efficiency of the therapy performed.Patients and methods. The investigation enrolled 976 RA patients from a cohort of patients in the TERMINAL-I multicenter study, who, when visiting a rheumatologist, independently assessed the disease activity and QOL using a computer system (the «Computer Terminals of SelfAssessment for Patients with Rheumatic Diseases» proje

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JE, Shitaye, B. Getahun, T. Alemayehu, et al. "A prevalence study of bovine tuberculosis by using abattoir meat inspection and tuberculin skin testing data, histopathological and IS6110PCR examination of tissues with tuberculous lesions in cattle inEthiopia." Veterinární Medicína 51, No. 11 (2012): 512–22. http://dx.doi.org/10.17221/5585-vetmed.

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Post mortem surveillances, for the detection of tuberculous lesions in particular depend on the work load time and the diligence of the inspector conducting the examination. The first aim of the study was to determine the trend of occurrence of tuberculous lesions in two abattoirs in Addis Ababa and Debre-Zeit (Ethiopia). The second aim of the study was to determine prevalence of the tuberculin skin test results in 10 dairy farm areas in Addis Ababa. The third aim was to detect tuberculous lesions and causal agents from tissue samples of the respiratory tract and mesenteric lymph nodes of the

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Voskanyan, S. E., A. I. Artemiev, E. V. Naydenov, et al. "ALPPS in overcoming small remnant liver volume in alveolar echinococcosis." Annaly khirurgicheskoy gepatologii = Annals of HPB surgery 23, no. 4 (2019): 21–32. http://dx.doi.org/10.16931/1995-5464.2018421-32.

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Aim.To evaluate the possibilities and indications for ALPPS, immediate and long-term results of surgical treatment of alveolar echinococcosis including great vessels invasion in case of small remnant liver volume.Material and methods. There were 30 ALPPS procedures. Seven patients had small future liver remnant (FLR) — 24.5% (22.4—26.7%). Bile ducts repair with Roux-en-Y procedure for biliodigestive anastomosis during the first surgical stage was performed in 5 patients (71.4%). ALPPS combined with great vessels resection (portal vein or portal vein and left hepatic vein) was required in 4 pat

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Yabe, Michitoshi, Hirotsugu Kenmotsu, Hiroaki Kodama, et al. "Impact of prior ALK-tyrosine kinase inhibitor on pemetrexed-based chemotherapy in patients with advanced ALK positive non-small cell lung cancer." Journal of Clinical Oncology 39, no. 15_suppl (2021): e21113-e21113. http://dx.doi.org/10.1200/jco.2021.39.15_suppl.e21113.

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e21113 Background: In phase Ⅲ trial comparing crizotinib with chemotherapy in patients with ALK-positive non-small-cell lung cancer (NSCLC) patients, it suggests that pemetrexed is highly effective against ALK-positive NSCLC. However, it is unclear that pemetrexed-based chemotherapy is effective in patients previously treated with ALK-tyrosine kinase inhibitor (ALK-TKI) as well as ALK-TKI naïve patients. Therefore, we investigated the impact of prior ALK-TKI therapy on pemetrexed-based chemotherapy. Methods: We retrospectively reviewed 28 ALK positive NSCLC patients who had received pemetrexed

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Ramirez, Francisco E., and Jennifer Hunter. "Effect of Diet on Mental Health on Those Suffering With Premenstrual Syndrome." Journal of the Endocrine Society 5, Supplement_1 (2021): A731. http://dx.doi.org/10.1210/jendso/bvab048.1487.

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Abstract Objective: This study documents the effects that various dietary factors have on mental health among those suffering with premenstrual syndrome (PMS). DESIGN/Methods: N=3231 participants from around the world took an 85 question questionnaire that assessed depression and anxiety using the DSM-5 [The Diagnostic and Statistical Manual of Mental Disorders Volume 5] criteria, as well as various dietary patterns. Depression was classified as: Less than 7 none, 7 to 10 mild, 11 to 19 moderate and more than 20 severe. Results: From n=3231 that took the test, n=1330 reported suffering from PM

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Casal Rubio, J., S. Vázquez Estevez, F. Vázquez Rivera, et al. "Gemcitabine/docetaxel (GD) vs gemcitabine/cisplatin (GC) in stage IIIB/IV advanced non-small cell lung cancer (NSCLC)." Journal of Clinical Oncology 24, no. 18_suppl (2006): 17017. http://dx.doi.org/10.1200/jco.2006.24.18_suppl.17017.

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17017 Background: This trial was designed to compare, in terms of response rates, the standard regimen gemcitabine/cisplatin versus a non-platin regimen, gemcitabine-docetaxel in NSCLC. Methods: The chemotherapy regimens administered were: Arm A: gemcitabine 1250 mg/m2 d1 & 8 plus cisplatin 75 mg/m2 d1; Arm B: gemcitabine 1000 mg/m2 d1 & 8 plus docetaxel 85 mg/m2 d1 repeated every three weeks. Eligibility criteria were measurable stage IV or stage IIIB with pleural effusion NSCLC (brain metastases eligible if asymptomatic) and PS (ECOG Scale) = 0–2. Results: 108 patients (pts) were inc

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Wheelock, Alyse, Meredith Bock, Eva Mihalis, et al. "A randomized trial evaluating the integration of online questionnaires into follow-up (FU) care for early-stage breast cancer (ESBC)." Journal of Clinical Oncology 30, no. 15_suppl (2012): 9107. http://dx.doi.org/10.1200/jco.2012.30.15_suppl.9107.

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9107 Background: Large numbers of cancer survivors have led to the need for FU care addressing lasting effects of BC and its treatment. We conducted a trial evaluating formats of FU care to determine if integration of remote electronic questionnaire FU provides for timely symptom management and more efficient care than routine clinic visits alone. Methods: Patients (pts) with ESBC were randomized to either usual care (UC, frequency of visits determined by oncology providers) with completion of an optional online health and symptom questionnaire (Q) before each clinic visit, or to SIS.NET FU ca

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Al-Hathal, Naif, and Assaad El-Hakim. "Perioperative, oncological, and functional outcomes of the first robotic prostatectomy program in Quebec: Single fellowship-trained surgeon's experience of 250 cases." Canadian Urological Association Journal 7, no. 9-10 (2013): 326. http://dx.doi.org/10.5489/cuaj.319.

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Background: Robotic-assisted radical prostatectomy (RARP) is being increasingly done in Canada. Despite this, the Canadian literature lacks publications on the oncologic and functional outcomes of RARP. The objective of this study is to report the longest single surgeon experience in the province of Quebec.Methods: We collected prospective data from 250 consecutive patients who underwent RARP by a single fellowship trained surgeon (AEH) from October 2006 to October 2012. Mean follow-up was 28 months (range: 1-72). The D’Amico risk stratification distribution was 34% in low-risk, 48% in interme

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Berthold, Frank, Marc Hömberg, and Ole Baadsgaard. "Neuroblastoma metastatic to the central nervous system: Survival analyses from the German Childhood Cancer Registry and the literature." Journal of Clinical Oncology 35, no. 15_suppl (2017): 10555. http://dx.doi.org/10.1200/jco.2017.35.15_suppl.10555.

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10555 Background: Therapeutic innovation has resulted in an overall decline in childhood neuroblastoma (NB) mortality; however, metastatic NB to the central nervous system (CNS NB), which has emerged as a sanctuary site for NB metastases, remains difficult to treat and is typically fatal. The objective of this study was to describe the natural course of CNS NB. Methods: Data were sourced from a custom query of the German Childhood Cancer Registry (GCCR) and from the literature. Survival statistics were prepared from a diverse, thus generalizable, pool of CNS NB patients. Data are presented as

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Alvarez Reguera, C., D. Martínez-López, L. Sanchez Bilbao, et al. "AB0458 SYSTEMIC TREATMENT IN BEHÇET’S DISEASE ACCORDING TO CLINICAL PHENOTYPES. STUDY OF 111 PATIENTS." Annals of the Rheumatic Diseases 79, Suppl 1 (2020): 1527.2–1528. http://dx.doi.org/10.1136/annrheumdis-2020-eular.5005.

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Background:Behçet’s disease (BD) is a multisystemic vasculitis. Different clinical phenotypes can be distinguished. Systemic corticosteroids are the most used drugs in BD. Conventional and biological immunosuppressants (IS) may also be used.Objectives:To evaluate the systemic treatment of BD according to clinical domains.Methods:Study of all consecutive 111 patients diagnosed with definitive or possible BD by expert rheumatologists in a well-defined population of Northern Spain, between 1980 and 2019. Most of them met the International Criteria for BD (ICBD) (1).Results:We studied 111 patients

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Salilew-Wondim, D., I. Ahmad, S. Gebremedhn, et al. "111 REGULATORY microRNA ENRICHMENT AND DEGRADATION IN GRANULOSA CELLS DURING BOVINE FOLLICULAR RECRUITMENT AND DOMINANCE." Reproduction, Fertility and Development 26, no. 1 (2014): 169. http://dx.doi.org/10.1071/rdv26n1ab111.

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Follicular development is a result of complex hormonal and biochemical synergies that could be activated or deactivated in a spatiotemporal manner in oocytes and surrounding cells including theca, granulosa, and cumulus cells. The microRNA (miRNA), 19 to 22 nucleotides noncoding RNA, are one of the molecular cues that could play a role in posttranscriptional regulation of genes involved in follicular development. Here we aimed to understand the availability and abundance of miRNA in bovine granulosa cells (GC) derived from subordinate (SF) and leading or dominant (DF) follicles during bovine f

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Michel, Gérard, Dominique Valteau-Couanet, Hélène Esperou, et al. "A New Busulfan Fixed Dosing for Conditioning before Autologous or Allogeneic Hematopoietic Stem Cell Transplantation in Children with Malignant and Non-Malignant Diseases: Pharmacokinetics, Toxicity and Clinical Outcomes." Blood 106, no. 11 (2005): 1758. http://dx.doi.org/10.1182/blood.v106.11.1758.1758.

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Abstract Background: Oral busulfan (Bu) is a standard component of hematopoietic stem cell transplantation (HSCT) regimens in pediatric patients (pts). Bu exposure (AUC) has been correlated with outcomes, thus dose adjustment and therapeutic drug monitoring (TDM) were needed. An IV Bu formulation would allow to target AUC and improve outcomes of HSCT. We previously reported that a new IV Bu fixed dose based on body-weight calculation can successfully target a therapeutic AUC in children without any dose-adjustment and TDM [Vassal G. et al., ASCO2005;# 8535]. We report here the pharmacokinetics

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Kumar, Priya, Todd E. Defor, Claudio Brunstein, et al. "Allogeneic Hematopoietic Stem Cell Transplantation (HSCT) in the Treatment of Acute Lymphocytic Leukemia (ALL) in 126 Adults: Impact of Donor Source on Leukemia Free Survival (LFS)." Blood 106, no. 11 (2005): 2064. http://dx.doi.org/10.1182/blood.v106.11.2064.2064.

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Abstract White blood cell (WBC) count and specific cytogenetic abnormalities at diagnosis, patient age and disease status at HSCT have previously been identified as risk factors associated with LFS in patients with ALL. As the use of umbilical cord blood (UCB) is relatively new, particularly for adults, we sought to evaluate the relative impact of donor source. In this single center study, 126 adults aged 18–61 (median 31) years (yrs) underwent myeloablative conditioning (cyclophosphamide 120 mg/kg and total body irradiation 1320–1375 cGy based regimen in 92%) followed by allogeneic HSCT. Stem

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Sirohi, Bhawna, Vipul Sheth, Ashish Singh, et al. "Use of gemcitabine-platinum (Gem-P) in patients with advanced gall bladder (GB) cancer: A more aggressive disease compared to the West—Tata Memorial Centre (TMC) experience." Journal of Clinical Oncology 32, no. 3_suppl (2014): 349. http://dx.doi.org/10.1200/jco.2014.32.3_suppl.349.

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349 Background: GB cancer is a common cancer in northern India. Gem-P is currently the standard of care for pts with advanced biliary tract cancers based on the ABC02 study which had 61 pts with GB cancer with a clinical benefit rate (CR+PR+SD) of 85%. Indian patients have a higher risk disease and present at a more advanced stage than in the West and data on treatment is lacking. Methods: This is retrospective analysis of the prospectively maintained database of 131 pts with advanced GB cancer treated at TMC between Jan 2012-May 2013. Aim of the study is to assess the clinical benefit rate in

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Kim, Richard D., William P. Harris, Max W. Sung, et al. "Results of a phase Ib study of regorafenib (REG) 80 mg/day plus pembrolizumab (PEMBRO) for first-line treatment of advanced hepatocellular carcinoma (HCC)." Journal of Clinical Oncology 39, no. 3_suppl (2021): 323. http://dx.doi.org/10.1200/jco.2021.39.3_suppl.323.

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323 Background: In a phase Ib study, REG 120 mg/day plus PEMBRO for first-line treatment of advanced HCC showed no unexpected safety signals and encouraging anti-tumor activity. At the maximum tolerated dose (MTD) of REG (120 mg/day), approximately three-quarters of patients (pts) had a REG dose reduction or interruption due to a treatment-emergent adverse event (TEAE). Here, we present preliminary data for the REG 80 mg/day cohort. Methods: This is an ongoing, dose-finding study in pts who had no prior systemic therapy. In the first cohort, pts received REG 120 mg/day orally for 3 weeks on/1

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Beckmann, Erik, Andreas Martens, Heike Krüger, et al. "Aortic valve-sparing root replacement with Tirone E. David’s reimplantation technique: single-centre 25-year experience." European Journal of Cardio-Thoracic Surgery 60, no. 3 (2021): 642–48. http://dx.doi.org/10.1093/ejcts/ezab136.

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Abstract OBJECTIVES Tirone E. David described aortic valve-sparing root reimplantion (AVSRR) almost 30 years ago. At our centre, we adopted this operation in 1993, and since then, we have performed &gt;700 operations over a time period of &gt;25 years. In this report, we present our single-centre experience. METHODS Between 1993 and 2019, a total of 732 patients underwent AVSRR at our centre. The mean age was 53 ± 15 and 522 (71%) were male. Marfan syndrome was present in 117 (16%) patients and bicuspid aortic valve in 81 (11%). The indication for surgery was aortic root aneurysm in 58

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Regierer, A., A. Weiß, M. Bohl-Buehler, et al. "OP0225 DEPRESSIVE SYMPTOMS IN PSA: A CROSS-SECTIONAL ANALYSIS FROM THE NATIONAL GERMAN RABBIT-SPA REGISTRY." Annals of the Rheumatic Diseases 80, Suppl 1 (2021): 135.2–136. http://dx.doi.org/10.1136/annrheumdis-2021-eular.2130.

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Background:Psoriatic arthritis (PsA) is a chronic inflammatory disease affecting the musculoskeletal system as well as skin and nails. The prevalence of depression in psoriasis and PsA is high and ranges from 7-40% [1]. Persistent depressive mood may influence disease activity outcome in PsA, especially patient-reported outcomes.Objectives:To assess the correlation of depressive symptoms with PsA-specific outcome parameters.Methods:RABBIT-SpA is a prospective longitudinal cohort study including PsA patients enrolled at start of a new conventional treatment or b/tsDMARD treatment. In regularly

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Othieno-Abinya, Nicholas Anthony, Alice Musibi, Catherine Nyongesa, et al. "Final report of Breast Cancer Care Registry at the Kenyatta National Hospital, Nairobi." Journal of Clinical Oncology 39, no. 15_suppl (2021): e12552-e12552. http://dx.doi.org/10.1200/jco.2021.39.15_suppl.e12552.

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Retraction The abstract by Othieno-Abinya et al entitled, “Final report of Breast Cancer Care Registry at the Kenyatta National Hospital, Nairobi,” published in the Journal of Clinical Oncology 39, no. 15 suppl (May 20, 2021) e12552-e12552, was retracted by the authors as it did not meet the study sponsor's prior scientific verification and approval. This abstract was retracted on June 29, 2021. e12552 Background: Breast cancer is the commonest cancer among women in Kenya. We wanted to examine breast cancer seen at the Kenyatta National Hospital in relation to local factors that influence prog

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Lam, S. H. M., H. So, I. T. Cheng, et al. "POS1079 ASSOCIATION OF C-REACTIVE PROTEIN AND NON-STEROIDAL ANTI-INFLAMMATORY DRUGS WITH CARDIOVASCULAR EVENTS IN PATIENTS WITH PSORIATIC ARTHRITIS: A TIME-DEPENDENT Cox REGRESSION ANALYSIS." Annals of the Rheumatic Diseases 80, Suppl 1 (2021): 818.2–819. http://dx.doi.org/10.1136/annrheumdis-2021-eular.3118.

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Background:Psoriatic arthritis (PsA) is associated with accelerated atherosclerosis due to underlying inflammation. Whether inflammatory burden and drugs used to suppress inflammation over time are associated with cardiovascular (CV) events remains unclear.Objectives:This study aims to examine the time-varying effect of C-reactive protein (CRP) levels and the use of drugs including non-steroidal anti-inflammatory drugs (NSAIDs) on the risk of CV events independent of traditional CV risk factors in PsA patients.Methods:A retrospective cohort analysis was performed in patients with PsA who were

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Li, Chi Kong, Vincent Lee, Frankie WT Cheng, et al. "Unrelated Umbilical Cord Blood Transplant for Children with Leukemia: Single or Double Unit Transplant." Blood 112, no. 11 (2008): 4422. http://dx.doi.org/10.1182/blood.v112.11.4422.4422.

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Abstract Unrelated umbilical cord blood transplant (UCBT) was performed in 24 children (16 M, 8 F) with leukemia in a single institution from June 1998 to May 2008. The leukemia types were Acute Lymphoblastic Leukemia (ALL, n=13), Acute Myeloid Leukemia (AML, n=9) and Juvenile Myelomonocytic Leukemia (JMML, n=2). The disease status was CR2 in 13, CR3/4 in 3, refractory or relapse in 8. Fifteen patients received single unit (SU) and 9 patients received double unit (DU) UCBT. The mean age and body weight were 5.7 ± 3.7 year and 19.5 ± 7.9 kg for SU, 7.7 ± 4.0 year and 24.6 ± 9.9 kg for DU, respe

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Quintas-Cardama, Alfonso, Xin Han, Hagop Kantarjian, and Jorge Cortes. "Dasatinib-Induced Platelet Dysfunction." Blood 110, no. 11 (2007): 2941. http://dx.doi.org/10.1182/blood.v110.11.2941.2941.

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Abstract Dasatinib is efficacious and safe in patients (pts) with chronic myelogenous leukemia (CML) after imatinib failure. However, dasatinib therapy has been linked to bleeding in some pts, typically affecting mucosal surfaces. We analyzed the effect of dasatinib on basic coagulation tests and platelet aggregation function in 55 pts with CML in chronic phase at diagnosis (1), >8 weeks after tyrosine kinase inhibitor (TKI) discontinuation (3), or during therapy with the ABL/SRC inhibitors dasatinib (n=27) and bosutinib (n=12), or the aminopyrimidine derivatives imatinib (n=8) and nilotini

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Liefting, L. W., Z. Perez-Egusquiza, and G. R. G. Clover. "First Report of Helleborus net necrosis virus in Hellebore in New Zealand." Plant Disease 94, no. 4 (2010): 479. http://dx.doi.org/10.1094/pdis-94-4-0479b.

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Hellebores (Helleborus spp.) are widely grown in gardens for their winter and early spring flowers. They are extremely hardy and will grow easily in many different environments. In April 2009, black streaks on the leaves and stems were observed on approximately 3 to 5% of hellebores in a home garden in the Waikato Region, New Zealand. The symptoms appeared similar to those of ‘black death’, determined to be associated with a newly characterized carlavirus termed Helleborus net necrosis virus (HeNNV) (1). Transmission electron microscopy revealed the presence of typical carlavirus-like particle

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Ансарін Алі Акбар та Джаваді Шалал. "Маскований семантичний/ асоціативний та перекладний праймінг у різних мовах". East European Journal of Psycholinguistics 5, № 1 (2018): 7–15. http://dx.doi.org/10.29038/eejpl.2018.5.1.ans.

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Статтю присвячено спробі дослідити двомовний ментальний лексикон. Головне питання дослідження – встановити, чи персько-англійські білінгви можуть досягнути ефекту семантичного / асоціативного або перекладацького праймінгу. Для відповіді на це питання було застосовано масковану праймінгову парадигму як техніку, що відображає автоматичні когнітивні процеси, що тривають під час семантичної обробки, а не стратегічного використання прайму. Із метою вирішення лексичного завдання було сформовано чотири типи цільових пар праймінгу (перекладацькі еквіваленти, семантично подібні, асоціативно та семантич

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Cappellini, M. D., P. Giardina, J. Porter, et al. "Long-Term Safety and Tolerability of the Once-Daily, Oral Iron Chelator Deferasirox (Exjade®, ICL670) in Patients with Transfusional Iron Overload." Blood 108, no. 11 (2006): 1768. http://dx.doi.org/10.1182/blood.v108.11.1768.1768.

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Abstract Introduction: The safety and tolerability profile of the oral iron chelator deferasirox has been established in five comprehensive trials (with a 1-year core phase) in adults and children with a range of transfusion-dependent anemias. Following completion of the core phase, pts entered an extension phase that will last for 4 years. This analysis presents cumulative long-term safety data during deferasirox treatment. Methods: Safety was assessed monthly, primarily by evaluating the incidence and type of adverse events (AEs) and measuring laboratory parameters. Results: A total of 1033

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Lisukov, Igor, Alexander Kulagin, Alexey Maschan, et al. "Effect of Eculizumab on Physician-Reported Symptoms in the Russian Cohort of the Paroxysmal Nocturnal Hemoglobinuria (PNH) International Registry." Blood 124, no. 21 (2014): 5163. http://dx.doi.org/10.1182/blood.v124.21.5163.5163.

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Abstract Background: Paroxysmal nocturnal hemoglobinuria is a rare clonal hematopoietic stem cell disease that can lead to life-threatening complications including thrombotic events (TE), chronic kidney disease (CKD) and pulmonary hypertension. In 2011 the International PNH Registry was implemented in the Russian PNH cohort to assess the natural history of PNH and the effects of treatment with eculizumab. Aims:We aim to evaluate the change from baseline to last follow-up in physician-reported symptoms, LDH and hemoglobin concentration in treated and untreated PNH patients. Design and methods:

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Gkikas, Antonis, Vincenzo Obiso, Carlos Pérez García-Pando, et al. "Direct radiative effects during intense Mediterranean desert dust outbreaks." Atmospheric Chemistry and Physics 18, no. 12 (2018): 8757–87. http://dx.doi.org/10.5194/acp-18-8757-2018.

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Abstract. The direct radiative effect (DRE) during 20 intense and widespread dust outbreaks, which affected the broader Mediterranean basin over the period March 2000–February 2013, has been calculated with the NMMB-MONARCH model at regional (Sahara and European continent) and short-term temporal (84 h) scales. According to model simulations, the maximum dust aerosol optical depths (AODs) range from ∼ 2.5 to ∼ 5.5 among the identified cases. At midday, dust outbreaks locally induce a NET (shortwave plus longwave) strong atmospheric warming (DREATM values up to 285 W m−2; Niger–Chad; dust AODs

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Kedev, Sasko, Biljana Zafirovska, Elizabeta Srbinovska-Kostovska, et al. "Minimalistic Approach for Transcatheter Aortic Valve Implantation (TAVI): Open Vascular Vs. Fully Percutaneous Approach." PRILOZI 40, no. 2 (2019): 5–14. http://dx.doi.org/10.2478/prilozi-2019-0009.

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Abstract Background: Aortic stenosis (AS) is the most common valvular heart disease in elderly people. Transcatheter aortic valve implantation (TAVI) has emerged as a revolutionary treatment for elderly patients with symptomatic severe aortic stenosis. The authors present the first experiences with transcatheter aortic valve implantation treatment in Macedonia and compare their findings in regard to differences between open vascular vs. minimalistic transfemoral TAVI approach. Methods: The procedure was performed in 54 patients with severe and symptomatic AS in the period from December 2014 un

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Garibaldi, A., G. Gilardi, D. Bertetti, and M. L. Gullino. "Report of Leaf Blight on Washington Lupine (Lupinus polyphyllus) Caused by Rhizoctonia solani AG 4 in Italy." Plant Disease 93, no. 4 (2009): 429. http://dx.doi.org/10.1094/pdis-93-4-0429a.

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Lupinus polyphyllus (Leguminosae), Washington lupine, is a perennial herbaceous plant. In March 2008, in a campus greenhouse at the University of Torino, Grugliasco (northern Italy), a leaf blight was observed on 20% of potted 30-day-old plants. Semicircular, water-soaked lesions developed on leaves just above the soil line at the leaf-petiole junction and later along the leaf margins. Lesions expanded for several days along the midvein until the entire leaf was destroyed. Blighted leaves turned brown, withered, clung to the shoots, and matted on the surrounding foliage. Severely infected plan

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