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Journal articles on the topic '+ 34.02 (043.2)'

Author: Grafiati

Published: 30 May 2022

Last updated: 31 July 2025

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1

Sun, Sam Q., Chunyu Cai, Rory K. J. Murphy, et al. "Management of Atypical Cranial Meningiomas, Part 2." Neurosurgery 75, no. 4 (2014): 356–63. http://dx.doi.org/10.1227/neu.0000000000000462.

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Abstract BACKGROUND: The efficacies of adjuvant stereotactic radiosurgery (SRS) and external beam radiation therapy (EBRT) for atypical meningiomas (AMs) after subtotal resection (STR) remain unclear. OBJECTIVE: To analyze the clinical, histopathological, and radiographic features associated with progression in AM patients after STR. METHODS: Fifty-nine primary AMs after STR were examined for predictors of progression, including the impact of SRS and EBRT, in a retrospective cohort study. RESULTS: Twenty-seven patients (46%) progressed after STR (median, 30 months). On univariate analysis, spo

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Friedman, Julia, Kathryn Vannatta, William A. Cunningham, Elisabeth A. Wilde, Keith Owen Yates, and Kristen R. Hoskinson. "34 Severity of Traumatic Brain Injury Predicts Neurobehavioral Outcomes and White Matter Microstructure." Journal of the International Neuropsychological Society 29, s1 (2023): 142–43. http://dx.doi.org/10.1017/s1355617723002382.

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Objective:Pediatric traumatic brain injury (TBI) is the leading cause of disability in children under the age of 15, often resulting in executive function deficits and poor behavioral outcomes. Damage to white matter tracts may be a driving force behind these difficulties. We examined if whether 1) greater TBI severity was associated with worse neurobehavioral outcome, 2) greater TBI severity was associated with tract-based white matter microstructure, and 3) worse neurobehavioral outcome was associated with white matter microstructure.Participants and Methods:Twelve children with complicated-

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Rachmayati, Rike, Eva Agustriana, and Delicia Yunita Rahman. "UV Mutagenesis as a Strategy to Enhance Growth and Lipid Productivity of Chlorella sp. 042." Journal of Tropical Biodiversity and Biotechnology 5, no. 3 (2020): 218. http://dx.doi.org/10.22146/jtbb.56862.

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Microalgae appeared to be an alternative feedstock for renewable biodiesel production due to their capability to accumulate considerable amounts of lipids. In this study, mutagenesis using UVC light with different periods was applied to Chlorella sp. 042 to produce a microalgae strain with high lipid productivity of 45, 60, and 75 min. The Nile red fluorescence method was conducted to select a Chlorella sp. mutant with high neutral lipid and generated one mutant from every UV mutation period, M45-06, M60-02, and M75-21. All of the mutants have higher growth rates than the wild type. Chlorella

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Luchko, Yosyp Y., Ihor I. Karkhut, and Markiian V. Mazepa. "RESTORATION OF SUPPORT PARTS OF EXTERNAL WALL PANELS SERIES IIS-04-2 TAKING INTO ACCOUNT SEISMIC LOADS OF 7 POINTS." Modern technology, materials and design in construction 35, no. 2 (2023): 26–34. http://dx.doi.org/10.31649/2311-1429-2023-2-26-34.

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This paper presents the results of the study of the strength of the junctions of external wall panels and columns and crossbars and columns of the IIS-03-02 series, which was used in the construction of the building of the Faculty of Biology of the Uzhgorod State University in the city of Uzhhorod. The survey and research data, as well as the development of recommendations, which were carried out by the employees of the Physico-Mechanical Institute named after G.V. Karpenka of the National Academy of Sciences on the order of «Zakarpatzalizoboton» VO from July 19, 1991. The work describes basic

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Kröger, Nicolaus, Ernst Holler, Guido Kobbe, et al. "Allogeneic stem cell transplantation after reduced-intensity conditioning in patients with myelofibrosis: a prospective, multicenter study of the Chronic Leukemia Working Party of the European Group for Blood and Marrow Transplantation." Blood 114, no. 26 (2009): 5264–70. http://dx.doi.org/10.1182/blood-2009-07-234880.

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Abstract From 2002 to 2007, 103 patients with primary myelofibrosis or postessential thrombocythemia and polycythemia vera myelofibrosis and a median age of 55 years (range, 32-68 years) were included in a prospective multicenter phase 2 trial to determine efficacy of a busulfan (10 mg/kg)/fludarabine (180 mg/m2)–based reduced-intensity conditioning regimen followed by allogeneic stem cell transplantation from related (n = 33) or unrelated donors (n = 70). All but 2 patients (2%) showed leukocyte and platelet engraftment after a median of 18 and 22 days, respectively. Acute graft-versus-host d

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Parashar, Vartika, Gail Koshorek, Thomas Roth, and Timothy Roehrs. "0463 Sleep Assessed by Actigraphy during Discontinuation of Chronic Hypnotic Use." Sleep 45, Supplement_1 (2022): A205. http://dx.doi.org/10.1093/sleep/zsac079.460.

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Abstract Introduction Inability to discontinue chronic hypnotic use by people with insomnia remains a clinical problem. Sleep was recorded by actigraphy during a two-week discontinuation in an on-going “blinded” clinical trial in which people with insomnia were instructed to discontinue their study medication after 6 months of nightly use. Methods DSM-V diagnosed people with insomnia (n=39, 34 females), aged 26-61 yrs, with no other sleep disorders, unstable medical or psychiatric diseases or drug dependency completed the clinical trial. Participants were randomized to zolpidem XR (12.5 mg), e

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Li, Molly SC, Alvin HK Cheung, Zeta Mui, et al. "Association of human leukocyte antigen (HLA) status with immune checkpoint inhibitor (ICI) pneumonitis in patients with non-small cell lung cancer (NSCLC)." Journal of Clinical Oncology 42, no. 16_suppl (2024): 8620. http://dx.doi.org/10.1200/jco.2024.42.16_suppl.8620.

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8620 Background: Pneumonitis is a potentially serious complication occurring in 5-20% of lung cancer patients receiving ICI. The genetic risk factors for ICI pneumonitis are unclear. Given the association between HLA genetic variants and autoimmune diseases, we hypothesized that certain HLA genetic variants are associated with risk of ICI pneumonitis. Methods: Patients with advanced EGFR/ ALK wild type, PD-L1 tumor proportion score ≥50% NSCLC who received ICI were enrolled from year 2019 to 2022. Germline HLA typing was performed on buccal swab specimens using the Alltype Fastplex assay. Clini

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Ghosh, Joydeep, Sandip Ganguly, Debapriya Mondal, Prashant Pandey, Deepak Dabkara, and Bivas Biswas. "Perspective of Oncology Patients During COVID-19 Pandemic: A Prospective Observational Study From India." JCO Global Oncology, no. 6 (September 2020): 844–51. http://dx.doi.org/10.1200/go.20.00172.

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PURPOSE The coronavirus disease 2019 (COVID-19) pandemic has imposed a unique challenge to oncology patients and their treatment. There is no study related to the patients’ preference for systemic therapy during this pandemic. We have conducted a prospective study to analyze that aspect. METHODS All consecutive patients who visited during the lockdown period from April 1-10, 2020, for systemic chemotherapy were included in the study for a questionnaire-based survey to evaluate the willingness to continue chemotherapy during this pandemic and factors influencing the decisions. RESULTS A total o

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Rahmaningtyas, Hardianika, Joko Sulianto, and Ngatmini. "Analisis Keterampilan Koneksi Matematis Pada Permainan Marching Bell Kelas B TK Aisyiyah Bustanul Athfal 02 Todanan Kecamatan Todanan Kabupaten Blora Semester Gasal Tahun Ajaran 2024/2025." Edukatika 2, no. 2 (2024): 39–49. https://doi.org/10.26877/edukatika.v2i2.1488.

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Penelitian ini bertujuan untuk: (1) mengetahui apakah permainan marching bell meningkatkan Keterampilan Koneksi Matematis, (2) mengetahui efektivitas permainan marching bell terhadap Koneksi Matematis. Jenis penelitian ini adalah penelitian Quasi Eksprimental Design. Adapun bentuk desain quasi eksperimen yang digunakan adalah Nonequivalent Control Group Design. Populasi dan sampel pada penelitian ini adalah anak kelompok B di TK Aisiyah Bustanul Athfal 02 Todanan Kabupaten Blora Semester II Tahun Pelajaran 2024/2025 berjumlah 18. Analisis data meliputi langkah-langkah sebagai berikut: (1) uji

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Sevilla-Gonzalez, Magdalena Del Rocio, Brigette Bourguet-Ramirez, Laura Sofia Lazaro-Carrera, Alexandro J. Martagon-Rosado, Donaji Veronica Gomez-Velasco, and Tannia Leticia Viveros-Ruiz. "Evaluation of a Web Platform to Record Lifestyle Habits in Subjects at Risk of Developing Type 2 Diabetes in a Middle-Income Population: Prospective Interventional Study." JMIR Diabetes 7, no. 1 (2022): e25105. http://dx.doi.org/10.2196/25105.

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Background Lifestyle is the focus of type 2 diabetes (T2D) prevention strategies. Prevention strategies using mobile health (mHealth)–based therapy have shown positive results for T2D prevention in high-income settings, but little is known about their effectiveness in low- and middle-income populations where the burden of T2D is substantial. “Vida Sana” is a web platform designed to record lifestyle habits and medication use within a lifestyle change program. Objective We sought to identify the barriers, feasibility, usability, and effectiveness of Vida Sana to record lifestyle habits in subje

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Pardanani, Animesh, Ken-Hong Lim, Terra L. Lasho, et al. "Prognostically relevant breakdown of 123 patients with systemic mastocytosis associated with other myeloid malignancies." Blood 114, no. 18 (2009): 3769–72. http://dx.doi.org/10.1182/blood-2009-05-220145.

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Abstract The prognostic heterogeneity of the World Health Organization category of “systemic mastocytosis with associated clonal hematologic nonmast cell lineage disease” (SM-AHNMD) has not been systematically validated by primary data. Among 138 consecutive cases with SM-AHNMD, 123 (89%) had associated myeloid neoplasm: 55 (45%) myeloproliferative neoplasm (SM-MPN), 36 (29%) chronic myelomonocytic leukemia, 28 (23%) myelodysplastic syndrome (SM-MDS), and 4 (3%) acute leukemia. Of the myeloid subgroups, SM-MPN displayed a 2- to 3-fold better life expectancy (P = .003), whereas leukemic transfo

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Nagler, Arnon, Myriam Labopin, Bhagirathbhai Dholaria, et al. "Impact of antithymocyte globulin on outcomes of allogeneic hematopoietic cell transplantation with TBI." Blood Advances 3, no. 13 (2019): 1950–60. http://dx.doi.org/10.1182/bloodadvances.2019000030.

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Abstract The impact of the use of antithymocyte globulin (ATG) following a total body irradiation (TBI)–based myeloablative conditioning regimen has been poorly explored. We retrospectively analyzed 724 patients who underwent a first allogeneic hematopoietic cell transplantation (allo-HCT) following a TBI-based conditioning regimen for acute myeloid leukemia (AML) and compared the outcomes of 251 (35%) patients who received ATG (ATG group) with 473 (65%) patients who did not (non-ATG group). Median follow-up of surviving patients was 59 months (interquartile range, 28-83). The cumulative incid

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CRAINE, N., M. HICKMAN, J. V. PARRY, et al. "Incidence of hepatitis C in drug injectors: the role of homelessness, opiate substitution treatment, equipment sharing, and community size." Epidemiology and Infection 137, no. 9 (2009): 1255–65. http://dx.doi.org/10.1017/s095026880900212x.

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SUMMARYA prospective cohort study estimated the incidence of hepatitis C virus (HCV) in drug injectors in South Wales (UK). In total, 286/481 eligible seronegative individuals were followed up after approximately 12 months. Dried blood spot samples were collected and tested for anti-HCV antibody and behavioural data were collected at baseline and follow-up. HCV incidence was 5·9/100 person-years [95% confidence interval (CI) 3·4–9·5]. HCV incidence was predicted by community size [incident rate ratio (IRR) 6·6, 95% CI 2·11–20·51,P=0·001], homelessness (IRR 2·9, 95% CI 1·02–8·28,P=0·047) and sh

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Kampf, Anthony R., Jakub Plášil, Barbara P. Nash, Ivan Němec, and Joe Marty. "Uroxite and metauroxite, the first two uranyl oxalate minerals." Mineralogical Magazine 84, no. 1 (2019): 131–41. http://dx.doi.org/10.1180/mgm.2019.57.

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AbstractUroxite (IMA2018-100), [(UO2)2(C2O4)(OH)2(H2O)2]⋅H2O, and metauroxite (IMA2019-030), (UO2)2(C2O4)(OH)2(H2O)2, are the first two uranyl oxalate minerals. Uroxite was found in the Markey mine, Red Canyon, San Juan County, Utah, USA and in the Burro mine, Slick Rock district, San Miguel County, Colorado, USA. Metauroxite was found only in the Burro mine. Both minerals are post-mining secondary phases found in efflorescent crusts on mine walls. Uroxite occurs as light yellow striated blades exhibiting moderate neon-green fluorescence, ca 2 Mohs hardness with good {101} and {010} cleavages.

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Claviez, Alexander, Hartmut Kabisch, Meinolf Suttorp, et al. "The Impact of Disease Status at Transplant and Time to First Relapse on Outcome in Children and Adolescents with Hodgkin’s Lymphoma Undergoing Autologous Stem Cell Transplantation." Blood 104, no. 11 (2004): 1878. http://dx.doi.org/10.1182/blood.v104.11.1878.1878.

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Abstract The prognosis of Hodgkin’s lymphoma (HL) in pediatric patients (pts) with current combined chemoradiotherapy regimens in general is excellent. Even those pts suffering from recurrent disease have a realistic chance for cure with salvage therapy regimens. 74 patients (<18 years at diagnosis; 69% male; 76% nodular sclerosis) mainly treated according to pediatric DAL or GPOH protocols received an autologous stem cell transplantation (ASCT) for recurrent or refractory disease between 1987 and 2003. 28 pts had progressive disease (PD, <3 months following the end of therapy), 34 had a

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Marsh, Judith C., Andrea Bacigalupo, Hubert Schrezenmeier, et al. "Prospective study of rabbit antithymocyte globulin and cyclosporine for aplastic anemia from the EBMT Severe Aplastic Anaemia Working Party." Blood 119, no. 23 (2012): 5391–96. http://dx.doi.org/10.1182/blood-2012-02-407684.

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Abstract Rabbit antithymocyte globulin (rATG; thymoglobulin, Genzyme) in combination with cyclosporine, as first-line immunosuppressive therapy, was evaluated prospectively in a multicenter, European, phase 2 pilot study, in 35 patients with aplastic anemia. Results were compared with 105 age- and disease severity–matched patients from the European Blood and Marrow Transplant registry, treated with horse ATG (hATG; lymphoglobulin) and cyclosporine. The primary end point was response at 6 months. At 3 months, no patients had achieved a complete response to rATG. Partial response occurred in 11

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Jahanian, Omid, Meegan G. Van Straaten, Brianna M. Goodwin, et al. "Inertial Measurement Unit–Derived Ergonomic Metrics for Assessing Arm Use in Manual Wheelchair Users With Spinal Cord Injury: A Preliminary Report." Topics in Spinal Cord Injury Rehabilitation 27, no. 3 (2021): 12–25. http://dx.doi.org/10.46292/sci20-00059.

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Background: Individuals with spinal cord injury (SCI) who use manual wheelchairs (MWCs) have a higher rate of rotator cuff pathology progression than able-bodied individuals. Objectives: This study aimed to test the ability of risk and recovery metrics of arm use to differentiate between (1) MWC users with SCI and matched able-bodied participants (cross-sectional matched-sample study) and (2) MWC users with rotator cuff pathology progression over 1 year from those without pathology progression (longitudinal study). Methods: Thirty-four MWC users and 34 age- and sex-matched able-bodied individu

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Ortiz, Johana, John Van Camp, Sylviana Wijaya, Silvana Donoso, and Lieven Huybregts. "Determinants of child malnutrition in rural and urban Ecuadorian highlands." Public Health Nutrition 17, no. 9 (2013): 2122–30. http://dx.doi.org/10.1017/s1368980013002528.

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AbstractObjectiveTo identify and compare the sociodemographic determinants of stunting, wasting and overweight among infants of urban and rural areas in the Ecuadorian highlands.DesignCross-sectional study.SettingNabon (rural) and Cuenca (urban) cantons, Azuay Province, Ecuador.SubjectsA total of 703 children aged 0–24 months and their caregivers (227 rural and 476 urban) recruited during the period from June to September 2008.ResultsStunting prevalence was significantly higher in the rural area (37·4 %v. 17·7 %;P< 0·001) while wasting (7·1 %) and overweight (17·1 %) prevalence were more si

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Shab-Bidar, Sakineh, Tirang R. Neyestani, and Abolghassem Djazayery. "Vitamin D receptor Cdx-2-dependent response of central obesity to vitamin D intake in the subjects with type 2 diabetes: a randomised clinical trial." British Journal of Nutrition 114, no. 9 (2015): 1375–84. http://dx.doi.org/10.1017/s0007114515003049.

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AbstractThis study aimed to investigate the effects of daily intake of vitamin D-fortified yogurt drink (doogh) on central obesity indicators in subjects with type 2 diabetes (T2D) and the possible modulation of this effect by vitamin D receptor (VDR) Cdx-2 genotypes. A total of sixty T2D subjects were randomly allocated to two groups to receive either plain doogh (PD; n 29, containing 170 mg Ca and no vitamin D/250 ml) or vitamin D3-fortified doogh (FD; n 31, containing 170 mg Ca and 12·5 μg/250 ml) twice a day for 12 weeks. 25-hydroxyvitamin D (25(OH)D), glycaemic as well as adiposity indica

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Tsimberidou, Apostolia-Maria, Susan O'Brien, Issa Khouri, et al. "Clinical Outcomes and Prognostic Factors in Patients With Richter's Syndrome Treated With Chemotherapy or Chemoimmunotherapy With or Without Stem-Cell Transplantation." Journal of Clinical Oncology 24, no. 15 (2006): 2343–51. http://dx.doi.org/10.1200/jco.2005.05.0187.

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Purpose The purpose of this study was to assess the incidence, presenting characteristics, and treatment outcomes of Richter's syndrome (RS) and factors predicting response and survival. Patients and Methods An electronic database search of patients with chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL) who presented at The University of Texas M.D. Anderson Cancer Center (Houston, TX) between January 1975 and June 2005 was performed, and patient medical records were reviewed. Results Of the 3,986 patients with CLL/SLL, 204 patients (5.1%) had possible RS, and 148 patients (3.

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Mortimer, Joanne E., Leslie Boucher, Jack Baty, Diana L. Knapp, Elizabeth Ryan, and Julia H. Rowland. "Effect of Tamoxifen on Sexual Functioning in Patients With Breast Cancer." Journal of Clinical Oncology 17, no. 5 (1999): 1488. http://dx.doi.org/10.1200/jco.1999.17.5.1488.

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PURPOSE: To define the incidence of sexual dysfunction in a population of women with breast cancer treated with tamoxifen. PATIENTS AND METHODS: Breast cancer patients with a performance status of 0 to 2 who had been treated with tamoxifen for 2 to 24 months completed the following measures: the Center for Epidemiologic Studies–Depression Scale, the Sexual History Form, and the Breast Cancer Prevention Trial Symptom Checklist. Forty-nine of the participants underwent gynecologic examinations with vaginal smears for determination of estrogen effect. RESULTS: Fifty-seven women were entered onto

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Philips, Kamaira Hartley, Carrie E. Brintz, Kevin Moss, and Susan A. Gaylord. "Didgeridoo Sound Meditation for Stress Reduction and Mood Enhancement in Undergraduates: A Randomized Controlled Trial." Global Advances in Health and Medicine 8 (January 2019): 216495611987936. http://dx.doi.org/10.1177/2164956119879367.

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Background College students report feeling frequently stressed, which adversely impacts health. Meditation is one effective method for reducing stress, but program length and required effort are potential obstacles. Research on sound meditation, involving focused listening to sounds, is nascent but may appeal to undergraduates. The effects of listening to didgeridoo, an Australian wind instrument producing a low, resonant, droning sound, have not been studied. Objective This study compared the effect of a 30-minute didgeridoo sound meditation versus silent meditation with focus on one’s breath

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West, Caroline, Timothy Maul, Brian Feingold, and Victor O. Morell. "Right Ventricular Dominance Is Associated With Inferior Outcomes After the Extracardiac Fontan." World Journal for Pediatric and Congenital Heart Surgery 10, no. 4 (2019): 416–23. http://dx.doi.org/10.1177/2150135119843887.

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Background: Investigations of ventricular dominance and outcomes after the Fontan procedure have shown conflicting results. This may be due to the inclusion of multiple modifications of the Fontan or the omission of recently identified complications of the procedure. We examined the association between right ventricular dominance (RVD) and morbidity/mortality in a contemporary cohort following the extracardiac (EC) Fontan. Methods: We studied all pediatric patients at our center who underwent a predominantly fenestrated EC Fontan from 2004 to 2016. Outcomes assessed were freedom from (1) Fonta

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Greenberg, Spencer, Danielle Brand, Aislinn Pluta, Douglas Moore, and Kirsten DeConti. "Nudging Resisters Toward Change: Self-Persuasion Interventions for Reducing Attitude Certainty." American Journal of Health Promotion 32, no. 4 (2017): 997–1009. http://dx.doi.org/10.1177/0890117117715295.

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Purpose: To identify effective self-persuasion protocols that could easily be adapted to face-to-face clinical sessions or health-related computer applications as a first step in breaking patient resistance. Design: Two self-persuasion interventions were tested against 2 controls in a between-subject randomized control experiment. Setting: GuidedTrack—a web-based platform for social science experiments. Participants: Six hundred seventeen adult participants recruited via Mechanical Turk. Intervention: The experimental interventions prompted participants for self-referenced pro- and counteratti

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Yang, Luxi, Le Shu, Junyi Jiang, et al. "Long-term effect of dietary fibre intake on glycosylated haemoglobin A1c level and glycaemic control status among Chinese patients with type 2 diabetes mellitus." Public Health Nutrition 17, no. 8 (2013): 1858–64. http://dx.doi.org/10.1017/s1368980013002000.

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AbstractObjectiveDietary fibre has been linked to lower levels of glycosylated haemoglobin A1c (HbA1c) among diabetes patients. The present study aimed to evaluate the long-term effect of dietary fibre on HbA1c levels among Chinese patients with type 2 diabetes mellitus.DesignTwo cross-sectional surveys were conducted in 2006 and 2011, with the second one being a repeat survey on a sub-sample from the initial one. In both surveys, an in-person interview was conducted to collect information on demographic characteristics and lifestyles following a similar protocol. Dietary intake was assessed w

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GOKA, E. A., P. J. VALLELY, K. J. MUTTON, and P. E. KLAPPER. "Single, dual and multiple respiratory virus infections and risk of hospitalization and mortality." Epidemiology and Infection 143, no. 1 (2014): 37–47. http://dx.doi.org/10.1017/s0950268814000302.

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SUMMARYRespiratory virus infections cause a significant number of hospitalization and deaths globally. This study investigated the association between single and multiple respiratory virus infections and risk of admission to a general ward, intensive care unit or death in patients aged 0–105 years (mean ± s.d. = 24·4 ± 24·1 years), from North West England, that were tested for respiratory virus infections between January 2007 and June 2012. The majority of infections were in children aged ⩽5 years. Dual or multiple infections occurred in 10·4% (1214/11 715) of patients, whereas single infectio

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Thavaraputta, Subhanudh, Hussain Mahmud, Anamil Khiyami, Georgios Zenonos, Paul Gardner, and Pouneh Fazeli. "ODP369 Weight Trajectory as a Predictor of Cushing's Disease." Journal of the Endocrine Society 6, Supplement_1 (2022): A517—A518. http://dx.doi.org/10.1210/jendso/bvac150.1076.

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Abstract Cushing's syndrome, a disorder of cortisol excess, is associated with significant morbidity and mortality. Obesity, hypertension and glucose intolerance are common clinical findings in patients with Cushing's, but with the increasing incidence of obesity worldwide-- nearly 40% of the world's adult population is currently overweight– and the increasing incidence of obesity-associated comorbidities of hypertension and diabetes mellitus, deciding whom to screen for Cushing's can be very challenging and frequently delays timely diagnosis. We performed a retrospective study in patients wit

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Al-Kaisey, Ahmed M., Ramanathan Parameswaran, Christina Bryant, et al. "Atrial Fibrillation Catheter Ablation vs Medical Therapy and Psychological Distress." JAMA 330, no. 10 (2023): 925. http://dx.doi.org/10.1001/jama.2023.14685.

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ImportanceThe impact of atrial fibrillation (AF) catheter ablation on mental health outcomes is not well understood.ObjectiveTo determine whether AF catheter ablation is associated with greater improvements in markers of psychological distress compared with medical therapy alone.Design, Setting, and ParticipantsThe Randomized Evaluation of the Impact of Catheter Ablation on Psychological Distress in Atrial Fibrillation (REMEDIAL) study was a randomized trial of symptomatic participants conducted in 2 AF centers in Australia between June 2018 and March 2021.InterventionsParticipants were random

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Tomoda, T., M. Arimoto, T. Mizuno, et al. "Multi-pixel photon counter-based gamma camera with pinhole collimator to locate Cs-137 sources at high dose rates for the Fukushima nuclear power plant." Journal of Instrumentation 19, no. 02 (2024): C02032. http://dx.doi.org/10.1088/1748-0221/19/02/c02032.

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Abstract The Fukushima Daiichi Nuclear Power Plant was severely damaged during the 2011 Great East Japan Earthquake. However, the ongoing decommissioning work has been limited by the complexity of the reactor's internal structure and very high radiation levels; locating radioactive sources is essential for efficient decommissioning. Conventional gamma cameras are mainly designed for low radiation dose (∼mSv/h) and using them under high radiation conditions is difficult (>Sv/h). Therefore, we developed a pinhole gamma camera with a gamma radiation detector consisting of a high-speed YGAG sci

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Iwasa, Satoru, Hiroya Taniguchi, Kentaro Yamazaki, et al. "Phase 1 trial of OCV-C02, a peptide vaccine for metastatic colorectal cancer patients refractory to all standard chemotherapies." Journal of Clinical Oncology 35, no. 4_suppl (2017): 706. http://dx.doi.org/10.1200/jco.2017.35.4_suppl.706.

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706 Background: OCV-C02 is a peptide vaccine consisting of 2 peptide epitopes derived from ring finger protein 43 and translocase of outer mitochondrial membrane 34. In colorectal cancer (CRC), they are upregulated in approximately 80% of tumor tissues. This study was conducted to assess safety, preliminary efficacy and immunological responses to OCV-C02. Methods: Key eligibility criteria for this open label, sequential cohort, dose escalation study were patients (pts) with unresectable metastatic CRC (mCRC) refractory to all standard chemotherapies and HLA-A*24:02. Pts in cohorts 1 to 4 recei

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Friedman, James M., Favian Su, Alan L. Zhang, et al. "Patient-Reported Activity Levels Correlate With Early Cartilage Degeneration After Anterior Cruciate Ligament Reconstruction." American Journal of Sports Medicine 49, no. 2 (2021): 442–49. http://dx.doi.org/10.1177/0363546520980431.

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Background: The association between activity level after anterior cruciate ligament (ACL) reconstruction (ACLR) and development of posttraumatic osteoarthritis (PTOA) remains unclear. This study investigated the relationship of patient-reported outcomes and progressive cartilage degenerative changes at 3 years after ACLR. Hypothesis: Higher activity levels, as measured by Marx scores, are significantly correlated with early cartilage degeneration after ACLR. Study Design: Cohort study; Level of evidence, 2. Methods: A total of 35 patients (16 women; mean age, 31.0 ± 7.6 years) with isolated AC

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Nakauth, A. C. S. Sampaio, M. A. Villacorta-Correa, M. R. Figueiredo, G. Bernardino, and J. M. França. "Embryonic and larval development of Brycon amazonicus (SPIX & AGASSIZ, 1829)." Brazilian Journal of Biology 76, no. 1 (2016): 109–16. http://dx.doi.org/10.1590/1519-6984.13914.

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Abstract The objective of this study was to describe the embryonic and larval development of Brycon amazonicus, featuring the main events up to 50 hours after fertilization (AF). The material was provided by the Aquaculture Training, Technology and Production Center, Presidente Figueiredo (AM). The characterization was based on stereomicroscopic examination of the morphology of eggs, embryos and larvae and comparison with the literature. Matrinxã eggs are free, transparent, and spherical, with a perivitelline space of 0.56 ± 0.3 mm. The successive divisions give rise to cells with 64 blastomer

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Saunders, Philo U., Christoph Ahlgrim, Brent Vallance, et al. "An Attempt to Quantify the Placebo Effect From a Three-Week Simulated Altitude Training Camp in Elite Race Walkers." International Journal of Sports Physiology and Performance 5, no. 4 (2010): 521–34. http://dx.doi.org/10.1123/ijspp.5.4.521.

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Purpose:To quantify physiological and performance effects of hypoxic exposure, a training camp, the placebo effect, and a combination of these factors.Methods:Elite Australian and International race walkers (n = 17) were recruited, including men and women. Three groups were assigned: 1) Live High:Train Low (LHTL, n = 6) of 14 h/d at 3000 m simulated altitude; 2) Placebo (n = 6) of 14 h/d of normoxic exposure (600 m); and 3) Nocebo (n = 5) living in normoxia. All groups undertook similar training during the intervention. Physiological and performance measures included 10-min maximal treadmill d

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Mehta, Sanjay Kumar, Madineni Venkat Ratnam, Sukumarapillai V. Sunilkumar, Daggumati Narayana Rao, and Boddapaty V. Krishna Murthy. "Diurnal variability of the atmospheric boundary layer height over a tropical station in the Indian monsoon region." Atmospheric Chemistry and Physics 17, no. 1 (2017): 531–49. http://dx.doi.org/10.5194/acp-17-531-2017.

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Abstract. The diurnal variation of atmospheric boundary layer (ABL) height is studied using high-resolution radiosonde observations available at 3 h intervals for 3 days continuously from 34 intensive campaigns conducted during the period December 2010–March 2014 over a tropical station Gadanki (13.5° N, 79.2° E; 375 m), in the Indian monsoon region. The heights of the ABL during the different stages of its diurnal evolution, namely, the convective boundary layer (CBL), the stable boundary layer (SBL), and the residual layer (RL) are obtained to study the diurnal variabilities. A clear diurnal

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Newbold, J. R., P. C. Garnsworthy, P. J. Buttery, D. J. A. Cole та W. Haresign. "Responses of British Friesian steers with or without implants of oestradiol-17β to undegradable dietary protein". Animal Science 46, № 2 (1988): 181–93. http://dx.doi.org/10.1017/s0003356100042239.

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AbstractThe ability of the protein nutrition scheme proposed by the Agricultural Research Council (ARC, 1980, 1984) to predict responses to protein supply was examined in two experiments. In experiment 1, groups of nine British Friesian steers implanted with oestradiol-17β and nine non-implanted steers were fed from 133 to 300 kg live weight on each of four all-concentrate diets (metabolizable energy (ME) = 12 MJ/kg dry matter (DM)) containing ratios of soya-bean meal and formaldehyde-treated soya-bean meal such that undegradable protein (UDP) concentration was 19, 25, 32 or 42 g/kg DM. Rumen

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Gimranov, D. O., P. A. Kosintsev, O. P. Bachura, M. G. Zhilin, V. G. Kotov, and M. M. Rumyantsev. "Small cave bear (U. ex gr. savini-rossicus) as a game species of prehistoric man." VESTNIK ARHEOLOGII, ANTROPOLOGII I ETNOGRAFII, no. 2(53) (May 28, 2021): 5–14. http://dx.doi.org/10.20874/2071-0437-2021-53-2-1.

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Imanay Cave is located in the Southern Urals (53°02' N, 56°26' E), at 420 m.a.s.l. A 9.5 m2 trench was exca-vated in the grotto in the inner part of the cave to examine the sediments. The accretion thickness was 1.2 m. The taphocoenosis of the Imanay Cave is of the Pleistocene age and contains about 10,000 specimens of bone re-mains of large mammals. They mostly belong to small cave bear (U. ex gr. savini-rossicus), and the remaining bones — to species of the mammoth faunal complex (Lepus sp., Castor fiber, Marmota bobak, Canis lupus, Cuon alpinus, Vulpes vulpes, V. corsac, Meles sp., Gulo gul

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Rodriguez, Cristina P., Sylvia Lee, Graham Watson, et al. "Phase 2 open-label study of brentuximab vedotin (BV) + pembrolizumab (pembro) in patients (pts) with treatment (tx)-naive metastatic head and neck squamous cell carcinoma (HNSCC)." Journal of Clinical Oncology 43, no. 16_suppl (2025): 6015. https://doi.org/10.1200/jco.2025.43.16_suppl.6015.

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6015 Background: BV, an antibody-drug conjugate (ADC) targeting CD30, is hypothesized to deplete T regulatory cells (Tregs) that express CD30 and resensitize tumors to anti–PD-1 therapy. SGN35-033 (NCT04609566) is an ongoing multicohort study evaluating the efficacy and safety of BV + pembro in pts with solid tumors; we report results for cohort 6 in tx-naive HNSCC with PD-L1 combined positive score (CPS) ≥1, where pembro has historically demonstrated ORR of 19% and mPFS of 3.2 months. Methods: Cohort 6 included pts with metastatic HNSCC with PD-L1 CPS ≥1 by local testing and no prior therapy

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Zangari, Maurizio, Bart Barlogie, Klaus Hollmig, et al. "Marked Activity of Velcade Plus Thalidomide (V+T) in Advanced and Refractory Multiple Myeloma (MM)." Blood 104, no. 11 (2004): 1480. http://dx.doi.org/10.1182/blood.v104.11.1480.1480.

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Abstract Based on an index patient who responded to V 1.0 mg/m2 + T 100 mg upon progression on V alone and documented prior resistance to T, a phase 1–2 trial was initiated of the V+T combination in patients with advanced and refractory MM, 79% with a history of cytogenetic abnormalities (CA) including 57% pre-V, 81% with one and 52% with 2 prior transplants (n=79). Due to concerns for synergistic neurotoxicity, V was initially given at a dose of 1.0 mg/m2 on days 1, 4, 8 and 11; with the second cycle on day 21, T was introduced at incremental doses, per cohorts of at least 10 patients, at 50,

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Alter, Thomas D., Derrick M. Knapik, Floor Lambers, et al. "Sex-Based Differences in Femoroacetabular Impingement Syndrome and the Effect of Cam Deformity Location on the Extent of Labral Tearing: A 3-Dimensional Computed Tomography Study." Orthopaedic Journal of Sports Medicine 10, no. 5 (2022): 232596712210951. http://dx.doi.org/10.1177/23259671221095174.

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Background: Sex-specific quantification of cam morphology in patients with femoroacetabular impingement syndrome may improve diagnostics, surgical planning, and outcomes. Purpose: To (1) examine differences between men and women with symptomatic cam deformities based on deformity location, magnitude, and extent; (2) assess the association between cam deformity and labral pathology; and (3) evaluate the relationship between cam deformity and patient-reported outcome measures after hip arthroscopy. Study Design: Cohort study; Level of evidence, 3. Methods: Computed tomography (CT) scans were acq

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Malloy, Philip, Daniel M. Wichman, Flavio Garcia, Alejandro Espinoza-Orías, Jorge Chahla, and Shane J. Nho. "Impaired Lower Extremity Biomechanics, Hip External Rotation Muscle Weakness, and Proximal Femoral Morphology Predict Impaired Single-Leg Squat Performance in People With FAI Syndrome." American Journal of Sports Medicine 49, no. 11 (2021): 2984–93. http://dx.doi.org/10.1177/03635465211029032.

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Background: Impairments in squat depth have been reported in patients with femoroacetabular impingement syndrome (FAIS). However, little is known about single-leg squat (SLS) performance in these patients, despite this task being commonly used in the rehabilitation and training settings. Purpose/Hypothesis: The aims of this study were (1) to investigate whether patients with FAIS demonstrate differences in SLS performance compared with healthy controls and (2) to determine whether dynamic range of motion (ROM), muscle strength, hip morphologic measures, hip pain, and hip-specific function pred

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Zhang, Xiaotong, Jue Liu, Na Han, and Jing Yin. "Social Media Use, Unhealthy Lifestyles, and the Risk of Miscarriage Among Pregnant Women During the COVID-19 Pandemic: Prospective Observational Study." JMIR Public Health and Surveillance 7, no. 1 (2021): e25241. http://dx.doi.org/10.2196/25241.

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Background The COVID-19 pandemic has resulted in changes to normal life and disrupted social and economic function worldwide. However, little is known about the impact of social media use, unhealthy lifestyles, and the risk of miscarriage among pregnant women during the COVID-19 pandemic. Objective This study aims to assess the association between social media use, unhealthy lifestyles, and the risk of miscarriage among pregnant women in the early stage of the COVID-19 pandemic in China. Methods In this prospective cohort study, 456 singleton pregnant women in mainland China were recruited dur

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Jentzsch, Madlen, Marius Bill, Julia Schulz, et al. "High Blood BAALC Copy Numbers Determined By Digital Droplet PCR at Timepoint of Allogeneic Transplantation in Complete Remission Predicts Relapse in Patients with Acute Myeloid Leukemia." Blood 128, no. 22 (2016): 517. http://dx.doi.org/10.1182/blood.v128.22.517.517.

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Abstract Allogeneic hematopoietic cell transplantation (HSCT) is a powerful consolidation option for acute myeloid leukemia (AML) patients (pts) in hematologic complete remission (CR). Disease recurrence after HSCT remains a major clinical problem & early identification of AML pts at risk of relapse is crucial to improve outcomes. High expression of the AML associated gene BAALC (Brain and acute leukemia, cytoplasmic) at diagnosis adversely impacts on outcomes in AML pts. Little is known about its prognostic capacity during disease course & as a marker of residual disease. Here we adop

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Baron, Frederic, Michael B. Maris, Brenda M. Sandmaier, et al. "Graft-versus-Tumor Effects after Allogeneic Hematopoietic Cell Transplantation with Nonmyeloablative Conditioning." Blood 104, no. 11 (2004): 184. http://dx.doi.org/10.1182/blood.v104.11.184.184.

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Abstract We have used a nonmyeloablative conditioning regimen consisting of 2 Gy total body irradiation +/− fludarabine, 30 mg/m²/day x 3 days, to condition elderly or ill patients (pts) with hematological malignancies for allogeneic hematopoietic cell transplantation (HCT). This approach relies almost exclusively on graft-versus-tumor (GVT) effects for control of malignancy. Here, we analyzed GVT effects in 322 pts with hematological malignancies given grafts from HLA-matched related (n=192) or unrelated (n=130) donors. Grades I, II, III and IV acute GVHD were seen in 26 (8.1%), 141 (43.8%),

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Liu-Ambrose, Teresa, Ryan S. Falck, Elizabeth Dao, et al. "Effect of Exercise Training or Complex Mental and Social Activities on Cognitive Function in Adults With Chronic Stroke." JAMA Network Open 5, no. 10 (2022): e2236510. http://dx.doi.org/10.1001/jamanetworkopen.2022.36510.

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ImportanceA stroke doubles one’s risk for dementia. How to promote cognitive function among persons with chronic stroke is unclear.ObjectiveTo evaluate the effect of exercise (EX) or cognitive and social enrichment activities (ENRICH) on cognitive function in adults with chronic stroke.Design, Setting, and ParticipantsThis was a 3-group parallel, single-blinded, single-site, proof-of-concept randomized clinical trial at a research center in Vancouver, British Columbia, Canada. Participants included community-dwelling adults with chronic stroke, aged 55 years and older, able to walk 6 meters, a

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Nabergoj, Mitja, Katya Mauff, Dietrich W. Beelen, et al. "Allogeneic Hematopoietic Cell Transplantation in Patients with Therapy-Related Myeloid Neoplasm after Breast Cancer: A Study of the Chronic Malignancies Working Party of the EBMT." Blood 136, Supplement 1 (2020): 3–4. http://dx.doi.org/10.1182/blood-2020-137773.

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Introduction: Therapy-related myeloid neoplasms (t-MNs) account for about 10 to 20% of all cases of AML and MDS. Allogenic hematopoietic cell transplantation (allo-HCT) is considered as the only curative treatment in this high-risk setting. Given the rise of long-term cancer survivors, an increasing number of patients are expected to become transplant candidates. Physicians are concerned about the frailty and the risk of recurrence of primary cancer. In this retrospective registry-based study, we focused on patients with t-MN secondary to breast cancer radio- and/or chemotherapy, and collected

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Boyer, Patricia M., Gabriela E. Compagnucci, María I. Olivera, et al. "Bone status in an animal model of chronic sub-optimal nutrition: a morphometric, densitometric and mechanical study." British Journal of Nutrition 93, no. 5 (2005): 663–69. http://dx.doi.org/10.1079/bjn20041331.

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In children, inappropriate eating habits can induce a disease known as nutritional dwarfing (ND). Due to the link between nutritional condition and bone growth, the effects induced by a 20 % reduction of food intake on bone competence were assessed in an animal model of ND. Bone status during catch-up growth was also analysed. Male Wistar rats were divided into control (C) and ND groups. C rats were fed ad libitum. ND received 80 % of the diet consumed by C for 4 weeks (T4); thereafter, they were fed ad libitum for 8 weeks. Results, expressed as mean (sem) for ND v. C, were as follows. At T4,

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Horneff, G., A. Zimmer, K. Minden, et al. "SAT0502 LONG-TERM OBSERVATIONAL SAFETY SURVEILLANCE OF GOLIMUMAB TREATMENT FOR POLYARTICULAR JUVENILE IDIOPATHIC ARTHIRTIS—AN INTERIM ANALYSIS." Annals of the Rheumatic Diseases 79, Suppl 1 (2020): 1207.1–1207. http://dx.doi.org/10.1136/annrheumdis-2020-eular.3589.

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Background:Golimumab (GOL) is approved for treatment of polyarticular juvenile idiopathic arthritis (pJIA) in patients 2 years and older. Data on long-term safety in this indication are limited.Objectives:Prospective monitoring of long-term safety and effectiveness of GOL in routine care using the German BIKER registry.Methods:In this non-interventional study baseline and safety parameters were compared between patients initiating GOL and contemporary matched control cohorts starting either an alternative TNF inhibitor (TNFi) or methotrexate (MTX) without exposure to a biologic. Efficacy outco

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Getgood, Alan M. J., Dianne M. Bryant, Robert Litchfield, et al. "Lateral Extra-articular Tenodesis Reduces Failure of Hamstring Tendon Autograft Anterior Cruciate Ligament Reconstruction: 2-Year Outcomes From the STABILITY Study Randomized Clinical Trial." American Journal of Sports Medicine 48, no. 2 (2020): 285–97. http://dx.doi.org/10.1177/0363546519896333.

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Background: Persistent anterolateral rotatory laxity after anterior cruciate ligament (ACL) reconstruction (ACLR) has been correlated with poor clinical outcomes and graft failure. Hypothesis: We hypothesized that a single-bundle, hamstring ACLR in combination with a lateral extra-articular tenodesis (LET) would reduce the risk of ACLR failure in young, active individuals. Study Design: Randomized controlled trial; Level of evidence, 1. Methods: This is a multicenter, prospective, randomized clinical trial comparing a single-bundle, hamstring tendon ACLR with or without LET performed using a s

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Diaz, Maria, Carlos Eduardo Silva Correia, Andrew Lin, Alexandra Miller, and Elena Pentsova. "PATH-04. LEPTOMENINGEAL DISEASE IN PATIENTS WITH HISTONE-MUTANT GLIOMAS." Neuro-Oncology 23, Supplement_6 (2021): vi115. http://dx.doi.org/10.1093/neuonc/noab196.457.

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Abstract INTRODUCTION The 2016 WHO classification describes a subtype of midline gliomas harboring histone 3 (H3) K27M mutations, and the upcoming 2021 edition may include a new subtype of hemispheric diffuse gliomas with H3 G34R/V mutations. Since we began to perform molecular profiling at Memorial Sloan Kettering Cancer Center (MSKCC) we have observed an increased prevalence of leptomeningeal disease (LMD) in this population. However, the incidence and clinical behavior of LMD has not been well defined. METHODS This is a retrospective study of patients with H3-mutant gliomas at MSKCC diagnos

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Frick, Mareike, Christopher Maximilian Arends, Joel Galan-Sousa, et al. "Clonal Hematopoiesis: Cell of Origin, Lineage Repartition and Dynamic Evolution during Chemotherapy." Blood 130, Suppl_1 (2017): 632. http://dx.doi.org/10.1182/blood.v130.suppl_1.632.632.

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Abstract Background: Clonal hematopoiesis of indeterminate potential (CHIP) is defined by the presence of hematologic cancer associated mutations in the peripheral blood (PB) of at least 10% of elderly people without history of hematologic disorders (Genovese et al ., NEJM, 2014; Jaiswal et al ., NEJM, 2014). At present, caution is needed when predicting clinical consequences from CHIP in healthy people. An essential step towards a better understanding of CHIP requires identification of the cell of origin, clonal expansion patterns within the hematopoietic differentiation tree, and its dynamic

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