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Journal articles on the topic '340.12: 314/316 (043.2)'

Author: Grafiati

Published: 30 May 2022

Last updated: 31 July 2025

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1

Wondafrash, Mekitie, Lieven Huybregts, Carl Lachat, Kimberley P. Bouckaert, and Patrick Kolsteren. "Dietary diversity predicts dietary quality regardless of season in 6–12-month-old infants in south-west Ethiopia." Public Health Nutrition 19, no. 14 (2016): 2485–94. http://dx.doi.org/10.1017/s1368980016000525.

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AbstractObjectiveSimple, cost-effective and convenient instruments like food group-based scores are proposed to assess micronutrient adequacy of children in developing countries. We assessed the predictive ability and seasonal stability of a dietary diversity score (DDS) to indicate dietary quality of infants.DesignA 24 h dietary recall assessment was carried out on a sample of 320 and 312 breast-fed infants aged 6–12 months during harvest (HS) and pre-harvest (PHS) seasons, respectively, in Ethiopia. DDS was calculated based on seven food groups, while mean micronutrient density adequacy (MMD

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Rashid, Taslima, Nirmitha Jayaratne, Marjan Taher, Tristan Barber, Nneka Nwokolo, and Michael Rayment. "P028 Characterising neisseria gonorrhoeae (NG) infections and treatment in a large, urban cohort." Sexually Transmitted Infections 93, Suppl 1 (2017): A26.3—A27. http://dx.doi.org/10.1136/sextrans-2017-053232.74.

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IntroductionBetter detection and more frequent testing may explain increases in NG. We wished to characterise patients attending our clinics with NG, and audit management against BASHH standards.Methods300 sequential NG patients attending in 2016 were reviewed. Data collected: demographics, NAAT/culture positivity (per site), antimicrobial treatment and resistance, and test of cure (TOC).ResultsMean age was 34 (17–65); 92% male; 75% white; 86% MSM. 415 site specific infections captured. Site distribution by NAAT, culture concordance/sensitivities, and TOC are presented below:Abstract P028 Tabl

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Aguiar, Daniel Moura de, Guacyara Tenório Cavalcante, Silvio Arruda Vasconcellos, et al. "Ocorrência de anticorpos anti-Brucella abortus e anti-Brucella canis em cães rurais e urbanos do Município de Monte Negro, Rondônia, Brasil." Ciência Rural 35, no. 5 (2005): 1216–19. http://dx.doi.org/10.1590/s0103-84782005000500039.

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Foram avaliados 304 cães de ambiente rural e urbano do município de Monte Negro, Rondônia, através do Antígeno Acidificado Tamponado (AAT), Soroaglutinação Lenta em Tubos (SAL) e 2-Mercaptoetanol (2-ME) para a pesquisa de anticorpos anti-Brucella abortus e da Imunodifusão em gel de ágar (IDGA) e Imunodifusão em gel de ágar com soro tratado com 2-Mercaptoetanol (IDGA-ME) para Brucella canis. Foram consideradas positivas as amostras reagentes nas provas confirmatórias do 2-ME e IDGA-ME. Verificaram-se 56 (18,4%) animais reagentes ao AAT e 12 (4,0%) reagentes a SAL. Apenas um cão (0,3%) foi consi

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Kivitz, A., A. F. Wells, J. Ignacio Vargas, et al. "POS0685 LONG-TERM SAFETY AND EFFICACY OF UPADACITINIB IN PATIENTS WITH RHEUMATOID ARTHRITIS: FINAL RESULTS FROM THE BALANCE-EXTEND OPEN-LABEL EXTENSION STUDY." Annals of the Rheumatic Diseases 81, Suppl 1 (2022): 620–21. http://dx.doi.org/10.1136/annrheumdis-2022-eular.1819.

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BackgroundUpadacitinib (UPA) was previously evaluated in two Phase 2, randomized, controlled trials (RCTs) in patients (pts) with rheumatoid arthritis (RA) and inadequate response to tumor necrosis factor inhibitors (BALANCE-1) or methotrexate (BALANCE-2).ObjectivesTo assess the final safety and efficacy of UPA in BALANCE-EXTEND, a 312-week open-label extension (OLE) enrolling pts who completed either BALANCE-1 or BALANCE-2.MethodsAll pts initially received UPA 6 mg twice daily (BID). Increase to 12 mg BID was required for pts with <20% improvement in swollen or tender joint counts (S/TJC)

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Oberti, R., F. Cámaraite, F. C. Hawthorne, and N. A. Ball. "Fluoro-aluminoleakeite, NaNa2(Mg2Al2Li)Si8O22F2, a new mineral of the amphibole group from Norra Kärr, Sweden: description and crystal structure." Mineralogical Magazine 73, no. 5 (2009): 817–24. http://dx.doi.org/10.1180/minmag.2009.073.5.817.

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AbstractFluoro-aluminoleakeite, ideally , is a new mineral of the amphibole group from Norra Kärr, Sweden (IMA-CNMMNC 2009-012). It occurs in a proterozoic alkaline intrusion that mainly comprises a fine-grained schistose agpaitic nepheline-syenite (grennaite). Fluoro- aluminoleakeite occurs as isolated prismatic crystals 0.10–2 mm long in a syenitic matrix. Crystals are light greenish-blue with a greenish-blue streak. It is brittle, has a Mohs hardness of 6 and a splintery fracture; it is non-fluorescent with perfect {110} cleavage, no observable parting, and has a calculated density of 3.14

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Grundy, H. F., R. Hardy, and M. H. Davies. "Effect of level of barley supplementation on the performance of continental × Holstein Friesian bulls given grass silage." Animal Science 58, no. 1 (1994): 35–40. http://dx.doi.org/10.1017/s0003356100007054.

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AbstractForty Charolais and 40 Limousin × Holstein Friesian bulls, 8 months old and weighing 315 kg live weight at the start of the experiment, were given grass silage to appetite throughout.From 315 to 425 kg live weight they received: no supplement (S0), 1 kg (S1), 2 kg (S2) or 4 kg (S4) of a rolled barley supplement per head per day. After a mean treatment live weight of 425 kg had been achieved for each breed, the daily supplement of all treatments was changed to 3 kg of rolled barley per head per day until individual animals were adjudged to have attained a European Community (EC) externa

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Chubarova, N. Y., A. A. Poliukhov, and I. D. Gorlova. "Long-term variability of aerosol optical thickness in Eastern Europe over 2001–2014 according to the measurements at the Moscow MSU MO AERONET site with additional cloud and NO<sub>2</sub> correction." Atmospheric Measurement Techniques 9, no. 2 (2016): 313–34. http://dx.doi.org/10.5194/amt-9-313-2016.

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Abstract. The atmospheric aerosol properties were obtained within the framework of the AERONET program at the Moscow State University Meteorological Observatory (Moscow MSU MO) over the 2001–2014 period. The quality data control has revealed the necessity of additional cloud screening and NO2 correction. The application of additional cloud screening according to hourly visual cloud observations provides a decrease in monthly average aerosol optical thickness (AOT) at 500 nm of up to 0.03 compared with the standard data set. We also show that the additional NO2 correction of the AERONET version

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de Moraes, Jermana L., Gabriela M. M. Paixão, Paulo R. Gomes, Eduardo M. A. M. Mendes, Antônio Luiz P. Ribeiro, and Alessandro Beda. "A novel algorithm to assess the quality of 12-lead ECG recordings: validation in a real telecardiology application." Physiological Measurement 44, no. 3 (2023): 035006. http://dx.doi.org/10.1088/1361-6579/acbc09.

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Abstract Objective. Automatic detection of Electrocardiograms (ECG) quality is fundamental to minimize costs and risks related to delayed diagnosis due to low ECG quality. Most algorithms to assess ECG quality include non-intuitive parameters. Also, they were developed using data non-representative of a real-world scenario, in terms of pathological ECGs and overrepresentation of low-quality ECG. Therefore, we introduce an algorithm to assess 12-lead ECG quality, Noise Automatic Classification Algorithm (NACA) developed in Telehealth Network of Minas Gerais (TNMG). Approach. NACA estimates a si

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Brundin, T., and J. Wahren. "Renal oxygen consumption, thermogenesis, and amino acid utilization during i.v. infusion of amino acids in man." American Journal of Physiology-Endocrinology and Metabolism 267, no. 5 (1994): E648—E655. http://dx.doi.org/10.1152/ajpendo.1994.267.5.e648.

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The renal contribution to the amino acid-induced whole body thermogenesis was examined. Using indirect calorimetry and catheter techniques, pulmonary and renal oxygen uptake and blood flow, blood temperatures, and net renal exchange of amino acids, glucose and lactate were measured in eight healthy men before and during 3 h of intravenous infusion of 720 kJ of an amino acid solution. During the infusion, the pulmonary oxygen uptake increased from 252 +/- 12 to 310 +/- 8 ml/min, cardiac output increased from 5.9 +/- 0.3 to 6.8 +/- 0.3 l/min, and the arterial blood temperature increased from 36.

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Grier, Abby, Albert Jang, Jeffrey Y. Zhong, et al. "Access to immune checkpoint inhibitors (ICI) in patients randomized to the control arm of ICI phase 3 trials in urothelial and renal cell cancers." Journal of Clinical Oncology 43, no. 5_suppl (2025): 448. https://doi.org/10.1200/jco.2025.43.5_suppl.448.

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448 Background: We investigated access to ICIs in patients (pts) randomized to the control arm across positive phase 3 trials for renal cell carcinoma (RCC) and urothelial carcinoma (UC) with an ICI-based regimen. Methods: A search of clinicaltrials.gov was performed in October 2024 including, “renal cell carcinoma” OR “urothelial cancer”, “immune”, and “phase 3”, producing 64 results. These were limited to trials with an investigational arm containing ICI therapy and without an ICI in the control arm, no cross over in initial trial design, and demonstrated overall survival benefit in the adju

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Popov, Ivan A., Alla I. Shikhlyarova, Elena M. Frantsiyants, et al. "Alternative ways to improving the quality of life in combination treatment for high-grade glioma." Journal of Clinical Oncology 39, no. 15_suppl (2021): e14031-e14031. http://dx.doi.org/10.1200/jco.2021.39.15_suppl.e14031.

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e14031 Background: The steady increase in the rates of high-grade gliomas (HGG) and poor results of antitumor therapy actualizes the problems of improving surgical and chemoradiation treatment, as well as accompanying therapy technologies for managing secondary disorders of neurological, cognitive, and adaptive status of neurooncological patients. Transcranial magnetotherapy (TMT) helps managing disorders of brain activity at the level of systemic and local regulation, including the mechanisms of formation of general anti-stress reactions of the body, as the basis for improving the quality of

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Bianchi, Paola, Elisa Fermo, Fulvio Mozzi, Maurizio Marconi, and Alberto Zanella. "Presence of JAK2 V617F Mutation in Peripheral Blood of Blood Donors with Upper-Limit Hematocrit and Platelet Values." Blood 110, no. 11 (2007): 2533. http://dx.doi.org/10.1182/blood.v110.11.2533.2533.

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Abstract The somatic mutation V617F of JAK2 gene has been identified as a pathogenic factor in typical chronic myeloproliferative diseases (MPDs), in particular polycythemia vera, essential thrombocythemia, and myelofibrosis with myeloid metaplasia. Recently, two studies showed the presence of this mutation also in 37/3935 subjects with non haematological diseases (Xu et al, 2006) and 5/52 healthy donors (Sidon et al, 2006), suggesting that V617F mutation may occur in the absence of MPD phenotype and that probably is not sufficient per se to induce MPDs. The aim of this study was to search for

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Minderico, Cláudia S., Analiza M. Silva, Kathleen Keller, et al. "Usefulness of different techniques for measuring body composition changes during weight loss in overweight and obese women." British Journal of Nutrition 99, no. 2 (2008): 432–41. http://dx.doi.org/10.1017/s0007114507815789.

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The objective was to compare measures from dual-energy X-ray absorptiometry (DXA), bioelectrical impedance analysis (BIA) and anthropometry with a reference four-compartment model to estimate fat mass (FM) and fat-free mass (FFM) changes in overweight and obese women after a weight-loss programme. Forty-eight women (age 39.8 ± 5.8 years; weight 79·2 ± 11·8 kg; BMI 30·7 ± 3·6 kg/m2) were studied in an out-patient weight-loss programme, before and after the 16-month intervention. Women attended weekly meetings for the first 4 months, followed by monthly meetings from 4 to 12 months. Body composi

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Fusar-Poli, Paolo, Andrea De Micheli, Rashmi Patel, et al. "Real-World Clinical Outcomes Two Years After Transition to Psychosis in Individuals at Clinical High Risk: Electronic Health Record Cohort Study." Schizophrenia Bulletin 46, no. 5 (2020): 1114–25. http://dx.doi.org/10.1093/schbul/sbaa040.

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Abstract The objective of this study is to describe the 2-year real-world clinical outcomes after transition to psychosis in patients at clinical high-risk. The study used the clinical electronic health record cohort study including all patients receiving a first index primary diagnosis of nonorganic International Classification of Diseases (ICD)-10 psychotic disorder within the early psychosis pathway in the South London and Maudsley (SLaM) National Health Service (NHS) Trust from 2001 to 2017. Outcomes encompassed: cumulative probability (at 3, 6, 12, and 24 months) of receiving a first (1)

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Gogate, Anagha, Amanda Crosbie, Trong Kim Le, Ying Zhang, Rolee Das, and Catherine Davis. "Abstract P3-12-15: Clinical characteristics, treatment patterns, and survival outcomes in women with early triple-negative (TN) or hormone receptor-positive/human epidermal growth factor receptor-2 negative (HR+/HER2−) breast cancer (BC) in the real-world (RW) setting." Cancer Research 82, no. 4_Supplement (2022): P3–12–15—P3–12–15. http://dx.doi.org/10.1158/1538-7445.sabcs21-p3-12-15.

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Abstract Background: BC remains the most commonly diagnosed cancer for women. TNBC is an aggressive form with a poorer prognosis compared with other subtypes. Neoadjuvant therapy (NAT) is the standard-of-care approach to shrink tumors in the breast and axilla and to improve patient outcomes. Few RW studies exist of US patients with early BC (eBC); this study aimed to describe clinical parameters by receipt of systemic therapy and to assess overall survival (OS) and progression-free survival (PFS) after NAT and adjuvant therapy (AT) in women with early HR+/HER2− or TNBC using RW evidence in the

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Koroljova‐Skorobogat'ko, Olga V., Elena V. Stepanova, Valeria P. Gavrilova, et al. "Purification and characterization of the constitutive form of laccase from the basidiomycete Coriolus hirsutus and effect of inducers on laccase synthesis." Biotechnology and Applied Biochemistry 28, no. 1 (1998): 47–54. http://dx.doi.org/10.1111/j.1470-8744.1998.tb00511.x.

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An isolate of Coriolus hirsutus constitutively expresses substantial amounts of extracellular laccase on a defined growth medium. The most efficient inducer of extracellular laccase synthesis was syringaldazine, which increased the enzyme yield by 1000% at a concentration of 0·11 μM. The constitutive form of the enzyme was purified 312‐fold. Laccase from C. hirsutus, with an estimated molecular mass of 55 kDa and pI of 4·0, is a monomeric glycoprotein containing 12% carbohydrate consisting of mannose and N‐acetylglucosamine. The laccase was found to contain 3·9–4·1 copper atoms per molecule. T

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Vihma, T., O. P. Mattila, R. Pirazzini, and M. M. Johansson. "Spatial and temporal variability in summer snow pack in Dronning Maud Land, Antarctica." Cryosphere 5, no. 1 (2011): 187–201. http://dx.doi.org/10.5194/tc-5-187-2011.

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Abstract. To quantify the spatial and temporal variability in the snow pack, field measurements were carried out during four summers in Dronning Maud Land, Antarctica. Data from a 310-km-long transect revealed the largest horizontal gradients in snow density, temperature, and hardness in the escarpment region. On the local scale, day-to-day temporal variability dominated the standard deviation of snow temperature, while the diurnal cycle was of second significance, and horizontal variability on the scale of 0.4 to 10 m was least important. In the uppermost 0.2 m, the snow temperature was corre

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Li, Bing, Jinqin Liu, Shiqiang Qu, et al. "Colony-Forming Unit Cell (CFU-C) Assays in Myelodysplastic Syndrome." Blood 126, no. 23 (2015): 2874. http://dx.doi.org/10.1182/blood.v126.23.2874.2874.

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Abstract Introduction: The myelodysplastic syndromes (MDS) are a group of clonal diseases derived from hematopoietic stem cells (HSC). Colony-forming unit cell (CFU-C) assay is an effective method to study the number and the function of HSC in vitro. In this study, we focus on the characteristics and the prognostic value of CFU-C in patients with MDS. Patients and Method: CFU-C assays were performed according to the protocol of MethoCultTM H4435 Enriched (STEMCELL Technologies). A colony was defined as an aggregate of >40 cells. Clusters consisted of 4 to 40 cells. 560 consecutive newly-dia

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Alten, R., G. R. Burmester, M. Matucci Cerinic, et al. "POS0666 A MULTINATIONAL, PROSPECTIVE, OBSERVATIONAL STUDY IN PATIENTS WITH RHEUMATOID ARTHRITIS RECEIVING BARICITINIB, TARGETED SYNTHETIC OR BIOLOGIC DISEASE-MODIFYING THERAPIES: 12 MONTH TIME TO DISCONTINUATION, EFFECTIVENESS AND PATIENT REPORTED OUTCOME DATA FROM THE EUROPEAN COHORT." Annals of the Rheumatic Diseases 81, Suppl 1 (2022): 606–7. http://dx.doi.org/10.1136/annrheumdis-2022-eular.265.

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BackgroundBaricitinib (BARI), an oral selective JAK 1/2 inhibitor, is approved for treating adults with moderate to severe active rheumatoid arthritis (RA). RA-BE-REAL is a 3-year, multinational, prospective, observational study of adult patients with RA evaluating time to discontinuation of initial RA treatment for all causes (excluding sustained clinical response) over 24 months (M).ObjectivesThis analysis reports time to discontinuation in the European (France, Germany, Italy, Spain, UK) subgroup, treated with either BARI, biologic (b) disease-modifying anti-rheumatic drugs (DMARDs) or any

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Chuprov, A. D., S. M. Kim, N. V. Korshunova, A. V. Fomenko, Y. S. Kuvaitseva, and I. S. Ryvkin. "Complex Therapy Response in Treatment of Partial Optic Atrophy of Various Origins." Medicina 8, no. 2 (2020): 1–9. http://dx.doi.org/10.29234/2308-9113-2020-8-2-1-9.

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Regional drugs injection is а promising method of partial optic atrophy treatment. The therapy involves the introduction of drugs into the microcirculation region on the side of the affected organ, in the area corresponding to the topographic projection of the lymph node. Purpose: To evaluate the effectiveness of treatment of partial optic atrophy of various origins using regional combination therapy. Material and Methods: Complex therapy was applied in hospital environment of The S. Fyodorov Eye Microsurgery Federal State Institution in treatment of 38 patients (38 eyes) with partial optic at

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Pieczka, Adam, Frank C. Hawthorne, Neil Ball, et al. "Graftonite-(Mn), ideallyM1MnM2,M3Fe2(PO4)2, and graftonite-(Ca), ideallyM1CaM2,M3Fe2(PO4)2, two new minerals of the graftonite group from Poland." Mineralogical Magazine 82, no. 6 (2018): 1307–22. http://dx.doi.org/10.1180/minmag.2017.081.109.

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AbstractTwo new minerals of the graftonite group, graftonite-(Mn), ideallyM(1)MnM(2),M(3)Fe2(PO4)2, and graftonite-(Ca), ideallyM(1)CaM(2),M(3)Fe2(PO4)2, were discovered in phosphate nodules of two beryl–columbite–phosphate pegmatites at Lutomia and Michałkowa, respectively, in the Góry Sowie Block, Lower Silesia, southwest Poland. Graftonite-(Mn) is pinkish brown, whereas graftonite-(Ca) shows more brownish colouration. Both minerals have a vitreous lustre, a good cleavage observed along (010) and irregular fracture; both are transparent and neither of them is fluorescent. They are brittle an

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He, Xin, Kyriakie Sarafoglou, Patricia Y. Fechner, et al. "Changes in Adrenal and Gonadal Androgens After 14-Day Treatment With CRF1 Receptor Antagonist, Crinecerfont (NBI-74788), in Men With Classic 21-Hydroxylase Deficiency." Journal of the Endocrine Society 5, Supplement_1 (2021): A78. http://dx.doi.org/10.1210/jendso/bvab048.157.

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Abstract Background: Congenital adrenal hyperplasia due to classic 21-hydroxylase deficiency (21OHD) causes cortisol insufficiency and androgen excess. A phase 2 trial of crinecerfont, a CRF1 receptor antagonist, in 18 adults with 21OHD showed prominent decreases in ACTH, 17-hydroxyprogesterone, and androstenedione (A4), and in women, testosterone (T), after 14 days of treatment. In men with 21OHD, T derives from both adrenals and testes; in poor disease control, A4/T ratio is elevated due to disproportionately increased adrenal A4 production and decreased testicular T production. We sought to

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Gordon, M., R. M. Staebler, J. Liggio, A. Vlasenko, S. M. Li, and K. Hayden. "Aerosol flux measurements above a mixed forest at Borden, Ontario." Atmospheric Chemistry and Physics 11, no. 14 (2011): 6773–86. http://dx.doi.org/10.5194/acp-11-6773-2011.

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Abstract. Aerosol fluxes were measured above a mixed forest by Eddy Covariance (EC) with a Fast Mobility Particle Sizer (FMPS) at the Borden Forest Research Station in Ontario, Canada between 13 July and 12 August 2009. Chemically speciated flux measurements were made at a height of 29 m at the same location between 19 July and 2 August, 2006 using a Quadrupole Aerosol Mass Spectrometer (Q-AMS). The Q-AMS measured an average sulphate deposition velocity of 0.3 mm s−1 and an average nitrate deposition velocity of 4.8 mm s−1. The FMPS, mounted at a height of 33 m (approximately 10 m above the ca

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Jaisupa, *Nattapon, Michael Ashton, and Sofia Birgersson. "DEVELOPMENT OF A PHYSIOLOGICALLY-BASED PHARMACOKINETIC (PBPK) MODEL TO PREDICT PLASMA AND BRAIN EXPOSURE FOLLOWING ADMINISTRATION OF VALPROIC ACID AND CLOBAZAM IN COMBINATION TREATMENT REGIMEN FOR DRAVET SYNDROME IN CHILDREN." International Journal of Neuropsychopharmacology 28, Supplement_1 (2025): i157—i158. https://doi.org/10.1093/ijnp/pyae059.272.

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Abstract Background Combination of valproic acid and clobazam is considered as a first-line option for Dravet syndrome (Wirrell and Nabbout, 2019). Therapeutic trough plasma concentration of valproic acid has been reported in the literature to be 50-100 mg/mL (Damegunta, 2014), and for clobazam between 30-300 ng/mL (de Leon, Spina and Diaz, 2013). A PBPK model to predict concentration-time data of valproic acid and clobazam in combination has not been established yet. Having such a model could be clinically useful for predicting the exposures of these drugs and forecasting clinical outcome. Ai

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Jiménez Labaig, Pablo, Failah Mohamed Lamin, Nur Jihan Irwan Tan, et al. "Low-dose anti-PD-(L)1 inhibitor strategies: A systematic review." Journal of Clinical Oncology 43, no. 16_suppl (2025): 1526. https://doi.org/10.1200/jco.2025.43.16_suppl.1526.

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1526 Background: Immune checkpoint inhibitors (ICIs) targeting the PD-(L)1 pathway have revolutionized cancer therapy, but their high costs significantly limit accessibility, particularly in low- and middle-income countries (LMICs). Low-dose regimens may offer a viable solution to this challenge. This systematic review analysed study designs, dosing strategies, clinical outcomes, and potential cost savings of low-dose ICIs. Methods: A PRISMA/EQUATOR compliant systematic search of WebOfScience, Cochrane Central Register of Clinical Trials, ASCO and ESMO conference databases was conducted until

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Hellmann, Matthew D., Scott Joseph Antonia, Ani Sarkis Balmanoukian, et al. "Updated overall survival and safety profile of durvalumab monotherapy in advanced NSCLC." Journal of Clinical Oncology 36, no. 5_suppl (2018): 169. http://dx.doi.org/10.1200/jco.2018.36.5_suppl.169.

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169 Background: Single-agent durvalumab is being evaluated in patients with advanced squamous and non-squamous NSCLC in an ongoing Phase 1/2 study (NCT01693562). Here we present updated survival and safety data in NSCLC patients. Methods: Treatment-naïve (1L) and previously treated (2L or 3L+) stage IIIB/IV NSCLC patients received durvalumab 10 mg/kg Q2W for up to 12 months. Patients were stratified by tumor PD-L1 expression (Ventana PD-L1 [SP263] Assay [PD-L1 high: ≥25% of tumor cells with membrane staining]), treatment line, and histology. Results: As of 05 September 2017, 304 NSCLC patients

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Martynova, A., T. Popkova, A. Aleksankin, and E. Gerasimova. "AB0068 B- AND T- LYMPHOCYTE SUBSETS IN PATIENTS WITH EARLY AND PROGRESSED RHEUMATOID ARTHRITIS." Annals of the Rheumatic Diseases 80, Suppl 1 (2021): 1064.2–1065. http://dx.doi.org/10.1136/annrheumdis-2021-eular.3816.

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Background:Role of B- and T- lymphocytes is well established in pathogenesis of rheumatoid arthritis (RA). Self-containing activation of B-cells in ectopic germinative centers is followed by auto-activation of T-lymphocytes while T-cells themselves are antigen-presenting cells for B-lymphocytes [1-2]. As these processes continue with the duration of RA, different subsets of B- and T-cell might be prevalent at different stages of RA.Objectives:Evaluate differences in dynamics of B- and T- cell subsets in early and progressed RA.Methods:53 patients with diagnosed RA(ACR/EULAR 2010 criteria) were

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Zhong, Runbo, Min Yan, Qiming Wang, et al. "Phase 1 trial of SHR-A2102, a nectin-4–directed antibody drug conjugate (ADC), in advanced solid tumors." Journal of Clinical Oncology 43, no. 16_suppl (2025): 107. https://doi.org/10.1200/jco.2025.43.16_suppl.107.

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107 Background: Nectin-4 is a cell adhesion molecule that is highly expressed in a wide variety of cancers and is associated with poor prognosis. SHR-A2102 is a novel ADC consisting of a fully humanized Nectin-4–directed monoclonal antibody, bound to topoisomerase I inhibitor payload via a cleavable linker. We conducted a multi-center, phase 1 trial to evaluate SHR-A2102 in advanced solid tumors. Methods: Patients (pts) with Nectin-4 positive, locally advanced unresectable or metastatic solid tumors were enrolled. The study included dose-escalation (D-ESC), dose-expansion (D-EXP) and efficacy-

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Lucas, C., S. Rodriguez, R. Jean, et al. "AB0034 EARLY IMMUNIZATION AGAINST TREATMENT IS ASSOCIATED TO POOR CLINICAL RESPONSE AT 6 MONTHS AND LOW NUMBER OF TRANSITIONAL B CELLS AT BASELINE IN RHEUMATOID ARTHRITIS PATIENTS TREATED BY ADALIMUMAB." Annals of the Rheumatic Diseases 79, Suppl 1 (2020): 1319.1–1320. http://dx.doi.org/10.1136/annrheumdis-2020-eular.3938.

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Background:Circulating anti-drug antibodies (ADAs) are detectable approximatively in 33% of adalimumab treated rheumatoid arthritis (RA) patients, often within the first 6 months of therapy1-2. Classically, circulating ADAs associate with their specific drugs to form immune complexes, increasing drug clearance, and by this mechanism reducing therapeutic effect3. B cell involvement leading to ADAs production is not yet well established.Objectives:To study early ADAs formation according to clinical response to an adalimumab therapy in RA patients and the relationship between ADAs and circulating

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Rosti, Gianantonio, Fausto Castagnetti, Ilaria Iacobucci, et al. "Imatinib 400 mg in Early Chronic Phase CML: Results of a Multicentric, Prospective Non Academical Observational Study (by the GIMEMA CML Working Party)." Blood 108, no. 11 (2006): 4777. http://dx.doi.org/10.1182/blood.v108.11.4777.4777.

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Abstract Imatinib 400 mg (SD) is the established first line treatment of chronic myeloid leukemia (CML) in chronic phase. The efficacy of imatinib in early chronic phase has been demonstrated by phase 2 and 3 controlled trials like the IRIS study (O’ Brien et al NEJM 348:11, 2004). Large multicentric studies aimed to evaluate the impact of imatinib 400 mg outside strictly monitored frameworks are not yet available. The GIMEMA (Gruppo Italiano Malattie Ematologiche dell’Adulto) CML Working Party opened in January, 2004, an observational study (serial n. CML/023) to investigate the efficacy of i

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Infantino, A., N. Pucci, G. Conca, and A. Santori. "First Report of Fusarium langsethiae on Durum Wheat Kernels in Italy." Plant Disease 91, no. 10 (2007): 1362. http://dx.doi.org/10.1094/pdis-91-10-1362a.

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Durum wheat (Triticum durum Desf.) is one of the most widely grown crops in Italy, extending to approximately 1.5 million ha. Seedborne fungi, affecting both germination and commercial quality of the product, represent a threat to wheat production. Several Fusarium species produce mycotoxins, secondary metabolites harmful to humans and animals. In 2006, monitoring the health status of durum wheat kernels from central (Pollenza, MC) and southern Italy (Foggia; Gravina di Puglia, BA; Enna) was conducted. Kernels at the 11.3 Feeke's scale growth stage were analyzed with the deep freezing blotter

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Borad, Mitesh J., Shantan G. Reddy, Nathan Bahary, et al. "Randomized Phase II Trial of Gemcitabine Plus TH-302 Versus Gemcitabine in Patients With Advanced Pancreatic Cancer." Journal of Clinical Oncology 33, no. 13 (2015): 1475–81. http://dx.doi.org/10.1200/jco.2014.55.7504.

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Purpose TH-302 is an investigational hypoxia-activated prodrug that releases the DNA alkylator bromo-isophosphoramide mustard in hypoxic settings. This phase II study (NCT01144455) evaluated gemcitabine plus TH-302 in patients with previously untreated, locally advanced or metastatic pancreatic cancer. Patients and Methods Patients were randomly assigned 1:1:1 to gemcitabine (1,000 mg/m2), gemcitabine plus TH-302 240 mg/m2 (G+T240), or gemcitabine plus TH-302 340 mg/m2 (G+T340). Randomized crossover after progression on gemcitabine was allowed. The primary end point was progression-free surviv

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Hammer, H. B., B. Michelsen, J. Sexton, T. Uhlig, and S. Aarrestad Provan. "THU0129 SLEEP DISTURBANCE AND LOW INFLAMMATION PREDICT A PATTERN OF CHRONIC FATIGUE IN ACTIVELY TREATED PATIENTS WITH ESTABLISHED RA." Annals of the Rheumatic Diseases 79, Suppl 1 (2020): 279.2–280. http://dx.doi.org/10.1136/annrheumdis-2020-eular.3532.

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Background:Fatigue is common among patients with rheumatoid arthritis (RA) and has major impact on the burden of disease. There is little knowledge regarding the factors predicting the longitudinal development of chronic fatigue.Objectives:To identify baseline predictors for the development of chronic fatigue in patients with RA who initiate biological DMARD (bDMARD) treatment, and to compare disease courses across categories of fatigue for 12 months follow-up.Methods:Different trajectories of fatigue were calculated from a cohort of 209 established RA patients initiating bDMARDs. Fatigue was

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Poddubnyy, D., L. S. Gensler, P. J. Mease, et al. "AB0938 SAFETY PROFILE OF BIMEKIZUMAB AT WEEK 16 IN PATIENTS WITH AXIAL SPONDYLOARTHRITIS AND PSORIATIC ARTHRITIS: RESULTS FROM FOUR PLACEBO-CONTROLLED PHASE 3 STUDIES." Annals of the Rheumatic Diseases 82, Suppl 1 (2023): 1686–87. http://dx.doi.org/10.1136/annrheumdis-2023-eular.2758.

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BackgroundBimekizumab (BKZ) is a monoclonal IgG1 antibody that selectively inhibits interleukin (IL)-17F in addition to IL-17A.ObjectivesTo report Week (Wk) 0–16 safety of BKZ and placebo (PBO) in 2 axial spondyloarthritis (axSpA) and 2 psoriatic arthritis (PsA) phase 3 studies.MethodsPatients (pts) in 2 safety pools received ≥1 dose of subcutaneous BKZ 160 mg or PBO every 4 wks during Wks 0–16 (double-blind phase) of BE MOBILE 1 + BE MOBILE 2 in axSpA (NCT03928704; 03928743); BE OPTIMAL + BE COMPLETE in PsA (NCT03895203; 03896581) (Figure 1)[1-4].ResultsWk 16 completion rates: 95.8% (PBO), 97

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Taylor, P. C., C. Charles-Schoeman, M. Alani, et al. "POS0660 CONCOMITANT USE OF STATINS IN FILGOTINIB-TREATED PATIENTS WITH RHEUMATOID ARTHRITIS." Annals of the Rheumatic Diseases 80, Suppl 1 (2021): 572–73. http://dx.doi.org/10.1136/annrheumdis-2021-eular.933.

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Background:The Janus kinase-1 preferential inhibitor filgotinib (FIL) improved rheumatoid arthritis (RA) signs and symptoms in phase (P)3 trials.1–3 RA elevates cardiovascular disease risk; statins are used to reduce risk.Objectives:To assess safety of statin and filgotinib coadministration across the clinical program.Methods:Patients (pts) meeting 2010 ACR/EULAR RA criteria in P2 DARWIN 1–2 (D1–2; NCT01888874, NCT01894516), P3 FINCH 1–3 (F1–3; NCT02889796, NCT02873936, NCT02886728), and long-term extensions DARWIN 3 and FINCH 4 (D3, F4; NCT02065700, NCT03025308) receiving FIL 100 mg (FIL100)

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Galuskin, Evgeny V., Biljana Krüger, Irina O. Galuskina, et al. "Levantite, KCa3(Al2Si3)O11(PO4), a new latiumite-group mineral from the pyrometamorphic rocks of the Hatrurim Basin, Negev Desert, Israel." Mineralogical Magazine 83, no. 5 (2019): 713–21. http://dx.doi.org/10.1180/mgm.2019.37.

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AbstractLevantite, with the end-member formula KCa3(Al2Si3)O11(PO4), is the phosphate analogue of latiumite, KCa3(Al3Si2)O11(SO4, CO3) found in gehlenite–wollastonite hornfels on Har Parsa, Negev Desert, Israel. Levantite forms later zones on long-prismatic crystals of latiumite. Rarer homogeneous colourless levantite crystals up to 0.2 mm long and with mean composition (K0.94Ba0.01Na0.01□0.04)Σ1.00(Ca2.96Mg0.03)Σ2.99{(Si2.69Al2.06Fe3+0.16P0.06)Σ4.97O11}[(PO4)0.65(SO4)0.35]Σ1.00 were noted. Minerals of the levantite–latiumite series are associated with gehlenite, wollastonite, clinopyroxene of

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Bushman, Jordan, Nazanene Esfandiari, Jayapalli Bapuraj, and David Shlensky. "RF25 | PMON76 Kissing carotid arteries: An unusual cause of male hypogonadotropic hypogonadism." Journal of the Endocrine Society 6, Supplement_1 (2022): A586. http://dx.doi.org/10.1210/jendso/bvac150.1214.

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Abstract Background Aneurysms of the internal carotid arteries are a rare cause of pituitary dysfunction1. While there are reports of primary amenorrhea in females due to ectatic internal carotid arteries2, hypogonadism in a male due to "kissing internal carotid arteries" causing compression of the pituitary gland has not previously been reported. Clinical Case A 27-year-old male with history of Crohn's disease, obesity, depression and sleep apnea on CPAP presented to endocrinology clinic for evaluation of low testosterone levels diagnosed 9 months prior to his initial visit. At the time of in

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Michelena, X., S. S. Zhao, S. Dubash, G. T. Jones, L. Dean, and H. Marzo-Ortega. "FRI0287 BIOLOGIC DRUG RESPONSE DOES NOT APPEAR RELATED TO RADIOGRAPHIC STATUS IN AXIAL SPONDYLOARTHRITIS: DATA FROM THE BSRBR-AS REGISTRY." Annals of the Rheumatic Diseases 79, Suppl 1 (2020): 732.2–732. http://dx.doi.org/10.1136/annrheumdis-2020-eular.3147.

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Background:The concept of axial spondyloarthritis (axSpA) incorporates the full range of inflammatory spinal disease. In the absence of specific immuno-genetic biomarkers, classification criteria differentiate two groups (non-radiographic [nr-axSpA] and radiographic axSpA [r-axSpA]) based on the presence of structural damage of the sacroiliac joints. Controversy remains as to whether nr-axSpA represents a milder form with biologic DMARD (bDMARD) treatment restrictions still in place in many countries.Table 1.Baseline characteristics of nr-axSpA and r-axSpA patients starting biologics.Variables

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Adami, G., D. Gatti, A. Giollo, et al. "OP0112 FACTORS ASSOCIATED WITH OSTEOPOROSIS CARE OF MEN: A REAL-LIFE STUDY ON A NATION-WIDE DATASET." Annals of the Rheumatic Diseases 80, Suppl 1 (2021): 62.1–62. http://dx.doi.org/10.1136/annrheumdis-2021-eular.257.

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Background:Male osteoporosis is associated with an important clinical and economic burden worldwide. Notwithstanding that, undertreatment of men with osteoporosis is common. Understanding the factors associated with less osteoporosis care utilization might help define future intervention to improve access of men to osteoporosis care.Objectives:The aim of the study was to describe the factors associated with osteoporosis care in men.Methods:We conducted a retrospective analysis of a nation-wide cohort (DeFRACalc79 database). DeFRACalc79 is a tool that estimates the fracture risk considering cli

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Porceddu, Sandro Virgilio, Michael Poulsen, Mathias Bressel, et al. "Post-operative concurrent chemo-radiotherapy versus post-operative radiotherapy in high-risk cutaneous squamous cell carcinoma of the head and neck: A randomized phase III trial (Trans Tasman Radiation Oncology Group 05.01 Trial; POST study)." Journal of Clinical Oncology 35, no. 15_suppl (2017): 6008. http://dx.doi.org/10.1200/jco.2017.35.15_suppl.6008.

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6008 Background: We report on the first multi-centre randomized phase III trial of post-operative radiotherapy (PORT) vs post-operative chemo-RT (CRT) in high-risk cutaneous squamous cell carcinoma of the head and neck (cSCCHN) (NCT00193895). Methods: The primary objective was to determine whether there was a freedom from loco-regional relapse (FLRR) difference between patients randomly assigned to 60-66Gy (6-6.5 weeks) with or without weekly carboplatin (AUC 2) following resection of gross disease. Patients were stratified to high-risk nodal (either extracapsular nodal extension, intra-paroti

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Winthrop, K., M. H. Buch, J. Curtis, et al. "POS0092 HERPES ZOSTER IN THE FILGOTINIB RHEUMATOID ARTHRITIS PROGRAM." Annals of the Rheumatic Diseases 80, Suppl 1 (2021): 255.1–256. http://dx.doi.org/10.1136/annrheumdis-2021-eular.1408.

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Background:The once daily, oral Janus kinase (JAK)-1 preferential inhibitor filgotinib (FIL) improved signs and symptoms of rheumatoid arthritis (RA) in phase (P)3 trials.1-3 Patients (pts) with RA have increased herpes zoster (HZ) reactivation risk vs the general population. JAK inhibition is associated with increased infection incidence, including HZ.4Objectives:To assess long-term safety of FIL across the global clinical program with respect to HZ.Methods:Pts meeting 2010 ACR/EULAR RA criteria in a pooled analysis of P2 DARWIN 1–2 (D1–2), P3 FINCH 1–3 (F1–3), and long-term extension studies

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Lisukov, Igor, Alexander Kulagin, Alexey Maschan, et al. "Effect of Eculizumab on Physician-Reported Symptoms in the Russian Cohort of the Paroxysmal Nocturnal Hemoglobinuria (PNH) International Registry." Blood 124, no. 21 (2014): 5163. http://dx.doi.org/10.1182/blood.v124.21.5163.5163.

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Abstract Background: Paroxysmal nocturnal hemoglobinuria is a rare clonal hematopoietic stem cell disease that can lead to life-threatening complications including thrombotic events (TE), chronic kidney disease (CKD) and pulmonary hypertension. In 2011 the International PNH Registry was implemented in the Russian PNH cohort to assess the natural history of PNH and the effects of treatment with eculizumab. Aims:We aim to evaluate the change from baseline to last follow-up in physician-reported symptoms, LDH and hemoglobin concentration in treated and untreated PNH patients. Design and methods:

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Magrey, M., M. G. H. Van de Sande, M. Breban, et al. "POS1107 BIMEKIZUMAB ACHIEVED SUSTAINED IMPROVEMENTS IN EFFICACY OUTCOMES IN PATIENTS WITH AXIAL SPONDYLOARTHRITIS, REGARDLESS OF PRIOR TNF INHIBITOR TREATMENT: WEEK 52 POOLED RESULTS FROM TWO PHASE 3 STUDIES." Annals of the Rheumatic Diseases 82, Suppl 1 (2023): 876–77. http://dx.doi.org/10.1136/annrheumdis-2023-eular.836.

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BackgroundIn patients (pts) with axial spondyloarthritis (axSpA), tumour necrosis factor inhibitors (TNFi) are the usual first line biologic treatment, yet many pts may experience loss of response over time, and some are intolerant to TNFis.[1]Typically, response to second line biologics is limited in TNFi-inadequate responders (IR).Bimekizumab (BKZ) is a monoclonal IgG1 antibody that selectively inhibits IL-17F in addition to IL-17A. In the phase 3 BE MOBILE 1 and 2 studies, BKZ treatment resulted in rapid and sustained improvements in efficacy outcomes through 52 weeks (wks) in pts with acti

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Van der Heijde, D., L. S. Gensler, A. Deodhar, et al. "OP0105 EFFICACY AND SAFETY OF BIMEKIZUMAB IN ANKYLOSING SPONDYLITIS: 48-WEEK PATIENT-REPORTED OUTCOMES FROM A PHASE 2B, RANDOMISED, DOUBLE-BLIND, PLACEBO-CONTROLLED, DOSE-RANGING STUDY." Annals of the Rheumatic Diseases 79, Suppl 1 (2020): 68–69. http://dx.doi.org/10.1136/annrheumdis-2020-eular.323.

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Background:Bimekizumab (BKZ), a monoclonal antibody that selectively neutralises interleukin (IL)-17A and IL-17F, is a potential therapeutic option in ankylosing spondylitis (AS).Objectives:To report 48-week (wk) patient-reported outcomes (PROs) in patients (pts) with AS treated with BKZ in a phase 2b dose-ranging study (BE-AGILE;NCT02963506).Methods:Pts with active AS (Bath AS Disease Activity Index [BASDAI] ≥4; spinal pain ≥4 [0–10]), fulfilling modified New York criteria (central reading), and inadequate response/intolerance to NSAIDs were randomised according to the study design (Figure 1)

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Altabás González, I., I. Rua-Figueroa, N. Jiménez, et al. "POS0759 DOES LLDAS DEFINITION MATCH THE RHEUMATOLOGIST OPINION? THE FIRST VISIT EVALUATION OF A LONGITUDINAL SPANISH MULTICENTER STUDY TO ASSESS REASONS OF DISAGREEMENT." Annals of the Rheumatic Diseases 81, Suppl 1 (2022): 665.3–666. http://dx.doi.org/10.1136/annrheumdis-2022-eular.3044.

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BackgroundTreat to Target strategies are necessary in Systemic Lupus Erythematosus (SLE). They are difficult to establish due to the heterogeneity of the disease. The current definitions of Lupus Low Disease Activity State (LLDAS) according to the Asia Pacific Lupus Collaboration (APLC) and remission according to Definition of Remission in SLE (DORIS) 2021 are difficult to achieve and maintain over time.ObjectivesTo evaluate the concordance between the LLDAS and the clinical status according to the rheumatologist opinion and reasons of disagreement. To explore modifications in LLDAS definition

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Pang, Yifan, Ananth V. Charya, Michael B. Keller, et al. "A New Diagnostic Classification Tool for Pulmonary Chronic Graft-Versus-Host-Disease: Adaptation of the International Society for Heart and Lung Transplantation Chronic Lung Allograft Dysfunction Consensus Criteria." Blood 138, Supplement 1 (2021): 3919. http://dx.doi.org/10.1182/blood-2021-145994.

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Abstract Background: Although bronchiolitis obliterans syndrome (BOS) is a well described manifestation of pulmonary involvement by chronic graft-versus-host disease (PcGvHD), additional pulmonary phenotypes of PcGvHD beyond BOS have not been well-characterized. PcGvHD and chronic lung allograft dysfunction (CLAD) in lung transplant recipients share similar pathophysiological mechanisms. We aim to use an adaptation of the International Society for Heart and Lung Transplantation (ISHLT) CLAD Consensus Criteria to describe PcGvHD phenotypes beyond BOS in order to improve the diagnosis and classi

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Judah, Gaby, Ara Darzi, Ivo Vlaev, et al. "Incentives in Diabetic Eye Assessment by Screening (IDEAS) trial: a three-armed randomised controlled trial of financial incentives." Health Services and Delivery Research 5, no. 15 (2017): 1–60. http://dx.doi.org/10.3310/hsdr05150.

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BackgroundThe UK national diabetic eye screening (DES) programme invites diabetic patients aged > 12 years annually. Simple and cost-effective methods are needed to increase screening uptake. This trial tests the impact on uptake of two financial incentive schemes, based on behavioural economic principles.ObjectivesTo test whether or not financial incentives encourage screening attendance. Secondarily to understand if the type of financial incentive scheme used affects screening uptake or attracts patients with a different sociodemographic status to regular attenders. If financial incentive

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Hatakeyama, Akihisa, Hajime Utsunomiya, Shoichi Nishikino, et al. "Predictors of Poor Clinical Outcome After Arthroscopic Labral Preservation, Capsular Plication, and Cam Osteoplasty in the Setting of Borderline Hip Dysplasia." American Journal of Sports Medicine 46, no. 1 (2017): 135–43. http://dx.doi.org/10.1177/0363546517730583.

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Background: Borderline developmental dysplasia of the hip (BDDH) is frequently diagnosed concurrently with cam impingement. While hip arthroscopy has advanced the treatment of hip joint pathology, including femoroacetabular impingement (FAI), arthroscopic treatment for FAI in the setting of BDDH remains a challenge amid a subset of patients. The risk factors of poor clinical results after hip arthroscopic labral preservation and FAI corrections in the setting of BDDH patients have not been well established. Hypothesis: Pre- and intraoperative findings can predict the poor clinical outcomes aft

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Gomes, Tiago Halyson de Oliveira, Beatriz Pellizzon, Giovanna Victória Moura Araújo, et al. "MAMOPLASTIA PÓS BARIÁTRICA." Revista ft 29, no. 144 (2025): 02–03. https://doi.org/10.69849/revistaft/fa10202503150102.

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INTRODUÇÃO: A mamoplastia pós bariátrica é um procedimento cirúrgico realizado para remodelar as mamas de pacientes que passaram por cirurgia bariátrica, visando corrigir a flacidez e o excesso de pele resultantes da perda significativa de peso. Esse procedimento é indicado para melhorar a estética e a autoestima dos pacientes, após a redução substancial de peso corporal. OBJETIVOS: O objetivo do presente trabalho foi realizar o levantamento acerca dos procedimentos cirúrgicos de mamoplastia pós bariátrica no Brasil, entre o período de 2013 a 2024. METODOLOGIA: O presente estudo trata-se de um

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Shangaris, Panicos, Stavros P. Loukogeorgakis, Sindhu Subramaniam, et al. "Correction of Hemoglobin Levels in a Heterozygous Humanized Mouse Model of Thalassemia after Fetal Gene Therapy." Blood 124, no. 21 (2014): 3495. http://dx.doi.org/10.1182/blood.v124.21.3495.3495.

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Abstract Background Beta thalassaemia is a genetic blood disease that causes life-threatening anemia. Hematopoietic stem cell (HSC) transplantation successfully cures the disease but in only 30% of patients. We hypothesized that in utero gene therapy (IUGT) to the fetal HSC compartment with the corrected beta globin gene might cure the disease before birth. Methods A humanized mouse model of thalassemia (Cooley's anemia; CA) was used in which heterozygous animals are affected by anemia, splenomegaly and extra-medullary hematopoiesis. At E13.5 a “GLOBE” vector (HIV-2 based lentiviral vector tha

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