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Journal articles on the topic '339.972 (043.2)'

Author: Grafiati

Published: 30 May 2022

Last updated: 31 July 2025

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1

Semenova, Lioubov I., and Allan H. White. "Structural Systematics of Rare Earth Complexes. XVII Hydrated 1 : 1 Adducts of 2,2′:6′,2″-Terpyridine with the Lanthanoid(III) Bromides and Some Binuclear Hydroxy-Bridged Dimers." Australian Journal of Chemistry 52, no. 6 (1999): 539. http://dx.doi.org/10.1071/ch98048.

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Room-temperature single-crystal X-ray structural characterizations are recorded for hydrated lan- thanoid(III) bromide/2,2′:6′,2″-terpyridine (tpy) (1 : 1) complexes, showing all to be ionic and of the form [(tpy)Ln(OH2)x]Br3.yH2O, where x and y are 6 and 1 for the isomorphous series Ln = La(-)Er (and intermediate members, by presumption), and 5 and various values for Ln = Tm, Yb, Lu. Crystals of [(tpy)Ln(OH2)6]Br3.H2O are monoclinic, P 21/c, a ≈ 8·5, b ≈ 18, c ≈ 16·3 Å, β ≈ 108°, Z = 4; for Ln = La, Er, conventional R values on |F| were 0·048, 0·080 for No 4027, 1347 ‘observed’ (I > 3σ(I))

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Marincowitz, Carl, Omar Bouamra, Tim Coates, et al. "1427 The effect of the COVID-19 pandemic on major trauma presentations and patient outcomes in English hospitals." Emergency Medicine Journal 39, no. 12 (2022): A960.2—A964. http://dx.doi.org/10.1136/emermed-2022-rcem2.2.

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Aims, Objectives and BackgroundThere is evidence that COVID-19 ‘lockdowns’ may have contributed to increased non-accidental injury, domestic violence and self-harm related to deteriorating mental health. Internationally, there is also evidence that the diversion of health care resources may led to worse outcomes for patients presenting with major trauma. There has been no previous national evaluation of ‘lockdown’ measures impact on the characteristics, treatment pathways and outcomes of trauma patients in EnglandWe aimed to assess the impact of successive lockdowns on the volume, demographics

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Kuroiwa, K., S. Nakatsuyama, K. Katayama, and T. Nagasawa. "Determination of alpha 2-macroglobulin-trypsin complex with a new synthetic substrate." Clinical Chemistry 35, no. 11 (1989): 2169–72. http://dx.doi.org/10.1093/clinchem/35.11.2169.

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Abstract We have developed a colorimetric assay for quantifying alpha 2-macroglobulin-trypsin complex (alpha 2M-TRY) in human serum, based on use of a new chromogenic substrate D-gamma-tert-butyloxy-Glu-Gly-Arg-3-carboxy-4-hydroxyanilide dihydrochloride (PS-3001). Within-run CVs by this assay were 4.76%, 1.57%, and 0.83% for trypsin complex concentrations of 3.1, 12.2, and 48.1 U/L, respectively (n = 10 each). Between-day CVs were 5.38%, 3.12%, and 2.20% at each concentration, respectively (n = 7). Mean analytical recoveries of alpha 2M-TRY added to serum were 100%, 105%, and 101% for 9.2, 15.

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Hernández-Cruz, B., M. J. Miranda García, J. Barrera, et al. "AB1030 PATIENT CARE AT THE FRACTURE LIAISON SERVICE REDUCE THE GAP IN THE TREATMENT OF OSTEOPOROSIS BETWEEN MEN AND WOMEN." Annals of the Rheumatic Diseases 81, Suppl 1 (2022): 1638–39. http://dx.doi.org/10.1136/annrheumdis-2022-eular.4150.

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BackgroundOsteoporosis (OP) between men and women is different,and the way it is treated also differs. In men, the gap in clinical care, especially diagnosis and treatment, is worse.ObjectivesTo analyze the differences in the clinical characteristics of OP (demographics, comorbidities, diagnosis, and treatment) in an gold star Fracture Liaison Service (FLS).MethodsDesign: Observational, prospective, analytical study of usual clinical practice. All patients treated from an FLS from May 2018 to August 2021 were prospectively included. Of each patient, 160 clinical variables were introduced in a

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Santi, E. N., W. Murdianto, N. R. Ahmadi, Waryat, and A. Sulistyaningrum. "Physicochemical Characteristics of Three Local Sweet Potato Flour from East Kalimantan." IOP Conference Series: Earth and Environmental Science 1024, no. 1 (2022): 012037. http://dx.doi.org/10.1088/1755-1315/1024/1/012037.

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Abstract The character of local sweet potato flour is needed to give good results in food production. This research aims to investigate the physicochemical and functional properties of three verieties of sweet local potato flour from East Kalimantanr i.e Sawenter, White and Purple Kutim. The flour making process includes sorting, cleaning, peeling, soaking in metabisulfite 0.3%, draining, slicing, drying, milling and sieving. The results has a yield ranging from 26.93 to 28.86%; water content of 2.53 to 3.75% w/w; ash content of 1.95 to 5.11% w/w; protein content of 1.63 - 2.38% w/w; fat conte

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Puteri, Ni Made Martini, Hamdi Muluk, Amarina Ariyanto, and Bagus Takwin. "THE MEANING OF GRATIFICATION, MORAL CREDENTIAL, AND THE VALUE OF SELFLESSNESS ACTION IN VIOLATIONS COMMITTED BY A RESPECTED PERSON." Jurnal Psikologi 19, no. 4 (2020): 373–87. http://dx.doi.org/10.14710/jp.19.4.373-387.

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This study aims to prove how kindness conducted by the group, the definition of violations and the value of doing good, can affect moral credential in the form of the leniency of punishment for corruptors. Sample 319 polices and doctors divided into two segments. This study uses a population-based survey experiment method. Participants divided into moral credential with the narrative noble duty, and non-moral credential with neutral narratives. Researchers require each participant to provide criminal punishment and social reactions to the vignette of violation cases due to receiving gratificat

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Chibaudel, Benoist, Frédérique Maindrault-Goebel, Gérard Lledo, et al. "Can Chemotherapy Be Discontinued in Unresectable Metastatic Colorectal Cancer? The GERCOR OPTIMOX2 Study." Journal of Clinical Oncology 27, no. 34 (2009): 5727–33. http://dx.doi.org/10.1200/jco.2009.23.4344.

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PurposeThis study compared chemotherapy discontinuation with maintenance therapy with leucovorin and fluorouracil after six cycles of folinic acid, fluorouracil, and oxaliplatin (FOLFOX) chemotherapy in the first-line treatment of metastatic colorectal cancer.Patients and MethodsTwo hundred two patients with untreated metastatic colorectal cancer were randomly assigned to receive six cycles of modified FOLFOX7 (mFOLFOX7) followed by simplified leucovorin plus bolus and infusional fluorouracil until progression (arm 1 or maintenance arm, n = 98) or six cycles of mFOLFOX7 before a complete stop

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8

Pirogov, Yuriy I., Galina M. Butina, Roman A. Morozov, et al. "Our experience of bromfenac-containing NSAID use in patients after cataract surgery." Ophthalmology journal 9, no. 2 (2016): 53–56. http://dx.doi.org/10.17816/ov9253-56.

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Postoperative cystoid macular edema is an autoimmune reaction due to the blood-retinal barrier breakdown occurring at anterior segment inflammation. Aim: To analyze the effectiveness of various anti-inflammatory therapeutic schemes used in cataract surgery. Materials and methods. Phacoemulsification using similar consumables had been performed in 792 patients (932 eyes). They were divided into three groups: 1st group included patients receiving 1 to 3 dexamethasone (0.3 ml) and mesatone (0.1 ml) injections and Tobradex eye drops starting with 5 times a day for 4-5 weeks and then tapering (356

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Tan, Juanyi, Szu-Chun Yang, Michaela A. Dinan, Anne C. Chiang, Cary P. Gross, and Shi-Yi Wang. "Biomarker-Specific Survival and Medication Cost for Patients With Non–Small Cell Lung Cancer." JAMA Network Open 8, no. 6 (2025): e2514519. https://doi.org/10.1001/jamanetworkopen.2025.14519.

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ImportanceTargeted therapies and immunotherapies prolong survival but are associated with high costs for patients with advanced non–small cell lung cancer (aNSCLC). To date, little is known about survival and medication cost by biomarker status in the US.ObjectiveTo estimate survival and medication cost by aNSCLC biomarker status.Design, Setting, and ParticipantsThis retrospective cohort study using Flatiron Health data identified patients diagnosed with aNSCLC from January 1, 2016, through December 31, 2022. Each patient had received at least 1 biomarker test and 1 documented line of therapy;

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Agasiev, A. R. "Influence of concomitant diseases on health resort treatment in patients with coronary heart disease." Kazan medical journal 96, no. 5 (2015): 744–48. http://dx.doi.org/10.17750/kmj2015-744.

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Aim. To study the influence of concomitant diseases on health resort treatment of patients with coronary heart disease in recreation period. Methods. The study performed in «Bilgah» cardiologic resort, which applies the standards of health resort treatment. General sample included 3421 patients with confirmed diagnosis of «coronary heart disease». Patients were grouped according to the number of concomitant diseases (0, 1, 2, 3 or more). In each group, the frequency of prescribing the certain treatment methods was determined. Results. The vast majority (94.5±0.4%) of patients with

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Bari, Shahla, Marco Matejcic, Richard D. Kim, et al. "Practice Patterns and Survival Outcomes of Immunotherapy for Metastatic Colorectal Cancer." JAMA Network Open 8, no. 3 (2025): e251186. https://doi.org/10.1001/jamanetworkopen.2025.1186.

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ImportanceImmune checkpoint inhibitors (ICIs) have been approved for treatment of microsatellite instable (MSI-H) metastatic colorectal cancer (mCRC), but factors associated with receipt and efficacy of ICIs in routine clinical practice remain largely unknown.ObjectiveTo identify factors associated with receipt of ICIs and associated survival outcomes among patients with mCRC in routine clinical practice.Design, Setting, and ParticipantsThis population-based cohort study used deidentified data from a nationwide electronic health record–derived database to include 18 932 patients diagnosed with

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Pedersen, J. K., K. Andersen, A. J. Svendsen, and K. Hørslev-Petersen. "THU0145 INDICATIONS AND INCIDENCE OF TREATMENT WITH ANTIDEPRESSANTS IN PATIENTS WITH RHEUMATOID ARTHRITIS AND MATCHED CONTROLS." Annals of the Rheumatic Diseases 79, Suppl 1 (2020): 288.2–288. http://dx.doi.org/10.1136/annrheumdis-2020-eular.976.

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Background:The incidence of depression is about 1.5-2 times higher in patients with rheumatoid arthritis (RA) versus controls. (1, 2) Previous data on treatment with antidepressants has pointed to an almost equal distribution of indications between depression and other indications. (3)Objectives:To describe and compare indications and the incidence of treatment with antidepressants in patients with RA and matched controls.Methods:The study involved an inception cohort of patients with incident RA ascertained from 1995 to 2002 according to the American College of Rheumatology 1987 classificatio

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de Vries, Joost C., Maaike K. van Gelder, Anneke S. Monninkhof, et al. "A Uremic Pig Model for Peritoneal Dialysis." Toxins 14, no. 9 (2022): 635. http://dx.doi.org/10.3390/toxins14090635.

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With increasing interest in home dialysis, there is a need for a translational uremic large animal model to evaluate technical innovations in peritoneal dialysis (PD). To this end, we developed a porcine model with kidney failure. Stable chronic kidney injury was induced by bilateral subtotal renal artery embolization. Before applying PD, temporary aggravation of uremia was induced by administration of gentamicin (10 mg/kg i.v. twice daily for 7 days), to obtain uremic solute levels within the range of those of dialysis patients. Peritoneal transport was assessed using a standard peritoneal pe

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Ordas, Jorge Anton D., Yen-Ting Chen, Eiana Joshier A. Odulio, Genea Nichole G. Cortez, Sarah Grace S. Zamudio, and Niña Kathryn G. Alfeche. "Two new species of Psychotria L. (Psychotrieae-Rubiaceae) from Dinagat Island, Philippines." Webbia 80, no. 1 (2025): 67–76. https://doi.org/10.36253/jopt-17036.

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Psychotria alejandroi and P. nitidifolia, two new species from Dinagat Island, Philippines, are described and illustrated. Both species belong to the Pilosella species group sensu Sohmer and Davis (2007), characterized by inflorescences with defined axes bearing sessile flowers and fruits. Psychotria alejandroi is similar to P. pilosella but can be distinguished by having truncate, lobed stipules with its inner lobes extending into long aristae, lanceolate to narrowly ovate leaves that are coriaceous and scabrous, longer inflorescences (2–4 cm long), bracts with entire margins, 5- to 6-merous

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Punnett, Angela, Stephanie Terezakis, Lu Chen, Allen Buxton, Suzanne L. Wolden, and Burton Appel. "Outcomes in Adolescents and Young Adults with Hodgkin Lymphoma Treated with and without Radiation Therapy On CCG 5942: A Report From the Children's Oncology Group." Blood 120, no. 21 (2012): 3659. http://dx.doi.org/10.1182/blood.v120.21.3659.3659.

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Abstract Abstract 3659 Background Combined modality therapy with chemotherapy and radiation (RT) has resulted in excellent cure rates for Hodgkin Lymphoma (HL) but is associated with significant late effects. Modern therapeutic protocols attempt to limit cumulative doses of chemotherapy and minimize radiation therapy where possible. There is also growing attention to the optimal management of specific patient populations, including the adolescent and young adult (AYA) population. The CCG trial 5942 provides an opportunity to assess the role of RT in disease control for the AYA population (15–2

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Sasaki, Koji, Ildefonso Ismael Rodriguez-Rivera, Hagop M. Kantarjian, et al. "Correlation of Lymphocyte Count with Treatment Response to Tyrosine Kinase Inhibitors in Newly Diagnosed Chronic Myeloid Leukemia in Chronic Phase." Blood 124, no. 21 (2014): 4538. http://dx.doi.org/10.1182/blood.v124.21.4538.4538.

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Abstract Background: Total lymphocyte count (TLC) has been shown to correlate with outcomes in patients (pts) with acute leukemia. The clinical correlation to TLC in pts with chronic myeloid leukemia in chronic phase (CML-CP) who were treated with a tyrosine-kinase inhibitor (TKI) is unclear. Methods: Lymphocyte data in pts with newly diagnosed CML-CP who were enrolled in consecutive or parallel clinical trials with front-line imatinib (IM), nilotinib (Nilo), or dasatinib (Dasa) were collected at the time of diagnosis, and 3 and 6 months (M) after the start of TKI. Relative lymphocytrosis (RLC

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Suchomel, Timothy J., Kimitake Sato, Brad H. DeWeese, William P. Ebben, and Michael H. Stone. "Relationships Between Potentiation Effects After Ballistic Half-Squats and Bilateral Symmetry." International Journal of Sports Physiology and Performance 11, no. 4 (2016): 448–54. http://dx.doi.org/10.1123/ijspp.2015-0321.

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The purposes of this study were to examine the effect of ballistic concentric-only half-squats (COHS) on subsequent squat-jump (SJ) performances at various rest intervals and to examine the relationships between changes in SJ performance and bilateral symmetry at peak performance. Thirteen resistance-trained men performed an SJ immediately and every minute up to 10 min on dual force plates after 2 ballistic COHS repetitions at 90% of their 1-repetition-maximum COHS. SJ peak force, peak power, net impulse, and rate of force development (RFD) were compared using a series of 1-way repeated-measur

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Bianchi, Paola, Elisa Fermo, Fulvio Mozzi, Maurizio Marconi, and Alberto Zanella. "Presence of JAK2 V617F Mutation in Peripheral Blood of Blood Donors with Upper-Limit Hematocrit and Platelet Values." Blood 110, no. 11 (2007): 2533. http://dx.doi.org/10.1182/blood.v110.11.2533.2533.

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Abstract The somatic mutation V617F of JAK2 gene has been identified as a pathogenic factor in typical chronic myeloproliferative diseases (MPDs), in particular polycythemia vera, essential thrombocythemia, and myelofibrosis with myeloid metaplasia. Recently, two studies showed the presence of this mutation also in 37/3935 subjects with non haematological diseases (Xu et al, 2006) and 5/52 healthy donors (Sidon et al, 2006), suggesting that V617F mutation may occur in the absence of MPD phenotype and that probably is not sufficient per se to induce MPDs. The aim of this study was to search for

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Kelley, Robin Kate, Baek-Yeol Ryoo, Philippe Merle, et al. "Second-line cabozantinib after sorafenib treatment for advanced hepatocellular carcinoma: a subgroup analysis of the phase 3 CELESTIAL trial." ESMO Open 5, no. 4 (2020): e000714. http://dx.doi.org/10.1136/esmoopen-2020-000714.

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ObjectiveIn the phase 3 CELESTIAL trial, cabozantinib improved overall survival (OS) and progression-free survival (PFS) compared with placebo in patients with previously treated advanced hepatocellular carcinoma (HCC). This subgroup analysis evaluated cabozantinib in patients who had received sorafenib as the only prior systemic therapy.MethodsCELESTIAL randomised (2:1) patients with advanced HCC and Child–Pugh class A liver function to treatment with cabozantinib (60 mg daily) or placebo. Eligibility required prior treatment with sorafenib, and patients could have received ≤2 prior systemic

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Issa, Ghayas C., Hagop M. Kantarjian, C. Cameron Yin, et al. "Prognostic Implications of Pre-Treatment Hypodiploidy and Complex Cytogenetics in Adult Patients with Acute Lymphocytic Leukemia (ALL) Treated with Hyper-CVAD." Blood 126, no. 23 (2015): 4874. http://dx.doi.org/10.1182/blood.v126.23.4874.4874.

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Abstract Background Pretreatment cytogenetic analysis is frequently used to predict response and outcome in hematologic malignancies. Hypodiploidy is associated with a poor prognosis in childhood ALL. Similarly, complex cytogenetics is a known adverse prognostic factor in myeloid malignancies. The impact of hypodiploidy and complex cytogenetics has not been extensively assessed in adult patients with ALL. To address this issue, we have conducted a retrospective analysis of all adult patients with ALL treated with frontline Hyper-CVAD based regimens at our institution. Methods We reviewed 332 a

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Zhang, Z., and J. Radziuk. "Effects of lactate on pathways of glycogen formation in the perfused rat liver." Biochemical Journal 280, no. 2 (1991): 415–19. http://dx.doi.org/10.1042/bj2800415.

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In order to investigate the roles of lactate as substrate and regulator of hepatic glycogen synthesis, two groups of rat livers were perfused with oxygenated blood for 2 h. The initial perfusate glucose and lactate concentrations of Group I and II were 245 +/- 6.8 and 254 +/- 12.9 mg/dl and 49 +/- 2.6 and 54 +/- 2.2 mg/dl respectively. Labelled glucose was added to the perfusate to assess direct glycogen formation. Either additional glucose (Group I) or lactate (Group II) was added (1 mg/min) to a recirculating liver-perfusion system. Initial lactate uptake and glucose formation was identical

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O'Driscoll, B. Ronan, Louis Kirton, Mark Weatherall, et al. "Effect of a lower target oxygen saturation range on the risk of hypoxaemia and elevated NEWS2 scores at a university hospital: a retrospective study." BMJ Open Respiratory Research 11, no. 1 (2024): e002019. http://dx.doi.org/10.1136/bmjresp-2023-002019.

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BackgroundThe optimal target oxygen saturation (SpO2) range for hospital inpatients not at risk of hypercapnia is unknown. The objective of this study was to assess the impact on oxygen usage and National Early Warning Score 2 (NEWS2) of changing the standard SpO2target range from 94–98% to 92–96%.MethodsIn a metropolitan UK hospital, a database of electronic bedside SpO2measurements, oxygen prescriptions and NEWS2 records was reviewed. Logistic regression was used to compare the proportion of hypoxaemic SpO2values (<90%) and NEWS2 records ≥5 in 2019, when the target SpO2range was 94–98%; w

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Yoo, Changhoon, Min-Hee Ryu, Byung Woog Kang, et al. "Cross-Sectional Study of Imatinib Plasma Trough Levels in Patients With Advanced Gastrointestinal Stromal Tumors: Impact of Gastrointestinal Resection on Exposure to Imatinib." Journal of Clinical Oncology 28, no. 9 (2010): 1554–59. http://dx.doi.org/10.1200/jco.2009.26.5785.

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Purpose Imatinib plasma trough levels (Cmin) have been reported to correlate with treatment outcomes in patients with gastrointestinal stromal tumors (GISTs). We therefore have evaluated the correlation between imatinib Cmin and the clinical characteristics of patients with GIST. Patients and Methods Steady-state imatinib Cmin in 107 patients with GIST who were taking imatinib 300 to 800 mg/d was measured. Results In patients treated with imatinib 400 (n = 92), 300 (n = 7), 600 (n = 2), or 800 (n = 11) mg/d, imatinib Cmin was 1,305 ± 633 ng/mL, 1,452 ± 830 ng/mL, 1,698 ± 725 ng/mL, and 3,330 ±

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S, Lippa, Bailie J, Brickell T, French L, Hungerford L, and Lange R. "A-116 Predicting Chronic Neurobehavioral Symptoms based on Acute Injury Characteristics and Symptoms in U.S. Military Service Members with and without history of TBI." Archives of Clinical Neuropsychology 35, no. 6 (2020): 909. http://dx.doi.org/10.1093/arclin/acaa068.116.

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Abstract Objective Recovery following traumatic brain injury (TBI) is complex. Often following mild TBI, recovery occurs within days or weeks, though this is not always the case. Following more severe TBI, some recover quickly, while many never fully recover. This study examines acute predictors of chronic neurobehavioral symptoms in U.S. military service members (Age: M = 33.9 years, SD = 10.2) without injury (n = 86), or with history of uncomplicated mild traumatic brain injury (TBI; n = 56), complicated mild, moderate, or severe TBI (mod-sev TBI; n = 43), or bodily injury (n = 25). Method P

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Sawattep, Jeeranut, Thad A. Howard, Noppawan P. Morales, et al. "Single Nucleotide Polymorphism (SNP) Discovery within the UGT1A Gene Complex: Allelic Frequencies and Ethnic Differences." Blood 104, no. 11 (2004): 3780. http://dx.doi.org/10.1182/blood.v104.11.3780.3780.

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Abstract The UDP-glycosyltransferase (UGT1A) gene complex plays an important role in the hepatic metabolism of many chemicals, toxins, and drugs including bilirubin and acetaminophen. In this large gene complex that spans over 200kb, there are at least 13 different coding regions that can serve as exon 1, followed by a common sequence that contains exons 2–5. These variable exon 1 sequences confer different chemical specificities for binding compounds, while exons 2–5 provide glycosyltransferase function (glucuronidation) that enhances water solubility and excretion. Mutations and polymorphism

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Yan, Ran, Amanda Devine, Evania Marlow, et al. "Resistant Starch Intake Is Low in Australian Adults With Irritable Bowel Syndrome Who Follow a Low FODMAP Diet." Current Developments in Nutrition 6, Supplement_1 (2022): 757. http://dx.doi.org/10.1093/cdn/nzac062.026.

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Abstract Objectives This observational study aimed to assess dietary intake, including resistant starch (RS) in adults with Irritable Bowel Syndrome (IBS), who follow a habitual diet low in Fermentable Oligosaccharides, Disaccharides, Monosaccharides and Polyols (FODMAP) (LFD). Methods Twenty-six participants in Perth, Western Australia with IBS (23 females, aged mean ± SD 37 ± 13 years with a Body Mass Index of 23 ± 3 kg/m2) had FODMAP content assessed using the Monash University Comprehensive Nutrition Assessment Questionnaire and dietary RS from 3-d weighed food diary analysed using publish

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Darwent, A. L., K. N. Harker, and G. W. Clayton. "Perennial sowthistle control with sequential herbicide treatments applied under minimum and zero tillage systems." Canadian Journal of Plant Science 78, no. 3 (1998): 505–11. http://dx.doi.org/10.4141/p97-093.

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Perennial sowthistle (Sonchus arvensis L.) control under minimum and zero tillage systems, and following several sequential in-crop herbicide treatments applied in a crop rotation of canola (Brassica rapa L.) followed by 3 yr of barley (Hordeum vulgare L.), was evaluated in two field experiments near Grande Prairie, Alberta. Under zero tillage, in-crop applications of clopyralid at 0.1 to 0.3 kg active ingredient (a.i.) ha−1 to canola, followed by annual in-crop applications of clopyralid at 0.15 kg a.i. ha−1 plus MCPA at 0.42 kg a.i ha−1 to barley in the next 2 yr, reduced perennial sowthistl

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Clemens, Keelia, Lauren Welch, Nicole Zhang, and Pat Gulhati. "Circulating tumor DNA-based genomic profiling and real-world outcomes in cancer of unknown primary (CUP)." Journal of Clinical Oncology 43, no. 16_suppl (2025): 4200. https://doi.org/10.1200/jco.2025.43.16_suppl.4200.

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4200 Background: CUP accounts for <5% of cancers and carries a dismal prognosis with median overall survival of ~13 months. Studies suggest up to one-third of CUP patients (pts) have a potentially targetable alteration (PTA) that may be eligible for molecularly guided therapy (MGT). Liquid biopsy (LB) is a non-invasive method to identify PTAs and genomic clues regarding primary site via circulating tumor DNA (ctDNA). We characterize the ctDNA landscape of PTAs in CUP and evaluate outcomes for pts receiving MGT. Methods: Real-world data was sourced via GuardantINFORM, a database aggregating

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Odinokova, V. O. "Features of the anatomical structure of the lacrimal ducts taking into account morphometric parameters." Modern technologies in ophtalmology 60, no. 2 (2025): 196–97. https://doi.org/10.25276/2312-4911-2025-2-196-197.

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Relevance The lacrimal ducts play an important role in maintaining eye health. If their function is disrupted, in particular their vertical section, such pathological conditions as epiphora and dacryostenosis may develop. In this regard, the study of the anatomical structure and morphological characteristics of the lacrimal ducts is important for the diagnosis and treatment of ophthalmological diseases. The anatomical structure of the lacrimal ducts is characterized by complex morphometry, ensuring effective drainage of tear fluid. The key parameters are the diameter and length of the lacrimal

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Cappellini, Maria Domenica, Amal El-Beshlawy, Antonis Kattamis, et al. "Efficacy and Safety of Deferasirox (Exjade®) in Patients with Transfusion- Dependent Anemias: 1-Year Results from the Large, Prospective, Multicenter EPIC Study." Blood 112, no. 11 (2008): 3875. http://dx.doi.org/10.1182/blood.v112.11.3875.3875.

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Abstract Background: Deferasirox is a once-daily oral iron chelator with established dose-dependent efficacy for treating transfusional iron overload. In registration trials, the starting dose was based on baseline liver iron concentration (LIC). The prospective multicenter EPIC trial, the largest ever conducted for an iron chelator, included patients (pts) with a variety of transfusion-dependent anemias and was designed to evaluate the efficacy and safety of fixed starting doses of deferasirox based on transfusion history, with subsequent dose titration based on serum ferritin (SF) trends. On

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Pelican, K. M., J. L. Brown, D. E. Wildt, M. A. Ottinger, and J. G. Howard. "18OVARIAN SUPPRESSION WITH THE PROGESTIN LEVONORGESTREL IMPROVES OVULATION INDUCTION FOR ARTIFICIAL INSEMINATION IN THE DOMESTIC CAT." Reproduction, Fertility and Development 16, no. 2 (2004): 131. http://dx.doi.org/10.1071/rdv16n1ab18.

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Ovarian response to gonadotropin stimulation for artificial insemination (AI) is variable in the domestic cat. After ovulation induction with gonadotropins, a secondary wave of corpora lutea (CL) is often produced that alters endocrine profiles. This study assessed the impact of ovarian suppression with the progestin, levonorgestrel, before ovarian stimulation with equine chorionic gonadotropin (eCG) and human chorionic gonadotropin (hCG) on ovarian response in the cat. Queens were assigned randomly to: 1) levonorgestrel (LNG), 6 Norplant® rods implanted for 37d+eCG/hCG (n=6cats); and 2) Contr

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Barreira, S. C., A. R. Cruz-Machado, A. L. Fernandes, et al. "AB1145 PRESCRIPTION PATTERNS AND DISEASE ACTIVITY IN PORTUGUESE WOMEN OF CHILDBEARING AGE WITH RHEUMATOID ARTHRITIS, PSORIATIC ARTHRITIS, ANKYLOSING SPONDYLITIS AND JUVENILE IDIOPATHIC ARTHRITIS." Annals of the Rheumatic Diseases 79, Suppl 1 (2020): 1862.1–1863. http://dx.doi.org/10.1136/annrheumdis-2020-eular.1976.

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Background:Disease activity (DA) at conception is one of the main predictors of pregnancy outcomes in women of childbearing age (WoCBA) with rheumatic diseases. Teratogenicity and unawareness about pregnancy compatibility of some disease-modifying anti-rheumatic drugs might limit the choice of treatment in WoCBA.Objectives:To assess differences in prescription patterns between WoCBA with rheumatoid arthritis (RA), psoriatic arthritis (PsA), ankylosing spondylitis (AS) and juvenile idiopathic arthritis (JIA) and comparator groups, namely postmenopausal women (PMW) and age-matched men. Evaluate

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Bruni, C., M. Occhipinti, G. Camiciottoli, et al. "OP0181 FUNCTIONAL CUT-OFFS TO DISTINGUISH PULMONARY VASCULAR AND PARENCHYMAL INVOLVEMENT IN SYSTEMIC SCLEROSIS (SSC): A QUANTITATIVE ANALYSIS OF IMAGING FEATURES AT CHEST COMPUTED TOMOGRAPHY (CT)." Annals of the Rheumatic Diseases 79, Suppl 1 (2020): 112.1–113. http://dx.doi.org/10.1136/annrheumdis-2020-eular.2188.

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Background:Interstitial lung disease (ILD) and pulmonary arterial hypertension represent the most frequent causes of morbidity and mortality in SSc, with chest CT representing the gold standard in ILD assessment, while FVC and DLco allow functional assessment.Objectives:As qualitative analysis of given chest CT scans is hampered by low reproducibility, we aimed to perform a quantitative analysis (QA) of CT scans able to investigate the parenchymal and vascular features in SSc-ILD and thus testing the relationship with clinical-functional data.Methods:We prospectively enrolled 80 patients who u

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Kolhe, Shivam, Vikas Khanduja, and Ajay Malviya. "EP2.22 Temporal trends and geographical variation of pelvic osteotomy in England from 2010 to 2023." Journal of Hip Preservation Surgery 12, Supplement_1 (2025): i62. https://doi.org/10.1093/jhps/hnaf011.198.

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Abstract Introduction: Hip dysplasia in young adults can be treated by pelvic osteotomies (PO) techniques, including triple and periacetabular osteotomy, which preserve the native hip joint. Despite an increase in clinical interest globally, the trends, demographics and geographical variation of PO remain largely unknown. This study aimed to (1) analyse the temporal trends of PO, and (2) examine the geographical variation of PO across England from 2010 to 2023. Methods: We performed a retrospective review analysing national data from the Hospital Episode Statistics (HES) database in England. W

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Devi, Rama, Balbir Singh, and Deepak Basandrai. "Craniospinal irradiation for medulloblastoma tumors: Retrospective analysis of dosimetric comparison—An institutional study." Journal of Cancer Research and Therapeutics 21, no. 1 (2025): 40–48. https://doi.org/10.4103/jcrt.jcrt_2305_23.

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ABSTRACT Introduction: The comparative study of dosimetric parameters for craniospinal irradiation (CSI) in medulloblastoma cancer patients has been conducted using three different radiation treatment modalities, such as helical intensity-modulated radiation therapy (RT) (HIMRT), helical three-dimensional (3D) conformal RT (H3DCRT), and volumetric modulated arc therapy (VMAT). Evaluation based on dosimetric parameters has been performed to check the better clinical outcomes of recent treatment techniques over one another. Materials and Methods: In this retrospective study, twenty patients have

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Iwawaki, Tomoya, Satoshi Yanagisawa, Yasuya Inden, et al. "Discontinuation of Oral Anticoagulation After Successful Atrial Fibrillation Ablation." JAMA Network Open 8, no. 3 (2025): e251320. https://doi.org/10.1001/jamanetworkopen.2025.1320.

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ImportanceThere is no clear consensus regarding the discontinuation of oral anticoagulants (OACs) after catheter ablation (CA) for atrial fibrillation (AF).ObjectiveTo evaluate thromboembolic and major bleeding events and all-cause death following OAC discontinuation and characteristics associated with patient prognoses after successful CA.Design, Setting, and ParticipantsThis retrospective cohort study included patients without AF recurrence or adverse events 12 months after CA among those undergoing their first CA between January 1, 2006, and December 31, 2021. The study population was divid

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Burkhart, Scott O., Christine Ellis, and Troy M. Smurawa. "ACUTE PERFORMANCE ON A VESTIBULAR AND OCULAR MOTOR SCREENER AND RECOVERY FOLLOWING CONCUSSION." Orthopaedic Journal of Sports Medicine 7, no. 3_suppl (2019): 2325967119S0013. http://dx.doi.org/10.1177/2325967119s00136.

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Background: Concussion injuries are synonymous with vestibular impairments and symptoms include dizziness, impaired balance, and problems with gaze stability (Covassin et al., 2014). Common ocular motor impairments after a concussion include convergence/accommodative insufficiencies and saccadic dysfunction (Mucha et al., 2014). Vestibular and ocular motor impairments have been linked to worse outcomes following concussion (Pearce et al., 2015), including prolonged recovery (Corwin et al., 2015). The purpose of the current study was to determine which VOMS impairments were linked with longer r

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Abacar, K., Ş. Çolakoğlu Özkaya, E. Biyikli, O. Buğdayci, P. Atagündüz, and Z. D. Selcuk. "POS1198-HPR PREVALENCE OF INFLAMMATORY BACK PAIN IN PRIMARY SJOGREN’S SYNDROME IS INCREASED AND ASSOCIATED WITH ACUTE AND STRUCTURAL CHANGES OF THE SACROILIAC JOINT." Annals of the Rheumatic Diseases 82, Suppl 1 (2023): 931.2–931. http://dx.doi.org/10.1136/annrheumdis-2023-eular.6491.

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BackgroundAn increased prevalence of axial articular manifestations has recently been reported in primary Sjögren‘s syndrome (pSS).[1]Radiologic findings associated with inflammatory back pain (IBP) are not well documented in pSS patients.ObjectivesTo assess the prevalence of IBP and its association with magnetic resonance imaging (MRI) detected acute inflammatory and structural changes of sacroiliitis in pSS patients with IBP.MethodsIn this cross-sectional study, consecutive pSS patients fulfilling ACR/EULAR classification criteria and age- and sex-matched healthy controls (HC) were screened

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Eastwood, L. C., C. A. Boykin, M. K. Harris, et al. "National Beef Quality Audit-2016: Transportation, mobility, and harvest-floor assessments of targeted characteristics that affect quality and value of cattle, carcasses, and by-products1." Translational Animal Science 1, no. 2 (2017): 229–38. http://dx.doi.org/10.2527/tas2017.0029.

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Abstract The National Beef Quality Audit-2016 (NBQA-2016) was conducted to assess current transportation, mobility, and quality characteristics of U.S. fed steers and heifers. Data were collected at 17 beef processing facilities between March and November 2016. About 8,000 live cattle were evaluated for transportation and mobility, and about 25,000 carcasses were evaluated on the slaughter floor. Cattle were in transit to the slaughter facility for a mean duration of 2.7 h from a mean distance of 218.5 km using trailers with dimensions ranging from 17.84 m2 to 59.09 m2. Area allotted per anima

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Lee, Rugyeom, Sang Min Lee, Minha Hong, and In-Hwan Oh. "Psychiatric Health Risks in North Korean Refugee Youths Resettled in South Korea." JAMA Network Open 8, no. 5 (2025): e2512941. https://doi.org/10.1001/jamanetworkopen.2025.12941.

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ImportanceMigrant and refugee populations are increasing globally, and children and adolescents in these populations are particularly susceptible to mental disorders. North Korean refugee (NKR) youths now living in South Korea share a culture, language, and history with South Korean (SK) youths, making these 2 groups suitable for studying the environmental factors in psychiatric health.ObjectiveTo compare the risk of developing mental illness and individual psychiatric disorders among NKR youths and SK youths.Design, Setting, and ParticipantsThis cohort study obtained data from Korea’s Nationa

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Berman, Ellin, Maria Nicolaides, Nicolas Sauter, Suzanne Chanel, Brianne Wilson, and Martin Fleisher. "Altered Bone and Mineral Metabolism in Patients Treated with Imatinb." Blood 104, no. 11 (2004): 4668. http://dx.doi.org/10.1182/blood.v104.11.4668.4668.

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Abstract Imatinib is a tyrosine kinase that effectively inhibits the bcr-abl fusion protein in Philadelphia (Ph) chromosome positive CML and c-kit, which is overexpressed in gastrointestinal stomal tumors (GIST). We identified a group of patients treated with Imatinib at Memorial Hospital who developed low phosphate (PO4) levels and studied metabolic bone and mineral parameters associated with this finding. A total of 61 patients who received a prescription for Imatinib from the hospital pharmacy were screened to determine whether a PO4 level had ever been drawn. Of these, 26 had at least one

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Burnett, Alan K., Nigel Russell, Robert K. Hills, et al. "A Comparison of Single Dose Gemtuzumab Ozogamicin 3mg/m2 and 6mg/m2 Combined with Induction Chemotherapy in Younger Patients with AML: Data from the UK NCRI AML17 Trial." Blood 124, no. 21 (2014): 2308. http://dx.doi.org/10.1182/blood.v124.21.2308.2308.

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Abstract On behalf of the UK NCRI AML Study Group. Gemtuzumab Ozogamicin (GO) was the first antibody directed chemotherapy in cancer, but has had a chequered development in AML. We recently completed an individual patient data meta-analysis (Hills et al Lancet Oncology 15 (9): 986-96, 2014) which confirmed, in an analysis of the 5 randomised trials in adults, that simultaneous administration with induction chemotherapy significantly improved survival by reducing relapse risk in favourable and intermediate risk groups, but not in patients with adverse risk. The analysis further suggested that a

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Bos, R., A. Al Hasan, F. Reimann, et al. "POS1438 FRYQ QUESTIONNAIRE DISTINGUISHES INFLAMMATORY FROM NON-INFLAMMATORY DISEASE IN NEWLY REFERRED PATIENTS." Annals of the Rheumatic Diseases 81, Suppl 1 (2022): 1062.2–1063. http://dx.doi.org/10.1136/annrheumdis-2022-eular.3757.

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BackgroundInflammatory Rheumatic Diseases (IRDs) affect 5% of the general population, while 35% of the population experiences Musculoskeletal Complaints (MSCs) [1]. IRDs cause early disability, reduced life-expectancy and considerable health care costs. Early diagnosis is essential to prevent long-term damage, similarly important is the early identification of patients with MSCs without IRDs to prevent unnecessary health care expenses. Of the population referred to the rheumatologist, 60% have non-inflammatory MSCs while only 20% of patients with an IRD see a rheumatologist within three months

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Sheng, Xiaohong, Xiangyang Xin, Liming Wang, Yan Sun, and Xiaohua Li. "Therapeutic effect of Ranibizumab combined with Triamcinolone Acetonide on wet age-related macular degeneration and its effect on interleukin." Discussion of Clinical Cases 7, no. 2 (2020): 18. http://dx.doi.org/10.5430/dcc.v7n2p18.

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Objective: To observe the clinical efficacy of ranibizumab combined with triamcinolone acetonide on wet age-related macular degeneration (AMD) and explore the effect of this method on the levels of IL-1, IL-2, IL-6 and IL-8.Methods: Prospective study was conducted in this research. 86 cases of patients with wet AMD (102 eyes) admitted in Baogang Hospital of Inner Mongolia from November 2017 to October 2018 were chosen and randomly divided into the ranibizumab group (43 cases, 50 eyes) and the combination group (43 cases, 52 eyes). The ranibizumab group of patients were given intravitreal injec

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Batra, Ullas, Shrinidhi Nathany, Mansi Sharma, et al. "MET exon 14 skipping in NSCLC: An unMET Indian need." Journal of Clinical Oncology 42, no. 16_suppl (2024): e13537-e13537. http://dx.doi.org/10.1200/jco.2024.42.16_suppl.e13537.

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e13537 Background: The approval of capmatinib and tepotinib, selective MET tyrosine kinase inhibitors (TKI), has further shifted the therapeutic paradigm of advanced NSCLC. MET exon 14 skipping (MET ex14) alteration is a complex mechanism, reported in ~3-4% cases of NSCLC. Controlled trials have reported remarkable outcomes of selective MET TKIs, however real world outcomes from this part of the world are currently lacking. Methods: This is a non-interventional study reporting real world outcomes of NSCLC with MET ex14 from two apex cancer centers of India. 49 eligible patients were recovered

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Gernsheimer, Terry B., Siobhan P. Brown, Darrell J. Triulzi, et al. "Effects of Tranexamic Acid Prophylaxis on Bleeding Outcomes in Hematologic Malignancy: The a-TREAT Trial." Blood 136, Supplement 1 (2020): 1–2. http://dx.doi.org/10.1182/blood-2020-138920.

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Background: Despite optimal prophylactic platelet (plt) transfusion therapy for severe thrombocytopenia in patients undergoing treatment for hematologic malignancy, WHO Grade 2 or greater bleeding continues to occur at rates of 43% to 70%. Although antifibrinolytic therapy has been shown to reduce bleeding and transfusion needs in patients with inherited bleeding disorders and in multiple surgical settings, evidence in therapy-induced thrombocytopenia in hematologic malignancy is lacking. The American Trial Using Tranexamic Acid (TXA) in Thrombocytopenia (A-TREAT) evaluated the effects of prop

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Sagatys, Elizabeth, Lynn Moscinski, Sophie Dessureault, Eduardo Sotomayor, and Hernani Cualing. "Analysis of T-Cell Subpopulations in the Lymph Nodes of Patients with Mantle Cell Lymphoma." Blood 110, no. 11 (2007): 1580. http://dx.doi.org/10.1182/blood.v110.11.1580.1580.

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Abstract Mantle cell lymphoma (MCL) is an aggressive and incurable B-cell NHL characterized by a high relapse rate. Novel treatments capable of providing and/or sustaining more durable responses in MCL patients are clearly needed. Manipulation of the immune system to unleash its protective effect might induce durable responses in MCL. To effectively harness the immune system against MCL, it is important to understand how T-cells interact with malignant B-cells that reside where immune responses are normally initiated. In the present study, we evaluated the number and phenotype of T-cells prese

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Hong, Dongzhe, Jerry Avorn, Richard Wyss, and Aaron S. Kesselheim. "Characteristics of Patients Receiving Novel Muscular Dystrophy Drugs in Trials vs Routine Care." JAMA Network Open 7, no. 1 (2024): e2353094. http://dx.doi.org/10.1001/jamanetworkopen.2023.53094.

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ImportanceThe US Food and Drug Administration approved eteplirsen for Duchenne muscular dystrophy (DMD) in 2016 based on a controversial pivotal study that demonstrated a limited effect on the surrogate measure of dystrophin production. Other DMD treatments in the same class followed.ObjectiveTo assess how patients receiving novel DMD treatments in postapproval clinical settings compare with patients in the clinical trials.Design, Setting, and ParticipantsThis cross-sectional study collected data on patients who initiated 1 of 4 novel DMD treatments (eteplirsen, golodirsen, viltolarsen, and ca

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Park, Jun-Gu, Seung-Beom Han, and Ki-Mo Jang. "Association of Preoperative Tibial Varus Deformity With Joint Line Orientation and Clinical Outcome After Open-Wedge High Tibial Osteotomy for Medial Compartment Osteoarthritis: A Propensity Score–Matched Analysis." American Journal of Sports Medicine 49, no. 13 (2021): 3551–60. http://dx.doi.org/10.1177/03635465211044146.

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Background: The correction of lower limb deformity should be performed at the site of deformity to maintain knee joint orientation. However, the effectiveness of open-wedge high tibial osteotomy (OWHTO) for treatment of medial osteoarthritis in varus malalignment without definite tibial varus deformity has not been confirmed. Purpose/Hypothesis: This study aimed to compare the clinical and radiologic outcomes after OWHTO in patients without tibial varus deformity versus patients with tibial varus deformity after matching for confounding factors. We hypothesized that these outcomes would be inf

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Stanosz, G., and D. Smith. "Sawadaea tulasnei Powdery Mildew of Norway Maple (Acer platanoides) in Oregon." Plant Disease 98, no. 2 (2014): 281. http://dx.doi.org/10.1094/pdis-06-13-0677-pdn.

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In August 2012, Norway maple ‘Crimson Century’ trees affected by powdery mildew were observed in Portland, OR. A majority of leaves throughout the crowns on each of the five trees planted in the street terrace on one side of a single city block were affected. White mycelium was present in irregular, discrete, scattered spots or almost continuously on the upper surfaces of leaves and also was present on some petioles. The affected area of the upper surface of leaf blades was estimated to typically be >50%. Chasmothecia were present singly or in groups on the mycelium, and bore simple and bif

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